                         SEQUENCE LISTING

<110>  California Institute of Technology
 
<120>  Crosslinked Anti-HIV-1 Compositions for Potent and Broad 
       Neutralization

<130>  78671.WO C766

<140>  PCT/US2015/53371
<141>  2015-09-30

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab 1 ss oligo

<400>  1
tttttttttt ttctttgttc ttattctctg ct                                     32


<210>  2
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  Fab 2 ssoligo

<400>  2
aagagagaga aaaggaagaa gggaagaaga gg                                     32


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10 bp 1 linker

<400>  3
tttttttttt ttggacgaag tc                                                22


<210>  4
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  10bp 2 linker

<400>  4
aagagagaga aagacttcgt cc                                                22


<210>  5
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  15bp 1 linker

<400>  5
tttttttttt ttggacgaag tccaacc                                           27


<210>  6
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  15bp 2 linker

<400>  6
aagagagaga aaggttggac ttcgtcc                                           27


<210>  7
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  20bp 1 linker

<400>  7
tttttttttt ttcgtggtca tgagccggga cg                                     32


<210>  8
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  20bp 2 linker

<400>  8
aagagagaga aacgtcccgg ctcatgacca cg                                     32


<210>  9
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  25bp 1 linker

<400>  9
tttttttttt ttcgtggtca tgagccggga cgaagtc                                37


<210>  10
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  25bp 2 linker

<400>  10
aagagagaga aagacttcgt cccggctcat gaccacg                                37


<210>  11
<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  30bp 1 linker

<400>  11
tttttttttt ttcgtggtca tgagccggga cgaagtccaa cc                          42


<210>  12
<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  30bp 2 linker

<400>  12
aagagagaga aaggttggac ttcgtcccgg ctcatgacca cg                          42


<210>  13
<211>  40
<212>  DNA
<213>  artificial sequence

<220>
<223>  40bp 1 linker

<400>  13
gaggactatc cggcgccgtc cctcttcttc ccttcttcct                             40


<210>  14
<211>  40
<212>  DNA
<213>  artificial sequence

<220>
<223>  40bp 2 linker

<400>  14
gacggcgccg gatagtcctc agcagagaat aagaacaaag                             40


<210>  15
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  50bp 1 linker

<400>  15
tgggcgactc gacggcgccg gatagtcctc agcagagaat aagaacaaag                  50


<210>  16
<211>  50
<212>  DNA
<213>  artificial sequence

<220>
<223>  50bp 2 linker

<400>  16
gaggactatc cggcgccgtc gagtcgccca cctcttcttc ccttcttcct                  50


<210>  17
<211>  40
<212>  DNA
<213>  artificial sequence

<220>
<223>  60bp 1 linker

<400>  17
ttctttcttt cctccttctc cctcttcttc ccttcttcct                             40


<210>  18
<211>  40
<212>  DNA
<213>  artificial sequence

<220>
<223>  60bp 2 linker

<400>  18
gagaaggagg aaagaaagaa agcagagaat aagaacaaag                             40


<210>  19
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  70bp 1 linker

<400>  19
tttttttttt ttcgtggtca tgagccggga cg                                     32


<210>  20
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  70bp 2 linker

<400>  20
agccttactg gtggtgccac tgggcgactc gacggcgccg gatagtcctc agcagagaat       60

aagaacaaag                                                              70


<210>  21
<211>  80
<212>  DNA
<213>  artificial sequence

<220>
<223>  80bp 1 linker

<400>  21
gaggactatc cggcgccgtc gagtcgccca gtggcaccac cagtaaggct tatcgcatgt       60

cctcttcttc ccttcttcct                                                   80


<210>  22
<211>  80
<212>  DNA
<213>  artificial sequence

<220>
<223>  80bp 2 linker

<400>  22
acatgcgata agccttactg gtggtgccac tgggcgactc gacggcgccg gatagtcctc       60

