                         SEQUENCE LISTING

<110>  McLean, Kirk
       Feldman, Rick
       Hermiston, Terry
       Brooks, Alan
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT WITH HEMOPEXIN

<130>  17207.0009USP1

<140>  New Filing
<141>  2014-09-29

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


<210>  2
<211>  1410
<212>  DNA
<213>  Homo sapiens

<400>  2
atggctaggg tactgggagc acccgttgca ctggggttgt ggagcctatg ctggtctctg       60

gccattgcca cccctcttcc tccgactagt gcccatggga atgttgctga aggcgagacc      120

aagccagacc cagacgtgac tgaacgctgc tcagatggct ggagctttga tgctaccacc      180

ctggatgaca atggaaccat gctgtttttt aaaggggagt ttgtgtggaa gagtcacaaa      240

tgggaccggg agttaatctc agagagatgg aagaatttcc ccagccctgt ggatgctgca      300

ttccgtcaag gtcacaacag tgtctttctg atcaaggggg acaaagtctg ggtataccct      360

cctgaaaaga aggagaaagg atacccaaag ttgctccaag atgaatttcc tggaatccca      420

tccccactgg atgcagctgt ggaatgtcac cgtggagaat gtcaagctga aggcgtcctc      480

ttcttccaag gtgaccgcga gtggttctgg gacttggcta cgggaaccat gaaggagcgt      540

tcctggccag ctgttgggaa ctgctcctct gccctgagat ggctgggccg ctactactgc      600

ttccagggta accaattcct gcgcttcgac cctgtcaggg gagaggtgcc tcccaggtac      660

ccgcgggatg tccgagacta cttcatgccc tgccctggca gaggccatgg acacaggaat      720

gggactggcc atgggaacag tacccaccat ggccctgagt atatgcgctg tagcccacat      780

ctagtcttgt ctgcactgac gtctgacaac catggtgcca cctatgcctt cagtgggacc      840

cactactggc gtctggacac cagccgggat ggctggcata gctggcccat tgctcatcag      900

tggccccagg gtccttcagc agtggatgct gccttttcct gggaagaaaa actctatctg      960

gtccagggca cccaggtata tgtcttcctg acaaagggag gctataccct agtaagcggt     1020

tatccgaagc ggctggagaa ggaagtcggg acccctcatg ggattatcct ggactctgtg     1080

gatgcggcct ttatctgccc tgggtcttct cggctccata tcatggcagg acggcggctg     1140

tggtggctgg acctgaagtc aggagcccaa gccacgtgga cagagcttcc ttggccccat     1200

gagaaggtag acggagcctt gtgtatggaa aagtcccttg gccctaactc atgttccgcc     1260

aatggtcccg gcttgtacct catccatggt cccaatttgt actgctacag tgatgtggag     1320

aaactgaatg cagccaaggc ccttccgcaa ccccagaatg tgaccagtct cctgggctgc     1380

actcaccacc atcaccacca tcatcaccat                                      1410


<210>  3
<211>  1451
<212>  DNA
<213>  Homo sapiens

<400>  3
accggtgaat tcgccgccac catggctcgc gttcttggtg cccctgttgc cctcggtctt       60

tggtccctct gttggtcact tgctattgcc actccgctgc ctccgaccag cgcgcacgga      120

aatgtggccg aaggcgaaac taagccagac cctgacgtga ccgagagatg cagcgacgga      180

tggagcttcg acgctactac cctggatgat aacggcacta tgctgttctt taagggggag      240

ttcgtgtgga agtcgcataa gtgggaccgg gagctcatct cagaaaggtg gaagaacttt      300

ccgtccccgg tcgacgctgc atttcggcag ggacacaatt ccgtgttcct gatcaagggg      360

gacaaagtgt gggtgtaccc acctgagaaa aaggagaaag gttacccaaa gctgctccaa      420

gatgagttcc cgggcatccc ctcgcccctc gacgcggcag tggaatgcca tagaggcgaa      480

tgccaagcag aaggcgtgct gtttttccaa ggggacagag aatggttctg ggacctggct      540

acgggaacca tgaaggaacg ctcctggcca gccgtgggaa attgctccag cgcactgcga      600

tggctgggaa gatactactg tttccaagga aatcagtttc ttcgcttcga tcctgtccgc      660

ggagaggtgc ccccacggta cccgcgggac gtgcgcgact attttatgcc gtgtccggga      720

cggggccatg gccaccggaa cggaaccggg catggaaact cgactcatca cggacctgag      780

tacatgaggt gcagcccgca tctcgtgctg tccgccctca cctccgacaa ccatggggct      840

acctatgcat tctcgggtac tcactactgg aggctggata cctcacggga tggatggcac      900

tcgtggccga tcgcgcacca gtggccacag ggcccctcag cagtcgatgc cgctttctca      960

tgggaggaaa agctctacct ggtgcagggt acccaagtct acgtgttcct cactaaggga     1020

ggctacacgc tcgtgtcggg ctacccaaag agactggaga aggaggtggg gactccccat     1080

ggaatcatcc tggactcggt cgatgctgca ttcatctgcc cgggaagctc gcggctgcac     1140

attatggcgg gacgccgcct ttggtggttg gacttgaaat ccggcgccca ggcgacttgg     1200

actgaacttc cgtggcctca cgagaaggtc gacggagcgt tgtgcatgga aaaatctctg     1260

ggaccaaact cctgcagcgc caacggaccg ggattgtacc tgatccacgg accgaatctg     1320

tactgctact cggatgtcga aaaattgaac gcggccaagg cgctccctca gccgcagaac     1380

gtgacctcgc tgcttggatg tacacaccac caccatcacc atcatcacca ccattaggcg     1440

gccgcgctag c                                                          1451


<210>  4
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


