                         SEQUENCE LISTING

<110>  Conagen Inc.
       Mao, Guohong
       Yu, Xiaodan
       Luo, Yang
       Lin, Ying
 
<120>  NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING

<130>  32559-49

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Glu Asn Lys Thr Glu Thr Thr Val Arg Arg Arg Arg Arg Ile Ile 
1               5                   10                  15      


Leu Phe Pro Val Pro Phe Gln Gly His Ile Asn Pro Ile Leu Gln Leu 
            20                  25                  30          


Ala Asn Val Leu Tyr Ser Lys Gly Phe Ser Ile Thr Ile Phe His Thr 
        35                  40                  45              


Asn Phe Asn Lys Pro Lys Thr Ser Asn Tyr Pro His Phe Thr Phe Arg 
    50                  55                  60                  


Phe Ile Leu Asp Asn Asp Pro Gln Asp Glu Arg Ile Ser Asn Leu Pro 
65                  70                  75                  80  


Thr His Gly Pro Leu Ala Gly Met Arg Ile Pro Ile Ile Asn Glu His 
                85                  90                  95      


Gly Ala Asp Glu Leu Arg Arg Glu Leu Glu Leu Leu Met Leu Ala Ser 
            100                 105                 110         


Glu Glu Asp Glu Glu Val Ser Cys Leu Ile Thr Asp Ala Leu Trp Tyr 
        115                 120                 125             


Phe Ala Gln Ser Val Ala Asp Ser Leu Asn Leu Arg Arg Leu Val Leu 
    130                 135                 140                 


Met Thr Ser Ser Leu Phe Asn Phe His Ala His Val Ser Leu Pro Gln 
145                 150                 155                 160 


Phe Asp Glu Leu Gly Tyr Leu Asp Pro Asp Asp Lys Thr Arg Leu Glu 
                165                 170                 175     


Glu Gln Ala Ser Gly Phe Pro Met Leu Lys Val Lys Asp Ile Lys Ser 
            180                 185                 190         


Ala Tyr Ser Asn Trp Gln Ile Leu Lys Glu Ile Leu Gly Lys Met Ile 
        195                 200                 205             


Lys Gln Thr Lys Ala Ser Ser Gly Val Ile Trp Asn Ser Phe Lys Glu 
    210                 215                 220                 


Leu Glu Glu Ser Glu Leu Glu Thr Val Ile Arg Glu Ile Pro Ala Pro 
225                 230                 235                 240 


Ser Phe Leu Ile Pro Leu Pro Lys His Leu Thr Ala Ser Ser Ser Ser 
                245                 250                 255     


Leu Leu Asp His Asp Arg Thr Val Phe Gln Trp Leu Asp Gln Gln Pro 
            260                 265                 270         


Pro Ser Ser Val Leu Tyr Val Ser Phe Gly Ser Thr Ser Glu Val Asp 
        275                 280                 285             


Glu Lys Asp Phe Leu Glu Ile Ala Arg Gly Leu Val Asp Ser Lys Gln 
    290                 295                 300                 


Ser Phe Leu Trp Val Val Arg Pro Gly Phe Val Lys Gly Ser Thr Trp 
305                 310                 315                 320 


Val Glu Pro Leu Pro Asp Gly Phe Leu Gly Glu Arg Gly Arg Ile Val 
                325                 330                 335     


Lys Trp Val Pro Gln Gln Glu Val Leu Ala His Gly Ala Ile Gly Ala 
            340                 345                 350         


Phe Trp Thr His Ser Gly Trp Asn Ser Thr Leu Glu Ser Val Cys Glu 
        355                 360                 365             


Gly Val Pro Met Ile Phe Ser Asp Phe Gly Leu Asp Gln Pro Leu Asn 
    370                 375                 380                 


Ala Arg Tyr Met Ser Asp Val Leu Lys Val Gly Val Tyr Leu Glu Asn 
385                 390                 395                 400 


Gly Trp Glu Arg Gly Glu Ile Ala Asn Ala Ile Arg Arg Val Met Val 
                405                 410                 415     


Asp Glu Glu Gly Glu Tyr Ile Arg Gln Asn Ala Arg Val Leu Lys Gln 
            420                 425                 430         


Lys Ala Asp Val Ser Leu Met Lys Gly Gly Ser Ser Tyr Glu Ser Leu 
        435                 440                 445             


Glu Ser Leu Val Ser Tyr Ile Ser Ser Leu 
    450                 455             


<210>  2
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
atggagaata agacagaaac aaccgtaaga cggaggcgga ggattatctt gttccctgta       60

ccatttcagg gccatattaa tccgatcctc caattagcaa acgtcctcta ctccaaggga      120

ttttcaataa caatcttcca tactaacttt aacaagccta aaacgagtaa ttatcctcac      180

tttacattca ggttcattct agacaacgac cctcaggatg agcgtatctc aaatttacct      240

acgcatggcc ccttggcagg tatgcgaata ccaataatca atgagcatgg agccgatgaa      300

ctccgtcgcg agttagagct tctcatgctc gcaagtgagg aagacgagga agtttcgtgc      360

ctaataactg atgcgctttg gtacttcgcc caatcagtcg cagactcact gaatctacgc      420

cgtttggtcc ttatgacaag ttcattattc aactttcacg cacatgtatc actgccgcaa      480

tttgacgagt tgggttacct ggacccggat gacaaaacgc gattggagga acaagcgtcg      540

ggcttcccca tgctgaaagt caaagatatt aagagcgctt atagtaattg gcaaattctg      600

aaagaaattc tcggaaaaat gataaagcaa accaaagcgt cctctggagt aatctggaac      660

tccttcaagg agttagagga atctgaactt gaaacggtca tcagagaaat ccccgctccc      720

tcgttcttaa ttccactacc caagcacctt actgcaagta gcagttccct cctagatcat      780

gaccgaaccg tgtttcagtg gctggatcag caacccccgt cgtcagttct atatgtaagc      840

tttgggagta cttcggaagt ggatgaaaag gacttcttag agattgcgcg agggctcgtg      900

gatagcaaac agagcttcct gtgggtagtg agaccgggat tcgttaaggg ctcgacgtgg      960

gtcgagccgt tgccagatgg ttttctaggg gagagaggga gaatcgtgaa atgggttcca     1020

cagcaagagg ttttggctca cggagctata ggggcctttt ggacccactc tggttggaat     1080

tctactcttg aaagtgtctg tgaaggcgtt ccaatgatat tttctgattt tgggcttgac     1140

cagcctctaa acgctcgcta tatgtctgat gtgttgaagg ttggcgtgta cctggagaat     1200

ggttgggaaa ggggggaaat tgccaacgcc atacgccggg taatggtgga cgaggaaggt     1260

gagtacatac gtcagaacgc tcgggtttta aaacaaaaag cggacgtcag ccttatgaag     1320

ggaggtagct cctatgaatc cctagaatcc ttggtaagct atatatcttc gttataa        1377


<210>  3
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Asp Ser Gly Tyr Ser Ser Ser Tyr Ala Ala Ala Ala Gly Met His 
1               5                   10                  15      


Val Val Ile Cys Pro Trp Leu Ala Phe Gly His Leu Leu Pro Cys Leu 
            20                  25                  30          


Asp Leu Ala Gln Arg Leu Ala Ser Arg Gly His Arg Val Ser Phe Val 
        35                  40                  45              


Ser Thr Pro Arg Asn Ile Ser Arg Leu Pro Pro Val Arg Pro Ala Leu 
    50                  55                  60                  


Ala Pro Leu Val Ala Phe Val Ala Leu Pro Leu Pro Arg Val Glu Gly 
65                  70                  75                  80  


Leu Pro Asp Gly Ala Glu Ser Thr Asn Asp Val Pro His Asp Arg Pro 
                85                  90                  95      


Asp Met Val Glu Leu His Arg Arg Ala Phe Asp Gly Leu Ala Ala Pro 
            100                 105                 110         


Phe Ser Glu Phe Leu Gly Thr Ala Cys Ala Asp Trp Val Ile Val Asp 
        115                 120                 125             


Val Phe His His Trp Ala Ala Ala Ala Ala Leu Glu His Lys Val Pro 
    130                 135                 140                 


Cys Ala Met Met Leu Leu Gly Ser Ala His Met Ile Ala Ser Ile Ala 
145                 150                 155                 160 


Asp Arg Arg Leu Glu Arg Ala Glu Thr Glu Ser Pro Ala Ala Ala Gly 
                165                 170                 175     


Gln Gly Arg Pro Ala Ala Ala Pro Thr Phe Glu Val Ala Arg Met Lys 
            180                 185                 190         


Leu Ile Arg Thr Lys Gly Ser Ser Gly Met Ser Leu Ala Glu Arg Phe 
        195                 200                 205             


