                         SEQUENCE LISTING

<110>  Virginia Commonwealth University
 
<120>  STAGE SPECIFIC DIAGNOSTIC ANTIGENS AND ASSAY FOR LYME DISEASE

<130>  02941022

<150>  62/061,276
<151>  2014-10-08

<150>  62/199,084
<151>  2015-07-30

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic chimeric antigenic polypeptide comprising OspC epitopes

<400>  1

Ala Lys Leu Lys Gly Glu His Thr Asp Leu Gly Lys Glu Gly Val Thr 
1               5                   10                  15      


Lys Gly Ala Asp Glu Leu Glu Lys Leu Phe Glu Ser Val Lys Asn Leu 
            20                  25                  30          


Ser Lys Ala Ala Lys Glu Met Leu Thr Asn Ser Val Lys Glu Ser Glu 
        35                  40                  45              


Lys Phe Ala Gly Lys Leu Lys Asn Glu His Ala Ser Leu Gly Lys Lys 
    50                  55                  60                  


Asp Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp Leu Ser Asp Ser Val 
65                  70                  75                  80  


Glu Ser Leu Val Lys Ala Ser Asp Asp Phe Thr Lys Lys Leu Gln Ser 
                85                  90                  95      


Ser His Ala Gln Leu Gly Val Ala Gly Gly Ala Thr Thr Ala Asp Glu 
            100                 105                 110         


Leu Glu Lys Leu Phe Lys Ser Val Glu Ser Leu Ala Lys Ala Ala Gln 
        115                 120                 125             


Asp Ala Leu Ala Asn Ser Val Asn Glu Leu Thr Ser Lys Lys Leu Lys 
    130                 135                 140                 


Glu Lys His Thr Asp Leu Gly Lys Lys Asp Ala Thr Ala Ala Glu Leu 
145                 150                 155                 160 


Glu Lys Leu Phe Glu Ser Val Glu Asn Leu Ala Lys Ala Ala Lys Glu 
                165                 170                 175     


Met Leu Ser Asn Ser Asn Lys Ala Phe Thr Asp Lys Leu Lys Ser Ser 
            180                 185                 190         


His Ala Glu Leu Gly Ile Ala Asn Gly Ala Ala Thr Lys Gly Ala Gln 
        195                 200                 205             


Glu Leu Glu Lys Leu Phe Glu Ser Val Lys Asn Leu Ser Lys Ala Ala 
    210                 215                 220                 


Gln Glu Thr Leu Asn Asn Ser Val Lys Glu Ser Glu Ser Phe Thr Lys 
225                 230                 235                 240 


Lys Leu Ser Asp Asn Gln Ala Glu Leu Gly Ile Glu Asn Ala Thr Lys 
                245                 250                 255     


Gly Ala Glu Glu Leu Val Lys Leu Ser Glu Ser Val Ala Gly Leu Leu 
            260                 265                 270         


Lys Ala Ala Gln Ala Ile Leu Ala Asn Ser Val Lys Glu Leu Thr Ser 
        275                 280                 285             


Pro Val Val Ala Glu Ser Pro Lys Lys Pro Asn Asn Ser Gly Lys Asp 
    290                 295                 300                 


Gly Asn Thr Ser Ala Asn Ser Ala Asp Glu Ser Val Lys Gly Pro Asn 
305                 310                 315                 320 


Leu Thr Glu Ile Ser Lys Lys Ile Thr Glu Ser Asn Ala Val Val Leu 
                325                 330                 335     


Ala Val Lys Glu Ile Glu Thr Leu Leu Ser Ser Ile Asp Glu Leu Ala 
            340                 345                 350         


Thr Lys Ala Ile Gly Gln Lys Ile Asp Ala Asn Gly Leu Gly Val Gln 
        355                 360                 365             


Ala Asn Gln Asn Gly Ser Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr 
    370                 375                 380                 


Leu Ile Thr Gln Lys Leu Ser Ala Leu Asn Ser Glu Asp Leu Lys Glu 
385                 390                 395                 400 


Lys Val Ala Lys Val Lys Lys Cys Ser Glu Asp Phe Thr Asn Lys Leu 
                405                 410                 415     


Lys Asn Gly Asn Ala Gln Leu Gly Leu Ala Ala Ala Thr Asp Asp Asn 
            420                 425                 430         


Ala Lys Ala Ala Ile Leu Lys Thr Asn Gly Thr Asn Asp Lys Gly Ala 
        435                 440                 445             


Lys Glu Leu Lys Asp Leu Ser Asp Ser Val Glu Ser Leu Val Lys Ala 
    450                 455                 460                 


Ala Gln Val Met Leu Thr Asn Ser Val Lys Glu Leu Thr Ser Pro Val 
465                 470                 475                 480 


Val Ala Glu Ser Pro Lys Lys Pro 
                485             


<210>  2
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic chimeric antigenic polypeptide comprising OspC epitopes

<400>  2

Ser Thr Gly Phe Thr Asn Lys Leu Lys Ser Gly His Ala Glu Leu Gly 
1               5                   10                  15      


Pro Val Gly Gly Asn Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp Leu 
            20                  25                  30          


Ser Glu Ser Val Glu Ala Leu Ala Lys Ala Ala Gln Ala Met Leu Thr 
        35                  40                  45              


Asn Ser Ser Glu Lys Phe Thr Lys Lys Leu Ser Glu Ser His Ala Asp 
    50                  55                  60                  


Ile Gly Ile Gln Ala Ala Thr Lys Gly Ala Glu Glu Leu Asp Lys Leu 
65                  70                  75                  80  


Phe Lys Ala Val Glu Asn Leu Ser Lys Ser Glu Glu Phe Ser Thr Lys 
                85                  90                  95      


Leu Lys Asp Asn His Ala Gln Leu Gly Ile Gln Gly Val Thr Lys Gly 
            100                 105                 110         


Val Glu Glu Leu Glu Lys Leu Ser Gly Ser Leu Glu Ser Leu Ser Ser 
        115                 120                 125             


Thr Glu Phe Thr Asn Lys Leu Lys Ser Glu His Ala Val Leu Gly Leu 
    130                 135                 140                 


Asp Asn Leu Thr Lys Gly Ala Ala Glu Leu Glu Lys Leu Phe Lys Ala 
145                 150                 155                 160 


Val Glu Asn Leu Ser Lys Ala Ala Gln Asp Thr Leu Lys Asn Ala Val 
                165                 170                 175     


