SEQUENCE LISTING


<110> CELLECTIS
 
<120> METHOD FOR MODULATING CAR-INDUCED IMMUNE CELLS ACTIVITY

<130> P81405891PCT00

<150> PA201470623
<151> 2014-10-07

<160>112   

<170>  PatentIn version 3.5


<210>  1

<211>  25
<212>  PRT
<213>  homo sapiens

<220>
<223>  Signal sequence FcER1-SP

<400>  1
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala 
            20                  25  


<210>  2

<211>  273
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scFv

<400>  2
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Gln Ile Gln Leu Val Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
    50                  55                  60                  


Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr 
65                  70                  75                  80  


Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser 
                85                  90                  95      


Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys 
            100                 105                 110         


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp 
        115                 120                 125             


Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn 
            180                 185                 190         


Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
                245                 250                 255     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro 
    


<210>  3

<211>  283
<212>  PRT
<213>  artificial sequence

<220>
<223>  Klo43-3-scFv

<400>  3
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Lys Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala 
        35                  40                  45              


Ala Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln 
    50                  55                  60                  


Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala 
65                  70                  75                  80  


Asp Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr 
                85                  90                  95      


Leu Ser Arg Asp Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala 
            100                 105                 110         


Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala 
        115                 120                 125             


Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met 
                165                 170                 175     


Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn 
            180                 185                 190         


Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr 
        195                 200                 205             


Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser 
    210                 215                 220                 


Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly 
225                 230                 235                 240 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
                245                 250                 255     


Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly 
            260                 265                 270         


Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Pro 
        275                 280             


<210>  4

<211>  271
<212>  PRT
<213>  artificial sequence

<220>
<223>  5T4WT19-scFv

<400>  4
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Asp Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His Trp Val Lys Gln 
    50                  55                  60                  


Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile Asn Pro Asn Asn 
65                  70                  75                  80  


Gly Val Thr Leu Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
                85                  90                  95      


Val Asp Lys Ser Ser Thr Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Met Ile Thr 
        115                 120                 125             


Asn Tyr Val Met Asp Tyr Trp Gly Gln Val Thr Ser Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ser Ile Val Met Thr Gln Thr Pro Thr Phe Leu Leu Val Ser Ala Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Thr Leu Leu Ile 
        195                 200                 205             


Ser Tyr Thr Ser Ser Arg Tyr Ala Gly Val Pro Asp Arg Phe Ile Gly 
    210                 215                 220                 


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Leu Gln Ala 
225                 230                 235                 240 


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asn Ser Pro Pro 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Pro 
            260                 265                 270     


<210>  5

<211>  277
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH-4G7-scFv

<400>  5
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro 
        275         


<210>  6

<211>  45
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD8A hinge

<400>  6
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  7

<211>  233
<212>  PRT
<213>  homo sapiens

<220>
<223>  IGHG1 hinge

<400>  7
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230             


<210>  8

<211>  101
<212>  PRT
<213>  homo sapiens

<220>
<223>  EpoR_D2 hinge

<400>  8
Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly His Val 
1               5                   10                  15      


Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser His Ile 
            20                  25                  30          


Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser Val Gln 
        35                  40                  45              


Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser Asn Leu 
    50                  55                  60                  


Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met Ala Glu 
65                  70                  75                  80  


Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val Ser Leu 
                85                  90                  95      


Leu Thr Pro Ser Asp 
            100     


<210>  9

<211>  53
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alpha-TI-A TM domain

<400>  9
Ile Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly 
1               5                   10                  15      


Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys 
            20                  25                  30          


Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn 
        35                  40                  45              


Pro Lys Asn Asn Arg 
    50              


<210>  10

<211>  98
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alpha-TI-B TM domain

<400>  10
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe Ile 
        35                  40                  45              


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    50                  55                  60                  


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
65                  70                  75                  80  


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                85                  90                  95      


Asn Arg 
        


<210>  11

<211>  373
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD19 alpha chain

<400>  11
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ala Asp Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Phe Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr 
                325                 330                 335     


Gly Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile 
            340                 345                 350         


Lys Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro 
        355                 360                 365             


Asn Pro Lys Asn Asn 
    370             


<210>  12

<211>  257
<212>  PRT
<213>  artificial sequence

<220>
<223>  beta-41BB chain

<400>  12
Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu 
    


<210>  13

<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Sequence signal Gamma

<400>  13
Met Ala Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln 
1               5                   10                  15      


Ala Ala Ala Gly 
            20  


<210>  14

<211>  114
<212>  PRT
<213>  homo sapiens

<220>
<223>  FKBP

<400>  14
Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
1               5                   10                  15      


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
            20                  25                  30          


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
        35                  40                  45              


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
    50                  55                  60                  


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
65                  70                  75                  80  


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
                85                  90                  95      


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly 
            100                 105                 110         


Ala Pro 
        


<210>  15

<211>  102
<212>  PRT
<213>  homo sapiens

<220>
<223>  FRB

<400>  15
Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly 
1               5                   10                  15      


Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly 
            20                  25                  30          


Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro 
        35                  40                  45              


Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu 
    50                  55                  60                  


Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val 
65                  70                  75                  80  


Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg 
                85                  90                  95      


Ile Gly Ser Gly Ala Pro 
            100         


<210>  16

<211>  156
<212>  PRT
<213>  artificial sequence

<220>
<223>  Gamma-TI-A

<400>  16
Ile Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu 
1               5                   10                  15      


Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val 
            20                  25                  30          


Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Arg Val Lys Phe Ser 
        35                  40                  45              


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
    50                  55                  60                  


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
65                  70                  75                  80  


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                85                  90                  95      


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            100                 105                 110         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        115                 120                 125             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    130                 135                 140                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
145                 150                 155     


<210>  17

<211>  156
<212>  PRT
<213>  artificial sequence

<220>
<223>  Gamma-TI-B

<400>  17
Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu 
1               5                   10                  15      


Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val 
            20                  25                  30          


Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Arg Val Lys Phe Ser 
        35                  40                  45              


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
    50                  55                  60                  


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
65                  70                  75                  80  


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                85                  90                  95      


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            100                 105                 110         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        115                 120                 125             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    130                 135                 140                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
145                 150                 155     


<210>  18

<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH-4G7-ss

<400>  18
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly 
            20          


<210>  19

<211>  25
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD8a TM

<400>  19
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Arg 
            20                  25  


<210>  20

<211>  31
<212>  PRT
<213>  homo sapiens

<220>
<223>  4-1BB TM

<400>  20
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg 
            20                  25                  30      


<210>  21

<211>  27
<212>  PRT
<213>  homo sapiens

<220>
<223>  DAP10 TM

<400>  21
Ile Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu 
1               5                   10                  15      


Ile Val Gly Ala Val Phe Leu Cys Ala Arg Arg 
            20                  25          


<210>  22

<211>  33
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD28 TM

<400>  22
Ile Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
            20                  25                  30          


Arg 
    


<210>  23

<211>  97
<212>  PRT
<213>  homo sapiens

<220>
<223>  PD1 inhibitory signaling domain

<400>  23
Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
1               5                   10                  15      


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
            20                  25                  30          


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
        35                  40                  45              


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
    50                  55                  60                  


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
65                  70                  75                  80  


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
                85                  90                  95      


Glu 
    


<210>  24

<211>  110
<212>  PRT
<213>  homo sapiens

<220>
<223>  FKBP_pos3_IMP

<400>  24
Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
1               5                   10                  15      


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
            20                  25                  30          


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
        35                  40                  45              


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
    50                  55                  60                  


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
65                  70                  75                  80  


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
                85                  90                  95      


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Glu 
            100                 105                 110 


<210>  25

<211>  98
<212>  PRT
<213>  homo sapiens

<220>
<223>  FRB_pos3_IMP

<400>  25
Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly 
1               5                   10                  15      


Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly 
            20                  25                  30          


Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro 
        35                  40                  45              


Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu 
    50                  55                  60                  


Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val 
65                  70                  75                  80  


Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg 
                85                  90                  95      


Ile Glu 
        


<210>  26

<211>  45
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD28 linker

<400>  26
Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
1               5                   10                  15      


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            20                  25                  30          


Ala Ala Tyr Arg Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        35                  40                  45  


<210>  27

<211>  48
<212>  PRT
<213>  homo sapiens

<220>
<223>  4-1BB  linker

<400>  27
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
1               5                   10                  15      


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            20                  25                  30          


Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser 
        35                  40                  45              






<210>  28

<211>  50
<212>  PRT
<213>  homo sapiens

<220>
<223>  OX40 linker

<400>  28
Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile Gly Ser Gly Ser Gly Ser 
        35                  40                  45              


