                         SEQUENCE LISTING

<110>  EVOLVA SA
 
<120>  PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTS

<130>  14-830-WO

<150>  US 62/048,178
<151>  2014-09-09

<150>  US 62/103,547
<151>  2015-01-14

<150>  US 61/117,396
<151>  2015-02-17

<150>  US 62/148,585
<151>  2015-04-16

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  784
<212>  PRT
<213>  Stevia rebaudiana

<400>  1

Met Asn Leu Ser Leu Cys Ile Ala Ser Pro Leu Leu Thr Lys Ser Asn 
1               5                   10                  15      


Arg Pro Ala Ala Leu Ser Ala Ile His Thr Ala Ser Thr Ser His Gly 
            20                  25                  30          


Gly Gln Thr Asn Pro Thr Asn Leu Ile Ile Asp Thr Thr Lys Glu Arg 
        35                  40                  45              


Ile Gln Lys Gln Phe Lys Asn Val Glu Ile Ser Val Ser Ser Tyr Asp 
    50                  55                  60                  


Thr Ala Trp Val Ala Met Val Pro Ser Pro Asn Ser Pro Lys Ser Pro 
65                  70                  75                  80  


Cys Phe Pro Glu Cys Leu Asn Trp Leu Ile Asn Asn Gln Leu Asn Asp 
                85                  90                  95      


Gly Ser Trp Gly Leu Val Asn His Thr His Asn His Asn His Pro Leu 
            100                 105                 110         


Leu Lys Asp Ser Leu Ser Ser Thr Leu Ala Cys Ile Val Ala Leu Lys 
        115                 120                 125             


Arg Trp Asn Val Gly Glu Asp Gln Ile Asn Lys Gly Leu Ser Phe Ile 
    130                 135                 140                 


Glu Ser Asn Leu Ala Ser Ala Thr Glu Lys Ser Gln Pro Ser Pro Ile 
145                 150                 155                 160 


Gly Phe Asp Ile Ile Phe Pro Gly Leu Leu Glu Tyr Ala Lys Asn Leu 
                165                 170                 175     


Asp Ile Asn Leu Leu Ser Lys Gln Thr Asp Phe Ser Leu Met Leu His 
            180                 185                 190         


Lys Arg Glu Leu Glu Gln Lys Arg Cys His Ser Asn Glu Met Asp Gly 
        195                 200                 205             


Tyr Leu Ala Tyr Ile Ser Glu Gly Leu Gly Asn Leu Tyr Asp Trp Asn 
    210                 215                 220                 


Met Val Lys Lys Tyr Gln Met Lys Asn Gly Ser Val Phe Asn Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Ala Ala Ala Phe Ile Asn His Gln Asn Pro Gly Cys Leu 
                245                 250                 255     


Asn Tyr Leu Asn Ser Leu Leu Asp Lys Phe Gly Asn Ala Val Pro Thr 
            260                 265                 270         


Val Tyr Pro His Asp Leu Phe Ile Arg Leu Ser Met Val Asp Thr Ile 
        275                 280                 285             


Glu Arg Leu Gly Ile Ser His His Phe Arg Val Glu Ile Lys Asn Val 
    290                 295                 300                 


Leu Asp Glu Thr Tyr Arg Cys Trp Val Glu Arg Asp Glu Gln Ile Phe 
305                 310                 315                 320 


Met Asp Val Val Thr Cys Ala Leu Ala Phe Arg Leu Leu Arg Ile Asn 
                325                 330                 335     


Gly Tyr Glu Val Ser Pro Asp Pro Leu Ala Glu Ile Thr Asn Glu Leu 
            340                 345                 350         


Ala Leu Lys Asp Glu Tyr Ala Ala Leu Glu Thr Tyr His Ala Ser His 
        355                 360                 365             


Ile Leu Tyr Gln Glu Asp Leu Ser Ser Gly Lys Gln Ile Leu Lys Ser 
    370                 375                 380                 


Ala Asp Phe Leu Lys Glu Ile Ile Ser Thr Asp Ser Asn Arg Leu Ser 
385                 390                 395                 400 


Lys Leu Ile His Lys Glu Val Glu Asn Ala Leu Lys Phe Pro Ile Asn 
                405                 410                 415     


Thr Gly Leu Glu Arg Ile Asn Thr Arg Arg Asn Ile Gln Leu Tyr Asn 
            420                 425                 430         


Val Asp Asn Thr Arg Ile Leu Lys Thr Thr Tyr His Ser Ser Asn Ile 
        435                 440                 445             


Ser Asn Thr Asp Tyr Leu Arg Leu Ala Val Glu Asp Phe Tyr Thr Cys 
    450                 455                 460                 


Gln Ser Ile Tyr Arg Glu Glu Leu Lys Gly Leu Glu Arg Trp Val Val 
465                 470                 475                 480 


Glu Asn Lys Leu Asp Gln Leu Lys Phe Ala Arg Gln Lys Thr Ala Tyr 
                485                 490                 495     


Cys Tyr Phe Ser Val Ala Ala Thr Leu Ser Ser Pro Glu Leu Ser Asp 
            500                 505                 510         


Ala Arg Ile Ser Trp Ala Lys Asn Gly Ile Leu Thr Thr Val Val Asp 
        515                 520                 525             


Asp Phe Phe Asp Ile Gly Gly Thr Ile Asp Glu Leu Thr Asn Leu Ile 
    530                 535                 540                 


Gln Cys Val Glu Lys Trp Asn Val Asp Val Asp Lys Asp Cys Cys Ser 
545                 550                 555                 560 


Glu His Val Arg Ile Leu Phe Leu Ala Leu Lys Asp Ala Ile Cys Trp 
                565                 570                 575     


Ile Gly Asp Glu Ala Phe Lys Trp Gln Ala Arg Asp Val Thr Ser His 
            580                 585                 590         


Val Ile Gln Thr Trp Leu Glu Leu Met Asn Ser Met Leu Arg Glu Ala 
        595                 600                 605             


Ile Trp Thr Arg Asp Ala Tyr Val Pro Thr Leu Asn Glu Tyr Met Glu 
    610                 615                 620                 


Asn Ala Tyr Val Ser Phe Ala Leu Gly Pro Ile Val Lys Pro Ala Ile 
625                 630                 635                 640 


Tyr Phe Val Gly Pro Lys Leu Ser Glu Glu Ile Val Glu Ser Ser Glu 
                645                 650                 655     


Tyr His Asn Leu Phe Lys Leu Met Ser Thr Gln Gly Arg Leu Leu Asn 
            660                 665                 670         


Asp Ile His Ser Phe Lys Arg Glu Phe Lys Glu Gly Lys Leu Asn Ala 
        675                 680                 685             


Val Ala Leu His Leu Ser Asn Gly Glu Ser Gly Lys Val Glu Glu Glu 
    690                 695                 700                 


Val Val Glu Glu Met Met Met Met Ile Lys Asn Lys Arg Lys Glu Leu 
705                 710                 715                 720 


Met Lys Leu Ile Phe Glu Glu Asn Gly Ser Ile Val Pro Arg Ala Cys 
                725                 730                 735     


Lys Asp Ala Phe Trp Asn Met Cys His Val Leu Asn Phe Phe Tyr Ala 
            740                 745                 750         


Asn Asp Asp Gly Phe Thr Gly Asn Thr Ile Leu Asp Thr Val Lys Asp 
        755                 760                 765             


Ile Ile Tyr Asn Pro Leu Val Leu Val Asn Glu Asn Glu Glu Gln Arg 
    770                 775                 780                 


<210>  2
<211>  784
<212>  PRT
<213>  Stevia rebaudiana

<400>  2

Met Asn Leu Ser Leu Cys Ile Ala Ser Pro Leu Leu Thr Lys Ser Ser 
1               5                   10                  15      


Arg Pro Thr Ala Leu Ser Ala Ile His Thr Ala Ser Thr Ser His Gly 
            20                  25                  30          


Gly Gln Thr Asn Pro Thr Asn Leu Ile Ile Asp Thr Thr Lys Glu Arg 
        35                  40                  45              


Ile Gln Lys Leu Phe Lys Asn Val Glu Ile Ser Val Ser Ser Tyr Asp 
    50                  55                  60                  


Thr Ala Trp Val Ala Met Val Pro Ser Pro Asn Ser Pro Lys Ser Pro 
65                  70                  75                  80  


Cys Phe Pro Glu Cys Leu Asn Trp Leu Ile Asn Asn Gln Leu Asn Asp 
                85                  90                  95      


Gly Ser Trp Gly Leu Val Asn His Thr His Asn His Asn His Pro Leu 
            100                 105                 110         


Leu Lys Asp Ser Leu Ser Ser Thr Leu Ala Cys Ile Val Ala Leu Lys 
        115                 120                 125             


Arg Trp Asn Val Gly Glu Asp Gln Ile Asn Lys Gly Leu Ser Phe Ile 
    130                 135                 140                 


Glu Ser Asn Leu Ala Ser Ala Thr Asp Lys Ser Gln Pro Ser Pro Ile 
145                 150                 155                 160 


Gly Phe Asp Ile Ile Phe Pro Gly Leu Leu Glu Tyr Ala Lys Asn Leu 
                165                 170                 175     


Asp Ile Asn Leu Leu Ser Lys Gln Thr Asp Phe Ser Leu Met Leu His 
            180                 185                 190         


Lys Arg Glu Leu Glu Gln Lys Arg Cys His Ser Asn Glu Ile Asp Gly 
        195                 200                 205             


Tyr Leu Ala Tyr Ile Ser Glu Gly Leu Gly Asn Leu Tyr Asp Trp Asn 
    210                 215                 220                 


Met Val Lys Lys Tyr Gln Met Lys Asn Gly Ser Val Phe Asn Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Ala Ala Ala Phe Ile Asn His Gln Asn Pro Gly Cys Leu 
                245                 250                 255     


Asn Tyr Leu Asn Ser Leu Leu Asp Lys Phe Gly Asn Ala Val Pro Thr 
            260                 265                 270         


Val Tyr Pro Leu Asp Leu Tyr Ile Arg Leu Ser Met Val Asp Thr Ile 
        275                 280                 285             


Glu Arg Leu Gly Ile Ser His His Phe Arg Val Glu Ile Lys Asn Val 
    290                 295                 300                 


Leu Asp Glu Thr Tyr Arg Cys Trp Val Glu Arg Asp Glu Gln Ile Phe 
305                 310                 315                 320 


Met Asp Val Val Thr Cys Ala Leu Ala Phe Arg Leu Leu Arg Ile His 
                325                 330                 335     


Gly Tyr Lys Val Ser Pro Asp Gln Leu Ala Glu Ile Thr Asn Glu Leu 
            340                 345                 350         


Ala Phe Lys Asp Glu Tyr Ala Ala Leu Glu Thr Tyr His Ala Ser Gln 
        355                 360                 365             


Ile Leu Tyr Gln Glu Asp Leu Ser Ser Gly Lys Gln Ile Leu Lys Ser 
    370                 375                 380                 


Ala Asp Phe Leu Lys Gly Ile Leu Ser Thr Asp Ser Asn Arg Leu Ser 
385                 390                 395                 400 


Lys Leu Ile His Lys Glu Val Glu Asn Ala Leu Lys Phe Pro Ile Asn 
                405                 410                 415     


Thr Gly Leu Glu Arg Ile Asn Thr Arg Arg Asn Ile Gln Leu Tyr Asn 
            420                 425                 430         


Val Asp Asn Thr Arg Ile Leu Lys Thr Thr Tyr His Ser Ser Asn Ile 
        435                 440                 445             


Ser Asn Thr Tyr Tyr Leu Arg Leu Ala Val Glu Asp Phe Tyr Thr Cys 
    450                 455                 460                 


Gln Ser Ile Tyr Arg Glu Glu Leu Lys Gly Leu Glu Arg Trp Val Val 
465                 470                 475                 480 


Gln Asn Lys Leu Asp Gln Leu Lys Phe Ala Arg Gln Lys Thr Ala Tyr 
                485                 490                 495     


Cys Tyr Phe Ser Val Ala Ala Thr Leu Ser Ser Pro Glu Leu Ser Asp 
            500                 505                 510         


Ala Arg Ile Ser Trp Ala Lys Asn Gly Ile Leu Thr Thr Val Val Asp 
        515                 520                 525             


Asp Phe Phe Asp Ile Gly Gly Thr Ile Asp Glu Leu Thr Asn Leu Ile 
    530                 535                 540                 


Gln Cys Val Glu Lys Trp Asn Val Asp Val Asp Lys Asp Cys Cys Ser 
545                 550                 555                 560 


Glu His Val Arg Ile Leu Phe Leu Ala Leu Lys Asp Ala Ile Cys Trp 
                565                 570                 575     


Ile Gly Asp Glu Ala Phe Lys Trp Gln Ala Arg Asp Val Thr Ser His 
            580                 585                 590         


Val Ile Gln Thr Trp Leu Glu Leu Met Asn Ser Met Leu Arg Glu Ala 
        595                 600                 605             


Ile Trp Thr Arg Asp Ala Tyr Val Pro Thr Leu Asn Glu Tyr Met Glu 
    610                 615                 620                 


Asn Ala Tyr Val Ser Phe Ala Leu Gly Pro Ile Val Lys Pro Ala Ile 
625                 630                 635                 640 


Tyr Phe Val Gly Pro Lys Leu Ser Glu Glu Ile Val Glu Ser Ser Glu 
                645                 650                 655     


Tyr His Asn Leu Phe Lys Leu Met Ser Thr Gln Gly Arg Leu Leu Asn 
            660                 665                 670         


Asp Ile His Ser Phe Lys Arg Glu Phe Lys Glu Gly Lys Leu Asn Ala 
        675                 680                 685             


Val Ala Leu His Leu Ser Asn Gly Glu Ser Gly Lys Val Glu Glu Glu 
    690                 695                 700                 


Val Val Glu Glu Met Met Met Met Ile Lys Asn Lys Arg Lys Glu Leu 
705                 710                 715                 720 


Met Lys Leu Ile Phe Glu Glu Asn Gly Ser Ile Val Pro Arg Ala Cys 
                725                 730                 735     


Lys Asp Ala Phe Trp Asn Met Cys His Val Leu Asn Phe Phe Tyr Ala 
            740                 745                 750         


Asn Asp Asp Gly Phe Thr Gly Asn Thr Ile Leu Asp Thr Val Lys Asp 
        755                 760                 765             


Ile Ile Tyr Asn Pro Leu Val Leu Val Asn Glu Asn Glu Glu Gln Arg 
    770                 775                 780                 


<210>  3
<211>  590
<212>  PRT
<213>  Zea mays

<400>  3

Met Ala Met Pro Val Lys Leu Thr Pro Ala Ser Leu Ser Leu Lys Ala 
1               5                   10                  15      


Val Cys Cys Arg Phe Ser Ser Gly Gly His Ala Leu Arg Phe Gly Ser 
            20                  25                  30          


Ser Leu Pro Cys Trp Arg Arg Thr Pro Thr Gln Arg Ser Thr Ser Ser 
        35                  40                  45              


Ser Thr Thr Arg Pro Ala Ala Glu Val Ser Ser Gly Lys Ser Lys Gln 
    50                  55                  60                  


His Asp Gln Glu Ala Ser Glu Ala Thr Ile Arg Gln Gln Leu Gln Leu 
65                  70                  75                  80  


Val Asp Val Leu Glu Asn Met Gly Ile Ser Arg His Phe Ala Ala Glu 
                85                  90                  95      


Ile Lys Cys Ile Leu Asp Arg Thr Tyr Arg Ser Trp Leu Gln Arg His 
            100                 105                 110         


Glu Glu Ile Met Leu Asp Thr Met Thr Cys Ala Met Ala Phe Arg Ile 
        115                 120                 125             


Leu Arg Leu Asn Gly Tyr Asn Val Ser Ser Asp Glu Leu Tyr His Val 
    130                 135                 140                 


Val Glu Ala Ser Gly Leu His Asn Ser Leu Gly Gly Tyr Leu Asn Asp 
145                 150                 155                 160 


Thr Arg Thr Leu Leu Glu Leu His Lys Ala Ser Thr Val Ser Ile Ser 
                165                 170                 175     


Glu Asp Glu Ser Ile Leu Asp Ser Ile Gly Ser Arg Ser Arg Thr Leu 
            180                 185                 190         


Leu Arg Glu Gln Leu Glu Ser Gly Gly Ala Leu Arg Lys Pro Ser Leu 
        195                 200                 205             


Phe Lys Glu Val Glu His Ala Leu Asp Gly Pro Phe Tyr Thr Thr Leu 
    210                 215                 220                 


Asp Arg Leu His His Arg Trp Asn Ile Glu Asn Phe Asn Ile Ile Glu 
225                 230                 235                 240 


Gln His Met Leu Glu Thr Pro Tyr Leu Ser Asn Gln His Thr Ser Arg 
                245                 250                 255     


Asp Ile Leu Ala Leu Ser Ile Arg Asp Phe Ser Ser Ser Gln Phe Thr 
            260                 265                 270         


Tyr Gln Gln Glu Leu Gln His Leu Glu Ser Trp Val Lys Glu Cys Arg 
        275                 280                 285             


Leu Asp Gln Leu Gln Phe Ala Arg Gln Lys Leu Ala Tyr Phe Tyr Leu 
    290                 295                 300                 


Ser Ala Ala Gly Thr Met Phe Ser Pro Glu Leu Ser Asp Ala Arg Thr 
305                 310                 315                 320 


Leu Trp Ala Lys Asn Gly Val Leu Thr Thr Ile Val Asp Asp Phe Phe 
                325                 330                 335     


Asp Val Ala Gly Ser Lys Glu Glu Leu Glu Asn Leu Val Met Leu Val 
            340                 345                 350         


Glu Met Trp Asp Glu His His Lys Val Glu Phe Tyr Ser Glu Gln Val 
        355                 360                 365             


Glu Ile Ile Phe Ser Ser Ile Tyr Asp Ser Val Asn Gln Leu Gly Glu 
    370                 375                 380                 


Lys Ala Ser Leu Val Gln Asp Arg Ser Ile Thr Lys His Leu Val Glu 
385                 390                 395                 400 


Ile Trp Leu Asp Leu Leu Lys Ser Met Met Thr Glu Val Glu Trp Arg 
                405                 410                 415     


Leu Ser Lys Tyr Val Pro Thr Glu Lys Glu Tyr Met Ile Asn Ala Ser 
            420                 425                 430         


Leu Ile Phe Gly Leu Gly Pro Ile Val Leu Pro Ala Leu Tyr Phe Val 
        435                 440                 445             


Gly Pro Lys Ile Ser Glu Ser Ile Val Lys Asp Pro Glu Tyr Asp Glu 
    450                 455                 460                 


Leu Phe Lys Leu Met Ser Thr Cys Gly Arg Leu Leu Asn Asp Val Gln 
465                 470                 475                 480 


Thr Phe Glu Arg Glu Tyr Asn Glu Gly Lys Leu Asn Ser Val Ser Leu 
                485                 490                 495     


Leu Val Leu His Gly Gly Pro Met Ser Ile Ser Asp Ala Lys Arg Lys 
            500                 505                 510         


Leu Gln Lys Pro Ile Asp Thr Cys Arg Arg Asp Leu Leu Ser Leu Val 
        515                 520                 525             


Leu Arg Glu Glu Ser Val Val Pro Arg Pro Cys Lys Glu Leu Phe Trp 
    530                 535                 540                 


Lys Met Cys Lys Val Cys Tyr Phe Phe Tyr Ser Thr Thr Asp Gly Phe 
545                 550                 555                 560 


Ser Ser Gln Val Glu Arg Ala Lys Glu Val Asp Ala Val Ile Asn Glu 
                565                 570                 575     


Pro Leu Lys Leu Gln Gly Ser His Thr Leu Val Ser Asp Val 
            580                 585                 590 


<210>  4
<211>  775
<212>  PRT
<213>  Populus trichocarpa

<400>  4

Met Ser Cys Ile Arg Pro Trp Phe Cys Pro Ser Ser Ile Ser Ala Thr 
1               5                   10                  15      


Leu Thr Asp Pro Ala Ser Lys Leu Val Thr Gly Glu Phe Lys Thr Thr 
            20                  25                  30          


Ser Leu Asn Phe His Gly Thr Lys Glu Arg Ile Lys Lys Met Phe Asp 
        35                  40                  45              


Lys Ile Glu Leu Ser Val Ser Ser Tyr Asp Thr Ala Trp Val Ala Met 
    50                  55                  60                  


Val Pro Ser Pro Asp Cys Pro Glu Thr Pro Cys Phe Pro Glu Cys Thr 
65                  70                  75                  80  


Lys Trp Ile Leu Glu Asn Gln Leu Gly Asp Gly Ser Trp Ser Leu Pro 
                85                  90                  95      


His Gly Asn Pro Leu Leu Val Lys Asp Ala Leu Ser Ser Thr Leu Ala 
            100                 105                 110         


Cys Ile Leu Ala Leu Lys Arg Trp Gly Ile Gly Glu Glu Gln Ile Asn 
        115                 120                 125             


Lys Gly Leu Arg Phe Ile Glu Leu Asn Ser Ala Ser Val Thr Asp Asn 
    130                 135                 140                 


Glu Gln His Lys Pro Ile Gly Phe Asp Ile Ile Phe Pro Gly Met Ile 
145                 150                 155                 160 


Glu Tyr Ala Lys Asp Leu Asp Leu Asn Leu Pro Leu Lys Pro Thr Asp 
                165                 170                 175     


Ile Asn Ser Met Leu His Arg Arg Ala Leu Glu Leu Thr Ser Gly Gly 
            180                 185                 190         


Gly Lys Asn Leu Glu Gly Arg Arg Ala Tyr Leu Ala Tyr Val Ser Glu 
        195                 200                 205             


Gly Ile Gly Lys Leu Gln Asp Trp Glu Met Ala Met Lys Tyr Gln Arg 
    210                 215                 220                 


Lys Asn Gly Ser Leu Phe Asn Ser Pro Ser Thr Thr Ala Ala Ala Phe 
225                 230                 235                 240 


Ile His Ile Gln Asp Ala Glu Cys Leu His Tyr Ile Arg Ser Leu Leu 
                245                 250                 255     


Gln Lys Phe Gly Asn Ala Val Pro Thr Ile Tyr Pro Leu Asp Ile Tyr 
            260                 265                 270         


Ala Arg Leu Ser Met Val Asp Ala Leu Glu Arg Leu Gly Ile Asp Arg 
        275                 280                 285             


His Phe Arg Lys Glu Arg Lys Phe Val Leu Asp Glu Thr Tyr Arg Phe 
    290                 295                 300                 


Trp Leu Gln Gly Glu Glu Glu Ile Phe Ser Asp Asn Ala Thr Cys Ala 
305                 310                 315                 320 


Leu Ala Phe Arg Ile Leu Arg Leu Asn Gly Tyr Asp Val Ser Leu Glu 
                325                 330                 335     


Asp His Phe Ser Asn Ser Leu Gly Gly Tyr Leu Lys Asp Ser Gly Ala 
            340                 345                 350         


Ala Leu Glu Leu Tyr Arg Ala Leu Gln Leu Ser Tyr Pro Asp Glu Ser 
        355                 360                 365             


Leu Leu Glu Lys Gln Asn Ser Arg Thr Ser Tyr Phe Leu Lys Gln Gly 
    370                 375                 380                 


Leu Ser Asn Val Ser Leu Cys Gly Asp Arg Leu Arg Lys Asn Ile Ile 
385                 390                 395                 400 


Gly Glu Val His Asp Ala Leu Asn Phe Pro Asp His Ala Asn Leu Gln 
                405                 410                 415     


Arg Leu Ala Ile Arg Arg Arg Ile Lys His Tyr Ala Thr Asp Asp Thr 
            420                 425                 430         


Arg Ile Leu Lys Thr Ser Tyr Arg Cys Ser Thr Ile Gly Asn Gln Asp 
        435                 440                 445             


Phe Leu Lys Leu Ala Val Glu Asp Phe Asn Ile Cys Gln Ser Ile Gln 
    450                 455                 460                 


Arg Glu Glu Phe Lys His Ile Glu Arg Trp Val Val Glu Arg Arg Leu 
465                 470                 475                 480 


Asp Lys Leu Lys Phe Ala Arg Gln Lys Glu Ala Tyr Cys Tyr Phe Ser 
                485                 490                 495     


Ala Ala Ala Thr Leu Phe Ala Pro Glu Leu Ser Asp Ala Arg Met Ser 
            500                 505                 510         


Trp Ala Lys Asn Gly Val Leu Thr Thr Val Val Asp Asp Phe Phe Asp 
        515                 520                 525             


Val Gly Gly Ser Glu Glu Glu Leu Val Asn Leu Ile Glu Leu Ile Glu 
    530                 535                 540                 


Arg Trp Asp Val Asn Gly Ser Ala Asp Phe Cys Ser Glu Glu Val Glu 
545                 550                 555                 560 


Ile Ile Tyr Ser Ala Ile His Ser Thr Ile Ser Glu Ile Gly Asp Lys 
                565                 570                 575     


Ser Phe Gly Trp Gln Gly Arg Asp Val Lys Ser His Val Ile Lys Ile 
            580                 585                 590         


Trp Leu Asp Leu Leu Lys Ser Met Leu Thr Glu Ala Gln Trp Ser Ser 
        595                 600                 605             


Asn Lys Ser Val Pro Thr Leu Asp Glu Tyr Met Thr Thr Ala His Val 
    610                 615                 620                 


Ser Phe Ala Leu Gly Pro Ile Val Leu Pro Ala Leu Tyr Phe Val Gly 
625                 630                 635                 640 


Pro Lys Leu Ser Glu Glu Val Ala Gly His Pro Glu Leu Leu Asn Leu 
                645                 650                 655     


Tyr Lys Val Met Ser Thr Cys Gly Arg Leu Leu Asn Asp Trp Arg Ser 
            660                 665                 670         


Phe Lys Arg Glu Ser Glu Glu Gly Lys Leu Asn Ala Ile Ser Leu Tyr 
        675                 680                 685             


Met Ile His Ser Gly Gly Ala Ser Thr Glu Glu Glu Thr Ile Glu His 
    690                 695                 700                 


Phe Lys Gly Leu Ile Asp Ser Gln Arg Arg Gln Leu Leu Gln Leu Val 
705                 710                 715                 720 


Leu Gln Glu Lys Asp Ser Ile Ile Pro Arg Pro Cys Lys Asp Leu Phe 
                725                 730                 735     


Trp Asn Met Ile Lys Leu Leu His Thr Phe Tyr Met Lys Asp Asp Gly 
            740                 745                 750         


Phe Thr Ser Asn Glu Met Arg Asn Val Val Lys Ala Ile Ile Asn Glu 
        755                 760                 765             


Pro Ile Ser Leu Asp Glu Leu 
    770                 775 


<210>  5
<211>  2506
<212>  DNA
<213>  Arabidopsis thaliana

<400>  5
cgtcagtcat caaggctaat tcgtcgcgag ttgctacgac gccgtttcgg ttgcttctgg       60

tttctttatg tctatcaacc ttcgctcctc cggttgttcg tctccgatct cagctacttt      120

ggaacgagga ttggactcag aagtacagac aagagctaac aatgtgagct ttgagcaaac      180

aaaggagaag attaggaaga tgttggagaa agtggagctt tctgtttcgg cctacgatac      240

tagttgggta gcaatggttc catcaccgag ctcccaaaat gctccacttt tcccacagtg      300

tgtgaaatgg ttattggata atcaacatga agatggatct tggggacttg ataaccatga      360

ccatcaatct cttaagaagg atgtgttatc atctacactg gctagtatcc tcgcgttaaa      420

gaagtgggga attggtgaaa gacaaataaa caagggtctc cagtttattg agctgaattc      480

tgcattagtc actgatgaaa ccatacagaa accaacaggg tttgatatta tatttcctgg      540

gatgattaaa tatgctagag atttgaatct gacgattcca ttgggctcag aagtggtgga      600

tgacatgata cgaaaaagag atctggatct taaatgtgat agtgaaaagt tttcaaaggg      660

aagagaagca tatctggcct atgttttaga ggggacaaga aacctaaaag attgggattt      720

gatagtcaaa tatcaaagga aaaatgggtc actgtttgat tctccagcca caacagcagc      780

tgcttttact cagtttggga atgatggttg tctccgttat ctctgttctc tccttcagaa      840

attcgaggct gcagttcctt cagtttatcc atttgatcaa tatgcacgcc ttagtataat      900

tgtcactctt gaaagcttag gaattgatag agatttcaaa accgaaatca aaagcatatt      960

ggatgaaacc tatagatatt ggcttcgtgg ggatgaagaa atatgtttgg acttggccac     1020

ttgtgctttg gctttccgat tattgcttgc tcatggctat gatgtgtctt acgatccgct     1080

aaaaccattt gcagaagaat ctggtttctc tgatactttg gaaggatatg ttaagaatac     1140

gttttctgtg ttagaattat ttaaggctgc tcaaagttat ccacatgaat cagctttgaa     1200

gaagcagtgt tgttggacta aacaatatct ggagatggaa ttgtccagct gggttaagac     1260

ctctgttcga gataaatacc tcaagaaaga ggtcgaggat gctcttgctt ttccctccta     1320

tgcaagccta gaaagatcag atcacaggag aaaaatactc aatggttctg ctgtggaaaa     1380

caccagagtt acaaaaacct catatcgttt gcacaatatt tgcacctctg atatcctgaa     1440

gttagctgtg gatgacttca atttctgcca gtccatacac cgtgaagaaa tggaacgtct     1500

tgataggtgg attgtggaga atagattgca ggaactgaaa tttgccagac agaagctggc     1560

ttactgttat ttctctgggg ctgcaacttt attttctcca gaactatctg atgctcgtat     1620

atcgtgggcc aaaggtggag tacttacaac ggttgtagac gacttctttg atgttggagg     1680

gtccaaagaa gaactggaaa acctcataca cttggtcgaa aagtgggatt tgaacggtgt     1740

tcctgagtac agctcagaac atgttgagat catattctca gttctaaggg acaccattct     1800

cgaaacagga gacaaagcat tcacctatca aggacgcaat gtgacacacc acattgtgaa     1860

aatttggttg gatctgctca agtctatgtt gagagaagcc gagtggtcca gtgacaagtc     1920

aacaccaagc ttggaggatt acatggaaaa tgcgtacata tcatttgcat taggaccaat     1980

tgtcctccca gctacctatc tgatcggacc tccacttcca gagaagacag tcgatagcca     2040

ccaatataat cagctctaca agctcgtgag cactatgggt cgtcttctaa atgacataca     2100

aggttttaag agagaaagcg cggaagggaa gctgaatgcg gtttcattgc acatgaaaca     2160

cgagagagac aatcgcagca aagaagtgat catagaatcg atgaaaggtt tagcagagag     2220

aaagagggaa gaattgcata agctagtttt ggaggagaaa ggaagtgtgg ttccaaggga     2280

atgcaaagaa gcgttcttga aaatgagcaa agtgttgaac ttattttaca ggaaggacga     2340

tggattcaca tcaaatgatc tgatgagtct tgttaaatca gtgatctacg agcctgttag     2400

cttacagaaa gaatctttaa cttgatccaa gttgatctgg caggtaaact cagtaaatga     2460

aaataagact ttggtcttct tctttgttgc ttcagaacaa gaagag                    2506


<210>  6
<211>  785
<212>  PRT
<213>  Arabidopsis thaliana

<400>  6

Met Ser Ile Asn Leu Arg Ser Ser Gly Cys Ser Ser Pro Ile Ser Ala 
1               5                   10                  15      


Thr Leu Glu Arg Gly Leu Asp Ser Glu Val Gln Thr Arg Ala Asn Asn 
            20                  25                  30          


Val Ser Phe Glu Gln Thr Lys Glu Lys Ile Arg Lys Met Leu Glu Lys 
        35                  40                  45              


Val Glu Leu Ser Val Ser Ala Tyr Asp Thr Ser Trp Val Ala Met Val 
    50                  55                  60                  


Pro Ser Pro Ser Ser Gln Asn Ala Pro Leu Phe Pro Gln Cys Val Lys 
65                  70                  75                  80  


Trp Leu Leu Asp Asn Gln His Glu Asp Gly Ser Trp Gly Leu Asp Asn 
                85                  90                  95      


His Asp His Gln Ser Leu Lys Lys Asp Val Leu Ser Ser Thr Leu Ala 
            100                 105                 110         


Ser Ile Leu Ala Leu Lys Lys Trp Gly Ile Gly Glu Arg Gln Ile Asn 
        115                 120                 125             


Lys Gly Leu Gln Phe Ile Glu Leu Asn Ser Ala Leu Val Thr Asp Glu 
    130                 135                 140                 


Thr Ile Gln Lys Pro Thr Gly Phe Asp Ile Ile Phe Pro Gly Met Ile 
145                 150                 155                 160 


Lys Tyr Ala Arg Asp Leu Asn Leu Thr Ile Pro Leu Gly Ser Glu Val 
                165                 170                 175     


Val Asp Asp Met Ile Arg Lys Arg Asp Leu Asp Leu Lys Cys Asp Ser 
            180                 185                 190         


Glu Lys Phe Ser Lys Gly Arg Glu Ala Tyr Leu Ala Tyr Val Leu Glu 
        195                 200                 205             


Gly Thr Arg Asn Leu Lys Asp Trp Asp Leu Ile Val Lys Tyr Gln Arg 
    210                 215                 220                 


Lys Asn Gly Ser Leu Phe Asp Ser Pro Ala Thr Thr Ala Ala Ala Phe 
225                 230                 235                 240 


Thr Gln Phe Gly Asn Asp Gly Cys Leu Arg Tyr Leu Cys Ser Leu Leu 
                245                 250                 255     


Gln Lys Phe Glu Ala Ala Val Pro Ser Val Tyr Pro Phe Asp Gln Tyr 
            260                 265                 270         


Ala Arg Leu Ser Ile Ile Val Thr Leu Glu Ser Leu Gly Ile Asp Arg 
        275                 280                 285             


Asp Phe Lys Thr Glu Ile Lys Ser Ile Leu Asp Glu Thr Tyr Arg Tyr 
    290                 295                 300                 


Trp Leu Arg Gly Asp Glu Glu Ile Cys Leu Asp Leu Ala Thr Cys Ala 
305                 310                 315                 320 


Leu Ala Phe Arg Leu Leu Leu Ala His Gly Tyr Asp Val Ser Tyr Asp 
                325                 330                 335     


Pro Leu Lys Pro Phe Ala Glu Glu Ser Gly Phe Ser Asp Thr Leu Glu 
            340                 345                 350         


Gly Tyr Val Lys Asn Thr Phe Ser Val Leu Glu Leu Phe Lys Ala Ala 
        355                 360                 365             


Gln Ser Tyr Pro His Glu Ser Ala Leu Lys Lys Gln Cys Cys Trp Thr 
    370                 375                 380                 


Lys Gln Tyr Leu Glu Met Glu Leu Ser Ser Trp Val Lys Thr Ser Val 
385                 390                 395                 400 


Arg Asp Lys Tyr Leu Lys Lys Glu Val Glu Asp Ala Leu Ala Phe Pro 
                405                 410                 415     


Ser Tyr Ala Ser Leu Glu Arg Ser Asp His Arg Arg Lys Ile Leu Asn 
            420                 425                 430         


Gly Ser Ala Val Glu Asn Thr Arg Val Thr Lys Thr Ser Tyr Arg Leu 
        435                 440                 445             


His Asn Ile Cys Thr Ser Asp Ile Leu Lys Leu Ala Val Asp Asp Phe 
    450                 455                 460                 


Asn Phe Cys Gln Ser Ile His Arg Glu Glu Met Glu Arg Leu Asp Arg 
465                 470                 475                 480 


Trp Ile Val Glu Asn Arg Leu Gln Glu Leu Lys Phe Ala Arg Gln Lys 
                485                 490                 495     


Leu Ala Tyr Cys Tyr Phe Ser Gly Ala Ala Thr Leu Phe Ser Pro Glu 
            500                 505                 510         


Leu Ser Asp Ala Arg Ile Ser Trp Ala Lys Gly Gly Val Leu Thr Thr 
        515                 520                 525             


Val Val Asp Asp Phe Phe Asp Val Gly Gly Ser Lys Glu Glu Leu Glu 
    530                 535                 540                 


Asn Leu Ile His Leu Val Glu Lys Trp Asp Leu Asn Gly Val Pro Glu 
545                 550                 555                 560 


Tyr Ser Ser Glu His Val Glu Ile Ile Phe Ser Val Leu Arg Asp Thr 
                565                 570                 575     


Ile Leu Glu Thr Gly Asp Lys Ala Phe Thr Tyr Gln Gly Arg Asn Val 
            580                 585                 590         


Thr His His Ile Val Lys Ile Trp Leu Asp Leu Leu Lys Ser Met Leu 
        595                 600                 605             


Arg Glu Ala Glu Trp Ser Ser Asp Lys Ser Thr Pro Ser Leu Glu Asp 
    610                 615                 620                 


Tyr Met Glu Asn Ala Tyr Ile Ser Phe Ala Leu Gly Pro Ile Val Leu 
625                 630                 635                 640 


Pro Ala Thr Tyr Leu Ile Gly Pro Pro Leu Pro Glu Lys Thr Val Asp 
                645                 650                 655     


Ser His Gln Tyr Asn Gln Leu Tyr Lys Leu Val Ser Thr Met Gly Arg 
            660                 665                 670         


Leu Leu Asn Asp Ile Gln Gly Phe Lys Arg Glu Ser Ala Glu Gly Lys 
        675                 680                 685             


Leu Asn Ala Val Ser Leu His Met Lys His Glu Arg Asp Asn Arg Ser 
    690                 695                 700                 


Lys Glu Val Ile Ile Glu Ser Met Lys Gly Leu Ala Glu Arg Lys Arg 
705                 710                 715                 720 


Glu Glu Leu His Lys Leu Val Leu Glu Glu Lys Gly Ser Val Val Pro 
                725                 730                 735     


Arg Glu Cys Lys Glu Ala Phe Leu Lys Met Ser Lys Val Leu Asn Leu 
            740                 745                 750         


Phe Tyr Arg Lys Asp Asp Gly Phe Thr Ser Asn Asp Leu Met Ser Leu 
        755                 760                 765             


Val Lys Ser Val Ile Tyr Glu Pro Val Ser Leu Gln Lys Glu Ser Leu 
    770                 775                 780                 


Thr 
785 


<210>  7
<211>  513
<212>  PRT
<213>  Arabidopsis thaliana

<400>  7

Met Asp Ala Val Thr Gly Leu Leu Thr Val Pro Ala Thr Ala Ile Thr 
1               5                   10                  15      


Ile Gly Gly Thr Ala Val Ala Leu Ala Val Ala Leu Ile Phe Trp Tyr 
            20                  25                  30          


Leu Lys Ser Tyr Thr Ser Ala Arg Arg Ser Gln Ser Asn His Leu Pro 
        35                  40                  45              


Arg Val Pro Glu Val Pro Gly Val Pro Leu Leu Gly Asn Leu Leu Gln 
    50                  55                  60                  


Leu Lys Glu Lys Lys Pro Tyr Met Thr Phe Thr Arg Trp Ala Ala Thr 
65                  70                  75                  80  


Tyr Gly Pro Ile Tyr Ser Ile Lys Thr Gly Ala Thr Ser Met Val Val 
                85                  90                  95      


Val Ser Ser Asn Glu Ile Ala Lys Glu Ala Leu Val Thr Arg Phe Gln 
            100                 105                 110         


Ser Ile Ser Thr Arg Asn Leu Ser Lys Ala Leu Lys Val Leu Thr Ala 
        115                 120                 125             


Asp Lys Thr Met Val Ala Met Ser Asp Tyr Asp Asp Tyr His Lys Thr 
    130                 135                 140                 


Val Lys Arg His Ile Leu Thr Ala Val Leu Gly Pro Asn Ala Gln Lys 
145                 150                 155                 160 


Lys His Arg Ile His Arg Asp Ile Met Met Asp Asn Ile Ser Thr Gln 
                165                 170                 175     


Leu His Glu Phe Val Lys Asn Asn Pro Glu Gln Glu Glu Val Asp Leu 
            180                 185                 190         


Arg Lys Ile Phe Gln Ser Glu Leu Phe Gly Leu Ala Met Arg Gln Ala 
        195                 200                 205             


Leu Gly Lys Asp Val Glu Ser Leu Tyr Val Glu Asp Leu Lys Ile Thr 
    210                 215                 220                 


Met Asn Arg Asp Glu Ile Phe Gln Val Leu Val Val Asp Pro Met Met 
225                 230                 235                 240 


Gly Ala Ile Asp Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Lys Trp 
                245                 250                 255     


Val Pro Asn Lys Lys Phe Glu Asn Thr Ile Gln Gln Met Tyr Ile Arg 
            260                 265                 270         


Arg Glu Ala Val Met Lys Ser Leu Ile Lys Glu His Lys Lys Arg Ile 
        275                 280                 285             


Ala Ser Gly Glu Lys Leu Asn Ser Tyr Ile Asp Tyr Leu Leu Ser Glu 
    290                 295                 300                 


Ala Gln Thr Leu Thr Asp Gln Gln Leu Leu Met Ser Leu Trp Glu Pro 
305                 310                 315                 320 


Ile Ile Glu Ser Ser Asp Thr Thr Met Val Thr Thr Glu Trp Ala Met 
                325                 330                 335     


Tyr Glu Leu Ala Lys Asn Pro Lys Leu Gln Asp Arg Leu Tyr Arg Asp 
            340                 345                 350         


Ile Lys Ser Val Cys Gly Ser Glu Lys Ile Thr Glu Glu His Leu Ser 
        355                 360                 365             


Gln Leu Pro Tyr Ile Thr Ala Ile Phe His Glu Thr Leu Arg Arg His 
    370                 375                 380                 


Ser Pro Val Pro Ile Ile Pro Leu Arg His Val His Glu Asp Thr Val 
385                 390                 395                 400 


Leu Gly Gly Tyr His Val Pro Ala Gly Thr Glu Leu Ala Val Asn Ile 
                405                 410                 415     


Tyr Gly Cys Asn Met Asp Lys Asn Val Trp Glu Asn Pro Glu Glu Trp 
            420                 425                 430         


Asn Pro Glu Arg Phe Met Lys Glu Asn Glu Thr Ile Asp Phe Gln Lys 
        435                 440                 445             


Thr Met Ala Phe Gly Gly Gly Lys Arg Val Cys Ala Gly Ser Leu Gln 
    450                 455                 460                 


Ala Leu Leu Thr Ala Ser Ile Gly Ile Gly Arg Met Val Gln Glu Phe 
465                 470                 475                 480 


Glu Trp Lys Leu Lys Asp Met Thr Gln Glu Glu Val Asn Thr Ile Gly 
                485                 490                 495     


Leu Thr Thr Gln Met Leu Arg Pro Leu Arg Ala Ile Ile Lys Pro Arg 
            500                 505                 510         


Ile 
    


<210>  8
<211>  509
<212>  PRT
<213>  Arabidopsis thaliana

<400>  8

Met Ala Phe Phe Ser Met Ile Ser Ile Leu Leu Gly Phe Val Ile Ser 
1               5                   10                  15      


Ser Phe Ile Phe Ile Phe Phe Phe Lys Lys Leu Leu Ser Phe Ser Arg 
            20                  25                  30          


Lys Asn Met Ser Glu Val Ser Thr Leu Pro Ser Val Pro Val Val Pro 
        35                  40                  45              


Gly Phe Pro Val Ile Gly Asn Leu Leu Gln Leu Lys Glu Lys Lys Pro 
    50                  55                  60                  


His Lys Thr Phe Thr Arg Trp Ser Glu Ile Tyr Gly Pro Ile Tyr Ser 
65                  70                  75                  80  


Ile Lys Met Gly Ser Ser Ser Leu Ile Val Leu Asn Ser Thr Glu Thr 
                85                  90                  95      


Ala Lys Glu Ala Met Val Thr Arg Phe Ser Ser Ile Ser Thr Arg Lys 
            100                 105                 110         


Leu Ser Asn Ala Leu Thr Val Leu Thr Cys Asp Lys Ser Met Val Ala 
        115                 120                 125             


Thr Ser Asp Tyr Asp Asp Phe His Lys Leu Val Lys Arg Cys Leu Leu 
    130                 135                 140                 


Asn Gly Leu Leu Gly Ala Asn Ala Gln Lys Arg Lys Arg His Tyr Arg 
145                 150                 155                 160 


Asp Ala Leu Ile Glu Asn Val Ser Ser Lys Leu His Ala His Ala Arg 
                165                 170                 175     


Asp His Pro Gln Glu Pro Val Asn Phe Arg Ala Ile Phe Glu His Glu 
            180                 185                 190         


Leu Phe Gly Val Ala Leu Lys Gln Ala Phe Gly Lys Asp Val Glu Ser 
        195                 200                 205             


Ile Tyr Val Lys Glu Leu Gly Val Thr Leu Ser Lys Asp Glu Ile Phe 
    210                 215                 220                 


Lys Val Leu Val His Asp Met Met Glu Gly Ala Ile Asp Val Asp Trp 
225                 230                 235                 240 


Arg Asp Phe Phe Pro Tyr Leu Lys Trp Ile Pro Asn Lys Ser Phe Glu 
                245                 250                 255     


Ala Arg Ile Gln Gln Lys His Lys Arg Arg Leu Ala Val Met Asn Ala 
            260                 265                 270         


Leu Ile Gln Asp Arg Leu Lys Gln Asn Gly Ser Glu Ser Asp Asp Asp 
        275                 280                 285             


Cys Tyr Leu Asn Phe Leu Met Ser Glu Ala Lys Thr Leu Thr Lys Glu 
    290                 295                 300                 


Gln Ile Ala Ile Leu Val Trp Glu Thr Ile Ile Glu Thr Ala Asp Thr 
305                 310                 315                 320 


Thr Leu Val Thr Thr Glu Trp Ala Ile Tyr Glu Leu Ala Lys His Pro 
                325                 330                 335     


Ser Val Gln Asp Arg Leu Cys Lys Glu Ile Gln Asn Val Cys Gly Gly 
            340                 345                 350         


Glu Lys Phe Lys Glu Glu Gln Leu Ser Gln Val Pro Tyr Leu Asn Gly 
        355                 360                 365             


Val Phe His Glu Thr Leu Arg Lys Tyr Ser Pro Ala Pro Leu Val Pro 
    370                 375                 380                 


Ile Arg Tyr Ala His Glu Asp Thr Gln Ile Gly Gly Tyr His Val Pro 
385                 390                 395                 400 


Ala Gly Ser Glu Ile Ala Ile Asn Ile Tyr Gly Cys Asn Met Asp Lys 
                405                 410                 415     


Lys Arg Trp Glu Arg Pro Glu Asp Trp Trp Pro Glu Arg Phe Leu Asp 
            420                 425                 430         


Asp Gly Lys Tyr Glu Thr Ser Asp Leu His Lys Thr Met Ala Phe Gly 
        435                 440                 445             


Ala Gly Lys Arg Val Cys Ala Gly Ala Leu Gln Ala Ser Leu Met Ala 
    450                 455                 460                 


Gly Ile Ala Ile Gly Arg Leu Val Gln Glu Phe Glu Trp Lys Leu Arg 
465                 470                 475                 480 


Asp Gly Glu Glu Glu Asn Val Asp Thr Tyr Gly Leu Thr Ser Gln Lys 
                485                 490                 495     


Leu Tyr Pro Leu Met Ala Ile Ile Asn Pro Arg Arg Ser 
            500                 505                 


<210>  9
<211>  525
<212>  PRT
<213>  Fusarium fujikuroi

<400>  9

Met Ser Lys Ser Asn Ser Met Asn Ser Thr Ser His Glu Thr Leu Phe 
1               5                   10                  15      


Gln Gln Leu Val Leu Gly Leu Asp Arg Met Pro Leu Met Asp Val His 
            20                  25                  30          


Trp Leu Ile Tyr Val Ala Phe Gly Ala Trp Leu Cys Ser Tyr Val Ile 
        35                  40                  45              


His Val Leu Ser Ser Ser Ser Thr Val Lys Val Pro Val Val Gly Tyr 
    50                  55                  60                  


Arg Ser Val Phe Glu Pro Thr Trp Leu Leu Arg Leu Arg Phe Val Trp 
65                  70                  75                  80  


Glu Gly Gly Ser Ile Ile Gly Gln Gly Tyr Asn Lys Phe Lys Asp Ser 
                85                  90                  95      


Ile Phe Gln Val Arg Lys Leu Gly Thr Asp Ile Val Ile Ile Pro Pro 
            100                 105                 110         


Asn Tyr Ile Asp Glu Val Arg Lys Leu Ser Gln Asp Lys Thr Arg Ser 
        115                 120                 125             


Val Glu Pro Phe Ile Asn Asp Phe Ala Gly Gln Tyr Thr Arg Gly Met 
    130                 135                 140                 


Val Phe Leu Gln Ser Asp Leu Gln Asn Arg Val Ile Gln Gln Arg Leu 
145                 150                 155                 160 


Thr Pro Lys Leu Val Ser Leu Thr Lys Val Met Lys Glu Glu Leu Asp 
                165                 170                 175     


Tyr Ala Leu Thr Lys Glu Met Pro Asp Met Lys Asn Asp Glu Trp Val 
            180                 185                 190         


Glu Val Asp Ile Ser Ser Ile Met Val Arg Leu Ile Ser Arg Ile Ser 
        195                 200                 205             


Ala Arg Val Phe Leu Gly Pro Glu His Cys Arg Asn Gln Glu Trp Leu 
    210                 215                 220                 


Thr Thr Thr Ala Glu Tyr Ser Glu Ser Leu Phe Ile Thr Gly Phe Ile 
225                 230                 235                 240 


Leu Arg Val Val Pro His Ile Leu Arg Pro Phe Ile Ala Pro Leu Leu 
                245                 250                 255     


Pro Ser Tyr Arg Thr Leu Leu Arg Asn Val Ser Ser Gly Arg Arg Val 
            260                 265                 270         


Ile Gly Asp Ile Ile Arg Ser Gln Gln Gly Asp Gly Asn Glu Asp Ile 
        275                 280                 285             


Leu Ser Trp Met Arg Asp Ala Ala Thr Gly Glu Glu Lys Gln Ile Asp 
    290                 295                 300                 


Asn Ile Ala Gln Arg Met Leu Ile Leu Ser Leu Ala Ser Ile His Thr 
305                 310                 315                 320 


Thr Ala Met Thr Met Thr His Ala Met Tyr Asp Leu Cys Ala Cys Pro 
                325                 330                 335     


Glu Tyr Ile Glu Pro Leu Arg Asp Glu Val Lys Ser Val Val Gly Ala 
            340                 345                 350         


Ser Gly Trp Asp Lys Thr Ala Leu Asn Arg Phe His Lys Leu Asp Ser 
        355                 360                 365             


Phe Leu Lys Glu Ser Gln Arg Phe Asn Pro Val Phe Leu Leu Thr Phe 
    370                 375                 380                 


Asn Arg Ile Tyr His Gln Ser Met Thr Leu Ser Asp Gly Thr Asn Ile 
385                 390                 395                 400 


Pro Ser Gly Thr Arg Ile Ala Val Pro Ser His Ala Met Leu Gln Asp 
                405                 410                 415     


Ser Ala His Val Pro Gly Pro Thr Pro Pro Thr Glu Phe Asp Gly Phe 
            420                 425                 430         


Arg Tyr Ser Lys Ile Arg Ser Asp Ser Asn Tyr Ala Gln Lys Tyr Leu 
        435                 440                 445             


Phe Ser Met Thr Asp Ser Ser Asn Met Ala Phe Gly Tyr Gly Lys Tyr 
    450                 455                 460                 


Ala Cys Pro Gly Arg Phe Tyr Ala Ser Asn Glu Met Lys Leu Thr Leu 
465                 470                 475                 480 


Ala Ile Leu Leu Leu Gln Phe Glu Phe Lys Leu Pro Asp Gly Lys Gly 
                485                 490                 495     


Arg Pro Arg Asn Ile Thr Ile Asp Ser Asp Met Ile Pro Asp Pro Arg 
            500                 505                 510         


Ala Arg Leu Cys Val Arg Lys Arg Ser Leu Arg Asp Glu 
        515                 520                 525 


<210>  10
<211>  499
<212>  PRT
<213>  Trametes versicolor

<400>  10

Met Glu Asp Pro Thr Val Leu Tyr Ala Cys Leu Ala Ile Ala Val Ala 
1               5                   10                  15      


Thr Phe Val Val Arg Trp Tyr Arg Asp Pro Leu Arg Ser Ile Pro Thr 
            20                  25                  30          


Val Gly Gly Ser Asp Leu Pro Ile Leu Ser Tyr Ile Gly Ala Leu Arg 
        35                  40                  45              


Trp Thr Arg Arg Gly Arg Glu Ile Leu Gln Glu Gly Tyr Asp Gly Tyr 
    50                  55                  60                  


Arg Gly Ser Thr Phe Lys Ile Ala Met Leu Asp Arg Trp Ile Val Ile 
65                  70                  75                  80  


Ala Asn Gly Pro Lys Leu Ala Asp Glu Val Arg Arg Arg Pro Asp Glu 
                85                  90                  95      


Glu Leu Asn Phe Met Asp Gly Leu Gly Ala Phe Val Gln Thr Lys Tyr 
            100                 105                 110         


Thr Leu Gly Glu Ala Ile His Asn Asp Pro Tyr His Val Asp Ile Ile 
        115                 120                 125             


Arg Glu Lys Leu Thr Arg Gly Leu Pro Ala Val Leu Pro Asp Val Ile 
    130                 135                 140                 


Glu Glu Leu Thr Leu Ala Val Arg Gln Tyr Ile Pro Thr Glu Gly Asp 
145                 150                 155                 160 


Glu Trp Val Ser Val Asn Cys Ser Lys Ala Ala Arg Asp Ile Val Ala 
                165                 170                 175     


Arg Ala Ser Asn Arg Val Phe Val Gly Leu Pro Ala Cys Arg Asn Gln 
            180                 185                 190         


Gly Tyr Leu Asp Leu Ala Ile Asp Phe Thr Leu Ser Val Val Lys Asp 
        195                 200                 205             


Arg Ala Ile Ile Asn Met Phe Pro Glu Leu Leu Lys Pro Ile Val Gly 
    210                 215                 220                 


Arg Val Val Gly Asn Ala Thr Arg Asn Val Arg Arg Ala Val Pro Phe 
225                 230                 235                 240 


Val Ala Pro Leu Val Glu Glu Arg Arg Arg Leu Met Glu Glu Tyr Gly 
                245                 250                 255     


Glu Asp Trp Ser Glu Lys Pro Asn Asp Met Leu Gln Trp Ile Met Asp 
            260                 265                 270         


Glu Ala Ala Ser Arg Asp Ser Ser Val Lys Ala Ile Ala Glu Arg Leu 
        275                 280                 285             


Leu Met Val Asn Phe Ala Ala Ile His Thr Ser Ser Asn Thr Ile Thr 
    290                 295                 300                 


His Ala Leu Tyr His Leu Ala Glu Met Pro Glu Thr Leu Gln Pro Leu 
305                 310                 315                 320 


Arg Glu Glu Ile Glu Pro Leu Val Lys Glu Glu Gly Trp Thr Lys Ala 
                325                 330                 335     


Ala Met Gly Lys Met Trp Trp Leu Asp Ser Phe Leu Arg Glu Ser Gln 
            340                 345                 350         


Arg Tyr Asn Gly Ile Asn Ile Val Ser Leu Thr Arg Met Ala Asp Lys 
        355                 360                 365             


Asp Ile Thr Leu Ser Asp Gly Thr Phe Leu Pro Lys Gly Thr Leu Val 
    370                 375                 380                 


Ala Val Pro Ala Tyr Ser Thr His Arg Asp Asp Ala Val Tyr Ala Asp 
385                 390                 395                 400 


Ala Leu Val Phe Asp Pro Phe Arg Phe Ser Arg Met Arg Ala Arg Glu 
                405                 410                 415     


Gly Glu Gly Thr Lys His Gln Phe Val Asn Thr Ser Val Glu Tyr Val 
            420                 425                 430         


Pro Phe Gly His Gly Lys His Ala Cys Pro Gly Arg Phe Phe Ala Ala 
        435                 440                 445             


Asn Glu Leu Lys Ala Met Leu Ala Tyr Ile Val Leu Asn Tyr Asp Val 
    450                 455                 460                 


Lys Leu Pro Gly Asp Gly Lys Arg Pro Leu Asn Met Tyr Trp Gly Pro 
465                 470                 475                 480 


Thr Val Leu Pro Ala Pro Ala Gly Gln Val Leu Phe Arg Lys Arg Gln 
                485                 490                 495     


Val Ser Leu 
            


<210>  11
<211>  1678
<212>  DNA
<213>  Stevia rebaudiana

<400>  11
aaacaaagaa tgattcaagt tctaacaccg atccttctct tcctcatttt cttcgttttc       60

tggaaggttt acaagcacca gaaaaccaaa atcaatcttc caccgggaag cttcggatgg      120

ccatttctgg gcgaaactct ggcactccta cgtgcaggtt gggactcaga gccggagaga      180

tttgttcgtg aacggatcaa gaaacacgga agtcctctag tgtttaagac gtcgttgttt      240

ggcgaccgtt ttgcggtgtt gtgtggacct gccggaaaca agttcctgtt ctgcaacgag      300

aacaagctgg tggcgtcgtg gtggccggtt ccggtgagga agcttttcgg caagtctctg      360

ctcacgattc gtggtgatga agctaagtgg atgaggaaga tgttgttatc gtatctcggt      420

cctgatgctt tcgcaactca ttatgccgtc accatggacg tcgtcacccg tcggcatatc      480

gacgttcatt ggcgagggaa ggaagaggtg aacgtattcc aaaccgttaa gttatatgcc      540

tttgagcttg catgtcgttt attcatgaac ctagacgacc caaaccacat tgcaaaactc      600

ggttccttgt tcaacatttt cttgaaaggc atcattgagc ttccaatcga cgtcccaggg      660

acacgatttt atagctccaa aaaagcagca gcagctatca ggattgaact aaaaaaattg      720

attaaagcaa gaaaactgga actgaaagaa gggaaggcat catcttcaca agacctctta      780

tcacatttgc ttacatctcc agatgaaaat ggtatgtttc taaccgaaga agagattgta      840

gacaacatct tgttactact ctttgcgggt catgatacct cggctctttc aatcactttg      900

ctcatgaaga ctcttggcga acattctgat gtttatgaca aggtgttaaa agagcaacta      960

gagatatcga agacgaaaga agcatgggag tccctgaaat gggaggacat acaaaagatg     1020

aaatactcct ggagtgttat atgtgaagtc atgagactaa atccacctgt tataggaacc     1080

tatagagagg cccttgtgga tattgattat gcgggttata ccatccccaa aggatggaag     1140

ctgcactgga gtgctgtatc gacacaaagg gacgaggcta actttgaaga cgtaacacgt     1200

tttgacccat cacggtttga aggcgcagga ccgactccat tcacctttgt tccgtttgga     1260

ggggggccta gaatgtgttt agggaaagaa tttgctcgat tggaagtact tgcgtttctt     1320

cacaatattg tcaccaattt caaatgggac ctgttgatac ctgatgagaa aatagaatat     1380

gatcccatgg ctaccccagc aaaggggctt ccaattcgtc ttcatcccca tcaagtttga     1440

ttacttcaag catgaatcag tgatgtgaag gtaaaccata atggatctta ttggtagtta     1500

cagattatgt gtttttatgg catgaagaag ttatgataaa taaaattgtg ttattctaca     1560

acttatgtaa tttgtgcctg taagtaactg aatctattaa tgttttatgt gacatgaaac     1620

ataaatgtat aattagtaaa ttttctgctc aaaaaaaaaa aaaaaaaaaa aaaaaaaa       1678


<210>  12
<211>  476
<212>  PRT
<213>  Stevia rebaudiana

<400>  12

Met Ile Gln Val Leu Thr Pro Ile Leu Leu Phe Leu Ile Phe Phe Val 
1               5                   10                  15      


Phe Trp Lys Val Tyr Lys His Gln Lys Thr Lys Ile Asn Leu Pro Pro 
            20                  25                  30          


Gly Ser Phe Gly Trp Pro Phe Leu Gly Glu Thr Leu Ala Leu Leu Arg 
        35                  40                  45              


Ala Gly Trp Asp Ser Glu Pro Glu Arg Phe Val Arg Glu Arg Ile Lys 
    50                  55                  60                  


Lys His Gly Ser Pro Leu Val Phe Lys Thr Ser Leu Phe Gly Asp Arg 
65                  70                  75                  80  


Phe Ala Val Leu Cys Gly Pro Ala Gly Asn Lys Phe Leu Phe Cys Asn 
                85                  90                  95      


Glu Asn Lys Leu Val Ala Ser Trp Trp Pro Val Pro Val Arg Lys Leu 
            100                 105                 110         


Phe Gly Lys Ser Leu Leu Thr Ile Arg Gly Asp Glu Ala Lys Trp Met 
        115                 120                 125             


Arg Lys Met Leu Leu Ser Tyr Leu Gly Pro Asp Ala Phe Ala Thr His 
    130                 135                 140                 


Tyr Ala Val Thr Met Asp Val Val Thr Arg Arg His Ile Asp Val His 
145                 150                 155                 160 


Trp Arg Gly Lys Glu Glu Val Asn Val Phe Gln Thr Val Lys Leu Tyr 
                165                 170                 175     


Ala Phe Glu Leu Ala Cys Arg Leu Phe Met Asn Leu Asp Asp Pro Asn 
            180                 185                 190         


His Ile Ala Lys Leu Gly Ser Leu Phe Asn Ile Phe Leu Lys Gly Ile 
        195                 200                 205             


Ile Glu Leu Pro Ile Asp Val Pro Gly Thr Arg Phe Tyr Ser Ser Lys 
    210                 215                 220                 


Lys Ala Ala Ala Ala Ile Arg Ile Glu Leu Lys Lys Leu Ile Lys Ala 
225                 230                 235                 240 


Arg Lys Leu Glu Leu Lys Glu Gly Lys Ala Ser Ser Ser Gln Asp Leu 
                245                 250                 255     


Leu Ser His Leu Leu Thr Ser Pro Asp Glu Asn Gly Met Phe Leu Thr 
            260                 265                 270         


Glu Glu Glu Ile Val Asp Asn Ile Leu Leu Leu Leu Phe Ala Gly His 
        275                 280                 285             


Asp Thr Ser Ala Leu Ser Ile Thr Leu Leu Met Lys Thr Leu Gly Glu 
    290                 295                 300                 


His Ser Asp Val Tyr Asp Lys Val Leu Lys Glu Gln Leu Glu Ile Ser 
305                 310                 315                 320 


Lys Thr Lys Glu Ala Trp Glu Ser Leu Lys Trp Glu Asp Ile Gln Lys 
                325                 330                 335     


Met Lys Tyr Ser Trp Ser Val Ile Cys Glu Val Met Arg Leu Asn Pro 
            340                 345                 350         


Pro Val Ile Gly Thr Tyr Arg Glu Ala Leu Val Asp Ile Asp Tyr Ala 
        355                 360                 365             


Gly Tyr Thr Ile Pro Lys Gly Trp Lys Leu His Trp Ser Ala Val Ser 
    370                 375                 380                 


Thr Gln Arg Asp Glu Ala Asn Phe Glu Asp Val Thr Arg Phe Asp Pro 
385                 390                 395                 400 


Ser Arg Phe Glu Gly Ala Gly Pro Thr Pro Phe Thr Phe Val Pro Phe 
                405                 410                 415     


Gly Gly Gly Pro Arg Met Cys Leu Gly Lys Glu Phe Ala Arg Leu Glu 
            420                 425                 430         


Val Leu Ala Phe Leu His Asn Ile Val Thr Asn Phe Lys Trp Asp Leu 
        435                 440                 445             


Leu Ile Pro Asp Glu Lys Ile Glu Tyr Asp Pro Met Ala Thr Pro Ala 
    450                 455                 460                 


Lys Gly Leu Pro Ile Arg Leu His Pro His Gln Val 
465                 470                 475     


<210>  13
<211>  522
<212>  PRT
<213>  Stevia rebaudiana

<400>  13

Met Gly Leu Phe Pro Leu Glu Asp Ser Tyr Ala Leu Val Phe Glu Gly 
1               5                   10                  15      


Leu Ala Ile Thr Leu Ala Leu Tyr Tyr Leu Leu Ser Phe Ile Tyr Lys 
            20                  25                  30          


Thr Ser Lys Lys Thr Cys Thr Pro Pro Lys Ala Ser Gly Glu His Pro 
        35                  40                  45              


Ile Thr Gly His Leu Asn Leu Leu Ser Gly Ser Ser Gly Leu Pro His 
    50                  55                  60                  


Leu Ala Leu Ala Ser Leu Ala Asp Arg Cys Gly Pro Ile Phe Thr Ile 
65                  70                  75                  80  


Arg Leu Gly Ile Arg Arg Val Leu Val Val Ser Asn Trp Glu Ile Ala 
                85                  90                  95      


Lys Glu Ile Phe Thr Thr His Asp Leu Ile Val Ser Asn Arg Pro Lys 
            100                 105                 110         


Tyr Leu Ala Ala Lys Ile Leu Gly Phe Asn Tyr Val Ser Phe Ser Phe 
        115                 120                 125             


Ala Pro Tyr Gly Pro Tyr Trp Val Gly Ile Arg Lys Ile Ile Ala Thr 
    130                 135                 140                 


Lys Leu Met Ser Ser Ser Arg Leu Gln Lys Leu Gln Phe Val Arg Val 
145                 150                 155                 160 


Phe Glu Leu Glu Asn Ser Met Lys Ser Ile Arg Glu Ser Trp Lys Glu 
                165                 170                 175     


Lys Lys Asp Glu Glu Gly Lys Val Leu Val Glu Met Lys Lys Trp Phe 
            180                 185                 190         


Trp Glu Leu Asn Met Asn Ile Val Leu Arg Thr Val Ala Gly Lys Gln 
        195                 200                 205             


Tyr Thr Gly Thr Val Asp Asp Ala Asp Ala Lys Arg Ile Ser Glu Leu 
    210                 215                 220                 


Phe Arg Glu Trp Phe His Tyr Thr Gly Arg Phe Val Val Gly Asp Ala 
225                 230                 235                 240 


Phe Pro Phe Leu Gly Trp Leu Asp Leu Gly Gly Tyr Lys Lys Thr Met 
                245                 250                 255     


Glu Leu Val Ala Ser Arg Leu Asp Ser Met Val Ser Lys Trp Leu Asp 
            260                 265                 270         


Glu His Arg Lys Lys Gln Ala Asn Asp Asp Lys Lys Glu Asp Met Asp 
        275                 280                 285             


Phe Met Asp Ile Met Ile Ser Met Thr Glu Ala Asn Ser Pro Leu Glu 
    290                 295                 300                 


Gly Tyr Gly Thr Asp Thr Ile Ile Lys Thr Thr Cys Met Thr Leu Ile 
305                 310                 315                 320 


Val Ser Gly Val Asp Thr Thr Ser Ile Val Leu Thr Trp Ala Leu Ser 
                325                 330                 335     


Leu Leu Leu Asn Asn Arg Asp Thr Leu Lys Lys Ala Gln Glu Glu Leu 
            340                 345                 350         


Asp Met Cys Val Gly Lys Gly Arg Gln Val Asn Glu Ser Asp Leu Val 
        355                 360                 365             


Asn Leu Ile Tyr Leu Glu Ala Val Leu Lys Glu Ala Leu Arg Leu Tyr 
    370                 375                 380                 


Pro Ala Ala Phe Leu Gly Gly Pro Arg Ala Phe Leu Glu Asp Cys Thr 
385                 390                 395                 400 


Val Ala Gly Tyr Arg Ile Pro Lys Gly Thr Cys Leu Leu Ile Asn Met 
                405                 410                 415     


Trp Lys Leu His Arg Asp Pro Asn Ile Trp Ser Asp Pro Cys Glu Phe 
            420                 425                 430         


Lys Pro Glu Arg Phe Leu Thr Pro Asn Gln Lys Asp Val Asp Val Ile 
        435                 440                 445             


Gly Met Asp Phe Glu Leu Ile Pro Phe Gly Ala Gly Arg Arg Tyr Cys 
    450                 455                 460                 


Pro Gly Thr Arg Leu Ala Leu Gln Met Leu His Ile Val Leu Ala Thr 
465                 470                 475                 480 


Leu Leu Gln Asn Phe Glu Met Ser Thr Pro Asn Asp Ala Pro Val Asp 
                485                 490                 495     


Met Thr Ala Ser Val Gly Met Thr Asn Ala Lys Ala Ser Pro Leu Glu 
            500                 505                 510         


