                         SEQUENCE LISTING

<110>  VERTEX PHARAMCEUTICALS, INC.
 
<120>  INFLUENZA A VIRUS VARIANTS

<130>  223306/14-105PRV1/355617

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  759
<212>  PRT
<213>  Influenza A virus

<400>  1

Met Glu Arg Ile Lys Glu Leu Arg Asn Leu Met Ser Gln Ser Arg Thr 
1               5                   10                  15      


Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          


Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              


Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Thr 
    50                  55                  60                  


Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  


Met Asn Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      


Thr Trp Trp Asn Arg Asn Gly Pro Ile Thr Asn Thr Val His Tyr Pro 
            100                 105                 110         


Lys Ile Tyr Lys Thr Tyr Phe Glu Arg Val Glu Arg Leu Lys His Gly 
        115                 120                 125             


Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 


Val Asp Ile Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 


Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     


Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Glu Glu 
            180                 185                 190         


Leu Gln Asp Cys Lys Ile Ser Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             


Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 


Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 


Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Arg Asn Asp Asp Val Asp 
                245                 250                 255     


Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Ala Val 
            260                 265                 270         


Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             


Ile Gly Gly Ile Arg Met Val Asp Ile Leu Arg Gln Asn Pro Thr Glu 
    290                 295                 300                 


Glu Gln Ala Val Asp Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 


Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     


Ser Val Lys Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         


Lys Ile Arg Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 
        355                 360                 365             


Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 


Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 


Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     


Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         


Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             


Trp Gly Val Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 
    450                 455                 460                 


Pro Asp Met Thr Pro Ser Ile Glu Met Ser Met Arg Gly Val Arg Ile 
465                 470                 475                 480 


Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val 
                485                 490                 495     


Ser Ile Asp Arg Phe Leu Arg Ile Arg Asp Gln Arg Gly Asn Val Leu 
            500                 505                 510         


Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             


Ile Thr Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 


Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Thr Ile 
545                 550                 555                 560 


Lys Ile Gln Trp Ser Gln Asn Pro Thr Met Leu Tyr Asn Lys Met Glu 
                565                 570                 575     


Phe Glu Pro Phe Gln Ser Leu Val Pro Lys Ala Ile Arg Gly Gln Tyr 
            580                 585                 590         


Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             


Thr Phe Asp Thr Ala Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 


Pro Pro Lys Gln Ser Arg Met Gln Phe Ser Ser Phe Thr Val Asn Val 
625                 630                 635                 640 


Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Val Phe 
                645                 650                 655     


Asn Tyr Asn Lys Ala Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 
            660                 665                 670         


Gly Thr Leu Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 
        675                 680                 685             


Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asp Lys Arg Tyr 
    690                 695                 700                 


Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Asn Leu Ala Lys Gly Glu 
705                 710                 715                 720 


Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     


Arg Lys Arg Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         


Arg Ile Arg Met Ala Ile Asn 
        755                 


<210>  2
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sub-Synthetic Oligonucleotide

<400>  2
agcraaagca gg                                                           12


<210>  3
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sub-Synthetic Oligonucleotide


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u

<400>  3
cgtctcnggg agcgaaagca ggtactgatc caaaat                                 36


<210>  4
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sub-Synthetic Oligonucleotide


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u

<400>  4
cgtctcntat tagtagaaac aaggtacttt tttgga                                 36


<210>  5
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sub-Synthetic Oligonucleotide


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u

<400>  5
cgtctcnggg agcgaaagca ggcaaaccat ttgaa                                  35


<210>  6
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sub-Synthetic Oligonucleotide


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u

<400>  6
cgtctcntat tagtaggaac aaggcatttt ttcatg                                 36


<210>  7
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sub-Synthetic Oligonucleotide


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u

<400>  7
cgtctcnggg agcgaaagca ggtcaattat attcaa                                 36


<210>  8
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sub-Synthetic Oligonucleotide


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u

<400>  8
cgtctcntat tagtagaaac aaggtcgttt ttaaac                                 36