Gly Ser 
    50  


<210>  29

<211>  28
<212>  PRT
<213>  homo sapiens

<220>
<223>  DAP10 linker

<400>  29
Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25              


<210>  30

<211>  54
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD18 linker

<400>  30
Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg Arg Phe Glu 
1               5                   10                  15      


Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro Leu Phe Lys 
            20                  25                  30          


Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu Ser Gly Ser 
        35                  40                  45              


Gly Ser Gly Ser Gly Ser 
    50                  


<210>  31

<211>  49
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD28 linker

<400>  31
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Ser 
    


<210>  32

<211>  33
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD275 linker

<400>  32
Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly Ala Trp Ala Val Ser 
1               5                   10                  15      


Pro Glu Thr Glu Leu Thr Gly His Val Gly Ser Gly Ser Gly Ser Gly 
            20                  25                  30          


Ser 
    


<210>  33

<211>  68
<212>  PRT
<213>  homo sapiens

<220>
<223>  HVEM linker

<400>  33
Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Gly Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser 
65              


<210>  34

<211>  45
<212>  PRT
<213>  homo sapiens

<220>
<223>  LIGHT linker

<400>  34
Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Gly Ser Gly Ser Gly Ser Gly Ser 
        35                  40                  45  


<210>  35

<211>  30
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD40L linker

<400>  35
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25                  30  


<210>  36

<211>  66
<212>  PRT
<213>  homo sapiens

<220>
<223>  GITR linker

<400>  36
Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val Gly Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Ser 
65      


<210>  37

<211>  56
<212>  PRT
<213>  homo sapiens

<220>
<223>  TIM1 linker

<400>  37
Lys Lys Tyr Phe Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe 
1               5                   10                  15      


Ser Ser Leu Gln Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val 
            20                  25                  30          


Gln Ala Glu Asp Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        35                  40                  45              


Gly Ser Gly Ser Gly Ser Gly Ser 
    50                  55      


<210>  38

<211>  85
<212>  PRT
<213>  homo sapiens

<220>
<223>  SLAM linker

<400>  38
Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr Val Glu 
1               5                   10                  15      


Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly Pro Leu 
            20                  25                  30          


Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr Thr Ile 
        35                  40                  45              


Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu Thr Asn 
    50                  55                  60                  


Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser Gly Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Ser 
                85  


<210>  39

<211>  124
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD2 linker

<400>  39
Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser Asn Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 


<210>  40

<211>  40
<212>  PRT
<213>  homo sapiens

<220>
<223>  TLT-2 linker

<400>  40
Lys Lys Arg His Met Ala Ser Tyr Ser Met Cys Ser Asp Pro Ser Thr 
1               5                   10                  15      


Arg Asp Pro Pro Gly Arg Pro Glu Pro Tyr Val Glu Val Tyr Leu Ile 
            20                  25                  30          


Gly Ser Gly Ser Gly Ser Gly Ser 
        35                  40  


<210>  41

<211>  62
<212>  PRT
<213>  homo sapiens

<220>
<223>  LAG3 linker

<400>  41
His Leu Trp Arg Arg Gln Trp Arg Pro Arg Arg Phe Ser Ala Leu Glu 
1               5                   10                  15      


Gln Gly Ile His Pro Pro Gln Ala Gln Ser Lys Ile Glu Glu Leu Glu 
            20                  25                  30          


Gln Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
        35                  40                  45              


Pro Glu Pro Glu Gln Leu Gly Ser Gly Ser Gly Ser Gly Ser 
    50                  55                  60          


<210>  42

<211>  60
<212>  PRT
<213>  homo sapiens

<220>
<223>  DAP12 linker

<400>  42
Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys Gly Ser Gly Ser Gly Ser Gly Ser 
    50                  55                  60  


<210>  43

<211>  107
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD84 linker

<400>  43
Arg Leu Phe Lys Arg Arg Gln Gly Arg Ile Phe Pro Glu Gly Ser Cys 
1               5                   10                  15      


Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala Ala Ser Lys Lys Thr Ile 
            20                  25                  30          


Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln Pro Ala Glu Ser Arg 
        35                  40                  45              


Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu Pro Ser Lys Glu Glu 
    50                  55                  60                  


Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe Ala Asp Lys Met Gly 
65                  70                  75                  80  


Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly Thr Ser Ser Tyr Glu 
                85                  90                  95      


Ile Val Ile Gly Ser Gly Ser Gly Ser Gly Ser 
            100                 105         


<210>  44

<211>  113
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD244 linker

<400>  44
Glu Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg 
1               5                   10                  15      


Asn His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala 
        35                  40                  45              


Tyr Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg 
    50                  55                  60                  


Lys Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile 
65                  70                  75                  80  


Gly Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys 
                85                  90                  95      


Glu Leu Glu Asn Phe Asp Val Tyr Ser Gly Ser Gly Ser Gly Ser Gly 
            100                 105                 110         


Ser 
    


<210>  45

<211>  157
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD229 linker

<400>  45
Leu Tyr Ser Val Leu Ser Gln Gly Tyr Glu Lys Leu Asp Thr Pro Leu 
1               5                   10                  15      


Arg Pro Ala Arg Gln Gln Pro Thr Pro Thr Ser Asp Ser Ser Ser Asp 
            20                  25                  30          


Ser Asn Leu Thr Thr Glu Glu Asp Glu Asp Arg Pro Glu Val His Lys 
        35                  40                  45              


Pro Ile Ser Gly Arg Tyr Glu Val Phe Asp Gln Val Thr Gln Glu Gly 
    50                  55                  60                  


Ala Gly His Asp Pro Ala Pro Glu Gly Gln Ala Asp Tyr Asp Pro Val 
65                  70                  75                  80  


Thr Pro Tyr Val Thr Glu Val Glu Ser Val Val Gly Glu Asn Thr Met 
                85                  90                  95      


Tyr Ala Gln Val Phe Asn Leu Gln Gly Lys Thr Pro Val Ser Gln Lys 
            100                 105                 110         


Glu Glu Ser Ser Ala Thr Ile Tyr Cys Ser Ile Arg Lys Pro Gln Val 
        115                 120                 125             


Val Pro Pro Pro Gln Gln Asn Asp Leu Glu Ile Pro Glu Ser Pro Thr 
    130                 135                 140                 


Tyr Glu Asn Phe Thr Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155         


<210>  46

<211>  151
<212>  PRT
<213>  homo sapiens

<220>
<223>  LTBR linker

<400>  46
Lys Ala His Pro Tyr Phe Pro Asp Leu Val Gln Pro Leu Leu Pro Ile 
1               5                   10                  15      


Ser Gly Asp Val Ser Pro Val Ser Thr Gly Leu Pro Ala Ala Pro Val 
            20                  25                  30          


Leu Glu Ala Gly Val Pro Gln Gln Gln Ser Pro Leu Asp Leu Thr Arg 
        35                  40                  45              


Glu Pro Gln Leu Glu Pro Gly Glu Gln Ser Gln Val Ala His Gly Thr 
    50                  55                  60                  


Asn Gly Ile His Val Thr Gly Gly Ser Met Thr Ile Thr Gly Asn Ile 
65                  70                  75                  80  


Tyr Ile Tyr Asn Gly Pro Val Leu Gly Gly Pro Pro Gly Pro Gly Asp 
                85                  90                  95      


Leu Pro Ala Thr Pro Glu Pro Pro Tyr Pro Ile Pro Glu Glu Gly Asp 
            100                 105                 110         


Pro Gly Pro Pro Gly Leu Ser Thr Pro His Gln Glu Asp Gly Lys Ala 
        115                 120                 125             


Trp His Leu Ala Glu Thr Glu His Cys Gly Ala Thr Pro Ser Asn Gly 
    130                 135                 140                 


Ser Gly Ser Gly Ser Gly Ser 
145                 150     


<210>  47

<211>  110
<212>  PRT
<213>  homo sapiens

<220>
<223>  FKBP_pos5-ter-alpha

<400>  47
Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
1               5                   10                  15      


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
            20                  25                  30          


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
        35                  40                  45              


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
    50                  55                  60                  


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
65                  70                  75                  80  


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
                85                  90                  95      


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Glu 
            100                 105                 110 


<210>  48

<211>  98
<212>  PRT
<213>  homo sapiens

<220>
<223>  FRB_pos5-ter-alpha

<400>  48
Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly 
1               5                   10                  15      


Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly 
            20                  25                  30          


Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro 
        35                  40                  45              


Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu 
    50                  55                  60                  


Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val 
65                  70                  75                  80  


Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg 
                85                  90                  95      


Ile Glu 
        


<210>  49

<211>  173
<212>  PRT
<213>  artificial sequence

<220>
<223>  gamma-CD3z chain

<400>  49
Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Arg Val Lys 
    50                  55                  60                  