Ser Leu Thr Leu Ser Arg Ser Ser Leu Val Val Gly Arg Ser Cys Val 
    210                 215                 220                 


Glu Phe Glu Pro Glu Thr Val Pro Leu Leu Ser Thr Leu Arg Gly Lys 
225                 230                 235                 240 


Pro Ile Thr Phe Leu Gly Leu Met Pro Pro Leu His Glu Gly Arg Arg 
                245                 250                 255     


Glu Asp Gly Glu Asp Ala Thr Val Arg Trp Leu Asp Ala Gln Pro Ala 
            260                 265                 270         


Lys Ser Val Val Tyr Val Ala Leu Gly Ser Glu Val Pro Leu Gly Val 
        275                 280                 285             


Glu Lys Val His Glu Leu Ala Leu Gly Leu Glu Leu Ala Gly Thr Arg 
    290                 295                 300                 


Phe Leu Trp Ala Leu Arg Lys Pro Thr Gly Val Ser Asp Ala Asp Leu 
305                 310                 315                 320 


Leu Pro Ala Gly Phe Glu Glu Arg Thr Arg Gly Arg Gly Val Val Ala 
                325                 330                 335     


Thr Arg Trp Val Pro Gln Met Ser Ile Leu Ala His Ala Ala Val Gly 
            340                 345                 350         


Ala Phe Leu Thr His Cys Gly Trp Asn Ser Thr Ile Glu Gly Leu Met 
        355                 360                 365             


Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Gly Asp Gln Gly Pro 
    370                 375                 380                 


Asn Ala Arg Leu Ile Glu Ala Lys Asn Ala Gly Leu Gln Val Ala Arg 
385                 390                 395                 400 


Asn Asp Gly Asp Gly Ser Phe Asp Arg Glu Gly Val Ala Ala Ala Ile 
                405                 410                 415     


Arg Ala Val Ala Val Glu Glu Glu Ser Ser Lys Val Phe Gln Ala Lys 
            420                 425                 430         


Ala Lys Lys Leu Gln Glu Ile Val Ala Asp Met Ala Cys His Glu Arg 
        435                 440                 445             


Tyr Ile Asp Gly Phe Ile Gln Gln Leu Arg Ser Tyr Lys Asp 
    450                 455                 460         


<210>  4
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
atggattcgg gttactcttc ctcctatgcg gcggctgcgg gtatgcacgt tgttatctgt       60

ccgtggctgg cttttggtca cctgctgccg tgcctggatc tggcacagcg tctggcttca      120

cgcggccatc gtgtcagctt cgtgtctacc ccgcgcaata tttcgcgtct gccgccggtt      180

cgtccggcac tggctccgct ggttgcattt gtcgctctgc cgctgccgcg cgtggaaggt      240

ctgccggatg gtgcggaaag taccaacgac gtgccgcatg atcgcccgga catggttgaa      300

ctgcaccgtc gtgcattcga tggtctggca gcaccgtttt ccgaatttct gggtacggcg      360

tgcgccgatt gggtgatcgt tgacgtcttt catcactggg cggcggcggc ggcgctggaa      420

cataaagttc cgtgtgcaat gatgctgctg ggctcagctc acatgattgc gtcgatcgca      480

gaccgtcgcc tggaacgtgc agaaaccgaa agtccggctg cggccggcca gggtcgcccg      540

gcagctgcgc cgaccttcga agtggcccgc atgaaactga ttcgtacgaa aggcagctct      600

ggtatgagcc tggcagaacg ctttagtctg accctgtccc gtagttccct ggtggttggt      660

cgcagttgcg ttgaatttga accggaaacc gtcccgctgc tgtccacgct gcgtggtaaa      720

ccgatcacct ttctgggtct gatgccgccg ctgcatgaag gccgtcgcga agatggtgaa      780

gacgcaacgg tgcgttggct ggatgcacag ccggctaaaa gcgtcgtgta tgtcgccctg      840

ggctctgaag tgccgctggg tgtggaaaaa gttcacgaac tggcactggg cctggaactg      900

gctggcaccc gcttcctgtg ggcactgcgt aaaccgacgg gtgtgagcga tgcggacctg      960

ctgccggccg gttttgaaga acgtacccgc ggccgtggtg ttgtcgcaac gcgttgggtc     1020

ccgcaaatga gcattctggc gcatgccgca gtgggcgcct ttctgaccca ctgtggttgg     1080

aacagcacga tcgaaggcct gatgtttggt cacccgctga ttatgctgcc gatcttcggc     1140

gatcagggtc cgaacgcacg tctgattgaa gcgaaaaatg ccggcctgca agttgcgcgc     1200

aacgatggcg acggttcttt cgaccgtgag ggtgtggctg cggccattcg cgcagtggct     1260

gttgaagaag aatcatcgaa agtttttcag gcgaaagcca aaaaactgca agaaatcgtc     1320

gcggatatgg cctgccacga acgctacatt gatggtttca ttcagcaact gcgctcctac     1380

aaagactaa                                                             1389


<210>  5
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Asp Gly Asn Ser Ser Ser Ser Pro Leu His Val Val Ile Cys Pro 
1               5                   10                  15      


Trp Leu Ala Leu Gly His Leu Leu Pro Cys Leu Asp Ile Ala Glu Arg 
            20                  25                  30          


Leu Ala Ser Arg Gly His Arg Val Ser Phe Val Ser Thr Pro Arg Asn 
        35                  40                  45              


Ile Ala Arg Leu Pro Pro Leu Arg Pro Ala Val Ala Pro Leu Val Asp 
    50                  55                  60                  


Phe Val Ala Leu Pro Leu Pro His Val Asp Gly Leu Pro Glu Gly Ala 
65                  70                  75                  80  


Glu Ser Thr Asn Asp Val Pro Tyr Asp Lys Phe Glu Leu His Arg Lys 
                85                  90                  95      


Ala Phe Asp Gly Leu Ala Ala Pro Phe Ser Glu Phe Leu Arg Ala Ala 
            100                 105                 110         


Cys Ala Glu Gly Ala Gly Ser Arg Pro Asp Trp Leu Ile Val Asp Thr 
        115                 120                 125             


Phe His His Trp Ala Ala Ala Ala Ala Val Glu Asn Lys Val Pro Cys 
    130                 135                 140                 


Val Met Leu Leu Leu Gly Ala Ala Thr Val Ile Ala Gly Phe Ala Arg 
145                 150                 155                 160 


Gly Val Ser Glu His Ala Ala Ala Ala Val Gly Lys Glu Arg Pro Ala 
                165                 170                 175     


Ala Glu Ala Pro Ser Phe Glu Thr Glu Arg Arg Lys Leu Met Thr Thr 
            180                 185                 190         


Gln Asn Ala Ser Gly Met Thr Val Ala Glu Arg Tyr Phe Leu Thr Leu 
        195                 200                 205             


Met Arg Ser Asp Leu Val Ala Ile Arg Ser Cys Ala Glu Trp Glu Pro 
    210                 215                 220                 


Glu Ser Val Ala Ala Leu Thr Thr Leu Ala Gly Lys Pro Val Val Pro 
225                 230                 235                 240 


Leu Gly Leu Leu Pro Pro Ser Pro Glu Gly Gly Arg Gly Val Ser Lys 
                245                 250                 255     


Glu Asp Ala Ala Val Arg Trp Leu Asp Ala Gln Pro Ala Lys Ser Val 
            260                 265                 270         


Val Tyr Val Ala Leu Gly Ser Glu Val Pro Leu Arg Ala Glu Gln Val 
        275                 280                 285             


His Glu Leu Ala Leu Gly Leu Glu Leu Ser Gly Ala Arg Phe Leu Trp 
    290                 295                 300                 


Ala Leu Arg Lys Pro Thr Asp Ala Pro Asp Ala Ala Val Leu Pro Pro 
305                 310                 315                 320 


Gly Phe Glu Glu Arg Thr Arg Gly Arg Gly Leu Val Val Thr Gly Trp 
                325                 330                 335     


Val Pro Gln Ile Gly Val Leu Ala His Gly Ala Val Ala Ala Phe Leu 
            340                 345                 350         


Thr His Cys Gly Trp Asn Ser Thr Ile Glu Gly Leu Leu Phe Gly His 
        355                 360                 365             


Pro Leu Ile Met Leu Pro Ile Ser Ser Asp Gln Gly Pro Asn Ala Arg 
    370                 375                 380                 


Leu Met Glu Gly Arg Lys Val Gly Met Gln Val Pro Arg Asp Glu Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Arg Arg Glu Asp Val Ala Ala Thr Val Arg Ala Val 
                405                 410                 415     


Ala Val Glu Glu Asp Gly Arg Arg Val Phe Thr Ala Asn Ala Lys Lys 
            420                 425                 430         


