                         SEQUENCE LISTING

<110>  The Univiersity of North Carolina at Chapel Hill
       Spyryx LLC
       Tarran, Robert
       Christensen, Dale J.
 
<120>  IMPROVED PEPTIDE INHIBITORS OF SODIUM CHANNELS

<130>  5470-721WO

<150>  US 62/061,461
<151>  2014-10-08

<160>  144   

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  1

Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu Pro Leu Asn Val Asn 
1               5                   10                  15      


Pro Ala 
        


<210>  2
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (18)..(19)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  AMIDATION

<400>  2

Xaa Xaa Leu Pro Val Pro Leu Asp Gln Thr Leu Pro Leu Asn Val Asn 
1               5                   10                  15      


Pro Xaa Xaa 
            


<210>  3
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  3

Xaa Xaa Leu Pro Val Pro Leu Asp Gln Thr Xaa Xaa 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  4

Xaa Xaa Xaa Pro Val Pro Leu Asp Gln Thr Xaa Xaa 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  5

Xaa Xaa Leu Pro Xaa Pro Leu Asp Gln Thr Xaa Xaa 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  6

Xaa Xaa Leu Pro Val Pro Xaa Asp Gln Thr Xaa Xaa 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  7

Xaa Xaa Leu Pro Val Pro Leu Asp Asn Thr Xaa Xaa 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  8

Xaa Xaa Leu Pro Val Pro Leu Glu Gln Thr Xaa Xaa 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  9

Xaa Xaa Leu Pro Val Pro Leu Asp Gln Ser Xaa Xaa 
1               5                   10          


<210>  10
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  10

Leu Pro Val Pro Leu Asp Gln Thr 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  11

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  12

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is DHP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  13

Leu Xaa Val Xaa Leu Asp Gln Thr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is 2PP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  14

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is 2PP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  15

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  16

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  17

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  18

Leu Xaa Val Xaa Leu Asp Gln Thr 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  19

Leu Pro Val Pro Leu Glu Gln Ser 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is MS

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  20

Leu Pro Val Pro Leu Glu Gln Xaa 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  21

Leu Pro Val Pro Val Asp Gln Thr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  22

Leu Pro Val Pro Val Glu Gln Ser 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  23

Leu Pro Val Pro Val Asp Gln Ser 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  24

Val Pro Val Pro Leu Asp Gln Thr 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  25

Leu Pro Leu Pro Leu Asp Gln Ser 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  26

Val Pro Leu Pro Leu Asp Gln Ser 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  27

Leu Pro Leu Pro Leu Asp Gln Thr 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  28

Val Xaa Leu Xaa Val Glu Gln Ser 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  29

Val Pro Leu Pro Val Glu Gln Ser 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  30

Leu Pro Leu Pro Leu Glu Gln Ser 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is mV

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  31

Leu Pro Xaa Pro Leu Asp Gln Ser 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  32

Leu Pro Xaa Pro Leu Asp Gln Thr 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  33

Leu Pro Xaa Pro Val Glu Gln Ser 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  34

Leu Pro Xaa Pro Val Glu Gln Ser 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  35

Leu Xaa Xaa Xaa Leu Glu Gln Ser 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is NYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  36

Leu Xaa Xaa Xaa Val Glu Gln Ser 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  37

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is DHP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  38

Leu Xaa Val Xaa Leu Asp Gln Thr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is 2PP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  39

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is 2PP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  40

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  41

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  42

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  43

Leu Xaa Val Xaa Leu Asp Gln Thr 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  44

Leu Pro Val Pro Leu Glu Gln Ser 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is MS

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  45

Leu Pro Val Pro Leu Glu Gln Xaa 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  46

Leu Pro Val Pro Val Asp Gln Thr 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  47

Leu Pro Val Pro Val Glu Gln Ser 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  48

Leu Pro Val Pro Val Asp Gln Ser 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  49

Val Pro Val Pro Leu Asp Gln Thr 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  50

Leu Pro Leu Pro Leu Asp Gln Ser 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  51

Val Pro Leu Pro Leu Asp Gln Ser 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  52

Leu Pro Leu Pro Leu Asp Gln Thr 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  53

Val Xaa Leu Xaa Val Glu Gln Ser 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  54