agcagagaat aagaacaaag                                                   80


<210>  23
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90bp 1 linker

<400>  23
gaggactatc cggcgccgtc gagtcgccca gtggcaccac cagtaaggct tatcgcatgt       60

aagttgcacc cctcttcttc ccttcttcct                                        90


<210>  24
<211>  87
<212>  DNA
<213>  artificial sequence

<220>
<223>  90bp 2 linker

<400>  24
ggtgcaactt acatgcgata agccttactg gtggtgccac tgggcgactc gacggcgccg       60

gatagtcctc agcagagaat aagaaca                                           87


<210>  25
<211>  100
<212>  DNA
<213>  artificial sequence

<220>
<223>  100bp 1 linker

<400>  25
gaggactatc cggccccgtc gagtcgccca gtggcaccac cagtaaggct tatcgcatgt       60

aagttgcacc cccatcctcc cctcttcttc ccttcttcct                            100


<210>  26
<211>  100
<212>  DNA
<213>  artificial sequence

<220>
<223>  100bp 2 linker

<400>  26
ggaggatggg ggtgcaactt acatgcgata agccttactg gtggtgccac tgggcgactc       60

gacggggccg gatagtcctc agcagagaat aagaacaaag                            100


<210>  27
<211>  247
<212>  PRT
<213>  homo sapien

<400>  27

Glu Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Leu Ala Ser Gly Phe Thr Phe His Lys Tyr Gly 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Leu Ile Ser Asp Asp Gly Met Arg Lys Tyr His Ser Asp Ser Met Trp 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Phe Ser Ser Leu Lys Val Glu Asp Thr Ala Met Phe Phe Cys Ala 
                85                  90                  95      


Arg Glu Ala Gly Gly Pro Ile Trp His Asp Asp Val Lys Tyr Thr Tyr 
            100                 105                 110         


Ser Asp Phe Asn Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val Trp 
        115                 120                 125             


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Gly Leu Glu Val Leu Phe 
                245         


<210>  28
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ile Thr Ile Ser Cys Gln Gly Thr Ser Ser Asp Val Gly Gly Phe 
            20                  25                  30          


Asp Ser Val Ser Trp Tyr Gln Gln Ser Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Met Val Phe Asp Val Ser His Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


His Ile Glu Asp Glu Gly Asp Tyr Phe Cys Ser Ser Leu Thr Asp Arg 
                85                  90                  95      


Ser His Arg Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  29
<211>  251
<212>  PRT
<213>  homo sapiens

<400>  29

Arg Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Ser Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Gln Gly Met 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Ala Phe 
        35                  40                  45              


Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His Ala Asp Ser Val Trp Gly 
    50                  55                  60                  


Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg 
                85                  90                  95      


Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn Thr Tyr Ser Thr 
            100                 105                 110         


Tyr Ser Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
        115                 120                 125             


Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Gly Leu Glu Val Leu Phe Gln 
                245                 250     


<210>  30
<211>  216
<212>  PRT
<213>  homo sapiens

<400>  30

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Gln Gly Thr Ser Asn Asp Val Gly Gly Tyr 
            20                  25                  30          


Glu Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Val Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Lys Ser Leu Thr Ser Thr 
                85                  90                  95      


Arg Arg Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  31
<211>  229
<212>  PRT
<213>  homo sapiens

<400>  31

Gln Val His Leu Ser Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Lys Ile Ser Asp His 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg Gln Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Tyr Ser Phe Tyr Met Asp Leu Lys Ala Val Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Ile Tyr Phe Cys Ala Arg Gln Arg Ser Asp Phe Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr 
225                 


<210>  32
<211>  206
<212>  PRT
<213>  homo sapiens

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ala Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Val Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Ile Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            100                 105                 110         


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
        115                 120                 125             


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
    130                 135                 140                 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
145                 150                 155                 160 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
                165                 170                 175     


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
            180                 185                 190         


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        195                 200                 205     


