                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
 
<120>  METHODS OF TREATING SYSTEMIC LUPUS ERYTHEMATOSUS USING A DOMAIN 
       ANTIBODY DIRECTED AGAINST CD28

<130>  12394-WO-PCT

<150>  62/057981
<151>  2014-09-30

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  1

Arg Ala Ser Arg Pro Ile Trp Pro Phe Leu Glu 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  2

Phe Thr Ser Arg Leu Arg His 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  3

Leu Gln Asn Val Ala Asn Pro Ala Thr 
1               5                   


<210>  4
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  5
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  5

Asp Ile Cys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Cys Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Cys Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Cys Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Cys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  10
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Cys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  11
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Cys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  12
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Cys Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Cys Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  14
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Cys Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  15
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Trp Pro Phe 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Arg His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Val Ala Asn Pro Ala 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Cys Val Glu Ile Lys Arg 
            100                 105             