Val Pro Leu Pro Val Glu Gln Ser 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  55

Leu Pro Leu Pro Leu Glu Gln Ser 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is mV

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  56

Leu Pro Xaa Pro Leu Asp Gln Ser 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  57

Leu Pro Xaa Pro Leu Asp Gln Thr 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  58

Leu Pro Xaa Pro Val Glu Gln Ser 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  59

Leu Pro Xaa Pro Val Glu Gln Ser 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  60

Leu Xaa Xaa Xaa Leu Glu Gln Ser 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  61

Leu Xaa Xaa Xaa Val Glu Gln Ser 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  62

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  63

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is DHP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  64

Leu Xaa Val Xaa Leu Asp Gln Thr 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is 2PP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  65

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is 2PP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  66

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  67

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  68

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  69

Leu Xaa Val Xaa Leu Asp Gln Thr 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  70

Leu Pro Val Pro Leu Glu Gln Ser 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is MS

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  71

Leu Pro Val Pro Leu Glu Gln Xaa 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  72

Leu Pro Val Pro Val Asp Gln Thr 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  73

Leu Pro Val Pro Val Glu Gln Ser 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  74

Leu Pro Val Pro Val Asp Gln Ser 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  75

Val Pro Val Pro Leu Asp Gln Thr 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  76

Leu Pro Leu Pro Leu Asp Gln Ser 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  77

Val Pro Leu Pro Leu Asp Gln Ser 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  78

Leu Pro Leu Pro Leu Asp Gln Thr 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  79

Val Xaa Leu Xaa Val Glu Gln Ser 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  80

Val Pro Leu Pro Val Glu Gln Ser 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  81

Leu Pro Leu Pro Leu Glu Gln Ser 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is mV

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  82

Leu Pro Xaa Pro Leu Asp Gln Ser 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  83

Leu Pro Xaa Pro Leu Asp Gln Thr 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  84

Leu Pro Xaa Pro Val Glu Gln Ser 
1               5               


<210>  85
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  85

Leu Pro Xaa Pro Val Glu Gln Ser 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  86

Leu Xaa Xaa Xaa Leu Glu Gln Ser 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  87

Leu Xaa Xaa Xaa Val Glu Gln Ser 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  88

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is DHP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  89

Leu Xaa Val Xaa Leu Asp Gln Thr 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is 2PP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  90

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  91
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is 2PP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  91

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  92
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  92

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  93

Leu Pro Val Xaa Leu Asp Gln Thr 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  94

Leu Xaa Val Xaa Leu Asp Gln Thr 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  95

Leu Pro Val Pro Leu Glu Gln Ser 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is MS

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  96

Leu Pro Val Pro Leu Glu Gln Xaa 
1               5               


<210>  97
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  97

Leu Pro Val Pro Val Asp Gln Thr 
1               5               


<210>  98
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  98

Leu Pro Val Pro Val Glu Gln Ser 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  99

Leu Pro Val Pro Val Asp Gln Ser 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  100

Val Pro Val Pro Leu Asp Gln Thr 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  101

Leu Pro Leu Pro Leu Asp Gln Ser 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  102

Val Pro Leu Pro Leu Asp Gln Ser 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  103

Leu Pro Leu Pro Leu Asp Gln Thr 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is NYP

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is NYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  104

Val Xaa Leu Xaa Val Glu Gln Ser 
1               5               


<210>  105
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  105

Val Pro Leu Pro Val Glu Gln Ser 
1               5               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  106

Leu Pro Leu Pro Leu Glu Gln Ser 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is mV

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  107

Leu Pro Xaa Pro Leu Asp Gln Ser 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  108

Leu Pro Xaa Pro Leu Asp Gln Thr 
1               5               


<210>  109
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  109

Leu Pro Xaa Pro Val Glu Gln Ser 
1               5               


<210>  110
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  110

Leu Pro Xaa Pro Val Glu Gln Ser 
1               5               


<210>  111
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  111

Leu Xaa Xaa Xaa Leu Glu Gln Ser 
1               5               


<210>  112
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  112

Leu Xaa Xaa Xaa Val Glu Gln Ser 
1               5               


<210>  113
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  113

Leu Pro Val Pro Leu Asp Gln Thr 
1               5               


<210>  114
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  114

Asp Gln Thr Leu Pro Leu Asn Val Asn Pro 
1               5                   10  


<210>  115
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  115

Leu Pro Val Pro Leu Asp Gln Thr Leu Pro Leu 
1               5                   10      