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
65                  70                  75                  80  


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                85                  90                  95      


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            100                 105                 110         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        115                 120                 125             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    130                 135                 140                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
145                 150                 155                 160 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                165                 170             


<210>  50

<211>  101
<212>  PRT
<213>  homo sapiens

<220>
<223>  PD1_pos3

<400>  50
Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
1               5                   10                  15      


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
            20                  25                  30          


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
        35                  40                  45              


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
    50                  55                  60                  


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
65                  70                  75                  80  


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
                85                  90                  95      


Gly Ser Gly Ser Ser 
            100     


<210>  51

<211>  114
<212>  PRT
<213>  homo sapiens

<220>
<223>  FKBP_pos4-IMP

<400>  51
Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
1               5                   10                  15      


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
            20                  25                  30          


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
        35                  40                  45              


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
    50                  55                  60                  


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
65                  70                  75                  80  


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
                85                  90                  95      


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly 
            100                 105                 110         


Ser Gly 
        


<210>  52

<211>  102
<212>  PRT
<213>  homo sapiens

<220>
<223>  FRB_pos4-IMP

<400>  52
Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly 
1               5                   10                  15      


Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly 
            20                  25                  30          


Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro 
        35                  40                  45              


Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu 
    50                  55                  60                  


Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val 
65                  70                  75                  80  


Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg 
                85                  90                  95      


Ile Gly Ser Gly Ser Gly 
            100         


<210>  53

<211>  97
<212>  PRT
<213>  homo sapiens

<220>
<223>  PD1_pos5-ter

<400>  53
Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
1               5                   10                  15      


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
            20                  25                  30          


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
        35                  40                  45              


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
    50                  55                  60                  


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
65                  70                  75                  80  


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
                85                  90                  95      


Glu 
    


<210>  54

<211>  110
<212>  PRT
<213>  homo sapiens

<220>
<223>  FKBP_pos4-ter-IMP

<400>  54
Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
1               5                   10                  15      


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
            20                  25                  30          


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
        35                  40                  45              


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
    50                  55                  60                  


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
65                  70                  75                  80  


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
                85                  90                  95      


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Glu 
            100                 105                 110 


<210>  55

<211>  98
<212>  PRT
<213>  homo sapiens

<220>
<223>  FRB_pos4-ter-IMP

<400>  55
Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly 
1               5                   10                  15      


Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly 
            20                  25                  30          


Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro 
        35                  40                  45              


Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu 
    50                  55                  60                  


Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val 
65                  70                  75                  80  


Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg 
                85                  90                  95      


Ile Glu 
        


<210>  56

<211>  101
<212>  PRT
<213>  homo sapiens

<220>
<223>  PD1_pos4

<400>  56
Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
1               5                   10                  15      


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
            20                  25                  30          


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
        35                  40                  45              


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
    50                  55                  60                  


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
65                  70                  75                  80  


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
                85                  90                  95      


Gly Ser Gly Ser Gly 
            100     


<210>  57

<211>  108
<212>  PRT
<213>  homo sapiens

<220>
<223>  FKBP_pos5-ter-IMP

<400>  57
Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Glu 
            100                 105             


<210>  58

<211>  96
<212>  PRT
<213>  homo sapiens

<220>
<223>  FRB_pos5-ter-IMP

<400>  58
Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Glu 
                85                  90                  95      






<210>  59

<211>  344
<212>  PRT
<213>  homo sapiens

<220>
<223>  IR-10RA inhibitory domain

<400>  59
Ile Val Ile Ile Phe Phe Ala Phe Val Leu Leu Leu Ser Gly Ala Leu 
1               5                   10                  15      


Ala Tyr Cys Leu Ala Leu Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu 
            20                  25                  30          


Pro Ser Val Leu Leu Phe Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser 
        35                  40                  45              


Gln Arg Pro Ser Pro Glu Thr Gln Asp Thr Ile His Pro Leu Asp Glu 
    50                  55                  60                  


Glu Ala Phe Leu Lys Val Ser Pro Glu Leu Lys Asn Leu Asp Leu His 
65                  70                  75                  80  


Gly Ser Thr Asp Ser Gly Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr 
                85                  90                  95      


Glu Glu Pro Gln Phe Leu Leu Pro Asp Pro His Pro Gln Ala Asp Arg 
            100                 105                 110         


Thr Leu Gly Asn Arg Glu Pro Pro Val Leu Gly Asp Ser Cys Ser Ser 
        115                 120                 125             


Gly Ser Ser Asn Ser Thr Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser 
    130                 135                 140                 


Leu Ser Pro Ser Thr Gly Pro Thr Trp Glu Gln Gln Val Gly Ser Asn 
145                 150                 155                 160 


Ser Arg Gly Gln Asp Asp Ser Gly Ile Asp Leu Val Gln Asn Ser Glu 
                165                 170                 175     


Gly Arg Ala Gly Asp Thr Gln Gly Gly Ser Ala Leu Gly His His Ser 
            180                 185                 190         


Pro Pro Glu Pro Glu Val Pro Gly Glu Glu Asp Pro Ala Ala Val Ala 
        195                 200                 205             


Phe Gln Gly Tyr Leu Arg Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr 
    210                 215                 220                 


Lys Thr Gly Cys Leu Glu Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly 
225                 230                 235                 240 


Pro Lys Phe Gly Arg Cys Leu Val Asp Glu Ala Gly Leu His Pro Pro 
                245                 250                 255     


Ala Leu Ala Lys Gly Tyr Leu Lys Gln Asp Pro Leu Glu Met Thr Leu 
            260                 265                 270         


Ala Ser Ser Gly Ala Pro Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu 
        275                 280                 285             


Trp Ser Leu Leu Ala Leu Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp 
    290                 295                 300                 


Trp Ser Phe Ala His Asp Leu Ala Pro Leu Gly Cys Val Ala Ala Pro 
305                 310                 315                 320 


Gly Gly Leu Leu Gly Ser Phe Asn Ser Asp Leu Val Thr Leu Pro Leu 
                325                 330                 335     


Ile Ser Ser Leu Gln Ser Ser Glu 
            340                 


<210>  60

<211>  107
<212>  PRT
<213>  homo sapiens

<220>
<223>  IR-10B inhibitory domain

<400>  60
Ile Trp Met Val Ala Val Ile Leu Met Ala Ser Val Phe Met Val Cys 
1               5                   10                  15      


Leu Ala Leu Leu Gly Cys Phe Ala Leu Leu Trp Cys Val Tyr Lys Lys 
            20                  25                  30          


Thr Lys Tyr Ala Phe Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys 
        35                  40                  45              


Glu Phe Leu Gly His Pro His His Asn Thr Leu Leu Phe Phe Ser Phe 
    50                  55                  60                  


Pro Leu Ser Asp Glu Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala 
65                  70                  75                  80  


Glu Asp Ser Glu Ser Gly Lys Gln Asn Pro Gly Asp Ser Cys Ser Leu 
                85                  90                  95      


Gly Thr Pro Pro Gly Gln Gly Pro Gln Ser Glu 
            100                 105         


<210>  61

<211>  303
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-exCID-n1

<400>  61
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
            20                  25                  30          


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
        35                  40                  45              


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
    50                  55                  60                  


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
65                  70                  75                  80  


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
                85                  90                  95      


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
            100                 105                 110         


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
        115                 120                 125             


Lys Leu Glu Gly Ser Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro 
    130                 135                 140                 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
145                 150                 155                 160 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
                165                 170                 175     


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            180                 185                 190         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Arg 
        195                 200                 205             


Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys 
    210                 215                 220                 


Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu 
225                 230                 235                 240 


Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val 
                245                 250                 255     


Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly 
            260                 265                 270         


Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala 
        275                 280                 285             


Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Glu 
    290                 295                 300             


<210>  62

<211>  485
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-exCID-n2

<400>  62
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His 
            20                  25                  30          


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
        35                  40                  45              


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
    50                  55                  60                  


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
65                  70                  75                  80  


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
                85                  90                  95      


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
            100                 105                 110         


Tyr His Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Glu Pro Lys Ser 
        115                 120                 125             


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Lys Lys Asp Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr 
        355                 360                 365             


Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
    370                 375                 380                 


Lys Arg Gly Arg Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg 
385                 390                 395                 400 


Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser 
                405                 410                 415     


Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu 
            420                 425                 430         


Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val 
        435                 440                 445             


Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala 
    450                 455                 460                 


Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys 
465                 470                 475                 480 


Ser Trp Pro Leu Glu 
                485 


<210>  63

<211>  361
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-exCID-n3

<400>  63
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
            20                  25                  30          


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
        35                  40                  45              


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
    50                  55                  60                  


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
65                  70                  75                  80  


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
                85                  90                  95      