Val Leu Leu Ser Pro Arg Val Lys Trp Ser 
        515                 520         


<210>  14
<211>  476
<212>  PRT
<213>  Stevia rebaudiana

<400>  14

Met Ile Gln Val Leu Thr Pro Ile Leu Leu Phe Leu Ile Phe Phe Val 
1               5                   10                  15      


Phe Trp Lys Val Tyr Lys His Gln Lys Thr Lys Ile Asn Leu Pro Pro 
            20                  25                  30          


Gly Ser Phe Gly Trp Pro Phe Leu Gly Glu Thr Leu Ala Leu Leu Arg 
        35                  40                  45              


Ala Gly Trp Asp Ser Glu Pro Glu Arg Phe Val Arg Glu Arg Ile Lys 
    50                  55                  60                  


Lys His Gly Ser Pro Leu Val Phe Lys Thr Ser Leu Phe Gly Asp Arg 
65                  70                  75                  80  


Phe Ala Val Leu Cys Gly Pro Ala Gly Asn Lys Phe Leu Phe Cys Asn 
                85                  90                  95      


Glu Asn Lys Leu Val Ala Ser Trp Trp Pro Val Pro Val Arg Lys Leu 
            100                 105                 110         


Phe Gly Lys Ser Leu Leu Thr Ile Arg Gly Asp Glu Ala Lys Trp Met 
        115                 120                 125             


Arg Lys Met Leu Leu Ser Tyr Leu Gly Pro Asp Ala Phe Ala Thr His 
    130                 135                 140                 


Tyr Ala Val Thr Met Asp Val Val Thr Arg Arg His Ile Asp Val His 
145                 150                 155                 160 


Trp Arg Gly Lys Glu Glu Val Asn Val Phe Gln Thr Val Lys Leu Tyr 
                165                 170                 175     


Ala Phe Glu Leu Ala Cys Arg Leu Phe Met Asn Leu Asp Asp Pro Asn 
            180                 185                 190         


His Ile Ala Lys Leu Gly Ser Leu Phe Asn Ile Phe Leu Lys Gly Ile 
        195                 200                 205             


Ile Glu Leu Pro Ile Asp Val Pro Gly Thr Arg Phe Tyr Ser Ser Lys 
    210                 215                 220                 


Lys Ala Ala Ala Ala Ile Arg Ile Glu Leu Lys Lys Leu Ile Lys Ala 
225                 230                 235                 240 


Arg Lys Leu Glu Leu Lys Glu Gly Lys Ala Ser Ser Ser Gln Asp Leu 
                245                 250                 255     


Leu Ser His Leu Leu Thr Ser Pro Asp Glu Asn Gly Met Phe Leu Thr 
            260                 265                 270         


Glu Glu Glu Ile Val Asp Asn Ile Leu Leu Leu Leu Phe Ala Gly His 
        275                 280                 285             


Asp Thr Ser Ala Leu Ser Ile Thr Leu Leu Met Lys Thr Leu Gly Glu 
    290                 295                 300                 


His Ser Asp Val Tyr Asp Lys Val Leu Lys Glu Gln Leu Glu Ile Ser 
305                 310                 315                 320 


Lys Thr Lys Glu Ala Trp Glu Ser Leu Lys Trp Glu Asp Ile Gln Lys 
                325                 330                 335     


Met Lys Tyr Ser Trp Ser Val Ile Cys Glu Val Met Arg Leu Asn Pro 
            340                 345                 350         


Pro Val Ile Gly Thr Tyr Arg Glu Ala Leu Val Asp Ile Asp Tyr Ala 
        355                 360                 365             


Gly Tyr Thr Ile Pro Lys Gly Trp Lys Leu His Trp Ser Ala Val Ser 
    370                 375                 380                 


Thr Gln Arg Asp Glu Ala Asn Phe Glu Asp Val Thr Arg Phe Asp Pro 
385                 390                 395                 400 


Ser Arg Phe Glu Gly Ala Gly Pro Thr Pro Phe Thr Phe Val Pro Phe 
                405                 410                 415     


Gly Gly Gly Pro Arg Met Cys Leu Gly Lys Glu Phe Ala Arg Leu Glu 
            420                 425                 430         


Val Leu Ala Phe Leu His Asn Ile Val Thr Asn Phe Lys Trp Asp Leu 
        435                 440                 445             


Leu Ile Pro Asp Glu Lys Ile Glu Tyr Asp Pro Met Ala Thr Pro Ala 
    450                 455                 460                 


Lys Gly Leu Pro Ile Arg Leu His Pro His Gln Val 
465                 470                 475     


<210>  15
<211>  525
<212>  PRT
<213>  Arabidopsis thaliana

<400>  15

Met Glu Ser Leu Val Val His Thr Val Asn Ala Ile Trp Cys Ile Val 
1               5                   10                  15      


Ile Val Gly Ile Phe Ser Val Gly Tyr His Val Tyr Gly Arg Ala Val 
            20                  25                  30          


Val Glu Gln Trp Arg Met Arg Arg Ser Leu Lys Leu Gln Gly Val Lys 
        35                  40                  45              


Gly Pro Pro Pro Ser Ile Phe Asn Gly Asn Val Ser Glu Met Gln Arg 
    50                  55                  60                  


Ile Gln Ser Glu Ala Lys His Cys Ser Gly Asp Asn Ile Ile Ser His 
65                  70                  75                  80  


Asp Tyr Ser Ser Ser Leu Phe Pro His Phe Asp His Trp Arg Lys Gln 
                85                  90                  95      


Tyr Gly Arg Ile Tyr Thr Tyr Ser Thr Gly Leu Lys Gln His Leu Tyr 
            100                 105                 110         


Ile Asn His Pro Glu Met Val Lys Glu Leu Ser Gln Thr Asn Thr Leu 
        115                 120                 125             


Asn Leu Gly Arg Ile Thr His Ile Thr Lys Arg Leu Asn Pro Ile Leu 
    130                 135                 140                 


Gly Asn Gly Ile Ile Thr Ser Asn Gly Pro His Trp Ala His Gln Arg 
145                 150                 155                 160 


Arg Ile Ile Ala Tyr Glu Phe Thr His Asp Lys Ile Lys Gly Met Val 
                165                 170                 175     


Gly Leu Met Val Glu Ser Ala Met Pro Met Leu Asn Lys Trp Glu Glu 
            180                 185                 190         


Met Val Lys Arg Gly Gly Glu Met Gly Cys Asp Ile Arg Val Asp Glu 
        195                 200                 205             


Asp Leu Lys Asp Val Ser Ala Asp Val Ile Ala Lys Ala Cys Phe Gly 
    210                 215                 220                 


Ser Ser Phe Ser Lys Gly Lys Ala Ile Phe Ser Met Ile Arg Asp Leu 
225                 230                 235                 240 


Leu Thr Ala Ile Thr Lys Arg Ser Val Leu Phe Arg Phe Asn Gly Phe 
                245                 250                 255     


Thr Asp Met Val Phe Gly Ser Lys Lys His Gly Asp Val Asp Ile Asp 
            260                 265                 270         


Ala Leu Glu Met Glu Leu Glu Ser Ser Ile Trp Glu Thr Val Lys Glu 
        275                 280                 285             


Arg Glu Ile Glu Cys Lys Asp Thr His Lys Lys Asp Leu Met Gln Leu 
    290                 295                 300                 


Ile Leu Glu Gly Ala Met Arg Ser Cys Asp Gly Asn Leu Trp Asp Lys 
305                 310                 315                 320 


Ser Ala Tyr Arg Arg Phe Val Val Asp Asn Cys Lys Ser Ile Tyr Phe 
                325                 330                 335     


Ala Gly His Asp Ser Thr Ala Val Ser Val Ser Trp Cys Leu Met Leu 
            340                 345                 350         


Leu Ala Leu Asn Pro Ser Trp Gln Val Lys Ile Arg Asp Glu Ile Leu 
        355                 360                 365             


Ser Ser Cys Lys Asn Gly Ile Pro Asp Ala Glu Ser Ile Pro Asn Leu 
    370                 375                 380                 


Lys Thr Val Thr Met Val Ile Gln Glu Thr Met Arg Leu Tyr Pro Pro 
385                 390                 395                 400 


Ala Pro Ile Val Gly Arg Glu Ala Ser Lys Asp Ile Arg Leu Gly Asp 
                405                 410                 415     


Leu Val Val Pro Lys Gly Val Cys Ile Trp Thr Leu Ile Pro Ala Leu 
            420                 425                 430         


His Arg Asp Pro Glu Ile Trp Gly Pro Asp Ala Asn Asp Phe Lys Pro 
        435                 440                 445             


Glu Arg Phe Ser Glu Gly Ile Ser Lys Ala Cys Lys Tyr Pro Gln Ser 
    450                 455                 460                 


Tyr Ile Pro Phe Gly Leu Gly Pro Arg Thr Cys Val Gly Lys Asn Phe 
465                 470                 475                 480 


Gly Met Met Glu Val Lys Val Leu Val Ser Leu Ile Val Ser Lys Phe 
                485                 490                 495     


Ser Phe Thr Leu Ser Pro Thr Tyr Gln His Ser Pro Ser His Lys Leu 
            500                 505                 510         


Leu Val Glu Pro Gln His Gly Val Val Ile Arg Val Val 
        515                 520                 525 


<210>  16
<211>  526
<212>  PRT
<213>  Vitis vinifera

<400>  16

Met Tyr Phe Leu Leu Gln Tyr Leu Asn Ile Thr Thr Val Gly Val Phe 
1               5                   10                  15      


Ala Thr Leu Phe Leu Ser Tyr Cys Leu Leu Leu Trp Arg Ser Arg Ala 
            20                  25                  30          


Gly Asn Lys Lys Ile Ala Pro Glu Ala Ala Ala Ala Trp Pro Ile Ile 
        35                  40                  45              


Gly His Leu His Leu Leu Ala Gly Gly Ser His Gln Leu Pro His Ile 
    50                  55                  60                  


Thr Leu Gly Asn Met Ala Asp Lys Tyr Gly Pro Val Phe Thr Ile Arg 
65                  70                  75                  80  


Ile Gly Leu His Arg Ala Val Val Val Ser Ser Trp Glu Met Ala Lys 
                85                  90                  95      


Glu Cys Ser Thr Ala Asn Asp Gln Val Ser Ser Ser Arg Pro Glu Leu 
            100                 105                 110         


Leu Ala Ser Lys Leu Leu Gly Tyr Asn Tyr Ala Met Phe Gly Phe Ser 
        115                 120                 125             


Pro Tyr Gly Ser Tyr Trp Arg Glu Met Arg Lys Ile Ile Ser Leu Glu 
    130                 135                 140                 


Leu Leu Ser Asn Ser Arg Leu Glu Leu Leu Lys Asp Val Arg Ala Ser 
145                 150                 155                 160 


Glu Val Val Thr Ser Ile Lys Glu Leu Tyr Lys Leu Trp Ala Glu Lys 
                165                 170                 175     


Lys Asn Glu Ser Gly Leu Val Ser Val Glu Met Lys Gln Trp Phe Gly 
            180                 185                 190         


Asp Leu Thr Leu Asn Val Ile Leu Arg Met Val Ala Gly Lys Arg Tyr 
        195                 200                 205             


Phe Ser Ala Ser Asp Ala Ser Glu Asn Lys Gln Ala Gln Arg Cys Arg 
    210                 215                 220                 


Arg Val Phe Arg Glu Phe Phe His Leu Ser Gly Leu Phe Val Val Ala 
225                 230                 235                 240 


Asp Ala Ile Pro Phe Leu Gly Trp Leu Asp Trp Gly Arg His Glu Lys 
                245                 250                 255     


Thr Leu Lys Lys Thr Ala Ile Glu Met Asp Ser Ile Ala Gln Glu Trp 
            260                 265                 270         


Leu Glu Glu His Arg Arg Arg Lys Asp Ser Gly Asp Asp Asn Ser Thr 
        275                 280                 285             


Gln Asp Phe Met Asp Val Met Gln Ser Val Leu Asp Gly Lys Asn Leu 
    290                 295                 300                 


Gly Gly Tyr Asp Ala Asp Thr Ile Asn Lys Ala Thr Cys Leu Thr Leu 
305                 310                 315                 320 


Ile Ser Gly Gly Ser Asp Thr Thr Val Val Ser Leu Thr Trp Ala Leu 
                325                 330                 335     


Ser Leu Val Leu Asn Asn Arg Asp Thr Leu Lys Lys Ala Gln Glu Glu 
            340                 345                 350         


Leu Asp Ile Gln Val Gly Lys Glu Arg Leu Val Asn Glu Gln Asp Ile 
        355                 360                 365             


Ser Lys Leu Val Tyr Leu Gln Ala Ile Val Lys Glu Thr Leu Arg Leu 
    370                 375                 380                 


Tyr Pro Pro Gly Pro Leu Gly Gly Leu Arg Gln Phe Thr Glu Asp Cys 
385                 390                 395                 400 


Thr Leu Gly Gly Tyr His Val Ser Lys Gly Thr Arg Leu Ile Met Asn 
                405                 410                 415     


Leu Ser Lys Ile Gln Lys Asp Pro Arg Ile Trp Ser Asp Pro Thr Glu 
            420                 425                 430         


Phe Gln Pro Glu Arg Phe Leu Thr Thr His Lys Asp Val Asp Pro Arg 
        435                 440                 445             


Gly Lys His Phe Glu Phe Ile Pro Phe Gly Ala Gly Arg Arg Ala Cys 
    450                 455                 460                 


Pro Gly Ile Thr Phe Gly Leu Gln Val Leu His Leu Thr Leu Ala Ser 
465                 470                 475                 480 


Phe Leu His Ala Phe Glu Phe Ser Thr Pro Ser Asn Glu Gln Val Asn 
                485                 490                 495     


Met Arg Glu Ser Leu Gly Leu Thr Asn Met Lys Ser Thr Pro Leu Glu 
            500                 505                 510         


Val Leu Ile Ser Pro Arg Leu Ser Ser Cys Ser Leu Tyr Asn 
        515                 520                 525     


<210>  17
<211>  479
<212>  PRT
<213>  Medicago truncatula

<400>  17

Met Glu Pro Asn Phe Tyr Leu Ser Leu Leu Leu Leu Phe Val Thr Phe 
1               5                   10                  15      


Ile Ser Leu Ser Leu Phe Phe Ile Phe Tyr Lys Gln Lys Ser Pro Leu 
            20                  25                  30          


Asn Leu Pro Pro Gly Lys Met Gly Tyr Pro Ile Ile Gly Glu Ser Leu 
        35                  40                  45              


Glu Phe Leu Ser Thr Gly Trp Lys Gly His Pro Glu Lys Phe Ile Phe 
    50                  55                  60                  


Asp Arg Met Arg Lys Tyr Ser Ser Glu Leu Phe Lys Thr Ser Ile Val 
65                  70                  75                  80  


Gly Glu Ser Thr Val Val Cys Cys Gly Ala Ala Ser Asn Lys Phe Leu 
                85                  90                  95      


Phe Ser Asn Glu Asn Lys Leu Val Thr Ala Trp Trp Pro Asp Ser Val 
            100                 105                 110         


Asn Lys Ile Phe Pro Thr Thr Ser Leu Asp Ser Asn Leu Lys Glu Glu 
        115                 120                 125             


Ser Ile Lys Met Arg Lys Leu Leu Pro Gln Phe Phe Lys Pro Glu Ala 
    130                 135                 140                 


Leu Gln Arg Tyr Val Gly Val Met Asp Val Ile Ala Gln Arg His Phe 
145                 150                 155                 160 


Val Thr His Trp Asp Asn Lys Asn Glu Ile Thr Val Tyr Pro Leu Ala 
                165                 170                 175     


Lys Arg Tyr Thr Phe Leu Leu Ala Cys Arg Leu Phe Met Ser Val Glu 
            180                 185                 190         


Asp Glu Asn His Val Ala Lys Phe Ser Asp Pro Phe Gln Leu Ile Ala 
        195                 200                 205             


Ala Gly Ile Ile Ser Leu Pro Ile Asp Leu Pro Gly Thr Pro Phe Asn 
    210                 215                 220                 


Lys Ala Ile Lys Ala Ser Asn Phe Ile Arg Lys Glu Leu Ile Lys Ile 
225                 230                 235                 240 


Ile Lys Gln Arg Arg Val Asp Leu Ala Glu Gly Thr Ala Ser Pro Thr 
                245                 250                 255     


Gln Asp Ile Leu Ser His Met Leu Leu Thr Ser Asp Glu Asn Gly Lys 
            260                 265                 270         


Ser Met Asn Glu Leu Asn Ile Ala Asp Lys Ile Leu Gly Leu Leu Ile 
        275                 280                 285             


Gly Gly His Asp Thr Ala Ser Val Ala Cys Thr Phe Leu Val Lys Tyr 
    290                 295                 300                 


Leu Gly Glu Leu Pro His Ile Tyr Asp Lys Val Tyr Gln Glu Gln Met 
305                 310                 315                 320 


Glu Ile Ala Lys Ser Lys Pro Ala Gly Glu Leu Leu Asn Trp Asp Asp 
                325                 330                 335     


Leu Lys Lys Met Lys Tyr Ser Trp Asn Val Ala Cys Glu Val Met Arg 
            340                 345                 350         


Leu Ser Pro Pro Leu Gln Gly Gly Phe Arg Glu Ala Ile Thr Asp Phe 
        355                 360                 365             


Met Phe Asn Gly Phe Ser Ile Pro Lys Gly Trp Lys Leu Tyr Trp Ser 
    370                 375                 380                 


Ala Asn Ser Thr His Lys Asn Ala Glu Cys Phe Pro Met Pro Glu Lys 
385                 390                 395                 400 


Phe Asp Pro Thr Arg Phe Glu Gly Asn Gly Pro Ala Pro Tyr Thr Phe 
                405                 410                 415     


Val Pro Phe Gly Gly Gly Pro Arg Met Cys Pro Gly Lys Glu Tyr Ala 
            420                 425                 430         


Arg Leu Glu Ile Leu Val Phe Met His Asn Leu Val Lys Arg Phe Lys 
        435                 440                 445             


Trp Glu Lys Val Ile Pro Asp Glu Lys Ile Ile Val Asp Pro Phe Pro 
    450                 455                 460                 


Ile Pro Ala Lys Asp Leu Pro Ile Arg Leu Tyr Pro His Lys Ala 
465                 470                 475                 


<210>  18
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized Stevia rebaudiana KAHe1

<400>  18
atggaagcct cttacctata catttctatt ttgcttttac tggcatcata cctgttcacc       60

actcaactta gaaggaagag cgctaatcta ccaccaaccg tgtttccatc aataccaatc      120

attggacact tatacttact caaaaagcct ctttatagaa ctttagcaaa aattgccgct      180

aagtacggac caatactgca attacaactc ggctacagac gtgttctggt gatttcctca      240

ccatcagcag cagaagagtg ctttaccaat aacgatgtaa tcttcgcaaa tagacctaag      300

acattgtttg gcaaaatagt gggtggaaca tcccttggca gtttatccta cggcgatcaa      360

tggcgtaatc taaggagagt agcttctatc gaaatcctat cagttcatag gttgaacgaa      420

tttcatgata tcagagtgga tgagaacaga ttgttaatta gaaaacttag aagttcatct      480

tctcctgtta ctcttataac agtcttttat gctctaacat tgaacgtcat tatgagaatg      540

atctctggca aaagatattt cgacagtggg gatagagaat tggaggagga aggtaagaga      600

tttcgagaaa tcttagacga aacgttgctt ctagccggtg cttctaatgt tggcgactac      660

ttaccaatat tgaactggtt gggagttaag tctcttgaaa agaaattgat cgctttgcag      720

aaaaagagag atgacttttt ccagggtttg attgaacagg ttagaaaatc tcgtggtgct      780

aaagtaggca aaggtagaaa aacgatgatc gaactcttat tatctttgca agagtcagaa      840

cctgagtact atacagatgc tatgataaga tcttttgtcc taggtctgct ggctgcaggt      900

agtgatactt cagcgggcac tatggaatgg gccatgagct tactggtcaa tcacccacat      960

gtattgaaga aagctcaagc tgaaatcgat agagttatcg gtaataacag attgattgac     1020

gagtcagaca ttggaaatat cccttacatc gggtgtatta tcaatgaaac tctaagactc     1080

tatccagcag ggccattgtt gttcccacat gaaagttctg ccgactgcgt tatttccggt     1140

tacaatatac ctagaggtac aatgttaatc gtaaaccaat gggcgattca tcacgatcct     1200

aaagtctggg atgatcctga aacctttaaa cctgaaagat ttcaaggatt agaaggaact     1260

agagatggtt tcaaacttat gccattcggt tctgggagaa gaggatgtcc aggtgaaggt     1320

ttggcaataa ggctgttagg gatgacacta ggctcagtga tccaatgttt tgattgggag     1380

agagtaggag atgagatggt tgacatgaca gaaggtttgg gtgtcacact tcctaaggcc     1440

gttccattag ttgccaaatg taagccacgt tccgaaatga ctaatctcct atccgaactt     1500

taa                                                                   1503


<210>  19
<211>  500
<212>  PRT
<213>  Stevia rebaudiana

<400>  19

Met Glu Ala Ser Tyr Leu Tyr Ile Ser Ile Leu Leu Leu Leu Ala Ser 
1               5                   10                  15      


Tyr Leu Phe Thr Thr Gln Leu Arg Arg Lys Ser Ala Asn Leu Pro Pro 
            20                  25                  30          


Thr Val Phe Pro Ser Ile Pro Ile Ile Gly His Leu Tyr Leu Leu Lys 
        35                  40                  45              


Lys Pro Leu Tyr Arg Thr Leu Ala Lys Ile Ala Ala Lys Tyr Gly Pro 
    50                  55                  60                  


Ile Leu Gln Leu Gln Leu Gly Tyr Arg Arg Val Leu Val Ile Ser Ser 
65                  70                  75                  80  


Pro Ser Ala Ala Glu Glu Cys Phe Thr Asn Asn Asp Val Ile Phe Ala 
                85                  90                  95      


Asn Arg Pro Lys Thr Leu Phe Gly Lys Ile Val Gly Gly Thr Ser Leu 
            100                 105                 110         


Gly Ser Leu Ser Tyr Gly Asp Gln Trp Arg Asn Leu Arg Arg Val Ala 
        115                 120                 125             


Ser Ile Glu Ile Leu Ser Val His Arg Leu Asn Glu Phe His Asp Ile 
    130                 135                 140                 


Arg Val Asp Glu Asn Arg Leu Leu Ile Arg Lys Leu Arg Ser Ser Ser 
145                 150                 155                 160 


Ser Pro Val Thr Leu Ile Thr Val Phe Tyr Ala Leu Thr Leu Asn Val 
                165                 170                 175     


Ile Met Arg Met Ile Ser Gly Lys Arg Tyr Phe Asp Ser Gly Asp Arg 
            180                 185                 190         


Glu Leu Glu Glu Glu Gly Lys Arg Phe Arg Glu Ile Leu Asp Glu Thr 
        195                 200                 205             


Leu Leu Leu Ala Gly Ala Ser Asn Val Gly Asp Tyr Leu Pro Ile Leu 
    210                 215                 220                 


Asn Trp Leu Gly Val Lys Ser Leu Glu Lys Lys Leu Ile Ala Leu Gln 
225                 230                 235                 240 


Lys Lys Arg Asp Asp Phe Phe Gln Gly Leu Ile Glu Gln Val Arg Lys 
                245                 250                 255     


Ser Arg Gly Ala Lys Val Gly Lys Gly Arg Lys Thr Met Ile Glu Leu 
            260                 265                 270         


Leu Leu Ser Leu Gln Glu Ser Glu Pro Glu Tyr Tyr Thr Asp Ala Met 
        275                 280                 285             


Ile Arg Ser Phe Val Leu Gly Leu Leu Ala Ala Gly Ser Asp Thr Ser 
    290                 295                 300                 


Ala Gly Thr Met Glu Trp Ala Met Ser Leu Leu Val Asn His Pro His 
305                 310                 315                 320 


Val Leu Lys Lys Ala Gln Ala Glu Ile Asp Arg Val Ile Gly Asn Asn 
                325                 330                 335     


Arg Leu Ile Asp Glu Ser Asp Ile Gly Asn Ile Pro Tyr Ile Gly Cys 
            340                 345                 350         


Ile Ile Asn Glu Thr Leu Arg Leu Tyr Pro Ala Gly Pro Leu Leu Phe 
        355                 360                 365             


Pro His Glu Ser Ser Ala Asp Cys Val Ile Ser Gly Tyr Asn Ile Pro 
    370                 375                 380                 


Arg Gly Thr Met Leu Ile Val Asn Gln Trp Ala Ile His His Asp Pro 
385                 390                 395                 400 


Lys Val Trp Asp Asp Pro Glu Thr Phe Lys Pro Glu Arg Phe Gln Gly 
                405                 410                 415     


Leu Glu Gly Thr Arg Asp Gly Phe Lys Leu Met Pro Phe Gly Ser Gly 
            420                 425                 430         


Arg Arg Gly Cys Pro Gly Glu Gly Leu Ala Ile Arg Leu Leu Gly Met 
        435                 440                 445             


Thr Leu Gly Ser Val Ile Gln Cys Phe Asp Trp Glu Arg Val Gly Asp 
    450                 455                 460                 


Glu Met Val Asp Met Thr Glu Gly Leu Gly Val Thr Leu Pro Lys Ala 
465                 470                 475                 480 


Val Pro Leu Val Ala Lys Cys Lys Pro Arg Ser Glu Met Thr Asn Leu 
                485                 490                 495     


Leu Ser Glu Leu 
            500 


<210>  20
<211>  710
<212>  PRT
<213>  Stevia rebaudiana

<400>  20

Met Gln Ser Asp Ser Val Lys Val Ser Pro Phe Asp Leu Val Ser Ala 
1               5                   10                  15      


Ala Met Asn Gly Lys Ala Met Glu Lys Leu Asn Ala Ser Glu Ser Glu 
            20                  25                  30          


Asp Pro Thr Thr Leu Pro Ala Leu Lys Met Leu Val Glu Asn Arg Glu 
        35                  40                  45              


Leu Leu Thr Leu Phe Thr Thr Ser Phe Ala Val Leu Ile Gly Cys Leu 
    50                  55                  60                  


Val Phe Leu Met Trp Arg Arg Ser Ser Ser Lys Lys Leu Val Gln Asp 
65                  70                  75                  80  


Pro Val Pro Gln Val Ile Val Val Lys Lys Lys Glu Lys Glu Ser Glu 
                85                  90                  95      


Val Asp Asp Gly Lys Lys Lys Val Ser Ile Phe Tyr Gly Thr Gln Thr 
            100                 105                 110         


Gly Thr Ala Glu Gly Phe Ala Lys Ala Leu Val Glu Glu Ala Lys Val 
        115                 120                 125             


Arg Tyr Glu Lys Thr Ser Phe Lys Val Ile Asp Leu Asp Asp Tyr Ala 
    130                 135                 140                 


Ala Asp Asp Asp Glu Tyr Glu Glu Lys Leu Lys Lys Glu Ser Leu Ala 
145                 150                 155                 160 


Phe Phe Phe Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala 
                165                 170                 175     


Ala Asn Phe Tyr Lys Trp Phe Thr Glu Gly Asp Asp Lys Gly Glu Trp 
            180                 185                 190         


Leu Lys Lys Leu Gln Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln Tyr 
        195                 200                 205             


Glu His Phe Asn Lys Ile Ala Ile Val Val Asp Asp Lys Leu Thr Glu 
    210                 215                 220                 


Met Gly Ala Lys Arg Leu Val Pro Val Gly Leu Gly Asp Asp Asp Gln 
225                 230                 235                 240 


Cys Ile Glu Asp Asp Phe Thr Ala Trp Lys Glu Leu Val Trp Pro Glu 
                245                 250                 255     


Leu Asp Gln Leu Leu Arg Asp Glu Asp Asp Thr Ser Val Thr Thr Pro 
            260                 265                 270         


Tyr Thr Ala Ala Val Leu Glu Tyr Arg Val Val Tyr His Asp Lys Pro 
        275                 280                 285             


Ala Asp Ser Tyr Ala Glu Asp Gln Thr His Thr Asn Gly His Val Val 
    290                 295                 300                 


His Asp Ala Gln His Pro Ser Arg Ser Asn Val Ala Phe Lys Lys Glu 
305                 310                 315                 320 


Leu His Thr Ser Gln Ser Asp Arg Ser Cys Thr His Leu Glu Phe Asp 
                325                 330                 335     


Ile Ser His Thr Gly Leu Ser Tyr Glu Thr Gly Asp His Val Gly Val 
            340                 345                 350         


Tyr Ser Glu Asn Leu Ser Glu Val Val Asp Glu Ala Leu Lys Leu Leu 
        355                 360                 365             


Gly Leu Ser Pro Asp Thr Tyr Phe Ser Val His Ala Asp Lys Glu Asp 
    370                 375                 380                 


Gly Thr Pro Ile Gly Gly Ala Ser Leu Pro Pro Pro Phe Pro Pro Cys 
385                 390                 395                 400 


Thr Leu Arg Asp Ala Leu Thr Arg Tyr Ala Asp Val Leu Ser Ser Pro 
                405                 410                 415     


Lys Lys Val Ala Leu Leu Ala Leu Ala Ala His Ala Ser Asp Pro Ser 
            420                 425                 430         


Glu Ala Asp Arg Leu Lys Phe Leu Ala Ser Pro Ala Gly Lys Asp Glu 
        435                 440                 445             


Tyr Ala Gln Trp Ile Val Ala Asn Gln Arg Ser Leu Leu Glu Val Met 
    450                 455                 460                 


Gln Ser Phe Pro Ser Ala Lys Pro Pro Leu Gly Val Phe Phe Ala Ala 
465                 470                 475                 480 


Val Ala Pro Arg Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro 
                485                 490                 495     


Lys Met Ser Pro Asn Arg Ile His Val Thr Cys Ala Leu Val Tyr Glu 
            500                 505                 510         


Thr Thr Pro Ala Gly Arg Ile His Arg Gly Leu Cys Ser Thr Trp Met 
        515                 520                 525             


Lys Asn Ala Val Pro Leu Thr Glu Ser Pro Asp Cys Ser Gln Ala Ser 
    530                 535                 540                 


Ile Phe Val Arg Thr Ser Asn Phe Arg Leu Pro Val Asp Pro Lys Val 
545                 550                 555                 560 


Pro Val Ile Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly 
                565                 570                 575     


Phe Leu Gln Glu Arg Leu Ala Leu Lys Glu Ser Gly Thr Glu Leu Gly 
            580                 585                 590         


Ser Ser Ile Phe Phe Phe Gly Cys Arg Asn Arg Lys Val Asp Phe Ile 
        595                 600                 605             


Tyr Glu Asp Glu Leu Asn Asn Phe Val Glu Thr Gly Ala Leu Ser Glu 
    610                 615                 620                 


Leu Ile Val Ala Phe Ser Arg Glu Gly Thr Ala Lys Glu Tyr Val Gln 
625                 630                 635                 640 


His Lys Met Ser Gln Lys Ala Ser Asp Ile Trp Lys Leu Leu Ser Glu 
                645                 650                 655     


Gly Ala Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Lys Asp 
            660                 665                 670         


Val His Arg Thr Leu His Thr Ile Val Gln Glu Gln Gly Ser Leu Asp 
        675                 680                 685             


Ser Ser Lys Ala Glu Leu Tyr Val Lys Asn Leu Gln Met Ser Gly Arg 
    690                 695                 700                 


Tyr Leu Arg Asp Val Trp 
705                 710 


<210>  21
<211>  692
<212>  PRT
<213>  Arabidopsis thaliana

<400>  21

Met Thr Ser Ala Leu Tyr Ala Ser Asp Leu Phe Lys Gln Leu Lys Ser 
1               5                   10                  15      


Ile Met Gly Thr Asp Ser Leu Ser Asp Asp Val Val Leu Val Ile Ala 
            20                  25                  30          


Thr Thr Ser Leu Ala Leu Val Ala Gly Phe Val Val Leu Leu Trp Lys 
        35                  40                  45              


Lys Thr Thr Ala Asp Arg Ser Gly Glu Leu Lys Pro Leu Met Ile Pro 
    50                  55                  60                  


Lys Ser Leu Met Ala Lys Asp Glu Asp Asp Asp Leu Asp Leu Gly Ser 
65                  70                  75                  80  


Gly Lys Thr Arg Val Ser Ile Phe Phe Gly Thr Gln Thr Gly Thr Ala 
                85                  90                  95      


Glu Gly Phe Ala Lys Ala Leu Ser Glu Glu Ile Lys Ala Arg Tyr Glu 
            100                 105                 110         


Lys Ala Ala Val Lys Val Ile Asp Leu Asp Asp Tyr Ala Ala Asp Asp 
        115                 120                 125             


Asp Gln Tyr Glu Glu Lys Leu Lys Lys Glu Thr Leu Ala Phe Phe Cys 
    130                 135                 140                 


Val Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala Ala Arg Phe 
145                 150                 155                 160 


Tyr Lys Trp Phe Thr Glu Glu Asn Glu Arg Asp Ile Lys Leu Gln Gln 
                165                 170                 175     


Leu Ala Tyr Gly Val Phe Ala Leu Gly Asn Arg Gln Tyr Glu His Phe 
            180                 185                 190         


Asn Lys Ile Gly Ile Val Leu Asp Glu Glu Leu Cys Lys Lys Gly Ala 
        195                 200                 205             


Lys Arg Leu Ile Glu Val Gly Leu Gly Asp Asp Asp Gln Ser Ile Glu 
    210                 215                 220                 


Asp Asp Phe Asn Ala Trp Lys Glu Ser Leu Trp Ser Glu Leu Asp Lys 
225                 230                 235                 240 


Leu Leu Lys Asp Glu Asp Asp Lys Ser Val Ala Thr Pro Tyr Thr Ala 
                245                 250                 255     


Val Ile Pro Glu Tyr Arg Val Val Thr His Asp Pro Arg Phe Thr Thr 
            260                 265                 270         


Gln Lys Ser Met Glu Ser Asn Val Ala Asn Gly Asn Thr Thr Ile Asp 
        275                 280                 285             


Ile His His Pro Cys Arg Val Asp Val Ala Val Gln Lys Glu Leu His 
    290                 295                 300                 


Thr His Glu Ser Asp Arg Ser Cys Ile His Leu Glu Phe Asp Ile Ser 
305                 310                 315                 320 


Arg Thr Gly Ile Thr Tyr Glu Thr Gly Asp His Val Gly Val Tyr Ala 
                325                 330                 335     


Glu Asn His Val Glu Ile Val Glu Glu Ala Gly Lys Leu Leu Gly His 
            340                 345                 350         


Ser Leu Asp Leu Val Phe Ser Ile His Ala Asp Lys Glu Asp Gly Ser 
        355                 360                 365             


Pro Leu Glu Ser Ala Val Pro Pro Pro Phe Pro Gly Pro Cys Thr Leu 
    370                 375                 380                 


Gly Thr Gly Leu Ala Arg Tyr Ala Asp Leu Leu Asn Pro Pro Arg Lys 
385                 390                 395                 400 


Ser Ala Leu Val Ala Leu Ala Ala Tyr Ala Thr Glu Pro Ser Glu Ala 
                405                 410                 415     


Glu Lys Leu Lys His Leu Thr Ser Pro Asp Gly Lys Asp Glu Tyr Ser 
            420                 425                 430         


Gln Trp Ile Val Ala Ser Gln Arg Ser Leu Leu Glu Val Met Ala Ala 
        435                 440                 445             


Phe Pro Ser Ala Lys Pro Pro Leu Gly Val Phe Phe Ala Ala Ile Ala 
    450                 455                 460                 


Pro Arg Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Leu 
465                 470                 475                 480 


Ala Pro Ser Arg Val His Val Thr Ser Ala Leu Val Tyr Gly Pro Thr 
                485                 490                 495     


Pro Thr Gly Arg Ile His Lys Gly Val Cys Ser Thr Trp Met Lys Asn 
            500                 505                 510         


Ala Val Pro Ala Glu Lys Ser His Glu Cys Ser Gly Ala Pro Ile Phe 
        515                 520                 525             


Ile Arg Ala Ser Asn Phe Lys Leu Pro Ser Asn Pro Ser Thr Pro Ile 
    530                 535                 540                 


Val Met Val Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe Leu 
545                 550                 555                 560 


Gln Glu Arg Met Ala Leu Lys Glu Asp Gly Glu Glu Leu Gly Ser Ser 
                565                 570                 575     


Leu Leu Phe Phe Gly Cys Arg Asn Arg Gln Met Asp Phe Ile Tyr Glu 
            580                 585                 590         


Asp Glu Leu Asn Asn Phe Val Asp Gln Gly Val Ile Ser Glu Leu Ile 
        595                 600                 605             


Met Ala Phe Ser Arg Glu Gly Ala Gln Lys Glu Tyr Val Gln His Lys 
    610                 615                 620                 


Met Met Glu Lys Ala Ala Gln Val Trp Asp Leu Ile Lys Glu Glu Gly 
625                 630                 635                 640 


Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Arg Asp Val His 
                645                 650                 655     


Arg Thr Leu His Thr Ile Val Gln Glu Gln Glu Gly Val Ser Ser Ser 
            660                 665                 670         


Glu Ala Glu Ala Ile Val Lys Lys Leu Gln Thr Glu Gly Arg Tyr Leu 
        675                 680                 685             


Arg Asp Val Trp 
    690         


<210>  22
<211>  713
<212>  PRT
<213>  Fusarium fujikuroi

<400>  22

Met Ala Glu Leu Asp Thr Leu Asp Ile Val Val Leu Gly Val Ile Phe 
1               5                   10                  15      


Leu Gly Thr Val Ala Tyr Phe Thr Lys Gly Lys Leu Trp Gly Val Thr 
            20                  25                  30          


Lys Asp Pro Tyr Ala Asn Gly Phe Ala Ala Gly Gly Ala Ser Lys Pro 
        35                  40                  45              


Gly Arg Thr Arg Asn Ile Val Glu Ala Met Glu Glu Ser Gly Lys Asn 
    50                  55                  60                  


Cys Val Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Asp Tyr Ala 
65                  70                  75                  80  


Ser Arg Leu Ala Lys Glu Gly Lys Ser Arg Phe Gly Leu Asn Thr Met 
                85                  90                  95      


Ile Ala Asp Leu Glu Asp Tyr Asp Phe Asp Asn Leu Asp Thr Val Pro 
            100                 105                 110         


Ser Asp Asn Ile Val Met Phe Val Leu Ala Thr Tyr Gly Glu Gly Glu 
        115                 120                 125             


Pro Thr Asp Asn Ala Val Asp Phe Tyr Glu Phe Ile Thr Gly Glu Asp 
    130                 135                 140                 


Ala Ser Phe Asn Glu Gly Asn Asp Pro Pro Leu Gly Asn Leu Asn Tyr 
145                 150                 155                 160 


Val Ala Phe Gly Leu Gly Asn Asn Thr Tyr Glu His Tyr Asn Ser Met 
                165                 170                 175     


Val Arg Asn Val Asn Lys Ala Leu Glu Lys Leu Gly Ala His Arg Ile 
            180                 185                 190         


Gly Glu Ala Gly Glu Gly Asp Asp Gly Ala Gly Thr Met Glu Glu Asp 
        195                 200                 205             


Phe Leu Ala Trp Lys Asp Pro Met Trp Glu Ala Leu Ala Lys Lys Met 
    210                 215                 220                 


Gly Leu Glu Glu Arg Glu Ala Val Tyr Glu Pro Ile Phe Ala Ile Asn 
225                 230                 235                 240 


Glu Arg Asp Asp Leu Thr Pro Glu Ala Asn Glu Val Tyr Leu Gly Glu 
                245                 250                 255     


Pro Asn Lys Leu His Leu Glu Gly Thr Ala Lys Gly Pro Phe Asn Ser 
            260                 265                 270         


His Asn Pro Tyr Ile Ala Pro Ile Ala Glu Ser Tyr Glu Leu Phe Ser 
        275                 280                 285             


Ala Lys Asp Arg Asn Cys Leu His Met Glu Ile Asp Ile Ser Gly Ser 
    290                 295                 300                 


Asn Leu Lys Tyr Glu Thr Gly Asp His Ile Ala Ile Trp Pro Thr Asn 
305                 310                 315                 320 


Pro Gly Glu Glu Val Asn Lys Phe Leu Asp Ile Leu Asp Leu Ser Gly 
                325                 330                 335     


Lys Gln His Ser Val Val Thr Val Lys Ala Leu Glu Pro Thr Ala Lys 
            340                 345                 350         


Val Pro Phe Pro Asn Pro Thr Thr Tyr Asp Ala Ile Leu Arg Tyr His 
        355                 360                 365             


Leu Glu Ile Cys Ala Pro Val Ser Arg Gln Phe Val Ser Thr Leu Ala 
    370                 375                 380                 


Ala Phe Ala Pro Asn Asp Asp Ile Lys Ala Glu Met Asn Arg Leu Gly 
385                 390                 395                 400 


Ser Asp Lys Asp Tyr Phe His Glu Lys Thr Gly Pro His Tyr Tyr Asn 
                405                 410                 415     


Ile Ala Arg Phe Leu Ala Ser Val Ser Lys Gly Glu Lys Trp Thr Lys 
            420                 425                 430         


Ile Pro Phe Ser Ala Phe Ile Glu Gly Leu Thr Lys Leu Gln Pro Arg 
        435                 440                 445             


Tyr Tyr Ser Ile Ser Ser Ser Ser Leu Val Gln Pro Lys Lys Ile Ser 
    450                 455                 460                 


Ile Thr Ala Val Val Glu Ser Gln Gln Ile Pro Gly Arg Asp Asp Pro 
465                 470                 475                 480 


Phe Arg Gly Val Ala Thr Asn Tyr Leu Phe Ala Leu Lys Gln Lys Gln 
                485                 490                 495     


Asn Gly Asp Pro Asn Pro Ala Pro Phe Gly Gln Ser Tyr Glu Leu Thr 
            500                 505                 510         


Gly Pro Arg Asn Lys Tyr Asp Gly Ile His Val Pro Val His Val Arg 
        515                 520                 525             


His Ser Asn Phe Lys Leu Pro Ser Asp Pro Gly Lys Pro Ile Ile Met 
    530                 535                 540                 


Ile Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly Phe Val Gln Glu 
545                 550                 555                 560 


Arg Ala Lys Gln Ala Arg Asp Gly Val Glu Val Gly Lys Thr Leu Leu 
                565                 570                 575     


Phe Phe Gly Cys Arg Lys Ser Thr Glu Asp Phe Met Tyr Gln Lys Glu 
            580                 585                 590         


Trp Gln Glu Tyr Lys Glu Ala Leu Gly Asp Lys Phe Glu Met Ile Thr 
        595                 600                 605             


Ala Phe Ser Arg Glu Gly Ser Lys Lys Val Tyr Val Gln His Arg Leu 
    610                 615                 620                 


Lys Glu Arg Ser Lys Glu Val Ser Asp Leu Leu Ser Gln Lys Ala Tyr 
625                 630                 635                 640 


Phe Tyr Val Cys Gly Asp Ala Ala His Met Ala Arg Glu Val Asn Thr 
                645                 650                 655     


Val Leu Ala Gln Ile Ile Ala Glu Gly Arg Gly Val Ser Glu Ala Lys 
            660                 665                 670         


Gly Glu Glu Ile Val Lys Asn Met Arg Ser Ala Asn Gln Tyr Gln Val 
        675                 680                 685             


Cys Ser Asp Phe Val Thr Leu His Cys Lys Glu Thr Thr Tyr Ala Asn 
    690                 695                 700                 


Ser Glu Leu Gln Glu Asp Val Trp Ser 
705                 710             


<210>  23
<211>  2130
<212>  DNA
<213>  Stevia rebaudiana

<400>  23
atgcaatcgg aatccgttga agcatcgacg attgatttga tgactgctgt tttgaaggac       60

acagtgatcg atacagcgaa cgcatctgat aacggagact caaagatgcc gccggcgttg      120

gcgatgatgt tcgaaattcg tgatctgttg ctgattttga ctacgtcagt tgctgttttg      180

gtcggatgtt tcgttgtttt ggtgtggaag agatcgtccg ggaagaagtc cggcaaggaa      240

ttggagccgc cgaagatcgt tgtgccgaag aggcggctgg agcaggaggt tgatgatggt      300

aagaagaagg ttacgatttt cttcggaaca caaactggaa cggctgaagg tttcgctaag      360

gcacttttcg aagaagcgaa agcgcgatat gaaaaggcag cgtttaaagt gattgatttg      420

gatgattatg ctgctgattt ggatgagtat gcagagaagc tgaagaagga aacatatgct      480

ttcttcttct tggctacata tggagatggt gagccaactg ataatgctgc caaattttat      540

aaatggttta ctgagggaga cgagaaaggc gtttggcttc aaaaacttca atatggagta      600

tttggtcttg gcaacagaca atatgaacat ttcaacaaga ttggaatagt ggttgatgat      660

ggtctcaccg agcagggtgc aaaacgcatt gttcccgttg gtcttggaga cgacgatcaa      720

tcaattgaag acgatttttc ggcatggaaa gagttagtgt ggcccgaatt ggatctattg      780

cttcgcgatg aagatgacaa agctgctgca actccttaca cagctgcaat ccctgaatac      840

cgcgtcgtat ttcatgacaa acccgatgcg ttttctgatg atcatactca aaccaatggt      900

catgctgttc atgatgctca acatccatgc agatccaatg tggctgttaa aaaagagctt      960

catactcctg aatccgatcg ttcatgcaca catcttgaat ttgacatttc tcacactgga     1020

ttatcttatg aaactgggga tcatgttggt gtatactgtg aaaacctaat tgaagtagtg     1080

gaagaagctg ggaaattgtt aggattatca acagatactt atttctcgtt acatattgat     1140

aacgaagatg gttcaccact tggtggacct tcattacaac ctccttttcc tccttgtact     1200

ttaagaaaag cattgactaa ttatgcagat ctgttaagct ctcccaaaaa gtcaactttg     1260

cttgctctag ctgctcatgc ttccgatccc actgaagctg atcgtttaag atttcttgca     1320

tctcgcgagg gcaaggatga atatgctgaa tgggttgttg caaaccaaag aagtcttctt     1380

gaagtcatgg aagctttccc gtcagctaga ccgccacttg gtgttttctt tgcagcggtt     1440

gcaccgcgtt tacagcctcg ttactactct atttcttcct ccccaaagat ggaaccaaac     1500

aggattcatg ttacttgcgc gttggtttat gaaaaaactc ccgcaggtcg tatccacaaa     1560

ggaatctgct caacctggat gaagaacgct gtacctttga ccgaaagtca agattgcagt     1620

tgggcaccga tttttgttag aacatcaaac ttcagacttc caattgaccc gaaagtcccg     1680

gttatcatga ttggtcctgg aaccgggttg gctccattta ggggttttct tcaagaaaga     1740

ttggctctta aagaatccgg aaccgaactc gggtcatcta ttttattctt cggttgtaga     1800

aaccgcaaag tggattacat atatgagaat gaactcaaca actttgttga aaatggtgcg     1860

ctttctgagc ttgatgttgc tttctcccgc gatggcccga cgaaagaata cgtgcaacat     1920

aaaatgaccc aaaaggcttc tgaaatatgg aatatgcttt ctgagggagc atatttatat     1980

gtatgtggtg atgctaaagg catggctaaa gatgtacacc gtacacttca caccattgtg     2040

caagaacagg gaagtttgga ctcgtctaaa gcggagttgt atgtgaagaa tctacaaatg     2100

tcaggaagat acctccgtga tgtttggtaa                                      2130


<210>  24
<211>  2124
<212>  DNA
<213>  Stevia rebaudiana

<400>  24
atgcaatcta actccgtgaa gatttcgccg cttgatctgg taactgcgct gtttagcggc       60

aaggttttgg acacatcgaa cgcatcggaa tcgggagaat ctgctatgct gccgactata      120

gcgatgatta tggagaatcg tgagctgttg atgatactca caacgtcggt tgctgtattg      180

atcggatgcg ttgtcgtttt ggtgtggcgg agatcgtcta cgaagaagtc ggcgttggag      240

ccaccggtga ttgtggttcc gaagagagtg caagaggagg aagttgatga tggtaagaag      300

aaagttacgg ttttcttcgg cacccaaact ggaacagctg aaggcttcgc taaggcactt      360

gttgaggaag ctaaagctcg atatgaaaag gctgtcttta aagtaattga tttggatgat      420

tatgctgctg atgacgatga gtatgaggag aaactaaaga aagaatcttt ggcctttttc      480

tttttggcta cgtatggaga tggtgagcca acagataatg ctgccagatt ttataaatgg      540

tttactgagg gagatgcgaa aggagaatgg cttaataagc ttcaatatgg agtatttggt      600

ttgggtaaca gacaatatga acattttaac aagatcgcaa aagtggttga tgatggtctt      660

gtagaacagg gtgcaaagcg tcttgttcct gttggacttg gagatgatga tcaatgtatt      720

gaagatgact tcaccgcatg gaaagagtta gtatggccgg agttggatca attacttcgt      780

gatgaggatg acacaactgt tgctactcca tacacagctg ctgttgcaga atatcgcgtt      840

gtttttcatg aaaaaccaga cgcgctttct gaagattata gttatacaaa tggccatgct      900

gttcatgatg ctcaacatcc atgcagatcc aacgtggctg tcaaaaagga acttcatagt      960

cctgaatctg accggtcttg cactcatctt gaatttgaca tctcgaacac cggactatca     1020

tatgaaactg gggaccatgt tggagtttac tgtgaaaact tgagtgaagt tgtgaatgat     1080

gctgaaagat tagtaggatt accaccagac acttactcct ccatccacac tgatagtgaa     1140

gacgggtcgc cacttggcgg agcctcattg ccgcctcctt tcccgccatg cactttaagg     1200

aaagcattga cgtgttatgc tgatgttttg agttctccca agaagtcggc tttgcttgca     1260

ctagctgctc atgccaccga tcccagtgaa gctgatagat tgaaatttct tgcatccccc     1320

gccggaaagg atgaatattc tcaatggata gttgcaagcc aaagaagtct ccttgaagtc     1380

atggaagcat tcccgtcagc taagccttca cttggtgttt tctttgcatc tgttgccccg     1440

cgcttacaac caagatacta ctctatttct tcctcaccca agatggcacc ggataggatt     1500

catgttacat gtgcattagt ctatgagaaa acacctgcag gccgcatcca caaaggagtt     1560

tgttcaactt ggatgaagaa cgcagtgcct atgaccgaga gtcaagattg cagttgggcc     1620

ccaatatacg tccgaacatc caatttcaga ctaccatctg accctaaggt cccggttatc     1680

atgattggac ctggcactgg tttggctcct tttagaggtt tccttcaaga gcggttagct     1740

ttaaaggaag ccggaactga cctcggttta tccattttat tcttcggatg taggaatcgc     1800

aaagtggatt tcatatatga aaacgagctt aacaactttg tggagactgg tgctctttct     1860

gagcttattg ttgctttctc ccgtgaaggc ccgactaagg aatatgtgca acacaagatg     1920

agtgagaagg cttcggatat ctggaacttg ctttctgaag gagcatattt atacgtatgt     1980

ggtgatgcca aaggcatggc caaagatgta catcgaaccc tccacacaat tgtgcaagaa     2040

cagggatctc ttgactcgtc aaaggcagaa ctctacgtga agaatctaca aatgtcagga     2100

agatacctcc gtgacgtttg gtaa                                            2124


<210>  25
<211>  692
<212>  PRT
<213>  Arabidopsis thaliana

<400>  25

Met Thr Ser Ala Leu Tyr Ala Ser Asp Leu Phe Lys Gln Leu Lys Ser 
1               5                   10                  15      


Ile Met Gly Thr Asp Ser Leu Ser Asp Asp Val Val Leu Val Ile Ala 
            20                  25                  30          


Thr Thr Ser Leu Ala Leu Val Ala Gly Phe Val Val Leu Leu Trp Lys 
        35                  40                  45              


Lys Thr Thr Ala Asp Arg Ser Gly Glu Leu Lys Pro Leu Met Ile Pro 
    50                  55                  60                  


Lys Ser Leu Met Ala Lys Asp Glu Asp Asp Asp Leu Asp Leu Gly Ser 
65                  70                  75                  80  


Gly Lys Thr Arg Val Ser Ile Phe Phe Gly Thr Gln Thr Gly Thr Ala 
                85                  90                  95      


Glu Gly Phe Ala Lys Ala Leu Ser Glu Glu Ile Lys Ala Arg Tyr Glu 
            100                 105                 110         


Lys Ala Ala Val Lys Val Ile Asp Leu Asp Asp Tyr Ala Ala Asp Asp 
        115                 120                 125             


Asp Gln Tyr Glu Glu Lys Leu Lys Lys Glu Thr Leu Ala Phe Phe Cys 
    130                 135                 140                 


Val Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala Ala Arg Phe 
145                 150                 155                 160 


Tyr Lys Trp Phe Thr Glu Glu Asn Glu Arg Asp Ile Lys Leu Gln Gln 
                165                 170                 175     


Leu Ala Tyr Gly Val Phe Ala Leu Gly Asn Arg Gln Tyr Glu His Phe 
            180                 185                 190         


Asn Lys Ile Gly Ile Val Leu Asp Glu Glu Leu Cys Lys Lys Gly Ala 
        195                 200                 205             


Lys Arg Leu Ile Glu Val Gly Leu Gly Asp Asp Asp Gln Ser Ile Glu 
    210                 215                 220                 


Asp Asp Phe Asn Ala Trp Lys Glu Ser Leu Trp Ser Glu Leu Asp Lys 
225                 230                 235                 240 


Leu Leu Lys Asp Glu Asp Asp Lys Ser Val Ala Thr Pro Tyr Thr Ala 
                245                 250                 255     


Val Ile Pro Glu Tyr Arg Val Val Thr His Asp Pro Arg Phe Thr Thr 
            260                 265                 270         


Gln Lys Ser Met Glu Ser Asn Val Ala Asn Gly Asn Thr Thr Ile Asp 
        275                 280                 285             


Ile His His Pro Cys Arg Val Asp Val Ala Val Gln Lys Glu Leu His 
    290                 295                 300                 


Thr His Glu Ser Asp Arg Ser Cys Ile His Leu Glu Phe Asp Ile Ser 
305                 310                 315                 320 


Arg Thr Gly Ile Thr Tyr Glu Thr Gly Asp His Val Gly Val Tyr Ala 
                325                 330                 335     


Glu Asn His Val Glu Ile Val Glu Glu Ala Gly Lys Leu Leu Gly His 
            340                 345                 350         


Ser Leu Asp Leu Val Phe Ser Ile His Ala Asp Lys Glu Asp Gly Ser 
        355                 360                 365             


Pro Leu Glu Ser Ala Val Pro Pro Pro Phe Pro Gly Pro Cys Thr Leu 
    370                 375                 380                 


Gly Thr Gly Leu Ala Arg Tyr Ala Asp Leu Leu Asn Pro Pro Arg Lys 
385                 390                 395                 400 


Ser Ala Leu Val Ala Leu Ala Ala Tyr Ala Thr Glu Pro Ser Glu Ala 
                405                 410                 415     


Glu Lys Leu Lys His Leu Thr Ser Pro Asp Gly Lys Asp Glu Tyr Ser 
            420                 425                 430         


Gln Trp Ile Val Ala Ser Gln Arg Ser Leu Leu Glu Val Met Ala Ala 
        435                 440                 445             


Phe Pro Ser Ala Lys Pro Pro Leu Gly Val Phe Phe Ala Ala Ile Ala 
    450                 455                 460                 


Pro Arg Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Leu 
465                 470                 475                 480 


Ala Pro Ser Arg Val His Val Thr Ser Ala Leu Val Tyr Gly Pro Thr 
                485                 490                 495     


Pro Thr Gly Arg Ile His Lys Gly Val Cys Ser Thr Trp Met Lys Asn 
            500                 505                 510         


Ala Val Pro Ala Glu Lys Ser His Glu Cys Ser Gly Ala Pro Ile Phe 
        515                 520                 525             


Ile Arg Ala Ser Asn Phe Lys Leu Pro Ser Asn Pro Ser Thr Pro Ile 
    530                 535                 540                 


Val Met Val Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe Leu 
545                 550                 555                 560 


Gln Glu Arg Met Ala Leu Lys Glu Asp Gly Glu Glu Leu Gly Ser Ser 
                565                 570                 575     


Leu Leu Phe Phe Gly Cys Arg Asn Arg Gln Met Asp Phe Ile Tyr Glu 
            580                 585                 590         


Asp Glu Leu Asn Asn Phe Val Asp Gln Gly Val Ile Ser Glu Leu Ile 
        595                 600                 605             


Met Ala Phe Ser Arg Glu Gly Ala Gln Lys Glu Tyr Val Gln His Lys 
    610                 615                 620                 


Met Met Glu Lys Ala Ala Gln Val Trp Asp Leu Ile Lys Glu Glu Gly 
625                 630                 635                 640 


Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Arg Asp Val His 
                645                 650                 655     


Arg Thr Leu His Thr Ile Val Gln Glu Gln Glu Gly Val Ser Ser Ser 
            660                 665                 670         


Glu Ala Glu Ala Ile Val Lys Lys Leu Gln Thr Glu Gly Arg Tyr Leu 
        675                 680                 685             


Arg Asp Val Trp 
    690         


<210>  26
<211>  712
<212>  PRT
<213>  Arabidopsis thaliana

<400>  26

Met Ser Ser Ser Ser Ser Ser Ser Thr Ser Met Ile Asp Leu Met Ala 
1               5                   10                  15      


Ala Ile Ile Lys Gly Glu Pro Val Ile Val Ser Asp Pro Ala Asn Ala 
            20                  25                  30          


Ser Ala Tyr Glu Ser Val Ala Ala Glu Leu Ser Ser Met Leu Ile Glu 
        35                  40                  45              


Asn Arg Gln Phe Ala Met Ile Val Thr Thr Ser Ile Ala Val Leu Ile 
    50                  55                  60                  


Gly Cys Ile Val Met Leu Val Trp Arg Arg Ser Gly Ser Gly Asn Ser 
65                  70                  75                  80  


Lys Arg Val Glu Pro Leu Lys Pro Leu Val Ile Lys Pro Arg Glu Glu 
                85                  90                  95      


Glu Ile Asp Asp Gly Arg Lys Lys Val Thr Ile Phe Phe Gly Thr Gln 
            100                 105                 110         


Thr Gly Thr Ala Glu Gly Phe Ala Lys Ala Leu Gly Glu Glu Ala Lys 
        115                 120                 125             


Ala Arg Tyr Glu Lys Thr Arg Phe Lys Ile Val Asp Leu Asp Asp Tyr 
    130                 135                 140                 


Ala Ala Asp Asp Asp Glu Tyr Glu Glu Lys Leu Lys Lys Glu Asp Val 
145                 150                 155                 160 


Ala Phe Phe Phe Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn 
                165                 170                 175     


Ala Ala Arg Phe Tyr Lys Trp Phe Thr Glu Gly Asn Asp Arg Gly Glu 
            180                 185                 190         


Trp Leu Lys Asn Leu Lys Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln 
        195                 200                 205             


Tyr Glu His Phe Asn Lys Val Ala Lys Val Val Asp Asp Ile Leu Val 
    210                 215                 220                 


Glu Gln Gly Ala Gln Arg Leu Val Gln Val Gly Leu Gly Asp Asp Asp 
225                 230                 235                 240 


Gln Cys Ile Glu Asp Asp Phe Thr Ala Trp Arg Glu Ala Leu Trp Pro 
                245                 250                 255     


Glu Leu Asp Thr Ile Leu Arg Glu Glu Gly Asp Thr Ala Val Ala Thr 
            260                 265                 270         


Pro Tyr Thr Ala Ala Val Leu Glu Tyr Arg Val Ser Ile His Asp Ser 
        275                 280                 285             


Glu Asp Ala Lys Phe Asn Asp Ile Thr Leu Ala Asn Gly Asn Gly Tyr 
    290                 295                 300                 


Thr Val Phe Asp Ala Gln His Pro Tyr Lys Ala Asn Val Ala Val Lys 
305                 310                 315                 320 


Arg Glu Leu His Thr Pro Glu Ser Asp Arg Ser Cys Ile His Leu Glu 
                325                 330                 335     


Phe Asp Ile Ala Gly Ser Gly Leu Thr Met Lys Leu Gly Asp His Val 
            340                 345                 350         


Gly Val Leu Cys Asp Asn Leu Ser Glu Thr Val Asp Glu Ala Leu Arg 
        355                 360                 365             


Leu Leu Asp Met Ser Pro Asp Thr Tyr Phe Ser Leu His Ala Glu Lys 
    370                 375                 380                 


Glu Asp Gly Thr Pro Ile Ser Ser Ser Leu Pro Pro Pro Phe Pro Pro 
385                 390                 395                 400 


Cys Asn Leu Arg Thr Ala Leu Thr Arg Tyr Ala Cys Leu Leu Ser Ser 
                405                 410                 415     


Pro Lys Lys Ser Ala Leu Val Ala Leu Ala Ala His Ala Ser Asp Pro 
            420                 425                 430         


Thr Glu Ala Glu Arg Leu Lys His Leu Ala Ser Pro Ala Gly Lys Asp 
        435                 440                 445             


Glu Tyr Ser Lys Trp Val Val Glu Ser Gln Arg Ser Leu Leu Glu Val 
    450                 455                 460                 


Met Ala Glu Phe Pro Ser Ala Lys Pro Pro Leu Gly Val Phe Phe Ala 
465                 470                 475                 480 


Gly Val Ala Pro Arg Leu Gln Pro Arg Phe Tyr Ser Ile Ser Ser Ser 
                485                 490                 495     


Pro Lys Ile Ala Glu Thr Arg Ile His Val Thr Cys Ala Leu Val Tyr 
            500                 505                 510         


Glu Lys Met Pro Thr Gly Arg Ile His Lys Gly Val Cys Ser Thr Trp 
        515                 520                 525             


Met Lys Asn Ala Val Pro Tyr Glu Lys Ser Glu Lys Leu Phe Leu Gly 
    530                 535                 540                 


Arg Pro Ile Phe Val Arg Gln Ser Asn Phe Lys Leu Pro Ser Asp Ser 
545                 550                 555                 560 


Lys Val Pro Ile Ile Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe 
                565                 570                 575     


Arg Gly Phe Leu Gln Glu Arg Leu Ala Leu Val Glu Ser Gly Val Glu 
            580                 585                 590         


Leu Gly Pro Ser Val Leu Phe Phe Gly Cys Arg Asn Arg Arg Met Asp 
        595                 600                 605             


Phe Ile Tyr Glu Glu Glu Leu Gln Arg Phe Val Glu Ser Gly Ala Leu 
    610                 615                 620                 


Ala Glu Leu Ser Val Ala Phe Ser Arg Glu Gly Pro Thr Lys Glu Tyr 
625                 630                 635                 640 


Val Gln His Lys Met Met Asp Lys Ala Ser Asp Ile Trp Asn Met Ile 
                645                 650                 655     


Ser Gln Gly Ala Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala 
            660                 665                 670         


Arg Asp Val His Arg Ser Leu His Thr Ile Ala Gln Glu Gln Gly Ser 
        675                 680                 685             


Met Asp Ser Thr Lys Ala Glu Gly Phe Val Lys Asn Leu Gln Thr Ser 
    690                 695                 700                 


Gly Arg Tyr Leu Arg Asp Val Trp 
705                 710         


<210>  27
<211>  709
<212>  PRT
<213>  Stevia rebaudiana

<400>  27

Met Gln Ser Glu Ser Val Glu Ala Ser Thr Ile Asp Leu Met Thr Ala 
1               5                   10                  15      


Val Leu Lys Asp Thr Val Ile Asp Thr Ala Asn Ala Ser Asp Asn Gly 
            20                  25                  30          


Asp Ser Lys Met Pro Pro Ala Leu Ala Met Met Phe Glu Ile Arg Asp 
        35                  40                  45              


Leu Leu Leu Ile Leu Thr Thr Ser Val Ala Val Leu Val Gly Cys Phe 
    50                  55                  60                  


Val Val Leu Val Trp Lys Arg Ser Ser Gly Lys Lys Ser Gly Lys Glu 
65                  70                  75                  80  


Leu Glu Pro Pro Lys Ile Val Val Pro Lys Arg Arg Leu Glu Gln Glu 
                85                  90                  95      


Val Asp Asp Gly Lys Lys Lys Val Thr Ile Phe Phe Gly Thr Gln Thr 
            100                 105                 110         


Gly Thr Ala Glu Gly Phe Ala Lys Ala Leu Phe Glu Glu Ala Lys Ala 
        115                 120                 125             


Arg Tyr Glu Lys Ala Ala Phe Lys Val Ile Asp Leu Asp Asp Tyr Ala 
    130                 135                 140                 


Ala Asp Leu Asp Glu Tyr Ala Glu Lys Leu Lys Lys Glu Thr Tyr Ala 
145                 150                 155                 160 


Phe Phe Phe Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala 
                165                 170                 175     


Ala Lys Phe Tyr Lys Trp Phe Thr Glu Gly Asp Glu Lys Gly Val Trp 
            180                 185                 190         


Leu Gln Lys Leu Gln Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln Tyr 
        195                 200                 205             


Glu His Phe Asn Lys Ile Gly Ile Val Val Asp Asp Gly Leu Thr Glu 
    210                 215                 220                 


Gln Gly Ala Lys Arg Ile Val Pro Val Gly Leu Gly Asp Asp Asp Gln 
225                 230                 235                 240 


Ser Ile Glu Asp Asp Phe Ser Ala Trp Lys Glu Leu Val Trp Pro Glu 
                245                 250                 255     


Leu Asp Leu Leu Leu Arg Asp Glu Asp Asp Lys Ala Ala Ala Thr Pro 
            260                 265                 270         


Tyr Thr Ala Ala Ile Pro Glu Tyr Arg Val Val Phe His Asp Lys Pro 
        275                 280                 285             


Asp Ala Phe Ser Asp Asp His Thr Gln Thr Asn Gly His Ala Val His 
    290                 295                 300                 


Asp Ala Gln His Pro Cys Arg Ser Asn Val Ala Val Lys Lys Glu Leu 
305                 310                 315                 320 


His Thr Pro Glu Ser Asp Arg Ser Cys Thr His Leu Glu Phe Asp Ile 
                325                 330                 335     


Ser His Thr Gly Leu Ser Tyr Glu Thr Gly Asp His Val Gly Val Tyr 
            340                 345                 350         


Cys Glu Asn Leu Ile Glu Val Val Glu Glu Ala Gly Lys Leu Leu Gly 
        355                 360                 365             


Leu Ser Thr Asp Thr Tyr Phe Ser Leu His Ile Asp Asn Glu Asp Gly 
    370                 375                 380                 


Ser Pro Leu Gly Gly Pro Ser Leu Gln Pro Pro Phe Pro Pro Cys Thr 
385                 390                 395                 400 


Leu Arg Lys Ala Leu Thr Asn Tyr Ala Asp Leu Leu Ser Ser Pro Lys 
                405                 410                 415     


Lys Ser Thr Leu Leu Ala Leu Ala Ala His Ala Ser Asp Pro Thr Glu 
            420                 425                 430         


Ala Asp Arg Leu Arg Phe Leu Ala Ser Arg Glu Gly Lys Asp Glu Tyr 
        435                 440                 445             


Ala Glu Trp Val Val Ala Asn Gln Arg Ser Leu Leu Glu Val Met Glu 
    450                 455                 460                 


Ala Phe Pro Ser Ala Arg Pro Pro Leu Gly Val Phe Phe Ala Ala Val 
465                 470                 475                 480 


Ala Pro Arg Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Lys 
                485                 490                 495     


Met Glu Pro Asn Arg Ile His Val Thr Cys Ala Leu Val Tyr Glu Lys 
            500                 505                 510         


Thr Pro Ala Gly Arg Ile His Lys Gly Ile Cys Ser Thr Trp Met Lys 
        515                 520                 525             


Asn Ala Val Pro Leu Thr Glu Ser Gln Asp Cys Ser Trp Ala Pro Ile 
    530                 535                 540                 


Phe Val Arg Thr Ser Asn Phe Arg Leu Pro Ile Asp Pro Lys Val Pro 
545                 550                 555                 560 


Val Ile Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe 
                565                 570                 575     


Leu Gln Glu Arg Leu Ala Leu Lys Glu Ser Gly Thr Glu Leu Gly Ser 
            580                 585                 590         


Ser Ile Leu Phe Phe Gly Cys Arg Asn Arg Lys Val Asp Tyr Ile Tyr 
        595                 600                 605             


Glu Asn Glu Leu Asn Asn Phe Val Glu Asn Gly Ala Leu Ser Glu Leu 
    610                 615                 620                 


Asp Val Ala Phe Ser Arg Asp Gly Pro Thr Lys Glu Tyr Val Gln His 
625                 630                 635                 640 