<210>  116
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa si P or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is V or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is P or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is L or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Q or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is T or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  116

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L, Nle or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Pro, HYP, 2PP or DHP

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is V, L, Nle or mV

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Pro, HYP, 2PP or DHP

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is L, Nle or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D or E

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Q or N

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is T, S or MS

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  117

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  118
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is P or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is V or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa os P or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is L or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Q or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is T or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is T or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is L or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is P or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is N or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is V or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is N or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is P or a conservative substitution with a natural or 
       non-natural amino acid

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  118

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  119
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  119

Leu Pro Val Pro Leu Asp Gln Thr Leu Pro Leu Asn Val Asn Pro 
1               5                   10                  15  


<210>  120
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  120

Leu Pro Val Pro Leu Asp Gln Thr 
1               5               


<210>  121
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  121

Xaa Pro Val Pro Leu Asp Gln Thr 
1               5               


<210>  122
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  122

Leu Pro Xaa Pro Leu Asp Gln Thr 
1               5               


<210>  123
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  123

Leu Pro Val Pro Xaa Asp Gln Thr 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  124

Leu Pro Val Pro Leu Asp Asn Thr 
1               5               


<210>  125
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  125

Leu Pro Val Pro Leu Glu Gln Thr 
1               5               


<210>  126
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  126

Leu Pro Val Pro Leu Asp Gln Ser 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  127

Leu Pro Ile Pro Leu Asp Gln Thr 
1               5               


<210>  128
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  128

Xaa Xaa Leu Pro Ile Pro Leu Asp Gln Thr Xaa Xaa 
1               5                   10          


<210>  129
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ahp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  129

Leu Pro Xaa Pro Leu Asp Gln Thr 
1               5               


<210>  130
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  130

Leu Pro Phe Pro Leu Asp Gln Thr 
1               5               


<210>  131
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  131

Xaa Xaa Leu Xaa Xaa Pro Leu Asp Gln Thr Xaa Xaa 
1               5                   10          


<210>  132
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is HYP

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  132

Xaa Xaa Leu Pro Xaa Xaa Leu Asp Gln Thr Xaa Xaa 
1               5                   10          


<210>  133
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  133

Gly Gly Leu Pro Xaa Pro Leu Asp Gln Thr Leu Pro Leu Asn Val Asn 
1               5                   10                  15      


Pro Ala 
        


<210>  134
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  134

Leu Pro Ile Pro Leu Asp Gln Thr 
1               5               


<210>  135
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  135

Xaa Leu Pro Xaa Pro Leu Asp Gln Thr Xaa 
1               5                   10  


<210>  136
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is DHP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  136

Leu Xaa Val Pro Leu Asp Gln Thr 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  137

Val Pro Val Pro Leu Asp Gln Ser 
1               5               


<210>  138
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  138

Gly Gly Leu Pro Ile Pro Leu Asp Gln Thr Leu Pro Leu Asn Val Asn 
1               5                   10                  15      


Pro Ala 
        


<210>  139
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is HYP

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  139

Leu Xaa Ile Pro Leu Asp Gln Thr 
1               5               


<210>  140
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  140

Gly Gly Leu Pro Ile Pro Leu Asp Gln Thr Leu Pro Leu Asn Val Asn 
1               5                   10                  15      


Pro Ala 
        


<210>  141
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  141

Xaa Xaa Leu Pro Leu Pro Leu Asp Gln Thr Xaa Xaa 
1               5                   10          


<210>  142
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  142

Xaa Xaa Leu Pro Xaa Pro Leu Asp Gln Thr Xaa Xaa 
1               5                   10          


<210>  143
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  ADG negative control peptide sequence


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  143

Ala Asp Gly Gly Leu Leu Leu Leu Asn Asn Pro Pro Pro Pro Gln Thr 
1               5                   10                  15      


Val Val 
        


<210>  144
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Sodium channel activity inhibiting peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  144

Xaa Leu Pro Ile Pro Leu Glu Gln Ser Xaa 
1               5                   10  