Met Gln Glu Ile Val Ala Asp Gly Ala Cys His Glu Arg Cys Ile Asp 
        435                 440                 445             


Gly Phe Ile Gln Gln Leu Arg Ser Tyr Lys Ala 
    450                 455                 


<210>  6
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
atggatggta actcctcctc ctcgccgctg catgtggtca tttgtccgtg gctggctctg       60

ggtcacctgc tgccgtgtct ggatattgct gaacgtctgg cgtcacgcgg ccatcgtgtc      120

agttttgtgt ccaccccgcg caacattgcc cgtctgccgc cgctgcgtcc ggctgttgca      180

ccgctggttg atttcgtcgc actgccgctg ccgcatgttg acggtctgcc ggagggtgcg      240

gaatcgacca atgatgtgcc gtatgacaaa tttgaactgc accgtaaggc gttcgatggt      300

ctggcggccc cgtttagcga atttctgcgt gcagcttgcg cagaaggtgc aggttctcgc      360

ccggattggc tgattgtgga cacctttcat cactgggcgg cggcggcggc ggtggaaaac      420

aaagtgccgt gtgttatgct gctgctgggt gcagcaacgg tgatcgctgg tttcgcgcgt      480

ggtgttagcg aacatgcggc ggcggcggtg ggtaaagaac gtccggctgc ggaagccccg      540

agttttgaaa ccgaacgtcg caagctgatg accacgcaga atgcctccgg catgaccgtg      600

gcagaacgct atttcctgac gctgatgcgt agcgatctgg ttgccatccg ctcttgcgca      660

gaatgggaac cggaaagcgt ggcagcactg accacgctgg caggtaaacc ggtggttccg      720

ctgggtctgc tgccgccgag tccggaaggc ggtcgtggcg tttccaaaga agatgctgcg      780

gtccgttggc tggacgcaca gccggcaaag tcagtcgtgt acgtcgcact gggttcggaa      840

gtgccgctgc gtgcggaaca agttcacgaa ctggcactgg gcctggaact gagcggtgct      900

cgctttctgt gggcgctgcg taaaccgacc gatgcaccgg acgccgcagt gctgccgccg      960

ggtttcgaag aacgtacccg cggccgtggt ctggttgtca cgggttgggt gccgcagatt     1020

ggcgttctgg ctcatggtgc ggtggctgcg tttctgaccc actgtggctg gaactctacg     1080

atcgaaggcc tgctgttcgg tcatccgctg attatgctgc cgatcagctc tgatcagggt     1140

ccgaatgcgc gcctgatgga aggccgtaaa gtcggtatgc aagtgccgcg tgatgaatca     1200

gacggctcgt ttcgtcgcga agatgttgcc gcaaccgtcc gcgccgtggc agttgaagaa     1260

gacggtcgtc gcgtcttcac ggctaacgcg aaaaagatgc aagaaattgt ggccgatggc     1320

gcatgccacg aacgttgtat tgacggtttt atccagcaac tgcgcagtta caaggcgtga     1380


<210>  7
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Ala Asn Ala Glu Arg Met Ile Thr Arg Val His Ser Gln Arg Glu 
1               5                   10                  15      


Arg Leu Asn Glu Thr Leu Val Ser Glu Arg Asn Glu Val Leu Ala Leu 
            20                  25                  30          


Leu Ser Arg Val Glu Ala Lys Gly Lys Gly Ile Leu Gln Gln Asn Gln 
        35                  40                  45              


Ile Ile Ala Glu Phe Glu Ala Leu Pro Glu Gln Thr Arg Lys Lys Leu 
    50                  55                  60                  


Glu Gly Gly Pro Phe Phe Asp Leu Leu Lys Ser Thr Gln Glu Ala Ile 
65                  70                  75                  80  


Val Leu Pro Pro Trp Val Ala Leu Ala Val Arg Pro Arg Pro Gly Val 
                85                  90                  95      


Trp Glu Tyr Leu Arg Val Asn Leu His Ala Leu Val Val Glu Glu Leu 
            100                 105                 110         


Gln Pro Ala Glu Phe Leu His Phe Lys Glu Glu Leu Val Asp Gly Val 
        115                 120                 125             


Lys Asn Gly Asn Phe Thr Leu Glu Leu Asp Phe Glu Pro Phe Asn Ala 
    130                 135                 140                 


Ser Ile Pro Arg Pro Thr Leu His Lys Tyr Ile Gly Asn Gly Val Asp 
145                 150                 155                 160 


Phe Leu Asn Arg His Leu Ser Ala Lys Leu Phe His Asp Lys Glu Ser 
                165                 170                 175     


Leu Leu Pro Leu Leu Lys Phe Leu Arg Leu His Ser His Gln Gly Lys 
            180                 185                 190         


Asn Leu Met Leu Ser Glu Lys Ile Gln Asn Leu Asn Thr Leu Gln His 
        195                 200                 205             


Thr Leu Arg Lys Ala Glu Glu Tyr Leu Ala Glu Leu Lys Ser Glu Thr 
    210                 215                 220                 


Leu Tyr Glu Glu Phe Glu Ala Lys Phe Glu Glu Ile Gly Leu Glu Arg 
225                 230                 235                 240 


Gly Trp Gly Asp Asn Ala Glu Arg Val Leu Asp Met Ile Arg Leu Leu 
                245                 250                 255     


Leu Asp Leu Leu Glu Ala Pro Asp Pro Cys Thr Leu Glu Thr Phe Leu 
            260                 265                 270         


Gly Arg Val Pro Met Val Phe Asn Val Val Ile Leu Ser Pro His Gly 
        275                 280                 285             


Tyr Phe Ala Gln Asp Asn Val Leu Gly Tyr Pro Asp Thr Gly Gly Gln 
    290                 295                 300                 


Val Val Tyr Ile Leu Asp Gln Val Arg Ala Leu Glu Ile Glu Met Leu 
305                 310                 315                 320 


Gln Arg Ile Lys Gln Gln Gly Leu Asn Ile Lys Pro Arg Ile Leu Ile 
                325                 330                 335     


Leu Thr Arg Leu Leu Pro Asp Ala Val Gly Thr Thr Cys Gly Glu Arg 
            340                 345                 350         


Leu Glu Arg Val Tyr Asp Ser Glu Tyr Cys Asp Ile Leu Arg Val Pro 
        355                 360                 365             


Phe Arg Thr Glu Lys Gly Ile Val Arg Lys Trp Ile Ser Arg Phe Glu 
    370                 375                 380                 


Val Trp Pro Tyr Leu Glu Thr Tyr Thr Glu Asp Ala Ala Val Glu Leu 
385                 390                 395                 400 


Ser Lys Glu Leu Asn Gly Lys Pro Asp Leu Ile Ile Gly Asn Tyr Ser 
                405                 410                 415     


Asp Gly Asn Leu Val Ala Ser Leu Leu Ala His Lys Leu Gly Val Thr 
            420                 425                 430         


Gln Cys Thr Ile Ala His Ala Leu Glu Lys Thr Lys Tyr Pro Asp Ser 
        435                 440                 445             


Asp Ile Tyr Trp Lys Lys Leu Asp Asp Lys Tyr His Phe Ser Cys Gln 
    450                 455                 460                 


Phe Thr Ala Asp Ile Phe Ala Met Asn His Thr Asp Phe Ile Ile Thr 
465                 470                 475                 480 


Ser Thr Phe Gln Glu Ile Ala Gly Ser Lys Glu Thr Val Gly Gln Tyr 
                485                 490                 495     


Glu Ser His Thr Ala Phe Thr Leu Pro Gly Leu Tyr Arg Val Val His 
            500                 505                 510         


Gly Ile Asp Val Phe Asp Pro Lys Phe Asn Ile Val Ser Pro Gly Ala 
        515                 520                 525             


Asp Met Ser Ile Tyr Phe Pro Tyr Thr Glu Glu Lys Arg Arg Leu Thr 
    530                 535                 540                 


Lys Phe His Ser Glu Ile Glu Glu Leu Leu Tyr Ser Asp Val Glu Asn 
545                 550                 555                 560 


Lys Glu His Leu Cys Val Leu Lys Asp Lys Lys Lys Pro Ile Leu Phe 
                565                 570                 575     


Thr Met Ala Arg Leu Asp Arg Val Lys Asn Leu Ser Gly Leu Val Glu 
            580                 585                 590         


Trp Tyr Gly Lys Asn Thr Arg Leu Arg Glu Leu Ala Asn Leu Val Val 
        595                 600                 605             


Val Gly Gly Asp Arg Arg Lys Glu Ser Lys Asp Asn Glu Glu Lys Ala 
    610                 615                 620                 


Glu Met Lys Lys Met Tyr Asp Leu Ile Glu Glu Tyr Lys Leu Asn Gly 
625                 630                 635                 640 