Lys Met Thr Gln Lys Ala Ser Glu Ile Trp Asn Met Leu Ser Glu Gly 
                645                 650                 655     


Ala Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Lys Asp Val 
            660                 665                 670         


His Arg Thr Leu His Thr Ile Val Gln Glu Gln Gly Ser Leu Asp Ser 
        675                 680                 685             


Ser Lys Ala Glu Leu Tyr Val Lys Asn Leu Gln Met Ser Gly Arg Tyr 
    690                 695                 700                 


Leu Arg Asp Val Trp 
705                 


<210>  28
<211>  707
<212>  PRT
<213>  Stevia rebaudiana

<400>  28

Met Gln Ser Asn Ser Val Lys Ile Ser Pro Leu Asp Leu Val Thr Ala 
1               5                   10                  15      


Leu Phe Ser Gly Lys Val Leu Asp Thr Ser Asn Ala Ser Glu Ser Gly 
            20                  25                  30          


Glu Ser Ala Met Leu Pro Thr Ile Ala Met Ile Met Glu Asn Arg Glu 
        35                  40                  45              


Leu Leu Met Ile Leu Thr Thr Ser Val Ala Val Leu Ile Gly Cys Val 
    50                  55                  60                  


Val Val Leu Val Trp Arg Arg Ser Ser Thr Lys Lys Ser Ala Leu Glu 
65                  70                  75                  80  


Pro Pro Val Ile Val Val Pro Lys Arg Val Gln Glu Glu Glu Val Asp 
                85                  90                  95      


Asp Gly Lys Lys Lys Val Thr Val Phe Phe Gly Thr Gln Thr Gly Thr 
            100                 105                 110         


Ala Glu Gly Phe Ala Lys Ala Leu Val Glu Glu Ala Lys Ala Arg Tyr 
        115                 120                 125             


Glu Lys Ala Val Phe Lys Val Ile Asp Leu Asp Asp Tyr Ala Ala Asp 
    130                 135                 140                 


Asp Asp Glu Tyr Glu Glu Lys Leu Lys Lys Glu Ser Leu Ala Phe Phe 
145                 150                 155                 160 


Phe Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala Ala Arg 
                165                 170                 175     


Phe Tyr Lys Trp Phe Thr Glu Gly Asp Ala Lys Gly Glu Trp Leu Asn 
            180                 185                 190         


Lys Leu Gln Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln Tyr Glu His 
        195                 200                 205             


Phe Asn Lys Ile Ala Lys Val Val Asp Asp Gly Leu Val Glu Gln Gly 
    210                 215                 220                 


Ala Lys Arg Leu Val Pro Val Gly Leu Gly Asp Asp Asp Gln Cys Ile 
225                 230                 235                 240 


Glu Asp Asp Phe Thr Ala Trp Lys Glu Leu Val Trp Pro Glu Leu Asp 
                245                 250                 255     


Gln Leu Leu Arg Asp Glu Asp Asp Thr Thr Val Ala Thr Pro Tyr Thr 
            260                 265                 270         


Ala Ala Val Ala Glu Tyr Arg Val Val Phe His Glu Lys Pro Asp Ala 
        275                 280                 285             


Leu Ser Glu Asp Tyr Ser Tyr Thr Asn Gly His Ala Val His Asp Ala 
    290                 295                 300                 


Gln His Pro Cys Arg Ser Asn Val Ala Val Lys Lys Glu Leu His Ser 
305                 310                 315                 320 


Pro Glu Ser Asp Arg Ser Cys Thr His Leu Glu Phe Asp Ile Ser Asn 
                325                 330                 335     


Thr Gly Leu Ser Tyr Glu Thr Gly Asp His Val Gly Val Tyr Cys Glu 
            340                 345                 350         


Asn Leu Ser Glu Val Val Asn Asp Ala Glu Arg Leu Val Gly Leu Pro 
        355                 360                 365             


Pro Asp Thr Tyr Ser Ser Ile His Thr Asp Ser Glu Asp Gly Ser Pro 
    370                 375                 380                 


Leu Gly Gly Ala Ser Leu Pro Pro Pro Phe Pro Pro Cys Thr Leu Arg 
385                 390                 395                 400 


Lys Ala Leu Thr Cys Tyr Ala Asp Val Leu Ser Ser Pro Lys Lys Ser 
                405                 410                 415     


Ala Leu Leu Ala Leu Ala Ala His Ala Thr Asp Pro Ser Glu Ala Asp 
            420                 425                 430         


Arg Leu Lys Phe Leu Ala Ser Pro Ala Gly Lys Asp Glu Tyr Ser Gln 
        435                 440                 445             


Trp Ile Val Ala Ser Gln Arg Ser Leu Leu Glu Val Met Glu Ala Phe 
    450                 455                 460                 


Pro Ser Ala Lys Pro Ser Leu Gly Val Phe Phe Ala Ser Val Ala Pro 
465                 470                 475                 480 


Arg Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Lys Met Ala 
                485                 490                 495     


Pro Asp Arg Ile His Val Thr Cys Ala Leu Val Tyr Glu Lys Thr Pro 
            500                 505                 510         


Ala Gly Arg Ile His Lys Gly Val Cys Ser Thr Trp Met Lys Asn Ala 
        515                 520                 525             


Val Pro Met Thr Glu Ser Gln Asp Cys Ser Trp Ala Pro Ile Tyr Val 
    530                 535                 540                 


Arg Thr Ser Asn Phe Arg Leu Pro Ser Asp Pro Lys Val Pro Val Ile 
545                 550                 555                 560 


Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe Leu Gln 
                565                 570                 575     


Glu Arg Leu Ala Leu Lys Glu Ala Gly Thr Asp Leu Gly Leu Ser Ile 
            580                 585                 590         


Leu Phe Phe Gly Cys Arg Asn Arg Lys Val Asp Phe Ile Tyr Glu Asn 
        595                 600                 605             


Glu Leu Asn Asn Phe Val Glu Thr Gly Ala Leu Ser Glu Leu Ile Val 
    610                 615                 620                 


Ala Phe Ser Arg Glu Gly Pro Thr Lys Glu Tyr Val Gln His Lys Met 
625                 630                 635                 640 


Ser Glu Lys Ala Ser Asp Ile Trp Asn Leu Leu Ser Glu Gly Ala Tyr 
                645                 650                 655     


Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Lys Asp Val His Arg 
            660                 665                 670         


Thr Leu His Thr Ile Val Gln Glu Gln Gly Ser Leu Asp Ser Ser Lys 
        675                 680                 685             


Ala Glu Leu Tyr Val Lys Asn Leu Gln Met Ser Gly Arg Tyr Leu Arg 
    690                 695                 700                 


Asp Val Trp 
705         


<210>  29
<211>  460
<212>  PRT
<213>  Stevia rebaudiana

<400>  29

Met Ala Glu Gln Gln Lys Ile Lys Lys Ser Pro His Val Leu Leu Ile 
1               5                   10                  15      


Pro Phe Pro Leu Gln Gly His Ile Asn Pro Phe Ile Gln Phe Gly Lys 
            20                  25                  30          


Arg Leu Ile Ser Lys Gly Val Lys Thr Thr Leu Val Thr Thr Ile His 
        35                  40                  45              


Thr Leu Asn Ser Thr Leu Asn His Ser Asn Thr Thr Thr Thr Ser Ile 
    50                  55                  60                  


Glu Ile Gln Ala Ile Ser Asp Gly Cys Asp Glu Gly Gly Phe Met Ser 
65                  70                  75                  80  


Ala Gly Glu Ser Tyr Leu Glu Thr Phe Lys Gln Val Gly Ser Lys Ser 
                85                  90                  95      


Leu Ala Asp Leu Ile Lys Lys Leu Gln Ser Glu Gly Thr Thr Ile Asp 
            100                 105                 110         


Ala Ile Ile Tyr Asp Ser Met Thr Glu Trp Val Leu Asp Val Ala Ile 
        115                 120                 125             


Glu Phe Gly Ile Asp Gly Gly Ser Phe Phe Thr Gln Ala Cys Val Val 
    130                 135                 140                 


Asn Ser Leu Tyr Tyr His Val His Lys Gly Leu Ile Ser Leu Pro Leu 
145                 150                 155                 160 


Gly Glu Thr Val Ser Val Pro Gly Phe Pro Val Leu Gln Arg Trp Glu 
                165                 170                 175     


Thr Pro Leu Ile Leu Gln Asn His Glu Gln Ile Gln Ser Pro Trp Ser 
            180                 185                 190         


Gln Met Leu Phe Gly Gln Phe Ala Asn Ile Asp Gln Ala Arg Trp Val 
        195                 200                 205             


Phe Thr Asn Ser Phe Tyr Lys Leu Glu Glu Glu Val Ile Glu Trp Thr 
    210                 215                 220                 


Arg Lys Ile Trp Asn Leu Lys Val Ile Gly Pro Thr Leu Pro Ser Met 
225                 230                 235                 240 


Tyr Leu Asp Lys Arg Leu Asp Asp Asp Lys Asp Asn Gly Phe Asn Leu 
                245                 250                 255     


Tyr Lys Ala Asn His His Glu Cys Met Asn Trp Leu Asp Asp Lys Pro 
            260                 265                 270         


Lys Glu Ser Val Val Tyr Val Ala Phe Gly Ser Leu Val Lys His Gly 
        275                 280                 285             


Pro Glu Gln Val Glu Glu Ile Thr Arg Ala Leu Ile Asp Ser Asp Val 
    290                 295                 300                 


Asn Phe Leu Trp Val Ile Lys His Lys Glu Glu Gly Lys Leu Pro Glu 
305                 310                 315                 320 


Asn Leu Ser Glu Val Ile Lys Thr Gly Lys Gly Leu Ile Val Ala Trp 
                325                 330                 335     


Cys Lys Gln Leu Asp Val Leu Ala His Glu Ser Val Gly Cys Phe Val 
            340                 345                 350         


Thr His Cys Gly Phe Asn Ser Thr Leu Glu Ala Ile Ser Leu Gly Val 
        355                 360                 365             


Pro Val Val Ala Met Pro Gln Phe Ser Asp Gln Thr Thr Asn Ala Lys 
    370                 375                 380                 


Leu Leu Asp Glu Ile Leu Gly Val Gly Val Arg Val Lys Ala Asp Glu 
385                 390                 395                 400 


Asn Gly Ile Val Arg Arg Gly Asn Leu Ala Ser Cys Ile Lys Met Ile 
                405                 410                 415     


Met Glu Glu Glu Arg Gly Val Ile Ile Arg Lys Asn Ala Val Lys Trp 
            420                 425                 430         


Lys Asp Leu Ala Lys Val Ala Val His Glu Gly Gly Ser Ser Asp Asn 
        435                 440                 445             


Asp Ile Val Glu Phe Val Ser Glu Leu Ile Lys Ala 
    450                 455                 460 


<210>  30
<211>  481
<212>  PRT
<213>  Stevia rebaudiana

<400>  30

Met Asp Ala Met Ala Thr Thr Glu Lys Lys Pro His Val Ile Phe Ile 
1               5                   10                  15      


Pro Phe Pro Ala Gln Ser His Ile Lys Ala Met Leu Lys Leu Ala Gln 
            20                  25                  30          


Leu Leu His His Lys Gly Leu Gln Ile Thr Phe Val Asn Thr Asp Phe 
        35                  40                  45              


Ile His Asn Gln Phe Leu Glu Ser Ser Gly Pro His Cys Leu Asp Gly 
    50                  55                  60                  


Ala Pro Gly Phe Arg Phe Glu Thr Ile Pro Asp Gly Val Ser His Ser 
65                  70                  75                  80  


Pro Glu Ala Ser Ile Pro Ile Arg Glu Ser Leu Leu Arg Ser Ile Glu 
                85                  90                  95      


Thr Asn Phe Leu Asp Arg Phe Ile Asp Leu Val Thr Lys Leu Pro Asp 
            100                 105                 110         


Pro Pro Thr Cys Ile Ile Ser Asp Gly Phe Leu Ser Val Phe Thr Ile 
        115                 120                 125             


Asp Ala Ala Lys Lys Leu Gly Ile Pro Val Met Met Tyr Trp Thr Leu 
    130                 135                 140                 


Ala Ala Cys Gly Phe Met Gly Phe Tyr His Ile His Ser Leu Ile Glu 
145                 150                 155                 160 


Lys Gly Phe Ala Pro Leu Lys Asp Ala Ser Tyr Leu Thr Asn Gly Tyr 
                165                 170                 175     


Leu Asp Thr Val Ile Asp Trp Val Pro Gly Met Glu Gly Ile Arg Leu 
            180                 185                 190         


Lys Asp Phe Pro Leu Asp Trp Ser Thr Asp Leu Asn Asp Lys Val Leu 
        195                 200                 205             


Met Phe Thr Thr Glu Ala Pro Gln Arg Ser His Lys Val Ser His His 
    210                 215                 220                 


Ile Phe His Thr Phe Asp Glu Leu Glu Pro Ser Ile Ile Lys Thr Leu 
225                 230                 235                 240 


Ser Leu Arg Tyr Asn His Ile Tyr Thr Ile Gly Pro Leu Gln Leu Leu 
                245                 250                 255     


Leu Asp Gln Ile Pro Glu Glu Lys Lys Gln Thr Gly Ile Thr Ser Leu 
            260                 265                 270         


His Gly Tyr Ser Leu Val Lys Glu Glu Pro Glu Cys Phe Gln Trp Leu 
        275                 280                 285             


Gln Ser Lys Glu Pro Asn Ser Val Val Tyr Val Asn Phe Gly Ser Thr 
    290                 295                 300                 


Thr Val Met Ser Leu Glu Asp Met Thr Glu Phe Gly Trp Gly Leu Ala 
305                 310                 315                 320 


Asn Ser Asn His Tyr Phe Leu Trp Ile Ile Arg Ser Asn Leu Val Ile 
                325                 330                 335     


Gly Glu Asn Ala Val Leu Pro Pro Glu Leu Glu Glu His Ile Lys Lys 
            340                 345                 350         


Arg Gly Phe Ile Ala Ser Trp Cys Ser Gln Glu Lys Val Leu Lys His 
        355                 360                 365             


Pro Ser Val Gly Gly Phe Leu Thr His Cys Gly Trp Gly Ser Thr Ile 
    370                 375                 380                 


Glu Ser Leu Ser Ala Gly Val Pro Met Ile Cys Trp Pro Tyr Ser Trp 
385                 390                 395                 400 


Asp Gln Leu Thr Asn Cys Arg Tyr Ile Cys Lys Glu Trp Glu Val Gly 
                405                 410                 415     


Leu Glu Met Gly Thr Lys Val Lys Arg Asp Glu Val Lys Arg Leu Val 
            420                 425                 430         


Gln Glu Leu Met Gly Glu Gly Gly His Lys Met Arg Asn Lys Ala Lys 
        435                 440                 445             


Asp Trp Lys Glu Lys Ala Arg Ile Ala Ile Ala Pro Asn Gly Ser Ser 
    450                 455                 460                 


Ser Leu Asn Ile Asp Lys Met Val Lys Glu Ile Thr Val Leu Ala Arg 
465                 470                 475                 480 


Asn 
    


<210>  31
<211>  1586
<212>  DNA
<213>  Stevia rebaudiana

<400>  31
atggatgcaa tggctacaac tgagaagaaa ccacacgtca tcttcatacc atttccagca       60

caaagccaca ttaaagccat gctcaaacta gcacaacttc tccaccacaa aggactccag      120

ataaccttcg tcaacaccga cttcatccac aaccagtttc ttgaatcatc gggcccacat      180

tgtctagacg gtgcaccggg tttccggttc gaaaccattc cggatggtgt ttctcacagt      240

ccggaagcga gcatcccaat cagagaatca ctcttgagat ccattgaaac caacttcttg      300

gatcgtttca ttgatcttgt aaccaaactt ccggatcctc cgacttgtat tatctcagat      360

gggttcttgt cggttttcac aattgacgct gcaaaaaagc ttggaattcc ggtcatgatg      420

tattggacac ttgctgcctg tgggttcatg ggtttttacc atattcattc tctcattgag      480

aaaggatttg caccacttaa agatgcaagt tacttgacaa atgggtattt ggacaccgtc      540

attgattggg ttccgggaat ggaaggcatc cgtctcaagg atttcccgct ggactggagc      600

actgacctca atgacaaagt tttgatgttc actacggaag ctcctcaaag gtcacacaag      660

gtttcacatc atattttcca cacgttcgat gagttggagc ctagtattat aaaaactttg      720

tcattgaggt ataatcacat ttacaccatc ggcccactgc aattacttct tgatcaaata      780

cccgaagaga aaaagcaaac tggaattacg agtctccatg gatacagttt agtaaaagaa      840

gaaccagagt gtttccagtg gcttcagtct aaagaaccaa attccgtcgt ttatgtaaat      900

tttggaagta ctacagtaat gtctttagaa gacatgacgg aatttggttg gggacttgct      960

aatagcaacc attatttcct ttggatcatc cgatcaaact tggtgatagg ggaaaatgca     1020

gttttgcccc ctgaacttga ggaacatata aagaaaagag gctttattgc tagctggtgt     1080

tcacaagaaa aggtcttgaa gcacccttcg gttggagggt tcttgactca ttgtgggtgg     1140

ggatcgacca tcgagagctt gtctgctggg gtgccaatga tatgctggcc ttattcgtgg     1200

gaccagctga ccaactgtag gtatatatgc aaagaatggg aggttgggct cgagatggga     1260

accaaagtga aacgagatga agtcaagagg cttgtacaag agttgatggg agaaggaggt     1320

cacaaaatga ggaacaaggc taaagattgg aaagaaaagg ctcgcattgc aatagctcct     1380

aacggttcat cttctttgaa catagacaaa atggtcaagg aaatcaccgt gctagcaaga     1440

aactagttac aaagttgttt cacattgtgc tttctattta agatgtaact ttgttctaat     1500

ttaatattgt ctagatgtat tgaaccataa gtttagttgg tctcaggaat tgatttttaa     1560

tgaaataatg gtcattaggg gtgagt                                          1586


<210>  32
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleotide sequence encoding Stevia rebaudiana 
       UGT85C2

<400>  32
atggatgcaa tggcaactac tgagaaaaag cctcatgtga tcttcattcc atttcctgca       60

caatctcaca taaaggcaat gctaaagtta gcacaactat tacaccataa gggattacag      120

ataactttcg tgaataccga cttcatccat aatcaatttc tggaatctag tggccctcat      180

tgtttggacg gagccccagg gtttagattc gaaacaattc ctgacggtgt ttcacattcc      240

ccagaggcct ccatcccaat aagagagagt ttactgaggt caatagaaac caactttttg      300

gatcgtttca ttgacttggt cacaaaactt ccagacccac caacttgcat aatctctgat      360

ggctttctgt cagtgtttac tatcgacgct gccaaaaagt tgggtatccc agttatgatg      420

tactggactc ttgctgcatg cggtttcatg ggtttctatc acatccattc tcttatcgaa      480

aagggttttg ctccactgaa agatgcatca tacttaacca acggctacct ggatactgtt      540

attgactggg taccaggtat ggaaggtata agacttaaag attttccttt ggattggtct      600

acagacctta atgataaagt attgatgttt actacagaag ctccacaaag atctcataag      660

gtttcacatc atatctttca cacctttgat gaattggaac catcaatcat caaaaccttg      720

tctctaagat acaatcatat ctacactatt ggtccattac aattacttct agatcaaatt      780

cctgaagaga aaaagcaaac tggtattaca tccttacacg gctactcttt agtgaaagag      840

gaaccagaat gttttcaatg gctacaaagt aaagagccta attctgtggt ctacgtcaac      900

ttcggaagta caacagtcat gtccttggaa gatatgactg aatttggttg gggccttgct      960

aattcaaatc attactttct atggattatc aggtccaatt tggtaatagg ggaaaacgcc     1020

gtattacctc cagaattgga ggaacacatc aaaaagagag gtttcattgc ttcctggtgt     1080

tctcaggaaa aggtattgaa acatccttct gttggtggtt tccttactca ttgcggttgg     1140

ggctctacaa tcgaatcact aagtgcagga gttccaatga tttgttggcc atattcatgg     1200

gaccaactta caaattgtag gtatatctgt aaagagtggg aagttggatt agaaatggga     1260

acaaaggtta aacgtgatga agtgaaaaga ttggttcagg agttgatggg ggaaggtggc     1320

cacaagatga gaaacaaggc caaagattgg aaggaaaaag ccagaattgc tattgctcct     1380

aacgggtcat cctctctaaa cattgataag atggtcaaag agattacagt cttagccaga     1440

aactaa                                                                1446


<210>  33
<211>  787
<212>  PRT
<213>  Stevia rebaudiana

<400>  33

Met Lys Thr Gly Phe Ile Ser Pro Ala Thr Val Phe His His Arg Ile 
1               5                   10                  15      


Ser Pro Ala Thr Thr Phe Arg His His Leu Ser Pro Ala Thr Thr Asn 
            20                  25                  30          


Ser Thr Gly Ile Val Ala Leu Arg Asp Ile Asn Phe Arg Cys Lys Ala 
        35                  40                  45              


Val Ser Lys Glu Tyr Ser Asp Leu Leu Gln Lys Asp Glu Ala Ser Phe 
    50                  55                  60                  


Thr Lys Trp Asp Asp Asp Lys Val Lys Asp His Leu Asp Thr Asn Lys 
65                  70                  75                  80  


Asn Leu Tyr Pro Asn Asp Glu Ile Lys Glu Phe Val Glu Ser Val Lys 
                85                  90                  95      


Ala Met Phe Gly Ser Met Asn Asp Gly Glu Ile Asn Val Ser Ala Tyr 
            100                 105                 110         


Asp Thr Ala Trp Val Ala Leu Val Gln Asp Val Asp Gly Ser Gly Ser 
        115                 120                 125             


Pro Gln Phe Pro Ser Ser Leu Glu Trp Ile Ala Asn Asn Gln Leu Ser 
    130                 135                 140                 


Asp Gly Ser Trp Gly Asp His Leu Leu Phe Ser Ala His Asp Arg Ile 
145                 150                 155                 160 


Ile Asn Thr Leu Ala Cys Val Ile Ala Leu Thr Ser Trp Asn Val His 
                165                 170                 175     


Pro Ser Lys Cys Glu Lys Gly Leu Asn Phe Leu Arg Glu Asn Ile Cys 
            180                 185                 190         


Lys Leu Glu Asp Glu Asn Ala Glu His Met Pro Ile Gly Phe Glu Val 
        195                 200                 205             


Thr Phe Pro Ser Leu Ile Asp Ile Ala Lys Lys Leu Asn Ile Glu Val 
    210                 215                 220                 


Pro Glu Asp Thr Pro Ala Leu Lys Glu Ile Tyr Ala Arg Arg Asp Ile 
225                 230                 235                 240 


Lys Leu Thr Lys Ile Pro Met Glu Val Leu His Lys Val Pro Thr Thr 
                245                 250                 255     


Leu Leu His Ser Leu Glu Gly Met Pro Asp Leu Glu Trp Glu Lys Leu 
            260                 265                 270         


Leu Lys Leu Gln Cys Lys Asp Gly Ser Phe Leu Phe Ser Pro Ser Ser 
        275                 280                 285             


Thr Ala Phe Ala Leu Met Gln Thr Lys Asp Glu Lys Cys Leu Gln Tyr 
    290                 295                 300                 


Leu Thr Asn Ile Val Thr Lys Phe Asn Gly Gly Val Pro Asn Val Tyr 
305                 310                 315                 320 


Pro Val Asp Leu Phe Glu His Ile Trp Val Val Asp Arg Leu Gln Arg 
                325                 330                 335     


Leu Gly Ile Ala Arg Tyr Phe Lys Ser Glu Ile Lys Asp Cys Val Glu 
            340                 345                 350         


Tyr Ile Asn Lys Tyr Trp Thr Lys Asn Gly Ile Cys Trp Ala Arg Asn 
        355                 360                 365             


Thr His Val Gln Asp Ile Asp Asp Thr Ala Met Gly Phe Arg Val Leu 
    370                 375                 380                 


Arg Ala His Gly Tyr Asp Val Thr Pro Asp Val Phe Arg Gln Phe Glu 
385                 390                 395                 400 


Lys Asp Gly Lys Phe Val Cys Phe Ala Gly Gln Ser Thr Gln Ala Val 
                405                 410                 415     


Thr Gly Met Phe Asn Val Tyr Arg Ala Ser Gln Met Leu Phe Pro Gly 
            420                 425                 430         


Glu Arg Ile Leu Glu Asp Ala Lys Lys Phe Ser Tyr Asn Tyr Leu Lys 
        435                 440                 445             


Glu Lys Gln Ser Thr Asn Glu Leu Leu Asp Lys Trp Ile Ile Ala Lys 
    450                 455                 460                 


Asp Leu Pro Gly Glu Val Gly Tyr Ala Leu Asp Ile Pro Trp Tyr Ala 
465                 470                 475                 480 


Ser Leu Pro Arg Leu Glu Thr Arg Tyr Tyr Leu Glu Gln Tyr Gly Gly 
                485                 490                 495     


Glu Asp Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Gly Tyr Val 
            500                 505                 510         


Ser Asn Asn Thr Tyr Leu Glu Met Ala Lys Leu Asp Tyr Asn Asn Tyr 
        515                 520                 525             


Val Ala Val Leu Gln Leu Glu Trp Tyr Thr Ile Gln Gln Trp Tyr Val 
    530                 535                 540                 


Asp Ile Gly Ile Glu Lys Phe Glu Ser Asp Asn Ile Lys Ser Val Leu 
545                 550                 555                 560 


Val Ser Tyr Tyr Leu Ala Ala Ala Ser Ile Phe Glu Pro Glu Arg Ser 
                565                 570                 575     


Lys Glu Arg Ile Ala Trp Ala Lys Thr Thr Ile Leu Val Asp Lys Ile 
            580                 585                 590         


Thr Ser Ile Phe Asp Ser Ser Gln Ser Ser Lys Glu Asp Ile Thr Ala 
        595                 600                 605             


Phe Ile Asp Lys Phe Arg Asn Lys Ser Ser Ser Lys Lys His Ser Ile 
    610                 615                 620                 


Asn Gly Glu Pro Trp His Glu Val Met Val Ala Leu Lys Lys Thr Leu 
625                 630                 635                 640 


His Gly Phe Ala Leu Asp Ala Leu Met Thr His Ser Gln Asp Ile His 
                645                 650                 655     


Pro Gln Leu His Gln Ala Trp Glu Met Trp Leu Thr Lys Leu Gln Asp 
            660                 665                 670         


Gly Val Asp Val Thr Ala Glu Leu Met Val Gln Met Ile Asn Met Thr 
        675                 680                 685             


Ala Gly Arg Trp Val Ser Lys Glu Leu Leu Thr His Pro Gln Tyr Gln 
    690                 695                 700                 


Arg Leu Ser Thr Val Thr Asn Ser Val Cys His Asp Ile Thr Lys Leu 
705                 710                 715                 720 


His Asn Phe Lys Glu Asn Ser Thr Thr Val Asp Ser Lys Val Gln Glu 
                725                 730                 735     


Leu Val Gln Leu Val Phe Ser Asp Thr Pro Asp Asp Leu Asp Gln Asp 
            740                 745                 750         


Met Lys Gln Thr Phe Leu Thr Val Met Lys Thr Phe Tyr Tyr Lys Ala 
        755                 760                 765             


Trp Cys Asp Pro Asn Thr Ile Asn Asp His Ile Ser Lys Val Phe Glu 
    770                 775                 780                 


Ile Val Ile 
785         


<210>  34
<211>  527
<212>  PRT
<213>  Streptomyces clavuligerus

<400>  34

Met Pro Asp Ala His Asp Ala Pro Pro Pro Gln Ile Arg Gln Arg Thr 
1               5                   10                  15      


Leu Val Asp Glu Ala Thr Gln Leu Leu Thr Glu Ser Ala Glu Asp Ala 
            20                  25                  30          


Trp Gly Glu Val Ser Val Ser Glu Tyr Glu Thr Ala Arg Leu Val Ala 
        35                  40                  45              


His Ala Thr Trp Leu Gly Gly His Ala Thr Arg Val Ala Phe Leu Leu 
    50                  55                  60                  


Glu Arg Gln His Glu Asp Gly Ser Trp Gly Pro Pro Gly Gly Tyr Arg 
65                  70                  75                  80  


Leu Val Pro Thr Leu Ser Ala Val His Ala Leu Leu Thr Cys Leu Ala 
                85                  90                  95      


Ser Pro Ala Gln Asp His Gly Val Pro His Asp Arg Leu Leu Arg Ala 
            100                 105                 110         


Val Asp Ala Gly Leu Thr Ala Leu Arg Arg Leu Gly Thr Ser Asp Ser 
        115                 120                 125             


Pro Pro Asp Thr Ile Ala Val Glu Leu Val Ile Pro Ser Leu Leu Glu 
    130                 135                 140                 


Gly Ile Gln His Leu Leu Asp Pro Ala His Pro His Ser Arg Pro Ala 
145                 150                 155                 160 


Phe Ser Gln His Arg Gly Ser Leu Val Cys Pro Gly Gly Leu Asp Gly 
                165                 170                 175     


Arg Thr Leu Gly Ala Leu Arg Ser His Ala Ala Ala Gly Thr Pro Val 
            180                 185                 190         


Pro Gly Lys Val Trp His Ala Ser Glu Thr Leu Gly Leu Ser Thr Glu 
        195                 200                 205             


Ala Ala Ser His Leu Gln Pro Ala Gln Gly Ile Ile Gly Gly Ser Ala 
    210                 215                 220                 


Ala Ala Thr Ala Thr Trp Leu Thr Arg Val Ala Pro Ser Gln Gln Ser 
225                 230                 235                 240 


Asp Ser Ala Arg Arg Tyr Leu Glu Glu Leu Gln His Arg Tyr Ser Gly 
                245                 250                 255     


Pro Val Pro Ser Ile Thr Pro Ile Thr Tyr Phe Glu Arg Ala Trp Leu 
            260                 265                 270         


Leu Asn Asn Phe Ala Ala Ala Gly Val Pro Cys Glu Ala Pro Ala Ala 
        275                 280                 285             


Leu Leu Asp Ser Leu Glu Ala Ala Leu Thr Pro Gln Gly Ala Pro Ala 
    290                 295                 300                 


Gly Ala Gly Leu Pro Pro Asp Ala Asp Asp Thr Ala Ala Val Leu Leu 
305                 310                 315                 320 


Ala Leu Ala Thr His Gly Arg Gly Arg Arg Pro Glu Val Leu Met Asp 
                325                 330                 335     


Tyr Arg Thr Asp Gly Tyr Phe Gln Cys Phe Ile Gly Glu Arg Thr Pro 
            340                 345                 350         


Ser Ile Ser Thr Asn Ala His Val Leu Glu Thr Leu Gly His His Val 
        355                 360                 365             


Ala Gln His Pro Gln Asp Arg Ala Arg Tyr Gly Ser Ala Met Asp Thr 
    370                 375                 380                 


Ala Ser Ala Trp Leu Leu Ala Ala Gln Lys Gln Asp Gly Ser Trp Leu 
385                 390                 395                 400 


Asp Lys Trp His Ala Ser Pro Tyr Tyr Ala Thr Val Cys Cys Thr Gln 
                405                 410                 415     


Ala Leu Ala Ala His Ala Ser Pro Ala Thr Ala Pro Ala Arg Gln Arg 
            420                 425                 430         


Ala Val Arg Trp Val Leu Ala Thr Gln Arg Ser Asp Gly Gly Trp Gly 
        435                 440                 445             


Leu Trp His Ser Thr Val Glu Glu Thr Ala Tyr Ala Leu Gln Ile Leu 
    450                 455                 460                 


Ala Pro Pro Ser Gly Gly Gly Asn Ile Pro Val Gln Gln Ala Leu Thr 
465                 470                 475                 480 


Arg Gly Arg Ala Arg Leu Cys Gly Ala Leu Pro Leu Thr Pro Leu Trp 
                485                 490                 495     


His Asp Lys Asp Leu Tyr Thr Pro Val Arg Val Val Arg Ala Ala Arg 
            500                 505                 510         


Ala Ala Ala Leu Tyr Thr Thr Arg Asp Leu Leu Leu Pro Pro Leu 
        515                 520                 525         


<210>  35
<211>  516
<212>  PRT
<213>  Bradyrhizobium diazoefficiens

<400>  35

Met Asn Ala Leu Ser Glu His Ile Leu Ser Glu Leu Arg Arg Leu Leu 
1               5                   10                  15      


Ser Glu Met Ser Asp Gly Gly Ser Val Gly Pro Ser Val Tyr Asp Thr 
            20                  25                  30          


Ala Gln Ala Leu Arg Phe His Gly Asn Val Thr Gly Arg Gln Asp Ala 
        35                  40                  45              


Tyr Ala Trp Leu Ile Ala Gln Gln Gln Ala Asp Gly Gly Trp Gly Ser 
    50                  55                  60                  


Ala Asp Phe Pro Leu Phe Arg His Ala Pro Thr Trp Ala Ala Leu Leu 
65                  70                  75                  80  


Ala Leu Gln Arg Ala Asp Pro Leu Pro Gly Ala Ala Asp Ala Val Gln 
                85                  90                  95      


Thr Ala Thr Arg Phe Leu Gln Arg Gln Pro Asp Pro Tyr Ala His Ala 
            100                 105                 110         


Val Pro Glu Asp Ala Pro Ile Gly Ala Glu Leu Ile Leu Pro Gln Phe 
        115                 120                 125             


Cys Gly Glu Ala Ala Trp Leu Leu Gly Gly Val Ala Phe Pro Arg His 
    130                 135                 140                 


Pro Ala Leu Leu Pro Leu Arg Gln Ala Cys Leu Val Lys Leu Gly Ala 
145                 150                 155                 160 


Val Ala Met Leu Pro Ser Gly His Pro Leu Leu His Ser Trp Glu Ala 
                165                 170                 175     


Trp Gly Thr Ser Pro Thr Thr Ala Cys Pro Asp Asp Asp Gly Ser Ile 
            180                 185                 190         


Gly Ile Ser Pro Ala Ala Thr Ala Ala Trp Arg Ala Gln Ala Val Thr 
        195                 200                 205             


Arg Gly Ser Thr Pro Gln Val Gly Arg Ala Asp Ala Tyr Leu Gln Met 
    210                 215                 220                 


Ala Ser Arg Ala Thr Arg Ser Gly Ile Glu Gly Val Phe Pro Asn Val 
225                 230                 235                 240 


Trp Pro Ile Asn Val Phe Glu Pro Cys Trp Ser Leu Tyr Thr Leu His 
                245                 250                 255     


Leu Ala Gly Leu Phe Ala His Pro Ala Leu Ala Glu Ala Val Arg Val 
            260                 265                 270         


Ile Val Ala Gln Leu Glu Ala Arg Leu Gly Val His Gly Leu Gly Pro 
        275                 280                 285             


Ala Leu His Phe Ala Ala Asp Ala Asp Asp Thr Ala Val Ala Leu Cys 
    290                 295                 300                 


Val Leu His Leu Ala Gly Arg Asp Pro Ala Val Asp Ala Leu Arg His 
305                 310                 315                 320 


Phe Glu Ile Gly Glu Leu Phe Val Thr Phe Pro Gly Glu Arg Asn Ala 
                325                 330                 335     


Ser Val Ser Thr Asn Ile His Ala Leu His Ala Leu Arg Leu Leu Gly 
            340                 345                 350         


Lys Pro Ala Ala Gly Ala Ser Ala Tyr Val Glu Ala Asn Arg Asn Pro 
        355                 360                 365             


His Gly Leu Trp Asp Asn Glu Lys Trp His Val Ser Trp Leu Tyr Pro 
    370                 375                 380                 


Thr Ala His Ala Val Ala Ala Leu Ala Gln Gly Lys Pro Gln Trp Arg 
385                 390                 395                 400 


Asp Glu Arg Ala Leu Ala Ala Leu Leu Gln Ala Gln Arg Asp Asp Gly 
                405                 410                 415     


Gly Trp Gly Ala Gly Arg Gly Ser Thr Phe Glu Glu Thr Ala Tyr Ala 
            420                 425                 430         


Leu Phe Ala Leu His Val Met Asp Gly Ser Glu Glu Ala Thr Gly Arg 
        435                 440                 445             


Arg Arg Ile Ala Gln Val Val Ala Arg Ala Leu Glu Trp Met Leu Ala 
    450                 455                 460                 


Arg His Ala Ala His Gly Leu Pro Gln Thr Pro Leu Trp Ile Gly Lys 
465                 470                 475                 480 


Glu Leu Tyr Cys Pro Thr Arg Val Val Arg Val Ala Glu Leu Ala Gly 
                485                 490                 495     


Leu Trp Leu Ala Leu Arg Trp Gly Arg Arg Val Leu Ala Glu Gly Ala 
            500                 505                 510         


Gly Ala Ala Pro 
        515     


<210>  36
<211>  4577
<212>  DNA
<213>  Zea mays

<400>  36
gacctgacca ccaccccccg gccggccctt tcattctttc cttactttct tcctcctgct       60

gctcttgccg tttcagtgat tattagctgc tgtacgtgcg tgcgtacatt gttctctctg      120

ctgacaccca tacacgctgt agcttctaca cataccagtt cgatcgcaag ctatagcatg      180

gggcttcaat catcgcccat gctgctgcca gcgccgacgg caacggcggc cggcagcggg      240

tcacagtggc gcacggctgt ggcgggtaat ggtaactcgt ttatcttctt ctacacgtaa      300

tctctattat atacctagat tttctccaca ggcagatcag attctttaca cagctgtatt      360

ctcaaaaaaa actcatagaa aaaaaagaaa aaactaaacc aaaggagcga cctcaacctg      420

taccagtgcc cctgctagca gtagcttcgt tctgtccctt ttttttcatt tggatcctct      480

acataaatgc tgggtggtgg tgtcctttca cgcacacatc cgcagatagc gccccagcag      540

catttatgtg gggacgacgg ctctgaaatg aattactagt cagtttcatg cgtttcagtg      600

cgagtattat agtagtagat ctcttctccg atatatccgg ccaaaggaag aagagaagag      660

aaaccacaca tctcattctc aactagtagt agaaaagtaa aaacgtacta caagcgcaag      720

cgcaaagatg gttctttcat cgtcttgcac aacagttcct cacctttctt cccttgcggt      780

cgttcaacta ggcccatgga gttcccgcat caagaagaag acggatacag tcgccgtccc      840

cgcggccgcc ggccggtgga ggagggcact ggcgcgggcc cagcacacca gcgaatccgc      900

cgccgtcgcc aaaggtacgg gtgatcgcta gctttgatag ctccaaatct gagcagcaaa      960

ttaaatagct aggtttgtaa cgcacgcacg catgcaggtt cgtccctaac gcccatcgtg     1020

agaaccgatg ccgaaagccg ccgcacgaga tggcctacgg acgacgacga cgctgagccg     1080

ctggtcgacg agatcagggc aatgctgacg tcgatgagcg acggggacat cagcgtgtcg     1140

gcgtacgaca ccgcctgggt gggtcttgtg cccaggctgg acggcggcga gggcccgcag     1200

ttcccggccg ccgtgcggtg gatccggaac aaccagctcc ccgacggctc gtggggcgac     1260

gcggccctgt tctccgcgta cgaccgcctg atcaacacgc tggcgtgcgt cgtcacgctc     1320

accaggtggt cgctggagcc cgagatgcgc ggcagaggta cgtaattact gtgtgctggc     1380

cgatcgagag aacacacgac ggcagtgtac ctcgacagaa aacgggcgtt gctgaagact     1440

caagtgtgtg tgtgtgtgtg ttcacagggc tctctttcct cggccggaac atgtggaagc     1500

tagcgacgga ggacgaggag tccatgccga tagggttcga gctcgcgttc ccttctctca     1560

tcgaactagc caagagtctg ggcgtccacg acttcccgta cgaccaccag gctctgcagg     1620

gaatatactc gagcagggag atcaagatga agaggattcc taaggaagtg atgcacacgg     1680

ttcccacatc cattctccac agcctggaag ggatgcccgg gctagactgg gcgaagctgc     1740

tgaaactgca gtcgagcgac gggtccttcc tcttctctcc cgcggccacc gcgtacgctc     1800

tcatgaacac cggcgacgac aggtgcttca gctacatcga caggacagtc aagaaattca     1860

acggaggagg tacgcaagca gtagcgtaga tacatgggca tagcatgcat gcatgcaatg     1920

cagcgttgcc cactgcatgc gccttccttc cttccttctc gtctcttcaa cggttcgtct     1980

tctctcgccg tttctcgcag tgcccaacgt ctaccccgtg gaccttttcg agcacatatg     2040

ggctgtcgat cgcctggagc gtctcgggat ctcccgctac ttccagaaag agattgagca     2100

gtgcatggac tacgtgaaca ggcactggac tgaggacggg atctgctggg cgaggaactc     2160

cgacgtgaag gaggtggacg acacggccat ggctttccgc ctgctacggc tgcacggata     2220

cagcgtctcg ccaggtacgt aacaaacaca aaaaaaaaaa acgcgcagac aacagagatc     2280

gtcacgtcat acacacgcgt gtcctgaaca tttttcattt ggtctcccac ccatcgtacg     2340

taataataat aaaaaaaaac gtgcttctgc cctgcctgtg tacgtgtaga tgtgttcaag     2400

aacttcgaga aggacgggga gttcttcgcc ttcgtggggc agtcgaacca ggcggtgacg     2460

gggatgtaca acctcaacag ggcctcccag ataagcttcc cgggggagga cgtcctgcac     2520

cgtgcagggg ctttctcgta cgagtttctc aggcggaaag aggccgaggg agcgctccgt     2580

gacaaatgga tcatatctaa ggacctgcct ggggaggtag tgtacaccct ggacttccct     2640

tggtatggga acctgccgcg cgtggaggcg agagactatc tggaacagta cggcggcggc     2700

gacgatgtct ggatcgggaa gacgctctac aggtagatag atctttttag ctattaattg     2760

gtttcagatc gaccagataa aatttgcatt attggttctt ttgatgcatg taattgaaag     2820

ccaataaata acctcagtat gcgtgatggc tgacttttgc attggcagga tgcctcttgt     2880

gaataacgat gtgtatcttg agctggctag gatggacttc aaccattgcc aagccctaca     2940

tcagcttgag tggcaaggcc tgaaaaggta tgtatgttac tatatatata cagcccggtt     3000

gttgagtttt ttttttattt tatttttttc gcgattacca tttcttctcg atgcaaaata     3060

aatctgcaca gatcatcata tatatccttg atgatatata agggcttctc gtatatatat     3120

cttatcacct atatatacat aggtggtaca ctgagaaccg gctcatggat ttcggagtgg     3180

cgcaagagga tgctctgcga gcgtatttcc tggccgccgc ttccgtctac gagccgtgcc     3240

gagccgcgga gcggcttgcg tgggccagag cggcgatact tgccaacgcc gtctctaccc     3300

atctccgtaa cagcccctca ttcagagaac gcttggaaca ctccttgcgt tgccgcccca     3360

gtgaagaaac ggatggatca tggtaataag ctgatcgatg ggaaattaaa aatttaagtt     3420

ttttttttct tttttgttgc cattatctga gaccaatgca atgtggtgca tatatatcca     3480

ggttcaactc atcaagtgga agtgacgctg ttcttgtgaa ggcagttctg cggcttaccg     3540

actcgttagc gcgagaagcg cagccgattc atggcggtga tccggaggac atcatccaca     3600

agctactgag atcagctgta agttaaacgt aacgttcaga agaagatttt tttttttttt     3660

tgcagttaac aagtactacg acatctatcg tttttgttca gcatgcacag tcatcctagc     3720

tactaatacc attattcttc tgtgaacttg tgtagtgggc tgaatgggtc agggagaagg     3780

cagatgcagc agacagcgtg tgtaatggat ccagtgctgt ggaacaagaa gggtcgcgca     3840

tggttcatga caagcaaacg tgtctgcttt tagctcgaat gatcgagatc agcgctgggc     3900

gagctgcagg tgaggctgcg agcgaagatg gtgaccgtcg gattatccag ctcactgggt     3960

ctatatgtga cagtctcaag cagaagatgc tagtatctca ggtatagcac atatatacta     4020

cagaaagttt gtgcgtagtt attatttccc ttttttcatg tgacgaacat gatgacctga     4080

tgatgcatgt atatggcttc atataggacc ccgagaagaa cgaagagatg atgagccatg     4140

tcgatgacga attgaagctg cgtatacgag agttcgttca gtatcttctg agactcggtg     4200

agaagaaaac cggcagcagc gagacaaggc agacctttct gagcatcgtg aaaagctgtt     4260

actacgctgc tcactgcccg ccgcatgtgg tagacaggca tatttccaga gttatttttg     4320

aacctgtttc cgccgcaaaa taatggtaat ggtagatgtg aatgtgatat ggagataaga     4380

gagagagaaa atgttgatag tggaaattgg cgttgatgtc gcctccacat tctttacgca     4440

aaagtagcgt ctgttttgga taaaaaaaat ccagtttctg taaattatag aataaatcaa     4500

tcgctgtgtc ccaaactcta aaatgttatt ctgtgaagta tggaataaat cggtcactat     4560

acctatcttg tggatgc                                                    4577


<210>  37
<211>  827
<212>  PRT
<213>  Zea mays

<400>  37

Met Val Leu Ser Ser Ser Cys Thr Thr Val Pro His Leu Ser Ser Leu 
1               5                   10                  15      


Ala Val Val Gln Leu Gly Pro Trp Ser Ser Arg Ile Lys Lys Lys Thr 
            20                  25                  30          


Asp Thr Val Ala Val Pro Ala Ala Ala Gly Arg Trp Arg Arg Ala Leu 
        35                  40                  45              


Ala Arg Ala Gln His Thr Ser Glu Ser Ala Ala Val Ala Lys Gly Ser 
    50                  55                  60                  


Ser Leu Thr Pro Ile Val Arg Thr Asp Ala Glu Ser Arg Arg Thr Arg 
65                  70                  75                  80  


Trp Pro Thr Asp Asp Asp Asp Ala Glu Pro Leu Val Asp Glu Ile Arg 
                85                  90                  95      


Ala Met Leu Thr Ser Met Ser Asp Gly Asp Ile Ser Val Ser Ala Tyr 
            100                 105                 110         


Asp Thr Ala Trp Val Gly Leu Val Pro Arg Leu Asp Gly Gly Glu Gly 
        115                 120                 125             


Pro Gln Phe Pro Ala Ala Val Arg Trp Ile Arg Asn Asn Gln Leu Pro 
    130                 135                 140                 


Asp Gly Ser Trp Gly Asp Ala Ala Leu Phe Ser Ala Tyr Asp Arg Leu 
145                 150                 155                 160 


Ile Asn Thr Leu Ala Cys Val Val Thr Leu Thr Arg Trp Ser Leu Glu 
                165                 170                 175     


Pro Glu Met Arg Gly Arg Gly Leu Ser Phe Leu Gly Arg Asn Met Trp 
            180                 185                 190         


Lys Leu Ala Thr Glu Asp Glu Glu Ser Met Pro Ile Gly Phe Glu Leu 
        195                 200                 205             


Ala Phe Pro Ser Leu Ile Glu Leu Ala Lys Ser Leu Gly Val His Asp 
    210                 215                 220                 


Phe Pro Tyr Asp His Gln Ala Leu Gln Gly Ile Tyr Ser Ser Arg Glu 
225                 230                 235                 240 


Ile Lys Met Lys Arg Ile Pro Lys Glu Val Met His Thr Val Pro Thr 
                245                 250                 255     


Ser Ile Leu His Ser Leu Glu Gly Met Pro Gly Leu Asp Trp Ala Lys 
            260                 265                 270         


Leu Leu Lys Leu Gln Ser Ser Asp Gly Ser Phe Leu Phe Ser Pro Ala 
        275                 280                 285             


Ala Thr Ala Tyr Ala Leu Met Asn Thr Gly Asp Asp Arg Cys Phe Ser 
    290                 295                 300                 


Tyr Ile Asp Arg Thr Val Lys Lys Phe Asn Gly Gly Val Pro Asn Val 
305                 310                 315                 320 


Tyr Pro Val Asp Leu Phe Glu His Ile Trp Ala Val Asp Arg Leu Glu 
                325                 330                 335     


Arg Leu Gly Ile Ser Arg Tyr Phe Gln Lys Glu Ile Glu Gln Cys Met 
            340                 345                 350         


Asp Tyr Val Asn Arg His Trp Thr Glu Asp Gly Ile Cys Trp Ala Arg 
        355                 360                 365             


Asn Ser Asp Val Lys Glu Val Asp Asp Thr Ala Met Ala Phe Arg Leu 
    370                 375                 380                 


Leu Arg Leu His Gly Tyr Ser Val Ser Pro Asp Val Phe Lys Asn Phe 
385                 390                 395                 400 


Glu Lys Asp Gly Glu Phe Phe Ala Phe Val Gly Gln Ser Asn Gln Ala 
                405                 410                 415     


Val Thr Gly Met Tyr Asn Leu Asn Arg Ala Ser Gln Ile Ser Phe Pro 
            420                 425                 430         


Gly Glu Asp Val Leu His Arg Ala Gly Ala Phe Ser Tyr Glu Phe Leu 
        435                 440                 445             


Arg Arg Lys Glu Ala Glu Gly Ala Leu Arg Asp Lys Trp Ile Ile Ser 
    450                 455                 460                 


Lys Asp Leu Pro Gly Glu Val Val Tyr Thr Leu Asp Phe Pro Trp Tyr 
465                 470                 475                 480 


Gly Asn Leu Pro Arg Val Glu Ala Arg Asp Tyr Leu Glu Gln Tyr Gly 
                485                 490                 495     


Gly Gly Asp Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Pro Leu 
            500                 505                 510         


Val Asn Asn Asp Val Tyr Leu Glu Leu Ala Arg Met Asp Phe Asn His 
        515                 520                 525             


Cys Gln Ala Leu His Gln Leu Glu Trp Gln Gly Leu Lys Arg Trp Tyr 
    530                 535                 540                 


Thr Glu Asn Arg Leu Met Asp Phe Gly Val Ala Gln Glu Asp Ala Leu 
545                 550                 555                 560 


Arg Ala Tyr Phe Leu Ala Ala Ala Ser Val Tyr Glu Pro Cys Arg Ala 
                565                 570                 575     


Ala Glu Arg Leu Ala Trp Ala Arg Ala Ala Ile Leu Ala Asn Ala Val 
            580                 585                 590         


Ser Thr His Leu Arg Asn Ser Pro Ser Phe Arg Glu Arg Leu Glu His 
        595                 600                 605             


Ser Leu Arg Cys Arg Pro Ser Glu Glu Thr Asp Gly Ser Trp Phe Asn 
    610                 615                 620                 


Ser Ser Ser Gly Ser Asp Ala Val Leu Val Lys Ala Val Leu Arg Leu 
625                 630                 635                 640 


Thr Asp Ser Leu Ala Arg Glu Ala Gln Pro Ile His Gly Gly Asp Pro 
                645                 650                 655     


Glu Asp Ile Ile His Lys Leu Leu Arg Ser Ala Trp Ala Glu Trp Val 
            660                 665                 670         


Arg Glu Lys Ala Asp Ala Ala Asp Ser Val Cys Asn Gly Ser Ser Ala 
        675                 680                 685             


Val Glu Gln Glu Gly Ser Arg Met Val His Asp Lys Gln Thr Cys Leu 
    690                 695                 700                 


Leu Leu Ala Arg Met Ile Glu Ile Ser Ala Gly Arg Ala Ala Gly Glu 
705                 710                 715                 720 


Ala Ala Ser Glu Asp Gly Asp Arg Arg Ile Ile Gln Leu Thr Gly Ser 
                725                 730                 735     


Ile Cys Asp Ser Leu Lys Gln Lys Met Leu Val Ser Gln Asp Pro Glu 
            740                 745                 750         


Lys Asn Glu Glu Met Met Ser His Val Asp Asp Glu Leu Lys Leu Arg 
        755                 760                 765             


Ile Arg Glu Phe Val Gln Tyr Leu Leu Arg Leu Gly Glu Lys Lys Thr 
    770                 775                 780                 


Gly Ser Ser Glu Thr Arg Gln Thr Phe Leu Ser Ile Val Lys Ser Cys 
785                 790                 795                 800 


Tyr Tyr Ala Ala His Cys Pro Pro His Val Val Asp Arg His Ile Ser 
                805                 810                 815     


Arg Val Ile Phe Glu Pro Val Ser Ala Ala Lys 
            820                 825         


<210>  38
<211>  2570
<212>  DNA
<213>  Arabidopsis thaliana

<400>  38
cttcttcact aaatacttag acagagaaaa cagagctttt taaagccatg tctcttcagt       60

atcatgttct aaactccatt ccaagtacaa cctttctcag ttctactaaa acaacaatat      120

cttcttcttt ccttaccatc tcaggatctc ctctcaatgt cgctagagac aaatccagaa      180

gcggttccat acattgttca aagcttcgaa ctcaagaata cattaattct caagaggttc      240

aacatgattt gcctctaata catgagtggc aacagcttca aggagaagat gctcctcaga      300

ttagtgttgg aagtaatagt aatgcattca aagaagcagt gaagagtgtg aaaacgatct      360

tgagaaacct aacggacggg gaaattacga tatcggctta cgatacagct tgggttgcat      420

tgatcgatgc cggagataaa actccggcgt ttccctccgc cgtgaaatgg atcgccgaga      480

accaactttc cgatggttct tggggagatg cgtatctctt ctcttatcat gatcgtctca      540

tcaataccct tgcatgcgtc gttgctctaa gatcatggaa tctctttcct catcaatgca      600

acaaaggaat cacgtttttc cgggaaaata ttgggaagct agaagacgaa aatgatgagc      660

atatgccaat cggattcgaa gtagcattcc catcgttgct tgagatagct cgaggaataa      720

acattgatgt accgtacgat tctccggtct taaaagatat atacgccaag aaagagctaa      780

agcttacaag gataccaaaa gagataatgc acaagatacc aacaacattg ttgcatagtt      840

tggaggggat gcgtgattta gattgggaaa agctcttgaa acttcaatct caagacggat      900

ctttcctctt ctctccttcc tctaccgctt ttgcattcat gcagacccga gacagtaact      960

gcctcgagta tttgcgaaat gccgtcaaac gtttcaatgg aggagttccc aatgtctttc     1020

ccgtggatct tttcgagcac atatggatag tggatcggtt acaacgttta gggatatcga     1080

gatactttga agaagagatt aaagagtgtc ttgactatgt ccacagatat tggaccgaca     1140

atggcatatg ttgggctaga tgttcccatg tccaagacat cgatgataca gccatggcat     1200

ttaggctctt aagacaacat ggataccaag tgtccgcaga tgtattcaag aactttgaga     1260

aagagggaga gtttttctgc tttgtggggc aatcaaacca agcagtaacc ggtatgttca     1320

acctataccg ggcatcacaa ttggcgtttc caagggaaga gatattgaaa aacgccaaag     1380

agttttctta taattatctg ctagaaaaac gggagagaga ggagttgatt gataagtgga     1440

ttataatgaa agacttacct ggcgagattg ggtttgcgtt agagattcca tggtacgcaa     1500

gcttgcctcg agtagagacg agattctata ttgatcaata tggtggagaa aacgacgttt     1560

ggattggcaa gactctttat aggatgccat acgtgaacaa taatggatat ctggaattag     1620

caaaacaaga ttacaacaat tgccaagctc agcatcagct cgaatgggac atattccaaa     1680

agtggtatga agaaaatagg ttaagtgagt ggggtgtgcg cagaagtgag cttctcgagt     1740

gttactactt agcggctgca actatatttg aatcagaaag gtcacatgag agaatggttt     1800

gggctaagtc aagtgtattg gttaaagcca tttcttcttc ttttggggaa tcctctgact     1860

ccagaagaag cttctccgat cagtttcatg aatacattgc caatgctcga cgaagtgatc     1920

atcactttaa tgacaggaac atgagattgg accgaccagg atcggttcag gccagtcggc     1980

ttgccggagt gttaatcggg actttgaatc aaatgtcttt tgaccttttc atgtctcatg     2040

gccgtgacgt taacaatctc ctctatctat cgtggggaga ttggatggaa aaatggaaac     2100

tatatggaga tgaaggagaa ggagagctca tggtgaagat gataattcta atgaagaaca     2160

atgacctaac taacttcttc acccacactc acttcgttcg tctcgcggaa atcatcaatc     2220

gaatctgtct tcctcgccaa tacttaaagg caaggagaaa cgatgagaag gagaagacaa     2280

taaagagtat ggagaaggag atggggaaaa tggttgagtt agcattgtcg gagagtgaca     2340

catttcgtga cgtcagcatc acgtttcttg atgtagcaaa agcattttac tactttgctt     2400

tatgtggcga tcatctccaa actcacatct ccaaagtctt gtttcaaaaa gtctagtaac     2460

ctcatcatca tcatcgatcc attaacaatc agtggatcga tgtatccata gatgcgtgaa     2520

taatatttca tgtagagaag gagaacaaat tagatcatgt agggttatca                2570


<210>  39
<211>  802
<212>  PRT
<213>  Arabidopsis thaliana

<400>  39

Met Ser Leu Gln Tyr His Val Leu Asn Ser Ile Pro Ser Thr Thr Phe 
1               5                   10                  15      


Leu Ser Ser Thr Lys Thr Thr Ile Ser Ser Ser Phe Leu Thr Ile Ser 
            20                  25                  30          


Gly Ser Pro Leu Asn Val Ala Arg Asp Lys Ser Arg Ser Gly Ser Ile 
        35                  40                  45              


His Cys Ser Lys Leu Arg Thr Gln Glu Tyr Ile Asn Ser Gln Glu Val 
    50                  55                  60                  


Gln His Asp Leu Pro Leu Ile His Glu Trp Gln Gln Leu Gln Gly Glu 
65                  70                  75                  80  


Asp Ala Pro Gln Ile Ser Val Gly Ser Asn Ser Asn Ala Phe Lys Glu 
                85                  90                  95      


Ala Val Lys Ser Val Lys Thr Ile Leu Arg Asn Leu Thr Asp Gly Glu 
            100                 105                 110         


Ile Thr Ile Ser Ala Tyr Asp Thr Ala Trp Val Ala Leu Ile Asp Ala 
        115                 120                 125             


Gly Asp Lys Thr Pro Ala Phe Pro Ser Ala Val Lys Trp Ile Ala Glu 
    130                 135                 140                 


Asn Gln Leu Ser Asp Gly Ser Trp Gly Asp Ala Tyr Leu Phe Ser Tyr 
145                 150                 155                 160 


His Asp Arg Leu Ile Asn Thr Leu Ala Cys Val Val Ala Leu Arg Ser 
                165                 170                 175     


Trp Asn Leu Phe Pro His Gln Cys Asn Lys Gly Ile Thr Phe Phe Arg 
            180                 185                 190         


Glu Asn Ile Gly Lys Leu Glu Asp Glu Asn Asp Glu His Met Pro Ile 
        195                 200                 205             


Gly Phe Glu Val Ala Phe Pro Ser Leu Leu Glu Ile Ala Arg Gly Ile 
    210                 215                 220                 


Asn Ile Asp Val Pro Tyr Asp Ser Pro Val Leu Lys Asp Ile Tyr Ala 
225                 230                 235                 240 


Lys Lys Glu Leu Lys Leu Thr Arg Ile Pro Lys Glu Ile Met His Lys 
                245                 250                 255     


Ile Pro Thr Thr Leu Leu His Ser Leu Glu Gly Met Arg Asp Leu Asp 
            260                 265                 270         


Trp Glu Lys Leu Leu Lys Leu Gln Ser Gln Asp Gly Ser Phe Leu Phe 
        275                 280                 285             


Ser Pro Ser Ser Thr Ala Phe Ala Phe Met Gln Thr Arg Asp Ser Asn 
    290                 295                 300                 


Cys Leu Glu Tyr Leu Arg Asn Ala Val Lys Arg Phe Asn Gly Gly Val 
305                 310                 315                 320 


Pro Asn Val Phe Pro Val Asp Leu Phe Glu His Ile Trp Ile Val Asp 
                325                 330                 335     


Arg Leu Gln Arg Leu Gly Ile Ser Arg Tyr Phe Glu Glu Glu Ile Lys 
            340                 345                 350         


Glu Cys Leu Asp Tyr Val His Arg Tyr Trp Thr Asp Asn Gly Ile Cys 
        355                 360                 365             


Trp Ala Arg Cys Ser His Val Gln Asp Ile Asp Asp Thr Ala Met Ala 
    370                 375                 380                 


Phe Arg Leu Leu Arg Gln His Gly Tyr Gln Val Ser Ala Asp Val Phe 
385                 390                 395                 400 


Lys Asn Phe Glu Lys Glu Gly Glu Phe Phe Cys Phe Val Gly Gln Ser 
                405                 410                 415     


Asn Gln Ala Val Thr Gly Met Phe Asn Leu Tyr Arg Ala Ser Gln Leu 
            420                 425                 430         


Ala Phe Pro Arg Glu Glu Ile Leu Lys Asn Ala Lys Glu Phe Ser Tyr 
        435                 440                 445             


Asn Tyr Leu Leu Glu Lys Arg Glu Arg Glu Glu Leu Ile Asp Lys Trp 
    450                 455                 460                 


Ile Ile Met Lys Asp Leu Pro Gly Glu Ile Gly Phe Ala Leu Glu Ile 
465                 470                 475                 480 


Pro Trp Tyr Ala Ser Leu Pro Arg Val Glu Thr Arg Phe Tyr Ile Asp 
                485                 490                 495     


Gln Tyr Gly Gly Glu Asn Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg 
            500                 505                 510         


Met Pro Tyr Val Asn Asn Asn Gly Tyr Leu Glu Leu Ala Lys Gln Asp 
        515                 520                 525             


Tyr Asn Asn Cys Gln Ala Gln His Gln Leu Glu Trp Asp Ile Phe Gln 
    530                 535                 540                 


Lys Trp Tyr Glu Glu Asn Arg Leu Ser Glu Trp Gly Val Arg Arg Ser 
545                 550                 555                 560 


Glu Leu Leu Glu Cys Tyr Tyr Leu Ala Ala Ala Thr Ile Phe Glu Ser 
                565                 570                 575     


Glu Arg Ser His Glu Arg Met Val Trp Ala Lys Ser Ser Val Leu Val 
            580                 585                 590         


Lys Ala Ile Ser Ser Ser Phe Gly Glu Ser Ser Asp Ser Arg Arg Ser 
        595                 600                 605             


Phe Ser Asp Gln Phe His Glu Tyr Ile Ala Asn Ala Arg Arg Ser Asp 
    610                 615                 620                 


His His Phe Asn Asp Arg Asn Met Arg Leu Asp Arg Pro Gly Ser Val 
625                 630                 635                 640 


Gln Ala Ser Arg Leu Ala Gly Val Leu Ile Gly Thr Leu Asn Gln Met 
                645                 650                 655     


Ser Phe Asp Leu Phe Met Ser His Gly Arg Asp Val Asn Asn Leu Leu 
            660                 665                 670         


Tyr Leu Ser Trp Gly Asp Trp Met Glu Lys Trp Lys Leu Tyr Gly Asp 
        675                 680                 685             


Glu Gly Glu Gly Glu Leu Met Val Lys Met Ile Ile Leu Met Lys Asn 
    690                 695                 700                 


Asn Asp Leu Thr Asn Phe Phe Thr His Thr His Phe Val Arg Leu Ala 
705                 710                 715                 720 


Glu Ile Ile Asn Arg Ile Cys Leu Pro Arg Gln Tyr Leu Lys Ala Arg 
                725                 730                 735     


Arg Asn Asp Glu Lys Glu Lys Thr Ile Lys Ser Met Glu Lys Glu Met 
            740                 745                 750         


Gly Lys Met Val Glu Leu Ala Leu Ser Glu Ser Asp Thr Phe Arg Asp 
        755                 760                 765             


Val Ser Ile Thr Phe Leu Asp Val Ala Lys Ala Phe Tyr Tyr Phe Ala 
    770                 775                 780                 


Leu Cys Gly Asp His Leu Gln Thr His Ile Ser Lys Val Leu Phe Gln 
785                 790                 795                 800 


Lys Val 
        


<210>  40
<211>  983
<212>  PRT
<213>  Diaporthe amygdali

<400>  40

Met Glu Phe Asp Glu Pro Leu Val Asp Glu Ala Arg Ser Leu Val Gln 
1               5                   10                  15      


Arg Thr Leu Gln Asp Tyr Asp Asp Arg Tyr Gly Phe Gly Thr Met Ser 
            20                  25                  30          


Cys Ala Ala Tyr Asp Thr Ala Trp Val Ser Leu Val Thr Lys Thr Val 
        35                  40                  45              


Asp Gly Arg Lys Gln Trp Leu Phe Pro Glu Cys Phe Glu Phe Leu Leu 
    50                  55                  60                  


Glu Thr Gln Ser Asp Ala Gly Gly Trp Glu Ile Gly Asn Ser Ala Pro 
65                  70                  75                  80  


Ile Asp Gly Ile Leu Asn Thr Ala Ala Ser Leu Leu Ala Leu Lys Arg 
                85                  90                  95      


His Val Gln Thr Glu Gln Ile Ile Gln Pro Gln His Asp His Lys Asp 
            100                 105                 110         


Leu Ala Gly Arg Ala Glu Arg Ala Ala Ala Ser Leu Arg Ala Gln Leu 
        115                 120                 125             


Ala Ala Leu Asp Val Ser Thr Thr Glu His Val Gly Phe Glu Ile Ile 
    130                 135                 140                 


Val Pro Ala Met Leu Asp Pro Leu Glu Ala Glu Asp Pro Ser Leu Val 
145                 150                 155                 160 


Phe Asp Phe Pro Ala Arg Lys Pro Leu Met Lys Ile His Asp Ala Lys 
                165                 170                 175     


Met Ser Arg Phe Arg Pro Glu Tyr Leu Tyr Gly Lys Gln Pro Met Thr 
            180                 185                 190         


Ala Leu His Ser Leu Glu Ala Phe Ile Gly Lys Ile Asp Phe Asp Lys 
        195                 200                 205             


Val Arg His His Arg Thr His Gly Ser Met Met Gly Ser Pro Ser Ser 
    210                 215                 220                 


Thr Ala Ala Tyr Leu Met His Ala Ser Gln Trp Asp Gly Asp Ser Glu 
225                 230                 235                 240 


Ala Tyr Leu Arg His Val Ile Lys His Ala Ala Gly Gln Gly Thr Gly 
                245                 250                 255     


Ala Val Pro Ser Ala Phe Pro Ser Thr His Phe Glu Ser Ser Trp Ile 
            260                 265                 270         


Leu Thr Thr Leu Phe Arg Ala Gly Phe Ser Ala Ser His Leu Ala Cys 
        275                 280                 285             


Asp Glu Leu Asn Lys Leu Val Glu Ile Leu Glu Gly Ser Phe Glu Lys 
    290                 295                 300                 


Glu Gly Gly Ala Ile Gly Tyr Ala Pro Gly Phe Gln Ala Asp Val Asp 
305                 310                 315                 320 


Asp Thr Ala Lys Thr Ile Ser Thr Leu Ala Val Leu Gly Arg Asp Ala 
                325                 330                 335     


Thr Pro Arg Gln Met Ile Lys Val Phe Glu Ala Asn Thr His Phe Arg 
            340                 345                 350         


Thr Tyr Pro Gly Glu Arg Asp Pro Ser Leu Thr Ala Asn Cys Asn Ala 
        355                 360                 365             


Leu Ser Ala Leu Leu His Gln Pro Asp Ala Ala Met Tyr Gly Ser Gln 
    370                 375                 380                 


Ile Gln Lys Ile Thr Lys Phe Val Cys Asp Tyr Trp Trp Lys Ser Asp 
385                 390                 395                 400 


Gly Lys Ile Lys Asp Lys Trp Asn Thr Cys Tyr Leu Tyr Pro Ser Val 
                405                 410                 415     


Leu Leu Val Glu Val Leu Val Asp Leu Val Ser Leu Leu Glu Gln Gly 
            420                 425                 430         


Lys Leu Pro Asp Val Leu Asp Gln Glu Leu Gln Tyr Arg Val Ala Ile 
        435                 440                 445             


Thr Leu Phe Gln Ala Cys Leu Arg Pro Leu Leu Asp Gln Asp Ala Glu 
    450                 455                 460                 


Gly Ser Trp Asn Lys Ser Ile Glu Ala Thr Ala Tyr Gly Ile Leu Ile 
465                 470                 475                 480 


Leu Thr Glu Ala Arg Arg Val Cys Phe Phe Asp Arg Leu Ser Glu Pro 
                485                 490                 495     


Leu Asn Glu Ala Ile Arg Arg Gly Ile Ala Phe Ala Asp Ser Met Ser 
            500                 505                 510         


