                         SEQUENCE LISTING

<110>  DSM IP Assets B.V.
 
<120>  METHODS FOR GENOMIC MODIFICATION

<130>  30277-WO-PCT

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  1
agttgaccag tgccgttcc                                                    19


<210>  2
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  2
cacgaagtgc acgcagttg                                                    19


<210>  3
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  3
cttctgctga gcagctctgc c                                                 21


<210>  4
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  4
gttcagaccg caaggaaggt tg                                                22


<210>  5
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  5
cgagaacctg gcctactctc c                                                 21


<210>  6
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  6
cagagttgta gtcggtgtca cg                                                22


<210>  7
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  7
gaagggtatc aagaagcgtg cc                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  8
gccgaagttg tgagggtcaa tg                                                22


<210>  9
<211>  1516
<212>  DNA
<213>  Artificial sequence

<220>
<223>  kanMX gene under S.c. tef control, flanked by lox66 and lox71

<400>  9
taccgttcgt ataatgtatg ctatacgaag ttatagatct gtttagcttg cctcgtcccc       60

gccgggtcac ccggccagcg acatggaggc ccagaatacc ctccttgaca gtcttgacgt      120

gcgcagctca ggggcatgat gtgactgtcg cccgtacatt tagcccatac atccccatgt      180

ataatcattt gcatccatac attttgatgg ccgcacggcg cgaagcaaaa attacggctc      240

ctcgctgcgg acctgcgagc agggaaacgc tcccctcaca gacgcgttga attgtcccca      300

cgccgcgccc ctgtagagaa atataaaagg ttaggatttg ccactgaggt tcttctttca      360

tatacttcct tttaaaatct tgctaggata cagttctcac atcacatccg aacataaaca      420

accatgggta aggaaaagac tcacgtttcg aggccgcgat taaattccaa catggatgct      480

gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc gacaatctat      540

cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa aggtagcgtt      600

gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt tatgcctctt      660

ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac cactgcgatc      720

cccggcaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga aaatattgtt      780

gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa ttgtcctttt      840

aacagcgatc gcgtatttcg actcgctcag gcgcaatcac gaatgaataa cggtttggtt      900

gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt ctggaaagaa      960

atgcataagc ttttgccatt ctcaccggat tcagtcgtca ctcatggtga tttctcactt     1020

gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg acgagtcgga     1080

atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga gttttctcct     1140

tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat gaataaattg     1200

cagtttcatt tgatgctcga tgagtttttc taacagtact gacaataaaa agattcttgt     1260

tttcaagaac ttgtcatttg tatagttttt ttatattgta gttgttctat tttaatcaaa     1320

tgttagcgtg atttatattt tttttcgcct cgacatcatc tgcccagatg cgaagttaag     1380

tgcgcagaaa gtaatatcat gcgtcaatcg tatgtgaatg ctggtcgcta tactgctgtc     1440

gattcgatac taacgccgcc atccagtgtc gaaaacgagc tcataacttc gtataatgta     1500

tgctatacga acggta                                                     1516


<210>  10
<211>  1736
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hph gene under S.c. tef control, flanked by lox66 and lox71

<400>  10
taccgttcgt ataatgtatg ctatacgaag ttatagatct gtttagcttg cctcgtcccc       60