Gln Phe Arg Trp Ile Ser Ser Gln Met Asp Arg Val Arg Asn Gly Glu 
                645                 650                 655     


Leu Tyr Arg Tyr Ile Cys Asp Thr Lys Gly Ala Phe Val Gln Pro Ala 
            660                 665                 670         


Leu Tyr Glu Ala Phe Gly Leu Thr Val Val Glu Ala Met Thr Cys Gly 
        675                 680                 685             


Leu Pro Thr Phe Ala Thr Cys Lys Gly Gly Pro Ala Glu Ile Ile Val 
    690                 695                 700                 


His Gly Lys Ser Gly Phe His Ile Asp Pro Tyr His Gly Asp Gln Ala 
705                 710                 715                 720 


Ala Asp Thr Leu Ala Asp Phe Phe Thr Lys Cys Lys Glu Asp Pro Ser 
                725                 730                 735     


His Trp Asp Glu Ile Ser Lys Gly Gly Leu Gln Arg Ile Glu Glu Lys 
            740                 745                 750         


Tyr Thr Trp Gln Ile Tyr Ser Gln Arg Leu Leu Thr Leu Thr Gly Val 
        755                 760                 765             


Tyr Gly Phe Trp Lys His Val Ser Asn Leu Asp Arg Leu Glu Ala Arg 
    770                 775                 780                 


Arg Tyr Leu Glu Met Phe Tyr Ala Leu Lys Tyr Arg Pro Leu Ala Gln 
785                 790                 795                 800 


Ala Val Pro Leu Ala Gln Asp Asp 
                805             


<210>  8
<211>  2427
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
atggcaaacg ctgaacgtat gataacgcgc gtccacagcc aacgtgagcg tttgaacgaa       60

acgcttgttt ctgagagaaa cgaagtcctt gccttgcttt ccagggttga agccaaaggt      120

aaaggtattt tacaacaaaa ccagatcatt gctgaattcg aagctttgcc tgaacaaacc      180

cggaagaaac ttgaaggtgg tcctttcttt gaccttctca aatccactca ggaagcaatt      240

gtgttgccac catgggttgc tctagctgtg aggccaaggc ctggtgtttg ggaatactta      300

cgagtcaatc tccatgctct tgtcgttgaa gaactccaac ctgctgagtt tcttcatttc      360

aaggaagaac tcgttgatgg agttaagaat ggtaatttca ctcttgagct tgatttcgag      420

ccattcaatg cgtctatccc tcgtccaaca ctccacaaat acattggaaa tggtgttgac      480

ttccttaacc gtcatttatc ggctaagctc ttccatgaca aggagagttt gcttccattg      540

cttaagttcc ttcgtcttca cagccaccag ggcaagaacc tgatgttgag cgagaagatt      600

cagaacctca acactctgca acacaccttg aggaaagcag aagagtatct agcagagctt      660

aagtccgaaa cactgtatga agagtttgag gccaagtttg aggagattgg tcttgagagg      720

ggatggggag acaatgcaga gcgtgtcctt gacatgatac gtcttctttt ggaccttctt      780

gaggcgcctg atccttgcac tcttgagact tttcttggaa gagtaccaat ggtgttcaac      840

gttgtgatcc tctctccaca tggttacttt gctcaggaca atgttcttgg ttaccctgac      900

actggtggac aggttgttta cattcttgat caagttcgtg ctctggagat agagatgctt      960

caacgtatta agcaacaagg actcaacatt aaaccaagga ttctcattct aactcgactt     1020

ctacctgatg cggtaggaac tacatgcggt gaacgtctcg agagagttta tgattctgag     1080

tactgtgata ttcttcgtgt gcccttcaga acagagaagg gtattgttcg caaatggatc     1140

tcaaggttcg aagtctggcc atatctagag acttacaccg aggatgctgc ggttgagcta     1200

tcgaaagaat tgaatggcaa gcctgacctt atcattggta actacagtga tggaaatctt     1260

gttgcttctt tattggctca caaacttggt gtcactcagt gtaccattgc tcatgctctt     1320

gagaaaacaa agtacccgga ttctgatatc tactggaaga agcttgacga caagtaccat     1380

ttctcatgcc agttcactgc ggatattttc gcaatgaacc acactgattt catcatcact     1440

agtactttcc aagaaattgc tggaagcaaa gaaactgttg ggcagtatga aagccacaca     1500

gcctttactc ttcccggatt gtatcgagtt gttcacggga ttgatgtgtt tgatcccaag     1560

ttcaacattg tctctcctgg tgctgatatg agcatctact tcccttacac agaggagaag     1620

cgtagattga ctaagttcca ctctgagatc gaggagctcc tctacagcga tgttgagaac     1680

aaagagcact tatgtgtgct caaggacaag aagaagccga ttctcttcac aatggctagg     1740

cttgatcgtg tcaagaactt gtcaggtctt gttgagtggt acgggaagaa cacccgcttg     1800

cgtgagctag ctaacttggt tgttgttgga ggagacagga ggaaagagtc aaaggacaat     1860

gaagagaaag cagagatgaa gaaaatgtat gatctcattg aggaatacaa gctaaacggt     1920

cagttcaggt ggatctcctc tcagatggac cgggtaagga acggtgagct gtaccggtac     1980

atctgtgaca ccaagggtgc ttttgtccaa cctgcattat atgaagcctt tgggttaact     2040

gttgtggagg ctatgacttg tggtttaccg actttcgcca cttgcaaagg tggtccagct     2100

gagatcattg tgcacggtaa atcgggtttc cacattgacc cttaccatgg tgatcaggct     2160

gctgatactc ttgctgattt cttcaccaag tgtaaggagg atccatctca ctgggatgag     2220

atctcaaaag gagggcttca gaggattgag gagaaataca cttggcaaat ctattcacag     2280

aggctcttga cattgactgg tgtgtatgga ttctggaagc atgtctcgaa ccttgaccgt     2340

cttgaggctc gccgttacct tgaaatgttc tatgcattga agtatcgccc attggctcag     2400

gctgttcctc ttgcacaaga tgattga                                         2427


<210>  9
<211>  1268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Glu Asn Lys Thr Glu Thr Thr Val Arg Arg Arg Arg Arg Ile Ile 
1               5                   10                  15      


Leu Phe Pro Val Pro Phe Gln Gly His Ile Asn Pro Ile Leu Gln Leu 
            20                  25                  30          


Ala Asn Val Leu Tyr Ser Lys Gly Phe Ser Ile Thr Ile Phe His Thr 
        35                  40                  45              


Asn Phe Asn Lys Pro Lys Thr Ser Asn Tyr Pro His Phe Thr Phe Arg 
    50                  55                  60                  


Phe Ile Leu Asp Asn Asp Pro Gln Asp Glu Arg Ile Ser Asn Leu Pro 
65                  70                  75                  80  


Thr His Gly Pro Leu Ala Gly Met Arg Ile Pro Ile Ile Asn Glu His 
                85                  90                  95      


Gly Ala Asp Glu Leu Arg Arg Glu Leu Glu Leu Leu Met Leu Ala Ser 
            100                 105                 110         


Glu Glu Asp Glu Glu Val Ser Cys Leu Ile Thr Asp Ala Leu Trp Tyr 
        115                 120                 125             


Phe Ala Gln Ser Val Ala Asp Ser Leu Asn Leu Arg Arg Leu Val Leu 
    130                 135                 140                 


Met Thr Ser Ser Leu Phe Asn Phe His Ala His Val Ser Leu Pro Gln 
145                 150                 155                 160 


Phe Asp Glu Leu Gly Tyr Leu Asp Pro Asp Asp Lys Thr Arg Leu Glu 
                165                 170                 175     


Glu Gln Ala Ser Gly Phe Pro Met Leu Lys Val Lys Asp Ile Lys Ser 
            180                 185                 190         


Ala Tyr Ser Asn Trp Gln Ile Leu Lys Glu Ile Leu Gly Lys Met Ile 
        195                 200                 205             


Lys Gln Thr Lys Ala Ser Ser Gly Val Ile Trp Asn Ser Phe Lys Glu 
    210                 215                 220                 


Leu Glu Glu Ser Glu Leu Glu Thr Val Ile Arg Glu Ile Pro Ala Pro 
225                 230                 235                 240 


Ser Phe Leu Ile Pro Leu Pro Lys His Leu Thr Ala Ser Ser Ser Ser 
                245                 250                 255     


Leu Leu Asp His Asp Arg Thr Val Phe Gln Trp Leu Asp Gln Gln Pro 
            260                 265                 270         


Pro Ser Ser Val Leu Tyr Val Ser Phe Gly Ser Thr Ser Glu Val Asp 
        275                 280                 285             


Glu Lys Asp Phe Leu Glu Ile Ala Arg Gly Leu Val Asp Ser Lys Gln 
    290                 295                 300                 