Gly Thr Glu Ala Gln Leu Asn Tyr Ile Trp Ile Glu Lys Val Ser Tyr 
        515                 520                 525             


Ala Pro Ala Leu Leu Thr Lys Ser Tyr Leu Leu Ala Ala Arg Trp Ala 
    530                 535                 540                 


Ala Lys Ser Pro Leu Gly Ala Ser Val Gly Ser Ser Leu Trp Thr Pro 
545                 550                 555                 560 


Pro Arg Glu Gly Leu Asp Lys His Val Arg Leu Phe His Gln Ala Glu 
                565                 570                 575     


Leu Phe Arg Ser Leu Pro Glu Trp Glu Leu Arg Ala Ser Met Ile Glu 
            580                 585                 590         


Ala Ala Leu Phe Thr Pro Leu Leu Arg Ala His Arg Leu Asp Val Phe 
        595                 600                 605             


Pro Arg Gln Asp Val Gly Glu Asp Lys Tyr Leu Asp Val Val Pro Phe 
    610                 615                 620                 


Phe Trp Thr Ala Ala Asn Asn Arg Asp Arg Thr Tyr Ala Ser Thr Leu 
625                 630                 635                 640 


Phe Leu Tyr Asp Met Cys Phe Ile Ala Met Leu Asn Phe Gln Leu Asp 
                645                 650                 655     


Glu Phe Met Glu Ala Thr Ala Gly Ile Leu Phe Arg Asp His Met Asp 
            660                 665                 670         


Asp Leu Arg Gln Leu Ile His Asp Leu Leu Ala Glu Lys Thr Ser Pro 
        675                 680                 685             


Lys Ser Ser Gly Arg Ser Ser Gln Gly Thr Lys Asp Ala Asp Ser Gly 
    690                 695                 700                 


Ile Glu Glu Asp Val Ser Met Ser Asp Ser Ala Ser Asp Ser Gln Asp 
705                 710                 715                 720 


Arg Ser Pro Glu Tyr Asp Leu Val Phe Ser Ala Leu Ser Thr Phe Thr 
                725                 730                 735     


Lys His Val Leu Gln His Pro Ser Ile Gln Ser Ala Ser Val Trp Asp 
            740                 745                 750         


Arg Lys Leu Leu Ala Arg Glu Met Lys Ala Tyr Leu Leu Ala His Ile 
        755                 760                 765             


Gln Gln Ala Glu Asp Ser Thr Pro Leu Ser Glu Leu Lys Asp Val Pro 
    770                 775                 780                 


Gln Lys Thr Asp Val Thr Arg Val Ser Thr Ser Thr Thr Thr Phe Phe 
785                 790                 795                 800 


Asn Trp Val Arg Thr Thr Ser Ala Asp His Ile Ser Cys Pro Tyr Ser 
                805                 810                 815     


Phe His Phe Val Ala Cys His Leu Gly Ala Ala Leu Ser Pro Lys Gly 
            820                 825                 830         


Ser Asn Gly Asp Cys Tyr Pro Ser Ala Gly Glu Lys Phe Leu Ala Ala 
        835                 840                 845             


Ala Val Cys Arg His Leu Ala Thr Met Cys Arg Met Tyr Asn Asp Leu 
    850                 855                 860                 


Gly Ser Ala Glu Arg Asp Ser Asp Glu Gly Asn Leu Asn Ser Leu Asp 
865                 870                 875                 880 


Phe Pro Glu Phe Ala Asp Ser Ala Gly Asn Gly Gly Ile Glu Ile Gln 
                885                 890                 895     


Lys Ala Ala Leu Leu Arg Leu Ala Glu Phe Glu Arg Asp Ser Tyr Leu 
            900                 905                 910         


Glu Ala Phe Arg Arg Leu Gln Asp Glu Ser Asn Arg Val His Gly Pro 
        915                 920                 925             


Ala Gly Gly Asp Glu Ala Arg Leu Ser Arg Arg Arg Met Ala Ile Leu 
    930                 935                 940                 


Glu Phe Phe Ala Gln Gln Val Asp Leu Tyr Gly Gln Val Tyr Val Ile 
945                 950                 955                 960 


Arg Asp Ile Ser Ala Arg Ile Pro Lys Asn Glu Val Glu Lys Lys Arg 
                965                 970                 975     


Lys Leu Asp Asp Ala Phe Asn 
            980             


<210>  41
<211>  881
<212>  PRT
<213>  Physcomitrella patens

<400>  41

Met Ala Ser Ser Thr Leu Ile Gln Asn Arg Ser Cys Gly Val Thr Ser 
1               5                   10                  15      


Ser Met Ser Ser Phe Gln Ile Phe Arg Gly Gln Pro Leu Arg Phe Pro 
            20                  25                  30          


Gly Thr Arg Thr Pro Ala Ala Val Gln Cys Leu Lys Lys Arg Arg Cys 
        35                  40                  45              


Leu Arg Pro Thr Glu Ser Val Leu Glu Ser Ser Pro Gly Ser Gly Ser 
    50                  55                  60                  


Tyr Arg Ile Val Thr Gly Pro Ser Gly Ile Asn Pro Ser Ser Asn Gly 
65                  70                  75                  80  


His Leu Gln Glu Gly Ser Leu Thr His Arg Leu Pro Ile Pro Met Glu 
                85                  90                  95      


Lys Ser Ile Asp Asn Phe Gln Ser Thr Leu Tyr Val Ser Asp Ile Trp 
            100                 105                 110         


Ser Glu Thr Leu Gln Arg Thr Glu Cys Leu Leu Gln Val Thr Glu Asn 
        115                 120                 125             


Val Gln Met Asn Glu Trp Ile Glu Glu Ile Arg Met Tyr Phe Arg Asn 
    130                 135                 140                 


Met Thr Leu Gly Glu Ile Ser Met Ser Pro Tyr Asp Thr Ala Trp Val 
145                 150                 155                 160 


Ala Arg Val Pro Ala Leu Asp Gly Ser His Gly Pro Gln Phe His Arg 
                165                 170                 175     


Ser Leu Gln Trp Ile Ile Asp Asn Gln Leu Pro Asp Gly Asp Trp Gly 
            180                 185                 190         


Glu Pro Ser Leu Phe Leu Gly Tyr Asp Arg Val Cys Asn Thr Leu Ala 
        195                 200                 205             


Cys Val Ile Ala Leu Lys Thr Trp Gly Val Gly Ala Gln Asn Val Glu 
    210                 215                 220                 


Arg Gly Ile Gln Phe Leu Gln Ser Asn Ile Tyr Lys Met Glu Glu Asp 
225                 230                 235                 240 


Asp Ala Asn His Met Pro Ile Gly Phe Glu Ile Val Phe Pro Ala Met 
                245                 250                 255     


Met Glu Asp Ala Lys Ala Leu Gly Leu Asp Leu Pro Tyr Asp Ala Thr 
            260                 265                 270         


Ile Leu Gln Gln Ile Ser Ala Glu Arg Glu Lys Lys Met Lys Lys Ile 
        275                 280                 285             


Pro Met Ala Met Val Tyr Lys Tyr Pro Thr Thr Leu Leu His Ser Leu 
    290                 295                 300                 


Glu Gly Leu His Arg Glu Val Asp Trp Asn Lys Leu Leu Gln Leu Gln 
305                 310                 315                 320 


Ser Glu Asn Gly Ser Phe Leu Tyr Ser Pro Ala Ser Thr Ala Cys Ala 
                325                 330                 335     


Leu Met Tyr Thr Lys Asp Val Lys Cys Phe Asp Tyr Leu Asn Gln Leu 
            340                 345                 350         


Leu Ile Lys Phe Asp His Ala Cys Pro Asn Val Tyr Pro Val Asp Leu 
        355                 360                 365             


Phe Glu Arg Leu Trp Met Val Asp Arg Leu Gln Arg Leu Gly Ile Ser 
    370                 375                 380                 


Arg Tyr Phe Glu Arg Glu Ile Arg Asp Cys Leu Gln Tyr Val Tyr Arg 
385                 390                 395                 400 


Tyr Trp Lys Asp Cys Gly Ile Gly Trp Ala Ser Asn Ser Ser Val Gln 
                405                 410                 415     


Asp Val Asp Asp Thr Ala Met Ala Phe Arg Leu Leu Arg Thr His Gly 
            420                 425                 430         


Phe Asp Val Lys Glu Asp Cys Phe Arg Gln Phe Phe Lys Asp Gly Glu 
        435                 440                 445             


Phe Phe Cys Phe Ala Gly Gln Ser Ser Gln Ala Val Thr Gly Met Phe 
    450                 455                 460                 


Asn Leu Ser Arg Ala Ser Gln Thr Leu Phe Pro Gly Glu Ser Leu Leu 
465                 470                 475                 480 


Lys Lys Ala Arg Thr Phe Ser Arg Asn Phe Leu Arg Thr Lys His Glu 
                485                 490                 495     


Asn Asn Glu Cys Phe Asp Lys Trp Ile Ile Thr Lys Asp Leu Ala Gly 
            500                 505                 510         


Glu Val Glu Tyr Asn Leu Thr Phe Pro Trp Tyr Ala Ser Leu Pro Arg 
        515                 520                 525             


Leu Glu His Arg Thr Tyr Leu Asp Gln Tyr Gly Ile Asp Asp Ile Trp 
    530                 535                 540                 


Ile Gly Lys Ser Leu Tyr Lys Met Pro Ala Val Thr Asn Glu Val Phe 
545                 550                 555                 560 


Leu Lys Leu Ala Lys Ala Asp Phe Asn Met Cys Gln Ala Leu His Lys 
                565                 570                 575     


Lys Glu Leu Glu Gln Val Ile Lys Trp Asn Ala Ser Cys Gln Phe Arg 
            580                 585                 590         


Asp Leu Glu Phe Ala Arg Gln Lys Ser Val Glu Cys Tyr Phe Ala Gly 
        595                 600                 605             


Ala Ala Thr Met Phe Glu Pro Glu Met Val Gln Ala Arg Leu Val Trp 
    610                 615                 620                 


Ala Arg Cys Cys Val Leu Thr Thr Val Leu Asp Asp Tyr Phe Asp His 
625                 630                 635                 640 


Gly Thr Pro Val Glu Glu Leu Arg Val Phe Val Gln Ala Val Arg Thr 
                645                 650                 655     


Trp Asn Pro Glu Leu Ile Asn Gly Leu Pro Glu Gln Ala Lys Ile Leu 
            660                 665                 670         


Phe Met Gly Leu Tyr Lys Thr Val Asn Thr Ile Ala Glu Glu Ala Phe 
        675                 680                 685             


Met Ala Gln Lys Arg Asp Val His His His Leu Lys His Tyr Trp Asp 
    690                 695                 700                 


Lys Leu Ile Thr Ser Ala Leu Lys Glu Ala Glu Trp Ala Glu Ser Gly 
705                 710                 715                 720 


Tyr Val Pro Thr Phe Asp Glu Tyr Met Glu Val Ala Glu Ile Ser Val 
                725                 730                 735     


Ala Leu Glu Pro Ile Val Cys Ser Thr Leu Phe Phe Ala Gly His Arg 
            740                 745                 750         


Leu Asp Glu Asp Val Leu Asp Ser Tyr Asp Tyr His Leu Val Met His 
        755                 760                 765             


Leu Val Asn Arg Val Gly Arg Ile Leu Asn Asp Ile Gln Gly Met Lys 
    770                 775                 780                 


Arg Glu Ala Ser Gln Gly Lys Ile Ser Ser Val Gln Ile Tyr Met Glu 
785                 790                 795                 800 


Glu His Pro Ser Val Pro Ser Glu Ala Met Ala Ile Ala His Leu Gln 
                805                 810                 815     


Glu Leu Val Asp Asn Ser Met Gln Gln Leu Thr Tyr Glu Val Leu Arg 
            820                 825                 830         


Phe Thr Ala Val Pro Lys Ser Cys Lys Arg Ile His Leu Asn Met Ala 
        835                 840                 845             


Lys Ile Met His Ala Phe Tyr Lys Asp Thr Asp Gly Phe Ser Ser Leu 
    850                 855                 860                 


Thr Ala Met Thr Gly Phe Val Lys Lys Val Leu Phe Glu Pro Val Pro 
865                 870                 875                 880 


Glu 
    


<210>  42
<211>  952
<212>  PRT
<213>  Fusarium fujikuroi

<400>  42

Met Pro Gly Lys Ile Glu Asn Gly Thr Pro Lys Asp Leu Lys Thr Gly 
1               5                   10                  15      


Asn Asp Phe Val Ser Ala Ala Lys Ser Leu Leu Asp Arg Ala Phe Lys 
            20                  25                  30          


Ser His His Ser Tyr Tyr Gly Leu Cys Ser Thr Ser Cys Gln Val Tyr 
        35                  40                  45              


Asp Thr Ala Trp Val Ala Met Ile Pro Lys Thr Arg Asp Asn Val Lys 
    50                  55                  60                  


Gln Trp Leu Phe Pro Glu Cys Phe His Tyr Leu Leu Lys Thr Gln Ala 
65                  70                  75                  80  


Ala Asp Gly Ser Trp Gly Ser Leu Pro Thr Thr Gln Thr Ala Gly Ile 
                85                  90                  95      


Leu Asp Thr Ala Ser Ala Val Leu Ala Leu Leu Cys His Ala Gln Glu 
            100                 105                 110         


Pro Leu Gln Ile Leu Asp Val Ser Pro Asp Glu Met Gly Leu Arg Ile 
        115                 120                 125             


Glu His Gly Val Thr Ser Leu Lys Arg Gln Leu Ala Val Trp Asn Asp 
    130                 135                 140                 


Val Glu Asp Thr Asn His Ile Gly Val Glu Phe Ile Ile Pro Ala Leu 
145                 150                 155                 160 


Leu Ser Met Leu Glu Lys Glu Leu Asp Val Pro Ser Phe Glu Phe Pro 
                165                 170                 175     


Cys Arg Ser Ile Leu Glu Arg Met His Gly Glu Lys Leu Gly His Phe 
            180                 185                 190         


Asp Leu Glu Gln Val Tyr Gly Lys Pro Ser Ser Leu Leu His Ser Leu 
        195                 200                 205             


Glu Ala Phe Leu Gly Lys Leu Asp Phe Asp Arg Leu Ser His His Leu 
    210                 215                 220                 


Tyr His Gly Ser Met Met Ala Ser Pro Ser Ser Thr Ala Ala Tyr Leu 
225                 230                 235                 240 


Ile Gly Ala Thr Lys Trp Asp Asp Glu Ala Glu Asp Tyr Leu Arg His 
                245                 250                 255     


Val Met Arg Asn Gly Ala Gly His Gly Asn Gly Gly Ile Ser Gly Thr 
            260                 265                 270         


Phe Pro Thr Thr His Phe Glu Cys Ser Trp Ile Ile Ala Thr Leu Leu 
        275                 280                 285             


Lys Val Gly Phe Thr Leu Lys Gln Ile Asp Gly Asp Gly Leu Arg Gly 
    290                 295                 300                 


Leu Ser Thr Ile Leu Leu Glu Ala Leu Arg Asp Glu Asn Gly Val Ile 
305                 310                 315                 320 


Gly Phe Ala Pro Arg Thr Ala Asp Val Asp Asp Thr Ala Lys Ala Leu 
                325                 330                 335     


Leu Ala Leu Ser Leu Val Asn Gln Pro Val Ser Pro Asp Ile Met Ile 
            340                 345                 350         


Lys Val Phe Glu Gly Lys Asp His Phe Thr Thr Phe Gly Ser Glu Arg 
        355                 360                 365             


Asp Pro Ser Leu Thr Ser Asn Leu His Val Leu Leu Ser Leu Leu Lys 
    370                 375                 380                 


Gln Ser Asn Leu Ser Gln Tyr His Pro Gln Ile Leu Lys Thr Thr Leu 
385                 390                 395                 400 


Phe Thr Cys Arg Trp Trp Trp Gly Ser Asp His Cys Val Lys Asp Lys 
                405                 410                 415     


Trp Asn Leu Ser His Leu Tyr Pro Thr Met Leu Leu Val Glu Ala Phe 
            420                 425                 430         


Thr Glu Val Leu His Leu Ile Asp Gly Gly Glu Leu Ser Ser Leu Phe 
        435                 440                 445             


Asp Glu Ser Phe Lys Cys Lys Ile Gly Leu Ser Ile Phe Gln Ala Val 
    450                 455                 460                 


Leu Arg Ile Ile Leu Thr Gln Asp Asn Asp Gly Ser Trp Arg Gly Tyr 
465                 470                 475                 480 


Arg Glu Gln Thr Cys Tyr Ala Ile Leu Ala Leu Val Gln Ala Arg His 
                485                 490                 495     


Val Cys Phe Phe Thr His Met Val Asp Arg Leu Gln Ser Cys Val Asp 
            500                 505                 510         


Arg Gly Phe Ser Trp Leu Lys Ser Cys Ser Phe His Ser Gln Asp Leu 
        515                 520                 525             


Thr Trp Thr Ser Lys Thr Ala Tyr Glu Val Gly Phe Val Ala Glu Ala 
    530                 535                 540                 


Tyr Lys Leu Ala Ala Leu Gln Ser Ala Ser Leu Glu Val Pro Ala Ala 
545                 550                 555                 560 


Thr Ile Gly His Ser Val Thr Ser Ala Val Pro Ser Ser Asp Leu Glu 
                565                 570                 575     


Lys Tyr Met Arg Leu Val Arg Lys Thr Ala Leu Phe Ser Pro Leu Asp 
            580                 585                 590         


Glu Trp Gly Leu Met Ala Ser Ile Ile Glu Ser Ser Phe Phe Val Pro 
        595                 600                 605             


Leu Leu Gln Ala Gln Arg Val Glu Ile Tyr Pro Arg Asp Asn Ile Lys 
    610                 615                 620                 


Val Asp Glu Asp Lys Tyr Leu Ser Ile Ile Pro Phe Thr Trp Val Gly 
625                 630                 635                 640 


Cys Asn Asn Arg Ser Arg Thr Phe Ala Ser Asn Arg Trp Leu Tyr Asp 
                645                 650                 655     


Met Met Tyr Leu Ser Leu Leu Gly Tyr Gln Thr Asp Glu Tyr Met Glu 
            660                 665                 670         


Ala Val Ala Gly Pro Val Phe Gly Asp Val Ser Leu Leu His Gln Thr 
        675                 680                 685             


Ile Asp Lys Val Ile Asp Asn Thr Met Gly Asn Leu Ala Arg Ala Asn 
    690                 695                 700                 


Gly Thr Val His Ser Gly Asn Gly His Gln His Glu Ser Pro Asn Ile 
705                 710                 715                 720 


Gly Gln Val Glu Asp Thr Leu Thr Arg Phe Thr Asn Ser Val Leu Asn 
                725                 730                 735     


His Lys Asp Val Leu Asn Ser Ser Ser Ser Asp Gln Asp Thr Leu Arg 
            740                 745                 750         


Arg Glu Phe Arg Thr Phe Met His Ala His Ile Thr Gln Ile Glu Asp 
        755                 760                 765             


Asn Ser Arg Phe Ser Lys Gln Ala Ser Ser Asp Ala Phe Ser Ser Pro 
    770                 775                 780                 


Glu Gln Ser Tyr Phe Gln Trp Val Asn Ser Thr Gly Gly Ser His Val 
785                 790                 795                 800 


Ala Cys Ala Tyr Ser Phe Ala Phe Ser Asn Cys Leu Met Ser Ala Asn 
                805                 810                 815     


Leu Leu Gln Gly Lys Asp Ala Phe Pro Ser Gly Thr Gln Lys Tyr Leu 
            820                 825                 830         


Ile Ser Ser Val Met Arg His Ala Thr Asn Met Cys Arg Met Tyr Asn 
        835                 840                 845             


Asp Phe Gly Ser Ile Ala Arg Asp Asn Ala Glu Arg Asn Val Asn Ser 
    850                 855                 860                 


Ile His Phe Pro Glu Phe Thr Leu Cys Asn Gly Thr Ser Gln Asn Leu 
865                 870                 875                 880 


Asp Glu Arg Lys Glu Arg Leu Leu Lys Ile Ala Thr Tyr Glu Gln Gly 
                885                 890                 895     


Tyr Leu Asp Arg Ala Leu Glu Ala Leu Glu Arg Gln Ser Arg Asp Asp 
            900                 905                 910         


Ala Gly Asp Arg Ala Gly Ser Lys Asp Met Arg Lys Leu Lys Ile Val 
        915                 920                 925             


Lys Leu Phe Cys Asp Val Thr Asp Leu Tyr Asp Gln Leu Tyr Val Ile 
    930                 935                 940                 


Lys Asp Leu Ser Ser Ser Met Lys 
945                 950         


<210>  43
<211>  361
<212>  PRT
<213>  Stevia rebaudiana

<400>  43

Met Ala Leu Val Asn Pro Thr Ala Leu Phe Tyr Gly Thr Ser Ile Arg 
1               5                   10                  15      


Thr Arg Pro Thr Asn Leu Leu Asn Pro Thr Gln Lys Leu Arg Pro Val 
            20                  25                  30          


Ser Ser Ser Ser Leu Pro Ser Phe Ser Ser Val Ser Ala Ile Leu Thr 
        35                  40                  45              


Glu Lys His Gln Ser Asn Pro Ser Glu Asn Asn Asn Leu Gln Thr His 
    50                  55                  60                  


Leu Glu Thr Pro Phe Asn Phe Asp Ser Tyr Met Leu Glu Lys Val Asn 
65                  70                  75                  80  


Met Val Asn Glu Ala Leu Asp Ala Ser Val Pro Leu Lys Asp Pro Ile 
                85                  90                  95      


Lys Ile His Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg 
            100                 105                 110         


Ile Arg Pro Met Met Cys Ile Ala Ala Cys Glu Ile Val Gly Gly Asn 
        115                 120                 125             


Ile Leu Asn Ala Met Pro Ala Ala Cys Ala Val Glu Met Ile His Thr 
    130                 135                 140                 


Met Ser Leu Val His Asp Asp Leu Pro Cys Met Asp Asn Asp Asp Phe 
145                 150                 155                 160 


Arg Arg Gly Lys Pro Ile Ser His Lys Val Tyr Gly Glu Glu Met Ala 
                165                 170                 175     


Val Leu Thr Gly Asp Ala Leu Leu Ser Leu Ser Phe Glu His Ile Ala 
            180                 185                 190         


Thr Ala Thr Lys Gly Val Ser Lys Asp Arg Ile Val Arg Ala Ile Gly 
        195                 200                 205             


Glu Leu Ala Arg Ser Val Gly Ser Glu Gly Leu Val Ala Gly Gln Val 
    210                 215                 220                 


Val Asp Ile Leu Ser Glu Gly Ala Asp Val Gly Leu Asp His Leu Glu 
225                 230                 235                 240 


Tyr Ile His Ile His Lys Thr Ala Met Leu Leu Glu Ser Ser Val Val 
                245                 250                 255     


Ile Gly Ala Ile Met Gly Gly Gly Ser Asp Gln Gln Ile Glu Lys Leu 
            260                 265                 270         


Arg Lys Phe Ala Arg Ser Ile Gly Leu Leu Phe Gln Val Val Asp Asp 
        275                 280                 285             


Ile Leu Asp Val Thr Lys Ser Thr Glu Glu Leu Gly Lys Thr Ala Gly 
    290                 295                 300                 


Lys Asp Leu Leu Thr Asp Lys Thr Thr Tyr Pro Lys Leu Leu Gly Ile 
305                 310                 315                 320 


Glu Lys Ser Arg Glu Phe Ala Glu Lys Leu Asn Lys Glu Ala Gln Glu 
                325                 330                 335     


Gln Leu Ser Gly Phe Asp Arg Arg Lys Ala Ala Pro Leu Ile Ala Leu 
            340                 345                 350         


Ala Asn Tyr Asn Ala Tyr Arg Gln Asn 
        355                 360     


<210>  44
<211>  342
<212>  PRT
<213>  Fusarium fujikuroi

<400>  44

Met Ala Glu Gln Gln Ile Ser Asn Leu Leu Ser Met Phe Asp Ala Ser 
1               5                   10                  15      


His Ala Ser Gln Lys Leu Glu Ile Thr Val Gln Met Met Asp Thr Tyr 
            20                  25                  30          


His Tyr Arg Glu Thr Pro Pro Asp Ser Ser Ser Ser Glu Gly Gly Ser 
        35                  40                  45              


Leu Ser Arg Tyr Asp Glu Arg Arg Val Ser Leu Pro Leu Ser His Asn 
    50                  55                  60                  


Ala Ala Ser Pro Asp Ile Val Ser Gln Leu Cys Phe Ser Thr Ala Met 
65                  70                  75                  80  


Ser Ser Glu Leu Asn His Arg Trp Lys Ser Gln Arg Leu Lys Val Ala 
                85                  90                  95      


Asp Ser Pro Tyr Asn Tyr Ile Leu Thr Leu Pro Ser Lys Gly Ile Arg 
            100                 105                 110         


Gly Ala Phe Ile Asp Ser Leu Asn Val Trp Leu Glu Val Pro Glu Asp 
        115                 120                 125             


Glu Thr Ser Val Ile Lys Glu Val Ile Gly Met Leu His Asn Ser Ser 
    130                 135                 140                 


Leu Ile Ile Asp Asp Phe Gln Asp Asn Ser Pro Leu Arg Arg Gly Lys 
145                 150                 155                 160 


Pro Ser Thr His Thr Val Phe Gly Pro Ala Gln Ala Ile Asn Thr Ala 
                165                 170                 175     


Thr Tyr Val Ile Val Lys Ala Ile Glu Lys Ile Gln Asp Ile Val Gly 
            180                 185                 190         


His Asp Ala Leu Ala Asp Val Thr Gly Thr Ile Thr Thr Ile Phe Gln 
        195                 200                 205             


Gly Gln Ala Met Asp Leu Trp Trp Thr Ala Asn Ala Ile Val Pro Ser 
    210                 215                 220                 


Ile Gln Glu Tyr Leu Leu Met Val Asn Asp Lys Thr Gly Ala Leu Phe 
225                 230                 235                 240 


Arg Leu Ser Leu Glu Leu Leu Ala Leu Asn Ser Glu Ala Ser Ile Ser 
                245                 250                 255     


Asp Ser Ala Leu Glu Ser Leu Ser Ser Ala Val Ser Leu Leu Gly Gln 
            260                 265                 270         


Tyr Phe Gln Ile Arg Asp Asp Tyr Met Asn Leu Ile Asp Asn Lys Tyr 
        275                 280                 285             


Thr Asp Gln Lys Gly Phe Cys Glu Asp Leu Asp Glu Gly Lys Tyr Ser 
    290                 295                 300                 


Leu Thr Leu Ile His Ala Leu Gln Thr Asp Ser Ser Asp Leu Leu Thr 
305                 310                 315                 320 


Asn Ile Leu Ser Met Arg Arg Val Gln Gly Lys Leu Thr Ala Gln Lys 
                325                 330                 335     


Arg Cys Trp Phe Trp Lys 
            340         


<210>  45
<211>  300
<212>  PRT
<213>  Mus musculus

<400>  45

Met Glu Lys Thr Lys Glu Lys Ala Glu Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Arg Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Ser Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Ser Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Val Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Thr Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asp Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val Gln Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Ala Tyr Thr Arg His Thr Leu Arg Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Glu Ala Cys Gly Gly Asn Pro Ser Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Thr Glu Glu Asn Lys 
    290                 295                 300 


<210>  46
<211>  339
<212>  PRT
<213>  Thalassiosira pseudonana

<400>  46

Met Ala Arg Phe Tyr Phe Leu Asn Ala Leu Leu Met Val Ile Ser Leu 
1               5                   10                  15      


Gln Ser Thr Thr Ala Phe Thr Pro Ala Lys Leu Ala Tyr Pro Thr Thr 
            20                  25                  30          


Thr Thr Ala Leu Asn Val Ala Ser Ala Glu Thr Ser Phe Ser Leu Asp 
        35                  40                  45              


Glu Tyr Leu Ala Ser Lys Ile Gly Pro Ile Glu Ser Ala Leu Glu Ala 
    50                  55                  60                  


Ser Val Lys Ser Arg Ile Pro Gln Thr Asp Lys Ile Cys Glu Ser Met 
65                  70                  75                  80  


Ala Tyr Ser Leu Met Ala Gly Gly Lys Arg Ile Arg Pro Val Leu Cys 
                85                  90                  95      


Ile Ala Ala Cys Glu Met Phe Gly Gly Ser Gln Asp Val Ala Met Pro 
            100                 105                 110         


Thr Ala Val Ala Leu Glu Met Ile His Thr Met Ser Leu Ile His Asp 
        115                 120                 125             


Asp Leu Pro Ser Met Asp Asn Asp Asp Leu Arg Arg Gly Lys Pro Thr 
    130                 135                 140                 


Asn His Val Val Phe Gly Glu Asp Val Ala Ile Leu Ala Gly Asp Ser 
145                 150                 155                 160 


Leu Leu Ser Thr Ser Phe Glu His Val Ala Arg Glu Thr Lys Gly Val 
                165                 170                 175     


Ser Ala Glu Lys Ile Val Asp Val Ile Ala Arg Leu Gly Lys Ser Val 
            180                 185                 190         


Gly Ala Glu Gly Leu Ala Gly Gly Gln Val Met Asp Leu Glu Cys Glu 
        195                 200                 205             


Ala Lys Pro Gly Thr Thr Leu Asp Asp Leu Lys Trp Ile His Ile His 
    210                 215                 220                 


Lys Thr Ala Thr Leu Leu Gln Val Ala Val Ala Ser Gly Ala Val Leu 
225                 230                 235                 240 


Gly Gly Ala Thr Pro Glu Glu Val Ala Ala Cys Glu Leu Phe Ala Met 
                245                 250                 255     


Asn Ile Gly Leu Ala Phe Gln Val Ala Asp Asp Ile Leu Asp Val Thr 
            260                 265                 270         


Ala Ser Ser Glu Asp Leu Gly Lys Thr Ala Gly Lys Asp Glu Ala Thr 
        275                 280                 285             


Asp Lys Thr Thr Tyr Pro Lys Leu Leu Gly Leu Glu Glu Ser Lys Ala 
    290                 295                 300                 


Tyr Ala Arg Gln Leu Ile Asp Glu Ala Lys Glu Ser Leu Ala Pro Phe 
305                 310                 315                 320 


Gly Asp Arg Ala Ala Pro Leu Leu Ala Ile Ala Asp Phe Ile Ile Asp 
                325                 330                 335     


Arg Lys Asn 
            


<210>  47
<211>  355
<212>  PRT
<213>  Streptomyces clavuligerus

<400>  47

Met His Leu Ala Pro Arg Arg Val Pro Arg Gly Arg Arg Ser Pro Pro 
1               5                   10                  15      


Asp Arg Val Pro Glu Arg Gln Gly Ala Leu Gly Arg Arg Arg Gly Ala 
            20                  25                  30          


Gly Ser Thr Gly Cys Ala Arg Ala Ala Ala Gly Val His Arg Arg Arg 
        35                  40                  45              


Gly Gly Gly Glu Ala Asp Pro Ser Ala Ala Val His Arg Gly Trp Gln 
    50                  55                  60                  


Ala Gly Gly Gly Thr Gly Leu Pro Asp Glu Val Val Ser Thr Ala Ala 
65                  70                  75                  80  


Ala Leu Glu Met Phe His Ala Phe Ala Leu Ile His Asp Asp Ile Met 
                85                  90                  95      


Asp Asp Ser Ala Thr Arg Arg Gly Ser Pro Thr Val His Arg Ala Leu 
            100                 105                 110         


Ala Asp Arg Leu Gly Ala Ala Leu Asp Pro Asp Gln Ala Gly Gln Leu 
        115                 120                 125             


Gly Val Ser Thr Ala Ile Leu Val Gly Asp Leu Ala Leu Thr Trp Ser 
    130                 135                 140                 


Asp Glu Leu Leu Tyr Ala Pro Leu Thr Pro His Arg Leu Ala Ala Val 
145                 150                 155                 160 


Leu Pro Leu Val Thr Ala Met Arg Ala Glu Thr Val His Gly Gln Tyr 
                165                 170                 175     


Leu Asp Ile Thr Ser Ala Arg Arg Pro Gly Thr Asp Thr Ser Leu Ala 
            180                 185                 190         


Leu Arg Ile Ala Arg Tyr Lys Thr Ala Ala Tyr Thr Met Glu Arg Pro 
        195                 200                 205             


Leu His Ile Gly Ala Ala Leu Ala Gly Ala Arg Pro Glu Leu Leu Ala 
    210                 215                 220                 


Gly Leu Ser Ala Tyr Ala Leu Pro Ala Gly Glu Ala Phe Gln Leu Ala 
225                 230                 235                 240 


Asp Asp Leu Leu Gly Val Phe Gly Asp Pro Arg Arg Thr Gly Lys Pro 
                245                 250                 255     


Asp Leu Asp Asp Leu Arg Gly Gly Lys His Thr Val Leu Val Ala Leu 
            260                 265                 270         


Ala Arg Glu His Ala Thr Pro Glu Gln Arg His Thr Leu Asp Thr Leu 
        275                 280                 285             


Leu Gly Thr Pro Gly Leu Asp Arg Gln Gly Ala Ser Arg Leu Arg Cys 
    290                 295                 300                 


Val Leu Val Ala Thr Gly Ala Arg Ala Glu Ala Glu Arg Leu Ile Thr 
305                 310                 315                 320 


Glu Arg Arg Asp Gln Ala Leu Thr Ala Leu Asn Ala Leu Thr Leu Pro 
                325                 330                 335     


Pro Pro Leu Ala Glu Ala Leu Ala Arg Leu Thr Leu Gly Ser Thr Ala 
            340                 345                 350         


His Pro Ala 
        355 


<210>  48
<211>  330
<212>  PRT
<213>  Sulfolobus acidocaldarius

<400>  48

Met Ser Tyr Phe Asp Asn Tyr Phe Asn Glu Ile Val Asn Ser Val Asn 
1               5                   10                  15      


Asp Ile Ile Lys Ser Tyr Ile Ser Gly Asp Val Pro Lys Leu Tyr Glu 
            20                  25                  30          


Ala Ser Tyr His Leu Phe Thr Ser Gly Gly Lys Arg Leu Arg Pro Leu 
        35                  40                  45              


Ile Leu Thr Ile Ser Ser Asp Leu Phe Gly Gly Gln Arg Glu Arg Ala 
    50                  55                  60                  


Tyr Tyr Ala Gly Ala Ala Ile Glu Val Leu His Thr Phe Thr Leu Val 
65                  70                  75                  80  


His Asp Asp Ile Met Asp Gln Asp Asn Ile Arg Arg Gly Leu Pro Thr 
                85                  90                  95      


Val His Val Lys Tyr Gly Leu Pro Leu Ala Ile Leu Ala Gly Asp Leu 
            100                 105                 110         


Leu His Ala Lys Ala Phe Gln Leu Leu Thr Gln Ala Leu Arg Gly Leu 
        115                 120                 125             


Pro Ser Glu Thr Ile Ile Lys Ala Phe Asp Ile Phe Thr Arg Ser Ile 
    130                 135                 140                 


Ile Ile Ile Ser Glu Gly Gln Ala Val Asp Met Glu Phe Glu Asp Arg 
145                 150                 155                 160 


Ile Asp Ile Lys Glu Gln Glu Tyr Leu Asp Met Ile Ser Arg Lys Thr 
                165                 170                 175     


Ala Ala Leu Phe Ser Ala Ser Ser Ser Ile Gly Ala Leu Ile Ala Gly 
            180                 185                 190         


Ala Asn Asp Asn Asp Val Arg Leu Met Ser Asp Phe Gly Thr Asn Leu 
        195                 200                 205             


Gly Ile Ala Phe Gln Ile Val Asp Asp Ile Leu Gly Leu Thr Ala Asp 
    210                 215                 220                 


Glu Lys Glu Leu Gly Lys Pro Val Phe Ser Asp Ile Arg Glu Gly Lys 
225                 230                 235                 240 


Lys Thr Ile Leu Val Ile Lys Thr Leu Glu Leu Cys Lys Glu Asp Glu 
                245                 250                 255     


Lys Lys Ile Val Leu Lys Ala Leu Gly Asn Lys Ser Ala Ser Lys Glu 
            260                 265                 270         


Glu Leu Met Ser Ser Ala Asp Ile Ile Lys Lys Tyr Ser Leu Asp Tyr 
        275                 280                 285             


Ala Tyr Asn Leu Ala Glu Lys Tyr Tyr Lys Asn Ala Ile Asp Ser Leu 
    290                 295                 300                 


Asn Gln Val Ser Ser Lys Ser Asp Ile Pro Gly Lys Ala Leu Lys Tyr 
305                 310                 315                 320 


Leu Ala Glu Phe Thr Ile Arg Arg Arg Lys 
                325                 330 


<210>  49
<211>  297
<212>  PRT
<213>  Synechococcus sp.

<400>  49

Met Val Ala Gln Thr Phe Asn Leu Asp Thr Tyr Leu Ser Gln Arg Gln 
1               5                   10                  15      


Gln Gln Val Glu Glu Ala Leu Ser Ala Ala Leu Val Pro Ala Tyr Pro 
            20                  25                  30          


Glu Arg Ile Tyr Glu Ala Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys 
        35                  40                  45              


Arg Leu Arg Pro Ile Leu Cys Leu Ala Ala Cys Glu Leu Ala Gly Gly 
    50                  55                  60                  


Ser Val Glu Gln Ala Met Pro Thr Ala Cys Ala Leu Glu Met Ile His 
65                  70                  75                  80  


Thr Met Ser Leu Ile His Asp Asp Leu Pro Ala Met Asp Asn Asp Asp 
                85                  90                  95      


Phe Arg Arg Gly Lys Pro Thr Asn His Lys Val Phe Gly Glu Asp Ile 
            100                 105                 110         


Ala Ile Leu Ala Gly Asp Ala Leu Leu Ala Tyr Ala Phe Glu His Ile 
        115                 120                 125             


Ala Ser Gln Thr Arg Gly Val Pro Pro Gln Leu Val Leu Gln Val Ile 
    130                 135                 140                 


Ala Arg Ile Gly His Ala Val Ala Ala Thr Gly Leu Val Gly Gly Gln 
145                 150                 155                 160 


Val Val Asp Leu Glu Ser Glu Gly Lys Ala Ile Ser Leu Glu Thr Leu 
                165                 170                 175     


Glu Tyr Ile His Ser His Lys Thr Gly Ala Leu Leu Glu Ala Ser Val 
            180                 185                 190         


Val Ser Gly Gly Ile Leu Ala Gly Ala Asp Glu Glu Leu Leu Ala Arg 
        195                 200                 205             


Leu Ser His Tyr Ala Arg Asp Ile Gly Leu Ala Phe Gln Ile Val Asp 
    210                 215                 220                 


Asp Ile Leu Asp Val Thr Ala Thr Ser Glu Gln Leu Gly Lys Thr Ala 
225                 230                 235                 240 


Gly Lys Asp Gln Ala Ala Ala Lys Ala Thr Tyr Pro Ser Leu Leu Gly 
                245                 250                 255     


Leu Glu Ala Ser Arg Gln Lys Ala Glu Glu Leu Ile Gln Ser Ala Lys 
            260                 265                 270         


Glu Ala Leu Arg Pro Tyr Gly Ser Gln Ala Glu Pro Leu Leu Ala Leu 
        275                 280                 285             


Ala Asp Phe Ile Thr Arg Arg Gln His 
    290                 295         


<210>  50
<211>  371
<212>  PRT
<213>  Arabidopsis thaliana

<400>  50

Met Ala Ser Val Thr Leu Gly Ser Trp Ile Val Val His His His Asn 
1               5                   10                  15      


His His His Pro Ser Ser Ile Leu Thr Lys Ser Arg Ser Arg Ser Cys 
            20                  25                  30          


Pro Ile Thr Leu Thr Lys Pro Ile Ser Phe Arg Ser Lys Arg Thr Val 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Val Ser Ser Ser Val Val Thr Lys Glu Asp 
    50                  55                  60                  


Asn Leu Arg Gln Ser Glu Pro Ser Ser Phe Asp Phe Met Ser Tyr Ile 
65                  70                  75                  80  


Ile Thr Lys Ala Glu Leu Val Asn Lys Ala Leu Asp Ser Ala Val Pro 
                85                  90                  95      


Leu Arg Glu Pro Leu Lys Ile His Glu Ala Met Arg Tyr Ser Leu Leu 
            100                 105                 110         


Ala Gly Gly Lys Arg Val Arg Pro Val Leu Cys Ile Ala Ala Cys Glu 
        115                 120                 125             


Leu Val Gly Gly Glu Glu Ser Thr Ala Met Pro Ala Ala Cys Ala Val 
    130                 135                 140                 


Glu Met Ile His Thr Met Ser Leu Ile His Asp Asp Leu Pro Cys Met 
145                 150                 155                 160 


Asp Asn Asp Asp Leu Arg Arg Gly Lys Pro Thr Asn His Lys Val Phe 
                165                 170                 175     


Gly Glu Asp Val Ala Val Leu Ala Gly Asp Ala Leu Leu Ser Phe Ala 
            180                 185                 190         


Phe Glu His Leu Ala Ser Ala Thr Ser Ser Asp Val Val Ser Pro Val 
        195                 200                 205             


Arg Val Val Arg Ala Val Gly Glu Leu Ala Lys Ala Ile Gly Thr Glu 
    210                 215                 220                 


Gly Leu Val Ala Gly Gln Val Val Asp Ile Ser Ser Glu Gly Leu Asp 
225                 230                 235                 240 


Leu Asn Asp Val Gly Leu Glu His Leu Glu Phe Ile His Leu His Lys 
                245                 250                 255     


Thr Ala Ala Leu Leu Glu Ala Ser Ala Val Leu Gly Ala Ile Val Gly 
            260                 265                 270         


Gly Gly Ser Asp Asp Glu Ile Glu Arg Leu Arg Lys Phe Ala Arg Cys 
        275                 280                 285             


Ile Gly Leu Leu Phe Gln Val Val Asp Asp Ile Leu Asp Val Thr Lys 
    290                 295                 300                 


Ser Ser Lys Glu Leu Gly Lys Thr Ala Gly Lys Asp Leu Ile Ala Asp 
305                 310                 315                 320 


Lys Leu Thr Tyr Pro Lys Ile Met Gly Leu Glu Lys Ser Arg Glu Phe 
                325                 330                 335     


Ala Glu Lys Leu Asn Arg Glu Ala Arg Asp Gln Leu Leu Gly Phe Asp 
            340                 345                 350         


Ser Asp Lys Val Ala Pro Leu Leu Ala Leu Ala Asn Tyr Ile Ala Tyr 
        355                 360                 365             


Arg Gln Asn 
    370     


<210>  51
<211>  2139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleotide seqeunce encoding A. thaliana ATR2

<400>  51
atgtcttcct cttcctcttc cagtacctct atgattgatt tgatggctgc tattattaaa       60

ggtgaaccag ttatcgtctc cgacccagca aatgcctctg cttatgaatc agttgctgca      120

gaattgtctt caatgttgat cgaaaacaga caattcgcca tgatcgtaac tacatcaatc      180

gctgttttga tcggttgtat tgtcatgttg gtatggagaa gatccggtag tggtaattct      240

aaaagagtcg aacctttgaa accattagta attaagccaa gagaagaaga aatagatgac      300

ggtagaaaga aagttacaat atttttcggt acccaaactg gtacagctga aggttttgca      360

aaagccttag gtgaagaagc taaggcaaga tacgaaaaga ctagattcaa gatagtcgat      420

ttggatgact atgccgctga tgacgatgaa tacgaagaaa agttgaagaa agaagatgtt      480

gcatttttct ttttggcaac ctatggtgac ggtgaaccaa ctgacaatgc agccagattc      540

tacaaatggt ttacagaggg taatgatcgt ggtgaatggt tgaaaaactt aaagtacggt      600

gttttcggtt tgggtaacag acaatacgaa catttcaaca aagttgcaaa ggttgtcgac      660

gatattttgg tcgaacaagg tgctcaaaga ttagtccaag taggtttggg tgacgatgac      720

caatgtatag aagatgactt tactgcctgg agagaagctt tgtggcctga attagacaca      780

atcttgagag aagaaggtga caccgccgtt gctaccccat atactgctgc agtattagaa      840

tacagagttt ccatccatga tagtgaagac gcaaagttta atgatatcac tttggccaat      900

ggtaacggtt atacagtttt cgatgcacaa cacccttaca aagctaacgt tgcagtcaag      960

agagaattac atacaccaga atccgacaga agttgtatac acttggaatt tgatatcgct     1020

ggttccggtt taaccatgaa gttgggtgac catgtaggtg ttttatgcga caatttgtct     1080

gaaactgttg atgaagcatt gagattgttg gatatgtccc ctgacactta ttttagtttg     1140

cacgctgaaa aagaagatgg tacaccaatt tccagttctt taccacctcc attccctcca     1200

tgtaacttaa gaacagcctt gaccagatac gcttgcttgt tatcatcccc taaaaagtcc     1260

gccttggttg ctttagccgc tcatgctagt gatcctactg aagcagaaag attgaaacac     1320

ttagcatctc cagccggtaa agatgaatat tcaaagtggg tagttgaatc tcaaagatca     1380

ttgttagaag ttatggcaga atttccatct gccaagcctc cattaggtgt cttctttgct     1440

ggtgtagcac ctagattgca accaagattc tactcaatca gttcttcacc taagatcgct     1500

gaaactagaa ttcatgttac atgtgcatta gtctacgaaa agatgccaac cggtagaatt     1560

cacaagggtg tatgctctac ttggatgaaa aatgctgttc cttacgaaaa atcagaaaag     1620

ttgttcttag gtagaccaat cttcgtaaga caatcaaact tcaagttgcc ttctgattca     1680

aaggttccaa taatcatgat aggtcctggt acaggtttag ccccattcag aggtttcttg     1740

caagaaagat tggctttagt tgaatctggt gtcgaattag gtccttcagt tttgttcttt     1800

ggttgtagaa acagaagaat ggatttcatc tatgaagaag aattgcaaag attcgtcgaa     1860

tctggtgcat tggccgaatt atctgtagct ttttcaagag aaggtccaac taaggaatac     1920

gttcaacata agatgatgga taaggcatcc gacatatgga acatgatcag tcaaggtgct     1980

tatttgtacg tttgcggtga cgcaaagggt atggccagag atgtccatag atctttgcac     2040

acaattgctc aagaacaagg ttccatggat agtaccaaag ctgaaggttt cgtaaagaac     2100

ttacaaactt ccggtagata cttgagagat gtctggtga                            2139


<210>  52
<211>  1555
<212>  DNA
<213>  Stevia rebaudiana

<400>  52
atggcggaac aacaaaagat caagaaatca ccacacgttc tactcatccc attcccttta       60

caaggccata taaacccttt catccagttt ggcaaacgat taatctccaa aggtgtcaaa      120

acaacacttg ttaccaccat ccacacctta aactcaaccc taaaccacag taacaccacc      180

accacctcca tcgaaatcca agcaatttcc gatggttgtg atgaaggcgg ttttatgagt      240

gcaggagaat catatttgga aacattcaaa caagttgggt ctaaatcact agctgactta      300

atcaagaagc ttcaaagtga aggaaccaca attgatgcaa tcatttatga ttctatgact      360

gaatgggttt tagatgttgc aattgagttt ggaatcgatg gtggttcgtt tttcactcaa      420

gcttgtgttg taaacagctt atattatcat gttcataagg gtttgatttc tttgccattg      480

ggtgaaactg tttcggttcc tggatttcca gtgcttcaac ggtgggagac accgttaatt      540

ttgcagaatc atgagcaaat acagagccct tggtctcaga tgttgtttgg tcagtttgct      600

aatattgatc aagcacgttg ggtcttcaca aatagttttt acaagctcga ggaagaggta      660

atagagtgga cgagaaagat atggaacttg aaggtaatcg ggccaacact tccatccatg      720

taccttgaca aacgacttga tgatgataaa gataacggat ttaatctcta caaagcaaac      780

catcatgagt gcatgaactg gttagacgat aagccaaagg aatcagttgt ttacgtagca      840

tttggtagcc tggtgaaaca tggacccgaa caagtggaag aaatcacacg ggctttaata      900

gatagtgatg tcaacttctt gtgggttatc aaacataaag aagagggaaa gctcccagaa      960

aatctttcgg aagtaataaa aaccggaaag ggtttgattg tagcatggtg caaacaattg     1020

gatgtgttag cacacgaatc agtaggatgc tttgttacac attgtgggtt caactcaact     1080

cttgaagcaa taagtcttgg agtccccgtt gttgcaatgc ctcaattttc ggatcaaact     1140

acaaatgcca agcttctaga tgaaattttg ggtgttggag ttagagttaa ggctgatgag     1200

aatgggatag tgagaagagg aaatcttgcg tcatgtatta agatgattat ggaggaggaa     1260

agaggagtaa taatccgaaa gaatgcggta aaatggaagg atttggctaa agtagccgtt     1320

catgaaggtg gtagctcaga caatgatatt gtcgaatttg taagtgagct aattaaggct     1380

taaatttttg ttgctttgta ttttatgtgt tatggttttt tgatttagat gtattcaatt     1440

aatattgaat cataactaaa ttcaagatta ttgtttgtaa tattctttgt cctaaaattt     1500

tgcgacttaa aacctttagt ttataaaaag aaattagaaa atactattgc acgga          1555


<210>  53
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized S. rebaudiana UGT76G1

<400>  53
atggaaaaca agaccgaaac aacagttaga cgtaggcgta gaatcattct gtttccagta       60

ccttttcaag ggcacatcaa tccaatacta caactagcca acgttttgta ctctaaaggt      120

ttttctatta caatctttca caccaatttc aacaaaccaa aaacatccaa ttacccacat      180

ttcacattca gattcatact tgataatgat ccacaagatg aacgtatttc aaacttacct      240

acccacggtc ctttagctgg aatgagaatt ccaatcatca atgaacatgg tgccgatgag      300

cttagaagag aattagagtt acttatgttg gcatccgaag aggacgagga agtctcttgt      360

ctgattactg acgctctatg gtactttgcc caatctgtgg ctgatagttt gaatttgagg      420

agattggtac taatgacatc cagtctgttt aactttcacg ctcatgttag tttaccacaa      480

tttgacgaat tgggatactt ggaccctgat gacaagacta ggttagagga acaggcctct      540

ggttttccta tgttgaaagt caaagatatc aagtctgcct attctaattg gcaaatcttg      600

aaagagatct taggaaagat gatcaaacag acaaaggctt catctggagt gatttggaac      660

agtttcaaag agttagaaga gtctgaattg gagactgtaa tcagagaaat tccagcacct      720

tcattcctga taccattacc aaaacatttg actgcttcct cttcctcttt gttggatcat      780

gacagaacag tttttcaatg gttggaccaa caaccaccta gttctgtttt gtacgtgtca      840

tttggtagta cttctgaagt cgatgaaaag gacttccttg aaatcgcaag aggcttagtc      900

gatagtaagc agtcattcct ttgggtcgtg cgtccaggtt tcgtgaaagg ctcaacatgg      960

gtcgaaccac ttccagatgg ttttctaggc gaaagaggta gaatagtcaa atgggttcct     1020

caacaggaag ttttagctca tggcgctatt ggggcattct ggactcattc cggatggaat     1080

tcaactttag aatcagtatg cgaaggggta cctatgatct tttcagattt tggtcttgat     1140

caaccactga acgcaagata catgtctgat gttttgaaag tgggtgtata tctagaaaat     1200

ggctgggaaa ggggtgaaat agctaatgca ataagacgtg ttatggttga tgaagagggg     1260

gagtatatca gacaaaacgc aagagtgctg aagcaaaagg ccgacgtttc tctaatgaag     1320

ggaggctctt catacgaatc cttagaatct cttgtttcct acatttcatc actgtaa        1377


<210>  54
<211>  512
<212>  PRT
<213>  Lactuca sativa

<400>  54

Met Asp Gly Val Ile Asp Met Gln Thr Ile Pro Leu Arg Thr Ala Ile 
1               5                   10                  15      


Ala Ile Gly Gly Thr Ala Val Ala Leu Val Val Ala Leu Tyr Phe Trp 
            20                  25                  30          


Phe Leu Arg Ser Tyr Ala Ser Pro Ser His His Ser Asn His Leu Pro 
        35                  40                  45              


Pro Val Pro Glu Val Pro Gly Val Pro Val Leu Gly Asn Leu Leu Gln 
    50                  55                  60                  


Leu Lys Glu Lys Lys Pro Tyr Met Thr Phe Thr Lys Trp Ala Glu Met 
65                  70                  75                  80  


Tyr Gly Pro Ile Tyr Ser Ile Arg Thr Gly Ala Thr Ser Met Val Val 
                85                  90                  95      


Val Ser Ser Asn Glu Ile Ala Lys Glu Val Val Val Thr Arg Phe Pro 
            100                 105                 110         


Ser Ile Ser Thr Arg Lys Leu Ser Tyr Ala Leu Lys Val Leu Thr Glu 
        115                 120                 125             


Asp Lys Ser Met Val Ala Met Ser Asp Tyr His Asp Tyr His Lys Thr 
    130                 135                 140                 


Val Lys Arg His Ile Leu Thr Ala Val Leu Gly Pro Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Phe Arg Ala His Arg Asp Thr Met Met Glu Asn Val Ser Asn Glu 
                165                 170                 175     


Leu His Ala Phe Phe Glu Lys Asn Pro Asn Gln Glu Val Asn Leu Arg 
            180                 185                 190         


Lys Ile Phe Gln Ser Gln Leu Phe Gly Leu Ala Met Lys Gln Ala Leu 
        195                 200                 205             


Gly Lys Asp Val Glu Ser Ile Tyr Val Lys Asp Leu Glu Thr Thr Met 
    210                 215                 220                 


Lys Arg Glu Glu Ile Phe Glu Val Leu Val Val Asp Pro Met Met Gly 
225                 230                 235                 240 


Ala Ile Glu Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Lys Trp Val 
                245                 250                 255     


Pro Asn Lys Ser Phe Glu Asn Ile Ile His Arg Met Tyr Thr Arg Arg 
            260                 265                 270         


Glu Ala Val Met Lys Ala Leu Ile Gln Glu His Lys Lys Arg Ile Ala 
        275                 280                 285             


Ser Gly Glu Asn Leu Asn Ser Tyr Ile Asp Tyr Leu Leu Ser Glu Ala 
    290                 295                 300                 


Gln Thr Leu Thr Asp Lys Gln Leu Leu Met Ser Leu Trp Glu Pro Ile 
305                 310                 315                 320 


Ile Glu Ser Ser Asp Thr Thr Met Val Thr Thr Glu Trp Ala Met Tyr 
                325                 330                 335     


Glu Leu Ala Lys Asn Pro Asn Met Gln Asp Arg Leu Tyr Glu Glu Ile 
            340                 345                 350         


Gln Ser Val Cys Gly Ser Glu Lys Ile Thr Glu Glu Asn Leu Ser Gln 
        355                 360                 365             


Leu Pro Tyr Leu Tyr Ala Val Phe Gln Glu Thr Leu Arg Lys His Cys 
    370                 375                 380                 


Pro Val Pro Ile Met Pro Leu Arg Tyr Val His Glu Asn Thr Val Leu 
385                 390                 395                 400 


Gly Gly Tyr His Val Pro Ala Gly Thr Glu Val Ala Ile Asn Ile Tyr 
                405                 410                 415     


Gly Cys Asn Met Asp Lys Lys Val Trp Glu Asn Pro Glu Glu Trp Asn 
            420                 425                 430         


Pro Glu Arg Phe Leu Ser Glu Lys Glu Ser Met Asp Leu Tyr Lys Thr 
        435                 440                 445             


Met Ala Phe Gly Gly Gly Lys Arg Val Cys Ala Gly Ser Leu Gln Ala 
    450                 455                 460                 


Met Val Ile Ser Cys Ile Gly Ile Gly Arg Leu Val Gln Asp Phe Glu 
465                 470                 475                 480 


Trp Lys Leu Lys Asp Asp Ala Glu Glu Asp Val Asn Thr Leu Gly Leu 
                485                 490                 495     


Thr Thr Gln Lys Leu His Pro Leu Leu Ala Leu Ile Asn Pro Arg Lys 
            500                 505                 510         


<210>  55
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized KO

<400>  55
aagcttacta gtaaaatgga cggtgtcatc gatatgcaaa ccattccatt gagaaccgct       60

attgctattg gtggtactgc tgttgctttg gttgttgcat tatacttttg gttcttgaga      120

tcctacgctt ccccatctca tcattctaat catttgccac cagtacctga agttccaggt      180

gttccagttt tgggtaattt gttgcaattg aaagaaaaaa agccttacat gaccttcacc      240

aagtgggctg aaatgtatgg tccaatctac tctattagaa ctggtgctac ttccatggtt      300

gttgtctctt ctaacgaaat cgccaaagaa gttgttgtta ccagattccc atctatctct      360

accagaaaat tgtcttacgc cttgaaggtt ttgaccgaag ataagtctat ggttgccatg      420

tctgattatc acgattacca taagaccgtc aagagacata ttttgactgc tgttttgggt      480

ccaaacgccc aaaaaaagtt tagagcacat agagacacca tgatggaaaa cgtttccaat      540

gaattgcatg ccttcttcga aaagaaccca aatcaagaag tcaacttgag aaagatcttc      600

caatcccaat tattcggttt ggctatgaag caagccttgg gtaaagatgt tgaatccatc      660

tacgttaagg atttggaaac caccatgaag agagaagaaa tcttcgaagt tttggttgtc      720

gatccaatga tgggtgctat tgaagttgat tggagagact ttttcccata cttgaaatgg      780

gttccaaaca agtccttcga aaacatcatc catagaatgt acactagaag agaagctgtt      840

atgaaggcct tgatccaaga acacaagaaa agaattgcct ccggtgaaaa cttgaactcc      900

tacattgatt acttgttgtc tgaagcccaa accttgaccg ataagcaatt attgatgtct      960

ttgtgggaac ctattatcga atcttctgat accactatgg ttactactga atgggctatg     1020

tacgaattgg ctaagaatcc aaacatgcaa gacagattat acgaagaaat ccaatccgtt     1080

tgcggttccg aaaagattac tgaagaaaac ttgtcccaat tgccatactt gtacgctgtt     1140

ttccaagaaa ctttgagaaa gcactgtcca gttcctatta tgccattgag atatgttcac     1200

gaaaacaccg ttttgggtgg ttatcatgtt ccagctggta ctgaagttgc tattaacatc     1260

tacggttgca acatggataa gaaggtctgg gaaaatccag aagaatggaa tccagaaaga     1320

ttcttgtccg aaaaagaatc catggacttg tacaaaacta tggcttttgg tggtggtaaa     1380

agagtttgcg ctggttcttt acaagccatg gttatttctt gcattggtat cggtagattg     1440

gtccaagatt ttgaatggaa gttgaaggat gatgccgaag aagatgttaa cactttgggt     1500

ttgactaccc aaaagttgca tccattattg gccttgatta acccaagaaa gtaactcgag     1560

ccgcgg                                                                1566


<210>  56
<211>  1535
<212>  DNA
<213>  Rubus suavissimus

<400>  56
atggccaccc tccttgagca tttccaagct atgccctttg ccatccctat tgcactggct       60

gctctgtctt ggctgttcct cttttacatc aaagtttcat tcttttccaa caagagtgct      120

caggctaagc tccctcctgt gccagtggtt cctgggctgc cggtgattgg gaatttactg      180

caactcaagg agaagaaacc ctaccagact tttacaaggt gggctgagga gtatggacca      240

atctattcta tcaggactgg tgcttccacc atggtcgttc tcaataccac ccaagttgca      300

aaagaggcca tggtgaccag atatttatcc atctcaacca gaaagctatc aaacgcacta      360

aagattctta ctgctgataa atgtatggtt gcaataagtg actacaacga ttttcacaag      420

atgataaagc gatacatact ctcaaatgtt cttggaccta gtgctcagaa gcgtcaccgg      480

agcaacagag ataccttgag agctaatgtc tgcagccgat tgcattctca agtaaagaac      540

tctcctcgag aagctgtgaa tttcagaaga gtttttgagt gggaactctt tggaattgca      600

ttgaagcaag cctttggaaa ggacatagaa aagcccattt atgtggagga acttggcact      660

acactgtcaa gagatgagat ctttaaggtt ctagtgcttg acataatgga gggtgcaatt      720

gaggttgatt ggagagattt cttcccttac ctgagatgga ttccgaatac gcgcatggaa      780

acaaaaattc agcgactcta tttccgcagg aaagcagtga tgactgccct gatcaacgag      840

cagaagaagc gaattgcttc aggagaggaa atcaactgtt atatcgactt cttgcttaag      900

gaagggaaga cactgacaat ggaccaaata agtatgttgc tttgggagac ggttattgaa      960

acagcagata ctacaatggt aacgacagaa tgggctatgt atgaagttgc taaagactca     1020

aagcgtcagg atcgtctcta tcaggaaatc caaaaggttt gtggatcgga gatggttaca     1080

gaggaatact tgtcccaact gccgtacctg aatgcagttt tccatgaaac gctaaggaag     1140

cacagtccgg ctgcgttagt tcctttaaga tatgcacatg aagataccca actaggaggt     1200

tactacattc cagctggaac tgagattgct ataaacatat acgggtgtaa catggacaag     1260

catcaatggg aaagccctga ggaatggaaa ccggagagat ttttggaccc gaaatttgat     1320

cctatggatt tgtacaagac catggctttt ggggctggaa agagggtatg tgctggttct     1380

cttcaggcaa tgttaatagc gtgcccgacg attggtaggc tggtgcagga gtttgagtgg     1440

aagctgagag atggagaaga agaaaatgta gatactgttg ggctcaccac tcacaaacgc     1500

tatccaatgc atgcaatcct gaagccaaga agtta                                1535


<210>  57
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized KO

<400>  57
aagcttacta gtaaaatggc ctccatcacc catttcttac aagattttca agctactcca       60

ttcgctactg cttttgctgt tggtggtgtt tctttgttga tattcttctt cttcatccgt      120

ggtttccact ctactaagaa aaacgaatat tacaagttgc caccagttcc agttgttcca      180

ggtttgccag ttgttggtaa tttgttgcaa ttgaaagaaa agaagccata caagactttc      240

ttgagatggg ctgaaattca tggtccaatc tactctatta gaactggtgc ttctaccatg      300

gttgttgtta actctactca tgttgccaaa gaagctatgg ttaccagatt ctcttcaatc      360

tctaccagaa agttgtccaa ggctttggaa ttattgacct ccaacaaatc tatggttgcc      420

acctctgatt acaacgaatt tcacaagatg gtcaagaagt acatcttggc cgaattattg      480

ggtgctaatg ctcaaaagag acacagaatt catagagaca ccttgatcga aaacgtcttg      540

aacaaattgc atgcccatac caagaattct ccattgcaag ctgttaactt cagaaagatc      600

ttcgaatctg aattattcgg tttggctatg aagcaagcct tgggttatga tgttgattcc      660

ttgttcgttg aagaattggg tactaccttg tccagagaag aaatctacaa cgttttggtc      720

agtgacatgt tgaagggtgc tattgaagtt gattggagag actttttccc atacttgaaa      780

tggatcccaa acaagtcctt cgaaatgaag attcaaagat tggcctctag aagacaagcc      840

gttatgaact ctattgtcaa agaacaaaag aagtccattg cctctggtaa gggtgaaaac      900

tgttacttga attacttgtt gtccgaagct aagactttga ccgaaaagca aatttccatt      960

ttggcctggg aaaccattat tgaaactgct gatacaactg ttgttaccac tgaatgggct     1020

atgtacgaat tggctaaaaa cccaaagcaa caagacagat tatacaacga aatccaaaac     1080

gtctgcggta ctgataagat taccgaagaa catttgtcca agttgcctta cttgtctgct     1140

gtttttcacg aaaccttgag aaagtattct ccatctccat tggttccatt gagatacgct     1200

catgaagata ctcaattggg tggttattat gttccagccg gtactgaaat tgctgttaat     1260

atctacggtt gcaacatgga caagaatcaa tgggaaactc cagaagaatg gaagccagaa     1320

agatttttgg acgaaaagta cgatccaatg gacatgtaca agactatgtc ttttggttcc     1380

ggtaaaagag tttgcgctgg ttctttacaa gctagtttga ttgcttgtac ctccatcggt     1440

agattggttc aagaatttga atggagattg aaagacggtg aagttgaaaa cgttgatacc     1500

ttgggtttga ctacccataa gttgtatcca atgcaagcta tcttgcaacc tagaaactga     1560

ctcgagccgc gg                                                         1572


<210>  58
<211>  1512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized KO

<400>  58
atgatttcct tgttgttggg ttttgttgtc tcctccttct tgtttatctt cttcttgaaa       60

aaattgttgt tcttcttcag tcgtcacaaa atgtccgaag tttctagatt gccatctgtt      120

ccagttccag gttttccatt gattggtaac ttgttgcaat tgaaagaaaa gaagccacac      180

aagactttca ccaagtggtc tgaattatat ggtccaatct actctatcaa gatgggttcc      240

tcttctttga tcgtcttgaa ctctattgaa accgccaaag aagctatggt cagtagattc      300

tcttcaatct ctaccagaaa gttgtctaac gctttgactg ttttgacctg caacaaatct      360

atggttgcta cctctgatta cgatgacttt cataagttcg tcaagagatg cttgttgaac      420

ggtttgttgg gtgctaatgc tcaagaaaga aaaagacatt acagagatgc cttgatcgaa      480

aacgttacct ctaaattgca tgcccatacc agaaatcatc cacaagaacc agttaacttc      540

agagccattt tcgaacacga attattcggt gttgctttga aacaagcctt cggtaaagat      600

gtcgaatcca tctatgtaaa agaattgggt gtcaccttgt ccagagatga aattttcaag      660

gttttggtcc acgacatgat ggaaggtgct attgatgttg attggagaga tttcttccca      720

tacttgaaat ggatcccaaa caactctttc gaagccagaa ttcaacaaaa gcacaagaga      780

agattggctg ttatgaacgc cttgatccaa gacagattga atcaaaacga ttccgaatcc      840

gatgatgact gctacttgaa tttcttgatg tctgaagcta agaccttgac catggaacaa      900

attgctattt tggtttggga aaccattatc gaaactgctg ataccacttt ggttactact      960

gaatgggcta tgtacgaatt ggccaaacat caatctgttc aagatagatt attcaaagaa     1020

atccaatccg tctgcggtgg tgaaaagatc aaagaagaac aattgccaag attgccttac     1080

gtcaatggtg tttttcacga aaccttgaga aagtattctc cagctccatt ggttccaatt     1140

agatacgctc atgaagatac ccaaattggt ggttatcata ttccagccgg ttctgaaatt     1200

gccattaaca tctacggttg caacatggat aagaagagat gggaaagacc tgaagaatgg     1260

tggccagaaa gatttttgga agatagatac gaatcctccg acttgcataa gactatggct     1320

tttggtgctg gtaaaagagt ttgtgctggt gctttacaag ctagtttgat ggctggtatt     1380

gctatcggta gattggttca agaattcgaa tggaagttga gagatggtga agaagaaaac     1440

gttgatactt acggtttgac ctcccaaaag ttgtatccat tgatggccat tatcaaccca     1500

agaagatctt aa                                                         1512


<210>  59
<211>  1542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized KO

<400>  59
atggatgctg tgacgggttt gttaactgtc ccagcaaccg ctataactat tggtggaact       60

gctgtagcat tggcggtagc gctaatcttt tggtacctga aatcctacac atcagctaga      120

agatcccaat caaatcatct tccaagagtg cctgaagtcc caggtgttcc attgttagga      180

aatctgttac aattgaagga gaaaaagcca tacatgactt ttacgagatg ggcagcgaca      240

tatggaccta tctatagtat caaaactggg gctacaagta tggttgtggt atcatctaat      300

gagatagcca aggaggcatt ggtgaccaga ttccaatcca tatctacaag gaacttatct      360

aaagccctga aagtacttac agcagataag acaatggtcg caatgtcaga ttatgatgat      420

tatcataaaa cagttaagag acacatactg accgccgtct tgggtcctaa tgcacagaaa      480

aagcatagaa ttcacagaga tatcatgatg gataacatat ctactcaact tcatgaattc      540

gtgaaaaaca acccagaaca ggaagaggta gaccttagaa aaatctttca atctgagtta      600

ttcggcttag ctatgagaca agccttagga aaggatgttg aaagtttgta cgttgaagac      660

ctgaaaatca ctatgaatag agacgaaatc tttcaagtcc ttgttgttga tccaatgatg      720

ggagcaatcg atgttgattg gagagacttc tttccatacc taaagtgggt cccaaacaaa      780

aagttcgaaa atactattca acaaatgtac atcagaagag aagctgttat gaaatcttta      840

atcaaagagc acaaaaagag aatagcgtca ggcgaaaagc taaatagtta tatcgattac      900

cttttatctg aagctcaaac tttaaccgat cagcaactat tgatgtcctt gtgggaacca      960

atcattgaat cttcagatac aacaatggtc acaacagaat gggcaatgta cgaattagct     1020

aaaaacccta aattgcaaga taggttgtac agagacatta agtccgtctg tggatctgaa     1080

aagataaccg aagagcatct atcacagctg ccttacatta cagctatttt ccacgaaaca     1140

ctgagaagac actcaccagt tcctatcatt cctctaagac atgtacatga agataccgtt     1200

ctaggcggct accatgttcc tgctggcaca gaacttgccg ttaacatcta cggttgcaac     1260

atggacaaaa acgtttggga aaatccagag gaatggaacc cagaaagatt catgaaagag     1320

aatgagacaa ttgattttca aaagacgatg gccttcggtg gtggtaagag agtttgtgct     1380

ggttccttgc aagccctttt aactgcatct attgggattg ggagaatggt tcaagagttc     1440

gaatggaaac tgaaggatat gactcaagag gaagtgaaca cgataggcct aactacacaa     1500

atgttaagac cattgagagc tattatcaaa cctaggatct aa                        1542


<210>  60
<211>  1554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized KO