Lys Glu Leu Thr Ser Pro Ile Val Ala Glu Ser Pro Lys Lys Pro Ser 
            180                 185                 190         


Glu Asp Phe Thr Lys Lys Leu Glu Gly Glu His Ala Gln Leu Gly Ile 
        195                 200                 205             


Glu Asn Val Thr Ala Ala Glu Leu Glu Lys Leu Phe Lys Ala Val Glu 
    210                 215                 220                 


Asn Leu Ala Lys Ala Ala Lys Glu Met Ser Glu Lys Phe Ala Gly Lys 
225                 230                 235                 240 


Leu Lys Asn Glu His Ala Ser Leu Gly Lys Lys Asp Ala Thr Lys Gly 
                245                 250                 255     


Ala Lys Glu Leu Lys Asp Leu Ser Asp Ser Val Glu Ser Leu Val Lys 
            260                 265                 270         


Ala Ser Asp Asp Phe Thr Lys Lys Leu Gln Ser Ser His Ala Gln Leu 
        275                 280                 285             


Gly Val Ala Gly Gly Ala Thr Thr Ala Asp Glu Leu Glu Lys Leu Phe 
    290                 295                 300                 


Lys Ser Val Glu Ser Leu Ala Lys Ala Ala Gln Asp Ala Leu Ala Asn 
305                 310                 315                 320 


Ser Val Asn Glu Leu Thr Ser Lys Lys Leu Lys Glu Lys His Thr Asp 
                325                 330                 335     


Leu Gly Lys Lys Asp Ala Thr Ala Ala Glu Leu Glu Lys Leu Phe Glu 
            340                 345                 350         


Ser Val Glu Asn Leu Ala Lys Ala Ala Lys Glu Met Leu Ser Asn Ser 
        355                 360                 365             


Asn Lys Ala Phe Thr Asp Lys Leu Lys Ser Ser His Ala Glu Leu Gly 
    370                 375                 380                 


Ile Ala Asn Gly Ala Ala Thr Lys Gly Ala Gln Glu Leu Glu Lys Leu 
385                 390                 395                 400 


Phe Glu Ser Val Lys Asn Leu Ser Lys Ala Ala Gln Glu Thr Leu Asn 
                405                 410                 415     


Asn Ser Val Lys Glu Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala 
            420                 425                 430         


Asn Ser Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser 
        435                 440                 445             


Lys Lys Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Gln Val 
    450                 455                 460                 


Glu Ala Leu Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly 
465                 470                 475                 480 


Lys Lys Ile His Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn His Asn 
                485                 490                 495     


Gly Ser Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln 
            500                 505                 510         


Lys Leu Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile Asp Ala 
        515                 520                 525             


Ala Lys Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu Lys Glu Lys His 
    530                 535                 540                 


Thr Asp Leu Gly Lys Glu Gly Val Thr Asp Ala Asp Ala Lys Glu Ala 
545                 550                 555                 560 


Ile Leu Lys Thr Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly 
                565                 570                 575     


Lys Leu Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met 
            580                 585                 590         


Leu Ala Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser 
        595                 600                 605             


Pro Lys Lys Pro 
    610         


<210>  3
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic chimeric antigenic polypeptide comprising OspC epitopes

<400>  3

Ser Glu Thr Phe Thr Asn Lys Leu Lys Glu Lys His Thr Asp Leu Gly 
1               5                   10                  15      


Lys Glu Gly Val Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu Phe Glu 
            20                  25                  30          


Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala Asn Ser 
        35                  40                  45              


Val Lys Glu Leu Thr Ser Ser Glu Glu Phe Ser Thr Lys Leu Lys Asp 
    50                  55                  60                  


Asn His Ala Gln Leu Gly Ile Gln Gly Val Thr Lys Gly Val Glu Glu 
65                  70                  75                  80  


Leu Glu Lys Leu Ser Gly Ser Leu Glu Ser Leu Ser Ser Glu Asp Phe 
                85                  90                  95      


Thr Lys Lys Leu Glu Gly Glu His Ala Gln Leu Gly Ile Glu Asn Val 
            100                 105                 110         


Thr Ala Ala Glu Leu Glu Lys Leu Phe Lys Ala Val Glu Asn Leu Ala 
        115                 120                 125             


Lys Ala Ala Lys Glu Met Ala Lys Leu Lys Gly Glu His Thr Asp Leu 
    130                 135                 140                 


Gly Lys Glu Gly Val Thr Lys Gly Ala Asp Glu Leu Glu Lys Leu Phe 
145                 150                 155                 160 


Glu Ser Val Lys Asn Leu Ser Lys Ala Ala Lys Glu Met Leu Thr Asn 
                165                 170                 175     


Ser Lys Glu Ser Glu Lys Phe Ala Gly Lys Leu Lys Asn Glu His Ala 
            180                 185                 190         


Ser Leu Gly Lys Lys Asp Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp 
        195                 200                 205             


Leu Ser Asp Ser Val Glu Ser Leu Val Lys Ala Ser Asp Asp Phe Thr 
    210                 215                 220                 


Lys Lys Leu Gln Ser Ser His Ala Gln Leu Gly Val Ala Gly Gly Ala 
225                 230                 235                 240 


Thr Thr Ala Asp Glu Leu Glu Lys Leu Phe Lys Ser Val Glu Ser Leu 
                245                 250                 255     


Ala Lys Ala Ala Gln Asp Ala Leu Ala Asn Ser Val Asn Glu Leu Thr 
            260                 265                 270         


Ser Lys Lys Leu Lys Glu Lys His Thr Asp Leu Gly Lys Lys Asp Ala 
        275                 280                 285             


Thr Ala Ala Glu Leu Glu Lys Leu Phe Glu Ser Val Glu Asn Leu Ala 
    290                 295                 300                 


Lys Ala Ala Lys Glu Met Leu Ser Asn Ser Asn Lys Ala Phe Thr Asp 
305                 310                 315                 320 


Lys Leu Lys Ser Ser His Ala Glu Leu Gly Ile Ala Asn Gly Ala Ala 
                325                 330                 335     


Thr Lys Gly Ala Gln Glu Leu Glu Lys Leu Phe Glu Ser Val Lys Asn 
            340                 345                 350         


Leu Ser Lys Ala Ala Gln Glu Thr Leu Asn Asn Ser Val Lys Glu Ser 
        355                 360                 365             