Ser Phe Leu Trp Val Val Arg Pro Gly Phe Val Lys Gly Ser Thr Trp 
305                 310                 315                 320 


Val Glu Pro Leu Pro Asp Gly Phe Leu Gly Glu Arg Gly Arg Ile Val 
                325                 330                 335     


Lys Trp Val Pro Gln Gln Glu Val Leu Ala His Gly Ala Ile Gly Ala 
            340                 345                 350         


Phe Trp Thr His Ser Gly Trp Asn Ser Thr Leu Glu Ser Val Cys Glu 
        355                 360                 365             


Gly Val Pro Met Ile Phe Ser Asp Phe Gly Leu Asp Gln Pro Leu Asn 
    370                 375                 380                 


Ala Arg Tyr Met Ser Asp Val Leu Lys Val Gly Val Tyr Leu Glu Asn 
385                 390                 395                 400 


Gly Trp Glu Arg Gly Glu Ile Ala Asn Ala Ile Arg Arg Val Met Val 
                405                 410                 415     


Asp Glu Glu Gly Glu Tyr Ile Arg Gln Asn Ala Arg Val Leu Lys Gln 
            420                 425                 430         


Lys Ala Asp Val Ser Leu Met Lys Gly Gly Ser Ser Tyr Glu Ser Leu 
        435                 440                 445             


Glu Ser Leu Val Ser Tyr Ile Ser Ser Leu Gly Ser Gly Ala Asn Ala 
    450                 455                 460                 


Glu Arg Met Ile Thr Arg Val His Ser Gln Arg Glu Arg Leu Asn Glu 
465                 470                 475                 480 


Thr Leu Val Ser Glu Arg Asn Glu Val Leu Ala Leu Leu Ser Arg Val 
                485                 490                 495     


Glu Ala Lys Gly Lys Gly Ile Leu Gln Gln Asn Gln Ile Ile Ala Glu 
            500                 505                 510         


Phe Glu Ala Leu Pro Glu Gln Thr Arg Lys Lys Leu Glu Gly Gly Pro 
        515                 520                 525             


Phe Phe Asp Leu Leu Lys Ser Thr Gln Glu Ala Ile Val Leu Pro Pro 
    530                 535                 540                 


Trp Val Ala Leu Ala Val Arg Pro Arg Pro Gly Val Trp Glu Tyr Leu 
545                 550                 555                 560 


Arg Val Asn Leu His Ala Leu Val Val Glu Glu Leu Gln Pro Ala Glu 
                565                 570                 575     


Phe Leu His Phe Lys Glu Glu Leu Val Asp Gly Val Lys Asn Gly Asn 
            580                 585                 590         


Phe Thr Leu Glu Leu Asp Phe Glu Pro Phe Asn Ala Ser Ile Pro Arg 
        595                 600                 605             


Pro Thr Leu His Lys Tyr Ile Gly Asn Gly Val Asp Phe Leu Asn Arg 
    610                 615                 620                 


His Leu Ser Ala Lys Leu Phe His Asp Lys Glu Ser Leu Leu Pro Leu 
625                 630                 635                 640 


Leu Lys Phe Leu Arg Leu His Ser His Gln Gly Lys Asn Leu Met Leu 
                645                 650                 655     


Ser Glu Lys Ile Gln Asn Leu Asn Thr Leu Gln His Thr Leu Arg Lys 
            660                 665                 670         


Ala Glu Glu Tyr Leu Ala Glu Leu Lys Ser Glu Thr Leu Tyr Glu Glu 
        675                 680                 685             


Phe Glu Ala Lys Phe Glu Glu Ile Gly Leu Glu Arg Gly Trp Gly Asp 
    690                 695                 700                 


Asn Ala Glu Arg Val Leu Asp Met Ile Arg Leu Leu Leu Asp Leu Leu 
705                 710                 715                 720 


Glu Ala Pro Asp Pro Cys Thr Leu Glu Thr Phe Leu Gly Arg Val Pro 
                725                 730                 735     


Met Val Phe Asn Val Val Ile Leu Ser Pro His Gly Tyr Phe Ala Gln 
            740                 745                 750         


Asp Asn Val Leu Gly Tyr Pro Asp Thr Gly Gly Gln Val Val Tyr Ile 
        755                 760                 765             


Leu Asp Gln Val Arg Ala Leu Glu Ile Glu Met Leu Gln Arg Ile Lys 
    770                 775                 780                 


Gln Gln Gly Leu Asn Ile Lys Pro Arg Ile Leu Ile Leu Thr Arg Leu 
785                 790                 795                 800 


Leu Pro Asp Ala Val Gly Thr Thr Cys Gly Glu Arg Leu Glu Arg Val 
                805                 810                 815     


Tyr Asp Ser Glu Tyr Cys Asp Ile Leu Arg Val Pro Phe Arg Thr Glu 
            820                 825                 830         


Lys Gly Ile Val Arg Lys Trp Ile Ser Arg Phe Glu Val Trp Pro Tyr 
        835                 840                 845             


Leu Glu Thr Tyr Thr Glu Asp Ala Ala Val Glu Leu Ser Lys Glu Leu 
    850                 855                 860                 


Asn Gly Lys Pro Asp Leu Ile Ile Gly Asn Tyr Ser Asp Gly Asn Leu 
865                 870                 875                 880 


Val Ala Ser Leu Leu Ala His Lys Leu Gly Val Thr Gln Cys Thr Ile 
                885                 890                 895     


Ala His Ala Leu Glu Lys Thr Lys Tyr Pro Asp Ser Asp Ile Tyr Trp 
            900                 905                 910         


Lys Lys Leu Asp Asp Lys Tyr His Phe Ser Cys Gln Phe Thr Ala Asp 
        915                 920                 925             


Ile Phe Ala Met Asn His Thr Asp Phe Ile Ile Thr Ser Thr Phe Gln 
    930                 935                 940                 


Glu Ile Ala Gly Ser Lys Glu Thr Val Gly Gln Tyr Glu Ser His Thr 
945                 950                 955                 960 


Ala Phe Thr Leu Pro Gly Leu Tyr Arg Val Val His Gly Ile Asp Val 
                965                 970                 975     


Phe Asp Pro Lys Phe Asn Ile Val Ser Pro Gly Ala Asp Met Ser Ile 
            980                 985                 990         


Tyr Phe Pro Tyr Thr Glu Glu Lys  Arg Arg Leu Thr Lys  Phe His Ser 
        995                 1000                 1005             


Glu Ile  Glu Glu Leu Leu Tyr  Ser Asp Val Glu Asn  Lys Glu His 
    1010                 1015                 1020             


Leu Cys  Val Leu Lys Asp Lys  Lys Lys Pro Ile Leu  Phe Thr Met 
    1025                 1030                 1035             


Ala Arg  Leu Asp Arg Val Lys  Asn Leu Ser Gly Leu  Val Glu Trp 
    1040                 1045                 1050             


Tyr Gly  Lys Asn Thr Arg Leu  Arg Glu Leu Ala Asn  Leu Val Val 
    1055                 1060                 1065             


Val Gly  Gly Asp Arg Arg Lys  Glu Ser Lys Asp Asn  Glu Glu Lys 
    1070                 1075                 1080             


Ala Glu  Met Lys Lys Met Tyr  Asp Leu Ile Glu Glu  Tyr Lys Leu 
    1085                 1090                 1095             


Asn Gly  Gln Phe Arg Trp Ile  Ser Ser Gln Met Asp  Arg Val Arg 
    1100                 1105                 1110             


Asn Gly  Glu Leu Tyr Arg Tyr  Ile Cys Asp Thr Lys  Gly Ala Phe 
    1115                 1120                 1125             


Val Gln  Pro Ala Leu Tyr Glu  Ala Phe Gly Leu Thr  Val Val Glu 
    1130                 1135                 1140             


Ala Met  Thr Cys Gly Leu Pro  Thr Phe Ala Thr Cys  Lys Gly Gly 
    1145                 1150                 1155             


Pro Ala  Glu Ile Ile Val His  Gly Lys Ser Gly Phe  His Ile Asp 
    1160                 1165                 1170             


Pro Tyr  His Gly Asp Gln Ala  Ala Asp Thr Leu Ala  Asp Phe Phe 
    1175                 1180                 1185             


Thr Lys  Cys Lys Glu Asp Pro  Ser His Trp Asp Glu  Ile Ser Lys 
    1190                 1195                 1200             


Gly Gly  Leu Gln Arg Ile Glu  Glu Lys Tyr Thr Trp  Gln Ile Tyr 
    1205                 1210                 1215             


Ser Gln  Arg Leu Leu Thr Leu  Thr Gly Val Tyr Gly  Phe Trp Lys 
    1220                 1225                 1230             