<400>  60
aagcttacta gtaaaatgga catgatgggt attgaagctg ttccatttgc tactgctgtt       60

gttttgggtg gtatttcctt ggttgttttg atcttcatca gaagattcgt ttccaacaga      120

aagagatccg ttgaaggttt gccaccagtt ccagatattc caggtttacc attgattggt      180

aacttgttgc aattgaaaga aaagaagcca cataagacct ttgctagatg ggctgaaact      240

tacggtccaa ttttctctat tagaactggt gcttctacca tgatcgtctt gaattcttct      300

gaagttgcca aagaagctat ggtcactaga ttctcttcaa tctctaccag aaagttgtcc      360

aacgccttga agattttgac cttcgataag tgtatggttg ccacctctga ttacaacgat      420

tttcacaaaa tggtcaaggg tttcatcttg agaaacgttt taggtgctcc agcccaaaaa      480

agacatagat gtcatagaga taccttgatc gaaaacatct ctaagtactt gcatgcccat      540

gttaagactt ctccattgga accagttgtc ttgaagaaga ttttcgaatc cgaaattttc      600

ggtttggctt tgaaacaagc cttgggtaag gatatcgaat ccatctatgt tgaagaattg      660

ggtactacct tgtccagaga agaaattttt gccgttttgg ttgttgatcc aatggctggt      720

gctattgaag ttgattggag agattttttc ccatacttgt cctggattcc aaacaagtct      780

atggaaatga agatccaaag aatggatttt agaagaggtg ctttgatgaa ggccttgatt      840

ggtgaacaaa agaaaagaat cggttccggt gaagaaaaga actcctacat tgatttcttg      900

ttgtctgaag ctaccacttt gaccgaaaag caaattgcta tgttgatctg ggaaaccatc      960

atcgaaattt ccgatacaac tttggttacc tctgaatggg ctatgtacga attggctaaa     1020

gacccaaata gacaagaaat cttgtacaga gaaatccaca aggtttgcgg ttctaacaag     1080

ttgactgaag aaaacttgtc caagttgcca tacttgaact ctgttttcca cgaaaccttg     1140

agaaagtatt ctccagctcc aatggttcca gttagatatg ctcatgaaga tactcaattg     1200

ggtggttacc atattccagc tggttctcaa attgccatta acatctacgg ttgcaacatg     1260

aacaaaaagc aatgggaaaa tcctgaagaa tggaagccag aaagattctt ggacgaaaag     1320

tatgacttga tggacttgca taagactatg gcttttggtg gtggtaaaag agtttgtgct     1380

ggtgctttac aagcaatgtt gattgcttgc acttccatcg gtagattcgt tcaagaattt     1440

gaatggaagt tgatgggtgg tgaagaagaa aacgttgata ctgttgcttt gacctcccaa     1500

aaattgcatc caatgcaagc cattattaag gccagagaat gactcgagcc gcgg           1554


<210>  61
<211>  2133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized CPR

<400>  61
atgcaatcag attcagtcaa agtctctcca tttgatttgg tttccgctgc tatgaatggc       60

aaggcaatgg aaaagttgaa cgctagtgaa tctgaagatc caacaacatt gcctgcacta      120

aagatgctag ttgaaaatag agaattgttg acactgttca caacttcctt cgcagttctt      180

attgggtgtc ttgtatttct aatgtggaga cgttcatcct ctaaaaagct ggtacaagat      240

ccagttccac aagttatcgt tgtaaagaag aaagagaagg agtcagaggt tgatgacggg      300

aaaaagaaag tttctatttt ctacggcaca caaacaggaa ctgccgaagg ttttgctaaa      360

gcattagtcg aggaagcaaa agtgagatat gaaaagacct ctttcaaggt tatcgatcta      420

gatgactacg ctgcagatga tgatgaatat gaggaaaaac tgaaaaagga atccttagcc      480

ttcttcttct tggccacata cggtgatggt gaacctactg ataatgctgc taacttctac      540

aagtggttca cagaaggcga cgataaaggt gaatggctga aaaagttaca atacggagta      600

tttggtttag gtaacagaca atatgaacat ttcaacaaga tcgctattgt agttgatgat      660

aaacttactg aaatgggagc caaaagatta gtaccagtag gattagggga tgatgatcag      720

tgtatagaag atgacttcac cgcctggaag gaattggtat ggccagaatt ggatcaactt      780

ttaagggacg aagatgatac ttctgtgact accccataca ctgcagccgt attggagtac      840

agagtggttt accatgataa accagcagac tcatatgctg aagatcaaac ccatacaaac      900

ggtcatgttg ttcatgatgc acagcatcct tcaagatcta atgtggcttt caaaaaggaa      960

ctacacacct ctcaatcaga taggtcttgt actcacttag aattcgatat ttctcacaca     1020

ggactgtctt acgaaactgg cgatcacgtt ggcgtttatt ccgagaactt gtccgaagtt     1080

gtcgatgaag cactaaaact gttagggtta tcaccagaca catacttctc agtccatgct     1140

gataaggagg atgggacacc tatcggtggt gcttcactac caccaccttt tcctccttgc     1200

acattgagag acgctctaac cagatacgca gatgtcttat cctcacctaa aaaggtagct     1260

ttgctggcat tggctgctca tgctagtgat cctagtgaag ccgataggtt aaagttcctg     1320

gcttcaccag ccggaaaaga tgaatatgca caatggatcg tcgccaacca acgttctttg     1380

ctagaagtga tgcaaagttt tccatctgcc aagcctccat taggtgtgtt cttcgcagca     1440

gtagctccac gtttacaacc aagatactac tctatcagtt catctcctaa gatgtctcct     1500

aacagaatac atgttacatg tgctttggtg tacgagacta ctccagcagg cagaattcac     1560

agaggattgt gttcaacctg gatgaaaaat gctgtccctt taacagagtc acctgattgc     1620

tctcaagcat ccattttcgt tagaacatca aatttcagac ttccagtgga tccaaaagtt     1680

ccagtcatta tgataggacc aggcactggt cttgccccat tcaggggctt tcttcaagag     1740

agattggcct tgaaggaatc tggtacagaa ttgggttctt ctatcttttt ctttggttgc     1800

cgtaatagaa aagttgactt tatctacgag gacgagctta acaattttgt tgagacagga     1860

gcattgtcag aattgatcgt cgcattttca agagaaggga ctgccaaaga gtacgttcag     1920

cacaagatga gtcaaaaagc ctccgatata tggaaacttc taagtgaagg tgcctatctt     1980

tatgtctgtg gcgatgcaaa gggcatggcc aaggatgtcc atagaactct gcatacaatt     2040

gttcaggaac aagggagtct ggattcttcc aaggctgaat tgtacgtcaa aaacttacag     2100

atgtctggaa gatacttaag agatgtttgg taa                                  2133


<210>  62
<211>  2106
<212>  DNA
<213>  Siraitia grosvenorii

<400>  62
atgaaggtca gtccattcga attcatgtcc gctattatca agggtagaat ggacccatct       60

aactcctcat ttgaatctac tggtgaagtt gcctccgtta tctttgaaaa cagagaattg      120

gttgccatct tgaccacttc tattgctgtt atgattggtt gcttcgttgt cttgatgtgg      180

agaagagctg gttctagaaa ggttaagaat gtcgaattgc caaagccatt gattgtccat      240

gaaccagaac ctgaagttga agatggtaag aagaaggttt ccatcttctt cggtactcaa      300

actggtactg ctgaaggttt tgctaaggct ttggctgatg aagctaaagc tagatacgaa      360

aaggctacct tcagagttgt tgatttggat gattatgctg ccgatgatga ccaatacgaa      420

gaaaaattga agaacgaatc cttcgccgtt ttcttgttgg ctacttatgg tgatggtgaa      480

cctactgata atgctgctag attttacaag tggttcgccg aaggtaaaga aagaggtgaa      540

tggttgcaaa acttgcacta tgctgttttt ggtttgggta acagacaata cgaacacttc      600

aacaagattg ctaaggttgc cgacgaatta ttggaagctc aaggtggtaa tagattggtt      660

aaggttggtt taggtgatga cgatcaatgc atcgaagatg atttttctgc ttggagagaa      720

tctttgtggc cagaattgga tatgttgttg agagatgaag atgatgctac tactgttact      780

actccatata ctgctgctgt cttggaatac agagttgtct ttcatgattc tgctgatgtt      840

gctgctgaag ataagtcttg gattaacgct aatggtcatg ctgttcatga tgctcaacat      900

ccattcagat ctaacgttgt cgtcagaaaa gaattgcata cttctgcctc tgatagatcc      960

tgttctcatt tggaattcaa catttccggt tccgctttga attacgaaac tggtgatcat     1020

gttggtgtct actgtgaaaa cttgactgaa actgttgatg aagccttgaa cttgttgggt     1080

ttgtctccag aaacttactt ctctatctac accgataacg aagatggtac tccattgggt     1140

ggttcttcat tgccaccacc atttccatca tgtactttga gaactgcttt gaccagatac     1200

gctgatttgt tgaactctcc aaaaaagtct gctttgttgg ctttagctgc tcatgcttct     1260

aatccagttg aagctgatag attgagatac ttggcttctc cagctggtaa agatgaatat     1320

gcccaatctg ttatcggttc ccaaaagtct ttgttggaag ttatggctga attcccatct     1380

gctaaaccac cattaggtgt tttttttgct gctgttgctc caagattgca acctagattc     1440

tactccattt catcctctcc aagaatggct ccatctagaa tccatgttac ttgtgctttg     1500

gtttacgata agatgccaac tggtagaatt cataagggtg tttgttctac ctggatgaag     1560

aattctgttc caatggaaaa gtcccatgaa tgttcttggg ctccaatttt cgttagacaa     1620

tccaatttta agttgccagc cgaatccaag gttccaatta tcatggttgg tccaggtact     1680

ggtttggctc cttttagagg ttttttacaa gaaagattgg ccttgaaaga atccggtgtt     1740

gaattgggtc catccatttt gtttttcggt tgcagaaaca gaagaatgga ttacatctac     1800

gaagatgaat tgaacaactt cgttgaaacc ggtgctttgt ccgaattggt tattgctttt     1860

tctagagaag gtcctaccaa agaatacgtc caacataaga tggctgaaaa ggcttctgat     1920

atctggaact tgatttctga aggtgcttac ttgtacgttt gtggtgatgc taaaggtatg     1980

gctaaggatg ttcatagaac cttgcatacc atcatgcaag aacaaggttc tttggattct     2040

tccaaagctg aatccatggt caagaacttg caaatgaatg gtagatactt aagagatgtt     2100

tggtaa                                                                2106


<210>  63
<211>  1593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized KO

<400>  63
aagcttaaaa tgagtaagtc taatagtatg aattctacat cacacgaaac cctttttcaa       60

caattggtct tgggtttgga ccgtatgcca ttgatggatg ttcactggtt gatctacgtt      120

gctttcggcg catggttatg ttcttatgtg atacatgttt tatcatcttc ctctacagta      180

aaagtgccag ttgttggata caggtctgta ttcgaaccta catggttgct tagacttaga      240

ttcgtctggg aaggtggctc tatcataggt caagggtaca ataagtttaa agactctatt      300

ttccaagtta ggaaattggg aactgatatt gtcattatac cacctaacta tattgatgaa      360

gtgagaaaat tgtcacagga caagactaga tcagttgaac ctttcattaa tgattttgca      420

ggtcaataca caagaggcat ggttttcttg caatctgact tacaaaaccg tgttatacaa      480

caaagactaa ctccaaaatt ggtttccttg accaaggtca tgaaggaaga gttggattat      540

gctttaacaa aagagatgcc tgatatgaaa aatgacgaat gggtagaagt agatatcagt      600

agtataatgg tgagattgat ttccaggatc tccgccagag tctttctagg gcctgaacac      660

tgtcgtaacc aggaatggtt gactactaca gcagaatatt cagaatcact tttcattaca      720

gggtttatct taagagttgt acctcatatc ttaagaccat tcatcgcccc tctattacct      780

tcatacagga ctctacttag aaacgtttca agtggtagaa gagtcatcgg tgacatcata      840

agatctcagc aaggggatgg taacgaagat atactttcct ggatgagaga tgctgccaca      900

ggagaggaaa agcaaatcga taacattgct cagagaatgt taattctttc tttagcatca      960

atccacacta ctgcgatgac catgacacat gccatgtacg atctatgtgc ttgccctgag     1020

tacattgaac cattaagaga tgaagttaaa tctgttgttg gggcttctgg ctgggacaag     1080

acagcgttaa acagatttca taagttggac tccttcctaa aagagtcaca aagattcaac     1140

ccagtattct tattgacatt caatagaatc taccatcaat ctatgacctt atcagatggc     1200

actaacattc catctggaac acgtattgct gttccatcac acgcaatgtt gcaagattct     1260

gcacatgtcc caggtccaac cccacctact gaatttgatg gattcagata tagtaagata     1320

cgttctgata gtaactacgc acaaaagtac ctattctcca tgaccgattc ttcaaacatg     1380

gctttcggat acggcaagta tgcttgtcca ggtagatttt acgcgtctaa tgagatgaaa     1440

ctaacattag ccattttgtt gctacaattt gagttcaaac taccagatgg taaaggtcgt     1500

cctagaaata tcactatcga ttctgatatg attccagacc caagagctag actttgcgtc     1560

agaaaaagat cacttagaga tgaatgaccg cgg                                  1593


<210>  64
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized KO

<400>  64
aagcttaaaa tggaagatcc tactgtctta tatgcttgtc ttgccattgc agttgcaact       60

ttcgttgtta gatggtacag agatccattg agatccatcc caacagttgg tggttccgat      120

ttgcctattc tatcttacat cggcgcacta agatggacaa gacgtggcag agagatactt      180

caagagggat atgatggcta cagaggatct acattcaaaa tcgcgatgtt agaccgttgg      240

atcgtgatcg caaatggtcc taaactagct gatgaagtca gacgtagacc agatgaagag      300

ttaaacttta tggacggatt aggagcattc gtccaaacta agtacacctt aggtgaagct      360

attcataacg atccatacca tgtcgatatc ataagagaaa aactaacaag aggccttcca      420

gccgtgcttc ctgatgtcat tgaagagttg acacttgcgg ttagacagta cattccaaca      480

gaaggtgatg aatgggtgtc cgtaaactgt tcaaaggccg caagagatat tgttgctaga      540

gcttctaata gagtctttgt aggtttgcct gcttgcagaa accaaggtta cttagatttg      600

gcaatagact ttacattgtc tgttgtcaag gatagagcca tcatcaatat gtttccagaa      660

ttgttgaagc caatagttgg cagagttgta ggtaacgcca ccagaaatgt tcgtagagct      720

gttccttttg ttgctccatt ggtggaggaa agacgtagac ttatggaaga gtacggtgaa      780

gactggtctg aaaaacctaa tgatatgtta cagtggataa tggatgaagc tgcatccaga      840

gatagttcag tgaaggcaat cgcagagaga ttgttaatgg tgaacttcgc ggctattcat      900

acctcatcaa acactatcac tcatgctttg taccaccttg ccgaaatgcc tgaaactttg      960

caaccactta gagaagagat cgaaccatta gtcaaagagg agggctggac caaggctgct     1020

atgggaaaaa tgtggtggtt agattcattt ctaagagaat ctcaaagata caatggcatt     1080

aacatcgtat ctttaactag aatggctgac aaagatatta cattgagtga tggcacattt     1140

ttgccaaaag gtactctagt ggccgttcca gcgtattcta ctcatagaga tgatgctgtc     1200

tacgctgatg ccttagtatt cgatcctttc agattctcac gtatgagagc gagagaaggt     1260

gaaggtacaa agcaccagtt cgttaatact tcagtcgagt acgttccatt tggtcacgga     1320

aagcatgctt gtccaggaag attcttcgcc gcaaacgaat tgaaagcaat gttggcttac     1380

attgttctaa actatgatgt aaagttgcct ggtgacggta aacgtccatt gaacatgtat     1440

tggggtccaa cagttttgcc tgcaccagca ggccaagtat tgttcagaaa gagacaagtt     1500

agtctataac cgcgg                                                      1515


<210>  65
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized KO

<400>  65
atggctacct tgttggaaca ttttcaagct atgccattcg ctattccaat tgctttggct       60

gctttgtctt ggttgttttt gttctacatc aaggtttctt tcttctccaa caaatccgct      120

caagctaaat tgccaccagt tccagttgtt ccaggtttgc cagttattgg taatttgttg      180

caattgaaag aaaagaagcc ataccaaacc ttcactagat gggctgaaga atatggtcca      240

atctactcta ttagaactgg tgcttctact atggttgtct tgaacactac tcaagttgcc      300

aaagaagcta tggttaccag atacttgtct atctctacca gaaagttgtc caacgccttg      360

aaaattttga ccgctgataa gtgcatggtt gccatttctg attacaacga tttccacaag      420

atgatcaaga gatatatctt gtctaacgtt ttgggtccat ctgcccaaaa aagacataga      480

tctaacagag ataccttgag agccaacgtt tgttctagat tgcattccca agttaagaac      540

tctccaagag aagctgtcaa ctttagaaga gttttcgaat gggaattatt cggtatcgct      600

ttgaaacaag ccttcggtaa ggatattgaa aagccaatct acgtcgaaga attgggtact      660

actttgtcca gagatgaaat cttcaaggtt ttggtcttgg acattatgga aggtgccatt      720

gaagttgatt ggagagattt tttcccatac ttgcgttgga ttccaaacac cagaatggaa      780

actaagatcc aaagattata ctttagaaga aaggccgtta tgaccgcctt gattaacgaa      840

caaaagaaaa gaattgcctc cggtgaagaa atcaactgct acatcgattt cttgttgaaa      900

gaaggtaaga ccttgaccat ggaccaaatc tctatgttgt tgtgggaaac cgttattgaa      960

actgctgata ccacaatggt tactactgaa tgggctatgt acgaagttgc taaggattct     1020

aaaagacaag acagattata ccaagaaatc caaaaggtct gcggttctga aatggttaca     1080

gaagaatact tgtcccaatt gccatacttg aatgctgttt tccacgaaac tttgagaaaa     1140

cattctccag ctgctttggt tccattgaga tatgctcatg aagatactca attgggtggt     1200

tattacattc cagccggtac tgaaattgcc attaacatct acggttgcaa catggacaaa     1260

caccaatggg aatctccaga agaatggaag ccagaaagat ttttggatcc taagtttgac     1320

ccaatggact tgtacaaaac tatggctttt ggtgctggta aaagagtttg cgctggttct     1380

ttacaagcta tgttgattgc ttgtccaacc atcggtagat tggttcaaga atttgaatgg     1440

aagttgagag atggtgaaga agaaaacgtt gatactgttg gtttgaccac ccataagaga     1500

tatccaatgc atgctatttt gaagccaaga tcttaa                               1536


<210>  66
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized CPR

<400>  66
atggcagaat tagatacact tgatatagta gtattaggtg ttatcttttt gggtactgtg       60

gcatacttta ctaagggtaa attgtggggt gttaccaagg atccatacgc taacggattc      120

gctgcaggtg gtgcttccaa gcctggcaga actagaaaca tcgtcgaagc tatggaggaa      180

tcaggtaaaa actgtgttgt tttctacggc agtcaaacag gtacagcgga ggattacgca      240

tcaagacttg caaaggaagg aaagtccaga ttcggtttga acactatgat cgccgatcta      300

gaagattatg acttcgataa cttagacact gttccatctg ataacatcgt tatgtttgta      360

ttggctactt acggtgaagg cgaaccaaca gataacgccg tggatttcta tgagttcatt      420

actggcgaag atgcctcttt caatgagggc aacgatcctc cactaggtaa cttgaattac      480

gttgcgttcg gtctgggcaa caatacctac gaacactaca actcaatggt caggaacgtt      540

aacaaggctc tagaaaagtt aggagctcat agaattggag aagcaggtga gggtgacgac      600

ggagctggaa ctatggaaga ggacttttta gcttggaaag atccaatgtg ggaagccttg      660

gctaaaaaga tgggcttgga ggaaagagaa gctgtatatg aacctatttt cgctatcaat      720

gagagagatg atttgacccc tgaagcgaat gaggtatact tgggagaacc taataagcta      780

cacttggaag gtacagcgaa aggtccattc aactcccaca acccatatat cgcaccaatt      840

gcagaatcat acgaactttt ctcagctaag gatagaaatt gtctgcatat ggaaattgat      900

atttctggta gtaatctaaa gtatgaaaca ggcgaccata tcgcgatctg gcctaccaac      960

ccaggtgaag aggtcaacaa atttcttgac attctagatc tgtctggtaa gcaacattcc     1020

gtcgtaacag tgaaagcctt agaacctaca gccaaagttc cttttccaaa tccaactacc     1080

tacgatgcta tattgagata ccatctggaa atatgcgctc cagtttctag acagtttgtc     1140

tcaactttag cagcattcgc ccctaatgat gatatcaaag ctgagatgaa ccgtttggga     1200

tcagacaaag attacttcca cgaaaagaca ggaccacatt actacaatat cgctagattt     1260

ttggcctcag tctctaaagg tgaaaaatgg acaaagatac cattttctgc tttcatagaa     1320

ggccttacaa aactacaacc aagatactat tctatctctt cctctagttt agttcagcct     1380

aaaaagatta gtattactgc tgttgtcgaa tctcagcaaa ttccaggtag agatgaccca     1440

ttcagaggtg tagcgactaa ctacttgttc gctttgaagc agaaacaaaa cggtgatcca     1500

aatccagctc cttttggcca atcatacgag ttgacaggac caaggaataa gtatgatggt     1560

atacatgttc cagtccatgt aagacattct aactttaagc taccatctga tccaggcaaa     1620

cctattatca tgatcggtcc aggtaccggt gttgcccctt ttagaggctt cgtccaagag     1680

agggcaaaac aagccagaga tggtgtagaa gttggtaaaa cactgctgtt ctttggatgt     1740

agaaagagta cagaagattt catgtatcaa aaagagtggc aagagtacaa ggaagctctt     1800

ggcgacaaat tcgaaatgat tacagctttt tcaagagaag gatctaaaaa ggtttatgtt     1860

caacacagac tgaaggaaag atcaaaggaa gtttctgatc ttctatccca aaaagcatac     1920

ttctacgttt gcggagacgc cgcacatatg gcacgtgaag tgaacactgt gttagcacag     1980

atcatagcag aaggccgtgg tgtatcagaa gccaagggtg aggaaattgt caaaaacatg     2040

agatcagcaa atcaatacca agtgtgttct gatttcgtaa ctttacactg taaagagaca     2100

acatacgcga attcagaatt gcaagaggat gtctggagtt aa                        2142


<210>  67
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized CPR

<400>  67
atggccgaat tggatacctt ggatatcgtt gttttgggtg ttatcttctt gggtactgtt       60

gcttacttca ccaaaggtaa attgtggggt gttactaagg atccatacgc taatggtttt      120

gctgctggtg gtgcttctaa accaggtaga actagaaata tcgttgaagc catggaagaa      180

tctggtaaga actgtgttgt tttctacggt tctcaaactg gtactgctga agattatgct      240

tccagattgg ctaaagaagg taagagtaga ttcggtttga acaccatgat tgccgatttg      300

gaagattacg atttcgataa cttggatacc gtcccatctg ataacatcgt tatgtttgtt      360

ttggctacct acggtgaagg tgaacctact gataatgctg ttgacttcta cgaattcatt      420

accggtgaag atgcttcttt caacgaaggt aatgatccac cattgggtaa cttgaattac      480

gttgcttttg gtttgggtaa caacacctac gaacattaca actccatggt tagaaacgtc      540

aacaaggctt tggaaaaatt gggtgctcat agaattggtg aagctggtga aggtgatgat      600

ggtgctggta ctatggaaga agattttttg gcttggaaag acccaatgtg ggaagccttg      660

gctaaaaaga tgggtttgga agaaagagaa gctgtctacg aacctatttt cgccattaac      720

gaaagagatg atttgacccc tgaagccaat gaagtttatt tgggtgaacc taacaagttg      780

cacttggaag gtactgctaa aggtccattc aattctcaca acccatatat tgctccaatc      840

gccgaatctt acgaattatt ctctgctaag gatagaaact gcttgcacat ggaaattgac      900

atctctggtt ctaatttgaa gtacgaaacc ggtgatcata ttgccatttg gccaactaat      960

ccaggtgaag aagttaacaa gttcttggac atcttggact tgtccggtaa acaacattct     1020

gttgttactg ttaaggcctt ggaacctaca gctaaagttc cttttccaaa tccaactacc     1080

tacgatgcca ttttgagata ccatttggaa atttgcgctc cagtctctag acaattcgtt     1140

tctactttgg ctgcttttgc tccaaacgat gatattaagg ctgaaatgaa cagattgggt     1200

tccgataagg attacttcca cgaaaaaact ggtccacact actacaacat tgctagattt     1260

ttggcctctg tctctaaagg tgaaaagtgg actaagattc cattctccgc tttcattgaa     1320

ggtttgacta agttgcaacc tagatattac tccatctcct cctcatcttt ggttcaacct     1380

aagaagatct ctattaccgc cgttgttgaa tcccaacaaa ttccaggtag agatgatcct     1440

tttagaggtg ttgctaccaa ttacttgttc gccttgaaac aaaagcaaaa cggtgatcca     1500

aatcctgctc catttggtca atcttatgaa ttgactggtc caagaaacaa gtacgatggt     1560

attcatgttc cagttcacgt tagacactct aactttaagt tgccatctga tccaggtaag     1620

ccaattatca tgattggtcc aggtactggt gttgctccat tcagaggttt tgttcaagaa     1680

agagctaagc aagctagaga tggtgttgaa gttggtaaaa ccttgttgtt cttcggttgt     1740

agaaagtcca ctgaagattt catgtaccaa aaagaatggc aagaatacaa agaagcctta     1800

ggtgacaagt tcgaaatgat tactgccttc tcaagagaag gttctaagaa ggtttacgtc     1860

caacacagat tgaaagaaag atccaaagaa gtctccgatt tgttgtctca aaaggcctac     1920

ttttacgttt gtggtgatgc tgctcatatg gccagagaag ttaatactgt tttggcccaa     1980

attatcgctg aaggtagagg tgtatctgaa gctaagggtg aagaaatcgt taagaacatg     2040

agatccgcca atcaatacca agtttgctct gattttgtta ccttgcactg taaagaaacc     2100

acctacgcta attccgaatt gcaagaagat gtttggtcct aa                        2142


<210>  68
<211>  500
<212>  PRT
<213>  Stevia rebaudiana

<400>  68

Met Glu Ala Ser Tyr Leu Tyr Ile Ser Ile Leu Leu Leu Leu Ala Ser 
1               5                   10                  15      


Tyr Leu Phe Thr Thr Gln Leu Arg Arg Lys Ser Ala Asn Leu Pro Pro 
            20                  25                  30          


Thr Val Phe Pro Ser Ile Pro Ile Ile Gly His Leu Tyr Leu Leu Lys 
        35                  40                  45              


Lys Pro Leu Tyr Arg Thr Leu Ala Lys Ile Ala Ala Lys Tyr Gly Pro 
    50                  55                  60                  


Ile Leu Gln Leu Gln Leu Gly Tyr Arg Arg Val Leu Val Ile Ser Ser 
65                  70                  75                  80  


Pro Ser Ala Ala Glu Glu Cys Phe Thr Asn Asn Asp Val Ile Phe Ala 
                85                  90                  95      


Asn Arg Pro Lys Thr Leu Phe Gly Lys Ile Val Gly Gly Thr Ser Leu 
            100                 105                 110         


Gly Ser Leu Ser Tyr Gly Asp Gln Trp Arg Asn Leu Arg Arg Val Ala 
        115                 120                 125             


Ser Ile Glu Ile Leu Ser Val His Arg Leu Asn Glu Phe His Asp Ile 
    130                 135                 140                 


Arg Val Asp Glu Asn Arg Leu Leu Ile Arg Lys Leu Arg Ser Ser Ser 
145                 150                 155                 160 


Ser Pro Val Thr Leu Ile Thr Val Phe Tyr Ala Leu Thr Leu Asn Val 
                165                 170                 175     


Ile Met Arg Met Ile Ser Gly Lys Arg Tyr Phe Asp Ser Gly Asp Arg 
            180                 185                 190         


Glu Leu Glu Glu Glu Gly Lys Arg Phe Arg Glu Ile Leu Asp Glu Thr 
        195                 200                 205             


Leu Leu Leu Ala Gly Ala Ser Asn Val Gly Asp Tyr Leu Pro Ile Leu 
    210                 215                 220                 


Asn Trp Leu Gly Val Lys Ser Leu Glu Lys Lys Leu Ile Ala Leu Gln 
225                 230                 235                 240 


Lys Lys Arg Asp Asp Phe Phe Gln Gly Leu Ile Glu Gln Val Arg Lys 
                245                 250                 255     


Ser Arg Gly Ala Lys Val Gly Lys Gly Arg Lys Thr Met Ile Glu Leu 
            260                 265                 270         


Leu Leu Ser Leu Gln Glu Ser Glu Pro Glu Tyr Tyr Thr Asp Ala Met 
        275                 280                 285             


Ile Arg Ser Phe Val Leu Gly Leu Leu Ala Ala Gly Ser Asp Thr Ser 
    290                 295                 300                 


Ala Gly Thr Met Glu Trp Ala Met Ser Leu Leu Val Asn His Pro His 
305                 310                 315                 320 


Val Leu Lys Lys Ala Gln Ala Glu Ile Asp Arg Val Ile Gly Asn Asn 
                325                 330                 335     


Arg Leu Ile Asp Glu Ser Asp Ile Gly Asn Ile Pro Tyr Ile Gly Cys 
            340                 345                 350         


Ile Ile Asn Glu Thr Leu Arg Leu Tyr Pro Ala Gly Pro Leu Leu Phe 
        355                 360                 365             


Pro His Glu Ser Ser Ala Asp Cys Val Ile Ser Gly Tyr Asn Ile Pro 
    370                 375                 380                 


Arg Gly Thr Met Leu Ile Val Asn Gln Trp Ala Ile His His Asp Pro 
385                 390                 395                 400 


Lys Val Trp Asp Asp Pro Glu Thr Phe Lys Pro Glu Arg Phe Gln Gly 
                405                 410                 415     


Leu Glu Gly Thr Arg Asp Gly Phe Lys Leu Met Pro Phe Gly Ser Gly 
            420                 425                 430         


Arg Arg Gly Cys Pro Gly Glu Gly Leu Ala Ile Arg Leu Leu Gly Met 
        435                 440                 445             


Thr Leu Gly Ser Val Ile Gln Cys Phe Asp Trp Glu Arg Val Gly Asp 
    450                 455                 460                 


Glu Met Val Asp Met Thr Glu Gly Leu Gly Val Thr Leu Pro Lys Ala 
465                 470                 475                 480 


Val Pro Leu Val Ala Lys Cys Lys Pro Arg Ser Glu Met Thr Asn Leu 
                485                 490                 495     


Leu Ser Glu Leu 
            500 


<210>  69
<211>  709
<212>  PRT
<213>  Stevia rebaudiana

<400>  69

Met Gln Ser Glu Ser Val Glu Ala Ser Thr Ile Asp Leu Met Thr Ala 
1               5                   10                  15      


Val Leu Lys Asp Thr Val Ile Asp Thr Ala Asn Ala Ser Asp Asn Gly 
            20                  25                  30          


Asp Ser Lys Met Pro Pro Ala Leu Ala Met Met Phe Glu Ile Arg Asp 
        35                  40                  45              


Leu Leu Leu Ile Leu Thr Thr Ser Val Ala Val Leu Val Gly Cys Phe 
    50                  55                  60                  


Val Val Leu Val Trp Lys Arg Ser Ser Gly Lys Lys Ser Gly Lys Glu 
65                  70                  75                  80  


Leu Glu Pro Pro Lys Ile Val Val Pro Lys Arg Arg Leu Glu Gln Glu 
                85                  90                  95      


Val Asp Asp Gly Lys Lys Lys Val Thr Ile Phe Phe Gly Thr Gln Thr 
            100                 105                 110         


Gly Thr Ala Glu Gly Phe Ala Lys Ala Leu Phe Glu Glu Ala Lys Ala 
        115                 120                 125             


Arg Tyr Glu Lys Ala Ala Phe Lys Val Ile Asp Leu Asp Asp Tyr Ala 
    130                 135                 140                 


Ala Asp Leu Asp Glu Tyr Ala Glu Lys Leu Lys Lys Glu Thr Tyr Ala 
145                 150                 155                 160 


Phe Phe Phe Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala 
                165                 170                 175     


Ala Lys Phe Tyr Lys Trp Phe Thr Glu Gly Asp Glu Lys Gly Val Trp 
            180                 185                 190         


Leu Gln Lys Leu Gln Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln Tyr 
        195                 200                 205             


Glu His Phe Asn Lys Ile Gly Ile Val Val Asp Asp Gly Leu Thr Glu 
    210                 215                 220                 


Gln Gly Ala Lys Arg Ile Val Pro Val Gly Leu Gly Asp Asp Asp Gln 
225                 230                 235                 240 


Ser Ile Glu Asp Asp Phe Ser Ala Trp Lys Glu Leu Val Trp Pro Glu 
                245                 250                 255     


Leu Asp Leu Leu Leu Arg Asp Glu Asp Asp Lys Ala Ala Ala Thr Pro 
            260                 265                 270         


Tyr Thr Ala Ala Ile Pro Glu Tyr Arg Val Val Phe His Asp Lys Pro 
        275                 280                 285             


Asp Ala Phe Ser Asp Asp His Thr Gln Thr Asn Gly His Ala Val His 
    290                 295                 300                 


Asp Ala Gln His Pro Cys Arg Ser Asn Val Ala Val Lys Lys Glu Leu 
305                 310                 315                 320 


His Thr Pro Glu Ser Asp Arg Ser Cys Thr His Leu Glu Phe Asp Ile 
                325                 330                 335     


Ser His Thr Gly Leu Ser Tyr Glu Thr Gly Asp His Val Gly Val Tyr 
            340                 345                 350         


Cys Glu Asn Leu Ile Glu Val Val Glu Glu Ala Gly Lys Leu Leu Gly 
        355                 360                 365             


Leu Ser Thr Asp Thr Tyr Phe Ser Leu His Ile Asp Asn Glu Asp Gly 
    370                 375                 380                 


Ser Pro Leu Gly Gly Pro Ser Leu Gln Pro Pro Phe Pro Pro Cys Thr 
385                 390                 395                 400 


Leu Arg Lys Ala Leu Thr Asn Tyr Ala Asp Leu Leu Ser Ser Pro Lys 
                405                 410                 415     


Lys Ser Thr Leu Leu Ala Leu Ala Ala His Ala Ser Asp Pro Thr Glu 
            420                 425                 430         


Ala Asp Arg Leu Arg Phe Leu Ala Ser Arg Glu Gly Lys Asp Glu Tyr 
        435                 440                 445             


Ala Glu Trp Val Val Ala Asn Gln Arg Ser Leu Leu Glu Val Met Glu 
    450                 455                 460                 


Ala Phe Pro Ser Ala Arg Pro Pro Leu Gly Val Phe Phe Ala Ala Val 
465                 470                 475                 480 


Ala Pro Arg Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Lys 
                485                 490                 495     


Met Glu Pro Asn Arg Ile His Val Thr Cys Ala Leu Val Tyr Glu Lys 
            500                 505                 510         


Thr Pro Ala Gly Arg Ile His Lys Gly Ile Cys Ser Thr Trp Met Lys 
        515                 520                 525             


Asn Ala Val Pro Leu Thr Glu Ser Gln Asp Cys Ser Trp Ala Pro Ile 
    530                 535                 540                 


Phe Val Arg Thr Ser Asn Phe Arg Leu Pro Ile Asp Pro Lys Val Pro 
545                 550                 555                 560 


Val Ile Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe 
                565                 570                 575     


Leu Gln Glu Arg Leu Ala Leu Lys Glu Ser Gly Thr Glu Leu Gly Ser 
            580                 585                 590         


Ser Ile Leu Phe Phe Gly Cys Arg Asn Arg Lys Val Asp Tyr Ile Tyr 
        595                 600                 605             


Glu Asn Glu Leu Asn Asn Phe Val Glu Asn Gly Ala Leu Ser Glu Leu 
    610                 615                 620                 


Asp Val Ala Phe Ser Arg Asp Gly Pro Thr Lys Glu Tyr Val Gln His 
625                 630                 635                 640 


Lys Met Thr Gln Lys Ala Ser Glu Ile Trp Asn Met Leu Ser Glu Gly 
                645                 650                 655     


Ala Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Lys Asp Val 
            660                 665                 670         


His Arg Thr Leu His Thr Ile Val Gln Glu Gln Gly Ser Leu Asp Ser 
        675                 680                 685             


Ser Lys Ala Glu Leu Tyr Val Lys Asn Leu Gln Met Ser Gly Arg Tyr 
    690                 695                 700                 


Leu Arg Asp Val Trp 
705                 


<210>  70
<211>  514
<212>  PRT
<213>  Castanea mollissima

<400>  70

Met Ala Ser Ile Thr His Phe Leu Gln Asp Phe Gln Ala Thr Pro Phe 
1               5                   10                  15      


Ala Thr Ala Phe Ala Val Gly Gly Val Ser Leu Leu Ile Phe Phe Phe 
            20                  25                  30          


Phe Ile Arg Gly Phe His Ser Thr Lys Lys Asn Glu Tyr Tyr Lys Leu 
        35                  40                  45              


Pro Pro Val Pro Val Val Pro Gly Leu Pro Val Val Gly Asn Leu Leu 
    50                  55                  60                  


Gln Leu Lys Glu Lys Lys Pro Tyr Lys Thr Phe Leu Arg Trp Ala Glu 
65                  70                  75                  80  


Ile His Gly Pro Ile Tyr Ser Ile Arg Thr Gly Ala Ser Thr Met Val 
                85                  90                  95      


Val Val Asn Ser Thr His Val Ala Lys Glu Ala Met Val Thr Arg Phe 
            100                 105                 110         


Ser Ser Ile Ser Thr Arg Lys Leu Ser Lys Ala Leu Glu Leu Leu Thr 
        115                 120                 125             


Ser Asn Lys Ser Met Val Ala Thr Ser Asp Tyr Asn Glu Phe His Lys 
    130                 135                 140                 


Met Val Lys Lys Tyr Ile Leu Ala Glu Leu Leu Gly Ala Asn Ala Gln 
145                 150                 155                 160 


Lys Arg His Arg Ile His Arg Asp Thr Leu Ile Glu Asn Val Leu Asn 
                165                 170                 175     


Lys Leu His Ala His Thr Lys Asn Ser Pro Leu Gln Ala Val Asn Phe 
            180                 185                 190         


Arg Lys Ile Phe Glu Ser Glu Leu Phe Gly Leu Ala Met Lys Gln Ala 
        195                 200                 205             


Leu Gly Tyr Asp Val Asp Ser Leu Phe Val Glu Glu Leu Gly Thr Thr 
    210                 215                 220                 


Leu Ser Arg Glu Glu Ile Tyr Asn Val Leu Val Ser Asp Met Leu Lys 
225                 230                 235                 240 


Gly Ala Ile Glu Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Lys Trp 
                245                 250                 255     


Ile Pro Asn Lys Ser Phe Glu Met Lys Ile Gln Arg Leu Ala Ser Arg 
            260                 265                 270         


Arg Gln Ala Val Met Asn Ser Ile Val Lys Glu Gln Lys Lys Ser Ile 
        275                 280                 285             


Ala Ser Gly Lys Gly Glu Asn Cys Tyr Leu Asn Tyr Leu Leu Ser Glu 
    290                 295                 300                 


Ala Lys Thr Leu Thr Glu Lys Gln Ile Ser Ile Leu Ala Trp Glu Thr 
305                 310                 315                 320 


Ile Ile Glu Thr Ala Asp Thr Thr Val Val Thr Thr Glu Trp Ala Met 
                325                 330                 335     


Tyr Glu Leu Ala Lys Asn Pro Lys Gln Gln Asp Arg Leu Tyr Asn Glu 
            340                 345                 350         


Ile Gln Asn Val Cys Gly Thr Asp Lys Ile Thr Glu Glu His Leu Ser 
        355                 360                 365             


Lys Leu Pro Tyr Leu Ser Ala Val Phe His Glu Thr Leu Arg Lys Tyr 
    370                 375                 380                 


Ser Pro Ser Pro Leu Val Pro Leu Arg Tyr Ala His Glu Asp Thr Gln 
385                 390                 395                 400 


Leu Gly Gly Tyr Tyr Val Pro Ala Gly Thr Glu Ile Ala Val Asn Ile 
                405                 410                 415     


Tyr Gly Cys Asn Met Asp Lys Asn Gln Trp Glu Thr Pro Glu Glu Trp 
            420                 425                 430         


Lys Pro Glu Arg Phe Leu Asp Glu Lys Tyr Asp Pro Met Asp Met Tyr 
        435                 440                 445             


Lys Thr Met Ser Phe Gly Ser Gly Lys Arg Val Cys Ala Gly Ser Leu 
    450                 455                 460                 


Gln Ala Ser Leu Ile Ala Cys Thr Ser Ile Gly Arg Leu Val Gln Glu 
465                 470                 475                 480 


Phe Glu Trp Arg Leu Lys Asp Gly Glu Val Glu Asn Val Asp Thr Leu 
                485                 490                 495     


Gly Leu Thr Thr His Lys Leu Tyr Pro Met Gln Ala Ile Leu Gln Pro 
            500                 505                 510         


Arg Asn 
        


<210>  71
<211>  506
<212>  PRT
<213>  Eutrema halophilum

<400>  71

Met Ala Ser Met Ile Ser Leu Leu Leu Gly Phe Val Val Ser Ser Phe 
1               5                   10                  15      


Leu Phe Ile Phe Phe Leu Lys Lys Leu Leu Phe Phe Phe Ser Arg His 
            20                  25                  30          


Lys Met Ser Glu Val Ser Arg Leu Pro Ser Val Pro Val Pro Gly Phe 
        35                  40                  45              


Pro Leu Ile Gly Asn Leu Leu Gln Leu Lys Glu Lys Lys Pro His Lys 
    50                  55                  60                  


Thr Phe Thr Lys Trp Ser Glu Leu Tyr Gly Pro Ile Tyr Ser Ile Lys 
65                  70                  75                  80  


Met Gly Ser Ser Ser Leu Ile Val Leu Asn Ser Ile Glu Thr Ala Lys 
                85                  90                  95      


Glu Ala Met Val Ser Arg Phe Ser Ser Ile Ser Thr Arg Lys Leu Ser 
            100                 105                 110         


Asn Ala Leu Thr Val Leu Thr Cys Asn Lys Ser Met Val Ala Thr Ser 
        115                 120                 125             


Asp Tyr Asp Asp Phe His Lys Phe Val Lys Arg Cys Leu Leu Asn Gly 
    130                 135                 140                 


Leu Leu Gly Ala Asn Ala Gln Glu Arg Lys Arg His Tyr Arg Asp Ala 
145                 150                 155                 160 


Leu Ile Glu Asn Val Thr Ser Lys Leu His Ala His Thr Arg Asn His 
                165                 170                 175     


Pro Gln Glu Pro Val Asn Phe Arg Ala Ile Phe Glu His Glu Leu Phe 
            180                 185                 190         


Gly Val Ala Leu Lys Gln Ala Phe Gly Lys Asp Val Glu Ser Ile Tyr 
        195                 200                 205             


Val Lys Glu Leu Gly Val Thr Leu Ser Arg Asp Glu Ile Phe Lys Val 
    210                 215                 220                 


Leu Val His Asp Met Met Glu Gly Ala Ile Asp Val Asp Trp Arg Asp 
225                 230                 235                 240 


Phe Phe Pro Tyr Leu Lys Trp Ile Pro Asn Asn Ser Phe Glu Ala Arg 
                245                 250                 255     


Ile Gln Gln Lys His Lys Arg Arg Leu Ala Val Met Asn Ala Leu Ile 
            260                 265                 270         


Gln Asp Arg Leu Asn Gln Asn Asp Ser Glu Ser Asp Asp Asp Cys Tyr 
        275                 280                 285             


Leu Asn Phe Leu Met Ser Glu Ala Lys Thr Leu Thr Met Glu Gln Ile 
    290                 295                 300                 


Ala Ile Leu Val Trp Glu Thr Ile Ile Glu Thr Ala Asp Thr Thr Leu 
305                 310                 315                 320 


Val Thr Thr Glu Trp Ala Met Tyr Glu Leu Ala Lys His Gln Ser Val 
                325                 330                 335     


Gln Asp Arg Leu Phe Lys Glu Ile Gln Ser Val Cys Gly Gly Glu Lys 
            340                 345                 350         


Ile Lys Glu Glu Gln Leu Pro Arg Leu Pro Tyr Val Asn Gly Val Phe 
        355                 360                 365             


His Glu Thr Leu Arg Lys Tyr Ser Pro Ala Pro Leu Val Pro Ile Arg 
    370                 375                 380                 


Tyr Ala His Glu Asp Thr Gln Ile Gly Gly Tyr His Ile Pro Ala Gly 
385                 390                 395                 400 


Ser Glu Ile Ala Ile Asn Ile Tyr Gly Cys Asn Met Asp Lys Lys Arg 
                405                 410                 415     


Trp Glu Arg Pro Glu Glu Trp Trp Pro Glu Arg Phe Leu Glu Asp Arg 
            420                 425                 430         


Tyr Glu Ser Ser Asp Leu His Lys Thr Met Ala Phe Gly Ala Gly Lys 
        435                 440                 445             


Arg Val Cys Ala Gly Ala Leu Gln Ala Ser Leu Met Ala Gly Ile Ala 
    450                 455                 460                 


Ile Gly Arg Leu Val Gln Glu Phe Glu Trp Lys Leu Arg Asp Gly Glu 
465                 470                 475                 480 


Glu Glu Asn Val Asp Thr Tyr Gly Leu Thr Ser Gln Lys Leu Tyr Pro 
                485                 490                 495     


Leu Met Ala Ile Ile Asn Pro Arg Arg Ser 
            500                 505     


<210>  72
<211>  508
<212>  PRT
<213>  Vitis vinifera

<400>  72

Met Asp Met Met Gly Ile Glu Ala Val Pro Phe Ala Thr Ala Val Val 
1               5                   10                  15      


Leu Gly Gly Ile Ser Leu Val Val Leu Ile Phe Ile Arg Arg Phe Val 
            20                  25                  30          


Ser Asn Arg Lys Arg Ser Val Glu Gly Leu Pro Pro Val Pro Asp Ile 
        35                  40                  45              


Pro Gly Leu Pro Leu Ile Gly Asn Leu Leu Gln Leu Lys Glu Lys Lys 
    50                  55                  60                  


Pro His Lys Thr Phe Ala Arg Trp Ala Glu Thr Tyr Gly Pro Ile Phe 
65                  70                  75                  80  


Ser Ile Arg Thr Gly Ala Ser Thr Met Ile Val Leu Asn Ser Ser Glu 
                85                  90                  95      


Val Ala Lys Glu Ala Met Val Thr Arg Phe Ser Ser Ile Ser Thr Arg 
            100                 105                 110         


Lys Leu Ser Asn Ala Leu Lys Ile Leu Thr Phe Asp Lys Cys Met Val 
        115                 120                 125             


Ala Thr Ser Asp Tyr Asn Asp Phe His Lys Met Val Lys Gly Phe Ile 
    130                 135                 140                 


Leu Arg Asn Val Leu Gly Ala Pro Ala Gln Lys Arg His Arg Cys His 
145                 150                 155                 160 


Arg Asp Thr Leu Ile Glu Asn Ile Ser Lys Tyr Leu His Ala His Val 
                165                 170                 175     


Lys Thr Ser Pro Leu Glu Pro Val Val Leu Lys Lys Ile Phe Glu Ser 
            180                 185                 190         


Glu Ile Phe Gly Leu Ala Leu Lys Gln Ala Leu Gly Lys Asp Ile Glu 
        195                 200                 205             


Ser Ile Tyr Val Glu Glu Leu Gly Thr Thr Leu Ser Arg Glu Glu Ile 
    210                 215                 220                 


Phe Ala Val Leu Val Val Asp Pro Met Ala Gly Ala Ile Glu Val Asp 
225                 230                 235                 240 


Trp Arg Asp Phe Phe Pro Tyr Leu Ser Trp Ile Pro Asn Lys Ser Met 
                245                 250                 255     


Glu Met Lys Ile Gln Arg Met Asp Phe Arg Arg Gly Ala Leu Met Lys 
            260                 265                 270         


Ala Leu Ile Gly Glu Gln Lys Lys Arg Ile Gly Ser Gly Glu Glu Lys 
        275                 280                 285             


Asn Ser Tyr Ile Asp Phe Leu Leu Ser Glu Ala Thr Thr Leu Thr Glu 
    290                 295                 300                 


Lys Gln Ile Ala Met Leu Ile Trp Glu Thr Ile Ile Glu Ile Ser Asp 
305                 310                 315                 320 


Thr Thr Leu Val Thr Ser Glu Trp Ala Met Tyr Glu Leu Ala Lys Asp 
                325                 330                 335     


Pro Asn Arg Gln Glu Ile Leu Tyr Arg Glu Ile His Lys Val Cys Gly 
            340                 345                 350         


Ser Asn Lys Leu Thr Glu Glu Asn Leu Ser Lys Leu Pro Tyr Leu Asn 
        355                 360                 365             


Ser Val Phe His Glu Thr Leu Arg Lys Tyr Ser Pro Ala Pro Met Val 
    370                 375                 380                 


Pro Val Arg Tyr Ala His Glu Asp Thr Gln Leu Gly Gly Tyr His Ile 
385                 390                 395                 400 


Pro Ala Gly Ser Gln Ile Ala Ile Asn Ile Tyr Gly Cys Asn Met Asn 
                405                 410                 415     


Lys Lys Gln Trp Glu Asn Pro Glu Glu Trp Lys Pro Glu Arg Phe Leu 
            420                 425                 430         


Asp Glu Lys Tyr Asp Leu Met Asp Leu His Lys Thr Met Ala Phe Gly 
        435                 440                 445             


Gly Gly Lys Arg Val Cys Ala Gly Ala Leu Gln Ala Met Leu Ile Ala 
    450                 455                 460                 


Cys Thr Ser Ile Gly Arg Phe Val Gln Glu Phe Glu Trp Lys Leu Met 
465                 470                 475                 480 


Gly Gly Glu Glu Glu Asn Val Asp Thr Val Ala Leu Thr Ser Gln Lys 
                485                 490                 495     


Leu His Pro Met Gln Ala Ile Ile Lys Ala Arg Glu 
            500                 505             


<210>  73
<211>  713
<212>  PRT
<213>  Fusarium fujikuroi

<400>  73

Met Ala Glu Leu Asp Thr Leu Asp Ile Val Val Leu Gly Val Ile Phe 
1               5                   10                  15      


Leu Gly Thr Val Ala Tyr Phe Thr Lys Gly Lys Leu Trp Gly Val Thr 
            20                  25                  30          


Lys Asp Pro Tyr Ala Asn Gly Phe Ala Ala Gly Gly Ala Ser Lys Pro 
        35                  40                  45              


Gly Arg Thr Arg Asn Ile Val Glu Ala Met Glu Glu Ser Gly Lys Asn 
    50                  55                  60                  


Cys Val Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Asp Tyr Ala 
65                  70                  75                  80  


Ser Arg Leu Ala Lys Glu Gly Lys Ser Arg Phe Gly Leu Asn Thr Met 
                85                  90                  95      


Ile Ala Asp Leu Glu Asp Tyr Asp Phe Asp Asn Leu Asp Thr Val Pro 
            100                 105                 110         


Ser Asp Asn Ile Val Met Phe Val Leu Ala Thr Tyr Gly Glu Gly Glu 
        115                 120                 125             


Pro Thr Asp Asn Ala Val Asp Phe Tyr Glu Phe Ile Thr Gly Glu Asp 
    130                 135                 140                 


Ala Ser Phe Asn Glu Gly Asn Asp Pro Pro Leu Gly Asn Leu Asn Tyr 
145                 150                 155                 160 


Val Ala Phe Gly Leu Gly Asn Asn Thr Tyr Glu His Tyr Asn Ser Met 
                165                 170                 175     


Val Arg Asn Val Asn Lys Ala Leu Glu Lys Leu Gly Ala His Arg Ile 
            180                 185                 190         


Gly Glu Ala Gly Glu Gly Asp Asp Gly Ala Gly Thr Met Glu Glu Asp 
        195                 200                 205             


Phe Leu Ala Trp Lys Asp Pro Met Trp Glu Ala Leu Ala Lys Lys Met 
    210                 215                 220                 


Gly Leu Glu Glu Arg Glu Ala Val Tyr Glu Pro Ile Phe Ala Ile Asn 
225                 230                 235                 240 


Glu Arg Asp Asp Leu Thr Pro Glu Ala Asn Glu Val Tyr Leu Gly Glu 
                245                 250                 255     


Pro Asn Lys Leu His Leu Glu Gly Thr Ala Lys Gly Pro Phe Asn Ser 
            260                 265                 270         


His Asn Pro Tyr Ile Ala Pro Ile Ala Glu Ser Tyr Glu Leu Phe Ser 
        275                 280                 285             


Ala Lys Asp Arg Asn Cys Leu His Met Glu Ile Asp Ile Ser Gly Ser 
    290                 295                 300                 


Asn Leu Lys Tyr Glu Thr Gly Asp His Ile Ala Ile Trp Pro Thr Asn 
305                 310                 315                 320 


Pro Gly Glu Glu Val Asn Lys Phe Leu Asp Ile Leu Asp Leu Ser Gly 
                325                 330                 335     


Lys Gln His Ser Val Val Thr Val Lys Ala Leu Glu Pro Thr Ala Lys 
            340                 345                 350         


Val Pro Phe Pro Asn Pro Thr Thr Tyr Asp Ala Ile Leu Arg Tyr His 
        355                 360                 365             


Leu Glu Ile Cys Ala Pro Val Ser Arg Gln Phe Val Ser Thr Leu Ala 
    370                 375                 380                 


Ala Phe Ala Pro Asn Asp Asp Ile Lys Ala Glu Met Asn Arg Leu Gly 
385                 390                 395                 400 


Ser Asp Lys Asp Tyr Phe His Glu Lys Thr Gly Pro His Tyr Tyr Asn 
                405                 410                 415     


Ile Ala Arg Phe Leu Ala Ser Val Ser Lys Gly Glu Lys Trp Thr Lys 
            420                 425                 430         


Ile Pro Phe Ser Ala Phe Ile Glu Gly Leu Thr Lys Leu Gln Pro Arg 
        435                 440                 445             


Tyr Tyr Ser Ile Ser Ser Ser Ser Leu Val Gln Pro Lys Lys Ile Ser 
    450                 455                 460                 


Ile Thr Ala Val Val Glu Ser Gln Gln Ile Pro Gly Arg Asp Asp Pro 
465                 470                 475                 480 


Phe Arg Gly Val Ala Thr Asn Tyr Leu Phe Ala Leu Lys Gln Lys Gln 
                485                 490                 495     


Asn Gly Asp Pro Asn Pro Ala Pro Phe Gly Gln Ser Tyr Glu Leu Thr 
            500                 505                 510         


Gly Pro Arg Asn Lys Tyr Asp Gly Ile His Val Pro Val His Val Arg 
        515                 520                 525             


His Ser Asn Phe Lys Leu Pro Ser Asp Pro Gly Lys Pro Ile Ile Met 
    530                 535                 540                 


Ile Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly Phe Val Gln Glu 
545                 550                 555                 560 


Arg Ala Lys Gln Ala Arg Asp Gly Val Glu Val Gly Lys Thr Leu Leu 
                565                 570                 575     


Phe Phe Gly Cys Arg Lys Ser Thr Glu Asp Phe Met Tyr Gln Lys Glu 
            580                 585                 590         


Trp Gln Glu Tyr Lys Glu Ala Leu Gly Asp Lys Phe Glu Met Ile Thr 
        595                 600                 605             


Ala Phe Ser Arg Glu Gly Ser Lys Lys Val Tyr Val Gln His Arg Leu 
    610                 615                 620                 


Lys Glu Arg Ser Lys Glu Val Ser Asp Leu Leu Ser Gln Lys Ala Tyr 
625                 630                 635                 640 


Phe Tyr Val Cys Gly Asp Ala Ala His Met Ala Arg Glu Val Asn Thr 
                645                 650                 655     


Val Leu Ala Gln Ile Ile Ala Glu Gly Arg Gly Val Ser Glu Ala Lys 
            660                 665                 670         


Gly Glu Glu Ile Val Lys Asn Met Arg Ser Ala Asn Gln Tyr Gln Val 
        675                 680                 685             


Cys Ser Asp Phe Val Thr Leu His Cys Lys Glu Thr Thr Tyr Ala Asn 
    690                 695                 700                 


Ser Glu Leu Gln Glu Asp Val Trp Ser 
705                 710             


<210>  74
<211>  701
<212>  PRT
<213>  Siraitia grosvenorii

<400>  74

Met Lys Val Ser Pro Phe Glu Phe Met Ser Ala Ile Ile Lys Gly Arg 
1               5                   10                  15      


Met Asp Pro Ser Asn Ser Ser Phe Glu Ser Thr Gly Glu Val Ala Ser 
            20                  25                  30          


Val Ile Phe Glu Asn Arg Glu Leu Val Ala Ile Leu Thr Thr Ser Ile 
        35                  40                  45              


Ala Val Met Ile Gly Cys Phe Val Val Leu Met Trp Arg Arg Ala Gly 
    50                  55                  60                  


Ser Arg Lys Val Lys Asn Val Glu Leu Pro Lys Pro Leu Ile Val His 
65                  70                  75                  80  


Glu Pro Glu Pro Glu Val Glu Asp Gly Lys Lys Lys Val Ser Ile Phe 
                85                  90                  95      


Phe Gly Thr Gln Thr Gly Thr Ala Glu Gly Phe Ala Lys Ala Leu Ala 
            100                 105                 110         


Asp Glu Ala Lys Ala Arg Tyr Glu Lys Ala Thr Phe Arg Val Val Asp 
        115                 120                 125             


Leu Asp Asp Tyr Ala Ala Asp Asp Asp Gln Tyr Glu Glu Lys Leu Lys 
    130                 135                 140                 


Asn Glu Ser Phe Ala Val Phe Leu Leu Ala Thr Tyr Gly Asp Gly Glu 
145                 150                 155                 160 


Pro Thr Asp Asn Ala Ala Arg Phe Tyr Lys Trp Phe Ala Glu Gly Lys 
                165                 170                 175     


Glu Arg Gly Glu Trp Leu Gln Asn Leu His Tyr Ala Val Phe Gly Leu 
            180                 185                 190         


Gly Asn Arg Gln Tyr Glu His Phe Asn Lys Ile Ala Lys Val Ala Asp 
        195                 200                 205             


Glu Leu Leu Glu Ala Gln Gly Gly Asn Arg Leu Val Lys Val Gly Leu 
    210                 215                 220                 


Gly Asp Asp Asp Gln Cys Ile Glu Asp Asp Phe Ser Ala Trp Arg Glu 
225                 230                 235                 240 


Ser Leu Trp Pro Glu Leu Asp Met Leu Leu Arg Asp Glu Asp Asp Ala 
                245                 250                 255     


Thr Thr Val Thr Thr Pro Tyr Thr Ala Ala Val Leu Glu Tyr Arg Val 
            260                 265                 270         


Val Phe His Asp Ser Ala Asp Val Ala Ala Glu Asp Lys Ser Trp Ile 
        275                 280                 285             


Asn Ala Asn Gly His Ala Val His Asp Ala Gln His Pro Phe Arg Ser 
    290                 295                 300                 


Asn Val Val Val Arg Lys Glu Leu His Thr Ser Ala Ser Asp Arg Ser 
305                 310                 315                 320 


Cys Ser His Leu Glu Phe Asn Ile Ser Gly Ser Ala Leu Asn Tyr Glu 
                325                 330                 335     


Thr Gly Asp His Val Gly Val Tyr Cys Glu Asn Leu Thr Glu Thr Val 
            340                 345                 350         


Asp Glu Ala Leu Asn Leu Leu Gly Leu Ser Pro Glu Thr Tyr Phe Ser 
        355                 360                 365             


Ile Tyr Thr Asp Asn Glu Asp Gly Thr Pro Leu Gly Gly Ser Ser Leu 
    370                 375                 380                 


Pro Pro Pro Phe Pro Ser Cys Thr Leu Arg Thr Ala Leu Thr Arg Tyr 
385                 390                 395                 400 


Ala Asp Leu Leu Asn Ser Pro Lys Lys Ser Ala Leu Leu Ala Leu Ala 
                405                 410                 415     


Ala His Ala Ser Asn Pro Val Glu Ala Asp Arg Leu Arg Tyr Leu Ala 
            420                 425                 430         


Ser Pro Ala Gly Lys Asp Glu Tyr Ala Gln Ser Val Ile Gly Ser Gln 
        435                 440                 445             


Lys Ser Leu Leu Glu Val Met Ala Glu Phe Pro Ser Ala Lys Pro Pro 
    450                 455                 460                 


Leu Gly Val Phe Phe Ala Ala Val Ala Pro Arg Leu Gln Pro Arg Phe 
465                 470                 475                 480 


Tyr Ser Ile Ser Ser Ser Pro Arg Met Ala Pro Ser Arg Ile His Val 
                485                 490                 495     


Thr Cys Ala Leu Val Tyr Asp Lys Met Pro Thr Gly Arg Ile His Lys 
            500                 505                 510         


Gly Val Cys Ser Thr Trp Met Lys Asn Ser Val Pro Met Glu Lys Ser 
        515                 520                 525             


His Glu Cys Ser Trp Ala Pro Ile Phe Val Arg Gln Ser Asn Phe Lys 
    530                 535                 540                 


Leu Pro Ala Glu Ser Lys Val Pro Ile Ile Met Val Gly Pro Gly Thr 
545                 550                 555                 560 


Gly Leu Ala Pro Phe Arg Gly Phe Leu Gln Glu Arg Leu Ala Leu Lys 
                565                 570                 575     


Glu Ser Gly Val Glu Leu Gly Pro Ser Ile Leu Phe Phe Gly Cys Arg 
            580                 585                 590         


Asn Arg Arg Met Asp Tyr Ile Tyr Glu Asp Glu Leu Asn Asn Phe Val 
        595                 600                 605             


Glu Thr Gly Ala Leu Ser Glu Leu Val Ile Ala Phe Ser Arg Glu Gly 
    610                 615                 620                 


Pro Thr Lys Glu Tyr Val Gln His Lys Met Ala Glu Lys Ala Ser Asp 
625                 630                 635                 640 


Ile Trp Asn Leu Ile Ser Glu Gly Ala Tyr Leu Tyr Val Cys Gly Asp 
                645                 650                 655     


Ala Lys Gly Met Ala Lys Asp Val His Arg Thr Leu His Thr Ile Met 
            660                 665                 670         


Gln Glu Gln Gly Ser Leu Asp Ser Ser Lys Ala Glu Ser Met Val Lys 
        675                 680                 685             


Asn Leu Gln Met Asn Gly Arg Tyr Leu Arg Asp Val Trp 
    690                 695                 700     


<210>  75
<211>  511
<212>  PRT
<213>  Rubus suavissimus

<400>  75

Met Ala Thr Leu Leu Glu His Phe Gln Ala Met Pro Phe Ala Ile Pro 
1               5                   10                  15      


Ile Ala Leu Ala Ala Leu Ser Trp Leu Phe Leu Phe Tyr Ile Lys Val 
            20                  25                  30          


Ser Phe Phe Ser Asn Lys Ser Ala Gln Ala Lys Leu Pro Pro Val Pro 
        35                  40                  45              


Val Val Pro Gly Leu Pro Val Ile Gly Asn Leu Leu Gln Leu Lys Glu 
    50                  55                  60                  


Lys Lys Pro Tyr Gln Thr Phe Thr Arg Trp Ala Glu Glu Tyr Gly Pro 
65                  70                  75                  80  


Ile Tyr Ser Ile Arg Thr Gly Ala Ser Thr Met Val Val Leu Asn Thr 
                85                  90                  95      


Thr Gln Val Ala Lys Glu Ala Met Val Thr Arg Tyr Leu Ser Ile Ser 
            100                 105                 110         


Thr Arg Lys Leu Ser Asn Ala Leu Lys Ile Leu Thr Ala Asp Lys Cys 
        115                 120                 125             


Met Val Ala Ile Ser Asp Tyr Asn Asp Phe His Lys Met Ile Lys Arg 
    130                 135                 140                 


Tyr Ile Leu Ser Asn Val Leu Gly Pro Ser Ala Gln Lys Arg His Arg 
145                 150                 155                 160 


Ser Asn Arg Asp Thr Leu Arg Ala Asn Val Cys Ser Arg Leu His Ser 
                165                 170                 175     


Gln Val Lys Asn Ser Pro Arg Glu Ala Val Asn Phe Arg Arg Val Phe 
            180                 185                 190         


Glu Trp Glu Leu Phe Gly Ile Ala Leu Lys Gln Ala Phe Gly Lys Asp 
        195                 200                 205             


Ile Glu Lys Pro Ile Tyr Val Glu Glu Leu Gly Thr Thr Leu Ser Arg 
    210                 215                 220                 


Asp Glu Ile Phe Lys Val Leu Val Leu Asp Ile Met Glu Gly Ala Ile 
225                 230                 235                 240 


Glu Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Arg Trp Ile Pro Asn 
                245                 250                 255     


Thr Arg Met Glu Thr Lys Ile Gln Arg Leu Tyr Phe Arg Arg Lys Ala 
            260                 265                 270         


Val Met Thr Ala Leu Ile Asn Glu Gln Lys Lys Arg Ile Ala Ser Gly 
        275                 280                 285             


Glu Glu Ile Asn Cys Tyr Ile Asp Phe Leu Leu Lys Glu Gly Lys Thr 
    290                 295                 300                 


Leu Thr Met Asp Gln Ile Ser Met Leu Leu Trp Glu Thr Val Ile Glu 
305                 310                 315                 320 


Thr Ala Asp Thr Thr Met Val Thr Thr Glu Trp Ala Met Tyr Glu Val 
                325                 330                 335     


Ala Lys Asp Ser Lys Arg Gln Asp Arg Leu Tyr Gln Glu Ile Gln Lys 
            340                 345                 350         


Val Cys Gly Ser Glu Met Val Thr Glu Glu Tyr Leu Ser Gln Leu Pro 
        355                 360                 365             


Tyr Leu Asn Ala Val Phe His Glu Thr Leu Arg Lys His Ser Pro Ala 
    370                 375                 380                 


Ala Leu Val Pro Leu Arg Tyr Ala His Glu Asp Thr Gln Leu Gly Gly 
385                 390                 395                 400 


Tyr Tyr Ile Pro Ala Gly Thr Glu Ile Ala Ile Asn Ile Tyr Gly Cys 
                405                 410                 415     


Asn Met Asp Lys His Gln Trp Glu Ser Pro Glu Glu Trp Lys Pro Glu 
            420                 425                 430         


Arg Phe Leu Asp Pro Lys Phe Asp Pro Met Asp Leu Tyr Lys Thr Met 
        435                 440                 445             


Ala Phe Gly Ala Gly Lys Arg Val Cys Ala Gly Ser Leu Gln Ala Met 
    450                 455                 460                 


Leu Ile Ala Cys Pro Thr Ile Gly Arg Leu Val Gln Glu Phe Glu Trp 
465                 470                 475                 480 


Lys Leu Arg Asp Gly Glu Glu Glu Asn Val Asp Thr Val Gly Leu Thr 
                485                 490                 495     