Glu Ser Phe Thr Lys Lys Leu Ser Asp Asn Gln Ala Glu Leu Gly Ile 
    370                 375                 380                 


Glu Asn Ala Thr Lys Gly Ala Glu Glu Leu Val Lys Leu Ser Glu Ser 
385                 390                 395                 400 


Val Ala Gly Leu Leu Lys Ala Ala Gln Ala Ile Leu Ala Asn Ser Val 
                405                 410                 415     


Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Lys Lys Pro 
            420                 425                 430     


<210>  4
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic chimeric antigenic polypeptide comprising OspC epitopes

<400>  4

Ser Glu Lys Phe Thr Thr Lys Leu Lys Asp Ser His Ala Glu Leu Gly 
1               5                   10                  15      


Ile Gln Ser Val Gln Asp Lys Gly Ala Lys Glu Leu Glu Glu Leu Phe 
            20                  25                  30          


Lys Ser Leu Glu Ser Leu Ser Lys Ala Ala Gln Ala Ala Leu Thr Asn 
        35                  40                  45              


Ser Val Lys Glu Leu Thr Asn Ser Asp Lys Phe Thr Lys Lys Leu Thr 
    50                  55                  60                  


Asp Ser His Ala Gln Leu Gly Ala Val Gly Gly Ala Ile Asn Asp Lys 
65                  70                  75                  80  


Gly Ala Lys Glu Leu Lys Glu Leu Ser Glu Ser Val Glu Ser Leu Ala 
                85                  90                  95      


Lys Ala Ala Gln Ala Ala Leu Ala Asn Ser Ser Glu Ala Phe Thr Lys 
            100                 105                 110         


Lys Leu Lys Asp Ser Asn Ala Gln Leu Gly Met Gln Asn Gly Ala Ala 
        115                 120                 125             


Thr Asp Lys Gly Ala Thr Glu Leu Gly Glu Leu Phe Lys Ser Val Glu 
    130                 135                 140                 


Ser Leu Ser Lys Ala Ala Gln Glu Ala Ser Val Ala Phe Thr Ser Lys 
145                 150                 155                 160 


Leu Lys Ser Ser Asn Ala Gln Leu Gly Val Ala Asn Gly Asn Ala Thr 
                165                 170                 175     


Asp Lys Gly Ala Lys Glu Leu Lys Glu Leu Phe Glu Ser Val Glu Ser 
            180                 185                 190         


Leu Ala Lys Ala Ala Gln Ala Ala Leu Val Asn Ser Val Gln Glu Leu 
        195                 200                 205             


Thr Asn Ser Glu Ala Phe Thr Asn Arg Leu Lys Gly Ser His Ala Gln 
    210                 215                 220                 


Leu Gly Val Ala Ala Ala Thr Asp Lys Gly Ala Lys Glu Leu Lys Asp 
225                 230                 235                 240 


Leu Ser Glu Ser Val Glu Ser Leu Ala Lys Ala Ala Gln Glu Ala Leu 
                245                 250                 255     


Ala Asn Ser Val Lys Glu Leu Thr Asn Ser Glu Ala Phe Thr Asn Lys 
            260                 265                 270         


Leu Lys Glu Lys His Ala Glu Leu Gly Val Asn Gly Gly Asp Thr Thr 
        275                 280                 285             


Asp Lys Gly Val Glu Asp Leu Glu Lys Leu Ser Glu Ser Val Lys Ser 
    290                 295                 300                 


Leu Leu Lys Ala Ala Gln Ala Ala Leu Ser Asn Ser Ala Ala Phe Thr 
305                 310                 315                 320 


Lys Lys Leu Gln Asp Gly His Val Asp Leu Gly Lys Thr Asp Val Thr 
                325                 330                 335     


Thr Lys Gly Ala Thr Glu Leu Glu Glu Leu Phe Lys Ser Val Glu Gly 
            340                 345                 350         


Leu Val Lys Ala Ala Lys Glu Ala Ser Glu Thr Phe Thr Asn Lys Leu 
        355                 360                 365             


Lys Glu Lys His Thr Asp Leu Gly Lys Glu Gly Val Thr Lys Gly Ala 
    370                 375                 380                 


Glu Glu Leu Gly Lys Leu Phe Glu Ser Val Glu Val Leu Ser Lys Ala 
385                 390                 395                 400 


Ala Lys Glu Met Leu Ala Asn Ser Val Lys Glu Leu Thr Ser Ser Glu 
                405                 410                 415     


Asp Phe Thr Lys Lys Leu Glu Gly Glu His Ala Gln Leu Gly Ile Glu 
            420                 425                 430         


Asn Val Thr Ala Ala Glu Leu Glu Lys Leu Phe Lys Ala Val Glu Asn 
        435                 440                 445             


Leu Ala Lys Ala Ala Lys Glu Met Ala Pro Val Val Ala Glu Ser Pro 
    450                 455                 460                 


Lys Lys Pro 
465         


<210>  5
<211>  823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic chimeric antigenic polypeptide comprising OspC epitopes

<400>  5

Ser Glu Asp Phe Thr Asn Lys Leu Lys Asn Gly Asn Ala Gln Leu Gly 
1               5                   10                  15      


Leu Ala Ala Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp Leu Ser Asp 
            20                  25                  30          


Ser Val Glu Ser Leu Val Lys Ala Ala Gln Val Met Leu Thr Asn Ser 
        35                  40                  45              


Ser Thr Gly Phe Thr Asn Lys Leu Lys Ser Gly His Ala Glu Leu Gly 
    50                  55                  60                  


Pro Val Gly Gly Asn Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp Leu 
65                  70                  75                  80  


Ser Glu Ser Val Glu Ala Leu Ala Lys Ala Ala Gln Ala Met Leu Thr 
                85                  90                  95      


Asn Ser Ser Glu Lys Phe Thr Lys Lys Leu Ser Glu Ser His Ala Asp 
            100                 105                 110         


Ile Gly Ile Gln Ala Ala Thr Lys Gly Ala Glu Glu Leu Asp Lys Leu 
        115                 120                 125             


Phe Lys Ala Val Glu Asn Leu Ser Lys Ser Thr Glu Phe Thr Asn Lys 
    130                 135                 140                 


Leu Lys Ser Glu His Ala Val Leu Gly Leu Asp Asn Leu Thr Lys Gly 
145                 150                 155                 160 


Ala Ala Glu Leu Glu Lys Leu Phe Lys Ala Val Glu Asn Leu Ser Lys 
                165                 170                 175     