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
            100                 105                 110         


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
        115                 120                 125             


Lys Leu Glu Gly Ser Gly Ala Pro Ala Pro Val Gly Leu Val Ala Arg 
    130                 135                 140                 


Leu Ala Asp Glu Ser Gly His Val Val Leu Arg Trp Leu Pro Pro Pro 
145                 150                 155                 160 


Glu Thr Pro Met Thr Ser His Ile Arg Tyr Glu Val Asp Val Ser Ala 
                165                 170                 175     


Gly Asn Gly Ala Gly Ser Val Gln Arg Val Glu Ile Leu Glu Gly Arg 
            180                 185                 190         


Thr Glu Cys Val Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe 
        195                 200                 205             


Ala Val Arg Ala Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser 
    210                 215                 220                 


Ala Trp Ser Glu Pro Val Ser Leu Leu Thr Pro Ser Asp Ile Leu Leu 
225                 230                 235                 240 


Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile Val Gly 
                245                 250                 255     


Ala Val Phe Leu Cys Ala Arg Arg Ser Arg Ala Ala Arg Gly Thr Ile 
            260                 265                 270         


Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val 
        275                 280                 285             


Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu 
    290                 295                 300                 


Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr 
305                 310                 315                 320 


Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg 
                325                 330                 335     


Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu 
            340                 345                 350         


Asp Gly His Cys Ser Trp Pro Leu Glu 
        355                 360     


<210>  64

<211>  299
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-exCID-n4

<400>  64
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His 
            20                  25                  30          


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
        35                  40                  45              


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
    50                  55                  60                  


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
65                  70                  75                  80  


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
                85                  90                  95      


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
            100                 105                 110         


Tyr His Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Thr Thr Thr Pro 
        115                 120                 125             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    130                 135                 140                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
145                 150                 155                 160 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Phe Trp Val Leu Val Val 
                165                 170                 175     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            180                 185                 190         


Ile Ile Phe Trp Val Arg Ser Lys Arg Arg Ser Arg Ala Ala Arg Gly 
        195                 200                 205             


Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser 
    210                 215                 220                 


Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp 
225                 230                 235                 240 


Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr 
                245                 250                 255     


Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro 
            260                 265                 270         


Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg 
        275                 280                 285             


Pro Glu Asp Gly His Cys Ser Trp Pro Leu Glu 
    290                 295                 


<210>  65

<211>  335
<212>  PRT
<213>  artificial sequence

<220>
<223>  &#947;-mcCAR-exCID-n1

<400>  65
Met Ala Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln 
1               5                   10                  15      


Ala Ala Ala Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Gly Ser Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    130                 135                 140                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
145                 150                 155                 160 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                165                 170                 175     


Ala Cys Asp Ile Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile 
            180                 185                 190         


Leu Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys 
        195                 200                 205             


Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Arg Val 
    210                 215                 220                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
225                 230                 235                 240 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                245                 250                 255     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            260                 265                 270         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        275                 280                 285             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    290                 295                 300                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
305                 310                 315                 320 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
                325                 330                 335 


<210>  66

<211>  511
<212>  PRT
<213>  artificial sequence

<220>
<223>  &#947;-mcCAR-exCID-n2

<400>  66
Met Ala Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln 
1               5                   10                  15      


Ala Ala Ala Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met 
            20                  25                  30          


Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg 
        35                  40                  45              


Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met 
    50                  55                  60                  


Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr 
65                  70                  75                  80  


Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys 
                85                  90                  95      


Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His 
            100                 105                 110         


Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Glu Pro Lys Ser Pro Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ala 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys Lys Asp Ile Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile 
        355                 360                 365             


Leu Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys 
    370                 375                 380                 


Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
            500                 505                 510     


<210>  67

<211>  391
<212>  PRT
<213>  artificial sequence

<220>
<223>  &#947;-mcCAR-exCID-n3

<400>  67
Met Ala Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln 
1               5                   10                  15      


Ala Ala Ala Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Gly Ser Gly Ala Pro Ala Pro Val Gly Leu Val Ala Arg Leu Ala 
    130                 135                 140                 


Asp Glu Ser Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Glu Thr 
145                 150                 155                 160 


Pro Met Thr Ser His Ile Arg Tyr Glu Val Asp Val Ser Ala Gly Asn 
                165                 170                 175     


Gly Ala Gly Ser Val Gln Arg Val Glu Ile Leu Glu Gly Arg Thr Glu 
            180                 185                 190         


Cys Val Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val 
        195                 200                 205             


Arg Ala Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp 
    210                 215                 220                 


Ser Glu Pro Val Ser Leu Leu Thr Pro Ser Asp Ile Gly Glu Pro Gln 
225                 230                 235                 240 


Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu 
                245                 250                 255     


Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile 
            260                 265                 270         


Thr Ser Tyr Glu Lys Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        275                 280                 285             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    290                 295                 300                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
305                 310                 315                 320 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                325                 330                 335     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            340                 345                 350         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        355                 360                 365             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    370                 375                 380                 


Gln Ala Leu Pro Pro Arg Glu 
385                 390     


<210>  68

<211>  323
<212>  PRT
<213>  artificial sequence

<220>
<223>  &#947;-mcCAR-exCID-n4

<400>  68
Met Ala Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln 
1               5                   10                  15      


Ala Ala Ala Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met 
            20                  25                  30          


Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg 
        35                  40                  45              


Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met 
    50                  55                  60                  


Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr 
65                  70                  75                  80  


Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys 
                85                  90                  95      


Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His 
            100                 105                 110         


Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Thr Thr Thr Pro Ala Pro 
        115                 120                 125             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    130                 135                 140                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
145                 150                 155                 160 


Gly Leu Asp Phe Ala Cys Asp Ile Gly Glu Pro Gln Leu Cys Tyr Ile 
                165                 170                 175     


Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr 
            180                 185                 190         


Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu 
        195                 200                 205             


Lys Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    210                 215                 220                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
225                 230                 235                 240 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                245                 250                 255     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            260                 265                 270         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        275                 280                 285             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    290                 295                 300                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
305                 310                 315                 320 


Pro Arg Glu 
            


<210>  69

<211>  290
<212>  PRT
<213>  artificial sequence

<220>
<223>  &#947;-mcCAR-exCID-n5

<400>  69
Met Ala Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln 
1               5                   10                  15      


Ala Ala Ala Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Gly Ser Gly Ala Pro Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu 
    130                 135                 140                 


Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys 
145                 150                 155                 160 


Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys 
                165                 170                 175     


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            180                 185                 190         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        195                 200                 205             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    210                 215                 220                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
225                 230                 235                 240 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                245                 250                 255     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            260                 265                 270         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        275                 280                 285             


Arg Glu 
    290 


<210>  70

<211>  278
<212>  PRT
<213>  artificial sequence

<220>
<223>  &#947;-mcCAR-exCID-n6

<400>  70
Met Ala Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln 
1               5                   10                  15      


Ala Ala Ala Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met 
            20                  25                  30          


Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg 
        35                  40                  45              


Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met 
    50                  55                  60                  


Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr 
65                  70                  75                  80  


Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys 
                85                  90                  95      


Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His 
            100                 105                 110         


Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Leu Gly Glu Pro Gln Leu 
        115                 120                 125             


Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu Thr 
    130                 135                 140                 


Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr 
145                 150                 155                 160 


Ser Tyr Glu Lys Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                165                 170                 175     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            180                 185                 190         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        195                 200                 205             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    210                 215                 220                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
225                 230                 235                 240 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                245                 250                 255     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            260                 265                 270         


Ala Leu Pro Pro Arg Glu 
        275             


<210>  71

<211>  546
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-exCID-n1

<400>  71
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
        275                 280                 285             


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
    290                 295                 300                 


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
305                 310                 315                 320 


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
                325                 330                 335     


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
            340                 345                 350         


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
        355                 360                 365             


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
    370                 375                 380                 


Lys Leu Glu Gly Ser Gly Ala Pro Ala Pro Val Gly Leu Val Ala Arg 
385                 390                 395                 400 


Leu Ala Asp Glu Ser Gly His Val Val Leu Arg Trp Leu Pro Pro Pro 
                405                 410                 415     


Glu Thr Pro Met Thr Ser His Ile Arg Tyr Glu Val Asp Val Ser Ala 
            420                 425                 430         


Gly Asn Gly Ala Gly Ser Val Gln Arg Val Glu Ile Leu Glu Gly Arg 
        435                 440                 445             


Thr Glu Cys Val Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe 
    450                 455                 460                 


Ala Val Arg Ala Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser 
465                 470                 475                 480 


Ala Trp Ser Glu Pro Val Ser Leu Leu Thr Pro Ser Asp Ile Phe Ile 
                485                 490                 495     


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
            500                 505                 510         