Thr His Lys Arg Tyr Pro Met His Ala Ile Leu Lys Pro Arg Ser 
            500                 505                 510     


<210>  76
<211>  710
<212>  PRT
<213>  Stevia rebaudiana

<400>  76

Met Gln Ser Asp Ser Val Lys Val Ser Pro Phe Asp Leu Val Ser Ala 
1               5                   10                  15      


Ala Met Asn Gly Lys Ala Met Glu Lys Leu Asn Ala Ser Glu Ser Glu 
            20                  25                  30          


Asp Pro Thr Thr Leu Pro Ala Leu Lys Met Leu Val Glu Asn Arg Glu 
        35                  40                  45              


Leu Leu Thr Leu Phe Thr Thr Ser Phe Ala Val Leu Ile Gly Cys Leu 
    50                  55                  60                  


Val Phe Leu Met Trp Arg Arg Ser Ser Ser Lys Lys Leu Val Gln Asp 
65                  70                  75                  80  


Pro Val Pro Gln Val Ile Val Val Lys Lys Lys Glu Lys Glu Ser Glu 
                85                  90                  95      


Val Asp Asp Gly Lys Lys Lys Val Ser Ile Phe Tyr Gly Thr Gln Thr 
            100                 105                 110         


Gly Thr Ala Glu Gly Phe Ala Lys Ala Leu Val Glu Glu Ala Lys Val 
        115                 120                 125             


Arg Tyr Glu Lys Thr Ser Phe Lys Val Ile Asp Leu Asp Asp Tyr Ala 
    130                 135                 140                 


Ala Asp Asp Asp Glu Tyr Glu Glu Lys Leu Lys Lys Glu Ser Leu Ala 
145                 150                 155                 160 


Phe Phe Phe Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala 
                165                 170                 175     


Ala Asn Phe Tyr Lys Trp Phe Thr Glu Gly Asp Asp Lys Gly Glu Trp 
            180                 185                 190         


Leu Lys Lys Leu Gln Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln Tyr 
        195                 200                 205             


Glu His Phe Asn Lys Ile Ala Ile Val Val Asp Asp Lys Leu Thr Glu 
    210                 215                 220                 


Met Gly Ala Lys Arg Leu Val Pro Val Gly Leu Gly Asp Asp Asp Gln 
225                 230                 235                 240 


Cys Ile Glu Asp Asp Phe Thr Ala Trp Lys Glu Leu Val Trp Pro Glu 
                245                 250                 255     


Leu Asp Gln Leu Leu Arg Asp Glu Asp Asp Thr Ser Val Thr Thr Pro 
            260                 265                 270         


Tyr Thr Ala Ala Val Leu Glu Tyr Arg Val Val Tyr His Asp Lys Pro 
        275                 280                 285             


Ala Asp Ser Tyr Ala Glu Asp Gln Thr His Thr Asn Gly His Val Val 
    290                 295                 300                 


His Asp Ala Gln His Pro Ser Arg Ser Asn Val Ala Phe Lys Lys Glu 
305                 310                 315                 320 


Leu His Thr Ser Gln Ser Asp Arg Ser Cys Thr His Leu Glu Phe Asp 
                325                 330                 335     


Ile Ser His Thr Gly Leu Ser Tyr Glu Thr Gly Asp His Val Gly Val 
            340                 345                 350         


Tyr Ser Glu Asn Leu Ser Glu Val Val Asp Glu Ala Leu Lys Leu Leu 
        355                 360                 365             


Gly Leu Ser Pro Asp Thr Tyr Phe Ser Val His Ala Asp Lys Glu Asp 
    370                 375                 380                 


Gly Thr Pro Ile Gly Gly Ala Ser Leu Pro Pro Pro Phe Pro Pro Cys 
385                 390                 395                 400 


Thr Leu Arg Asp Ala Leu Thr Arg Tyr Ala Asp Val Leu Ser Ser Pro 
                405                 410                 415     


Lys Lys Val Ala Leu Leu Ala Leu Ala Ala His Ala Ser Asp Pro Ser 
            420                 425                 430         


Glu Ala Asp Arg Leu Lys Phe Leu Ala Ser Pro Ala Gly Lys Asp Glu 
        435                 440                 445             


Tyr Ala Gln Trp Ile Val Ala Asn Gln Arg Ser Leu Leu Glu Val Met 
    450                 455                 460                 


Gln Ser Phe Pro Ser Ala Lys Pro Pro Leu Gly Val Phe Phe Ala Ala 
465                 470                 475                 480 


Val Ala Pro Arg Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro 
                485                 490                 495     


Lys Met Ser Pro Asn Arg Ile His Val Thr Cys Ala Leu Val Tyr Glu 
            500                 505                 510         


Thr Thr Pro Ala Gly Arg Ile His Arg Gly Leu Cys Ser Thr Trp Met 
        515                 520                 525             


Lys Asn Ala Val Pro Leu Thr Glu Ser Pro Asp Cys Ser Gln Ala Ser 
    530                 535                 540                 


Ile Phe Val Arg Thr Ser Asn Phe Arg Leu Pro Val Asp Pro Lys Val 
545                 550                 555                 560 


Pro Val Ile Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly 
                565                 570                 575     


Phe Leu Gln Glu Arg Leu Ala Leu Lys Glu Ser Gly Thr Glu Leu Gly 
            580                 585                 590         


Ser Ser Ile Phe Phe Phe Gly Cys Arg Asn Arg Lys Val Asp Phe Ile 
        595                 600                 605             


Tyr Glu Asp Glu Leu Asn Asn Phe Val Glu Thr Gly Ala Leu Ser Glu 
    610                 615                 620                 


Leu Ile Val Ala Phe Ser Arg Glu Gly Thr Ala Lys Glu Tyr Val Gln 
625                 630                 635                 640 


His Lys Met Ser Gln Lys Ala Ser Asp Ile Trp Lys Leu Leu Ser Glu 
                645                 650                 655     


Gly Ala Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Lys Asp 
            660                 665                 670         


Val His Arg Thr Leu His Thr Ile Val Gln Glu Gln Gly Ser Leu Asp 
        675                 680                 685             


Ser Ser Lys Ala Glu Leu Tyr Val Lys Asn Leu Gln Met Ser Gly Arg 
    690                 695                 700                 


Tyr Leu Arg Asp Val Trp 
705                 710 


<210>  77
<211>  525
<212>  PRT
<213>  Fusarium fujikuroi

<400>  77

Met Ser Lys Ser Asn Ser Met Asn Ser Thr Ser His Glu Thr Leu Phe 
1               5                   10                  15      


Gln Gln Leu Val Leu Gly Leu Asp Arg Met Pro Leu Met Asp Val His 
            20                  25                  30          


Trp Leu Ile Tyr Val Ala Phe Gly Ala Trp Leu Cys Ser Tyr Val Ile 
        35                  40                  45              


His Val Leu Ser Ser Ser Ser Thr Val Lys Val Pro Val Val Gly Tyr 
    50                  55                  60                  


Arg Ser Val Phe Glu Pro Thr Trp Leu Leu Arg Leu Arg Phe Val Trp 
65                  70                  75                  80  


Glu Gly Gly Ser Ile Ile Gly Gln Gly Tyr Asn Lys Phe Lys Asp Ser 
                85                  90                  95      


Ile Phe Gln Val Arg Lys Leu Gly Thr Asp Ile Val Ile Ile Pro Pro 
            100                 105                 110         


Asn Tyr Ile Asp Glu Val Arg Lys Leu Ser Gln Asp Lys Thr Arg Ser 
        115                 120                 125             


Val Glu Pro Phe Ile Asn Asp Phe Ala Gly Gln Tyr Thr Arg Gly Met 
    130                 135                 140                 


Val Phe Leu Gln Ser Asp Leu Gln Asn Arg Val Ile Gln Gln Arg Leu 
145                 150                 155                 160 


Thr Pro Lys Leu Val Ser Leu Thr Lys Val Met Lys Glu Glu Leu Asp 
                165                 170                 175     


Tyr Ala Leu Thr Lys Glu Met Pro Asp Met Lys Asn Asp Glu Trp Val 
            180                 185                 190         


Glu Val Asp Ile Ser Ser Ile Met Val Arg Leu Ile Ser Arg Ile Ser 
        195                 200                 205             


Ala Arg Val Phe Leu Gly Pro Glu His Cys Arg Asn Gln Glu Trp Leu 
    210                 215                 220                 


Thr Thr Thr Ala Glu Tyr Ser Glu Ser Leu Phe Ile Thr Gly Phe Ile 
225                 230                 235                 240 


Leu Arg Val Val Pro His Ile Leu Arg Pro Phe Ile Ala Pro Leu Leu 
                245                 250                 255     


Pro Ser Tyr Arg Thr Leu Leu Arg Asn Val Ser Ser Gly Arg Arg Val 
            260                 265                 270         


Ile Gly Asp Ile Ile Arg Ser Gln Gln Gly Asp Gly Asn Glu Asp Ile 
        275                 280                 285             


Leu Ser Trp Met Arg Asp Ala Ala Thr Gly Glu Glu Lys Gln Ile Asp 
    290                 295                 300                 


Asn Ile Ala Gln Arg Met Leu Ile Leu Ser Leu Ala Ser Ile His Thr 
305                 310                 315                 320 


Thr Ala Met Thr Met Thr His Ala Met Tyr Asp Leu Cys Ala Cys Pro 
                325                 330                 335     


Glu Tyr Ile Glu Pro Leu Arg Asp Glu Val Lys Ser Val Val Gly Ala 
            340                 345                 350         


Ser Gly Trp Asp Lys Thr Ala Leu Asn Arg Phe His Lys Leu Asp Ser 
        355                 360                 365             


Phe Leu Lys Glu Ser Gln Arg Phe Asn Pro Val Phe Leu Leu Thr Phe 
    370                 375                 380                 


Asn Arg Ile Tyr His Gln Ser Met Thr Leu Ser Asp Gly Thr Asn Ile 
385                 390                 395                 400 


Pro Ser Gly Thr Arg Ile Ala Val Pro Ser His Ala Met Leu Gln Asp 
                405                 410                 415     


Ser Ala His Val Pro Gly Pro Thr Pro Pro Thr Glu Phe Asp Gly Phe 
            420                 425                 430         


Arg Tyr Ser Lys Ile Arg Ser Asp Ser Asn Tyr Ala Gln Lys Tyr Leu 
        435                 440                 445             


Phe Ser Met Thr Asp Ser Ser Asn Met Ala Phe Gly Tyr Gly Lys Tyr 
    450                 455                 460                 


Ala Cys Pro Gly Arg Phe Tyr Ala Ser Asn Glu Met Lys Leu Thr Leu 
465                 470                 475                 480 


Ala Ile Leu Leu Leu Gln Phe Glu Phe Lys Leu Pro Asp Gly Lys Gly 
                485                 490                 495     


Arg Pro Arg Asn Ile Thr Ile Asp Ser Asp Met Ile Pro Asp Pro Arg 
            500                 505                 510         


Ala Arg Leu Cys Val Arg Lys Arg Ser Leu Arg Asp Glu 
        515                 520                 525 


<210>  78
<211>  499
<212>  PRT
<213>  Trametes versicolor

<400>  78

Met Glu Asp Pro Thr Val Leu Tyr Ala Cys Leu Ala Ile Ala Val Ala 
1               5                   10                  15      


Thr Phe Val Val Arg Trp Tyr Arg Asp Pro Leu Arg Ser Ile Pro Thr 
            20                  25                  30          


Val Gly Gly Ser Asp Leu Pro Ile Leu Ser Tyr Ile Gly Ala Leu Arg 
        35                  40                  45              


Trp Thr Arg Arg Gly Arg Glu Ile Leu Gln Glu Gly Tyr Asp Gly Tyr 
    50                  55                  60                  


Arg Gly Ser Thr Phe Lys Ile Ala Met Leu Asp Arg Trp Ile Val Ile 
65                  70                  75                  80  


Ala Asn Gly Pro Lys Leu Ala Asp Glu Val Arg Arg Arg Pro Asp Glu 
                85                  90                  95      


Glu Leu Asn Phe Met Asp Gly Leu Gly Ala Phe Val Gln Thr Lys Tyr 
            100                 105                 110         


Thr Leu Gly Glu Ala Ile His Asn Asp Pro Tyr His Val Asp Ile Ile 
        115                 120                 125             


Arg Glu Lys Leu Thr Arg Gly Leu Pro Ala Val Leu Pro Asp Val Ile 
    130                 135                 140                 


Glu Glu Leu Thr Leu Ala Val Arg Gln Tyr Ile Pro Thr Glu Gly Asp 
145                 150                 155                 160 


Glu Trp Val Ser Val Asn Cys Ser Lys Ala Ala Arg Asp Ile Val Ala 
                165                 170                 175     


Arg Ala Ser Asn Arg Val Phe Val Gly Leu Pro Ala Cys Arg Asn Gln 
            180                 185                 190         


Gly Tyr Leu Asp Leu Ala Ile Asp Phe Thr Leu Ser Val Val Lys Asp 
        195                 200                 205             


Arg Ala Ile Ile Asn Met Phe Pro Glu Leu Leu Lys Pro Ile Val Gly 
    210                 215                 220                 


Arg Val Val Gly Asn Ala Thr Arg Asn Val Arg Arg Ala Val Pro Phe 
225                 230                 235                 240 


Val Ala Pro Leu Val Glu Glu Arg Arg Arg Leu Met Glu Glu Tyr Gly 
                245                 250                 255     


Glu Asp Trp Ser Glu Lys Pro Asn Asp Met Leu Gln Trp Ile Met Asp 
            260                 265                 270         


Glu Ala Ala Ser Arg Asp Ser Ser Val Lys Ala Ile Ala Glu Arg Leu 
        275                 280                 285             


Leu Met Val Asn Phe Ala Ala Ile His Thr Ser Ser Asn Thr Ile Thr 
    290                 295                 300                 


His Ala Leu Tyr His Leu Ala Glu Met Pro Glu Thr Leu Gln Pro Leu 
305                 310                 315                 320 


Arg Glu Glu Ile Glu Pro Leu Val Lys Glu Glu Gly Trp Thr Lys Ala 
                325                 330                 335     


Ala Met Gly Lys Met Trp Trp Leu Asp Ser Phe Leu Arg Glu Ser Gln 
            340                 345                 350         


Arg Tyr Asn Gly Ile Asn Ile Val Ser Leu Thr Arg Met Ala Asp Lys 
        355                 360                 365             


Asp Ile Thr Leu Ser Asp Gly Thr Phe Leu Pro Lys Gly Thr Leu Val 
    370                 375                 380                 


Ala Val Pro Ala Tyr Ser Thr His Arg Asp Asp Ala Val Tyr Ala Asp 
385                 390                 395                 400 


Ala Leu Val Phe Asp Pro Phe Arg Phe Ser Arg Met Arg Ala Arg Glu 
                405                 410                 415     


Gly Glu Gly Thr Lys His Gln Phe Val Asn Thr Ser Val Glu Tyr Val 
            420                 425                 430         


Pro Phe Gly His Gly Lys His Ala Cys Pro Gly Arg Phe Phe Ala Ala 
        435                 440                 445             


Asn Glu Leu Lys Ala Met Leu Ala Tyr Ile Val Leu Asn Tyr Asp Val 
    450                 455                 460                 


Lys Leu Pro Gly Asp Gly Lys Arg Pro Leu Asn Met Tyr Trp Gly Pro 
465                 470                 475                 480 


Thr Val Leu Pro Ala Pro Ala Gly Gln Val Leu Phe Arg Lys Arg Gln 
                485                 490                 495     


Val Ser Leu 
            


<210>  79
<211>  513
<212>  PRT
<213>  Stevia rebaudiana

<400>  79

Met Asp Ala Val Thr Gly Leu Leu Thr Val Pro Ala Thr Ala Ile Thr 
1               5                   10                  15      


Ile Gly Gly Thr Ala Val Ala Leu Ala Val Ala Leu Ile Phe Trp Tyr 
            20                  25                  30          


Leu Lys Ser Tyr Thr Ser Ala Arg Arg Ser Gln Ser Asn His Leu Pro 
        35                  40                  45              


Arg Val Pro Glu Val Pro Gly Val Pro Leu Leu Gly Asn Leu Leu Gln 
    50                  55                  60                  


Leu Lys Glu Lys Lys Pro Tyr Met Thr Phe Thr Arg Trp Ala Ala Thr 
65                  70                  75                  80  


Tyr Gly Pro Ile Tyr Ser Ile Lys Thr Gly Ala Thr Ser Met Val Val 
                85                  90                  95      


Val Ser Ser Asn Glu Ile Ala Lys Glu Ala Leu Val Thr Arg Phe Gln 
            100                 105                 110         


Ser Ile Ser Thr Arg Asn Leu Ser Lys Ala Leu Lys Val Leu Thr Ala 
        115                 120                 125             


Asp Lys Thr Met Val Ala Met Ser Asp Tyr Asp Asp Tyr His Lys Thr 
    130                 135                 140                 


Val Lys Arg His Ile Leu Thr Ala Val Leu Gly Pro Asn Ala Gln Lys 
145                 150                 155                 160 


Lys His Arg Ile His Arg Asp Ile Met Met Asp Asn Ile Ser Thr Gln 
                165                 170                 175     


Leu His Glu Phe Val Lys Asn Asn Pro Glu Gln Glu Glu Val Asp Leu 
            180                 185                 190         


Arg Lys Ile Phe Gln Ser Glu Leu Phe Gly Leu Ala Met Arg Gln Ala 
        195                 200                 205             


Leu Gly Lys Asp Val Glu Ser Leu Tyr Val Glu Asp Leu Lys Ile Thr 
    210                 215                 220                 


Met Asn Arg Asp Glu Ile Phe Gln Val Leu Val Val Asp Pro Met Met 
225                 230                 235                 240 


Gly Ala Ile Asp Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Lys Trp 
                245                 250                 255     


Val Pro Asn Lys Lys Phe Glu Asn Thr Ile Gln Gln Met Tyr Ile Arg 
            260                 265                 270         


Arg Glu Ala Val Met Lys Ser Leu Ile Lys Glu His Lys Lys Arg Ile 
        275                 280                 285             


Ala Ser Gly Glu Lys Leu Asn Ser Tyr Ile Asp Tyr Leu Leu Ser Glu 
    290                 295                 300                 


Ala Gln Thr Leu Thr Asp Gln Gln Leu Leu Met Ser Leu Trp Glu Pro 
305                 310                 315                 320 


Ile Ile Glu Ser Ser Asp Thr Thr Met Val Thr Thr Glu Trp Ala Met 
                325                 330                 335     


Tyr Glu Leu Ala Lys Asn Pro Lys Leu Gln Asp Arg Leu Tyr Arg Asp 
            340                 345                 350         


Ile Lys Ser Val Cys Gly Ser Glu Lys Ile Thr Glu Glu His Leu Ser 
        355                 360                 365             


Gln Leu Pro Tyr Ile Thr Ala Ile Phe His Glu Thr Leu Arg Arg His 
    370                 375                 380                 


Ser Pro Val Pro Ile Ile Pro Leu Arg His Val His Glu Asp Thr Val 
385                 390                 395                 400 


Leu Gly Gly Tyr His Val Pro Ala Gly Thr Glu Leu Ala Val Asn Ile 
                405                 410                 415     


Tyr Gly Cys Asn Met Asp Lys Asn Val Trp Glu Asn Pro Glu Glu Trp 
            420                 425                 430         


Asn Pro Glu Arg Phe Met Lys Glu Asn Glu Thr Ile Asp Phe Gln Lys 
        435                 440                 445             


Thr Met Ala Phe Gly Gly Gly Lys Arg Val Cys Ala Gly Ser Leu Gln 
    450                 455                 460                 


Ala Leu Leu Thr Ala Ser Ile Gly Ile Gly Arg Met Val Gln Glu Phe 
465                 470                 475                 480 


Glu Trp Lys Leu Lys Asp Met Thr Gln Glu Glu Val Asn Thr Ile Gly 
                485                 490                 495     


Leu Thr Thr Gln Met Leu Arg Pro Leu Arg Ala Ile Ile Lys Pro Arg 
            500                 505                 510         


Ile 
    


<210>  80
<211>  1572
<212>  DNA
<213>  Rubus suavissimus

<400>  80
atggaagtaa cagtagctag tagtgtagcc ctgagcctgg tctttattag catagtagta       60

agatgggcat ggagtgtggt gaattgggtg tggtttaagc cgaagaagct ggaaagattt      120

ttgagggagc aaggccttaa aggcaattcc tacaggtttt tatatggaga catgaaggag      180

aactctatcc tgctcaaaca agcaagatcc aaacccatga acctctccac ctcccatgac      240

atagcacctc aagtcacccc ttttgtcgac caaaccgtga aagcttacgg taagaactct      300

tttaattggg ttggccccat accaagggtg aacataatga atccagaaga tttgaaggac      360

gtcttaacaa aaaatgttga ctttgttaag ccaatatcaa acccacttat caagttgcta      420

gctacaggta ttgcaatcta tgaaggtgag aaatggacta aacacagaag gattatcaac      480

ccaacattcc attcggagag gctaaagcgt atgttacctt catttcacca aagttgtaat      540

gagatggtca aggaatggga gagcttggtg tcaaaagagg gttcatcatg tgagttggat      600

gtctggcctt ttcttgaaaa tatgtcggca gatgtgatct cgagaacagc atttggaact      660

agctacaaaa aaggacagaa aatctttgaa ctcttgagag agcaagtaat atatgtaacg      720

aaaggctttc aaagttttta cattccagga tggaggtttc tcccaactaa gatgaacaag      780

aggatgaatg agattaacga agaaataaaa ggattaatca ggggtattat aattgacaga      840

gagcaaatca ttaaggcagg tgaagaaacc aacgatgact tattaggtgc acttatggag      900

tcaaacttga aggacattcg ggaacatggg aaaaacaaca aaaatgttgg gatgagtatt      960

gaagatgtaa ttcaggagtg taagctgttt tactttgctg ggcaagaaac cacttcagtg     1020

ttgctggctt ggacaatggt tttacttggt caaaatcaga actggcaaga tcgagcaaga     1080

caagaggttt tgcaagtctt tggaagcagc aagccagatt ttgatggtct agctcacctt     1140

aaagtcgtaa ccatgatttt gcttgaagtt cttcgattat acccaccagt cattgaactt     1200

attcgaacca ttcacaagaa aacacaactt gggaagctct cactaccaga aggagttgaa     1260

gtccgcttac caacactgct cattcaccat gacaaggaac tgtggggtga tgatgcaaac     1320

cagttcaatc cagagaggtt ttcggaagga gtttccaaag caacaaagaa ccgactctca     1380

ttcttcccct tcggagccgg tccacgcatt tgcattggac agaacttttc tatgatggaa     1440

gcaaagttgg ccttagcatt gatcttgcaa cacttcacct ttgagctttc tccatctcat     1500

gcacatgctc cttcccatcg tataaccctt caaccacagt atggtgttcg tatcatttta     1560

catcgacgtt ag                                                         1572


<210>  81
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized KAH

<400>  81
atggaagtca ctgtcgcctc ttctgtcgct ttatccttag tcttcatttc cattgtcgtc       60

agatgggctt ggtccgttgt caactgggtt tggttcaaac caaagaagtt ggaaagattc      120

ttgagagagc aaggtttgaa gggtaattct tatagattct tgtacggtga catgaaggaa      180

aattctattt tgttgaagca agccagatcc aaaccaatga acttgtctac ctctcatgat      240

attgctccac aagttactcc attcgtcgat caaactgtta aagcctacgg taagaactct      300

ttcaattggg ttggtccaat tcctagagtt aacatcatga acccagaaga tttgaaggat      360

gtcttgacca agaacgttga cttcgttaag ccaatttcca acccattgat taaattgttg      420

gctactggta ttgccattta cgaaggtgaa aagtggacta agcatagaag aatcatcaac      480

cctaccttcc actctgaaag attgaagaga atgttaccat ctttccatca atcctgtaat      540

gaaatggtta aggaatggga atccttggtt tctaaagaag gttcttcttg cgaattggat      600

gtttggccat tcttggaaaa tatgtctgct gatgtcattt ccagaaccgc tttcggtacc      660

tcctacaaga agggtcaaaa gattttcgaa ttgttgagag agcaagttat ttacgttacc      720

aagggtttcc aatccttcta catcccaggt tggagattct tgccaactaa aatgaacaag      780

cgtatgaacg agatcaacga agaaattaaa ggtttgatca gaggtattat tatcgacaga      840

gaacaaatta ttaaagctgg tgaagaaacc aacgatgatt tgttgggtgc tttgatggag      900

tccaacttga aggatattag agaacatggt aagaacaaca agaatgttgg tatgtctatt      960

gaagatgtta ttcaagaatg taagttattc tacttcgctg gtcaagagac cacttctgtt     1020

ttgttagcct ggactatggt cttgttaggt caaaaccaaa attggcaaga tagagctaga     1080

caagaagttt tgcaagtctt cggttcttcc aagccagact ttgatggttt ggcccacttg     1140

aaggttgtta ctatgatttt gttagaagtt ttgagattgt acccaccagt cattgagtta     1200

atcagaacca ttcataaaaa gactcaattg ggtaaattat ctttgccaga aggtgttgaa     1260

gtcagattac caaccttgtt gattcaccac gataaggaat tatggggtga cgacgctaat     1320

caatttaatc cagaaagatt ttccgaaggt gtttccaagg ctaccaaaaa ccgtttgtcc     1380

ttcttcccat ttggtgctgg tccacgtatt tgtatcggtc aaaacttttc catgatggaa     1440

gccaagttgg ctttggcttt aatcttgcaa cacttcactt tcgaattgtc tccatcccat     1500

gcccacgctc cttctcatag aatcacttta caaccacaat acggtgtcag aatcatctta     1560

cacagaagat aa                                                         1572


<210>  82
<211>  523
<212>  PRT
<213>  Rubus suavissimus

<400>  82

Met Glu Val Thr Val Ala Ser Ser Val Ala Leu Ser Leu Val Phe Ile 
1               5                   10                  15      


Ser Ile Val Val Arg Trp Ala Trp Ser Val Val Asn Trp Val Trp Phe 
            20                  25                  30          


Lys Pro Lys Lys Leu Glu Arg Phe Leu Arg Glu Gln Gly Leu Lys Gly 
        35                  40                  45              


Asn Ser Tyr Arg Phe Leu Tyr Gly Asp Met Lys Glu Asn Ser Ile Leu 
    50                  55                  60                  


Leu Lys Gln Ala Arg Ser Lys Pro Met Asn Leu Ser Thr Ser His Asp 
65                  70                  75                  80  


Ile Ala Pro Gln Val Thr Pro Phe Val Asp Gln Thr Val Lys Ala Tyr 
                85                  90                  95      


Gly Lys Asn Ser Phe Asn Trp Val Gly Pro Ile Pro Arg Val Asn Ile 
            100                 105                 110         


Met Asn Pro Glu Asp Leu Lys Asp Val Leu Thr Lys Asn Val Asp Phe 
        115                 120                 125             


Val Lys Pro Ile Ser Asn Pro Leu Ile Lys Leu Leu Ala Thr Gly Ile 
    130                 135                 140                 


Ala Ile Tyr Glu Gly Glu Lys Trp Thr Lys His Arg Arg Ile Ile Asn 
145                 150                 155                 160 


Pro Thr Phe His Ser Glu Arg Leu Lys Arg Met Leu Pro Ser Phe His 
                165                 170                 175     


Gln Ser Cys Asn Glu Met Val Lys Glu Trp Glu Ser Leu Val Ser Lys 
            180                 185                 190         


Glu Gly Ser Ser Cys Glu Leu Asp Val Trp Pro Phe Leu Glu Asn Met 
        195                 200                 205             


Ser Ala Asp Val Ile Ser Arg Thr Ala Phe Gly Thr Ser Tyr Lys Lys 
    210                 215                 220                 


Gly Gln Lys Ile Phe Glu Leu Leu Arg Glu Gln Val Ile Tyr Val Thr 
225                 230                 235                 240 


Lys Gly Phe Gln Ser Phe Tyr Ile Pro Gly Trp Arg Phe Leu Pro Thr 
                245                 250                 255     


Lys Met Asn Lys Arg Met Asn Glu Ile Asn Glu Glu Ile Lys Gly Leu 
            260                 265                 270         


Ile Arg Gly Ile Ile Ile Asp Arg Glu Gln Ile Ile Lys Ala Gly Glu 
        275                 280                 285             


Glu Thr Asn Asp Asp Leu Leu Gly Ala Leu Met Glu Ser Asn Leu Lys 
    290                 295                 300                 


Asp Ile Arg Glu His Gly Lys Asn Asn Lys Asn Val Gly Met Ser Ile 
305                 310                 315                 320 


Glu Asp Val Ile Gln Glu Cys Lys Leu Phe Tyr Phe Ala Gly Gln Glu 
                325                 330                 335     


Thr Thr Ser Val Leu Leu Ala Trp Thr Met Val Leu Leu Gly Gln Asn 
            340                 345                 350         


Gln Asn Trp Gln Asp Arg Ala Arg Gln Glu Val Leu Gln Val Phe Gly 
        355                 360                 365             


Ser Ser Lys Pro Asp Phe Asp Gly Leu Ala His Leu Lys Val Val Thr 
    370                 375                 380                 


Met Ile Leu Leu Glu Val Leu Arg Leu Tyr Pro Pro Val Ile Glu Leu 
385                 390                 395                 400 


Ile Arg Thr Ile His Lys Lys Thr Gln Leu Gly Lys Leu Ser Leu Pro 
                405                 410                 415     


Glu Gly Val Glu Val Arg Leu Pro Thr Leu Leu Ile His His Asp Lys 
            420                 425                 430         


Glu Leu Trp Gly Asp Asp Ala Asn Gln Phe Asn Pro Glu Arg Phe Ser 
        435                 440                 445             


Glu Gly Val Ser Lys Ala Thr Lys Asn Arg Leu Ser Phe Phe Pro Phe 
    450                 455                 460                 


Gly Ala Gly Pro Arg Ile Cys Ile Gly Gln Asn Phe Ser Met Met Glu 
465                 470                 475                 480 


Ala Lys Leu Ala Leu Ala Leu Ile Leu Gln His Phe Thr Phe Glu Leu 
                485                 490                 495     


Ser Pro Ser His Ala His Ala Pro Ser His Arg Ile Thr Leu Gln Pro 
            500                 505                 510         


Gln Tyr Gly Val Arg Ile Ile Leu His Arg Arg 
        515                 520             


<210>  83
<211>  458
<212>  PRT
<213>  Stevia rebaudiana

<400>  83

Met Glu Asn Lys Thr Glu Thr Thr Val Arg Arg Arg Arg Arg Ile Ile 
1               5                   10                  15      


Leu Phe Pro Val Pro Phe Gln Gly His Ile Asn Pro Ile Leu Gln Leu 
            20                  25                  30          


Ala Asn Val Leu Tyr Ser Lys Gly Phe Ser Ile Thr Ile Phe His Thr 
        35                  40                  45              


Asn Phe Asn Lys Pro Lys Thr Ser Asn Tyr Pro His Phe Thr Phe Arg 
    50                  55                  60                  


Phe Ile Leu Asp Asn Asp Pro Gln Asp Glu Arg Ile Ser Asn Leu Pro 
65                  70                  75                  80  


Thr His Gly Pro Leu Ala Gly Met Arg Ile Pro Ile Ile Asn Glu His 
                85                  90                  95      


Gly Ala Asp Glu Leu Arg Arg Glu Leu Glu Leu Leu Met Leu Ala Ser 
            100                 105                 110         


Glu Glu Asp Glu Glu Val Ser Cys Leu Ile Thr Asp Ala Leu Trp Tyr 
        115                 120                 125             


Phe Ala Gln Ser Val Ala Asp Ser Leu Asn Leu Arg Arg Leu Val Leu 
    130                 135                 140                 


Met Thr Ser Ser Leu Phe Asn Phe His Ala His Val Ser Leu Pro Gln 
145                 150                 155                 160 


Phe Asp Glu Leu Gly Tyr Leu Asp Pro Asp Asp Lys Thr Arg Leu Glu 
                165                 170                 175     


Glu Gln Ala Ser Gly Phe Pro Met Leu Lys Val Lys Asp Ile Lys Ser 
            180                 185                 190         


Ala Tyr Ser Asn Trp Gln Ile Leu Lys Glu Ile Leu Gly Lys Met Ile 
        195                 200                 205             


Lys Gln Thr Lys Ala Ser Ser Gly Val Ile Trp Asn Ser Phe Lys Glu 
    210                 215                 220                 


Leu Glu Glu Ser Glu Leu Glu Thr Val Ile Arg Glu Ile Pro Ala Pro 
225                 230                 235                 240 


Ser Phe Leu Ile Pro Leu Pro Lys His Leu Thr Ala Ser Ser Ser Ser 
                245                 250                 255     


Leu Leu Asp His Asp Arg Thr Val Phe Gln Trp Leu Asp Gln Gln Pro 
            260                 265                 270         


Pro Ser Ser Val Leu Tyr Val Ser Phe Gly Ser Thr Ser Glu Val Asp 
        275                 280                 285             


Glu Lys Asp Phe Leu Glu Ile Ala Arg Gly Leu Val Asp Ser Lys Gln 
    290                 295                 300                 


Ser Phe Leu Trp Val Val Arg Pro Gly Phe Val Lys Gly Ser Thr Trp 
305                 310                 315                 320 


Val Glu Pro Leu Pro Asp Gly Phe Leu Gly Glu Arg Gly Arg Ile Val 
                325                 330                 335     


Lys Trp Val Pro Gln Gln Glu Val Leu Ala His Gly Ala Ile Gly Ala 
            340                 345                 350         


Phe Trp Thr His Ser Gly Trp Asn Ser Thr Leu Glu Ser Val Cys Glu 
        355                 360                 365             


Gly Val Pro Met Ile Phe Ser Asp Phe Gly Leu Asp Gln Pro Leu Asn 
    370                 375                 380                 


Ala Arg Tyr Met Ser Asp Val Leu Lys Val Gly Val Tyr Leu Glu Asn 
385                 390                 395                 400 


Gly Trp Glu Arg Gly Glu Ile Ala Asn Ala Ile Arg Arg Val Met Val 
                405                 410                 415     


Asp Glu Glu Gly Glu Tyr Ile Arg Gln Asn Ala Arg Val Leu Lys Gln 
            420                 425                 430         


Lys Ala Asp Val Ser Leu Met Lys Gly Gly Ser Ser Tyr Glu Ser Leu 
        435                 440                 445             


Glu Ser Leu Val Ser Tyr Ile Ser Ser Leu 
    450                 455             


<210>  84
<211>  480
<212>  PRT
<213>  Stevia rebaudiana

<400>  84

Met Asp Ala Met Ala Thr Thr Glu Lys Lys Pro His Val Ile Phe Ile 
1               5                   10                  15      


Pro Phe Pro Ala Gln Ser His Ile Lys Ala Met Leu Lys Leu Ala Gln 
            20                  25                  30          


Leu Leu His His Lys Gly Leu Gln Ile Thr Phe Val Asn Thr Asp Phe 
        35                  40                  45              


Ile His Asn Gln Phe Leu Glu Ser Ser Gly Pro His Cys Leu Asp Gly 
    50                  55                  60                  


Ala Pro Gly Phe Arg Phe Glu Thr Ile Pro Asp Gly Val Ser His Ser 
65                  70                  75                  80  


Pro Glu Ala Ser Ile Pro Ile Arg Glu Ser Leu Leu Arg Ser Ile Glu 
                85                  90                  95      


Thr Asn Phe Leu Asp Arg Phe Ile Asp Leu Val Thr Lys Leu Pro Asp 
            100                 105                 110         


Pro Pro Thr Cys Ile Ile Ser Asp Gly Phe Leu Ser Val Phe Thr Ile 
        115                 120                 125             


Asp Ala Ala Lys Lys Leu Gly Ile Pro Val Met Met Tyr Trp Thr Leu 
    130                 135                 140                 


Ala Ala Cys Gly Phe Met Gly Phe Tyr His Ile His Ser Leu Ile Glu 
145                 150                 155                 160 


Lys Gly Phe Ala Pro Leu Lys Asp Ala Ser Tyr Leu Thr Asn Gly Tyr 
                165                 170                 175     


Leu Asp Thr Val Ile Asp Trp Val Pro Gly Met Glu Gly Ile Arg Leu 
            180                 185                 190         


Lys Asp Phe Pro Leu Asp Trp Ser Thr Asp Leu Asn Asp Lys Val Leu 
        195                 200                 205             


Met Phe Thr Thr Glu Ala Pro Gln Arg Ser His Lys Val Ser His His 
    210                 215                 220                 


Ile Phe His Thr Phe Asp Glu Leu Glu Pro Ser Ile Ile Lys Thr Leu 
225                 230                 235                 240 


Ser Leu Arg Tyr Asn His Ile Tyr Thr Ile Gly Pro Leu Gln Leu Leu 
                245                 250                 255     


Leu Asp Gln Ile Pro Glu Glu Lys Lys Gln Thr Gly Ile Thr Ser Leu 
            260                 265                 270         


His Gly Tyr Ser Leu Val Lys Glu Glu Pro Glu Cys Phe Gln Trp Leu 
        275                 280                 285             


Gln Ser Lys Glu Pro Asn Ser Val Val Tyr Val Asn Phe Gly Ser Thr 
    290                 295                 300                 


Thr Val Met Ser Leu Glu Asp Met Thr Glu Phe Gly Trp Gly Leu Ala 
305                 310                 315                 320 


Asn Ser Asn His Tyr Phe Leu Trp Ile Ile Arg Ser Asn Leu Val Ile 
                325                 330                 335     


Gly Glu Asn Ala Val Leu Pro Pro Glu Leu Glu Glu His Ile Lys Lys 
            340                 345                 350         


Arg Gly Phe Ile Ala Ser Trp Cys Ser Gln Glu Lys Val Leu Lys His 
        355                 360                 365             


Pro Ser Val Gly Gly Phe Leu Thr His Cys Gly Trp Gly Ser Thr Ile 
    370                 375                 380                 


Glu Ser Leu Ser Ala Gly Val Pro Met Ile Cys Trp Pro Tyr Ser Trp 
385                 390                 395                 400 


Asp Gln Leu Thr Asn Cys Arg Tyr Ile Cys Lys Glu Trp Glu Val Gly 
                405                 410                 415     


Leu Glu Met Gly Thr Lys Val Lys Arg Asp Glu Val Lys Arg Leu Val 
            420                 425                 430         


Gln Glu Leu Met Gly Glu Gly Gly His Lys Met Arg Asn Lys Ala Lys 
        435                 440                 445             


Asp Trp Lys Glu Lys Ala Arg Ile Ala Ile Ala Pro Asn Gly Ser Ser 
    450                 455                 460                 


Ser Leu Asn Ile Asp Lys Met Val Lys Glu Ile Thr Val Leu Ala Arg 
465                 470                 475                 480 


<210>  85
<211>  457
<212>  PRT
<213>  Stevia rebaudiana

<400>  85

Met Ala Thr Ser Asp Ser Ile Val Asp Asp Arg Lys Gln Leu His Val 
1               5                   10                  15      


Ala Thr Phe Pro Trp Leu Ala Phe Gly His Ile Leu Pro Tyr Leu Gln 
            20                  25                  30          


Leu Ser Lys Leu Ile Ala Glu Lys Gly His Lys Val Ser Phe Leu Ser 
        35                  40                  45              


Thr Thr Arg Asn Ile Gln Arg Leu Ser Ser His Ile Ser Pro Leu Ile 
    50                  55                  60                  


Asn Val Val Gln Leu Thr Leu Pro Arg Val Gln Glu Leu Pro Glu Asp 
65                  70                  75                  80  


Ala Glu Ala Thr Thr Asp Val His Pro Glu Asp Ile Pro Tyr Leu Lys 
                85                  90                  95      


Lys Ala Ser Asp Gly Leu Gln Pro Glu Val Thr Arg Phe Leu Glu Gln 
            100                 105                 110         


His Ser Pro Asp Trp Ile Ile Tyr Asp Tyr Thr His Tyr Trp Leu Pro 
        115                 120                 125             


Ser Ile Ala Ala Ser Leu Gly Ile Ser Arg Ala His Phe Ser Val Thr 
    130                 135                 140                 


Thr Pro Trp Ala Ile Ala Tyr Met Gly Pro Ser Ala Asp Ala Met Ile 
145                 150                 155                 160 


Asn Gly Ser Asp Gly Arg Thr Thr Val Glu Asp Leu Thr Thr Pro Pro 
                165                 170                 175     


Lys Trp Phe Pro Phe Pro Thr Lys Val Cys Trp Arg Lys His Asp Leu 
            180                 185                 190         


Ala Arg Leu Val Pro Tyr Lys Ala Pro Gly Ile Ser Asp Gly Tyr Arg 
        195                 200                 205             


Met Gly Leu Val Leu Lys Gly Ser Asp Cys Leu Leu Ser Lys Cys Tyr 
    210                 215                 220                 


His Glu Phe Gly Thr Gln Trp Leu Pro Leu Leu Glu Thr Leu His Gln 
225                 230                 235                 240 


Val Pro Val Val Pro Val Gly Leu Leu Pro Pro Glu Ile Pro Gly Asp 
                245                 250                 255     


Glu Lys Asp Glu Thr Trp Val Ser Ile Lys Lys Trp Leu Asp Gly Lys 
            260                 265                 270         


Gln Lys Gly Ser Val Val Tyr Val Ala Leu Gly Ser Glu Val Leu Val 
        275                 280                 285             


Ser Gln Thr Glu Val Val Glu Leu Ala Leu Gly Leu Glu Leu Ser Gly 
    290                 295                 300                 


Leu Pro Phe Val Trp Ala Tyr Arg Lys Pro Lys Gly Pro Ala Lys Ser 
305                 310                 315                 320 


Asp Ser Val Glu Leu Pro Asp Gly Phe Val Glu Arg Thr Arg Asp Arg 
                325                 330                 335     


Gly Leu Val Trp Thr Ser Trp Ala Pro Gln Leu Arg Ile Leu Ser His 
            340                 345                 350         


Glu Ser Val Cys Gly Phe Leu Thr His Cys Gly Ser Gly Ser Ile Val 
        355                 360                 365             


Glu Gly Leu Met Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Gly 
    370                 375                 380                 


Glu Ile Pro Arg Asn Glu Glu Asp Gly Cys Leu Thr Lys Glu Ser Val 
385                 390                 395                 400 


Ala Arg Ser Leu Arg Ser Val Val Val Glu Lys Glu Gly Glu Ile Tyr 
                405                 410                 415     


Lys Ala Asn Ala Arg Glu Leu Ser Lys Ile Tyr Asn Asp Thr Lys Val 
            420                 425                 430         


Glu Lys Glu Tyr Val Ser Gln Phe Val Asp Tyr Leu Glu Lys Asn Ala 
        435                 440                 445             


Arg Ala Val Ala Ile Asp His Glu Ser 
    450                 455         


<210>  86
<211>  462
<212>  PRT
<213>  Oryza sativa

<400>  86

Met Asp Ser Gly Tyr Ser Ser Ser Tyr Ala Ala Ala Ala Gly Met His 
1               5                   10                  15      


Val Val Ile Cys Pro Trp Leu Ala Phe Gly His Leu Leu Pro Cys Leu 
            20                  25                  30          


Asp Leu Ala Gln Arg Leu Ala Ser Arg Gly His Arg Val Ser Phe Val 
        35                  40                  45              


Ser Thr Pro Arg Asn Ile Ser Arg Leu Pro Pro Val Arg Pro Ala Leu 
    50                  55                  60                  


Ala Pro Leu Val Ala Phe Val Ala Leu Pro Leu Pro Arg Val Glu Gly 
65                  70                  75                  80  


Leu Pro Asp Gly Ala Glu Ser Thr Asn Asp Val Pro His Asp Arg Pro 
                85                  90                  95      


Asp Met Val Glu Leu His Arg Arg Ala Phe Asp Gly Leu Ala Ala Pro 
            100                 105                 110         


Phe Ser Glu Phe Leu Gly Thr Ala Cys Ala Asp Trp Val Ile Val Asp 
        115                 120                 125             


Val Phe His His Trp Ala Ala Ala Ala Ala Leu Glu His Lys Val Pro 
    130                 135                 140                 


Cys Ala Met Met Leu Leu Gly Ser Ala His Met Ile Ala Ser Ile Ala 
145                 150                 155                 160 


Asp Arg Arg Leu Glu Arg Ala Glu Thr Glu Ser Pro Ala Ala Ala Gly 
                165                 170                 175     


Gln Gly Arg Pro Ala Ala Ala Pro Thr Phe Glu Val Ala Arg Met Lys 
            180                 185                 190         


Leu Ile Arg Thr Lys Gly Ser Ser Gly Met Ser Leu Ala Glu Arg Phe 
        195                 200                 205             


Ser Leu Thr Leu Ser Arg Ser Ser Leu Val Val Gly Arg Ser Cys Val 
    210                 215                 220                 


Glu Phe Glu Pro Glu Thr Val Pro Leu Leu Ser Thr Leu Arg Gly Lys 
225                 230                 235                 240 


Pro Ile Thr Phe Leu Gly Leu Met Pro Pro Leu His Glu Gly Arg Arg 
                245                 250                 255     


Glu Asp Gly Glu Asp Ala Thr Val Arg Trp Leu Asp Ala Gln Pro Ala 
            260                 265                 270         


Lys Ser Val Val Tyr Val Ala Leu Gly Ser Glu Val Pro Leu Gly Val 
        275                 280                 285             


Glu Lys Val His Glu Leu Ala Leu Gly Leu Glu Leu Ala Gly Thr Arg 
    290                 295                 300                 


Phe Leu Trp Ala Leu Arg Lys Pro Thr Gly Val Ser Asp Ala Asp Leu 
305                 310                 315                 320 


Leu Pro Ala Gly Phe Glu Glu Arg Thr Arg Gly Arg Gly Val Val Ala 
                325                 330                 335     


Thr Arg Trp Val Pro Gln Met Ser Ile Leu Ala His Ala Ala Val Gly 
            340                 345                 350         


Ala Phe Leu Thr His Cys Gly Trp Asn Ser Thr Ile Glu Gly Leu Met 
        355                 360                 365             


Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Gly Asp Gln Gly Pro 
    370                 375                 380                 


Asn Ala Arg Leu Ile Glu Ala Lys Asn Ala Gly Leu Gln Val Ala Arg 
385                 390                 395                 400 


Asn Asp Gly Asp Gly Ser Phe Asp Arg Glu Gly Val Ala Ala Ala Ile 
                405                 410                 415     


Arg Ala Val Ala Val Glu Glu Glu Ser Ser Lys Val Phe Gln Ala Lys 
            420                 425                 430         


Ala Lys Lys Leu Gln Glu Ile Val Ala Asp Met Ala Cys His Glu Arg 
        435                 440                 445             


Tyr Ile Asp Gly Phe Ile Gln Gln Leu Arg Ser Tyr Lys Asp 
    450                 455                 460         


<210>  87
<211>  712
<212>  PRT
<213>  Arabidopsis thaliana

<400>  87

Met Ser Ser Ser Ser Ser Ser Ser Thr Ser Met Ile Asp Leu Met Ala 
1               5                   10                  15      


Ala Ile Ile Lys Gly Glu Pro Val Ile Val Ser Asp Pro Ala Asn Ala 
            20                  25                  30          


Ser Ala Tyr Glu Ser Val Ala Ala Glu Leu Ser Ser Met Leu Ile Glu 
        35                  40                  45              


Asn Arg Gln Phe Ala Met Ile Val Thr Thr Ser Ile Ala Val Leu Ile 
    50                  55                  60                  


Gly Cys Ile Val Met Leu Val Trp Arg Arg Ser Gly Ser Gly Asn Ser 
65                  70                  75                  80  


Lys Arg Val Glu Pro Leu Lys Pro Leu Val Ile Lys Pro Arg Glu Glu 
                85                  90                  95      


Glu Ile Asp Asp Gly Arg Lys Lys Val Thr Ile Phe Phe Gly Thr Gln 
            100                 105                 110         


Thr Gly Thr Ala Glu Gly Phe Ala Lys Ala Leu Gly Glu Glu Ala Lys 
        115                 120                 125             


Ala Arg Tyr Glu Lys Thr Arg Phe Lys Ile Val Asp Leu Asp Asp Tyr 
    130                 135                 140                 


Ala Ala Asp Asp Asp Glu Tyr Glu Glu Lys Leu Lys Lys Glu Asp Val 
145                 150                 155                 160 


Ala Phe Phe Phe Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn 
                165                 170                 175     


Ala Ala Arg Phe Tyr Lys Trp Phe Thr Glu Gly Asn Asp Arg Gly Glu 
            180                 185                 190         


Trp Leu Lys Asn Leu Lys Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln 
        195                 200                 205             


Tyr Glu His Phe Asn Lys Val Ala Lys Val Val Asp Asp Ile Leu Val 
    210                 215                 220                 


Glu Gln Gly Ala Gln Arg Leu Val Gln Val Gly Leu Gly Asp Asp Asp 
225                 230                 235                 240 


Gln Cys Ile Glu Asp Asp Phe Thr Ala Trp Arg Glu Ala Leu Trp Pro 
                245                 250                 255     


Glu Leu Asp Thr Ile Leu Arg Glu Glu Gly Asp Thr Ala Val Ala Thr 
            260                 265                 270         


Pro Tyr Thr Ala Ala Val Leu Glu Tyr Arg Val Ser Ile His Asp Ser 
        275                 280                 285             


Glu Asp Ala Lys Phe Asn Asp Ile Thr Leu Ala Asn Gly Asn Gly Tyr 
    290                 295                 300                 


Thr Val Phe Asp Ala Gln His Pro Tyr Lys Ala Asn Val Ala Val Lys 
305                 310                 315                 320 


Arg Glu Leu His Thr Pro Glu Ser Asp Arg Ser Cys Ile His Leu Glu 
                325                 330                 335     


Phe Asp Ile Ala Gly Ser Gly Leu Thr Met Lys Leu Gly Asp His Val 
            340                 345                 350         


Gly Val Leu Cys Asp Asn Leu Ser Glu Thr Val Asp Glu Ala Leu Arg 
        355                 360                 365             


Leu Leu Asp Met Ser Pro Asp Thr Tyr Phe Ser Leu His Ala Glu Lys 
    370                 375                 380                 


Glu Asp Gly Thr Pro Ile Ser Ser Ser Leu Pro Pro Pro Phe Pro Pro 
385                 390                 395                 400 


Cys Asn Leu Arg Thr Ala Leu Thr Arg Tyr Ala Cys Leu Leu Ser Ser 
                405                 410                 415     


Pro Lys Lys Ser Ala Leu Val Ala Leu Ala Ala His Ala Ser Asp Pro 
            420                 425                 430         


Thr Glu Ala Glu Arg Leu Lys His Leu Ala Ser Pro Ala Gly Lys Asp 
        435                 440                 445             


Glu Tyr Ser Lys Trp Val Val Glu Ser Gln Arg Ser Leu Leu Glu Val 
    450                 455                 460                 


Met Ala Glu Phe Pro Ser Ala Lys Pro Pro Leu Gly Val Phe Phe Ala 
465                 470                 475                 480 


Gly Val Ala Pro Arg Leu Gln Pro Arg Phe Tyr Ser Ile Ser Ser Ser 
                485                 490                 495     


Pro Lys Ile Ala Glu Thr Arg Ile His Val Thr Cys Ala Leu Val Tyr 
            500                 505                 510         


Glu Lys Met Pro Thr Gly Arg Ile His Lys Gly Val Cys Ser Thr Trp 
        515                 520                 525             


Met Lys Asn Ala Val Pro Tyr Glu Lys Ser Glu Lys Leu Phe Leu Gly 
    530                 535                 540                 


Arg Pro Ile Phe Val Arg Gln Ser Asn Phe Lys Leu Pro Ser Asp Ser 
545                 550                 555                 560 


Lys Val Pro Ile Ile Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe 
                565                 570                 575     


Arg Gly Phe Leu Gln Glu Arg Leu Ala Leu Val Glu Ser Gly Val Glu 
            580                 585                 590         


Leu Gly Pro Ser Val Leu Phe Phe Gly Cys Arg Asn Arg Arg Met Asp 
        595                 600                 605             


Phe Ile Tyr Glu Glu Glu Leu Gln Arg Phe Val Glu Ser Gly Ala Leu 
    610                 615                 620                 


Ala Glu Leu Ser Val Ala Phe Ser Arg Glu Gly Pro Thr Lys Glu Tyr 
625                 630                 635                 640 


Val Gln His Lys Met Met Asp Lys Ala Ser Asp Ile Trp Asn Met Ile 
                645                 650                 655     


Ser Gln Gly Ala Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala 
            660                 665                 670         


Arg Asp Val His Arg Ser Leu His Thr Ile Ala Gln Glu Gln Gly Ser 
        675                 680                 685             


Met Asp Ser Thr Lys Ala Glu Gly Phe Val Lys Asn Leu Gln Thr Ser 
    690                 695                 700                 


Gly Arg Tyr Leu Arg Asp Val Trp 
705                 710         


<210>  88
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  88

Met Ala Thr Ser Asp Ser Ile Val Asp Asp Arg Lys Gln Leu His Val 
1               5                   10                  15      


Ala Thr Phe Pro Trp Leu Ala Phe Gly His Ile Leu Pro Tyr Leu Gln 
            20                  25                  30          


Leu Ser Lys Leu Ile Ala Glu Lys Gly His Lys Val Ser Phe Leu Ser 
        35                  40                  45              


Thr Thr Arg Asn Ile Gln Arg Leu Ser Ser His Ile Ser Pro Leu Ile 
    50                  55                  60                  


Asn Val Val Gln Leu Thr Leu Pro Arg Val Gln Glu Leu Pro Glu Asp 
65                  70                  75                  80  


Ala Glu Ala Thr Thr Asp Val His Pro Glu Asp Ile Pro Tyr Leu Lys 
                85                  90                  95      


Lys Ala Ser Asp Gly Leu Gln Pro Glu Val Thr Arg Phe Leu Glu Gln 
            100                 105                 110         


His Ser Pro Asp Trp Ile Ile Tyr Asp Tyr Thr His Tyr Trp Leu Pro 
        115                 120                 125             


Ser Ile Ala Ala Ser Leu Gly Ile Ser Arg Ala His Phe Ser Val Thr 
    130                 135                 140                 


Thr Pro Trp Ala Ile Ala Tyr Met Gly Pro Ser Ala Asp Ala Met Ile 
145                 150                 155                 160 


Asn Gly Ser Asp Gly Arg Thr Thr Val Glu Asp Leu Thr Thr Pro Pro 
                165                 170                 175     


Lys Trp Phe Pro Phe Pro Thr Lys Val Cys Trp Arg Lys His Asp Leu 
            180                 185                 190         


Ala Arg Leu Val Pro Tyr Lys Ala Pro Gly Ile Ser Asp Gly Tyr Arg 
        195                 200                 205             


Met Gly Met Val Leu Lys Gly Ser Asp Cys Leu Leu Ser Lys Cys Tyr 
    210                 215                 220                 


His Glu Phe Gly Thr Gln Trp Leu Pro Leu Leu Glu Thr Leu His Gln 
225                 230                 235                 240 


Val Pro Val Val Pro Val Gly Leu Leu Pro Pro Glu Ile Pro Gly Asp 
                245                 250                 255     


Glu Lys Asp Glu Thr Trp Val Ser Ile Lys Lys Trp Leu Asp Gly Lys 
            260                 265                 270         


Gln Lys Gly Ser Val Val Tyr Val Ala Leu Gly Ser Glu Ala Leu Val 
        275                 280                 285             


Ser Gln Thr Glu Val Val Glu Leu Ala Leu Gly Leu Glu Leu Ser Gly 
    290                 295                 300                 


Leu Pro Phe Val Trp Ala Tyr Arg Lys Pro Lys Gly Pro Ala Lys Ser 
305                 310                 315                 320 


Asp Ser Val Glu Leu Pro Asp Gly Phe Val Glu Arg Thr Arg Asp Arg 
                325                 330                 335     


Gly Leu Val Trp Thr Ser Trp Ala Pro Gln Leu Arg Ile Leu Ser His 
            340                 345                 350         


Glu Ser Val Cys Gly Phe Leu Thr His Cys Gly Ser Gly Ser Ile Val 
        355                 360                 365             


Glu Gly Leu Met Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Gly 
    370                 375                 380                 


Asp Gln Pro Leu Asn Ala Arg Leu Leu Glu Asp Lys Gln Val Gly Ile 
385                 390                 395                 400 


Glu Ile Pro Arg Asn Glu Glu Asp Gly Cys Leu Thr Lys Glu Ser Val 
                405                 410                 415     


Ala Arg Ser Leu Arg Ser Val Val Val Glu Lys Glu Gly Glu Ile Tyr 
            420                 425                 430         


Lys Ala Asn Ala Arg Glu Leu Ser Lys Ile Tyr Asn Asp Thr Lys Val 
        435                 440                 445             


Glu Lys Glu Tyr Val Ser Gln Phe Val Asp Tyr Leu Glu Lys Asn Ala 
    450                 455                 460                 


Arg Ala Val Ala Ile Asp His Glu Ser 
465                 470             


<210>  89
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  89
atggctactt ctgattccat cgttgacgat agaaagcaat tgcatgttgc tacttttcca       60

tggttggctt tcggtcatat tttgccatac ttgcaattgt ccaagttgat tgctgaaaag      120

ggtcacaagg tttcattctt gtctaccacc agaaacatcc aaagattgtc ctctcatatc      180

tccccattga tcaacgttgt tcaattgact ttgccaagag tccaagaatt gccagaagat      240

gctgaagcta ctactgatgt tcatccagaa gatatccctt acttgaaaaa ggcttccgat      300

ggtttacaac cagaagttac tagattcttg gaacaacatt ccccagattg gatcatctac      360

gattatactc attactggtt gccatccatt gctgcttcat tgggtatttc tagagcccat      420

ttctctgtta ctactccatg ggctattgct tatatgggtc catctgctga tgctatgatt      480

aacggttctg atggtagaac taccgttgaa gatttgacta ctccaccaaa gtggtttcca      540

tttccaacaa aagtctgttg gagaaaacac gatttggcta gattggttcc atacaaagct      600

ccaggtattt ctgatggtta cagaatgggt atggttttga aaggttccga ttgcttgttg      660

tctaagtgct atcatgaatt cggtactcaa tggttgcctt tgttggaaac attgcatcaa      720

gttccagttg ttccagtagg tttgttgcca ccagaaattc caggtgacga aaaagacgaa      780

acttgggttt ccatcaaaaa gtggttggat ggtaagcaaa agggttctgt tgtttatgtt      840

gctttgggtt ccgaagcttt ggtttctcaa accgaagttg ttgaattggc tttgggtttg      900

gaattgtctg gtttgccatt tgtttgggct tacagaaaac ctaaaggtcc agctaagtct      960

gattctgttg aattgccaga tggtttcgtt gaaagaacta gagatagagg tttggtttgg     1020

acttcttggg ctccacaatt gagaattttg tctcatgaat ccgtctgtgg tttcttgact     1080

cattgtggtt ctggttctat cgttgaaggt ttgatgtttg gtcacccatt gattatgttg     1140

ccaatctttg gtgaccaacc attgaacgct agattattgg aagataagca agtcggtatc     1200

gaaatcccaa gaaatgaaga agatggttgc ttgaccaaag aatctgttgc tagatctttg     1260

agatccgttg tcgttgaaaa agaaggtgaa atctacaagg ctaacgctag agaattgtcc     1320

aagatctaca acgataccaa ggtcgaaaaa gaatacgttt cccaattcgt tgactacttg     1380

gaaaagaatg ctagagctgt tgccattgat catgaatctt ga                        1422


<210>  90
<211>  1567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  90
atggaagctt ctagagcatc ttgtgttgct ttgtgtgttg tttgggtttc catcgttatt       60

actttggctt ggagagtttt gaattgggtc tggttaagac caaaaaagtt ggaaagatgc      120

ttgagagaac aaggtttgac tggtaactct tacagattgt tgttcggtga taccaaggac      180

ttgtctaaga tgttggaaca aactcaatcc aagcctatca agttgtctac ctctcatgat      240

attgctccaa gagttactcc attcttccat agaactgtta actccaacgg taagaactct      300

tttgtttgga tgggtccaat tccaagagtc catattatga accctgaaga tttgaaggac      360

gctttcaaca gacatgatga tttccataag accgtcaaga acccaattat gaagtctcca      420

ccaccaggta tagttggtat tgaaggtgaa caatgggcca aacatagaaa gattattaac      480

ccagccttcc acttggaaaa gttgaaaggt atggttccaa tcttctacca atcctgctct      540

gaaatgatta acaagtggga atccttggtt tccaaagaat cttcctgtga attggatgtc      600

tggccatatt tggaaaactt cacctccgat gttatttcca gagctgcttt tggttcttct      660

tacgaagaag gtagaaagat cttccaatta ttgagagaag aagccaaggt ttactccgtt      720

gctttgagat ctgtttacat tccaggttgg agattcttgc caactaagca aaacaaaaag      780

accaaagaaa tccacaacga aatcaagggt ttgttgaagg gtatcatcaa caagagagaa      840

gaagctatga aggctggtga agctacaaaa gatgatttgt tgggtatctt gatggaatcc      900

aacttcagag aaatccaaga acacggtaac aacaagaatg ccggtatgtc tattgaagat      960

gttatcggtg aatgcaagtt gttctacttt gctggtcaag aaactacctc cgttttgttg     1020

gtttggacca tgattttgtt gtcccaaaat caagattggc aagctagagc tagagaagaa     1080

gtcttgaaag ttttcggttc taacatccca acctacgaag aattgtctca cttgaaggtt     1140

gtcactatga tcttgttgga agtattgaga ttatacccat ccgttgttgc attgccaaga     1200

actactcata agaaaactca attgggtaaa ttgtccttgc cagctggtgt tgaagtttct     1260

ttgccaattt tgttagtcca ccacgacaaa gaattgtggg gtgaagatgc taatgaattc     1320

aagccagaaa gattctccga aggtgtttct aaagctacca agaacaagtt cacttacttg     1380

ccatttggtg gtggtccaag aatatgtatt ggtcaaaatt tcgctatggt cgaagctaaa     1440

ttggctttgg ctttgatctt gcaacatttc gctttcgaat tgtcaccatc ttatgctcat     1500

gctccatctg ctgttattac attgcaacca caatttggtg cccatatcat cttgcataag     1560

agataac                                                               1567


<210>  91
<211>  521
<212>  PRT
<213>  Prunus avium

<400>  91

Met Glu Ala Ser Arg Ala Ser Cys Val Ala Leu Cys Val Val Trp Val 
1               5                   10                  15      


Ser Ile Val Ile Thr Leu Ala Trp Arg Val Leu Asn Trp Val Trp Leu 
            20                  25                  30          


Arg Pro Lys Lys Leu Glu Arg Cys Leu Arg Glu Gln Gly Leu Thr Gly 
        35                  40                  45              


Asn Ser Tyr Arg Leu Leu Phe Gly Asp Thr Lys Asp Leu Ser Lys Met 
    50                  55                  60                  


Leu Glu Gln Thr Gln Ser Lys Pro Ile Lys Leu Ser Thr Ser His Asp 
65                  70                  75                  80  


Ile Ala Pro Arg Val Thr Pro Phe Phe His Arg Thr Val Asn Ser Asn 
                85                  90                  95      


Gly Lys Asn Ser Phe Val Trp Met Gly Pro Ile Pro Arg Val His Ile 
            100                 105                 110         


Met Asn Pro Glu Asp Leu Lys Asp Ala Phe Asn Arg His Asp Asp Phe 
        115                 120                 125             


His Lys Thr Val Lys Asn Pro Ile Met Lys Ser Pro Pro Pro Gly Ile 
    130                 135                 140                 


Val Gly Ile Glu Gly Glu Gln Trp Ala Lys His Arg Lys Ile Ile Asn 
145                 150                 155                 160 


Pro Ala Phe His Leu Glu Lys Leu Lys Gly Met Val Pro Ile Phe Tyr 
                165                 170                 175     


Gln Ser Cys Ser Glu Met Ile Asn Lys Trp Glu Ser Leu Val Ser Lys 
            180                 185                 190         


Glu Ser Ser Cys Glu Leu Asp Val Trp Pro Tyr Leu Glu Asn Phe Thr 
        195                 200                 205             


Ser Asp Val Ile Ser Arg Ala Ala Phe Gly Ser Ser Tyr Glu Glu Gly 
    210                 215                 220                 


Arg Lys Ile Phe Gln Leu Leu Arg Glu Glu Ala Lys Val Tyr Ser Val 
225                 230                 235                 240 


Ala Leu Arg Ser Val Tyr Ile Pro Gly Trp Arg Phe Leu Pro Thr Lys 
                245                 250                 255     


Gln Asn Lys Lys Thr Lys Glu Ile His Asn Glu Ile Lys Gly Leu Leu 
            260                 265                 270         


Lys Gly Ile Ile Asn Lys Arg Glu Glu Ala Met Lys Ala Gly Glu Ala 
        275                 280                 285             


Thr Lys Asp Asp Leu Leu Gly Ile Leu Met Glu Ser Asn Phe Arg Glu 
    290                 295                 300                 


Ile Gln Glu His Gly Asn Asn Lys Asn Ala Gly Met Ser Ile Glu Asp 
305                 310                 315                 320 


Val Ile Gly Glu Cys Lys Leu Phe Tyr Phe Ala Gly Gln Glu Thr Thr 
                325                 330                 335     


Ser Val Leu Leu Val Trp Thr Met Ile Leu Leu Ser Gln Asn Gln Asp 
            340                 345                 350         


Trp Gln Ala Arg Ala Arg Glu Glu Val Leu Lys Val Phe Gly Ser Asn 
        355                 360                 365             


Ile Pro Thr Tyr Glu Glu Leu Ser His Leu Lys Val Val Thr Met Ile 
    370                 375                 380                 


Leu Leu Glu Val Leu Arg Leu Tyr Pro Ser Val Val Ala Leu Pro Arg 
385                 390                 395                 400 


Thr Thr His Lys Lys Thr Gln Leu Gly Lys Leu Ser Leu Pro Ala Gly 
                405                 410                 415     


Val Glu Val Ser Leu Pro Ile Leu Leu Val His His Asp Lys Glu Leu 
            420                 425                 430         


Trp Gly Glu Asp Ala Asn Glu Phe Lys Pro Glu Arg Phe Ser Glu Gly 
        435                 440                 445             


Val Ser Lys Ala Thr Lys Asn Lys Phe Thr Tyr Leu Pro Phe Gly Gly 
    450                 455                 460                 


Gly Pro Arg Ile Cys Ile Gly Gln Asn Phe Ala Met Val Glu Ala Lys 
465                 470                 475                 480 


Leu Ala Leu Ala Leu Ile Leu Gln His Phe Ala Phe Glu Leu Ser Pro 
                485                 490                 495     


Ser Tyr Ala His Ala Pro Ser Ala Val Ile Thr Leu Gln Pro Gln Phe 
            500                 505                 510         


Gly Ala His Ile Ile Leu His Lys Arg 
        515                 520     


<210>  92
<211>  517
<212>  PRT
<213>  Prunus mume

<400>  92

Ala Ser Trp Val Ala Val Leu Ser Val Val Trp Val Ser Met Val Ile 
1               5                   10                  15      


Ala Trp Ala Trp Arg Val Leu Asn Trp Val Trp Leu Arg Pro Lys Lys 
            20                  25                  30          


Leu Glu Lys Cys Leu Arg Glu Gln Gly Leu Ala Gly Asn Ser Tyr Arg 
        35                  40                  45              


Leu Leu Phe Gly Asp Thr Lys Asp Leu Ser Lys Met Leu Glu Gln Thr 
    50                  55                  60                  


Gln Ser Lys Pro Ile Lys Leu Ser Thr Ser His Asp Ile Ala Pro His 
65                  70                  75                  80  


Val Thr Pro Phe Phe His Gln Thr Val Asn Ser Tyr Gly Lys Asn Ser 
                85                  90                  95      


Phe Val Trp Met Gly Pro Ile Pro Arg Val His Ile Met Asn Pro Glu 
            100                 105                 110         


Asp Leu Lys Asp Thr Phe Asn Arg His Asp Asp Phe His Lys Val Val 
        115                 120                 125             


Lys Asn Pro Ile Met Lys Ser Leu Pro Gln Gly Ile Val Gly Ile Glu 
    130                 135                 140                 


Gly Glu Gln Trp Ala Lys His Arg Lys Ile Ile Asn Pro Ala Phe His 
145                 150                 155                 160 


Leu Glu Lys Leu Lys Gly Met Val Pro Ile Phe Tyr Arg Ser Cys Ser 
                165                 170                 175     


Glu Met Ile Asn Lys Trp Glu Ser Leu Val Ser Lys Glu Ser Ser Cys 
            180                 185                 190         