Ala Ala Gln Asp Thr Leu Lys Asn Ala Val Lys Glu Leu Thr Ser Pro 
            180                 185                 190         


Ile Val Ala Glu Ser Pro Lys Lys Pro Ser Glu Thr Phe Thr Asn Lys 
        195                 200                 205             


Leu Lys Glu Lys His Thr Asp Leu Gly Lys Glu Gly Val Thr Lys Gly 
    210                 215                 220                 


Ala Glu Glu Leu Gly Lys Leu Phe Glu Ser Val Glu Val Leu Ser Lys 
225                 230                 235                 240 


Ala Ala Lys Glu Met Leu Ala Asn Ser Val Lys Glu Leu Thr Ser Ser 
                245                 250                 255     


Glu Glu Phe Ser Thr Lys Leu Lys Asp Asn His Ala Gln Leu Gly Ile 
            260                 265                 270         


Gln Gly Val Thr Lys Gly Val Glu Glu Leu Glu Lys Leu Ser Gly Ser 
        275                 280                 285             


Leu Glu Ser Leu Ser Ser Glu Asp Phe Thr Lys Lys Leu Glu Gly Glu 
    290                 295                 300                 


His Ala Gln Leu Gly Ile Glu Asn Val Thr Ala Ala Glu Leu Glu Lys 
305                 310                 315                 320 


Leu Phe Lys Ala Val Glu Asn Leu Ala Lys Ala Ala Lys Glu Met Ala 
                325                 330                 335     


Lys Leu Lys Gly Glu His Thr Asp Leu Gly Lys Glu Gly Val Thr Lys 
            340                 345                 350         


Gly Ala Asp Glu Leu Glu Lys Leu Phe Glu Ser Val Lys Asn Leu Ser 
        355                 360                 365             


Lys Ala Ala Lys Glu Met Leu Thr Asn Ser Val Lys Glu Ser Glu Lys 
    370                 375                 380                 


Phe Ala Gly Lys Leu Lys Asn Glu His Ala Ser Leu Gly Lys Lys Asp 
385                 390                 395                 400 


Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp Leu Ser Asp Ser Val Glu 
                405                 410                 415     


Ser Leu Val Lys Ala Ser Asp Asp Phe Thr Lys Lys Leu Gln Ser Ser 
            420                 425                 430         


His Ala Gln Leu Gly Val Ala Gly Gly Ala Thr Thr Ala Asp Glu Leu 
        435                 440                 445             


Glu Lys Leu Phe Lys Ser Val Glu Ser Leu Ala Lys Ala Ala Gln Asp 
    450                 455                 460                 


Ala Leu Ala Asn Ser Val Asn Glu Leu Thr Ser Lys Lys Leu Lys Glu 
465                 470                 475                 480 


Lys His Thr Asp Leu Gly Lys Lys Asp Ala Thr Ala Ala Glu Leu Glu 
                485                 490                 495     


Lys Leu Phe Glu Ser Val Glu Asn Leu Ala Lys Ala Ala Lys Glu Met 
            500                 505                 510         


Leu Ser Asn Ser Asn Lys Ala Phe Thr Asp Lys Leu Lys Ser Ser His 
        515                 520                 525             


Ala Glu Leu Gly Ile Ala Asn Gly Ala Ala Thr Lys Gly Ala Gln Glu 
    530                 535                 540                 


Leu Glu Lys Leu Phe Glu Ser Val Lys Asn Leu Ser Lys Ala Ala Gln 
545                 550                 555                 560 


Glu Thr Leu Asn Asn Ser Val Lys Glu Ser Glu Ser Phe Thr Lys Lys 
                565                 570                 575     


Leu Ser Asp Asn Gln Ala Glu Leu Gly Ile Glu Asn Ala Thr Lys Gly 
            580                 585                 590         


Ala Glu Glu Leu Val Lys Leu Ser Glu Ser Val Ala Gly Leu Leu Lys 
        595                 600                 605             


Ala Ala Gln Ala Ile Leu Ala Asn Ser Val Lys Glu Leu Thr Ser Pro 
    610                 615                 620                 


Val Val Ala Glu Ser Pro Lys Lys Pro Asn Asn Ser Gly Lys Asp Gly 
625                 630                 635                 640 


Asn Thr Ser Ala Asn Ser Ala Asp Glu Ser Val Lys Gly Pro Asn Leu 
                645                 650                 655     


Thr Glu Ile Ser Lys Lys Ile Thr Glu Ser Asn Ala Val Val Leu Ala 
            660                 665                 670         


Val Lys Glu Ile Glu Thr Leu Leu Ser Ser Ile Asp Glu Leu Ala Thr 
        675                 680                 685             


Lys Ala Ile Gly Gln Lys Ile Asp Ala Asn Gly Leu Gly Val Gln Ala 
    690                 695                 700                 


Asn Gln Asn Gly Ser Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu 
705                 710                 715                 720 


Ile Thr Gln Lys Leu Ser Ala Leu Asn Ser Glu Asp Leu Lys Glu Lys 
                725                 730                 735     


Val Ala Lys Val Lys Lys Cys Ser Glu Asp Phe Thr Asn Lys Leu Lys 
            740                 745                 750         


Asn Gly Asn Ala Gln Leu Gly Leu Ala Ala Ala Thr Asp Asp Asn Ala 
        755                 760                 765             


Lys Ala Ala Ile Leu Lys Thr Asn Gly Thr Asn Asp Lys Gly Ala Lys 
    770                 775                 780                 


Glu Leu Lys Asp Leu Ser Asp Ser Val Glu Ser Leu Val Lys Ala Ala 
785                 790                 795                 800 


Gln Val Met Leu Thr Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val 
                805                 810                 815     


Ala Glu Ser Pro Lys Lys Pro 
            820             


<210>  6
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic chimeric antigenic polypeptide comprising OspC epitopes

<400>  6

Ser Glu Asp Phe Thr Asn Lys Leu Lys Asn Gly Asn Ala Gln Leu Gly 
1               5                   10                  15      


Leu Ala Ala Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp Leu Ser Asp 
            20                  25                  30          


Ser Val Glu Ser Leu Val Lys Ala Ala Gln Val Met Leu Thr Asn Ser 
        35                  40                  45              


Ser Thr Gly Phe Thr Asn Lys Leu Lys Ser Gly His Ala Glu Leu Gly 
    50                  55                  60                  