gccgggtcac ccggccagcg acatggaggc ccagaatacc ctccttgaca gtcttgacgt      120

gcgcagctca ggggcatgat gtgactgtcg cccgtacatt tagcccatac atccccatgt      180

ataatcattt gcatccatac attttgatgg ccgcacggcg cgaagcaaaa attacggctc      240

ctcgctgcgg acctgcgagc agggaaacgc tcccctcaca gacgcgttga attgtcccca      300

cgccgcgccc ctgtagagaa atataaaagg ttaggatttg ccactgaggt tcttctttca      360

tatacttcct tttaaaatct tgctaggata cagttctcac atcacatccg aacataaaca      420

accatgggta aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag      480

ttcgacagcg tgtccgacct gatgcagctc tcggagggcg aagaatctcg tgctttcagc      540

ttcgatgtag gagggcgtgg atatgtcctg cgggtaaata gctgcgccga tggtttctac      600

aaagatcgtt atgtttatcg gcactttgca tcggccgcgc tcccgattcc ggaagtgctt      660

gacattgggg aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc      720

acgttgcaag acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggcc      780

atggatgcga tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg      840

caaggaatcg gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat      900

gtgtatcact ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc      960

gatgagctga tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat     1020

ttcggctcca acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc     1080

gaggcgatgt tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg     1140

ttggcttgta tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga     1200

tcgccgcggc tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg     1260

gttgacggca atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga     1320

tccggagccg ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc     1380

gatggctgtg tagaagtact cgccgatagt ggaaaccgac gccccagcac tcgtccgagg     1440

gcaaaggaat aatcagtact gacaataaaa agattcttgt tttcaagaac ttgtcatttg     1500

tatagttttt ttatattgta gttgttctat tttaatcaaa tgttagcgtg atttatattt     1560

tttttcgcct cgacatcatc tgcccagatg cgaagttaag tgcgcagaaa gtaatatcat     1620

gcgtcaatcg tatgtgaatg ctggtcgcta tactgctgtc gattcgatac taacgccgcc     1680

atccagtgtc gaaaacgagc tcataacttc gtataatgta tgctatacga acggta         1736


<210>  11
<211>  1280
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nat1 gene under S.c. tef control, flanked by lox66 and lox71

<400>  11
taccgttcgt ataatgtatg ctatacgaag ttatagatct gtttagcttg cctcgtcccc       60

gccgggtcac ccggccagcg acatggaggc ccagaatacc ctccttgaca gtcttgacgt      120

gcgcagctca ggggcatgat gtgactgtcg cccgtacatt tagcccatac atccccatgt      180

ataatcattt gcatccatac attttgatgg ccgcacggcg cgaagcaaaa attacggctc      240

ctcgctgcgg acctgcgagc agggaaacgc tcccctcaca gacgcgttga attgtcccca      300

cgccgcgccc ctgtagagaa atataaaagg ttaggatttg ccactgaggt tcttctttca      360

tatacttcct tttaaaatct tgctaggata cagttctcac atcacatccg aacataaaca      420

accatgggta ccactcttga cgacacggct taccggtacc gcaccagtgt cccgggggac      480

gccgaggcca tcgaggcact ggatgggtcc ttcaccaccg acaccgtctt ccgcgtcacc      540

gccaccgggg acggcttcac cctgcgggag gtgccggtgg acccgcccct gaccaaggtg      600

ttccccgacg acgaatcgga cgacgaatcg gacgacgggg aggacggcga cccggactcc      660

cggacgttcg tcgcgtacgg ggacgacggc gacctggcgg gcttcgtggt cgtgtcgtac      720

tccggctgga accgccggct gaccgtcgag gacatcgagg tcgccccgga gcaccggggg      780

cacggggtcg ggcgcgcgtt gatggggctc gcgacggagt tcgcccgcga gcggggcgcc      840

gggcacctct ggctggaggt caccaacgtc aacgcaccgg cgatccacgc gtaccggcgg      900

atggggttca ccctctgcgg cctggacacc gccctgtacg acggcaccgc ctcggacggc      960

gagcaggcgc tctacatgag catgccctgc ccctaatcag tactgacaat aaaaagattc     1020

ttgttttcaa gaacttgtca tttgtatagt ttttttatat tgtagttgtt ctattttaat     1080

caaatgttag cgtgatttat attttttttc gcctcgacat catctgccca gatgcgaagt     1140

taagtgcgca gaaagtaata tcatgcgtca atcgtatgtg aatgctggtc gctatactgc     1200

tgtcgattcg atactaacgc cgccatccag tgtcgaaaac gagctcataa cttcgtataa     1260

tgtatgctat acgaacggta                                                 1280