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
        515                 520                 525             


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
    530                 535                 540                 


Asn Glu 
545     


<210>  72

<211>  534
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-exCID-n2

<400>  72
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His 
        275                 280                 285             


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
    290                 295                 300                 


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
305                 310                 315                 320 


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
                325                 330                 335     


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
            340                 345                 350         


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
        355                 360                 365             


Tyr His Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Ala Pro Val Gly 
    370                 375                 380                 


Leu Val Ala Arg Leu Ala Asp Glu Ser Gly His Val Val Leu Arg Trp 
385                 390                 395                 400 


Leu Pro Pro Pro Glu Thr Pro Met Thr Ser His Ile Arg Tyr Glu Val 
                405                 410                 415     


Asp Val Ser Ala Gly Asn Gly Ala Gly Ser Val Gln Arg Val Glu Ile 
            420                 425                 430         


Leu Glu Gly Arg Thr Glu Cys Val Leu Ser Asn Leu Arg Gly Arg Thr 
        435                 440                 445             


Arg Tyr Thr Phe Ala Val Arg Ala Arg Met Ala Glu Pro Ser Phe Gly 
    450                 455                 460                 


Gly Phe Trp Ser Ala Trp Ser Glu Pro Val Ser Leu Leu Thr Pro Ser 
465                 470                 475                 480 


Asp Ile Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr 
                485                 490                 495     


Gly Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile 
            500                 505                 510         


Lys Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro 
        515                 520                 525             


Asn Pro Lys Asn Asn Glu 
    530                 


<210>  73

<211>  678
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-exCID-n3

<400>  73
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
        275                 280                 285             


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
    290                 295                 300                 


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
305                 310                 315                 320 


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
                325                 330                 335     


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
            340                 345                 350         


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
        355                 360                 365             


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
    370                 375                 380                 


Lys Leu Glu Gly Ser Gly Ala Pro Glu Pro Lys Ser Pro Asp Lys Thr 
385                 390                 395                 400 


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                405                 410                 415     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr 
            420                 425                 430         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        435                 440                 445             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    450                 455                 460                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
465                 470                 475                 480 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                485                 490                 495     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            500                 505                 510         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        515                 520                 525             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    530                 535                 540                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
545                 550                 555                 560 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                565                 570                 575     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            580                 585                 590         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        595                 600                 605             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys 
    610                 615                 620                 


Asp Ile Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr 
625                 630                 635                 640 


Gly Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile 
                645                 650                 655     


Lys Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro 
            660                 665                 670         


Asn Pro Lys Asn Asn Glu 
        675             


<210>  74

<211>  666
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-exCID-n4

<400>  74
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His 
        275                 280                 285             


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
    290                 295                 300                 


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
305                 310                 315                 320 


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
                325                 330                 335     


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
            340                 345                 350         


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
        355                 360                 365             


Tyr His Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Glu Pro Lys Ser 
    370                 375                 380                 


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
385                 390                 395                 400 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                405                 410                 415     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            420                 425                 430         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        435                 440                 445             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    450                 455                 460                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
465                 470                 475                 480 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                485                 490                 495     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            500                 505                 510         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        515                 520                 525             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    530                 535                 540                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
545                 550                 555                 560 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                565                 570                 575     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            580                 585                 590         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        595                 600                 605             


Pro Gly Lys Lys Asp Ile Phe Ile Pro Leu Leu Val Val Ile Leu Phe 
    610                 615                 620                 


Ala Val Asp Thr Gly Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe 
625                 630                 635                 640 


Leu Leu Lys Ile Lys Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro 
                645                 650                 655     


His Pro Lys Pro Asn Pro Lys Asn Asn Glu 
            660                 665     


<210>  75

<211>  490
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-exCID-n5

<400>  75
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
        275                 280                 285             


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
    290                 295                 300                 


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
305                 310                 315                 320 


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
                325                 330                 335     


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
            340                 345                 350         


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
        355                 360                 365             


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
    370                 375                 380                 


Lys Leu Glu Gly Ser Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro 
385                 390                 395                 400 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                405                 410                 415     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            420                 425                 430         


Asp Phe Ala Cys Asp Phe Phe Ile Pro Leu Leu Val Val Ile Leu Phe 
        435                 440                 445             


Ala Val Asp Thr Gly Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe 
    450                 455                 460                 


Leu Leu Lys Ile Lys Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro 
465                 470                 475                 480 


His Pro Lys Pro Asn Pro Lys Asn Asn Glu 
                485                 490 


<210>  76

<211>  478
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-exCID-n6

<400>  76
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His 
        275                 280                 285             


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
    290                 295                 300                 


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
305                 310                 315                 320 


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
                325                 330                 335     


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
            340                 345                 350         


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
        355                 360                 365             


Tyr His Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Thr Thr Thr Pro 
    370                 375                 380                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
385                 390                 395                 400 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                405                 410                 415     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe Ile Pro Leu Leu Val 
            420                 425                 430         


Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile Ser Thr Gln Gln 
        435                 440                 445             


Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg Lys Gly Phe Arg 
    450                 455                 460                 


Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn Asn Glu 
465                 470                 475             


<210>  77

<211>  608
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR extra CID n1

<400>  77
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
        195                 200                 205             


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Gly Ser Gly 
            260                 265                 270         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        275                 280                 285             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    290                 295                 300                 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
305                 310                 315                 320 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                325                 330                 335     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            340                 345                 350         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        355                 360                 365             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ala Pro 
    370                 375                 380                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
385                 390                 395                 400 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                405                 410                 415     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            420                 425                 430         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        435                 440                 445             


Ile Thr Leu Tyr Cys Arg Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    450                 455                 460                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
465                 470                 475                 480 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                485                 490                 495     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            500                 505                 510         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        515                 520                 525             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    530                 535                 540                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
545                 550                 555                 560 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                565                 570                 575     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            580                 585                 590         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
        595                 600                 605             






<210>  78

<211>  596
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR extra CID n2

<400>  78
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
        195                 200                 205             


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Gly Ser Gly 
            260                 265                 270         


Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
        275                 280                 285             


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
    290                 295                 300                 


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
305                 310                 315                 320 


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
                325                 330                 335     


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
            340                 345                 350         


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Gly 
        355                 360                 365             


Ser Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    370                 375                 380                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
385                 390                 395                 400 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                405                 410                 415     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            420                 425                 430         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Arg Gly Arg Lys Lys Leu 
        435                 440                 445             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    450                 455                 460                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
465                 470                 475                 480 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                485                 490                 495     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            500                 505                 510         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        515                 520                 525             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    530                 535                 540                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
545                 550                 555                 560 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                565                 570                 575     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            580                 585                 590         


Pro Pro Arg Glu 
        595     


<210>  79

<211>  796
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR extra CID n3

<400>  79
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
        195                 200                 205             


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Gly Ser Gly 
            260                 265                 270         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        275                 280                 285             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    290                 295                 300                 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
305                 310                 315                 320 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                325                 330                 335     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            340                 345                 350         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        355                 360                 365             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ala Pro 
    370                 375                 380                 


Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                405                 410                 415     


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
            420                 425                 430         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        435                 440                 445             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    450                 455                 460                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
465                 470                 475                 480 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                485                 490                 495     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            500                 505                 510         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        515                 520                 525             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    530                 535                 540                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
545                 550                 555                 560 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                565                 570                 575     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            580                 585                 590         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        595                 600                 605             


Leu Ser Leu Ser Pro Gly Lys Lys Asp Ile Tyr Ile Trp Ala Pro Leu 
    610                 615                 620                 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
625                 630                 635                 640 


Cys Arg Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
                645                 650                 655     


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            660                 665                 670         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
        675                 680                 685             


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
    690                 695                 700                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
705                 710                 715                 720 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                725                 730                 735     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            740                 745                 750         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        755                 760                 765             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    770                 775                 780                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
785                 790                 795     


<210>  80

<211>  784
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR extra CID n4

<400>  80
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
        195                 200                 205             


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Gly Ser Gly 
            260                 265                 270         


Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
        275                 280                 285             


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
    290                 295                 300                 


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
305                 310                 315                 320 


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
                325                 330                 335     


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
            340                 345                 350         


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Gly 
        355                 360                 365             


Ser Gly Ala Pro Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro 
    370                 375                 380                 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
385                 390                 395                 400 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr 
                405                 410                 415     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            420                 425                 430         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        435                 440                 445             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    450                 455                 460                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
465                 470                 475                 480 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                485                 490                 495     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            500                 505                 510         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        515                 520                 525             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    530                 535                 540                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
545                 550                 555                 560 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                565                 570                 575     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            580                 585                 590         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Ile Tyr Ile 
        595                 600                 605             