Pro Val Gly Gly Asn Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp Leu 
65                  70                  75                  80  


Ser Glu Ser Val Glu Ala Leu Ala Lys Ala Ala Gln Ala Met Leu Thr 
                85                  90                  95      


Asn Ser Ser Glu Lys Phe Thr Lys Lys Leu Ser Glu Ser His Ala Asp 
            100                 105                 110         


Ile Gly Ile Gln Ala Ala Thr Lys Gly Ala Glu Glu Leu Asp Lys Leu 
        115                 120                 125             


Phe Lys Ala Val Glu Asn Leu Ser Lys Ser Thr Glu Phe Thr Asn Lys 
    130                 135                 140                 


Leu Lys Ser Glu His Ala Val Leu Gly Leu Asp Asn Leu Thr Lys Gly 
145                 150                 155                 160 


Ala Ala Glu Leu Glu Lys Leu Phe Lys Ala Val Glu Asn Leu Ser Lys 
                165                 170                 175     


Ala Ala Gln Asp Thr Leu Lys Asn Ala Val Lys Glu Leu Thr Ser Pro 
            180                 185                 190         


Ile Val Ala Glu Ser Pro Lys Lys Pro Ser Glu Thr Phe Thr Asn Lys 
        195                 200                 205             


Leu Lys Glu Lys His Thr Asp Leu Gly Lys Glu Gly Val Thr Lys Gly 
    210                 215                 220                 


Ala Glu Glu Leu Gly Lys Leu Phe Glu Ser Val Glu Val Leu Ser Lys 
225                 230                 235                 240 


Ala Ala Lys Glu Met Leu Ala Asn Ser Val Lys Glu Leu Thr Ser Ser 
                245                 250                 255     


Glu Glu Phe Ser Thr Lys Leu Lys Asp Asn His Ala Gln Leu Gly Ile 
            260                 265                 270         


Gln Gly Val Thr Lys Gly Val Glu Glu Leu Glu Lys Leu Ser Gly Ser 
        275                 280                 285             


Leu Glu Ser Leu Ser Ser Glu Asp Phe Thr Lys Lys Leu Glu Gly Glu 
    290                 295                 300                 


His Ala Gln Leu Gly Ile Glu Asn Val Thr Ala Ala Glu Leu Glu Lys 
305                 310                 315                 320 


Leu Phe Lys Ala Val Glu Asn Leu Ala Lys Ala Ala Lys Glu Met 
                325                 330                 335 


<210>  7
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic chimeric antigenic polypeptide comprising OspC epitopes

<400>  7

Ala Lys Leu Lys Gly Glu His Thr Asp Leu Gly Lys Glu Gly Val Thr 
1               5                   10                  15      


Lys Gly Ala Asp Glu Leu Glu Lys Leu Phe Glu Ser Val Lys Asn Leu 
            20                  25                  30          


Ser Lys Ala Ala Lys Glu Met Leu Thr Asn Ser Val Lys Glu Ser Glu 
        35                  40                  45              


Lys Phe Ala Gly Lys Leu Lys Asn Glu His Ala Ser Leu Gly Lys Lys 
    50                  55                  60                  


Asp Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp Leu Ser Asp Ser Val 
65                  70                  75                  80  


Glu Ser Leu Val Lys Ala Ser Asp Asp Phe Thr Lys Lys Leu Gln Ser 
                85                  90                  95      


Ser His Ala Gln Leu Gly Val Ala Gly Gly Ala Thr Thr Ala Asp Glu 
            100                 105                 110         


Leu Glu Lys Leu Phe Lys Ser Val Glu Ser Leu Ala Lys Ala Ala Gln 
        115                 120                 125             


Asp Ala Leu Ala Asn Ser Val Asn Glu Leu Thr Ser Lys Lys Leu Lys 
    130                 135                 140                 


Glu Lys His Thr Asp Leu Gly Lys Lys Asp Ala Thr Ala Ala Glu Leu 
145                 150                 155                 160 


Glu Lys Leu Phe Glu Ser Val Glu Asn Leu Ala Lys Ala Ala Lys Glu 
                165                 170                 175     


Met Leu Ser Asn Ser Asn Lys Ala Phe Thr Asp Lys Leu Lys Ser Ser 
            180                 185                 190         


His Ala Glu Leu Gly Ile Ala Asn Gly Ala Ala Thr Lys Gly Ala Gln 
        195                 200                 205             


Glu Leu Glu Lys Leu Phe Glu Ser Val Lys Asn Leu Ser Lys Ala Ala 
    210                 215                 220                 


Gln Glu Thr Leu Asn Asn Ser Val Lys Glu Ser Glu Ser Phe Thr Lys 
225                 230                 235                 240 


Lys Leu Ser Asp Asn Gln Ala Glu Leu Gly Ile Glu Asn Ala Thr Lys 
                245                 250                 255     


Gly Ala Glu Glu Leu Val Lys Leu Ser Glu Ser Val Ala Gly Leu Leu 
            260                 265                 270         


Lys Ala Ala Gln Ala Ile Leu Ala Asn Ser Val Lys Glu Leu Thr Ser 
        275                 280                 285             


Pro Val Val Ala Glu Ser Pro Lys Lys Pro 
    290                 295             


<210>  8
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic chimeric antigenic polypeptide comprising OspC epitopes

<400>  8

Ala Lys Leu Lys Gly Glu His Thr Asp Leu Gly Lys Glu Gly Val Thr 
1               5                   10                  15      


Lys Gly Ala Asp Glu Leu Glu Lys Leu Phe Glu Ser Val Lys Asn Leu 
            20                  25                  30          


Ser Lys Ala Ala Lys Glu Met Leu Thr Asn Ser Val Lys Glu Ser Glu 
        35                  40                  45              


Lys Phe Ala Gly Lys Leu Lys Asn Glu His Ala Ser Leu Gly Lys Lys 
    50                  55                  60                  


Asp Ala Thr Lys Gly Ala Lys Glu Leu Lys Asp Leu Ser Asp Ser Val 
65                  70                  75                  80  


Glu Ser Leu Val Lys Ala Ser Asp Asp Phe Thr Lys Lys Leu Gln Ser 
                85                  90                  95      


Ser His Ala Gln Leu Gly Val Ala Gly Gly Ala Thr Thr Ala Asp Glu 
            100                 105                 110         


Leu Glu Lys Leu Phe Lys Ser Val Glu Ser Leu Ala Lys Ala Ala Gln 
        115                 120                 125             