<210>  33
<211>  230
<212>  PRT
<213>  homo sapiens

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Gln Ala Ser Gly Tyr Arg Phe Ser Asn Phe 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Asn Gly Asn Lys Glu Phe Ser Ala Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Phe Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Tyr Ser Trp Asp Asp Ser Pro Gln Asp Asn Tyr 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Ile Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Ala Glu Pro Lys Ser Cys 
225                 230 


<210>  34
<211>  215
<212>  PRT
<213>  homo sapiens

<400>  34

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Phe Ser Cys Arg Ser Ser His Ser Ile Arg Ser Arg 
            20                  25                  30          


Arg Val Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Val 
        35                  40                  45              


Ile His Gly Val Ser Asn Arg Ala Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Val Tyr Gly Ala Ser Ser 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Arg Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Arg Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  35
<211>  236
<212>  PRT
<213>  homo sapiens

<400>  35

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Arg Glu Ser Ala Thr Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Val Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235     


<210>  36
<211>  214
<212>  PRT
<213>  homo sapiens

<400>  36

Ser Tyr Val Arg Pro Leu Ser Val Ala Leu Gly Glu Thr Ala Arg Ile 
1               5                   10                  15      


Ser Cys Gly Arg Gln Ala Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln 
            20                  25                  30          


His Arg Pro Gly Gln Ala Pro Ile Leu Leu Ile Tyr Asn Asn Gln Asp 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr Pro Asp Ile Asn 
    50                  55                  60                  


Phe Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys His Met Trp Asp Ser Arg Ser Gly Phe Ser 
                85                  90                  95      


Trp Ser Phe Gly Gly Ala Thr Arg Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  37
<211>  236
<212>  PRT
<213>  homo sapiens

<400>  37

Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Ala Ser Ile Ser Asp Ser 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Arg Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val His Lys Ser Gly Asp Thr Asn Tyr Ser Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Asn Leu Ser Leu Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Val Ala Ala Thr Ala Ala Asp Ser Gly Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Leu His Gly Arg Arg Ile Tyr Gly Ile Val Ala Phe Asn Glu 
            100                 105                 110         


Trp Phe Thr Tyr Phe Tyr Met Asp Val Trp Gly Asn Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235     


<210>  38
<211>  211
<212>  PRT
<213>  homo sapiens

<400>  38

Ser Asp Ile Ser Val Ala Pro Gly Glu Thr Ala Arg Ile Ser Cys Gly 
1               5                   10                  15      


Glu Lys Ser Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln His Arg Ala 
            20                  25                  30          


Gly Gln Ala Pro Ser Leu Ile Ile Tyr Asn Asn Gln Asp Arg Pro Ser 
        35                  40                  45              


Gly Ile Pro Glu Arg Phe Ser Gly Ser Pro Asp Ser Pro Phe Gly Thr 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Ser Val Glu Ala Gly Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys His Ile Trp Asp Ser Arg Val Pro Thr Lys Trp Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Thr Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  39
<211>  236
<212>  PRT
<213>  homo sapiens

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Leu Asn Ser Ile Asn Phe 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Leu Arg Met Glu Asp Ser Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235     


<210>  40
<211>  215
<212>  PRT
<213>  homo sapiens

<400>  40

Ser Tyr Glu Leu Thr Gln Glu Thr Gly Val Ser Val Ala Leu Gly Arg 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Ile Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Ser Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Glu Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  41
<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  TPR repeat


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Ala Xaa Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp 
1               5                   10                  15      


Tyr Asp Glu Ala Ile Xaa Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro 
            20                  25                  30          


Xaa Xaa 
        


<210>  42
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  Flexible Linker, Sortase A, BirA, His

<400>  42

Gly Gly Gly Gly Ala Ser Leu Pro Glu Thr Gly Gly Leu Asn Asp Ile 
1               5                   10                  15      


Phe Glu Ala Gln Lys Ile Glu Trp His Glu His His His His His His 
            20                  25                  30          


<210>  43
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  GlySer Linker Sortase A, His

<400>  43

Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Leu Pro Glu Thr Gly Gly His His His His His His 
            20                  25                  