His Val  Ser Asn Leu Asp Arg  Leu Glu Ala Arg Arg  Tyr Leu Glu 
    1235                 1240                 1245             


Met Phe  Tyr Ala Leu Lys Tyr  Arg Pro Leu Ala Gln  Ala Val Pro 
    1250                 1255                 1260             


Leu Ala  Gln Asp Asp 
    1265             


<210>  10
<211>  3807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
atggagaata agacagaaac aaccgtaaga cggaggcgga ggattatctt gttccctgta       60

ccatttcagg gccatattaa tccgatcctc caattagcaa acgtcctcta ctccaaggga      120

ttttcaataa caatcttcca tactaacttt aacaagccta aaacgagtaa ttatcctcac      180

tttacattca ggttcattct agacaacgac cctcaggatg agcgtatctc aaatttacct      240

acgcatggcc ccttggcagg tatgcgaata ccaataatca atgagcatgg agccgatgaa      300

ctccgtcgcg agttagagct tctcatgctc gcaagtgagg aagacgagga agtttcgtgc      360

ctaataactg atgcgctttg gtacttcgcc caatcagtcg cagactcact gaatctacgc      420

cgtttggtcc ttatgacaag ttcattattc aactttcacg cacatgtatc actgccgcaa      480

tttgacgagt tgggttacct ggacccggat gacaaaacgc gattggagga acaagcgtcg      540

ggcttcccca tgctgaaagt caaagatatt aagagcgctt atagtaattg gcaaattctg      600

aaagaaattc tcggaaaaat gataaagcaa accaaagcgt cctctggagt aatctggaac      660

tccttcaagg agttagagga atctgaactt gaaacggtca tcagagaaat ccccgctccc      720

tcgttcttaa ttccactacc caagcacctt actgcaagta gcagttccct cctagatcat      780

gaccgaaccg tgtttcagtg gctggatcag caacccccgt cgtcagttct atatgtaagc      840

tttgggagta cttcggaagt ggatgaaaag gacttcttag agattgcgcg agggctcgtg      900

gatagcaaac agagcttcct gtgggtagtg agaccgggat tcgttaaggg ctcgacgtgg      960

gtcgagccgt tgccagatgg ttttctaggg gagagaggga gaatcgtgaa atgggttcca     1020

cagcaagagg ttttggctca cggagctata ggggcctttt ggacccactc tggttggaat     1080

tctactcttg aaagtgtctg tgaaggcgtt ccaatgatat tttctgattt tgggcttgac     1140

cagcctctaa acgctcgcta tatgtctgat gtgttgaagg ttggcgtgta cctggagaat     1200

ggttgggaaa ggggggaaat tgccaacgcc atacgccggg taatggtgga cgaggaaggt     1260

gagtacatac gtcagaacgc tcgggtttta aaacaaaaag cggacgtcag ccttatgaag     1320

ggaggtagct cctatgaatc cctagaatcc ttggtaagct atatatcttc gttaggttct     1380

ggtgcaaacg ctgaacgtat gataacgcgc gtccacagcc aacgtgagcg tttgaacgaa     1440

acgcttgttt ctgagagaaa cgaagtcctt gccttgcttt ccagggttga agccaaaggt     1500

aaaggtattt tacaacaaaa ccagatcatt gctgaattcg aagctttgcc tgaacaaacc     1560

cggaagaaac ttgaaggtgg tcctttcttt gaccttctca aatccactca ggaagcaatt     1620

gtgttgccac catgggttgc tctagctgtg aggccaaggc ctggtgtttg ggaatactta     1680

cgagtcaatc tccatgctct tgtcgttgaa gaactccaac ctgctgagtt tcttcatttc     1740

aaggaagaac tcgttgatgg agttaagaat ggtaatttca ctcttgagct tgatttcgag     1800

ccattcaatg cgtctatccc tcgtccaaca ctccacaaat acattggaaa tggtgttgac     1860

ttccttaacc gtcatttatc ggctaagctc ttccatgaca aggagagttt gcttccattg     1920

cttaagttcc ttcgtcttca cagccaccag ggcaagaacc tgatgttgag cgagaagatt     1980

cagaacctca acactctgca acacaccttg aggaaagcag aagagtatct agcagagctt     2040

aagtccgaaa cactgtatga agagtttgag gccaagtttg aggagattgg tcttgagagg     2100

ggatggggag acaatgcaga gcgtgtcctt gacatgatac gtcttctttt ggaccttctt     2160

gaggcgcctg atccttgcac tcttgagact tttcttggaa gagtaccaat ggtgttcaac     2220

gttgtgatcc tctctccaca tggttacttt gctcaggaca atgttcttgg ttaccctgac     2280

actggtggac aggttgttta cattcttgat caagttcgtg ctctggagat agagatgctt     2340

caacgtatta agcaacaagg actcaacatt aaaccaagga ttctcattct aactcgactt     2400

ctacctgatg cggtaggaac tacatgcggt gaacgtctcg agagagttta tgattctgag     2460

tactgtgata ttcttcgtgt gcccttcaga acagagaagg gtattgttcg caaatggatc     2520

tcaaggttcg aagtctggcc atatctagag acttacaccg aggatgctgc ggttgagcta     2580

tcgaaagaat tgaatggcaa gcctgacctt atcattggta actacagtga tggaaatctt     2640

gttgcttctt tattggctca caaacttggt gtcactcagt gtaccattgc tcatgctctt     2700

gagaaaacaa agtacccgga ttctgatatc tactggaaga agcttgacga caagtaccat     2760

ttctcatgcc agttcactgc ggatattttc gcaatgaacc acactgattt catcatcact     2820

agtactttcc aagaaattgc tggaagcaaa gaaactgttg ggcagtatga aagccacaca     2880

gcctttactc ttcccggatt gtatcgagtt gttcacggga ttgatgtgtt tgatcccaag     2940

ttcaacattg tctctcctgg tgctgatatg agcatctact tcccttacac agaggagaag     3000

cgtagattga ctaagttcca ctctgagatc gaggagctcc tctacagcga tgttgagaac     3060

aaagagcact tatgtgtgct caaggacaag aagaagccga ttctcttcac aatggctagg     3120

cttgatcgtg tcaagaactt gtcaggtctt gttgagtggt acgggaagaa cacccgcttg     3180

cgtgagctag ctaacttggt tgttgttgga ggagacagga ggaaagagtc aaaggacaat     3240

gaagagaaag cagagatgaa gaaaatgtat gatctcattg aggaatacaa gctaaacggt     3300

cagttcaggt ggatctcctc tcagatggac cgggtaagga acggtgagct gtaccggtac     3360

atctgtgaca ccaagggtgc ttttgtccaa cctgcattat atgaagcctt tgggttaact     3420

gttgtggagg ctatgacttg tggtttaccg actttcgcca cttgcaaagg tggtccagct     3480

gagatcattg tgcacggtaa atcgggtttc cacattgacc cttaccatgg tgatcaggct     3540

gctgatactc ttgctgattt cttcaccaag tgtaaggagg atccatctca ctgggatgag     3600

atctcaaaag gagggcttca gaggattgag gagaaataca cttggcaaat ctattcacag     3660

aggctcttga cattgactgg tgtgtatgga ttctggaagc atgtctcgaa ccttgaccgt     3720

cttgaggctc gccgttacct tgaaatgttc tatgcattga agtatcgccc attggctcag     3780

gctgttcctc ttgcacaaga tgattga                                         3807


<210>  11
<211>  1272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Asp Ser Gly Tyr Ser Ser Ser Tyr Ala Ala Ala Ala Gly Met His 
1               5                   10                  15      


Val Val Ile Cys Pro Trp Leu Ala Phe Gly His Leu Leu Pro Cys Leu 
            20                  25                  30          


Asp Leu Ala Gln Arg Leu Ala Ser Arg Gly His Arg Val Ser Phe Val 
        35                  40                  45              


Ser Thr Pro Arg Asn Ile Ser Arg Leu Pro Pro Val Arg Pro Ala Leu 
    50                  55                  60                  


Ala Pro Leu Val Ala Phe Val Ala Leu Pro Leu Pro Arg Val Glu Gly 
65                  70                  75                  80  


Leu Pro Asp Gly Ala Glu Ser Thr Asn Asp Val Pro His Asp Arg Pro 
                85                  90                  95      


Asp Met Val Glu Leu His Arg Arg Ala Phe Asp Gly Leu Ala Ala Pro 
            100                 105                 110         


Phe Ser Glu Phe Leu Gly Thr Ala Cys Ala Asp Trp Val Ile Val Asp 
        115                 120                 125             


Val Phe His His Trp Ala Ala Ala Ala Ala Leu Glu His Lys Val Pro 
    130                 135                 140                 


Cys Ala Met Met Leu Leu Gly Ser Ala His Met Ile Ala Ser Ile Ala 
145                 150                 155                 160 