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    610                 615                 620                 


Ile Thr Leu Tyr Cys Arg Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
625                 630                 635                 640 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                645                 650                 655     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            660                 665                 670         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        675                 680                 685             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    690                 695                 700                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
705                 710                 715                 720 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                725                 730                 735     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            740                 745                 750         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        755                 760                 765             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
    770                 775                 780                 






<210>  81

<211>  664
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR extra CID n5

<400>  81
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
        195                 200                 205             


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Gly Ser Gly 
            260                 265                 270         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        275                 280                 285             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    290                 295                 300                 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
305                 310                 315                 320 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                325                 330                 335     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            340                 345                 350         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        355                 360                 365             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ala Pro 
    370                 375                 380                 


Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly His Val 
385                 390                 395                 400 


Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser His Ile 
                405                 410                 415     


Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser Val Gln 
            420                 425                 430         


Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser Asn Leu 
        435                 440                 445             


Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met Ala Glu 
    450                 455                 460                 


Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val Ser Leu 
465                 470                 475                 480 


Leu Thr Pro Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                485                 490                 495     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Arg Gly 
            500                 505                 510         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        515                 520                 525             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    530                 535                 540                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
545                 550                 555                 560 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                565                 570                 575     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            580                 585                 590         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        595                 600                 605             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    610                 615                 620                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
625                 630                 635                 640 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                645                 650                 655     


Met Gln Ala Leu Pro Pro Arg Glu 
            660                 


<210>  82

<211>  652
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR extra CID n6

<400>  82
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
        195                 200                 205             


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Gly Ser Gly 
            260                 265                 270         


Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
        275                 280                 285             


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
    290                 295                 300                 


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
305                 310                 315                 320 


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
                325                 330                 335     


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
            340                 345                 350         


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Gly 
        355                 360                 365             


Ser Gly Ala Pro Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu 
    370                 375                 380                 


Ser Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met 
385                 390                 395                 400 


Thr Ser His Ile Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala 
                405                 410                 415     


Gly Ser Val Gln Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val 
            420                 425                 430         


Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala 
        435                 440                 445             


Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu 
    450                 455                 460                 


Pro Val Ser Leu Leu Thr Pro Ser Asp Ile Tyr Ile Trp Ala Pro Leu 
465                 470                 475                 480 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                485                 490                 495     


Cys Arg Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            500                 505                 510         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        515                 520                 525             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    530                 535                 540                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
545                 550                 555                 560 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                565                 570                 575     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            580                 585                 590         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        595                 600                 605             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    610                 615                 620                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
625                 630                 635                 640 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
                645                 650         


<210>  83

<211>  260
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n1

<400>  83
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
    50                  55                  60                  


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
65                  70                  75                  80  


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
                85                  90                  95      


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
            100                 105                 110         


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
        115                 120                 125             


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
    130                 135                 140                 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr 
                165                 170                 175     


Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val 
            180                 185                 190         


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
        195                 200                 205             


Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
    210                 215                 220                 


Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp 
225                 230                 235                 240 


Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser 
                245                 250                 255     


Trp Pro Leu Glu 
            260 


<210>  84

<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n2

<400>  84
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu 
    50                  55                  60                  


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
65                  70                  75                  80  


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
                85                  90                  95      


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
            100                 105                 110         


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
        115                 120                 125             


Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
    130                 135                 140                 


Arg Ile Gly Ser Gly Ser Ser Ser Arg Ala Ala Arg Gly Thr Ile Gly 
145                 150                 155                 160 


Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro 
                165                 170                 175     


Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys 
            180                 185                 190         


Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala 
        195                 200                 205             


Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg 
    210                 215                 220                 


Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Gly His Cys Ser Trp Pro Leu Glu 
                245             


<210>  85

<211>  310
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n3

<400>  85
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
    50                  55                  60                  


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
65                  70                  75                  80  


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Gly Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Ser Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
            100                 105                 110         


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
        115                 120                 125             


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
    130                 135                 140                 


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
145                 150                 155                 160 


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
                165                 170                 175     


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
            180                 185                 190         


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
        195                 200                 205             


Gly Ser Gly Ser Gly Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg 
    210                 215                 220                 


Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe 
225                 230                 235                 240 


Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro 
                245                 250                 255     


Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile 
            260                 265                 270         


Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser 
        275                 280                 285             


Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His 
    290                 295                 300                 


Cys Ser Trp Pro Leu Glu 
305                 310 


<210>  86

<211>  288
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n4

<400>  86
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn 
    50                  55                  60                  


Met Pro Gly Arg Gly Gly Ser Gly Ser Gly Ser Gly Ser Ser Gly Gly 
65                  70                  75                  80  


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
                85                  90                  95      


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
            100                 105                 110         


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
        115                 120                 125             


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
    130                 135                 140                 


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
145                 150                 155                 160 


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
                165                 170                 175     


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ser Gly Ser 
            180                 185                 190         


Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu 
        195                 200                 205             


Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu 
    210                 215                 220                 


Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys 
225                 230                 235                 240 


Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met 
                245                 250                 255     


Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser 
            260                 265                 270         


Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Glu 
        275                 280                 285             






<210>  87

<211>  328
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n5

<400>  87
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile 
    50                  55                  60                  


Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val 
65                  70                  75                  80  


Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu 
                85                  90                  95      


Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Gly Ser Gly 
            100                 105                 110         


Ser Gly Ser Gly Ser Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro 
        115                 120                 125             


Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His 
    130                 135                 140                 


Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp 
145                 150                 155                 160 


Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg 
                165                 170                 175     


Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys 
            180                 185                 190         


Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly 
        195                 200                 205             


Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys 
    210                 215                 220                 


Leu Glu Gly Ser Gly Ser Gly Ser Arg Ala Ala Arg Gly Thr Ile Gly 
225                 230                 235                 240 


Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro 
                245                 250                 255     


Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys 
            260                 265                 270         


Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala 
        275                 280                 285             


Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg 
    290                 295                 300                 


Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp 
305                 310                 315                 320 


Gly His Cys Ser Trp Pro Leu Glu 
                325             


<210>  88

<211>  298
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n6

<400>  88
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
    50                  55                  60                  


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
65                  70                  75                  80  


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Gly Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Ser Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp 
            100                 105                 110         


His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn 
        115                 120                 125             


Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu 
    130                 135                 140                 


Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly 
145                 150                 155                 160 


Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser 
                165                 170                 175     


Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val 
            180                 185                 190         


Phe Arg Arg Ile Gly Ser Gly Ser Gly Ser Arg Ala Ala Arg Gly Thr 
        195                 200                 205             


Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala 
    210                 215                 220                 


Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg 
225                 230                 235                 240 


Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu 
                245                 250                 255     


Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala 
            260                 265                 270         


Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro 
        275                 280                 285             


Glu Asp Gly His Cys Ser Trp Pro Leu Glu 
    290                 295             


<210>  89

<211>  276
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n7

<400>  89
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn 
    50                  55                  60                  


Met Pro Gly Arg Gly Gly Ser Gly Ser Gly Ser Gly Ser Ser Gly Gly 
65                  70                  75                  80  


Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
                85                  90                  95      


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
            100                 105                 110         


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
        115                 120                 125             


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
    130                 135                 140                 


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
145                 150                 155                 160 


Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Gly Ser 
                165                 170                 175     


Gly Ser Gly Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr 
            180                 185                 190         


Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val 
        195                 200                 205             


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
    210                 215                 220                 


Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
225                 230                 235                 240 


Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp 
                245                 250                 255     


Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser 
            260                 265                 270         


Trp Pro Leu Glu 
        275     


<210>  90

<211>  316
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n8

<400>  90
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile 
    50                  55                  60                  


Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val 
65                  70                  75                  80  


Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu 
                85                  90                  95      


Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Gly Ser Gly 
            100                 105                 110         


Ser Gly Ser Gly Ser Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu 
        115                 120                 125             


Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu 
    130                 135                 140                 


Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met 
145                 150                 155                 160 


Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala 
                165                 170                 175     


Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met 
            180                 185                 190         


Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr 
        195                 200                 205             


His Val Phe Arg Arg Ile Gly Ser Gly Ser Gly Ser Arg Ala Ala Arg 
    210                 215                 220                 


Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro 
225                 230                 235                 240 


Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln 
                245                 250                 255     


Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln 
            260                 265                 270         


Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser 
        275                 280                 285             


Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu 
    290                 295                 300                 


Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Glu 
305                 310                 315     


<210>  91

<211>  260
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n9

<400>  91
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
    50                  55                  60                  


Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr 
65                  70                  75                  80  


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val 
                85                  90                  95      


Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser 
            100                 105                 110         


Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro 
        115                 120                 125             


Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro 
    130                 135                 140                 


Leu Gly Ser Gly Ser Ser Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
145                 150                 155                 160 


