                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  STABLE GLP-1 BASED GLP-1/GLUCAGON RECEPTOR CO-AGONISTS

<130>  140051WO01

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  HOMO SAPIENS

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Ala, Aib, Acb, or Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Val, Leu, Ile, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Gly, Ala, Glu, Lys, Arg, Ser, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Gln, Arg, or Lys

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituent covalently attached

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Val, Leu, or Ile

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Gly, Thr, Lys, or is absent

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Ala, Gly, Lys, Ser, or is absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Gly or is absent

<400>  2

His Xaa His Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Glu Xaa 
1               5                   10                  15      


Xaa Ala Ala Xaa Xaa Phe Ile Ala Trp Leu Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  3
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Substituent covalently attached

<400>  3

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Lys 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Substituent covalently attached

<400>  4

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Lys 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  5

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  6

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  misc
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  misc
<222>  (2)..(2)
<223>  Aib

<220>
<221>  misc
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  7

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  8

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  9

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  10

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  11

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  12

His Ala His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Gly 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  13
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  13

His Ala His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Gly 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Gly Gly Gly 
            20                  25                  30      


<210>  14
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  14

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  15
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Substituent covalently attached

<400>  15

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Gly Gly Gly 
            20                  25                  30      


<210>  16
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  16

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Gly Lys Gly 
            20                  25                  30      


<210>  17
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Substituent covalently attached

<400>  17

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Gly 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Substituent covalently attached

<400>  18

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gly 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  19
<211>  28
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  19

His Ala His Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Gly 
1               5                   10                  15      


Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Lys 
            20                  25              


<210>  20
<211>  28
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Substituent covalently attached

<400>  20

His Ala His Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Leu Arg 
            20                  25              


<210>  21
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Substituent covalently attached

<400>  21

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Leu Lys Arg 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  22

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Gly 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Substituent covalently attached

<400>  23

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Lys 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Substituent covalently attached

<400>  24

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Arg Lys 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Substituent covalently attached

<400>  25

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Arg 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Lys 
            20                  25                  


<210>  26
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Substituent covalently attached

<400>  26

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Arg 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Lys 
            20                  25                  


<210>  27
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  27

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  28
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Substituent covalently attached

<400>  28

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gly 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Lys 
            20                  25                  


<210>  29
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  29

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  30
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Substituent covalently attached

<400>  30

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Glu Gly 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Arg Lys 
            20                  25                  


<210>  31
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  31

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  32
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  32

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  33
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  33

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Ala 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Gly Gly Gly 
            20                  25                  30      


<210>  34
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Substituent covalently attached

<400>  34

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Lys 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Substituent covalently attached

<400>  35

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  36
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  36

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Ala 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  37
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  37

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Gly 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Gly Ala Gly 
            20                  25                  30      


<210>  38
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  38

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Gly 
1               5                   10                  15      


Arg Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Gly Ser Gly 
            20                  25                  30      


<210>  39
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  39

His Gly His Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  40
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  40

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  41

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  42

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  43
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  43

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Leu Lys Thr 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Artifical sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  This amino acid residue is Imp (i.e. desaminohistidine)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Substituent covalently attached

<400>  44

His Xaa His Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Ile Lys Thr 
            20                  25                  