Asp Arg Arg Leu Glu Arg Ala Glu Thr Glu Ser Pro Ala Ala Ala Gly 
                165                 170                 175     


Gln Gly Arg Pro Ala Ala Ala Pro Thr Phe Glu Val Ala Arg Met Lys 
            180                 185                 190         


Leu Ile Arg Thr Lys Gly Ser Ser Gly Met Ser Leu Ala Glu Arg Phe 
        195                 200                 205             


Ser Leu Thr Leu Ser Arg Ser Ser Leu Val Val Gly Arg Ser Cys Val 
    210                 215                 220                 


Glu Phe Glu Pro Glu Thr Val Pro Leu Leu Ser Thr Leu Arg Gly Lys 
225                 230                 235                 240 


Pro Ile Thr Phe Leu Gly Leu Met Pro Pro Leu His Glu Gly Arg Arg 
                245                 250                 255     


Glu Asp Gly Glu Asp Ala Thr Val Arg Trp Leu Asp Ala Gln Pro Ala 
            260                 265                 270         


Lys Ser Val Val Tyr Val Ala Leu Gly Ser Glu Val Pro Leu Gly Val 
        275                 280                 285             


Glu Lys Val His Glu Leu Ala Leu Gly Leu Glu Leu Ala Gly Thr Arg 
    290                 295                 300                 


Phe Leu Trp Ala Leu Arg Lys Pro Thr Gly Val Ser Asp Ala Asp Leu 
305                 310                 315                 320 


Leu Pro Ala Gly Phe Glu Glu Arg Thr Arg Gly Arg Gly Val Val Ala 
                325                 330                 335     


Thr Arg Trp Val Pro Gln Met Ser Ile Leu Ala His Ala Ala Val Gly 
            340                 345                 350         


Ala Phe Leu Thr His Cys Gly Trp Asn Ser Thr Ile Glu Gly Leu Met 
        355                 360                 365             


Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Gly Asp Gln Gly Pro 
    370                 375                 380                 


Asn Ala Arg Leu Ile Glu Ala Lys Asn Ala Gly Leu Gln Val Ala Arg 
385                 390                 395                 400 


Asn Asp Gly Asp Gly Ser Phe Asp Arg Glu Gly Val Ala Ala Ala Ile 
                405                 410                 415     


Arg Ala Val Ala Val Glu Glu Glu Ser Ser Lys Val Phe Gln Ala Lys 
            420                 425                 430         


Ala Lys Lys Leu Gln Glu Ile Val Ala Asp Met Ala Cys His Glu Arg 
        435                 440                 445             


Tyr Ile Asp Gly Phe Ile Gln Gln Leu Arg Ser Tyr Lys Asp Gly Ser 
    450                 455                 460                 


Gly Ala Asn Ala Glu Arg Met Ile Thr Arg Val His Ser Gln Arg Glu 
465                 470                 475                 480 


Arg Leu Asn Glu Thr Leu Val Ser Glu Arg Asn Glu Val Leu Ala Leu 
                485                 490                 495     


Leu Ser Arg Val Glu Ala Lys Gly Lys Gly Ile Leu Gln Gln Asn Gln 
            500                 505                 510         


Ile Ile Ala Glu Phe Glu Ala Leu Pro Glu Gln Thr Arg Lys Lys Leu 
        515                 520                 525             


Glu Gly Gly Pro Phe Phe Asp Leu Leu Lys Ser Thr Gln Glu Ala Ile 
    530                 535                 540                 


Val Leu Pro Pro Trp Val Ala Leu Ala Val Arg Pro Arg Pro Gly Val 
545                 550                 555                 560 


Trp Glu Tyr Leu Arg Val Asn Leu His Ala Leu Val Val Glu Glu Leu 
                565                 570                 575     


Gln Pro Ala Glu Phe Leu His Phe Lys Glu Glu Leu Val Asp Gly Val 
            580                 585                 590         


Lys Asn Gly Asn Phe Thr Leu Glu Leu Asp Phe Glu Pro Phe Asn Ala 
        595                 600                 605             


Ser Ile Pro Arg Pro Thr Leu His Lys Tyr Ile Gly Asn Gly Val Asp 
    610                 615                 620                 


Phe Leu Asn Arg His Leu Ser Ala Lys Leu Phe His Asp Lys Glu Ser 
625                 630                 635                 640 


Leu Leu Pro Leu Leu Lys Phe Leu Arg Leu His Ser His Gln Gly Lys 
                645                 650                 655     


Asn Leu Met Leu Ser Glu Lys Ile Gln Asn Leu Asn Thr Leu Gln His 
            660                 665                 670         


Thr Leu Arg Lys Ala Glu Glu Tyr Leu Ala Glu Leu Lys Ser Glu Thr 
        675                 680                 685             


Leu Tyr Glu Glu Phe Glu Ala Lys Phe Glu Glu Ile Gly Leu Glu Arg 
    690                 695                 700                 


Gly Trp Gly Asp Asn Ala Glu Arg Val Leu Asp Met Ile Arg Leu Leu 
705                 710                 715                 720 


Leu Asp Leu Leu Glu Ala Pro Asp Pro Cys Thr Leu Glu Thr Phe Leu 
                725                 730                 735     


Gly Arg Val Pro Met Val Phe Asn Val Val Ile Leu Ser Pro His Gly 
            740                 745                 750         


Tyr Phe Ala Gln Asp Asn Val Leu Gly Tyr Pro Asp Thr Gly Gly Gln 
        755                 760                 765             


Val Val Tyr Ile Leu Asp Gln Val Arg Ala Leu Glu Ile Glu Met Leu 
    770                 775                 780                 


Gln Arg Ile Lys Gln Gln Gly Leu Asn Ile Lys Pro Arg Ile Leu Ile 
785                 790                 795                 800 


Leu Thr Arg Leu Leu Pro Asp Ala Val Gly Thr Thr Cys Gly Glu Arg 
                805                 810                 815     


Leu Glu Arg Val Tyr Asp Ser Glu Tyr Cys Asp Ile Leu Arg Val Pro 
            820                 825                 830         


Phe Arg Thr Glu Lys Gly Ile Val Arg Lys Trp Ile Ser Arg Phe Glu 
        835                 840                 845             


Val Trp Pro Tyr Leu Glu Thr Tyr Thr Glu Asp Ala Ala Val Glu Leu 
    850                 855                 860                 


Ser Lys Glu Leu Asn Gly Lys Pro Asp Leu Ile Ile Gly Asn Tyr Ser 
865                 870                 875                 880 


Asp Gly Asn Leu Val Ala Ser Leu Leu Ala His Lys Leu Gly Val Thr 
                885                 890                 895     


Gln Cys Thr Ile Ala His Ala Leu Glu Lys Thr Lys Tyr Pro Asp Ser 
            900                 905                 910         


Asp Ile Tyr Trp Lys Lys Leu Asp Asp Lys Tyr His Phe Ser Cys Gln 
        915                 920                 925             


Phe Thr Ala Asp Ile Phe Ala Met Asn His Thr Asp Phe Ile Ile Thr 
    930                 935                 940                 


Ser Thr Phe Gln Glu Ile Ala Gly Ser Lys Glu Thr Val Gly Gln Tyr 
945                 950                 955                 960 


Glu Ser His Thr Ala Phe Thr Leu Pro Gly Leu Tyr Arg Val Val His 
                965                 970                 975     


Gly Ile Asp Val Phe Asp Pro Lys Phe Asn Ile Val Ser Pro Gly Ala 
            980                 985                 990         


Asp Met Ser Ile Tyr Phe Pro Tyr  Thr Glu Glu Lys Arg  Arg Leu Thr 
        995                 1000                 1005             


Lys Phe  His Ser Glu Ile Glu  Glu Leu Leu Tyr Ser  Asp Val Glu 
    1010                 1015                 1020             


Asn Lys  Glu His Leu Cys Val  Leu Lys Asp Lys Lys  Lys Pro Ile 
    1025                 1030                 1035             


Leu Phe  Thr Met Ala Arg Leu  Asp Arg Val Lys Asn  Leu Ser Gly 
    1040                 1045                 1050             


Leu Val  Glu Trp Tyr Gly Lys  Asn Thr Arg Leu Arg  Glu Leu Ala 
    1055                 1060                 1065             


Asn Leu  Val Val Val Gly Gly  Asp Arg Arg Lys Glu  Ser Lys Asp 
    1070                 1075                 1080             


Asn Glu  Glu Lys Ala Glu Met  Lys Lys Met Tyr Asp  Leu Ile Glu 
    1085                 1090                 1095             


Glu Tyr  Lys Leu Asn Gly Gln  Phe Arg Trp Ile Ser  Ser Gln Met 
    1100                 1105                 1110             