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
                165                 170                 175     


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
            180                 185                 190         


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
        195                 200                 205             


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
    210                 215                 220                 


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
225                 230                 235                 240 


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
                245                 250                 255     


Lys Leu Glu Glu 
            260 


<210>  92

<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n10

<400>  92
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
    50                  55                  60                  


Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr 
65                  70                  75                  80  


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val 
                85                  90                  95      


Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser 
            100                 105                 110         


Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro 
        115                 120                 125             


Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro 
    130                 135                 140                 


Leu Gly Ser Gly Ser Ser Ser Gly Gly Arg Val Ala Ile Leu Trp His 
145                 150                 155                 160 


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
                165                 170                 175     


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
            180                 185                 190         


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
        195                 200                 205             


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
    210                 215                 220                 


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
225                 230                 235                 240 


Tyr His Val Phe Arg Arg Ile Glu 
                245             


<210>  93

<211>  308
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n11

<400>  93
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
    50                  55                  60                  


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
65                  70                  75                  80  


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Gly Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Ser Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr 
            100                 105                 110         


Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val 
        115                 120                 125             


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
    130                 135                 140                 


Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
145                 150                 155                 160 


Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp 
                165                 170                 175     


Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser 
            180                 185                 190         


Trp Pro Leu Gly Ser Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
        195                 200                 205             


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
    210                 215                 220                 


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
225                 230                 235                 240 


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
                245                 250                 255     


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
            260                 265                 270         


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
        275                 280                 285             


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
    290                 295                 300                 


Lys Leu Glu Glu 
305             


<210>  94

<211>  286
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n12

<400>  94
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn 
    50                  55                  60                  


Met Pro Gly Arg Gly Gly Ser Gly Ser Gly Ser Gly Ser Ser Arg Ala 
65                  70                  75                  80  


Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu 
                85                  90                  95      


Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp 
            100                 105                 110         


Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro 
        115                 120                 125             


Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr 
    130                 135                 140                 


Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln 
145                 150                 155                 160 


Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Gly Ser Gly 
                165                 170                 175     


Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
            180                 185                 190         


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
        195                 200                 205             


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
    210                 215                 220                 


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
225                 230                 235                 240 


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
                245                 250                 255     


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
            260                 265                 270         


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Glu 
        275                 280                 285     


<210>  95

<211>  326
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n13

<400>  95
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile 
    50                  55                  60                  


Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val 
65                  70                  75                  80  


Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu 
                85                  90                  95      


Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Gly Ser Gly 
            100                 105                 110         


Ser Gly Ser Gly Ser Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg 
        115                 120                 125             


Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe 
    130                 135                 140                 


Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro 
145                 150                 155                 160 


Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile 
                165                 170                 175     


Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser 
            180                 185                 190         


Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His 
        195                 200                 205             


Cys Ser Trp Pro Leu Gly Ser Gly Ser Gly Gly Val Gln Val Glu Thr 
    210                 215                 220                 


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
225                 230                 235                 240 


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
                245                 250                 255     


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
            260                 265                 270         


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
        275                 280                 285             


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
    290                 295                 300                 


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
305                 310                 315                 320 


Leu Leu Lys Leu Glu Glu 
                325     


<210>  96

<211>  296
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n14

<400>  96
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
    50                  55                  60                  


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
65                  70                  75                  80  


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Gly Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Ser Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr 
            100                 105                 110         


Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val 
        115                 120                 125             


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
    130                 135                 140                 


Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
145                 150                 155                 160 


Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp 
                165                 170                 175     


Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser 
            180                 185                 190         


Trp Pro Leu Gly Ser Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His 
        195                 200                 205             


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
    210                 215                 220                 


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
225                 230                 235                 240 


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
                245                 250                 255     


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
            260                 265                 270         


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
        275                 280                 285             


Tyr His Val Phe Arg Arg Ile Glu 
    290                 295     


<210>  97

<211>  274
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n15

<400>  97
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn 
    50                  55                  60                  


Met Pro Gly Arg Gly Gly Ser Gly Ser Gly Ser Gly Ser Ser Arg Ala 
65                  70                  75                  80  


Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu 
                85                  90                  95      


Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp 
            100                 105                 110         


Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro 
        115                 120                 125             


Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr 
    130                 135                 140                 


Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln 
145                 150                 155                 160 


Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Gly Ser Gly 
                165                 170                 175     


Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly 
            180                 185                 190         


Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly 
        195                 200                 205             


Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro 
    210                 215                 220                 


Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu 
225                 230                 235                 240 


Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val 
                245                 250                 255     


Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg 
            260                 265                 270         


Ile Glu 
        


<210>  98

<211>  314
<212>  PRT
<213>  artificial sequence

<220>
<223>  IMP-intCID-n16

<400>  98
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            20                  25                  30          


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        35                  40                  45              


Arg Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile 
    50                  55                  60                  


Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val 
65                  70                  75                  80  


Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu 
                85                  90                  95      


Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Gly Ser Gly 
            100                 105                 110         


Ser Gly Ser Gly Ser Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg 
        115                 120                 125             


Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe 
    130                 135                 140                 


Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro 
145                 150                 155                 160 


Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile 
                165                 170                 175     


Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser 
            180                 185                 190         


Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His 
        195                 200                 205             


Cys Ser Trp Pro Leu Gly Ser Gly Ser Gly Gly Arg Val Ala Ile Leu 
    210                 215                 220                 


Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr 
225                 230                 235                 240 


Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu 
                245                 250                 255     


His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe 
            260                 265                 270         


Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg 
        275                 280                 285             


Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp 
    290                 295                 300                 


Leu Tyr Tyr His Val Phe Arg Arg Ile Glu 
305                 310                 


<210>  99

<211>  481
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-intCID-n1

<400>  99
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Gln Ile Gln Leu Val Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
    50                  55                  60                  


Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr 
65                  70                  75                  80  


Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser 
                85                  90                  95      


Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys 
            100                 105                 110         


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp 
        115                 120                 125             


Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn 
            180                 185                 190         


Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
                245                 250                 255     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe 
305                 310                 315                 320 


Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe 
                325                 330                 335     


Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr 
            340                 345                 350         


Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys 
        355                 360                 365             


Asn Asn Arg Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
    370                 375                 380                 


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
385                 390                 395                 400 


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
                405                 410                 415     


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
            420                 425                 430         


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
        435                 440                 445             


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
    450                 455                 460                 


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
465                 470                 475                 480 


Glu 
    


<210>  100

<211>  469
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-intCID-n2

<400>  100
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Gln Ile Gln Leu Val Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
    50                  55                  60                  


Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr 
65                  70                  75                  80  


Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser 
                85                  90                  95      


Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys 
            100                 105                 110         


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp 
        115                 120                 125             


Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn 
            180                 185                 190         


Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
                245                 250                 255     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe 
305                 310                 315                 320 


Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe 
                325                 330                 335     


Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr 
            340                 345                 350         


Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys 
        355                 360                 365             


Asn Asn Arg Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp 
    370                 375                 380                 


His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn 
385                 390                 395                 400 


Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu 
                405                 410                 415     


Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly 
            420                 425                 430         


Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser 
        435                 440                 445             


Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val 
    450                 455                 460                 


Phe Arg Arg Ile Glu 
465                 


<210>  101

<211>  531
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-intCID-n3

<400>  101
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Gln Ile Gln Leu Val Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
    50                  55                  60                  


Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr 
65                  70                  75                  80  


Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser 
                85                  90                  95      


Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys 
            100                 105                 110         


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp 
        115                 120                 125             


Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn 
            180                 185                 190         


Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
                245                 250                 255     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe 
305                 310                 315                 320 


Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe 
                325                 330                 335     


Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr 
            340                 345                 350         


Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys 
        355                 360                 365             


Asn Asn Arg Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro 
    370                 375                 380                 


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
385                 390                 395                 400 


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Gly Ser Gly 
                405                 410                 415     


Ser Gly Ser Gly Ser Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro 
            420                 425                 430         


Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His 
        435                 440                 445             


Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp 
    450                 455                 460                 


Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg 
465                 470                 475                 480 


Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys 
                485                 490                 495     


Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly 
            500                 505                 510         


Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys 
        515                 520                 525             


Leu Glu Glu 
    530     


<210>  102

<211>  509
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-intCID-n4

<400>  102
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Gln Ile Gln Leu Val Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
    50                  55                  60                  


Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr 
65                  70                  75                  80  


Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser 
                85                  90                  95      


Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys 
            100                 105                 110         


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp 
        115                 120                 125             


Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn 
            180                 185                 190         


Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
                245                 250                 255     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe 
305                 310                 315                 320 


Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe 
                325                 330                 335     


Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr 
            340                 345                 350         


Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys 
        355                 360                 365             


Asn Asn Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr 
    370                 375                 380                 


