                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Multiple-Variable IL-2 Dose Regimen For Treating Immune Disorders

<130>  DFS-143.25

<140>  PCT/US2015/054466
<141>  2015-10-07

<150>  62/061,952
<151>  2014-10-09

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  1
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactt ga                         462


<210>  2
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  3
<211>  462
<212>  DNA
<213>  Pan troglodytes

<400>  3
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactt ga                         462


<210>  4
<211>  153
<212>  PRT
<213>  Pan troglodytes

<400>  4

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  5
<211>  465
<212>  DNA
<213>  Macaca mulatta

<400>  5
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaattga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agagatacca aggacttaat cagcaatatc aacgtaatag ttctggaact aaagggatct      360

gaaacaacac tgatgtgtga atatgctgat gagacagcaa ccattgtaga atttctgaac      420

agatggatta ccttttgtca aagcatcatc tcaacactga cctga                      465


<210>  6
<211>  154
<212>  PRT
<213>  Macaca mulatta

<400>  6

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Asp Thr Lys Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Leu Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150                 


<210>  7
<211>  468
<212>  DNA
<213>  Canis familiaris

<400>  7
atgtacaaaa tgcaactctt gtcttgcatc gcactgacgc ttgtacttgt cgcaaacagt       60

gcacctatta cttcaagctc tacaaaggaa acagagcaac agatggagca attactgctg      120

gatttacagt tgcttttgaa tggagttaat aattatgaga acccccaact ctccaggatg      180

ctcacattta agttttacac gcccaagaag gccacagaat ttacacacct tcaatgtcta      240

gcagaagaac tcaaaaacct ggaggaagtg ctaggtttac ctcaaagcaa aaacgttcac      300

ttgacagaca ccaaggaatt aatcagcaat atgaatgtaa cacttctgaa actaaaggga      360

tctgaaacaa gttacaactg tgaatatgat gacgagacag caaccattac agaatttctg      420

aacaaatgga ttaccttttg tcaaagcatc ttctcaacac tgacttga                   468


<210>  8
<211>  155
<212>  PRT
<213>  Canis familiaris

<400>  8

Met Tyr Lys Met Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Val Leu 
1               5                   10                  15      


Val Ala Asn Ser Ala Pro Ile Thr Ser Ser Ser Thr Lys Glu Thr Glu 
            20                  25                  30          


Gln Gln Met Glu Gln Leu Leu Leu Asp Leu Gln Leu Leu Leu Asn Gly 
        35                  40                  45              


Val Asn Asn Tyr Glu Asn Pro Gln Leu Ser Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Thr Pro Lys Lys Ala Thr Glu Phe Thr His Leu Gln Cys Leu 
65                  70                  75                  80  


Ala Glu Glu Leu Lys Asn Leu Glu Glu Val Leu Gly Leu Pro Gln Ser 
                85                  90                  95      


Lys Asn Val His Leu Thr Asp Thr Lys Glu Leu Ile Ser Asn Met Asn 
            100                 105                 110         


Val Thr Leu Leu Lys Leu Lys Gly Ser Glu Thr Ser Tyr Asn Cys Glu 
        115                 120                 125             


Tyr Asp Asp Glu Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys Trp Ile 
    130                 135                 140                 


Thr Phe Cys Gln Ser Ile Phe Ser Thr Leu Thr 
145                 150                 155 


<210>  9
<211>  510
<212>  DNA
<213>  Mus musculus

<400>  9
atgtacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc       60

gcacccactt caagctccac ttcaagctct acagcggaag cacagcagca gcagcagcag      120

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc      180

aggatggaga attacaggaa cctgaaactc cccaggatgc tcaccttcaa attttacttg      240

cccaagcagg ccacagaatt gaaagatctt cagtgcctag aagatgaact tggacctctg      300

cggcatgttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      360

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      420

caattcgatg atgagtcagc aactgtggtg gactttctga ggagatggat agccttctgt      480

caaagcatca tctcaacaag ccctcaataa                                       510


<210>  10
<211>  169
<212>  PRT
<213>  Mus musculus

<400>  10

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210>  11
<211>  468
<212>  DNA
<213>  Rattus norvegicus

<400>  11
atgtacagca tgcagctcgc atcctgtgtt gcactgacgc ttgtcctcct tgtcaacagc       60

gcacccactt caagccctgc aaaggaaaca cagcagcacc tggagcagct gttgctggac      120

ttacaggtgc tcctgagagg gatcgataat tacaagaatc tgaaactccc catgatgctc      180

acgtttaaat tttacttgcc caagcaggcc acagaattga aacatcttca gtgcctggaa      240

aatgaactcg gagctctgca gcgtgtgttg gatttgactc aaagcaaaag ctttcacttg      300

gaagacgctg gaaatttcat cagcaatatc agagtaactg ttgtaaaact aaagggctct      360

gaaaacaaat ttgagtgcca attcgatgat gagccagcaa ctgtggtgga atttctgagg      420

agatggatag ccatctgtca aagcatcatc tcaacaatga ctcagtaa                   468


<210>  12
<211>  155
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Ala Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Pro Ala Lys Glu Thr Gln Gln 
            20                  25                  30          


His Leu Glu Gln Leu Leu Leu Asp Leu Gln Val Leu Leu Arg Gly Ile 
        35                  40                  45              


Asp Asn Tyr Lys Asn Leu Lys Leu Pro Met Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Asn Glu Leu Gly Ala Leu Gln Arg Val Leu Asp Leu Thr Gln Ser Lys 
                85                  90                  95      


Ser Phe His Leu Glu Asp Ala Gly Asn Phe Ile Ser Asn Ile Arg Val 
            100                 105                 110         


Thr Val Val Lys Leu Lys Gly Ser Glu Asn Lys Phe Glu Cys Gln Phe 
        115                 120                 125             


Asp Asp Glu Pro Ala Thr Val Val Glu Phe Leu Arg Arg Trp Ile Ala 
    130                 135                 140                 


Ile Cys Gln Ser Ile Ile Ser Thr Met Thr Gln 
145                 150                 155