Asp Arg  Val Arg Asn Gly Glu  Leu Tyr Arg Tyr Ile  Cys Asp Thr 
    1115                 1120                 1125             


Lys Gly  Ala Phe Val Gln Pro  Ala Leu Tyr Glu Ala  Phe Gly Leu 
    1130                 1135                 1140             


Thr Val  Val Glu Ala Met Thr  Cys Gly Leu Pro Thr  Phe Ala Thr 
    1145                 1150                 1155             


Cys Lys  Gly Gly Pro Ala Glu  Ile Ile Val His Gly  Lys Ser Gly 
    1160                 1165                 1170             


Phe His  Ile Asp Pro Tyr His  Gly Asp Gln Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Ala Asp  Phe Phe Thr Lys Cys  Lys Glu Asp Pro Ser  His Trp Asp 
    1190                 1195                 1200             


Glu Ile  Ser Lys Gly Gly Leu  Gln Arg Ile Glu Glu  Lys Tyr Thr 
    1205                 1210                 1215             


Trp Gln  Ile Tyr Ser Gln Arg  Leu Leu Thr Leu Thr  Gly Val Tyr 
    1220                 1225                 1230             


Gly Phe  Trp Lys His Val Ser  Asn Leu Asp Arg Leu  Glu Ala Arg 
    1235                 1240                 1245             


Arg Tyr  Leu Glu Met Phe Tyr  Ala Leu Lys Tyr Arg  Pro Leu Ala 
    1250                 1255                 1260             


Gln Ala  Val Pro Leu Ala Gln  Asp Asp 
    1265                 1270         


<210>  12
<211>  3819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
atggattcgg gttactcttc ctcctatgcg gcggctgcgg gtatgcacgt tgttatctgt       60

ccgtggctgg cttttggtca cctgctgccg tgcctggatc tggcacagcg tctggcttca      120

cgcggccatc gtgtcagctt cgtgtctacc ccgcgcaata tttcgcgtct gccgccggtt      180

cgtccggcac tggctccgct ggttgcattt gtcgctctgc cgctgccgcg cgtggaaggt      240

ctgccggatg gtgcggaaag taccaacgac gtgccgcatg atcgcccgga catggttgaa      300

ctgcaccgtc gtgcattcga tggtctggca gcaccgtttt ccgaatttct gggtacggcg      360

tgcgccgatt gggtgatcgt tgacgtcttt catcactggg cggcggcggc ggcgctggaa      420

cataaagttc cgtgtgcaat gatgctgctg ggctcagctc acatgattgc gtcgatcgca      480

gaccgtcgcc tggaacgtgc agaaaccgaa agtccggctg cggccggcca gggtcgcccg      540

gcagctgcgc cgaccttcga agtggcccgc atgaaactga ttcgtacgaa aggcagctct      600

ggtatgagcc tggcagaacg ctttagtctg accctgtccc gtagttccct ggtggttggt      660

cgcagttgcg ttgaatttga accggaaacc gtcccgctgc tgtccacgct gcgtggtaaa      720

ccgatcacct ttctgggtct gatgccgccg ctgcatgaag gccgtcgcga agatggtgaa      780

gacgcaacgg tgcgttggct ggatgcacag ccggctaaaa gcgtcgtgta tgtcgccctg      840

ggctctgaag tgccgctggg tgtggaaaaa gttcacgaac tggcactggg cctggaactg      900

gctggcaccc gcttcctgtg ggcactgcgt aaaccgacgg gtgtgagcga tgcggacctg      960

ctgccggccg gttttgaaga acgtacccgc ggccgtggtg ttgtcgcaac gcgttgggtc     1020

ccgcaaatga gcattctggc gcatgccgca gtgggcgcct ttctgaccca ctgtggttgg     1080

aacagcacga tcgaaggcct gatgtttggt cacccgctga ttatgctgcc gatcttcggc     1140

gatcagggtc cgaacgcacg tctgattgaa gcgaaaaatg ccggcctgca agttgcgcgc     1200

aacgatggcg acggttcttt cgaccgtgag ggtgtggctg cggccattcg cgcagtggct     1260

gttgaagaag aatcatcgaa agtttttcag gcgaaagcca aaaaactgca agaaatcgtc     1320

gcggatatgg cctgccacga acgctacatt gatggtttca ttcagcaact gcgctcctac     1380

aaagacggtt ctggtgcaaa cgctgaacgt atgataacgc gcgtccacag ccaacgtgag     1440

cgtttgaacg aaacgcttgt ttctgagaga aacgaagtcc ttgccttgct ttccagggtt     1500

gaagccaaag gtaaaggtat tttacaacaa aaccagatca ttgctgaatt cgaagctttg     1560

cctgaacaaa cccggaagaa acttgaaggt ggtcctttct ttgaccttct caaatccact     1620

caggaagcaa ttgtgttgcc accatgggtt gctctagctg tgaggccaag gcctggtgtt     1680

tgggaatact tacgagtcaa tctccatgct cttgtcgttg aagaactcca acctgctgag     1740

tttcttcatt tcaaggaaga actcgttgat ggagttaaga atggtaattt cactcttgag     1800

cttgatttcg agccattcaa tgcgtctatc cctcgtccaa cactccacaa atacattgga     1860

aatggtgttg acttccttaa ccgtcattta tcggctaagc tcttccatga caaggagagt     1920

ttgcttccat tgcttaagtt ccttcgtctt cacagccacc agggcaagaa cctgatgttg     1980

agcgagaaga ttcagaacct caacactctg caacacacct tgaggaaagc agaagagtat     2040

ctagcagagc ttaagtccga aacactgtat gaagagtttg aggccaagtt tgaggagatt     2100

ggtcttgaga ggggatgggg agacaatgca gagcgtgtcc ttgacatgat acgtcttctt     2160

ttggaccttc ttgaggcgcc tgatccttgc actcttgaga cttttcttgg aagagtacca     2220

atggtgttca acgttgtgat cctctctcca catggttact ttgctcagga caatgttctt     2280

ggttaccctg acactggtgg acaggttgtt tacattcttg atcaagttcg tgctctggag     2340

atagagatgc ttcaacgtat taagcaacaa ggactcaaca ttaaaccaag gattctcatt     2400

ctaactcgac ttctacctga tgcggtagga actacatgcg gtgaacgtct cgagagagtt     2460

tatgattctg agtactgtga tattcttcgt gtgcccttca gaacagagaa gggtattgtt     2520

cgcaaatgga tctcaaggtt cgaagtctgg ccatatctag agacttacac cgaggatgct     2580

gcggttgagc tatcgaaaga attgaatggc aagcctgacc ttatcattgg taactacagt     2640

gatggaaatc ttgttgcttc tttattggct cacaaacttg gtgtcactca gtgtaccatt     2700

gctcatgctc ttgagaaaac aaagtacccg gattctgata tctactggaa gaagcttgac     2760

gacaagtacc atttctcatg ccagttcact gcggatattt tcgcaatgaa ccacactgat     2820

ttcatcatca ctagtacttt ccaagaaatt gctggaagca aagaaactgt tgggcagtat     2880

gaaagccaca cagcctttac tcttcccgga ttgtatcgag ttgttcacgg gattgatgtg     2940

tttgatccca agttcaacat tgtctctcct ggtgctgata tgagcatcta cttcccttac     3000

acagaggaga agcgtagatt gactaagttc cactctgaga tcgaggagct cctctacagc     3060

gatgttgaga acaaagagca cttatgtgtg ctcaaggaca agaagaagcc gattctcttc     3120

acaatggcta ggcttgatcg tgtcaagaac ttgtcaggtc ttgttgagtg gtacgggaag     3180

aacacccgct tgcgtgagct agctaacttg gttgttgttg gaggagacag gaggaaagag     3240

tcaaaggaca atgaagagaa agcagagatg aagaaaatgt atgatctcat tgaggaatac     3300

aagctaaacg gtcagttcag gtggatctcc tctcagatgg accgggtaag gaacggtgag     3360

ctgtaccggt acatctgtga caccaagggt gcttttgtcc aacctgcatt atatgaagcc     3420

tttgggttaa ctgttgtgga ggctatgact tgtggtttac cgactttcgc cacttgcaaa     3480

ggtggtccag ctgagatcat tgtgcacggt aaatcgggtt tccacattga cccttaccat     3540

ggtgatcagg ctgctgatac tcttgctgat ttcttcacca agtgtaagga ggatccatct     3600

cactgggatg agatctcaaa aggagggctt cagaggattg aggagaaata cacttggcaa     3660

atctattcac agaggctctt gacattgact ggtgtgtatg gattctggaa gcatgtctcg     3720

aaccttgacc gtcttgaggc tcgccgttac cttgaaatgt tctatgcatt gaagtatcgc     3780

ccattggctc aggctgttcc tcttgcacaa gatgattga                            3819