Ile Asn Met Pro Gly Arg Gly Gly Ser Gly Ser Gly Ser Gly Ser Ser 
385                 390                 395                 400 


Gly Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
                405                 410                 415     


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            420                 425                 430         


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        435                 440                 445             


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    450                 455                 460                 


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
465                 470                 475                 480 


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                485                 490                 495     


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Glu 
            500                 505                 


<210>  103

<211>  549
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-intCID-n5

<400>  103
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Gln Ile Gln Leu Val Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
    50                  55                  60                  


Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr 
65                  70                  75                  80  


Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser 
                85                  90                  95      


Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys 
            100                 105                 110         


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp 
        115                 120                 125             


Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn 
            180                 185                 190         


Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
                245                 250                 255     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe 
305                 310                 315                 320 


Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe 
                325                 330                 335     


Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr 
            340                 345                 350         


Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys 
        355                 360                 365             


Asn Asn Arg Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys 
    370                 375                 380                 


Val Ile Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala 
385                 390                 395                 400 


Thr Val Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala 
                405                 410                 415     


Val Glu Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Gly 
            420                 425                 430         


Ser Gly Ser Gly Ser Gly Ser Ser Gly Gly Val Gln Val Glu Thr Ile 
        435                 440                 445             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    450                 455                 460                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
465                 470                 475                 480 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                485                 490                 495     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            500                 505                 510         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        515                 520                 525             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    530                 535                 540                 


Leu Lys Leu Glu Glu 
545                 


<210>  104

<211>  519
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-intCID-n6

<400>  104
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Gln Ile Gln Leu Val Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
    50                  55                  60                  


Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr 
65                  70                  75                  80  


Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser 
                85                  90                  95      


Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys 
            100                 105                 110         


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp 
        115                 120                 125             


Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn 
            180                 185                 190         


Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
                245                 250                 255     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe 
305                 310                 315                 320 


Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe 
                325                 330                 335     


Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr 
            340                 345                 350         


Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys 
        355                 360                 365             


Asn Asn Arg Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro 
    370                 375                 380                 


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
385                 390                 395                 400 


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Gly Ser Gly 
                405                 410                 415     


Ser Gly Ser Gly Ser Ser Gly Gly Arg Val Ala Ile Leu Trp His Glu 
            420                 425                 430         


Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu 
        435                 440                 445             


Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met 
    450                 455                 460                 


Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala 
465                 470                 475                 480 


Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met 
                485                 490                 495     


Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr 
            500                 505                 510         


His Val Phe Arg Arg Ile Glu 
        515                 


<210>  105

<211>  497
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-intCID-n7

<400>  105
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Gln Ile Gln Leu Val Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
    50                  55                  60                  


Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr 
65                  70                  75                  80  


Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser 
                85                  90                  95      


Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys 
            100                 105                 110         


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp 
        115                 120                 125             


Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn 
            180                 185                 190         


Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
                245                 250                 255     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe 
305                 310                 315                 320 


Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe 
                325                 330                 335     


Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr 
            340                 345                 350         


Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys 
        355                 360                 365             


Asn Asn Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr 
    370                 375                 380                 


Ile Asn Met Pro Gly Arg Gly Gly Ser Gly Ser Gly Ser Gly Ser Ser 
385                 390                 395                 400 


Gly Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
                405                 410                 415     


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
            420                 425                 430         


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
        435                 440                 445             


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
    450                 455                 460                 


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
465                 470                 475                 480 


Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
                485                 490                 495     


Glu 
    


<210>  106

<211>  537
<212>  PRT
<213>  artificial sequence

<220>
<223>  alpha-mcCAR-intCID-n8

<400>  106
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Gln Ile Gln Leu Val Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
    50                  55                  60                  


Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr 
65                  70                  75                  80  


Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser 
                85                  90                  95      


Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys 
            100                 105                 110         


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp 
        115                 120                 125             


Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn 
            180                 185                 190         


Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
                245                 250                 255     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe 
305                 310                 315                 320 


Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe 
                325                 330                 335     


Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr 
            340                 345                 350         


Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys 
        355                 360                 365             


Asn Asn Arg Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys 
    370                 375                 380                 


Val Ile Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala 
385                 390                 395                 400 


Thr Val Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala 
                405                 410                 415     


Val Glu Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Gly 
            420                 425                 430         


Ser Gly Ser Gly Ser Gly Ser Ser Gly Gly Arg Val Ala Ile Leu Trp 
        435                 440                 445             


His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
    450                 455                 460                 


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
465                 470                 475                 480 


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
                485                 490                 495     


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
            500                 505                 510         


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu 
        515                 520                 525             


Tyr Tyr His Val Phe Arg Arg Ile Glu 
    530                 535         


<210>  107

<211>  613
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR-intraCID-n1

<400>  107
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                325                 330                 335     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Arg Gly Arg 
            340                 345                 350         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        355                 360                 365             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    370                 375                 380                 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
385                 390                 395                 400 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                405                 410                 415     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            420                 425                 430         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        435                 440                 445             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    450                 455                 460                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
465                 470                 475                 480 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                485                 490                 495     


Gln Ala Leu Pro Pro Arg Ser Ser Gly Gly Val Gln Val Glu Thr Ile 
            500                 505                 510         


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
        515                 520                 525             


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
    530                 535                 540                 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
545                 550                 555                 560 


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
                565                 570                 575     


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
            580                 585                 590         


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
        595                 600                 605             


Leu Lys Leu Glu Glu 
    610             


<210>  108

<211>  601
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR-intraCID-n2

<400>  108
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                325                 330                 335     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Arg Gly Arg 
            340                 345                 350         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        355                 360                 365             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    370                 375                 380                 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
385                 390                 395                 400 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                405                 410                 415     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            420                 425                 430         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        435                 440                 445             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    450                 455                 460                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
465                 470                 475                 480 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                485                 490                 495     


Gln Ala Leu Pro Pro Arg Ser Ser Gly Gly Arg Val Ala Ile Leu Trp 
            500                 505                 510         


His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
        515                 520                 525             


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
    530                 535                 540                 


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
545                 550                 555                 560 


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
                565                 570                 575     


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu 
            580                 585                 590         


Tyr Tyr His Val Phe Arg Arg Ile Glu 
        595                 600     


<210>  109

<211>  624
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR-intraCID-n3

<400>  109
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                325                 330                 335     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Ser Gly Gly 
385                 390                 395                 400 


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
                405                 410                 415     


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
            420                 425                 430         


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
        435                 440                 445             


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
    450                 455                 460                 


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
465                 470                 475                 480 


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
                485                 490                 495     


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ser Gly Arg 
            500                 505                 510         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        515                 520                 525             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    530                 535                 540                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
545                 550                 555                 560 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                565                 570                 575     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            580                 585                 590         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        595                 600                 605             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
    610                 615                 620                 






<210>  110

<211>  612
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR-intraCID-n4

<400>  110
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                325                 330                 335     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Ser Gly Gly 
385                 390                 395                 400 


Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
                405                 410                 415     


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
            420                 425                 430         


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
        435                 440                 445             


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
    450                 455                 460                 


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
465                 470                 475                 480 


Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Gly Ser 
                485                 490                 495     


Gly Ser Gly Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            500                 505                 510         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        515                 520                 525             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    530                 535                 540                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
545                 550                 555                 560 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                565                 570                 575     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            580                 585                 590         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        595                 600                 605             


Pro Pro Arg Glu 
    610         


<210>  111

<211>  617
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR-intraCID-n5

<400>  111
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                325                 330                 335     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Gly Gly 
            340                 345                 350         


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
        355                 360                 365             


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
    370                 375                 380                 


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
385                 390                 395                 400 


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
                405                 410                 415     


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
            420                 425                 430         


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
        435                 440                 445             


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ser Ser Arg 
    450                 455                 460                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
465                 470                 475                 480 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                485                 490                 495     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            500                 505                 510         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        515                 520                 525             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    530                 535                 540                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
545                 550                 555                 560 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                565                 570                 575     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            580                 585                 590         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        595                 600                 605             


His Met Gln Ala Leu Pro Pro Arg Glu 
    610                 615         


<210>  112

<211>  605
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123-scCAR-intraCID-n6

<400>  112
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                325                 330                 335     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Gly Gly 
            340                 345                 350         


Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
        355                 360                 365             


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
    370                 375                 380                 


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
385                 390                 395                 400 


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
                405                 410                 415     


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
            420                 425                 430         


Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Gly Ser 
        435                 440                 445             


Gly Ser Ser Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    450                 455                 460                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
465                 470                 475                 480 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                485                 490                 495     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            500                 505                 510         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        515                 520                 525             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    530                 535                 540                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
545                 550                 555                 560 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                565                 570                 575     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            580                 585                 590         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
        595                 600                 605 