Asp Ala Leu Ala Asn Ser Val Asn Glu Leu Thr Ser Lys Lys Leu Lys 
    130                 135                 140                 


Glu Lys His Thr Asp Leu Gly Lys Lys Asp Ala Thr Ala Ala Glu Leu 
145                 150                 155                 160 


Glu Lys Leu Phe Glu Ser Val Glu Asn Leu Ala Lys Ala Ala Lys Glu 
                165                 170                 175     


Met Leu Ser Asn Ser Asn Lys Ala Phe Thr Asp Lys Leu Lys Ser Ser 
            180                 185                 190         


His Ala Glu Leu Gly Ile Ala Asn Gly Ala Ala Thr Lys Gly Ala Gln 
        195                 200                 205             


Glu Leu Glu Lys Leu Phe Glu Ser Val Lys Asn Leu Ser Lys Ala Ala 
    210                 215                 220                 


Gln Glu Thr Leu Asn Asn Ser Val Lys Glu Ser Glu Ser Phe Thr Lys 
225                 230                 235                 240 


Lys Leu Ser Asp Asn Gln Ala Glu Leu Gly Ile Glu Asn Ala Thr Lys 
                245                 250                 255     


Gly Ala Glu Glu Leu Val Lys Leu Ser Glu Ser Val Ala Gly Leu Leu 
            260                 265                 270         


Lys Ala Ala Gln Ala Ile Leu Ala Asn Ser Val Lys Glu Leu Thr Ser 
        275                 280                 285             


Pro Val Val Ala Glu Ser Pro Lys Lys Pro Ser Thr Glu Glu Lys Phe 
    290                 295                 300                 


Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly 
305                 310                 315                 320 


Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala 
                325                 330                 335     


Lys Glu Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu 
            340                 345                 350         


Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn 
        355                 360                 365             


Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser 
    370                 375                 380                 


Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr 
385                 390                 395                 400 


Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr 
                405                 410                 415     


Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys 
            420                 425                 430         


Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn 
        435                 440                 445             


Ala Leu Lys 
    450     


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic C-terminal domain peptide

<400>  9

Pro Val Val Ala Glu Ser Pro Lys Lys Pro 
1               5                   10  


<210>  10
<211>  158
<212>  PRT
<213>  Borrelia burgdorferi

<400>  10

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Asn Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  11
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Snythetiec OspE mutant

<400>  11

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Val Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Lys Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Ser Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Val Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Cys Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  12
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  12

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Val Glu Gln Ser Asn 
1               5                   10                  15      


Gly Val Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Cys Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Ser Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  13
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  13

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Ile Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Asn Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  14
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  14

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Leu Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Asn Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  15
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  15

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Arg Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Asn Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  16
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  16

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Ser Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Val Arg Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  17
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  17

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Glu Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Lys Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Asn Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  18
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  18

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Gln Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Ala His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Ser Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Val Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  19
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  19

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Ala Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Ser Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Val Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Val 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  20
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  20

Leu Ile Gly Ala Cys Lys Ile His Pro Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Ile Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Thr Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Pro Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Ser Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Val Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  21
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  21

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Asn Pro Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Arg Tyr Asn Asp Glu Glu Ser Asp Lys Ser Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Met Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  22
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  22

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Asn 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Arg Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Pro Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Asn Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Ser Asn Leu Lys 
145                 150                 155             


<210>  23
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  23

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Pro Met Thr Glu Asp Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Asn Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu 
145 


<210>  24
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  24

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Ile Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Cys Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly His Ser Ala Thr Phe Val Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Pro Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Asn Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  25
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  25

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Glu Gly Asp Leu 
        35                  40                  45              


Val Ile Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Arg His Ser Ala Thr Phe Phe Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Pro Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Asp Lys Ser Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Val Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Arg Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Thr Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  26
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  26

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Asn 
1               5                   10                  15      


Gly Glu Val Lys Val Lys Lys Ile Glu Phe Ser Glu Phe Thr Val Lys 
            20                  25                  30          


Ile Lys Asn Lys Asn Asn Ser Asn Asn Trp Ala Asp Leu Gly Asp Leu 
        35                  40                  45              


Val Val Arg Lys Glu Lys Asp Gly Ile Glu Thr Gly Leu Asn Ala Gly 
    50                  55                  60                  


Gly Gln Leu Ala Thr Phe Leu Ser Leu Glu Glu Glu Glu Ile Asn Asn 
65                  70                  75                  80  


Phe Ile Lys Pro Met Thr Glu Gly Gly Ser Phe Lys Thr Ser Leu Tyr 
                85                  90                  95      


Tyr Gly Tyr Asn Asp Glu Glu Ser Gly Lys Asn Val Ile Lys Asn Lys 
            100                 105                 110         


Glu Ile Lys Thr Lys Ile Glu Lys Ile Asn Asp Thr Glu Tyr Ile Thr 
        115                 120                 125             


Phe Leu Gly Asp Lys Ile Asn Asn Ser Ala Gly Gly Asp Lys Ile Ala 
    130                 135                 140                 


Glu Tyr Ala Ile Ser Leu Glu Glu Leu Lys Arg Asn Leu Lys 
145                 150                 155             


<210>  27
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  27

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Ser 
1               5                   10                  15      


Gly Glu Ile Asn His Thr Leu Tyr Asp Glu Gln Ser Asn Gly Glu Leu 
            20                  25                  30          


Lys Leu Lys Lys Ile Glu Phe Ser Lys Phe Thr Val Lys Ile Lys Asn 
        35                  40                  45              


Lys Asp Asn Asn Ser Asn Trp Thr Asp Leu Gly Asp Leu Val Val Arg 
    50                  55                  60                  


Lys Glu Glu Asn Gly Ile Asp Thr Gly Leu Asn Ala Gly Gly His Ser 
65                  70                  75                  80  


Ala Thr Phe Phe Ser Leu Lys Glu Ser Glu Val Asn Asn Phe Ile Lys 
                85                  90                  95      


Ala Met Thr Lys Gly Gly Ser Phe Lys Thr Ser Leu Tyr Tyr Gly Tyr 
            100                 105                 110         


Lys Tyr Glu Gln Ser Ser Ala Asn Gly Ile Gln Asn Lys Glu Ile Ile 
        115                 120                 125             


Thr Lys Ile Glu Ser Ile Asn Gly Ala Glu His Ile Ala Phe Leu Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asn Gly Val Gly Gly Asp Lys Thr Ala Glu Tyr Ala 
145                 150                 155                 160 


Ile Pro Leu Glu Val Leu Lys Lys Asn Leu Lys 
                165                 170     


<210>  28
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  28

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Ser 
1               5                   10                  15      


Gly Glu Ile Asn His Thr Leu Tyr Asp Glu Gln Ser Asn Gly Glu Leu 
            20                  25                  30          


Lys Leu Lys Lys Ile Glu Phe Ser Lys Phe Thr Val Lys Ile Lys Asn 
        35                  40                  45              


Lys Asp Asn Asn Ser Asn Trp Thr Asp Leu Gly Asp Leu Val Val Arg 
    50                  55                  60                  


Lys Glu Glu Asn Gly Ile Asp Thr Gly Leu Asp Ala Gly Gly His Ser 
65                  70                  75                  80  


Ala Thr Phe Phe Ser Leu Lys Glu Ser Glu Val Asn Asn Phe Ile Lys 
                85                  90                  95      


Ala Met Thr Lys Gly Gly Ser Phe Lys Thr Ser Leu Tyr Tyr Gly Tyr 
            100                 105                 110         


Lys Tyr Glu Gln Ser Ser Ala Asn Gly Ile Gln Asn Lys Glu Ile Ile 
        115                 120                 125             


Thr Lys Ile Glu Ser Ile Val Gly Ala Glu His Ile Ala Phe Leu Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asn Gly Val Gly Gly Asp Lys Thr Ala Glu Tyr Val 
145                 150                 155                 160 


Ile Pro Leu Glu Val Val Lys Lys Asn Leu Lys 
                165                 170     


<210>  29
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  29

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Ser 
1               5                   10                  15      


Gly Glu Ile Asn His Thr Leu Tyr Asp Glu Gln Ser Asn Gly Glu Leu 
            20                  25                  30          


Lys Leu Lys Lys Ile Glu Phe Ser Lys Phe Thr Val Lys Ile Lys Asn 
        35                  40                  45              


Lys Asp Asn Asn Ser Asn Trp Thr Asp Leu Gly Asp Leu Val Val Arg 
    50                  55                  60                  


Lys Glu Glu Asn Gly Ile Asn Thr Gly Leu Asn Ala Gly Gly His Ser 
65                  70                  75                  80  


Asp Met Phe Phe Ser Leu Lys Glu Ser Glu Val Asn Asn Phe Ile Lys 
                85                  90                  95      


Ala Met Thr Lys Gly Gly Ser Phe Lys Thr Ser Leu Tyr Tyr Gly Tyr 
            100                 105                 110         


Lys Tyr Glu Gln Ser Ser Ala Asn Gly Ile Gln Asn Lys Glu Ile Ile 
        115                 120                 125             


Thr Lys Ile Glu Ser Ile Asn Gly Ala Glu His Ile Ala Val Leu Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asn Gly Val Gly Gly Asp Lys Thr Ala Glu Tyr Ala 
145                 150                 155                 160 


Ile Pro Leu Glu Val Leu Lys Lys Asn Leu Lys 
                165                 170     


<210>  30
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  30

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Ser 
1               5                   10                  15      


Val Glu Ile Asn His Thr Leu Tyr Asp Glu Gln Ser Asn Gly Glu Leu 
            20                  25                  30          


Lys Leu Lys Lys Ile Glu Phe Ser Lys Phe Thr Val Lys Ile Lys Asn 
        35                  40                  45              


Lys Asp Asn Asn Ser Asn Trp Thr Asp Leu Gly Asp Leu Val Val Arg 
    50                  55                  60                  


Lys Glu Glu Asn Gly Ile Asp Thr Gly Leu Asn Ala Gly Glu His Ser 
65                  70                  75                  80  


Ala Thr Phe Phe Ser Leu Lys Glu Ser Glu Val Asn Asn Phe Ile Lys 
                85                  90                  95      


Ala Met Ser Lys Gly Gly Ser Phe Lys Thr Ser Leu Tyr Tyr Gly Tyr 
            100                 105                 110         


Lys Tyr Glu Gln Ser Ser Ala Asn Gly Ile Gln Asn Lys Glu Ile Ile 
        115                 120                 125             


Thr Lys Ile Glu Ser Ile Asn Gly Ala Glu His Ile Ala Phe Leu Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asn Gly Val Gly Gly Asp Lys Thr Ala Glu Tyr Ala 
145                 150                 155                 160 


Ile Pro Leu Glu Val Leu Lys Lys Asn Leu Lys 
                165                 170     


<210>  31
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  31

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Gly Glu Gln Ser Ser 
1               5                   10                  15      


Gly Glu Ile Asn His Thr Leu Tyr Asp Glu Gln Ser Asn Gly Asp Leu 
            20                  25                  30          


Lys Leu Lys Lys Ile Glu Phe Ser Lys Phe Thr Val Lys Ile Lys Asn 
        35                  40                  45              


Lys Asp Asn Asn Ser Asn Trp Thr Asp Leu Gly Asp Leu Val Val Arg 
    50                  55                  60                  


Lys Glu Glu Asn Gly Ile Asp Thr Ser Leu Asn Ala Gly Gly His Ser 
65                  70                  75                  80  


Ala Thr Phe Phe Ser Leu Lys Glu Ser Glu Val Asn Asn Phe Ile Lys 
                85                  90                  95      


Ala Met Thr Lys Gly Gly Ser Phe Lys Thr Ser Leu Tyr Tyr Gly Tyr 
            100                 105                 110         


Lys Tyr Glu Gln Ser Ser Ala Asn Gly Ile Gln Asn Lys Glu Ile Ile 
        115                 120                 125             


Thr Lys Ile Glu Ser Ile Asn Gly Ala Glu His Ile Ala Phe Leu Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asn Ser Val Gly Gly Asp Lys Thr Ala Glu Tyr Ala 
145                 150                 155                 160 


Ile Pro Leu Glu Val Leu Lys Lys Asn Leu Lys 
                165                 170     


<210>  32
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  32

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ile Ser 
1               5                   10                  15      


Gly Glu Ile Asn Arg Thr Leu Tyr Asp Glu Gln Ser Asn Gly Glu Leu 
            20                  25                  30          


Lys Leu Lys Lys Ile Glu Phe Ser Lys Phe Thr Val Lys Ile Lys Asn 
        35                  40                  45              


Lys Asp Asn Asn Ser Asn Trp Thr Asp Leu Gly Asp Leu Val Val Arg 
    50                  55                  60                  


Lys Glu Glu Asn Gly Ile Asp Thr Gly Leu Asn Ala Gly Gly His Ser 
65                  70                  75                  80  


Ala Thr Phe Phe Ser Leu Thr Glu Ser Glu Val Asn Asn Phe Ile Lys 
                85                  90                  95      


Thr Met Thr Lys Gly Gly Ser Phe Lys Thr Ser Leu Tyr Phe Gly Tyr 
            100                 105                 110         


Lys Tyr Glu Gln Ser Ser Ala Asn Gly Ile Gln Asn Lys Glu Ile Ile 
        115                 120                 125             


Thr Lys Ile Glu Ser Ile Asn Gly Ala Glu His Ile Ala Phe Leu Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asn Gly Val Gly Gly Asp Lys Thr Ala Glu Tyr Ala 
145                 150                 155                 160 


Ile Pro Ile Glu Val Leu Lys Lys Asn Leu Lys 
                165                 170     


<210>  33
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  33

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Gly Glu Gln Ser Ser 
1               5                   10                  15      


Gly Glu Ile Asn His Thr Leu Tyr Asp Glu Gln Ser Asn Gly Glu Leu 
            20                  25                  30          


Lys Leu Lys Lys Ile Glu Phe Ser Lys Ile Thr Val Lys Ile Lys Asn 
        35                  40                  45              


Lys Asp Lys Asn Ser Asn Trp Thr Asp Leu Gly Asp Leu Val Val Arg 
    50                  55                  60                  


Lys Glu Glu Asn Gly Ile Asp Thr Gly Leu Asn Ala Gly Gly His Ser 
65                  70                  75                  80  


Val Thr Phe Phe Ser Leu Lys Glu Ser Gly Val Asn Asn Phe Ile Lys 
                85                  90                  95      


Ala Met Thr Lys Gly Gly Ser Phe Lys Thr Ser Leu Tyr Tyr Gly Tyr 
            100                 105                 110         


Lys Tyr Glu Gln Ser Ser Ala Asn Gly Ile Gln Asn Lys Glu Ile Ile 
        115                 120                 125             


Thr Lys Ile Glu Ser Ile Asn Gly Ala Glu His Ile Ala Phe Leu Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asn Gly Val Gly Gly Asp Lys Thr Ala Glu Tyr Ala 
145                 150                 155                 160 


Val Pro Leu Glu Val Leu Lys Lys Asn Leu Lys 
                165                 170     


<210>  34
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  34

Leu Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Ser 
1               5                   10                  15      


Gly Glu Ile Asn His Thr Leu Tyr Asp Glu Gln Ser Asn Gly Glu Leu 
            20                  25                  30          


Lys Leu Lys Lys Ile Glu Phe Ser Lys Phe Thr Val Lys Ile Lys Asn 
        35                  40                  45              


Lys Thr Val Asn Ser Asn Trp Thr Asp Leu Gly Asp Leu Val Val Arg 
    50                  55                  60                  


Lys Glu Glu Asn Gly Ile Asp Thr Gly Leu Asn Ala Gly Gly His Ser 
65                  70                  75                  80  


Ala Thr Phe Phe Ser Leu Lys Glu Ser Glu Val Asn Asn Phe Ile Lys 
                85                  90                  95      


Ala Met Thr Lys Gly Gly Ser Phe Lys Thr Ser Leu Tyr Tyr Gly Tyr 
            100                 105                 110         


Lys Tyr Glu Gln Ser Ser Ala Asn Gly Ile Gln Asn Lys Glu Ile Ile 
        115                 120                 125             


Thr Lys Ile Glu Ser Ile Asn Gly Ala Glu His Ile Ala Phe Leu Gly 
    130                 135                 140                 


Val Asn Ile Asn Asn Gly Val Gly Gly Asp Lys Thr Ala Glu Tyr Ala 
145                 150                 155                 160 


Ile Pro Leu Glu Val Leu Lys Lys Asn Leu Lys 
                165                 170     


<210>  35
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OspE mutant

<400>  35

Ser Ile Gly Ala Cys Lys Ile His Thr Ser Tyr Asp Glu Gln Ser Ser 
1               5                   10                  15      


Gly Glu Ile Asn His Thr Leu Tyr Asp Glu Gln Ser Asn Gly Glu Leu 
            20                  25                  30          


Lys Leu Lys Lys Ile Glu Phe Ser Lys Phe Thr Val Lys Ile Lys Asn 
        35                  40                  45              


Lys Asp Asn Asn Ser Asn Trp Thr Asp Leu Gly Asp Leu Val Val Arg 
    50                  55                  60                  


Lys Glu Glu Asn Gly Ile Asp Thr Gly Leu Asn Ala Gly Gly His Ser 
65                  70                  75                  80  


Ala Thr Phe Phe Ser Leu Lys Glu Ser Glu Val Asn Asn Phe Ile Lys 
                85                  90                  95      


Ala Met Thr Lys Gly Gly Ser Phe Lys Thr Ser Leu Tyr Tyr Gly Tyr 
            100                 105                 110         


Lys Tyr Glu Gln Ser Ser Ala Asn Gly Ile Gln Asn Lys Glu Ile Ile 
        115                 120                 125             


Thr Lys Ile Glu Ser Ile Asn Gly Ala Glu His Ile Ala Phe Leu Gly 
    130                 135                 140                 


Asp Lys Leu Asn Thr Val Trp Gly Lys Ile Lys Gln Leu Asn Met Gln 
145                 150                 155                 160 


Tyr His 
        


<210>  36
<211>  210
<212>  PRT
<213>  Borrelia burgdorferi

<400>  36

Met Lys Lys Asn Thr Leu Ser Ala Ile Leu Met Thr Leu Phe Leu Phe 
1               5                   10                  15      


Ile Ser Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 
            20                  25                  30          


Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 
        35                  40                  45              


Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 
    50                  55                  60                  


Leu Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 
65                  70                  75                  80  


Ile His Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn His Asn Gly Ser 
                85                  90                  95      


Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln Lys Leu 
            100                 105                 110         


Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile Asp Ala Ala Lys 
        115                 120                 125             


Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu Lys Glu Lys His Thr Asp 
    130                 135                 140                 


Leu Gly Lys Glu Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 
145                 150                 155                 160 


Lys Thr Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 
                165                 170                 175     


Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala 
            180                 185                 190         


Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Lys 
        195                 200                 205             


Lys Pro 
    210 