Glu Leu Asp Val Trp Pro Tyr Leu Glu Asn Phe Thr Ser Asp Val Ile 
        195                 200                 205             


Ser Arg Ala Ala Phe Gly Ser Ser Tyr Glu Glu Gly Arg Lys Ile Phe 
    210                 215                 220                 


Gln Leu Leu Arg Glu Glu Ala Lys Ile Tyr Thr Val Ala Met Arg Ser 
225                 230                 235                 240 


Val Tyr Ile Pro Gly Trp Arg Phe Leu Pro Thr Lys Gln Asn Lys Lys 
                245                 250                 255     


Ala Lys Glu Ile His Asn Glu Ile Lys Gly Leu Leu Lys Gly Ile Ile 
            260                 265                 270         


Asn Lys Arg Glu Glu Ala Met Lys Ala Gly Glu Ala Thr Lys Asp Asp 
        275                 280                 285             


Leu Leu Gly Ile Leu Met Glu Ser Asn Phe Arg Glu Ile Gln Glu His 
    290                 295                 300                 


Gly Asn Asn Lys Asn Ala Gly Met Ser Ile Glu Asp Val Ile Gly Glu 
305                 310                 315                 320 


Cys Lys Leu Phe Tyr Phe Ala Gly Gln Glu Thr Thr Ser Val Leu Leu 
                325                 330                 335     


Val Trp Thr Met Val Leu Leu Ser Gln Asn Gln Asp Trp Gln Ala Arg 
            340                 345                 350         


Ala Arg Glu Glu Val Leu Gln Val Phe Gly Ser Asn Ile Pro Thr Tyr 
        355                 360                 365             


Glu Glu Leu Ser Gln Leu Lys Val Val Thr Met Ile Leu Leu Glu Val 
    370                 375                 380                 


Leu Arg Leu Tyr Pro Ser Val Val Ala Leu Pro Arg Thr Thr His Lys 
385                 390                 395                 400 


Lys Thr Gln Leu Gly Lys Leu Ser Leu Pro Ala Gly Val Glu Val Ser 
                405                 410                 415     


Leu Pro Ile Leu Leu Val His His Asp Lys Glu Leu Trp Gly Glu Asp 
            420                 425                 430         


Ala Asn Glu Phe Lys Pro Glu Arg Phe Ser Glu Gly Val Ser Lys Ala 
        435                 440                 445             


Thr Lys Asn Gln Phe Thr Tyr Phe Pro Phe Gly Gly Gly Pro Arg Ile 
    450                 455                 460                 


Cys Ile Gly Gln Asn Phe Ala Met Met Glu Ala Lys Leu Ala Leu Ser 
465                 470                 475                 480 


Leu Ile Leu Arg His Phe Ala Leu Glu Leu Ser Pro Leu Tyr Ala His 
                485                 490                 495     


Ala Pro Ser Val Thr Ile Thr Leu Gln Pro Gln Tyr Gly Ala His Ile 
            500                 505                 510         


Ile Leu His Lys Arg 
        515         


<210>  93
<211>  521
<212>  PRT
<213>  Prunus mume

<400>  93

Met Glu Ala Ser Arg Pro Ser Cys Val Ala Leu Ser Val Val Leu Val 
1               5                   10                  15      


Ser Ile Val Ile Ala Trp Ala Trp Arg Val Leu Asn Trp Val Trp Leu 
            20                  25                  30          


Arg Pro Asn Lys Leu Glu Arg Cys Leu Arg Glu Gln Gly Leu Thr Gly 
        35                  40                  45              


Asn Ser Tyr Arg Leu Leu Phe Gly Asp Thr Lys Glu Ile Ser Met Met 
    50                  55                  60                  


Val Glu Gln Ala Gln Ser Lys Pro Ile Lys Leu Ser Thr Thr His Asp 
65                  70                  75                  80  


Ile Ala Pro Arg Val Ile Pro Phe Ser His Gln Ile Val Tyr Thr Tyr 
                85                  90                  95      


Gly Arg Asn Ser Phe Val Trp Met Gly Pro Thr Pro Arg Val Thr Ile 
            100                 105                 110         


Met Asn Pro Glu Asp Leu Lys Asp Ala Phe Asn Lys Ser Asp Glu Phe 
        115                 120                 125             


Gln Arg Ala Ile Ser Asn Pro Ile Val Lys Ser Ile Ser Gln Gly Leu 
    130                 135                 140                 


Ser Ser Leu Glu Gly Glu Lys Trp Ala Lys His Arg Lys Ile Ile Asn 
145                 150                 155                 160 


Pro Ala Phe His Leu Glu Lys Leu Lys Gly Met Leu Pro Thr Phe Tyr 
                165                 170                 175     


Gln Ser Cys Ser Glu Met Ile Asn Lys Trp Glu Ser Leu Val Phe Lys 
            180                 185                 190         


Glu Gly Ser Arg Glu Met Asp Val Trp Pro Tyr Leu Glu Asn Leu Thr 
        195                 200                 205             


Ser Asp Val Ile Ser Arg Ala Ala Phe Gly Ser Ser Tyr Glu Glu Gly 
    210                 215                 220                 


Arg Lys Ile Phe Gln Leu Leu Arg Glu Glu Ala Lys Phe Tyr Thr Ile 
225                 230                 235                 240 


Ala Ala Arg Ser Val Tyr Ile Pro Gly Trp Arg Phe Leu Pro Thr Lys 
                245                 250                 255     


Gln Asn Lys Arg Met Lys Glu Ile His Lys Glu Val Arg Gly Leu Leu 
            260                 265                 270         


Lys Gly Ile Ile Asn Lys Arg Glu Asp Ala Ile Lys Ala Gly Glu Ala 
        275                 280                 285             


Ala Lys Gly Asn Leu Leu Gly Ile Leu Met Glu Ser Asn Phe Arg Glu 
    290                 295                 300                 


Ile Gln Glu His Gly Asn Asn Lys Asn Ala Gly Met Ser Ile Glu Asp 
305                 310                 315                 320 


Val Ile Gly Glu Cys Lys Leu Phe Tyr Phe Ala Gly Gln Glu Thr Thr 
                325                 330                 335     


Ser Val Leu Leu Val Trp Thr Leu Val Leu Leu Ser Gln Asn Gln Asp 
            340                 345                 350         


Trp Gln Ala Arg Ala Arg Glu Glu Val Leu Gln Val Phe Gly Thr Asn 
        355                 360                 365             


Ile Pro Thr Tyr Asp Gln Leu Ser His Leu Lys Val Val Thr Met Ile 
    370                 375                 380                 


Leu Leu Glu Val Leu Arg Leu Tyr Pro Ala Val Val Glu Leu Pro Arg 
385                 390                 395                 400 


Thr Thr Tyr Lys Lys Thr Gln Leu Gly Lys Phe Leu Leu Pro Ala Gly 
                405                 410                 415     


Val Glu Val Ser Leu His Ile Met Leu Ala His His Asp Lys Glu Leu 
            420                 425                 430         


Trp Gly Glu Asp Ala Lys Glu Phe Lys Pro Glu Arg Phe Ser Glu Gly 
        435                 440                 445             


Val Ser Lys Ala Thr Lys Asn Gln Phe Thr Tyr Phe Pro Phe Gly Ala 
    450                 455                 460                 


Gly Pro Arg Ile Cys Ile Gly Gln Asn Phe Ala Met Leu Glu Ala Lys 
465                 470                 475                 480 


Leu Ala Leu Ser Leu Ile Leu Gln His Phe Thr Phe Glu Leu Ser Pro 
                485                 490                 495     


Ser Tyr Ala His Ala Pro Ser Val Thr Ile Thr Leu His Pro Gln Phe 
            500                 505                 510         


Gly Ala His Phe Ile Leu His Lys Arg 
        515                 520     


<210>  94
<211>  514
<212>  PRT
<213>  Prunus mume

<400>  94

Cys Val Ala Leu Ser Val Val Leu Val Ser Ile Val Ile Ala Trp Ala 
1               5                   10                  15      


Trp Arg Val Leu Asn Trp Val Trp Leu Arg Pro Asn Lys Leu Glu Arg 
            20                  25                  30          


Cys Leu Arg Glu Gln Gly Leu Thr Gly Asn Ser Tyr Arg Leu Leu Phe 
        35                  40                  45              


Gly Asp Thr Lys Glu Ile Ser Met Met Val Glu Gln Ala Gln Ser Lys 
    50                  55                  60                  


Pro Ile Lys Leu Ser Thr Thr His Asp Ile Ala Pro Arg Val Ile Pro 
65                  70                  75                  80  


Phe Ser His Gln Ile Val Tyr Thr Tyr Gly Arg Asn Ser Phe Val Trp 
                85                  90                  95      


Met Gly Pro Thr Pro Arg Val Thr Ile Met Asn Pro Glu Asp Leu Lys 
            100                 105                 110         


Asp Ala Phe Asn Lys Ser Asp Glu Phe Gln Arg Ala Ile Ser Asn Pro 
        115                 120                 125             


Ile Val Lys Ser Ile Ser Gln Gly Leu Ser Ser Leu Glu Gly Glu Lys 
    130                 135                 140                 


Trp Ala Lys His Arg Lys Ile Ile Asn Pro Ala Phe His Leu Glu Lys 
145                 150                 155                 160 


Leu Lys Gly Met Leu Pro Thr Phe Tyr Gln Ser Cys Ser Glu Met Ile 
                165                 170                 175     


Asn Lys Trp Glu Ser Leu Val Phe Lys Glu Gly Ser Arg Glu Met Asp 
            180                 185                 190         


Val Trp Pro Tyr Leu Glu Asn Leu Thr Ser Asp Val Ile Ser Arg Ala 
        195                 200                 205             


Ala Phe Gly Ser Ser Tyr Glu Glu Gly Arg Lys Ile Phe Gln Leu Leu 
    210                 215                 220                 


Arg Glu Glu Ala Lys Phe Tyr Thr Ile Ala Ala Arg Ser Val Tyr Ile 
225                 230                 235                 240 


Pro Gly Trp Arg Phe Leu Pro Thr Lys Gln Asn Lys Arg Met Lys Glu 
                245                 250                 255     


Ile His Lys Glu Val Arg Gly Leu Leu Lys Gly Ile Ile Asn Lys Arg 
            260                 265                 270         


Glu Asp Ala Ile Lys Ala Gly Glu Ala Ala Lys Gly Asn Leu Leu Gly 
        275                 280                 285             


Ile Leu Met Glu Ser Asn Phe Arg Glu Ile Gln Glu His Gly Asn Asn 
    290                 295                 300                 


Lys Asn Ala Gly Met Ser Ile Glu Asp Val Ile Gly Glu Cys Lys Leu 
305                 310                 315                 320 


Phe Tyr Phe Ala Gly Gln Glu Thr Thr Ser Val Leu Leu Val Trp Thr 
                325                 330                 335     


Leu Val Leu Leu Ser Gln Asn Gln Asp Trp Gln Ala Arg Ala Arg Glu 
            340                 345                 350         


Glu Val Leu Gln Val Phe Gly Thr Asn Ile Pro Thr Tyr Asp Gln Leu 
        355                 360                 365             


Ser His Leu Lys Val Val Thr Met Ile Leu Leu Glu Val Leu Arg Leu 
    370                 375                 380                 


Tyr Pro Ala Val Val Glu Leu Pro Arg Thr Thr Tyr Lys Lys Thr Gln 
385                 390                 395                 400 


Leu Gly Lys Phe Leu Leu Pro Ala Gly Val Glu Val Ser Leu His Ile 
                405                 410                 415     


Met Leu Ala His His Asp Lys Glu Leu Trp Gly Glu Asp Ala Lys Glu 
            420                 425                 430         


Phe Lys Pro Glu Arg Phe Ser Glu Gly Val Ser Lys Ala Thr Lys Asn 
        435                 440                 445             


Gln Phe Thr Tyr Phe Pro Phe Gly Ala Gly Pro Arg Ile Cys Ile Gly 
    450                 455                 460                 


Gln Asn Phe Ala Met Leu Glu Ala Lys Leu Ala Leu Ser Leu Ile Leu 
465                 470                 475                 480 


Gln His Phe Thr Phe Glu Leu Ser Pro Ser Tyr Ala His Ala Pro Ser 
                485                 490                 495     


Val Thr Ile Thr Leu His Pro Gln Phe Gly Ala His Phe Ile Leu His 
            500                 505                 510         


Lys Arg 
        


<210>  95
<211>  418
<212>  PRT
<213>  Prunus persica

<400>  95

Met Gly Pro Ile Pro Arg Val His Ile Met Asn Pro Glu Asp Leu Lys 
1               5                   10                  15      


Asp Thr Phe Asn Arg His Asp Asp Phe His Lys Val Val Lys Asn Pro 
            20                  25                  30          


Ile Met Lys Ser Leu Pro Gln Gly Ile Val Gly Ile Glu Gly Asp Gln 
        35                  40                  45              


Trp Ala Lys His Arg Lys Ile Ile Asn Pro Ala Phe His Leu Glu Lys 
    50                  55                  60                  


Leu Lys Gly Met Val Pro Ile Phe Tyr Gln Ser Cys Ser Glu Met Ile 
65                  70                  75                  80  


Asn Ile Trp Lys Ser Leu Val Ser Lys Glu Ser Ser Cys Glu Leu Asp 
                85                  90                  95      


Val Trp Pro Tyr Leu Glu Asn Phe Thr Ser Asp Val Ile Ser Arg Ala 
            100                 105                 110         


Ala Phe Gly Ser Ser Tyr Glu Glu Gly Arg Lys Ile Phe Gln Leu Leu 
        115                 120                 125             


Arg Glu Glu Ala Lys Val Tyr Thr Val Ala Val Arg Ser Val Tyr Ile 
    130                 135                 140                 


Pro Gly Trp Arg Phe Leu Pro Thr Lys Gln Asn Lys Lys Thr Lys Glu 
145                 150                 155                 160 


Ile His Asn Glu Ile Lys Gly Leu Leu Lys Gly Ile Ile Asn Lys Arg 
                165                 170                 175     


Glu Glu Ala Met Lys Ala Gly Glu Ala Thr Lys Asp Asp Leu Leu Gly 
            180                 185                 190         


Ile Leu Met Glu Ser Asn Phe Arg Glu Ile Gln Glu His Gly Asn Asn 
        195                 200                 205             


Lys Asn Ala Gly Met Ser Ile Glu Asp Val Ile Gly Glu Cys Lys Leu 
    210                 215                 220                 


Phe Tyr Phe Ala Gly Gln Glu Thr Thr Ser Val Leu Leu Val Trp Thr 
225                 230                 235                 240 


Met Val Leu Leu Ser Gln Asn Gln Asp Trp Gln Ala Arg Ala Arg Glu 
                245                 250                 255     


Glu Val Leu Gln Val Phe Gly Ser Asn Ile Pro Thr Tyr Glu Glu Leu 
            260                 265                 270         


Ser His Leu Lys Val Val Thr Met Ile Leu Leu Glu Val Leu Arg Leu 
        275                 280                 285             


Tyr Pro Ser Val Val Ala Leu Pro Arg Thr Thr His Lys Lys Thr Gln 
    290                 295                 300                 


Leu Gly Lys Leu Ser Leu Pro Ala Gly Val Glu Val Ser Leu Pro Ile 
305                 310                 315                 320 


Leu Leu Val His His Asp Lys Glu Leu Trp Gly Glu Asp Ala Asn Glu 
                325                 330                 335     


Phe Lys Pro Glu Arg Phe Ser Glu Gly Val Ser Lys Ala Thr Lys Asn 
            340                 345                 350         


Gln Phe Thr Tyr Phe Pro Phe Gly Gly Gly Pro Arg Ile Cys Ile Gly 
        355                 360                 365             


Gln Asn Phe Ala Met Met Glu Ala Lys Leu Ala Leu Ser Leu Ile Leu 
    370                 375                 380                 


Gln His Phe Thr Phe Glu Leu Ser Pro Gln Tyr Ser His Ala Pro Ser 
385                 390                 395                 400 


Val Thr Ile Thr Leu Gln Pro Gln Tyr Gly Ala His Leu Ile Leu His 
                405                 410                 415     


Lys Arg 
        


<210>  96
<211>  1566
<212>  DNA
<213>  Prunus avium

<400>  96
atggaagcat caagggctag ttgtgttgcg ctatgtgttg tttgggtgag catagtaatt       60

acattggcat ggagggtgct gaattgggtg tggttgaggc caaagaaact agaaagatgc      120

ttgagggagc aaggccttac aggcaattct tacaggcttt tgtttggaga caccaaggat      180

ctctcgaaga tgctggaaca aacacaatcc aaacccatca aactctccac ctcccatgat      240

atagcgccac gagtcacccc atttttccat cgaactgtga actctaatgg caagaattct      300

tttgtttgga tgggccctat accaagagtg cacatcatga atccagaaga tttgaaagat      360

gccttcaaca gacatgatga ttttcataag acagtaaaaa atcctatcat gaagtctcca      420

ccaccgggca ttgtaggcat tgaaggtgag caatgggcta aacacagaaa gattatcaac      480

ccagcattcc atttagagaa gctaaagggt atggtaccaa tattttacca aagttgtagc      540

gagatgatta acaaatggga gagcttggtg tccaaagaga gttcatgtga gttggatgtg      600

tggccttatc ttgaaaattt taccagcgat gtgatttccc gagctgcatt tggaagtagc      660

tatgaagagg gaaggaaaat atttcaacta ctaagagagg aagcaaaagt ttattcggta      720

gctctacgaa gtgtttacat tccaggatgg aggtttctac caaccaagca gaacaagaag      780

acgaaggaaa ttcacaatga aattaaaggc ttacttaagg gcattataaa taaaagggaa      840

gaggcgatga aggcagggga agccactaaa gatgacttac taggaatact tatggagtcc      900

aacttcaggg aaattcagga acatgggaac aacaaaaatg ctggaatgag tattgaagat      960

gtaattggag agtgtaagtt gttttacttt gctgggcaag agaccacttc ggtgttgctt     1020

gtttggacaa tgattttact aagccaaaat caggattggc aagctcgtgc aagagaagag     1080

gtcttgaaag tctttggaag caacatccca acctatgaag agctaagtca cctaaaagtt     1140

gtgaccatga ttttacttga agttcttcga ttatacccat cagtcgttgc gcttcctcga     1200

accactcaca agaaaacaca gcttggaaaa ttatcattac cagctggagt ggaagtctcc     1260

ttgcccatac tgcttgttca ccatgacaaa gagttgtggg gtgaggatgc aaatgagttc     1320

aagccagaga ggttttcaga gggagtttca aaggcaacaa agaacaaatt tacatactta     1380

cctttcggag ggggtccaag gatttgcatt ggacaaaact ttgccatggt ggaagctaaa     1440

ttggccttgg ccctgatttt acaacacttt gcctttgagc tttctccatc ctatgctcat     1500

gctccttctg cagttataac ccttcaacct caatttggtg ctcatatcat tttgcataaa     1560

cgttga                                                                1566


<210>  97
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  97
atgtcctcca actccgattt ggtcagaaga ttggaatctg ttttgggtgt ttctttcggt       60

ggttctgtta ctgattccgt tgttgttatt gctaccacct ctattgcttt ggttatcggt      120

gttttggttt tgttgtggag aagatcctct gacagatcta gagaagttaa gcaattggct      180

gttccaaagc cagttactat cgttgaagaa gaagatgaat tcgaagttgc ttctggtaag      240

accagagttt ctattttcta cggtactcaa actggtactg ctgaaggttt tgctaaggct      300

ttggctgaag aaatcaaagc cagatacgaa aaagctgccg ttaaggttat tgatttggat      360

gattacacag ccgaagatga caaatacggt gaaaagttga agaaagaaac tatggccttc      420

ttcatgttgg ctacttatgg tgatggtgaa cctactgata atgctgctag attttacaag      480

tggttcaccg aaggtactga tagaggtgtt tggttggaac atttgagata cggtgtattc      540

ggtttgggta acagacaata cgaacacttc aacaagattg ccaaggttgt tgatgatttg      600

ttggttgaac aaggtgccaa gagattggtt actgttggtt tgggtgatga tgatcaatgc      660

atcgaagatg atttctccgc ttggaaagaa gccttgtggc cagaattgga tcaattattg      720

caagatgata ccaacaccgt ttctactcca tacactgctg ttattccaga atacagagtt      780

gttatccacg atccatctgt tacctcttat gaagatccat actctaacat ggctaacggt      840

aatgcctctt acgatattca tcatccatgt agagctaacg ttgccgtcca aaaagaattg      900

cataagccag aatctgacag aagttgcatc catttggaat tcgatatttt cgctactggt      960

ttgacttacg aaaccggtga tcatgttggt gtttacgctg ataattgtga tgatactgta     1020

gaagaagccg ctaagttgtt gggtcaacca ttggatttgt tgttctccat tcataccgat     1080

aacaacgacg gtacttcttt gggttcttct ttgccaccac catttccagg tccatgtact     1140

ttgagaactg ctttggctag atatgccgat ttgttgaatc caccaaaaaa ggctgctttg     1200

attgctttag ctgctcatgc tgatgaacca tctgaagctg aaagattgaa gttcttgtca     1260

tctccacaag gtaaggacga atattctaaa tgggttgtcg gttcccaaag atccttggtt     1320

gaagttatgg ctgaatttcc atctgctaaa ccaccattgg gtgtattttt tgctgctgtt     1380

gttcctagat tgcaacctag atattactcc atctcttcca gtccaagatt tgctccacat     1440

agagttcatg ttacttgcgc tttggtttat ggtccaactc caactggtag aattcacaga     1500

ggtgtatgtt cattctggat gaagaatgtt gtcccattgg aaaagtctca aaactgttct     1560

tgggccccaa ttttcatcag acaatctaat ttcaagttgc cagccgatca ttctgttcca     1620

atagttatgg ttggtccagg tactggttta gctcctttta gaggtttctt acaagaaaga     1680

ttggccttga aagaagaagg tgctcaagtt ggtcctgctt tgttgttttt tggttgcaga     1740

aacagacaaa tggacttcat ctacgaagtc gaattgaaca actttgtcga acaaggtgct     1800

ttgtccgaat tgatcgttgc tttttcaaga gaaggtccat ccaaagaata cgtccaacat     1860

aagatggttg aaaaggcagc ttacatgtgg aacttgattt ctcaaggtgg ttacttctac     1920

gtttgtggtg atgctaaagg tatggctaga gatgttcata gaacattgca taccatcgtc     1980

caacaagaag aaaaggttga ttctaccaag gccgaatcca tcgttaagaa attgcaaatg     2040

gacggtagat acttgagaga tgtttggtga                                      2070


<210>  98
<211>  689
<212>  PRT
<213>  Rubus suavissimus

<400>  98

Met Ser Ser Asn Ser Asp Leu Val Arg Arg Leu Glu Ser Val Leu Gly 
1               5                   10                  15      


Val Ser Phe Gly Gly Ser Val Thr Asp Ser Val Val Val Ile Ala Thr 
            20                  25                  30          


Thr Ser Ile Ala Leu Val Ile Gly Val Leu Val Leu Leu Trp Arg Arg 
        35                  40                  45              


Ser Ser Asp Arg Ser Arg Glu Val Lys Gln Leu Ala Val Pro Lys Pro 
    50                  55                  60                  


Val Thr Ile Val Glu Glu Glu Asp Glu Phe Glu Val Ala Ser Gly Lys 
65                  70                  75                  80  


Thr Arg Val Ser Ile Phe Tyr Gly Thr Gln Thr Gly Thr Ala Glu Gly 
                85                  90                  95      


Phe Ala Lys Ala Leu Ala Glu Glu Ile Lys Ala Arg Tyr Glu Lys Ala 
            100                 105                 110         


Ala Val Lys Val Ile Asp Leu Asp Asp Tyr Thr Ala Glu Asp Asp Lys 
        115                 120                 125             


Tyr Gly Glu Lys Leu Lys Lys Glu Thr Met Ala Phe Phe Met Leu Ala 
    130                 135                 140                 


Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala Ala Arg Phe Tyr Lys 
145                 150                 155                 160 


Trp Phe Thr Glu Gly Thr Asp Arg Gly Val Trp Leu Glu His Leu Arg 
                165                 170                 175     


Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln Tyr Glu His Phe Asn Lys 
            180                 185                 190         


Ile Ala Lys Val Val Asp Asp Leu Leu Val Glu Gln Gly Ala Lys Arg 
        195                 200                 205             


Leu Val Thr Val Gly Leu Gly Asp Asp Asp Gln Cys Ile Glu Asp Asp 
    210                 215                 220                 


Phe Ser Ala Trp Lys Glu Ala Leu Trp Pro Glu Leu Asp Gln Leu Leu 
225                 230                 235                 240 


Gln Asp Asp Thr Asn Thr Val Ser Thr Pro Tyr Thr Ala Val Ile Pro 
                245                 250                 255     


Glu Tyr Arg Val Val Ile His Asp Pro Ser Val Thr Ser Tyr Glu Asp 
            260                 265                 270         


Pro Tyr Ser Asn Met Ala Asn Gly Asn Ala Ser Tyr Asp Ile His His 
        275                 280                 285             


Pro Cys Arg Ala Asn Val Ala Val Gln Lys Glu Leu His Lys Pro Glu 
    290                 295                 300                 


Ser Asp Arg Ser Cys Ile His Leu Glu Phe Asp Ile Phe Ala Thr Gly 
305                 310                 315                 320 


Leu Thr Tyr Glu Thr Gly Asp His Val Gly Val Tyr Ala Asp Asn Cys 
                325                 330                 335     


Asp Asp Thr Val Glu Glu Ala Ala Lys Leu Leu Gly Gln Pro Leu Asp 
            340                 345                 350         


Leu Leu Phe Ser Ile His Thr Asp Asn Asn Asp Gly Thr Ser Leu Gly 
        355                 360                 365             


Ser Ser Leu Pro Pro Pro Phe Pro Gly Pro Cys Thr Leu Arg Thr Ala 
    370                 375                 380                 


Leu Ala Arg Tyr Ala Asp Leu Leu Asn Pro Pro Lys Lys Ala Ala Leu 
385                 390                 395                 400 


Ile Ala Leu Ala Ala His Ala Asp Glu Pro Ser Glu Ala Glu Arg Leu 
                405                 410                 415     


Lys Phe Leu Ser Ser Pro Gln Gly Lys Asp Glu Tyr Ser Lys Trp Val 
            420                 425                 430         


Val Gly Ser Gln Arg Ser Leu Val Glu Val Met Ala Glu Phe Pro Ser 
        435                 440                 445             


Ala Lys Pro Pro Leu Gly Val Phe Phe Ala Ala Val Val Pro Arg Leu 
    450                 455                 460                 


Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Phe Ala Pro His 
465                 470                 475                 480 


Arg Val His Val Thr Cys Ala Leu Val Tyr Gly Pro Thr Pro Thr Gly 
                485                 490                 495     


Arg Ile His Arg Gly Val Cys Ser Phe Trp Met Lys Asn Val Val Pro 
            500                 505                 510         


Leu Glu Lys Ser Gln Asn Cys Ser Trp Ala Pro Ile Phe Ile Arg Gln 
        515                 520                 525             


Ser Asn Phe Lys Leu Pro Ala Asp His Ser Val Pro Ile Val Met Val 
    530                 535                 540                 


Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe Leu Gln Glu Arg 
545                 550                 555                 560 


Leu Ala Leu Lys Glu Glu Gly Ala Gln Val Gly Pro Ala Leu Leu Phe 
                565                 570                 575     


Phe Gly Cys Arg Asn Arg Gln Met Asp Phe Ile Tyr Glu Val Glu Leu 
            580                 585                 590         


Asn Asn Phe Val Glu Gln Gly Ala Leu Ser Glu Leu Ile Val Ala Phe 
        595                 600                 605             


Ser Arg Glu Gly Pro Ser Lys Glu Tyr Val Gln His Lys Met Val Glu 
    610                 615                 620                 


Lys Ala Ala Tyr Met Trp Asn Leu Ile Ser Gln Gly Gly Tyr Phe Tyr 
625                 630                 635                 640 


Val Cys Gly Asp Ala Lys Gly Met Ala Arg Asp Val His Arg Thr Leu 
                645                 650                 655     


His Thr Ile Val Gln Gln Glu Glu Lys Val Asp Ser Thr Lys Ala Glu 
            660                 665                 670         


Ser Ile Val Lys Lys Leu Gln Met Asp Gly Arg Tyr Leu Arg Asp Val 
        675                 680                 685             


Trp 
    


<210>  99
<211>  3315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  99
atggatgctg tgacgggttt gttaactgtc ccagcaaccg ctataactat tggtggaact       60

gctgtagcat tggcggtagc gctaatcttt tggtacctga aatcctacac atcagctaga      120

agatcccaat caaatcatct tccaagagtg cctgaagtcc caggtgttcc attgttagga      180

aatctgttac aattgaagga gaaaaagcca tacatgactt ttacgagatg ggcagcgaca      240

tatggaccta tctatagtat caaaactggg gctacaagta tggttgtggt atcatctaat      300

gagatagcca aggaggcatt ggtgaccaga ttccaatcca tatctacaag gaacttatct      360

aaagccctga aagtacttac agcagataag acaatggtcg caatgtcaga ttatgatgat      420

tatcataaaa cagttaagag acacatactg accgccgtct tgggtcctaa tgcacagaaa      480

aagcatagaa ttcacagaga tatcatgatg gataacatat ctactcaact tcatgaattc      540

gtgaaaaaca acccagaaca ggaagaggta gaccttagaa aaatctttca atctgagtta      600

ttcggcttag ctatgagaca agccttagga aaggatgttg aaagtttgta cgttgaagac      660

ctgaaaatca ctatgaatag agacgaaatc tttcaagtcc ttgttgttga tccaatgatg      720

ggagcaatcg atgttgattg gagagacttc tttccatacc taaagtgggt cccaaacaaa      780

aagttcgaaa atactattca acaaatgtac atcagaagag aagctgttat gaaatcttta      840

atcaaagagc acaaaaagag aatagcgtca ggcgaaaagc taaatagtta tatcgattac      900

cttttatctg aagctcaaac tttaaccgat cagcaactat tgatgtcctt gtgggaacca      960

atcattgaat cttcagatac aacaatggtc acaacagaat gggcaatgta cgaattagct     1020

aaaaacccta aattgcaaga taggttgtac agagacatta agtccgtctg tggatctgaa     1080

aagataaccg aagagcatct atcacagctg ccttacatta cagctatttt ccacgaaaca     1140

ctgagaagac actcaccagt tcctatcatt cctctaagac atgtacatga agataccgtt     1200

ctaggcggct accatgttcc tgctggcaca gaacttgccg ttaacatcta cggttgcaac     1260

atggacaaaa acgtttggga aaatccagag gaatggaacc cagaaagatt catgaaagag     1320

aatgagacaa ttgattttca aaagacgatg gccttcggtg gtggtaagag agtttgtgct     1380

ggttccttgc aagccctttt aactgcatct attgggattg ggagaatggt tcaagagttc     1440

gaatggaaac tgaaggatat gactcaagag gaagtgaaca cgataggcct aactacacaa     1500

atgttaagac cattgagagc tattatcaaa cctaggatcc catcaagacc aagtcctagt     1560

accgaacaat ctgcaaaaaa agttagaaaa aaagcagaaa atgcacacaa tactccattg     1620

ctagttcttt atggttctaa tatgggaaca gcggaaggaa cggccaggga tctagctgac     1680

atagctatgt ccaagggatt tgccccgcaa gtagcaaccc tggattccca tgcaggtaac     1740

ttgccaagag aaggtgctgt tctaatagtt accgctagct acaatgggca ccctccagat     1800

aatgcgaagc agttcgtcga ttggttagat caagcatcag cagatgaagt taagggtgtt     1860

agatactctg tttttggatg tggagataag aattgggcca ccacatatca gaaggttccg     1920

gctttcatcg atgaaatgct tgctgcaaaa ggggctgaaa atatagcaga tcgtggtgag     1980

gccgacgcaa gcgacgattt tgagggtacc tatgaggagt ggagagagca catgtggtct     2040

gatgttgccg cgtattttaa tctagacata gaaaattctg aagacaataa aagtgcctta     2100

cttcttcaat tcgtcgatag tgctgcggac atgcccttag caaagatgca tggagccttt     2160

tcaacgaacg tagtagccag taaggaactt caacaaccag gtagtgccag aagtacacgt     2220

cacttggaaa ttgaattacc aaaagaggca tcctaccaag aaggtgacca tcttggtgta     2280

atcccaagaa actacgaagg tatagtcaat agggtaacgg caagatttgg gctggatgca     2340

agccaacaga taagactaga agcagaagaa gaaaaattgg cgcaccttcc actagcgaag     2400

acagtatccg ttgaagaatt attgcaatac gtggaattgc aggatcccgt cactagaacg     2460

caattgagag ctatggcagc aaagactgtt tgtccacctc acaaggttga acttgaagct     2520

ctacttgaaa aacaagcata caaagagcaa gtgctagcaa agagactaac catgttagaa     2580

ttgctggaaa aatacccggc atgcgaaatg gaattctccg aatttatcgc gttgttgcca     2640

agtattcgtc ccaggtatta ctcaatttca tcttcaccaa gggttgacga gaaacaggca     2700

tctattaccg tatctgtggt ctctggagaa gcttggagtg gttacggaga atacaagggt     2760

attgcttcca attatcttgc agaactgcag gaaggggata caattacctg ctttatttct     2820

actcctcaat cagaatttac tcttccgaag gatccagaaa ctccgttaat tatggtaggt     2880

ccgggaacag gagtcgcccc tttcagaggc tttgtgcaag caaggaagca actaaaagaa     2940

cagggacaaa gtctgggtga ggcacatcta tatttcggtt gcagatctcc gcatgaggat     3000

tacttatacc aagaagaact tgaaaacgcc caatcagaag gtattatcac cttgcatact     3060

gcattcagta gaatgccaaa ccagccgaaa acttacgtac agcatgttat ggagcaagat     3120

ggtaagaagt taattgagct tttggataag ggcgcccact tctacatttg cggcgacgga     3180

tcccaaatgg cgcctgccgt tgaagccacc ttgatgaaat catatgcaga tgttcatcaa     3240

gtttcagaag cggacgcccg tctttggtta caacaactag aggagaaagg aaggtatgca     3300

aaagatgttt ggtaa                                                      3315


<210>  100
<211>  1104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  100

Met Asp Ala Val Thr Gly Leu Leu Thr Val Pro Ala Thr Ala Ile Thr 
1               5                   10                  15      


Ile Gly Gly Thr Ala Val Ala Leu Ala Val Ala Leu Ile Phe Trp Tyr 
            20                  25                  30          


Leu Lys Ser Tyr Thr Ser Ala Arg Arg Ser Gln Ser Asn His Leu Pro 
        35                  40                  45              


Arg Val Pro Glu Val Pro Gly Val Pro Leu Leu Gly Asn Leu Leu Gln 
    50                  55                  60                  


Leu Lys Glu Lys Lys Pro Tyr Met Thr Phe Thr Arg Trp Ala Ala Thr 
65                  70                  75                  80  


Tyr Gly Pro Ile Tyr Ser Ile Lys Thr Gly Ala Thr Ser Met Val Val 
                85                  90                  95      


Val Ser Ser Asn Glu Ile Ala Lys Glu Ala Leu Val Thr Arg Phe Gln 
            100                 105                 110         


Ser Ile Ser Thr Arg Asn Leu Ser Lys Ala Leu Lys Val Leu Thr Ala 
        115                 120                 125             


Asp Lys Thr Met Val Ala Met Ser Asp Tyr Asp Asp Tyr His Lys Thr 
    130                 135                 140                 


Val Lys Arg His Ile Leu Thr Ala Val Leu Gly Pro Asn Ala Gln Lys 
145                 150                 155                 160 


Lys His Arg Ile His Arg Asp Ile Met Met Asp Asn Ile Ser Thr Gln 
                165                 170                 175     


Leu His Glu Phe Val Lys Asn Asn Pro Glu Gln Glu Glu Val Asp Leu 
            180                 185                 190         


Arg Lys Ile Phe Gln Ser Glu Leu Phe Gly Leu Ala Met Arg Gln Ala 
        195                 200                 205             


Leu Gly Lys Asp Val Glu Ser Leu Tyr Val Glu Asp Leu Lys Ile Thr 
    210                 215                 220                 


Met Asn Arg Asp Glu Ile Phe Gln Val Leu Val Val Asp Pro Met Met 
225                 230                 235                 240 


Gly Ala Ile Asp Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Lys Trp 
                245                 250                 255     


Val Pro Asn Lys Lys Phe Glu Asn Thr Ile Gln Gln Met Tyr Ile Arg 
            260                 265                 270         


Arg Glu Ala Val Met Lys Ser Leu Ile Lys Glu His Lys Lys Arg Ile 
        275                 280                 285             


Ala Ser Gly Glu Lys Leu Asn Ser Tyr Ile Asp Tyr Leu Leu Ser Glu 
    290                 295                 300                 


Ala Gln Thr Leu Thr Asp Gln Gln Leu Leu Met Ser Leu Trp Glu Pro 
305                 310                 315                 320 


Ile Ile Glu Ser Ser Asp Thr Thr Met Val Thr Thr Glu Trp Ala Met 
                325                 330                 335     


Tyr Glu Leu Ala Lys Asn Pro Lys Leu Gln Asp Arg Leu Tyr Arg Asp 
            340                 345                 350         


Ile Lys Ser Val Cys Gly Ser Glu Lys Ile Thr Glu Glu His Leu Ser 
        355                 360                 365             


Gln Leu Pro Tyr Ile Thr Ala Ile Phe His Glu Thr Leu Arg Arg His 
    370                 375                 380                 


Ser Pro Val Pro Ile Ile Pro Leu Arg His Val His Glu Asp Thr Val 
385                 390                 395                 400 


Leu Gly Gly Tyr His Val Pro Ala Gly Thr Glu Leu Ala Val Asn Ile 
                405                 410                 415     


Tyr Gly Cys Asn Met Asp Lys Asn Val Trp Glu Asn Pro Glu Glu Trp 
            420                 425                 430         


Asn Pro Glu Arg Phe Met Lys Glu Asn Glu Thr Ile Asp Phe Gln Lys 
        435                 440                 445             


Thr Met Ala Phe Gly Gly Gly Lys Arg Val Cys Ala Gly Ser Leu Gln 
    450                 455                 460                 


Ala Leu Leu Thr Ala Ser Ile Gly Ile Gly Arg Met Val Gln Glu Phe 
465                 470                 475                 480 


Glu Trp Lys Leu Lys Asp Met Thr Gln Glu Glu Val Asn Thr Ile Gly 
                485                 490                 495     


Leu Thr Thr Gln Met Leu Arg Pro Leu Arg Ala Ile Ile Lys Pro Arg 
            500                 505                 510         


Ile Pro Ser Arg Pro Ser Pro Ser Thr Glu Gln Ser Ala Lys Lys Val 
        515                 520                 525             


Arg Lys Lys Ala Glu Asn Ala His Asn Thr Pro Leu Leu Val Leu Tyr 
    530                 535                 540                 


Gly Ser Asn Met Gly Thr Ala Glu Gly Thr Ala Arg Asp Leu Ala Asp 
545                 550                 555                 560 


Ile Ala Met Ser Lys Gly Phe Ala Pro Gln Val Ala Thr Leu Asp Ser 
                565                 570                 575     


His Ala Gly Asn Leu Pro Arg Glu Gly Ala Val Leu Ile Val Thr Ala 
            580                 585                 590         


Ser Tyr Asn Gly His Pro Pro Asp Asn Ala Lys Gln Phe Val Asp Trp 
        595                 600                 605             


Leu Asp Gln Ala Ser Ala Asp Glu Val Lys Gly Val Arg Tyr Ser Val 
    610                 615                 620                 


Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr Thr Tyr Gln Lys Val Pro 
625                 630                 635                 640 


Ala Phe Ile Asp Glu Met Leu Ala Ala Lys Gly Ala Glu Asn Ile Ala 
                645                 650                 655     


Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp Phe Glu Gly Thr Tyr Glu 
            660                 665                 670         


Glu Trp Arg Glu His Met Trp Ser Asp Val Ala Ala Tyr Phe Asn Leu 
        675                 680                 685             


Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser Ala Leu Leu Leu Gln Phe 
    690                 695                 700                 


Val Asp Ser Ala Ala Asp Met Pro Leu Ala Lys Met His Gly Ala Phe 
705                 710                 715                 720 


Ser Thr Asn Val Val Ala Ser Lys Glu Leu Gln Gln Pro Gly Ser Ala 
                725                 730                 735     


Arg Ser Thr Arg His Leu Glu Ile Glu Leu Pro Lys Glu Ala Ser Tyr 
            740                 745                 750         


Gln Glu Gly Asp His Leu Gly Val Ile Pro Arg Asn Tyr Glu Gly Ile 
        755                 760                 765             


Val Asn Arg Val Thr Ala Arg Phe Gly Leu Asp Ala Ser Gln Gln Ile 
    770                 775                 780                 


Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala His Leu Pro Leu Ala Lys 
785                 790                 795                 800 


Thr Val Ser Val Glu Glu Leu Leu Gln Tyr Val Glu Leu Gln Asp Pro 
                805                 810                 815     


Val Thr Arg Thr Gln Leu Arg Ala Met Ala Ala Lys Thr Val Cys Pro 
            820                 825                 830         


Pro His Lys Val Glu Leu Glu Ala Leu Leu Glu Lys Gln Ala Tyr Lys 
        835                 840                 845             


Glu Gln Val Leu Ala Lys Arg Leu Thr Met Leu Glu Leu Leu Glu Lys 
    850                 855                 860                 


Tyr Pro Ala Cys Glu Met Glu Phe Ser Glu Phe Ile Ala Leu Leu Pro 
865                 870                 875                 880 


Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Val Asp 
                885                 890                 895     


Glu Lys Gln Ala Ser Ile Thr Val Ser Val Val Ser Gly Glu Ala Trp 
            900                 905                 910         


Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala Ser Asn Tyr Leu Ala Glu 
        915                 920                 925             


Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe Ile Ser Thr Pro Gln Ser 
    930                 935                 940                 


Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr Pro Leu Ile Met Val Gly 
945                 950                 955                 960 


Pro Gly Thr Gly Val Ala Pro Phe Arg Gly Phe Val Gln Ala Arg Lys 
                965                 970                 975     


Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly Glu Ala His Leu Tyr Phe 
            980                 985                 990         


Gly Cys Arg Ser Pro His Glu Asp  Tyr Leu Tyr Gln Glu  Glu Leu Glu 
        995                 1000                 1005             


Asn Ala  Gln Ser Glu Gly Ile  Ile Thr Leu His Thr  Ala Phe Ser 
    1010                 1015                 1020             


Arg Met  Pro Asn Gln Pro Lys  Thr Tyr Val Gln His  Val Met Glu 
    1025                 1030                 1035             


Gln Asp  Gly Lys Lys Leu Ile  Glu Leu Leu Asp Lys  Gly Ala His 
    1040                 1045                 1050             


Phe Tyr  Ile Cys Gly Asp Gly  Ser Gln Met Ala Pro  Ala Val Glu 
    1055                 1060                 1065             


Ala Thr  Leu Met Lys Ser Tyr  Ala Asp Val His Gln  Val Ser Glu 
    1070                 1075                 1080             


Ala Asp  Ala Arg Leu Trp Leu  Gln Gln Leu Glu Glu  Lys Gly Arg 
    1085                 1090                 1095             


Tyr Ala  Lys Asp Val Trp 
    1100                 


<210>  101
<211>  3315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  101
atggatgctg tgacgggttt gttaactgtc ccagcaaccg ctataactat tggtggaact       60

gctgtagcat tggcggtagc gctaatcttt tggtacctga aatcctacac atcagctaga      120

agatcccaat caaatcatct tccaagagtg cctgaagtcc caggtgttcc attgttagga      180

aatctgttac aattgaagga gaaaaagcca tacatgactt ttacgagatg ggcagcgaca      240

tatggaccta tctatagtat caaaactggg gctacaagta tggttgtggt atcatctaat      300

gagatagcca aggaggcatt ggtgaccaga ttccaatcca tatctacaag gaacttatct      360

aaagccctga aagtacttac agcagataag acaatggtcg caatgtcaga ttatgatgat      420

tatcataaaa cagttaagag acacatactg accgccgtct tgggtcctaa tgcacagaaa      480

aagcatagaa ttcacagaga tatcatgatg gataacatat ctactcaact tcatgaattc      540

gtgaaaaaca acccagaaca ggaagaggta gaccttagaa aaatctttca atctgagtta      600

ttcggcttag ctatgagaca agccttagga aaggatgttg aaagtttgta cgttgaagac      660

ctgaaaatca ctatgaatag agacgaaatc tttcaagtcc ttgttgttga tccaatgatg      720

ggagcaatcg atgttgattg gagagacttc tttccatacc taaagtgggt cccaaacaaa      780

aagttcgaaa atactattca acaaatgtac atcagaagag aagctgttat gaaatcttta      840

atcaaagagc acaaaaagag aatagcgtca ggcgaaaagc taaatagtta tatcgattac      900

cttttatctg aagctcaaac tttaaccgat cagcaactat tgatgtcctt gtgggaacca      960

atcattgaat cttcagatac aacaatggtc acaacagaat gggcaatgta cgaattagct     1020

aaaaacccta aattgcaaga taggttgtac agagacatta agtccgtctg tggatctgaa     1080

aagataaccg aagagcatct atcacagctg ccttacatta cagctatttt ccacgaaaca     1140

ctgagaagac actcaccagt tcctatcatt cctctaagac atgtacatga agataccgtt     1200

ctaggcggct accatgttcc tgctggcaca gaacttgccg ttaacatcta cggttgcaac     1260

atggacaaaa acgtttggga aaatccagag gaatggaacc cagaaagatt catgaaagag     1320

aatgagacaa ttgattttca aaagacgatg gccttcggtg gtggtaagag agtttgtgct     1380

ggttccttgc aagccctttt aactgcatct attgggattg ggagaatggt tcaagagttc     1440

gaatggaaac tgaaggatat gactcaagag gaagtgaaca cgataggcct aactacacaa     1500

atgttaagac cattgagagc tattatcaaa cctaggatcc catcaagacc aagtcctagt     1560

accgaacaat ctgcaaaaaa agttagaaaa aaagcagaaa atgcacacaa tactccattg     1620

ctagttcttt atggttctaa tatgggaaca gcggaaggaa cggccaggga tctagctgac     1680

atagctatgt ccaagggatt tgccccgcaa gtagcaaccc tggattccca tgcaggtaac     1740

ttgccaagag aaggtgctgt tctaatagtt accgctagct acaatgggca ccctccagat     1800

aatgcgaagc agttcgtcga ttggttagat caagcatcag cagatgaagt taagggtgtt     1860

agatactctg tttttggatg tggagataag aattgggcca ccacatatca gaaggttccg     1920

gctttcatcg atgaaatgct tgctgcaaaa ggggctgaaa atatagcaga tcgtggtgag     1980

gccgacgcaa gcgacgattt tgagggtacc tatgaggagt ggagagagca catgtggtct     2040

gatgttgccg cgtattttaa tctagacata gaaaattctg aagacaataa aagtgcctta     2100

cttcttcaat tcgtcgatag tgctgcggac atgcccttag caaagatgca tggagccttt     2160

tcaacgaacg tagtagccag taaggaactt caacaaccag gtagtgccag aagtacacgt     2220

cacttggaaa ttgaattacc aaaagaggca tcctaccaag aaggtgacca tcttggtgta     2280

atcccaagaa actacgaagg tatagtcaat agggtaacgg caagatttgg gctggatgca     2340

agccaacaga taagactaga agcagaagaa gaaaaattgg cgcaccttcc actagcgaag     2400

acagtatccg ttgaagaatt attgcaatac gtggaattgc aggatcccgt cactagaacg     2460

caattgagag ctatggcagc aaagactgtt tgtccacctc acaaggttga acttgaagct     2520

ctacttgaaa aacaagcata caaagagcaa gtgctagcaa agagactaac catgttagaa     2580

ttgctggaaa aatacccggc atgcgaaatg gaattctccg aatttatcgc gttgttgcca     2640

agtattcgtc ccaggtatta ctcaatttca tcttcaccaa gggttgacga gaaacaggca     2700

tctattaccg tatctgtggt ctctggagaa gcttggagtg gttacggaga atacaagggt     2760

attgcttcca attatcttgc agaactgcag gaaggggata caattacctg ctttatttct     2820

actcctcaat cagaatttac tcttccgaag gatccagaaa ctccgttaat tatggtaggt     2880

ccgggaacag gagtcgcccc tttcagaggc tttgtgcaag caaggaagca actaaaagaa     2940

cagggacaaa gtctgggtga ggcacatcta tatttcggtt gcagatctcc gcatgaggat     3000

tacttatacc aagaagaact tgaaaacgcc caatcagaag gtattatcac cttgcatact     3060

gcattcagta gaatgccaaa ccagccgaaa acttacgtac agcatgttat ggagcaagat     3120

ggtaagaagt taattgagct tttggataag ggcgcccact tctacatttg cggcgacgga     3180

tcccaaatgg cgcctgccgt tgaagccacc ttgatgaaat catatgcaga tgttcatcaa     3240

gtttcagaag cggacgcccg tctttggtta caacaactag aggagaaagg aaggtatgca     3300

aaagatgttg cttaa                                                      3315


<210>  102
<211>  1104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  102

Met Asp Ala Val Thr Gly Leu Leu Thr Val Pro Ala Thr Ala Ile Thr 
1               5                   10                  15      


Ile Gly Gly Thr Ala Val Ala Leu Ala Val Ala Leu Ile Phe Trp Tyr 
            20                  25                  30          


Leu Lys Ser Tyr Thr Ser Ala Arg Arg Ser Gln Ser Asn His Leu Pro 
        35                  40                  45              


Arg Val Pro Glu Val Pro Gly Val Pro Leu Leu Gly Asn Leu Leu Gln 
    50                  55                  60                  


Leu Lys Glu Lys Lys Pro Tyr Met Thr Phe Thr Arg Trp Ala Ala Thr 
65                  70                  75                  80  


Tyr Gly Pro Ile Tyr Ser Ile Lys Thr Gly Ala Thr Ser Met Val Val 
                85                  90                  95      


Val Ser Ser Asn Glu Ile Ala Lys Glu Ala Leu Val Thr Arg Phe Gln 
            100                 105                 110         


Ser Ile Ser Thr Arg Asn Leu Ser Lys Ala Leu Lys Val Leu Thr Ala 
        115                 120                 125             


Asp Lys Thr Met Val Ala Met Ser Asp Tyr Asp Asp Tyr His Lys Thr 
    130                 135                 140                 


Val Lys Arg His Ile Leu Thr Ala Val Leu Gly Pro Asn Ala Gln Lys 
145                 150                 155                 160 


Lys His Arg Ile His Arg Asp Ile Met Met Asp Asn Ile Ser Thr Gln 
                165                 170                 175     


Leu His Glu Phe Val Lys Asn Asn Pro Glu Gln Glu Glu Val Asp Leu 
            180                 185                 190         


Arg Lys Ile Phe Gln Ser Glu Leu Phe Gly Leu Ala Met Arg Gln Ala 
        195                 200                 205             


Leu Gly Lys Asp Val Glu Ser Leu Tyr Val Glu Asp Leu Lys Ile Thr 
    210                 215                 220                 


Met Asn Arg Asp Glu Ile Phe Gln Val Leu Val Val Asp Pro Met Met 
225                 230                 235                 240 


Gly Ala Ile Asp Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Lys Trp 
                245                 250                 255     


Val Pro Asn Lys Lys Phe Glu Asn Thr Ile Gln Gln Met Tyr Ile Arg 
            260                 265                 270         


Arg Glu Ala Val Met Lys Ser Leu Ile Lys Glu His Lys Lys Arg Ile 
        275                 280                 285             


Ala Ser Gly Glu Lys Leu Asn Ser Tyr Ile Asp Tyr Leu Leu Ser Glu 
    290                 295                 300                 


Ala Gln Thr Leu Thr Asp Gln Gln Leu Leu Met Ser Leu Trp Glu Pro 
305                 310                 315                 320 


Ile Ile Glu Ser Ser Asp Thr Thr Met Val Thr Thr Glu Trp Ala Met 
                325                 330                 335     


Tyr Glu Leu Ala Lys Asn Pro Lys Leu Gln Asp Arg Leu Tyr Arg Asp 
            340                 345                 350         


Ile Lys Ser Val Cys Gly Ser Glu Lys Ile Thr Glu Glu His Leu Ser 
        355                 360                 365             


Gln Leu Pro Tyr Ile Thr Ala Ile Phe His Glu Thr Leu Arg Arg His 
    370                 375                 380                 


Ser Pro Val Pro Ile Ile Pro Leu Arg His Val His Glu Asp Thr Val 
385                 390                 395                 400 


Leu Gly Gly Tyr His Val Pro Ala Gly Thr Glu Leu Ala Val Asn Ile 
                405                 410                 415     


Tyr Gly Cys Asn Met Asp Lys Asn Val Trp Glu Asn Pro Glu Glu Trp 
            420                 425                 430         


Asn Pro Glu Arg Phe Met Lys Glu Asn Glu Thr Ile Asp Phe Gln Lys 
        435                 440                 445             


Thr Met Ala Phe Gly Gly Gly Lys Arg Val Cys Ala Gly Ser Leu Gln 
    450                 455                 460                 


Ala Leu Leu Thr Ala Ser Ile Gly Ile Gly Arg Met Val Gln Glu Phe 
465                 470                 475                 480 


Glu Trp Lys Leu Lys Asp Met Thr Gln Glu Glu Val Asn Thr Ile Gly 
                485                 490                 495     


Leu Thr Thr Gln Met Leu Arg Pro Leu Arg Ala Ile Ile Lys Pro Arg 
            500                 505                 510         


Ile Pro Ser Arg Pro Ser Pro Ser Thr Glu Gln Ser Ala Lys Lys Val 
        515                 520                 525             


Arg Lys Lys Ala Glu Asn Ala His Asn Thr Pro Leu Leu Val Leu Tyr 
    530                 535                 540                 


Gly Ser Asn Met Gly Thr Ala Glu Gly Thr Ala Arg Asp Leu Ala Asp 
545                 550                 555                 560 


Ile Ala Met Ser Lys Gly Phe Ala Pro Gln Val Ala Thr Leu Asp Ser 
                565                 570                 575     


His Ala Gly Asn Leu Pro Arg Glu Gly Ala Val Leu Ile Val Thr Ala 
            580                 585                 590         


Ser Tyr Asn Gly His Pro Pro Asp Asn Ala Lys Gln Phe Val Asp Trp 
        595                 600                 605             


Leu Asp Gln Ala Ser Ala Asp Glu Val Lys Gly Val Arg Tyr Ser Val 
    610                 615                 620                 


Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr Thr Tyr Gln Lys Val Pro 
625                 630                 635                 640 


Ala Phe Ile Asp Glu Met Leu Ala Ala Lys Gly Ala Glu Asn Ile Ala 
                645                 650                 655     


Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp Phe Glu Gly Thr Tyr Glu 
            660                 665                 670         


Glu Trp Arg Glu His Met Trp Ser Asp Val Ala Ala Tyr Phe Asn Leu 
        675                 680                 685             


Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser Ala Leu Leu Leu Gln Phe 
    690                 695                 700                 


Val Asp Ser Ala Ala Asp Met Pro Leu Ala Lys Met His Gly Ala Phe 
705                 710                 715                 720 


Ser Thr Asn Val Val Ala Ser Lys Glu Leu Gln Gln Pro Gly Ser Ala 
                725                 730                 735     


Arg Ser Thr Arg His Leu Glu Ile Glu Leu Pro Lys Glu Ala Ser Tyr 
            740                 745                 750         


Gln Glu Gly Asp His Leu Gly Val Ile Pro Arg Asn Tyr Glu Gly Ile 
        755                 760                 765             


Val Asn Arg Val Thr Ala Arg Phe Gly Leu Asp Ala Ser Gln Gln Ile 
    770                 775                 780                 


Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala His Leu Pro Leu Ala Lys 
785                 790                 795                 800 


Thr Val Ser Val Glu Glu Leu Leu Gln Tyr Val Glu Leu Gln Asp Pro 
                805                 810                 815     


Val Thr Arg Thr Gln Leu Arg Ala Met Ala Ala Lys Thr Val Cys Pro 
            820                 825                 830         


Pro His Lys Val Glu Leu Glu Ala Leu Leu Glu Lys Gln Ala Tyr Lys 
        835                 840                 845             


Glu Gln Val Leu Ala Lys Arg Leu Thr Met Leu Glu Leu Leu Glu Lys 
    850                 855                 860                 


Tyr Pro Ala Cys Glu Met Glu Phe Ser Glu Phe Ile Ala Leu Leu Pro 
865                 870                 875                 880 


Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Val Asp 
                885                 890                 895     


Glu Lys Gln Ala Ser Ile Thr Val Ser Val Val Ser Gly Glu Ala Trp 
            900                 905                 910         


Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala Ser Asn Tyr Leu Ala Glu 
        915                 920                 925             


Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe Ile Ser Thr Pro Gln Ser 
    930                 935                 940                 


Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr Pro Leu Ile Met Val Gly 
945                 950                 955                 960 


Pro Gly Thr Gly Val Ala Pro Phe Arg Gly Phe Val Gln Ala Arg Lys 
                965                 970                 975     


Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly Glu Ala His Leu Tyr Phe 
            980                 985                 990         


Gly Cys Arg Ser Pro His Glu Asp  Tyr Leu Tyr Gln Glu  Glu Leu Glu 
        995                 1000                 1005             


Asn Ala  Gln Ser Glu Gly Ile  Ile Thr Leu His Thr  Ala Phe Ser 
    1010                 1015                 1020             


Arg Met  Pro Asn Gln Pro Lys  Thr Tyr Val Gln His  Val Met Glu 
    1025                 1030                 1035             


Gln Asp  Gly Lys Lys Leu Ile  Glu Leu Leu Asp Lys  Gly Ala His 
    1040                 1045                 1050             


Phe Tyr  Ile Cys Gly Asp Gly  Ser Gln Met Ala Pro  Ala Val Glu 
    1055                 1060                 1065             


Ala Thr  Leu Met Lys Ser Tyr  Ala Asp Val His Gln  Val Ser Glu 
    1070                 1075                 1080             


Ala Asp  Ala Arg Leu Trp Leu  Gln Gln Leu Glu Glu  Lys Gly Arg 
    1085                 1090                 1095             


Tyr Ala  Lys Asp Val Ala 
    1100                 


<210>  103
<211>  3177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  103
atgccaagag tgcctgaagt cccaggtgtt ccattgttag gaaatctgtt acaattgaag       60

gagaaaaagc catacatgac ttttacgaga tgggcagcga catatggacc tatctatagt      120

atcaaaactg gggctacaag tatggttgtg gtatcatcta atgagatagc caaggaggca      180

ttggtgacca gattccaatc catatctaca aggaacttat ctaaagccct gaaagtactt      240

acagcagata agacaatggt cgcaatgtca gattatgatg attatcataa aacagttaag      300

agacacatac tgaccgccgt cttgggtcct aatgcacaga aaaagcatag aattcacaga      360

gatatcatga tggataacat atctactcaa cttcatgaat tcgtgaaaaa caacccagaa      420

caggaagagg tagaccttag aaaaatcttt caatctgagt tattcggctt agctatgaga      480

caagccttag gaaaggatgt tgaaagtttg tacgttgaag acctgaaaat cactatgaat      540

agagacgaaa tctttcaagt ccttgttgtt gatccaatga tgggagcaat cgatgttgat      600

tggagagact tctttccata cctaaagtgg gtcccaaaca aaaagttcga aaatactatt      660

caacaaatgt acatcagaag agaagctgtt atgaaatctt taatcaaaga gcacaaaaag      720

agaatagcgt caggcgaaaa gctaaatagt tatatcgatt accttttatc tgaagctcaa      780

actttaaccg atcagcaact attgatgtcc ttgtgggaac caatcattga atcttcagat      840

acaacaatgg tcacaacaga atgggcaatg tacgaattag ctaaaaaccc taaattgcaa      900

gataggttgt acagagacat taagtccgtc tgtggatctg aaaagataac cgaagagcat      960

ctatcacagc tgccttacat tacagctatt ttccacgaaa cactgagaag acactcacca     1020

gttcctatca ttcctctaag acatgtacat gaagataccg ttctaggcgg ctaccatgtt     1080

cctgctggca cagaacttgc cgttaacatc tacggttgca acatggacaa aaacgtttgg     1140

gaaaatccag aggaatggaa cccagaaaga ttcatgaaag agaatgagac aattgatttt     1200

caaaagacga tggccttcgg tggtggtaag agagtttgtg ctggttcctt gcaagccctt     1260

ttaactgcat ctattgggat tgggagaatg gttcaagagt tcgaatggaa actgaaggat     1320

atgactcaag aggaagtgaa cacgataggc ctaactacac aaatgttaag accattgaga     1380

gctattatca aacctaggat cccatcaaga ccaagtccta gtaccgaaca atctgcaaaa     1440

aaagttagaa aaaaagcaga aaatgcacac aatactccat tgctagttct ttatggttct     1500

aatatgggaa cagcggaagg aacggccagg gatctagctg acatagctat gtccaaggga     1560

tttgccccgc aagtagcaac cctggattcc catgcaggta acttgccaag agaaggtgct     1620

gttctaatag ttaccgctag ctacaatggg caccctccag ataatgcgaa gcagttcgtc     1680

gattggttag atcaagcatc agcagatgaa gttaagggtg ttagatactc tgtttttgga     1740

tgtggagata agaattgggc caccacatat cagaaggttc cggctttcat cgatgaaatg     1800

cttgctgcaa aaggggctga aaatatagca gatcgtggtg aggccgacgc aagcgacgat     1860

tttgagggta cctatgagga gtggagagag cacatgtggt ctgatgttgc cgcgtatttt     1920

aatctagaca tagaaaattc tgaagacaat aaaagtgcct tacttcttca attcgtcgat     1980

agtgctgcgg acatgccctt agcaaagatg catggagcct tttcaacgaa cgtagtagcc     2040

agtaaggaac ttcaacaacc aggtagtgcc agaagtacac gtcacttgga aattgaatta     2100

ccaaaagagg catcctacca agaaggtgac catcttggtg taatcccaag aaactacgaa     2160

ggtatagtca atagggtaac ggcaagattt gggctggatg caagccaaca gataagacta     2220

gaagcagaag aagaaaaatt ggcgcacctt ccactagcga agacagtatc cgttgaagaa     2280

ttattgcaat acgtggaatt gcaggatccc gtcactagaa cgcaattgag agctatggca     2340

gcaaagactg tttgtccacc tcacaaggtt gaacttgaag ctctacttga aaaacaagca     2400

tacaaagagc aagtgctagc aaagagacta accatgttag aattgctgga aaaatacccg     2460

gcatgcgaaa tggaattctc cgaatttatc gcgttgttgc caagtattcg tcccaggtat     2520

tactcaattt catcttcacc aagggttgac gagaaacagg catctattac cgtatctgtg     2580

gtctctggag aagcttggag tggttacgga gaatacaagg gtattgcttc caattatctt     2640

gcagaactgc aggaagggga tacaattacc tgctttattt ctactcctca atcagaattt     2700

actcttccga aggatccaga aactccgtta attatggtag gtccgggaac aggagtcgcc     2760

cctttcagag gctttgtgca agcaaggaag caactaaaag aacagggaca aagtctgggt     2820

gaggcacatc tatatttcgg ttgcagatct ccgcatgagg attacttata ccaagaagaa     2880

cttgaaaacg cccaatcaga aggtattatc accttgcata ctgcattcag tagaatgcca     2940

aaccagccga aaacttacgt acagcatgtt atggagcaag atggtaagaa gttaattgag     3000

cttttggata agggcgccca cttctacatt tgcggcgacg gatcccaaat ggcgcctgcc     3060

gttgaagcca ccttgatgaa atcatatgca gatgttcatc aagtttcaga agcggacgcc     3120

cgtctttggt tacaacaact agaggagaaa ggaaggtatg caaaagatgt ttggtaa        3177


<210>  104
<211>  1058
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  104

Met Pro Arg Val Pro Glu Val Pro Gly Val Pro Leu Leu Gly Asn Leu 
1               5                   10                  15      


Leu Gln Leu Lys Glu Lys Lys Pro Tyr Met Thr Phe Thr Arg Trp Ala 
            20                  25                  30          


Ala Thr Tyr Gly Pro Ile Tyr Ser Ile Lys Thr Gly Ala Thr Ser Met 
        35                  40                  45              


Val Val Val Ser Ser Asn Glu Ile Ala Lys Glu Ala Leu Val Thr Arg 
    50                  55                  60                  


Phe Gln Ser Ile Ser Thr Arg Asn Leu Ser Lys Ala Leu Lys Val Leu 
65                  70                  75                  80  


Thr Ala Asp Lys Thr Met Val Ala Met Ser Asp Tyr Asp Asp Tyr His 
                85                  90                  95      


Lys Thr Val Lys Arg His Ile Leu Thr Ala Val Leu Gly Pro Asn Ala 
            100                 105                 110         


Gln Lys Lys His Arg Ile His Arg Asp Ile Met Met Asp Asn Ile Ser 
        115                 120                 125             


Thr Gln Leu His Glu Phe Val Lys Asn Asn Pro Glu Gln Glu Glu Val 
    130                 135                 140                 


Asp Leu Arg Lys Ile Phe Gln Ser Glu Leu Phe Gly Leu Ala Met Arg 
145                 150                 155                 160 


Gln Ala Leu Gly Lys Asp Val Glu Ser Leu Tyr Val Glu Asp Leu Lys 
                165                 170                 175     


Ile Thr Met Asn Arg Asp Glu Ile Phe Gln Val Leu Val Val Asp Pro 
            180                 185                 190         


Met Met Gly Ala Ile Asp Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu 
        195                 200                 205             


Lys Trp Val Pro Asn Lys Lys Phe Glu Asn Thr Ile Gln Gln Met Tyr 
    210                 215                 220                 


Ile Arg Arg Glu Ala Val Met Lys Ser Leu Ile Lys Glu His Lys Lys 
225                 230                 235                 240 


Arg Ile Ala Ser Gly Glu Lys Leu Asn Ser Tyr Ile Asp Tyr Leu Leu 
                245                 250                 255     


Ser Glu Ala Gln Thr Leu Thr Asp Gln Gln Leu Leu Met Ser Leu Trp 
            260                 265                 270         


Glu Pro Ile Ile Glu Ser Ser Asp Thr Thr Met Val Thr Thr Glu Trp 
        275                 280                 285             


Ala Met Tyr Glu Leu Ala Lys Asn Pro Lys Leu Gln Asp Arg Leu Tyr 
    290                 295                 300                 


Arg Asp Ile Lys Ser Val Cys Gly Ser Glu Lys Ile Thr Glu Glu His 
305                 310                 315                 320 


Leu Ser Gln Leu Pro Tyr Ile Thr Ala Ile Phe His Glu Thr Leu Arg 
                325                 330                 335     


Arg His Ser Pro Val Pro Ile Ile Pro Leu Arg His Val His Glu Asp 
            340                 345                 350         


Thr Val Leu Gly Gly Tyr His Val Pro Ala Gly Thr Glu Leu Ala Val 
        355                 360                 365             


Asn Ile Tyr Gly Cys Asn Met Asp Lys Asn Val Trp Glu Asn Pro Glu 
    370                 375                 380                 


Glu Trp Asn Pro Glu Arg Phe Met Lys Glu Asn Glu Thr Ile Asp Phe 
385                 390                 395                 400 


Gln Lys Thr Met Ala Phe Gly Gly Gly Lys Arg Val Cys Ala Gly Ser 
                405                 410                 415     


Leu Gln Ala Leu Leu Thr Ala Ser Ile Gly Ile Gly Arg Met Val Gln 
            420                 425                 430         


Glu Phe Glu Trp Lys Leu Lys Asp Met Thr Gln Glu Glu Val Asn Thr 
        435                 440                 445             


Ile Gly Leu Thr Thr Gln Met Leu Arg Pro Leu Arg Ala Ile Ile Lys 
    450                 455                 460                 


Pro Arg Ile Pro Ser Arg Pro Ser Pro Ser Thr Glu Gln Ser Ala Lys 
465                 470                 475                 480 


Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr Pro Leu Leu Val 
                485                 490                 495     


Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr Ala Arg Asp Leu 
            500                 505                 510         


Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln Val Ala Thr Leu 
        515                 520                 525             


Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala Val Leu Ile Val 
    530                 535                 540                 


Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala Lys Gln Phe Val 
545                 550                 555                 560 


Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys Gly Val Arg Tyr 
                565                 570                 575     


Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr Thr Tyr Gln Lys 
            580                 585                 590         


Val Pro Ala Phe Ile Asp Glu Met Leu Ala Ala Lys Gly Ala Glu Asn 
        595                 600                 605             


Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp Phe Glu Gly Thr 
    610                 615                 620                 


Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val Ala Ala Tyr Phe 
625                 630                 635                 640 


Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser Ala Leu Leu Leu 
                645                 650                 655     


Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala Lys Met His Gly 
            660                 665                 670         


Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu Gln Gln Pro Gly 
        675                 680                 685             


Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu Pro Lys Glu Ala 
    690                 695                 700                 


Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro Arg Asn Tyr Glu 
705                 710                 715                 720 


Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly Leu Asp Ala Ser Gln 
                725                 730                 735     


Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala His Leu Pro Leu 
            740                 745                 750         


Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr Val Glu Leu Gln 
        755                 760                 765             


Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala Ala Lys Thr Val 
    770                 775                 780                 


Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu Glu Lys Gln Ala 
785                 790                 795                 800 


Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met Leu Glu Leu Leu 
                805                 810                 815     


Glu Lys Tyr Pro Ala Cys Glu Met Glu Phe Ser Glu Phe Ile Ala Leu 
            820                 825                 830         


Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg 
        835                 840                 845             


Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val Val Ser Gly Glu 
    850                 855                 860                 


Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala Ser Asn Tyr Leu 
865                 870                 875                 880 


Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe Ile Ser Thr Pro 
                885                 890                 895     


Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr Pro Leu Ile Met 
            900                 905                 910         


Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly Phe Val Gln Ala 
        915                 920                 925             


Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly Glu Ala His Leu 
    930                 935                 940                 


Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu Tyr Gln Glu Glu 
945                 950                 955                 960 


Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu His Thr Ala Phe 
                965                 970                 975     


Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln His Val Met Glu 
            980                 985                 990         


Gln Asp Gly Lys Lys Leu Ile Glu  Leu Leu Asp Lys Gly  Ala His Phe 
        995                 1000                 1005             


Tyr Ile  Cys Gly Asp Gly Ser  Gln Met Ala Pro Ala  Val Glu Ala 
    1010                 1015                 1020             


Thr Leu  Met Lys Ser Tyr Ala  Asp Val His Gln Val  Ser Glu Ala 
    1025                 1030                 1035             


Asp Ala  Arg Leu Trp Leu Gln  Gln Leu Glu Glu Lys  Gly Arg Tyr 
    1040                 1045                 1050             


Ala Lys  Asp Val Trp 
    1055             


<210>  105
<211>  3177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  105
atgccaagag tgcctgaagt cccaggtgtt ccattgttag gaaatctgtt acaattgaag       60

gagaaaaagc catacatgac ttttacgaga tgggcagcga catatggacc tatctatagt      120

atcaaaactg gggctacaag tatggttgtg gtatcatcta atgagatagc caaggaggca      180

ttggtgacca gattccaatc catatctaca aggaacttat ctaaagccct gaaagtactt      240

acagcagata agacaatggt cgcaatgtca gattatgatg attatcataa aacagttaag      300

agacacatac tgaccgccgt cttgggtcct aatgcacaga aaaagcatag aattcacaga      360

gatatcatga tggataacat atctactcaa cttcatgaat tcgtgaaaaa caacccagaa      420

caggaagagg tagaccttag aaaaatcttt caatctgagt tattcggctt agctatgaga      480

caagccttag gaaaggatgt tgaaagtttg tacgttgaag acctgaaaat cactatgaat      540

agagacgaaa tctttcaagt ccttgttgtt gatccaatga tgggagcaat cgatgttgat      600

tggagagact tctttccata cctaaagtgg gtcccaaaca aaaagttcga aaatactatt      660

caacaaatgt acatcagaag agaagctgtt atgaaatctt taatcaaaga gcacaaaaag      720

agaatagcgt caggcgaaaa gctaaatagt tatatcgatt accttttatc tgaagctcaa      780

actttaaccg atcagcaact attgatgtcc ttgtgggaac caatcattga atcttcagat      840

acaacaatgg tcacaacaga atgggcaatg tacgaattag ctaaaaaccc taaattgcaa      900

gataggttgt acagagacat taagtccgtc tgtggatctg aaaagataac cgaagagcat      960

ctatcacagc tgccttacat tacagctatt ttccacgaaa cactgagaag acactcacca     1020

gttcctatca ttcctctaag acatgtacat gaagataccg ttctaggcgg ctaccatgtt     1080

cctgctggca cagaacttgc cgttaacatc tacggttgca acatggacaa aaacgtttgg     1140

gaaaatccag aggaatggaa cccagaaaga ttcatgaaag agaatgagac aattgatttt     1200

caaaagacga tggccttcgg tggtggtaag agagtttgtg ctggttcctt gcaagccctt     1260

ttaactgcat ctattgggat tgggagaatg gttcaagagt tcgaatggaa actgaaggat     1320

atgactcaag aggaagtgaa cacgataggc ctaactacac aaatgttaag accattgaga     1380

gctattatca aacctaggat cccatcaaga ccaagtccta gtaccgaaca atctgcaaaa     1440

aaagttagaa aaaaagcaga aaatgcacac aatactccat tgctagttct ttatggttct     1500

aatatgggaa cagcggaagg aacggccagg gatctagctg acatagctat gtccaaggga     1560

tttgccccgc aagtagcaac cctggattcc catgcaggta acttgccaag agaaggtgct     1620

gttctaatag ttaccgctag ctacaatggg caccctccag ataatgcgaa gcagttcgtc     1680

gattggttag atcaagcatc agcagatgaa gttaagggtg ttagatactc tgtttttgga     1740

tgtggagata agaattgggc caccacatat cagaaggttc cggctttcat cgatgaaatg     1800

cttgctgcaa aaggggctga aaatatagca gatcgtggtg aggccgacgc aagcgacgat     1860

tttgagggta cctatgagga gtggagagag cacatgtggt ctgatgttgc cgcgtatttt     1920

aatctagaca tagaaaattc tgaagacaat aaaagtgcct tacttcttca attcgtcgat     1980

agtgctgcgg acatgccctt agcaaagatg catggagcct tttcaacgaa cgtagtagcc     2040

agtaaggaac ttcaacaacc aggtagtgcc agaagtacac gtcacttgga aattgaatta     2100

ccaaaagagg catcctacca agaaggtgac catcttggtg taatcccaag aaactacgaa     2160

ggtatagtca atagggtaac ggcaagattt gggctggatg caagccaaca gataagacta     2220

gaagcagaag aagaaaaatt ggcgcacctt ccactagcga agacagtatc cgttgaagaa     2280

ttattgcaat acgtggaatt gcaggatccc gtcactagaa cgcaattgag agctatggca     2340

gcaaagactg tttgtccacc tcacaaggtt gaacttgaag ctctacttga aaaacaagca     2400

tacaaagagc aagtgctagc aaagagacta accatgttag aattgctgga aaaatacccg     2460

gcatgcgaaa tggaattctc cgaatttatc gcgttgttgc caagtattcg tcccaggtat     2520

tactcaattt catcttcacc aagggttgac gagaaacagg catctattac cgtatctgtg     2580

gtctctggag aagcttggag tggttacgga gaatacaagg gtattgcttc caattatctt     2640

gcagaactgc aggaagggga tacaattacc tgctttattt ctactcctca atcagaattt     2700

actcttccga aggatccaga aactccgtta attatggtag gtccgggaac aggagtcgcc     2760

cctttcagag gctttgtgca agcaaggaag caactaaaag aacagggaca aagtctgggt     2820

gaggcacatc tatatttcgg ttgcagatct ccgcatgagg attacttata ccaagaagaa     2880

cttgaaaacg cccaatcaga aggtattatc accttgcata ctgcattcag tagaatgcca     2940

aaccagccga aaacttacgt acagcatgtt atggagcaag atggtaagaa gttaattgag     3000

cttttggata agggcgccca cttctacatt tgcggcgacg gatcccaaat ggcgcctgcc     3060

gttgaagcca ccttgatgaa atcatatgca gatgttcatc aagtttcaga agcggacgcc     3120

cgtctttggt tacaacaact agaggagaaa ggaaggtatg caaaagatgt tgcttaa        3177


<210>  106
<211>  1058
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  106

Met Pro Arg Val Pro Glu Val Pro Gly Val Pro Leu Leu Gly Asn Leu 
1               5                   10                  15      


Leu Gln Leu Lys Glu Lys Lys Pro Tyr Met Thr Phe Thr Arg Trp Ala 
            20                  25                  30          


Ala Thr Tyr Gly Pro Ile Tyr Ser Ile Lys Thr Gly Ala Thr Ser Met 
        35                  40                  45              


Val Val Val Ser Ser Asn Glu Ile Ala Lys Glu Ala Leu Val Thr Arg 
    50                  55                  60                  


Phe Gln Ser Ile Ser Thr Arg Asn Leu Ser Lys Ala Leu Lys Val Leu 
65                  70                  75                  80  


Thr Ala Asp Lys Thr Met Val Ala Met Ser Asp Tyr Asp Asp Tyr His 
                85                  90                  95      


Lys Thr Val Lys Arg His Ile Leu Thr Ala Val Leu Gly Pro Asn Ala 
            100                 105                 110         


Gln Lys Lys His Arg Ile His Arg Asp Ile Met Met Asp Asn Ile Ser 
        115                 120                 125             


Thr Gln Leu His Glu Phe Val Lys Asn Asn Pro Glu Gln Glu Glu Val 
    130                 135                 140                 


Asp Leu Arg Lys Ile Phe Gln Ser Glu Leu Phe Gly Leu Ala Met Arg 
145                 150                 155                 160 


Gln Ala Leu Gly Lys Asp Val Glu Ser Leu Tyr Val Glu Asp Leu Lys 
                165                 170                 175     


Ile Thr Met Asn Arg Asp Glu Ile Phe Gln Val Leu Val Val Asp Pro 
            180                 185                 190         


Met Met Gly Ala Ile Asp Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu 
        195                 200                 205             


Lys Trp Val Pro Asn Lys Lys Phe Glu Asn Thr Ile Gln Gln Met Tyr 
    210                 215                 220                 


Ile Arg Arg Glu Ala Val Met Lys Ser Leu Ile Lys Glu His Lys Lys 
225                 230                 235                 240 


Arg Ile Ala Ser Gly Glu Lys Leu Asn Ser Tyr Ile Asp Tyr Leu Leu 
                245                 250                 255     


Ser Glu Ala Gln Thr Leu Thr Asp Gln Gln Leu Leu Met Ser Leu Trp 
            260                 265                 270         


Glu Pro Ile Ile Glu Ser Ser Asp Thr Thr Met Val Thr Thr Glu Trp 
        275                 280                 285             


Ala Met Tyr Glu Leu Ala Lys Asn Pro Lys Leu Gln Asp Arg Leu Tyr 
    290                 295                 300                 


Arg Asp Ile Lys Ser Val Cys Gly Ser Glu Lys Ile Thr Glu Glu His 
305                 310                 315                 320 


Leu Ser Gln Leu Pro Tyr Ile Thr Ala Ile Phe His Glu Thr Leu Arg 
                325                 330                 335     


Arg His Ser Pro Val Pro Ile Ile Pro Leu Arg His Val His Glu Asp 
            340                 345                 350         


Thr Val Leu Gly Gly Tyr His Val Pro Ala Gly Thr Glu Leu Ala Val 
        355                 360                 365             


Asn Ile Tyr Gly Cys Asn Met Asp Lys Asn Val Trp Glu Asn Pro Glu 
    370                 375                 380                 


Glu Trp Asn Pro Glu Arg Phe Met Lys Glu Asn Glu Thr Ile Asp Phe 
385                 390                 395                 400 


Gln Lys Thr Met Ala Phe Gly Gly Gly Lys Arg Val Cys Ala Gly Ser 
                405                 410                 415     


Leu Gln Ala Leu Leu Thr Ala Ser Ile Gly Ile Gly Arg Met Val Gln 
            420                 425                 430         


Glu Phe Glu Trp Lys Leu Lys Asp Met Thr Gln Glu Glu Val Asn Thr 
        435                 440                 445             


Ile Gly Leu Thr Thr Gln Met Leu Arg Pro Leu Arg Ala Ile Ile Lys 
    450                 455                 460                 


Pro Arg Ile Pro Ser Arg Pro Ser Pro Ser Thr Glu Gln Ser Ala Lys 
465                 470                 475                 480 


Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr Pro Leu Leu Val 
                485                 490                 495     


Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr Ala Arg Asp Leu 
            500                 505                 510         


Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln Val Ala Thr Leu 
        515                 520                 525             


Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala Val Leu Ile Val 
    530                 535                 540                 


Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala Lys Gln Phe Val 
545                 550                 555                 560 


Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys Gly Val Arg Tyr 
                565                 570                 575     


Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr Thr Tyr Gln Lys 
            580                 585                 590         


Val Pro Ala Phe Ile Asp Glu Met Leu Ala Ala Lys Gly Ala Glu Asn 
        595                 600                 605             


Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp Phe Glu Gly Thr 
    610                 615                 620                 


Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val Ala Ala Tyr Phe 
625                 630                 635                 640 


Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser Ala Leu Leu Leu 
                645                 650                 655     


Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala Lys Met His Gly 
            660                 665                 670         


Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu Gln Gln Pro Gly 
        675                 680                 685             


Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu Pro Lys Glu Ala 
    690                 695                 700                 


Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro Arg Asn Tyr Glu 
705                 710                 715                 720 


Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly Leu Asp Ala Ser Gln 
                725                 730                 735     


Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala His Leu Pro Leu 
            740                 745                 750         


Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr Val Glu Leu Gln 
        755                 760                 765             


Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala Ala Lys Thr Val 
    770                 775                 780                 


Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu Glu Lys Gln Ala 
785                 790                 795                 800 


Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met Leu Glu Leu Leu 
                805                 810                 815     


Glu Lys Tyr Pro Ala Cys Glu Met Glu Phe Ser Glu Phe Ile Ala Leu 
            820                 825                 830         


Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg 
        835                 840                 845             


Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val Val Ser Gly Glu 
    850                 855                 860                 


Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala Ser Asn Tyr Leu 
865                 870                 875                 880 


Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe Ile Ser Thr Pro 
                885                 890                 895     


Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr Pro Leu Ile Met 
            900                 905                 910         


Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly Phe Val Gln Ala 
        915                 920                 925             


Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly Glu Ala His Leu 
    930                 935                 940                 


Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu Tyr Gln Glu Glu 
945                 950                 955                 960 


Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu His Thr Ala Phe 
                965                 970                 975     


Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln His Val Met Glu 
            980                 985                 990         


Gln Asp Gly Lys Lys Leu Ile Glu  Leu Leu Asp Lys Gly  Ala His Phe 
        995                 1000                 1005             


Tyr Ile  Cys Gly Asp Gly Ser  Gln Met Ala Pro Ala  Val Glu Ala 
    1010                 1015                 1020             


Thr Leu  Met Lys Ser Tyr Ala  Asp Val His Gln Val  Ser Glu Ala 
    1025                 1030                 1035             


Asp Ala  Arg Leu Trp Leu Gln  Gln Leu Glu Glu Lys  Gly Arg Tyr 
    1040                 1045                 1050             


Ala Lys  Asp Val Ala 
    1055             


<210>  107
<211>  3309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  107
atggctacct tgttggaaca ttttcaagct atgccattcg ctattccaat tgctttggct       60

gctttgtctt ggttgttttt gttctacatc aaggtttctt tcttctccaa caaatccgct      120

caagctaaat tgccaccagt tccagttgtt ccaggtttgc cagttattgg taatttgttg      180

caattgaaag aaaagaagcc ataccaaacc ttcactagat gggctgaaga atatggtcca      240

atctactcta ttagaactgg tgcttctact atggttgtct tgaacactac tcaagttgcc      300

aaagaagcta tggttaccag atacttgtct atctctacca gaaagttgtc caacgccttg      360

aaaattttga ccgctgataa gtgcatggtt gccatttctg attacaacga tttccacaag      420

atgatcaaga gatatatctt gtctaacgtt ttgggtccat ctgcccaaaa aagacataga      480

tctaacagag ataccttgag agccaacgtt tgttctagat tgcattccca agttaagaac      540

tctccaagag aagctgtcaa ctttagaaga gttttcgaat gggaattatt cggtatcgct      600

ttgaaacaag ccttcggtaa ggatattgaa aagccaatct acgtcgaaga attgggtact      660

actttgtcca gagatgaaat cttcaaggtt ttggtcttgg acattatgga aggtgccatt      720

gaagttgatt ggagagattt tttcccatac ttgcgttgga ttccaaacac cagaatggaa      780

actaagatcc aaagattata ctttagaaga aaggccgtta tgaccgcctt gattaacgaa      840

caaaagaaaa gaattgcctc cggtgaagaa atcaactgct acatcgattt cttgttgaaa      900

gaaggtaaga ccttgaccat ggaccaaatc tctatgttgt tgtgggaaac cgttattgaa      960

actgctgata ccacaatggt tactactgaa tgggctatgt acgaagttgc taaggattct     1020

aaaagacaag acagattata ccaagaaatc caaaaggtct gcggttctga aatggttaca     1080

gaagaatact tgtcccaatt gccatacttg aatgctgttt tccacgaaac tttgagaaaa     1140

cattctccag ctgctttggt tccattgaga tatgctcatg aagatactca attgggtggt     1200

tattacattc cagccggtac tgaaattgcc attaacatct acggttgcaa catggacaaa     1260

caccaatggg aatctccaga agaatggaag ccagaaagat ttttggatcc taagtttgac     1320

ccaatggact tgtacaaaac tatggctttt ggtgctggta aaagagtttg cgctggttct     1380

ttacaagcta tgttgattgc ttgtccaacc atcggtagat tggttcaaga atttgaatgg     1440

aagttgagag atggtgaaga agaaaacgtt gatactgttg gtttgaccac ccataagaga     1500

tatccaatgc atgctatttt gaagccaaga tctccatcaa gaccaagtcc tagtaccgaa     1560

caatctgcaa aaaaagttag aaaaaaagca gaaaatgcac acaatactcc attgctagtt     1620

ctttatggtt ctaatatggg aacagcggaa ggaacggcca gggatctagc tgacatagct     1680

atgtccaagg gatttgcccc gcaagtagca accctggatt cccatgcagg taacttgcca     1740

agagaaggtg ctgttctaat agttaccgct agctacaatg ggcaccctcc agataatgcg     1800

aagcagttcg tcgattggtt agatcaagca tcagcagatg aagttaaggg tgttagatac     1860

tctgtttttg gatgtggaga taagaattgg gccaccacat atcagaaggt tccggctttc     1920

atcgatgaaa tgcttgctgc aaaaggggct gaaaatatag cagatcgtgg tgaggccgac     1980

gcaagcgacg attttgaggg tacctatgag gagtggagag agcacatgtg gtctgatgtt     2040

gccgcgtatt ttaatctaga catagaaaat tctgaagaca ataaaagtgc cttacttctt     2100

caattcgtcg atagtgctgc ggacatgccc ttagcaaaga tgcatggagc cttttcaacg     2160

aacgtagtag ccagtaagga acttcaacaa ccaggtagtg ccagaagtac acgtcacttg     2220

gaaattgaat taccaaaaga ggcatcctac caagaaggtg accatcttgg tgtaatccca     2280

agaaactacg aaggtatagt caatagggta acggcaagat ttgggctgga tgcaagccaa     2340

cagataagac tagaagcaga agaagaaaaa ttggcgcacc ttccactagc gaagacagta     2400

tccgttgaag aattattgca atacgtggaa ttgcaggatc ccgtcactag aacgcaattg     2460

agagctatgg cagcaaagac tgtttgtcca cctcacaagg ttgaacttga agctctactt     2520

gaaaaacaag catacaaaga gcaagtgcta gcaaagagac taaccatgtt agaattgctg     2580

gaaaaatacc cggcatgcga aatggaattc tccgaattta tcgcgttgtt gccaagtatt     2640

cgtcccaggt attactcaat ttcatcttca ccaagggttg acgagaaaca ggcatctatt     2700

accgtatctg tggtctctgg agaagcttgg agtggttacg gagaatacaa gggtattgct     2760

tccaattatc ttgcagaact gcaggaaggg gatacaatta cctgctttat ttctactcct     2820

caatcagaat ttactcttcc gaaggatcca gaaactccgt taattatggt aggtccggga     2880

acaggagtcg cccctttcag aggctttgtg caagcaagga agcaactaaa agaacaggga     2940

caaagtctgg gtgaggcaca tctatatttc ggttgcagat ctccgcatga ggattactta     3000

taccaagaag aacttgaaaa cgcccaatca gaaggtatta tcaccttgca tactgcattc     3060

agtagaatgc caaaccagcc gaaaacttac gtacagcatg ttatggagca agatggtaag     3120

aagttaattg agcttttgga taagggcgcc cacttctaca tttgcggcga cggatcccaa     3180

atggcgcctg ccgttgaagc caccttgatg aaatcatatg cagatgttca tcaagtttca     3240

gaagcggacg cccgtctttg gttacaacaa ctagaggaga aaggaaggta tgcaaaagat     3300

gtttggtaa                                                             3309


<210>  108
<211>  1102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  108

Met Ala Thr Leu Leu Glu His Phe Gln Ala Met Pro Phe Ala Ile Pro 
1               5                   10                  15      


Ile Ala Leu Ala Ala Leu Ser Trp Leu Phe Leu Phe Tyr Ile Lys Val 
            20                  25                  30          


Ser Phe Phe Ser Asn Lys Ser Ala Gln Ala Lys Leu Pro Pro Val Pro 
        35                  40                  45              


Val Val Pro Gly Leu Pro Val Ile Gly Asn Leu Leu Gln Leu Lys Glu 
    50                  55                  60                  


Lys Lys Pro Tyr Gln Thr Phe Thr Arg Trp Ala Glu Glu Tyr Gly Pro 
65                  70                  75                  80  


Ile Tyr Ser Ile Arg Thr Gly Ala Ser Thr Met Val Val Leu Asn Thr 
                85                  90                  95      


Thr Gln Val Ala Lys Glu Ala Met Val Thr Arg Tyr Leu Ser Ile Ser 
            100                 105                 110         


Thr Arg Lys Leu Ser Asn Ala Leu Lys Ile Leu Thr Ala Asp Lys Cys 
        115                 120                 125             


Met Val Ala Ile Ser Asp Tyr Asn Asp Phe His Lys Met Ile Lys Arg 
    130                 135                 140                 


Tyr Ile Leu Ser Asn Val Leu Gly Pro Ser Ala Gln Lys Arg His Arg 
145                 150                 155                 160 


Ser Asn Arg Asp Thr Leu Arg Ala Asn Val Cys Ser Arg Leu His Ser 
                165                 170                 175     


Gln Val Lys Asn Ser Pro Arg Glu Ala Val Asn Phe Arg Arg Val Phe 
            180                 185                 190         


Glu Trp Glu Leu Phe Gly Ile Ala Leu Lys Gln Ala Phe Gly Lys Asp 
        195                 200                 205             


Ile Glu Lys Pro Ile Tyr Val Glu Glu Leu Gly Thr Thr Leu Ser Arg 
    210                 215                 220                 


Asp Glu Ile Phe Lys Val Leu Val Leu Asp Ile Met Glu Gly Ala Ile 
225                 230                 235                 240 


Glu Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Arg Trp Ile Pro Asn 
                245                 250                 255     


Thr Arg Met Glu Thr Lys Ile Gln Arg Leu Tyr Phe Arg Arg Lys Ala 
            260                 265                 270         


Val Met Thr Ala Leu Ile Asn Glu Gln Lys Lys Arg Ile Ala Ser Gly 
        275                 280                 285             


Glu Glu Ile Asn Cys Tyr Ile Asp Phe Leu Leu Lys Glu Gly Lys Thr 
    290                 295                 300                 


Leu Thr Met Asp Gln Ile Ser Met Leu Leu Trp Glu Thr Val Ile Glu 
305                 310                 315                 320 


Thr Ala Asp Thr Thr Met Val Thr Thr Glu Trp Ala Met Tyr Glu Val 
                325                 330                 335     


Ala Lys Asp Ser Lys Arg Gln Asp Arg Leu Tyr Gln Glu Ile Gln Lys 
            340                 345                 350         


Val Cys Gly Ser Glu Met Val Thr Glu Glu Tyr Leu Ser Gln Leu Pro 
        355                 360                 365             


Tyr Leu Asn Ala Val Phe His Glu Thr Leu Arg Lys His Ser Pro Ala 
    370                 375                 380                 


Ala Leu Val Pro Leu Arg Tyr Ala His Glu Asp Thr Gln Leu Gly Gly 
385                 390                 395                 400 


Tyr Tyr Ile Pro Ala Gly Thr Glu Ile Ala Ile Asn Ile Tyr Gly Cys 
                405                 410                 415     


Asn Met Asp Lys His Gln Trp Glu Ser Pro Glu Glu Trp Lys Pro Glu 
            420                 425                 430         


Arg Phe Leu Asp Pro Lys Phe Asp Pro Met Asp Leu Tyr Lys Thr Met 
        435                 440                 445             


Ala Phe Gly Ala Gly Lys Arg Val Cys Ala Gly Ser Leu Gln Ala Met 
    450                 455                 460                 


Leu Ile Ala Cys Pro Thr Ile Gly Arg Leu Val Gln Glu Phe Glu Trp 
465                 470                 475                 480 


Lys Leu Arg Asp Gly Glu Glu Glu Asn Val Asp Thr Val Gly Leu Thr 
                485                 490                 495     


Thr His Lys Arg Tyr Pro Met His Ala Ile Leu Lys Pro Arg Ser Pro 
            500                 505                 510         


Ser Arg Pro Ser Pro Ser Thr Glu Gln Ser Ala Lys Lys Val Arg Lys 
        515                 520                 525             


Lys Ala Glu Asn Ala His Asn Thr Pro Leu Leu Val Leu Tyr Gly Ser 
    530                 535                 540                 


Asn Met Gly Thr Ala Glu Gly Thr Ala Arg Asp Leu Ala Asp Ile Ala 
545                 550                 555                 560 


Met Ser Lys Gly Phe Ala Pro Gln Val Ala Thr Leu Asp Ser His Ala 
                565                 570                 575     


Gly Asn Leu Pro Arg Glu Gly Ala Val Leu Ile Val Thr Ala Ser Tyr 
            580                 585                 590         


Asn Gly His Pro Pro Asp Asn Ala Lys Gln Phe Val Asp Trp Leu Asp 
        595                 600                 605             


Gln Ala Ser Ala Asp Glu Val Lys Gly Val Arg Tyr Ser Val Phe Gly 
    610                 615                 620                 


Cys Gly Asp Lys Asn Trp Ala Thr Thr Tyr Gln Lys Val Pro Ala Phe 
625                 630                 635                 640 


Ile Asp Glu Met Leu Ala Ala Lys Gly Ala Glu Asn Ile Ala Asp Arg 
                645                 650                 655     


Gly Glu Ala Asp Ala Ser Asp Asp Phe Glu Gly Thr Tyr Glu Glu Trp 
            660                 665                 670         


Arg Glu His Met Trp Ser Asp Val Ala Ala Tyr Phe Asn Leu Asp Ile 
        675                 680                 685             


Glu Asn Ser Glu Asp Asn Lys Ser Ala Leu Leu Leu Gln Phe Val Asp 
    690                 695                 700                 


Ser Ala Ala Asp Met Pro Leu Ala Lys Met His Gly Ala Phe Ser Thr 
705                 710                 715                 720 


Asn Val Val Ala Ser Lys Glu Leu Gln Gln Pro Gly Ser Ala Arg Ser 
                725                 730                 735     


Thr Arg His Leu Glu Ile Glu Leu Pro Lys Glu Ala Ser Tyr Gln Glu 
            740                 745                 750         


Gly Asp His Leu Gly Val Ile Pro Arg Asn Tyr Glu Gly Ile Val Asn 
        755                 760                 765             


Arg Val Thr Ala Arg Phe Gly Leu Asp Ala Ser Gln Gln Ile Arg Leu 
    770                 775                 780                 


Glu Ala Glu Glu Glu Lys Leu Ala His Leu Pro Leu Ala Lys Thr Val 
785                 790                 795                 800 


Ser Val Glu Glu Leu Leu Gln Tyr Val Glu Leu Gln Asp Pro Val Thr 
                805                 810                 815     


Arg Thr Gln Leu Arg Ala Met Ala Ala Lys Thr Val Cys Pro Pro His 
            820                 825                 830         


Lys Val Glu Leu Glu Ala Leu Leu Glu Lys Gln Ala Tyr Lys Glu Gln 
        835                 840                 845             


Val Leu Ala Lys Arg Leu Thr Met Leu Glu Leu Leu Glu Lys Tyr Pro 
    850                 855                 860                 


Ala Cys Glu Met Glu Phe Ser Glu Phe Ile Ala Leu Leu Pro Ser Ile 
865                 870                 875                 880 


Arg Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Val Asp Glu Lys 
                885                 890                 895     


Gln Ala Ser Ile Thr Val Ser Val Val Ser Gly Glu Ala Trp Ser Gly 
            900                 905                 910         


Tyr Gly Glu Tyr Lys Gly Ile Ala Ser Asn Tyr Leu Ala Glu Leu Gln 
        915                 920                 925             


Glu Gly Asp Thr Ile Thr Cys Phe Ile Ser Thr Pro Gln Ser Glu Phe 
    930                 935                 940                 


Thr Leu Pro Lys Asp Pro Glu Thr Pro Leu Ile Met Val Gly Pro Gly 
945                 950                 955                 960 


Thr Gly Val Ala Pro Phe Arg Gly Phe Val Gln Ala Arg Lys Gln Leu 
                965                 970                 975     


Lys Glu Gln Gly Gln Ser Leu Gly Glu Ala His Leu Tyr Phe Gly Cys 
            980                 985                 990         


Arg Ser Pro His Glu Asp Tyr Leu  Tyr Gln Glu Glu Leu  Glu Asn Ala 
        995                 1000                 1005             


Gln Ser  Glu Gly Ile Ile Thr  Leu His Thr Ala Phe  Ser Arg Met 
    1010                 1015                 1020             


Pro Asn  Gln Pro Lys Thr Tyr  Val Gln His Val Met  Glu Gln Asp 
    1025                 1030                 1035             


Gly Lys  Lys Leu Ile Glu Leu  Leu Asp Lys Gly Ala  His Phe Tyr 
    1040                 1045                 1050             


Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro Ala Val  Glu Ala Thr 
    1055                 1060                 1065             


Leu Met  Lys Ser Tyr Ala Asp  Val His Gln Val Ser  Glu Ala Asp 
    1070                 1075                 1080             


Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu Lys Gly  Arg Tyr Ala 
    1085                 1090                 1095             


Lys Asp  Val Trp 
    1100         


<210>  109
<211>  3309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  109
atggctacct tgttggaaca ttttcaagct atgccattcg ctattccaat tgctttggct       60

gctttgtctt ggttgttttt gttctacatc aaggtttctt tcttctccaa caaatccgct      120

caagctaaat tgccaccagt tccagttgtt ccaggtttgc cagttattgg taatttgttg      180

caattgaaag aaaagaagcc ataccaaacc ttcactagat gggctgaaga atatggtcca      240

atctactcta ttagaactgg tgcttctact atggttgtct tgaacactac tcaagttgcc      300

aaagaagcta tggttaccag atacttgtct atctctacca gaaagttgtc caacgccttg      360

aaaattttga ccgctgataa gtgcatggtt gccatttctg attacaacga tttccacaag      420

atgatcaaga gatatatctt gtctaacgtt ttgggtccat ctgcccaaaa aagacataga      480

tctaacagag ataccttgag agccaacgtt tgttctagat tgcattccca agttaagaac      540

tctccaagag aagctgtcaa ctttagaaga gttttcgaat gggaattatt cggtatcgct      600

ttgaaacaag ccttcggtaa ggatattgaa aagccaatct acgtcgaaga attgggtact      660

actttgtcca gagatgaaat cttcaaggtt ttggtcttgg acattatgga aggtgccatt      720

gaagttgatt ggagagattt tttcccatac ttgcgttgga ttccaaacac cagaatggaa      780

actaagatcc aaagattata ctttagaaga aaggccgtta tgaccgcctt gattaacgaa      840

caaaagaaaa gaattgcctc cggtgaagaa atcaactgct acatcgattt cttgttgaaa      900

gaaggtaaga ccttgaccat ggaccaaatc tctatgttgt tgtgggaaac cgttattgaa      960

actgctgata ccacaatggt tactactgaa tgggctatgt acgaagttgc taaggattct     1020

aaaagacaag acagattata ccaagaaatc caaaaggtct gcggttctga aatggttaca     1080

gaagaatact tgtcccaatt gccatacttg aatgctgttt tccacgaaac tttgagaaaa     1140

cattctccag ctgctttggt tccattgaga tatgctcatg aagatactca attgggtggt     1200

tattacattc cagccggtac tgaaattgcc attaacatct acggttgcaa catggacaaa     1260

caccaatggg aatctccaga agaatggaag ccagaaagat ttttggatcc taagtttgac     1320

ccaatggact tgtacaaaac tatggctttt ggtgctggta aaagagtttg cgctggttct     1380

ttacaagcta tgttgattgc ttgtccaacc atcggtagat tggttcaaga atttgaatgg     1440

aagttgagag atggtgaaga agaaaacgtt gatactgttg gtttgaccac ccataagaga     1500

tatccaatgc atgctatttt gaagccaaga tctccatcaa gaccaagtcc tagtaccgaa     1560

caatctgcaa aaaaagttag aaaaaaagca gaaaatgcac acaatactcc attgctagtt     1620

ctttatggtt ctaatatggg aacagcggaa ggaacggcca gggatctagc tgacatagct     1680

atgtccaagg gatttgcccc gcaagtagca accctggatt cccatgcagg taacttgcca     1740

agagaaggtg ctgttctaat agttaccgct agctacaatg ggcaccctcc agataatgcg     1800

aagcagttcg tcgattggtt agatcaagca tcagcagatg aagttaaggg tgttagatac     1860

tctgtttttg gatgtggaga taagaattgg gccaccacat atcagaaggt tccggctttc     1920

atcgatgaaa tgcttgctgc aaaaggggct gaaaatatag cagatcgtgg tgaggccgac     1980

gcaagcgacg attttgaggg tacctatgag gagtggagag agcacatgtg gtctgatgtt     2040

gccgcgtatt ttaatctaga catagaaaat tctgaagaca ataaaagtgc cttacttctt     2100

caattcgtcg atagtgctgc ggacatgccc ttagcaaaga tgcatggagc cttttcaacg     2160

aacgtagtag ccagtaagga acttcaacaa ccaggtagtg ccagaagtac acgtcacttg     2220

gaaattgaat taccaaaaga ggcatcctac caagaaggtg accatcttgg tgtaatccca     2280

agaaactacg aaggtatagt caatagggta acggcaagat ttgggctgga tgcaagccaa     2340

cagataagac tagaagcaga agaagaaaaa ttggcgcacc ttccactagc gaagacagta     2400

tccgttgaag aattattgca atacgtggaa ttgcaggatc ccgtcactag aacgcaattg     2460

agagctatgg cagcaaagac tgtttgtcca cctcacaagg ttgaacttga agctctactt     2520

gaaaaacaag catacaaaga gcaagtgcta gcaaagagac taaccatgtt agaattgctg     2580

gaaaaatacc cggcatgcga aatggaattc tccgaattta tcgcgttgtt gccaagtatt     2640

cgtcccaggt attactcaat ttcatcttca ccaagggttg acgagaaaca ggcatctatt     2700

accgtatctg tggtctctgg agaagcttgg agtggttacg gagaatacaa gggtattgct     2760

tccaattatc ttgcagaact gcaggaaggg gatacaatta cctgctttat ttctactcct     2820

caatcagaat ttactcttcc gaaggatcca gaaactccgt taattatggt aggtccggga     2880

acaggagtcg cccctttcag aggctttgtg caagcaagga agcaactaaa agaacaggga     2940

caaagtctgg gtgaggcaca tctatatttc ggttgcagat ctccgcatga ggattactta     3000

taccaagaag aacttgaaaa cgcccaatca gaaggtatta tcaccttgca tactgcattc     3060

agtagaatgc caaaccagcc gaaaacttac gtacagcatg ttatggagca agatggtaag     3120

aagttaattg agcttttgga taagggcgcc cacttctaca tttgcggcga cggatcccaa     3180

atggcgcctg ccgttgaagc caccttgatg aaatcatatg cagatgttca tcaagtttca     3240

gaagcggacg cccgtctttg gttacaacaa ctagaggaga aaggaaggta tgcaaaagat     3300

gttgcttaa                                                             3309


<210>  110
<211>  1102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  110

Met Ala Thr Leu Leu Glu His Phe Gln Ala Met Pro Phe Ala Ile Pro 
1               5                   10                  15      


Ile Ala Leu Ala Ala Leu Ser Trp Leu Phe Leu Phe Tyr Ile Lys Val 
            20                  25                  30          


Ser Phe Phe Ser Asn Lys Ser Ala Gln Ala Lys Leu Pro Pro Val Pro 
        35                  40                  45              


Val Val Pro Gly Leu Pro Val Ile Gly Asn Leu Leu Gln Leu Lys Glu 
    50                  55                  60                  


Lys Lys Pro Tyr Gln Thr Phe Thr Arg Trp Ala Glu Glu Tyr Gly Pro 
65                  70                  75                  80  


Ile Tyr Ser Ile Arg Thr Gly Ala Ser Thr Met Val Val Leu Asn Thr 
                85                  90                  95      


Thr Gln Val Ala Lys Glu Ala Met Val Thr Arg Tyr Leu Ser Ile Ser 
            100                 105                 110         


Thr Arg Lys Leu Ser Asn Ala Leu Lys Ile Leu Thr Ala Asp Lys Cys 
        115                 120                 125             


Met Val Ala Ile Ser Asp Tyr Asn Asp Phe His Lys Met Ile Lys Arg 
    130                 135                 140                 


Tyr Ile Leu Ser Asn Val Leu Gly Pro Ser Ala Gln Lys Arg His Arg 
145                 150                 155                 160 


Ser Asn Arg Asp Thr Leu Arg Ala Asn Val Cys Ser Arg Leu His Ser 
                165                 170                 175     


Gln Val Lys Asn Ser Pro Arg Glu Ala Val Asn Phe Arg Arg Val Phe 
            180                 185                 190         


Glu Trp Glu Leu Phe Gly Ile Ala Leu Lys Gln Ala Phe Gly Lys Asp 
        195                 200                 205             


Ile Glu Lys Pro Ile Tyr Val Glu Glu Leu Gly Thr Thr Leu Ser Arg 
    210                 215                 220                 


Asp Glu Ile Phe Lys Val Leu Val Leu Asp Ile Met Glu Gly Ala Ile 
225                 230                 235                 240 


Glu Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Arg Trp Ile Pro Asn 
                245                 250                 255     


Thr Arg Met Glu Thr Lys Ile Gln Arg Leu Tyr Phe Arg Arg Lys Ala 
            260                 265                 270         


Val Met Thr Ala Leu Ile Asn Glu Gln Lys Lys Arg Ile Ala Ser Gly 
        275                 280                 285             


Glu Glu Ile Asn Cys Tyr Ile Asp Phe Leu Leu Lys Glu Gly Lys Thr 
    290                 295                 300                 


Leu Thr Met Asp Gln Ile Ser Met Leu Leu Trp Glu Thr Val Ile Glu 
305                 310                 315                 320 


Thr Ala Asp Thr Thr Met Val Thr Thr Glu Trp Ala Met Tyr Glu Val 
                325                 330                 335     


Ala Lys Asp Ser Lys Arg Gln Asp Arg Leu Tyr Gln Glu Ile Gln Lys 
            340                 345                 350         


Val Cys Gly Ser Glu Met Val Thr Glu Glu Tyr Leu Ser Gln Leu Pro 
        355                 360                 365             


Tyr Leu Asn Ala Val Phe His Glu Thr Leu Arg Lys His Ser Pro Ala 
    370                 375                 380                 


Ala Leu Val Pro Leu Arg Tyr Ala His Glu Asp Thr Gln Leu Gly Gly 
385                 390                 395                 400 


Tyr Tyr Ile Pro Ala Gly Thr Glu Ile Ala Ile Asn Ile Tyr Gly Cys 
                405                 410                 415     


Asn Met Asp Lys His Gln Trp Glu Ser Pro Glu Glu Trp Lys Pro Glu 
            420                 425                 430         


Arg Phe Leu Asp Pro Lys Phe Asp Pro Met Asp Leu Tyr Lys Thr Met 
        435                 440                 445             


Ala Phe Gly Ala Gly Lys Arg Val Cys Ala Gly Ser Leu Gln Ala Met 
    450                 455                 460                 


Leu Ile Ala Cys Pro Thr Ile Gly Arg Leu Val Gln Glu Phe Glu Trp 
465                 470                 475                 480 


Lys Leu Arg Asp Gly Glu Glu Glu Asn Val Asp Thr Val Gly Leu Thr 
                485                 490                 495     


Thr His Lys Arg Tyr Pro Met His Ala Ile Leu Lys Pro Arg Ser Pro 
            500                 505                 510         


Ser Arg Pro Ser Pro Ser Thr Glu Gln Ser Ala Lys Lys Val Arg Lys 
        515                 520                 525             


Lys Ala Glu Asn Ala His Asn Thr Pro Leu Leu Val Leu Tyr Gly Ser 
    530                 535                 540                 


Asn Met Gly Thr Ala Glu Gly Thr Ala Arg Asp Leu Ala Asp Ile Ala 
545                 550                 555                 560 


Met Ser Lys Gly Phe Ala Pro Gln Val Ala Thr Leu Asp Ser His Ala 
                565                 570                 575     


Gly Asn Leu Pro Arg Glu Gly Ala Val Leu Ile Val Thr Ala Ser Tyr 
            580                 585                 590         


Asn Gly His Pro Pro Asp Asn Ala Lys Gln Phe Val Asp Trp Leu Asp 
        595                 600                 605             


Gln Ala Ser Ala Asp Glu Val Lys Gly Val Arg Tyr Ser Val Phe Gly 
    610                 615                 620                 


Cys Gly Asp Lys Asn Trp Ala Thr Thr Tyr Gln Lys Val Pro Ala Phe 
625                 630                 635                 640 


Ile Asp Glu Met Leu Ala Ala Lys Gly Ala Glu Asn Ile Ala Asp Arg 
                645                 650                 655     


Gly Glu Ala Asp Ala Ser Asp Asp Phe Glu Gly Thr Tyr Glu Glu Trp 
            660                 665                 670         


Arg Glu His Met Trp Ser Asp Val Ala Ala Tyr Phe Asn Leu Asp Ile 
        675                 680                 685             


Glu Asn Ser Glu Asp Asn Lys Ser Ala Leu Leu Leu Gln Phe Val Asp 
    690                 695                 700                 


Ser Ala Ala Asp Met Pro Leu Ala Lys Met His Gly Ala Phe Ser Thr 
705                 710                 715                 720 


Asn Val Val Ala Ser Lys Glu Leu Gln Gln Pro Gly Ser Ala Arg Ser 
                725                 730                 735     


Thr Arg His Leu Glu Ile Glu Leu Pro Lys Glu Ala Ser Tyr Gln Glu 
            740                 745                 750         


Gly Asp His Leu Gly Val Ile Pro Arg Asn Tyr Glu Gly Ile Val Asn 
        755                 760                 765             


Arg Val Thr Ala Arg Phe Gly Leu Asp Ala Ser Gln Gln Ile Arg Leu 
    770                 775                 780                 


Glu Ala Glu Glu Glu Lys Leu Ala His Leu Pro Leu Ala Lys Thr Val 
785                 790                 795                 800 


Ser Val Glu Glu Leu Leu Gln Tyr Val Glu Leu Gln Asp Pro Val Thr 
                805                 810                 815     


Arg Thr Gln Leu Arg Ala Met Ala Ala Lys Thr Val Cys Pro Pro His 
            820                 825                 830         


Lys Val Glu Leu Glu Ala Leu Leu Glu Lys Gln Ala Tyr Lys Glu Gln 
        835                 840                 845             


Val Leu Ala Lys Arg Leu Thr Met Leu Glu Leu Leu Glu Lys Tyr Pro 
    850                 855                 860                 


Ala Cys Glu Met Glu Phe Ser Glu Phe Ile Ala Leu Leu Pro Ser Ile 
865                 870                 875                 880 


Arg Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Val Asp Glu Lys 
                885                 890                 895     


Gln Ala Ser Ile Thr Val Ser Val Val Ser Gly Glu Ala Trp Ser Gly 
            900                 905                 910         


Tyr Gly Glu Tyr Lys Gly Ile Ala Ser Asn Tyr Leu Ala Glu Leu Gln 
        915                 920                 925             


Glu Gly Asp Thr Ile Thr Cys Phe Ile Ser Thr Pro Gln Ser Glu Phe 
    930                 935                 940                 


Thr Leu Pro Lys Asp Pro Glu Thr Pro Leu Ile Met Val Gly Pro Gly 
945                 950                 955                 960 


Thr Gly Val Ala Pro Phe Arg Gly Phe Val Gln Ala Arg Lys Gln Leu 
                965                 970                 975     


Lys Glu Gln Gly Gln Ser Leu Gly Glu Ala His Leu Tyr Phe Gly Cys 
            980                 985                 990         


Arg Ser Pro His Glu Asp Tyr Leu  Tyr Gln Glu Glu Leu  Glu Asn Ala 
        995                 1000                 1005             


Gln Ser  Glu Gly Ile Ile Thr  Leu His Thr Ala Phe  Ser Arg Met 
    1010                 1015                 1020             


Pro Asn  Gln Pro Lys Thr Tyr  Val Gln His Val Met  Glu Gln Asp 
    1025                 1030                 1035             


Gly Lys  Lys Leu Ile Glu Leu  Leu Asp Lys Gly Ala  His Phe Tyr 
    1040                 1045                 1050             


Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro Ala Val  Glu Ala Thr 
    1055                 1060                 1065             


Leu Met  Lys Ser Tyr Ala Asp  Val His Gln Val Ser  Glu Ala Asp 
    1070                 1075                 1080             


Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu Lys Gly  Arg Tyr Ala 
    1085                 1090                 1095             


Lys Asp  Val Ala 
    1100         


<210>  111
<211>  3165
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  111
atggttccag gtttgccagt tattggtaat ttgttgcaat tgaaagaaaa gaagccatac       60

caaaccttca ctagatgggc tgaagaatat ggtccaatct actctattag aactggtgct      120

tctactatgg ttgtcttgaa cactactcaa gttgccaaag aagctatggt taccagatac      180

ttgtctatct ctaccagaaa gttgtccaac gccttgaaaa ttttgaccgc tgataagtgc      240

atggttgcca tttctgatta caacgatttc cacaagatga tcaagagata tatcttgtct      300

aacgttttgg gtccatctgc ccaaaaaaga catagatcta acagagatac cttgagagcc      360

aacgtttgtt ctagattgca ttcccaagtt aagaactctc caagagaagc tgtcaacttt      420

agaagagttt tcgaatggga attattcggt atcgctttga aacaagcctt cggtaaggat      480

attgaaaagc caatctacgt cgaagaattg ggtactactt tgtccagaga tgaaatcttc      540

aaggttttgg tcttggacat tatggaaggt gccattgaag ttgattggag agattttttc      600

ccatacttgc gttggattcc aaacaccaga atggaaacta agatccaaag attatacttt      660

agaagaaagg ccgttatgac cgccttgatt aacgaacaaa agaaaagaat tgcctccggt      720

gaagaaatca actgctacat cgatttcttg ttgaaagaag gtaagacctt gaccatggac      780

caaatctcta tgttgttgtg ggaaaccgtt attgaaactg ctgataccac aatggttact      840

actgaatggg ctatgtacga agttgctaag gattctaaaa gacaagacag attataccaa      900

gaaatccaaa aggtctgcgg ttctgaaatg gttacagaag aatacttgtc ccaattgcca      960

tacttgaatg ctgttttcca cgaaactttg agaaaacatt ctccagctgc tttggttcca     1020

ttgagatatg ctcatgaaga tactcaattg ggtggttatt acattccagc cggtactgaa     1080

attgccatta acatctacgg ttgcaacatg gacaaacacc aatgggaatc tccagaagaa     1140

tggaagccag aaagattttt ggatcctaag tttgacccaa tggacttgta caaaactatg     1200

gcttttggtg ctggtaaaag agtttgcgct ggttctttac aagctatgtt gattgcttgt     1260

ccaaccatcg gtagattggt tcaagaattt gaatggaagt tgagagatgg tgaagaagaa     1320

aacgttgata ctgttggttt gaccacccat aagagatatc caatgcatgc tattttgaag     1380

ccaagatctc catcaagacc aagtcctagt accgaacaat ctgcaaaaaa agttagaaaa     1440

aaagcagaaa atgcacacaa tactccattg ctagttcttt atggttctaa tatgggaaca     1500

gcggaaggaa cggccaggga tctagctgac atagctatgt ccaagggatt tgccccgcaa     1560

gtagcaaccc tggattccca tgcaggtaac ttgccaagag aaggtgctgt tctaatagtt     1620

accgctagct acaatgggca ccctccagat aatgcgaagc agttcgtcga ttggttagat     1680

caagcatcag cagatgaagt taagggtgtt agatactctg tttttggatg tggagataag     1740

aattgggcca ccacatatca gaaggttccg gctttcatcg atgaaatgct tgctgcaaaa     1800

ggggctgaaa atatagcaga tcgtggtgag gccgacgcaa gcgacgattt tgagggtacc     1860

tatgaggagt ggagagagca catgtggtct gatgttgccg cgtattttaa tctagacata     1920

gaaaattctg aagacaataa aagtgcctta cttcttcaat tcgtcgatag tgctgcggac     1980

atgcccttag caaagatgca tggagccttt tcaacgaacg tagtagccag taaggaactt     2040

caacaaccag gtagtgccag aagtacacgt cacttggaaa ttgaattacc aaaagaggca     2100

tcctaccaag aaggtgacca tcttggtgta atcccaagaa actacgaagg tatagtcaat     2160

agggtaacgg caagatttgg gctggatgca agccaacaga taagactaga agcagaagaa     2220

gaaaaattgg cgcaccttcc actagcgaag acagtatccg ttgaagaatt attgcaatac     2280

gtggaattgc aggatcccgt cactagaacg caattgagag ctatggcagc aaagactgtt     2340

tgtccacctc acaaggttga acttgaagct ctacttgaaa aacaagcata caaagagcaa     2400

gtgctagcaa agagactaac catgttagaa ttgctggaaa aatacccggc atgcgaaatg     2460

gaattctccg aatttatcgc gttgttgcca agtattcgtc ccaggtatta ctcaatttca     2520

tcttcaccaa gggttgacga gaaacaggca tctattaccg tatctgtggt ctctggagaa     2580

gcttggagtg gttacggaga atacaagggt attgcttcca attatcttgc agaactgcag     2640

gaaggggata caattacctg ctttatttct actcctcaat cagaatttac tcttccgaag     2700

gatccagaaa ctccgttaat tatggtaggt ccgggaacag gagtcgcccc tttcagaggc     2760

tttgtgcaag caaggaagca actaaaagaa cagggacaaa gtctgggtga ggcacatcta     2820

tatttcggtt gcagatctcc gcatgaggat tacttatacc aagaagaact tgaaaacgcc     2880

caatcagaag gtattatcac cttgcatact gcattcagta gaatgccaaa ccagccgaaa     2940

acttacgtac agcatgttat ggagcaagat ggtaagaagt taattgagct tttggataag     3000

ggcgcccact tctacatttg cggcgacgga tcccaaatgg cgcctgccgt tgaagccacc     3060

ttgatgaaat catatgcaga tgttcatcaa gtttcagaag cggacgcccg tctttggtta     3120

caacaactag aggagaaagg aaggtatgca aaagatgttg cttaa                     3165


<210>  112
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KO-BMR fusion construct

<400>  112

Met Val Pro Gly Leu Pro Val Ile Gly Asn Leu Leu Gln Leu Lys Glu 
1               5                   10                  15      


Lys Lys Pro Tyr Gln Thr Phe Thr Arg Trp Ala Glu Glu Tyr Gly Pro 
            20                  25                  30          


Ile Tyr Ser Ile Arg Thr Gly Ala Ser Thr Met Val Val Leu Asn Thr 
        35                  40                  45              


Thr Gln Val Ala Lys Glu Ala Met Val Thr Arg Tyr Leu Ser Ile Ser 
    50                  55                  60                  


Thr Arg Lys Leu Ser Asn Ala Leu Lys Ile Leu Thr Ala Asp Lys Cys 
65                  70                  75                  80  


Met Val Ala Ile Ser Asp Tyr Asn Asp Phe His Lys Met Ile Lys Arg 
                85                  90                  95      


Tyr Ile Leu Ser Asn Val Leu Gly Pro Ser Ala Gln Lys Arg His Arg 
            100                 105                 110         


Ser Asn Arg Asp Thr Leu Arg Ala Asn Val Cys Ser Arg Leu His Ser 
        115                 120                 125             


Gln Val Lys Asn Ser Pro Arg Glu Ala Val Asn Phe Arg Arg Val Phe 
    130                 135                 140                 


Glu Trp Glu Leu Phe Gly Ile Ala Leu Lys Gln Ala Phe Gly Lys Asp 
145                 150                 155                 160 


Ile Glu Lys Pro Ile Tyr Val Glu Glu Leu Gly Thr Thr Leu Ser Arg 
                165                 170                 175     


Asp Glu Ile Phe Lys Val Leu Val Leu Asp Ile Met Glu Gly Ala Ile 
            180                 185                 190         


Glu Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Arg Trp Ile Pro Asn 
        195                 200                 205             


Thr Arg Met Glu Thr Lys Ile Gln Arg Leu Tyr Phe Arg Arg Lys Ala 
    210                 215                 220                 


Val Met Thr Ala Leu Ile Asn Glu Gln Lys Lys Arg Ile Ala Ser Gly 
225                 230                 235                 240 


Glu Glu Ile Asn Cys Tyr Ile Asp Phe Leu Leu Lys Glu Gly Lys Thr 
                245                 250                 255     


Leu Thr Met Asp Gln Ile Ser Met Leu Leu Trp Glu Thr Val Ile Glu 
            260                 265                 270         


Thr Ala Asp Thr Thr Met Val Thr Thr Glu Trp Ala Met Tyr Glu Val 
        275                 280                 285             


Ala Lys Asp Ser Lys Arg Gln Asp Arg Leu Tyr Gln Glu Ile Gln Lys 
    290                 295                 300                 


Val Cys Gly Ser Glu Met Val Thr Glu Glu Tyr Leu Ser Gln Leu Pro 
305                 310                 315                 320 


Tyr Leu Asn Ala Val Phe His Glu Thr Leu Arg Lys His Ser Pro Ala 
                325                 330                 335     


Ala Leu Val Pro Leu Arg Tyr Ala His Glu Asp Thr Gln Leu Gly Gly 
            340                 345                 350         


Tyr Tyr Ile Pro Ala Gly Thr Glu Ile Ala Ile Asn Ile Tyr Gly Cys 
        355                 360                 365             


Asn Met Asp Lys His Gln Trp Glu Ser Pro Glu Glu Trp Lys Pro Glu 
    370                 375                 380                 


Arg Phe Leu Asp Pro Lys Phe Asp Pro Met Asp Leu Tyr Lys Thr Met 
385                 390                 395                 400 


Ala Phe Gly Ala Gly Lys Arg Val Cys Ala Gly Ser Leu Gln Ala Met 
                405                 410                 415     


Leu Ile Ala Cys Pro Thr Ile Gly Arg Leu Val Gln Glu Phe Glu Trp 
            420                 425                 430         


Lys Leu Arg Asp Gly Glu Glu Glu Asn Val Asp Thr Val Gly Leu Thr 
        435                 440                 445             


Thr His Lys Arg Tyr Pro Met His Ala Ile Leu Lys Pro Arg Ser Pro 
    450                 455                 460                 


Ser Arg Pro Ser Pro Ser Thr Glu Gln Ser Ala Lys Lys Val Arg Lys 
465                 470                 475                 480 


Lys Ala Glu Asn Ala His Asn Thr Pro Leu Leu Val Leu Tyr Gly Ser 
                485                 490                 495     


Asn Met Gly Thr Ala Glu Gly Thr Ala Arg Asp Leu Ala Asp Ile Ala 
            500                 505                 510         


Met Ser Lys Gly Phe Ala Pro Gln Val Ala Thr Leu Asp Ser His Ala 
        515                 520                 525             


Gly Asn Leu Pro Arg Glu Gly Ala Val Leu Ile Val Thr Ala Ser Tyr 
    530                 535                 540                 


Asn Gly His Pro Pro Asp Asn Ala Lys Gln Phe Val Asp Trp Leu Asp 
545                 550                 555                 560 


Gln Ala Ser Ala Asp Glu Val Lys Gly Val Arg Tyr Ser Val Phe Gly 
                565                 570                 575     


Cys Gly Asp Lys Asn Trp Ala Thr Thr Tyr Gln Lys Val Pro Ala Phe 
            580                 585                 590         


Ile Asp Glu Met Leu Ala Ala Lys Gly Ala Glu Asn Ile Ala Asp Arg 
        595                 600                 605             


Gly Glu Ala Asp Ala Ser Asp Asp Phe Glu Gly Thr Tyr Glu Glu Trp 
    610                 615                 620                 


Arg Glu His Met Trp Ser Asp Val Ala Ala Tyr Phe Asn Leu Asp Ile 
625                 630                 635                 640 


Glu Asn Ser Glu Asp Asn Lys Ser Ala Leu Leu Leu Gln Phe Val Asp 
                645                 650                 655     


Ser Ala Ala Asp Met Pro Leu Ala Lys Met His Gly Ala Phe Ser Thr 
            660                 665                 670         


Asn Val Val Ala Ser Lys Glu Leu Gln Gln Pro Gly Ser Ala Arg Ser 
        675                 680                 685             


Thr Arg His Leu Glu Ile Glu Leu Pro Lys Glu Ala Ser Tyr Gln Glu 
    690                 695                 700                 


Gly Asp His Leu Gly Val Ile Pro Arg Asn Tyr Glu Gly Ile Val Asn 
705                 710                 715                 720 


Arg Val Thr Ala Arg Phe Gly Leu Asp Ala Ser Gln Gln Ile Arg Leu 
                725                 730                 735     


Glu Ala Glu Glu Glu Lys Leu Ala His Leu Pro Leu Ala Lys Thr Val 
            740                 745                 750         


Ser Val Glu Glu Leu Leu Gln Tyr Val Glu Leu Gln Asp Pro Val Thr 
        755                 760                 765             


Arg Thr Gln Leu Arg Ala Met Ala Ala Lys Thr Val Cys Pro Pro His 
    770                 775                 780                 


Lys Val Glu Leu Glu Ala Leu Leu Glu Lys Gln Ala Tyr Lys Glu Gln 
785                 790                 795                 800 


Val Leu Ala Lys Arg Leu Thr Met Leu Glu Leu Leu Glu Lys Tyr Pro 
                805                 810                 815     


Ala Cys Glu Met Glu Phe Ser Glu Phe Ile Ala Leu Leu Pro Ser Ile 
            820                 825                 830         


Arg Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Val Asp Glu Lys 
        835                 840                 845             


Gln Ala Ser Ile Thr Val Ser Val Val Ser Gly Glu Ala Trp Ser Gly 
    850                 855                 860                 


Tyr Gly Glu Tyr Lys Gly Ile Ala Ser Asn Tyr Leu Ala Glu Leu Gln 
865                 870                 875                 880 


Glu Gly Asp Thr Ile Thr Cys Phe Ile Ser Thr Pro Gln Ser Glu Phe 
                885                 890                 895     


Thr Leu Pro Lys Asp Pro Glu Thr Pro Leu Ile Met Val Gly Pro Gly 
            900                 905                 910         


Thr Gly Val Ala Pro Phe Arg Gly Phe Val Gln Ala Arg Lys Gln Leu 
        915                 920                 925             


Lys Glu Gln Gly Gln Ser Leu Gly Glu Ala His Leu Tyr Phe Gly Cys 
    930                 935                 940                 


Arg Ser Pro His Glu Asp Tyr Leu Tyr Gln Glu Glu Leu Glu Asn Ala 
945                 950                 955                 960 


Gln Ser Glu Gly Ile Ile Thr Leu His Thr Ala Phe Ser Arg Met Pro 
                965                 970                 975     


Asn Gln Pro Lys Thr Tyr Val Gln His Val Met Glu Gln Asp Gly Lys 
            980                 985                 990         


Lys Leu Ile Glu Leu Leu Asp Lys  Gly Ala His Phe Tyr  Ile Cys Gly 
        995                 1000                 1005             


Asp Gly  Ser Gln Met Ala Pro  Ala Val Glu Ala Thr  Leu Met Lys 
    1010                 1015                 1020             


Ser Tyr  Ala Asp Val His Gln  Val Ser Glu Ala Asp  Ala Arg Leu 
    1025                 1030                 1035             


Trp Leu  Gln Gln Leu Glu Glu  Lys Gly Arg Tyr Ala  Lys Asp Val 
    1040                 1045                 1050             


Ala 
    


<210>  113
<211>  1476
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  113
atgaccagtt tgtccaaaag cttcatgcag agtggacgaa tctgcgcagc atgtttctat       60

ctgttattca cactactttc aattccaatc tcgtttaaag ttggtggttt ggaatgcggg      120

ctttccttca cggtgacact gttcacttta tatttcataa ctacgactct taacgtgttg      180

gcaagacgac atggaggaag actatacatt ttttttacca actgtctgta ttactcacaa      240

cattttatca ttgcatcttt gctatacctg tttttgtctg gattttctaa tgatgagttg      300

ggaaacgttc tgaaaaataa atataatgag tcggagtcgt tcctggaagc tttgaaaaat      360

agcttgaatt ccaatcaaat taactacgtc ttatattatt actactatcg atttgttgta      420

caaccgtggc aattcgtgct taccaagtcc acaccttttt ttactctatc ggaaggtttt      480

ttcactattt tagccattca ggccgtcggg gaaactaata gatggttatc aaatgacttg      540

aattcaaaca cgtggattat ttcctcattg ttaacctccg gaggtgtgat taccgcatcg      600

ctgtactatt tgtatcggat ttatgtcacc cccatatggc cgttatccat ccaaacggcg      660

tccttattag gacttgtttt gtctatggta tgtggactgg ggttgtatgg tattgtgagt      720

caaaaaggat ccgtcataga gagctcttta ttttttgcgt atattgttcg ttgtatttat      780

gaaatttccc ccaaattagc tactaccgcg actgatgaaa ttttaaattt gttcaaagac      840

gtctggcaga aacatcaaag aaatctgccc acagctgaca atcttttgtg ctactttcat      900

aatgtcatat tgaaaaatgc agaggtgtta tgggggtcct ttattcctag aggaagaaag      960

aaaaccggtg attttcatga taaactcatt agcattctat cattcgaaaa agtatccttg     1020

atatctaaac cattttggaa atttttcaag aatttcacct ttagtgttcc gctatccatt     1080

aatgaatttt gtcaagttac aattaagatg gcaagcgaat cagtttcccc agctatagta     1140

atcaatttat gctttagagt tctgatgttt tactcggcaa cgaggattat tccagcatta     1200

caaagaaaaa atgacaaaca gttgcgcaag agtcgcagga tcatgaaggg attgtattgg     1260

tacagtcctt gcatattaat tgctatgtat actcacctga ttttacaata ttcaggtgag     1320

ctaaagaaag acctgtgcat atggggttgc agtgaaaagt ggtttggcgt agatcaacca     1380

gaaattatag tagattcatg gggattttgg aactggtgca acattttctg tactattttg     1440

gtatacgcta cagaattaat aggttctggt agttga                               1476


<210>  114
<211>  491
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  114

Met Thr Ser Leu Ser Lys Ser Phe Met Gln Ser Gly Arg Ile Cys Ala 
1               5                   10                  15      


Ala Cys Phe Tyr Leu Leu Phe Thr Leu Leu Ser Ile Pro Ile Ser Phe 
            20                  25                  30          


Lys Val Gly Gly Leu Glu Cys Gly Leu Ser Phe Thr Val Thr Leu Phe 
        35                  40                  45              


Thr Leu Tyr Phe Ile Thr Thr Thr Leu Asn Val Leu Ala Arg Arg His 
    50                  55                  60                  


Gly Gly Arg Leu Tyr Ile Phe Phe Thr Ser Cys Leu Tyr Tyr Ser Gln 
65                  70                  75                  80  


His Phe Ile Ile Ala Ser Leu Leu Tyr Leu Phe Leu Ser Gly Phe Ser 
                85                  90                  95      


Asn Asp Glu Leu Gly Asn Val Leu Lys Asn Lys Tyr Asn Glu Ser Glu 
            100                 105                 110         


Ser Phe Leu Glu Ala Leu Lys Asn Ser Leu Asn Ser Asn Gln Ile Asn 
        115                 120                 125             


Tyr Val Leu Tyr Tyr Tyr Tyr Tyr Arg Phe Val Val Gln Pro Trp Gln 
    130                 135                 140                 


Phe Val Leu Thr Lys Ser Thr Pro Phe Phe Thr Leu Ser Glu Gly Phe 
145                 150                 155                 160 


Phe Thr Ile Leu Ala Ile Gln Ala Val Gly Glu Thr Asn Arg Trp Leu 
                165                 170                 175     


Ser Asn Asp Leu Asn Ser Asn Thr Trp Ile Ile Ser Ser Leu Leu Thr 
            180                 185                 190         


Ser Gly Gly Val Ile Thr Ala Ser Leu Tyr Tyr Leu Tyr Arg Ile Tyr 
        195                 200                 205             


Val Thr Pro Ile Trp Pro Leu Ser Ile Gln Thr Ala Ser Leu Leu Gly 
    210                 215                 220                 


Phe Val Leu Ser Met Val Cys Gly Leu Gly Leu Tyr Gly Ile Val Ser 
225                 230                 235                 240 


Gln Lys Gly Ser Val Ile Glu Ser Ser Leu Phe Phe Ala Tyr Ile Val 
                245                 250                 255     


Arg Cys Ile Tyr Glu Ile Ser Pro Lys Leu Ala Thr Thr Ala Thr Asp 
            260                 265                 270         


Glu Ile Leu Asn Leu Phe Lys Asp Val Trp Gln Lys His Gln Arg Asn 
        275                 280                 285             


Leu Pro Thr Ala Asp Asn Leu Leu Cys Tyr Phe His Asn Val Ile Leu 
    290                 295                 300                 


Lys Asn Ala Glu Val Leu Trp Gly Ser Phe Ile Pro Arg Gly Arg Lys 
305                 310                 315                 320 


Lys Thr Gly Asp Phe His Asp Lys Leu Ile Ser Ile Leu Ser Phe Glu 
                325                 330                 335     


Lys Val Ser Leu Ile Ser Lys Pro Phe Trp Lys Phe Phe Lys Asn Phe 
            340                 345                 350         


Thr Phe Ser Val Pro Leu Ser Ile Asn Glu Phe Cys Gln Val Thr Ile 
        355                 360                 365             


Lys Met Ala Ser Glu Ser Val Ser Pro Ala Ile Val Ile Asn Leu Cys 
    370                 375                 380                 


Phe Arg Val Leu Met Phe Tyr Ser Ala Thr Arg Ile Ile Pro Ala Leu 
385                 390                 395                 400 


Gln Arg Lys Asn Asp Lys Gln Leu Arg Lys Ser Arg Arg Ile Met Lys 
                405                 410                 415     


Gly Leu Tyr Trp Tyr Ser Pro Cys Ile Leu Ile Ala Met Tyr Thr His 
            420                 425                 430         


Leu Ile Leu Gln Tyr Ser Gly Glu Leu Lys Lys Asp Leu Cys Ile Trp 
        435                 440                 445             


Gly Cys Ser Glu Lys Trp Phe Gly Val Asp Gln Pro Glu Ile Ile Val 
    450                 455                 460                 


Asp Ser Trp Gly Phe Trp Asn Trp Cys Asn Ile Phe Cys Thr Ile Leu 
465                 470                 475                 480 


Val Tyr Ala Thr Glu Leu Ile Gly Ser Gly Ser 
                485                 490     


<210>  115
<211>  4957
<212>  DNA
<213>  Bacillus megaterium

<400>  115
agatctttat gaagacatag ctgcagaaga aaaagcaaga gctacatatc aatggttaat       60

tgatatatca gatgatcccg atttaaacga cagcttacga tttttacgag aaagagagat      120

tgttcactca cagcggttcc gcgaggccgt ggagatttta aaagatgaca gagacaggaa      180

gaaaatcttt taactagtaa aaaaacatcc cccttggcga atgcaaacga aaggagggat      240

gttttttgtt gtgactgcgt tgattatgcg ctagaactgc agtgacaaga aacaaccttt      300

aatttccctt caacatcttt ccaaactcgc gtataactgt attcacctcc aatagattca      360

ccggttgcca gtgccccatt taacgctact tttgtaacgg taacggcaag ttcttgaaac      420

agtttaactt cttgttccaa cacttccatg cccgctatat caagactttt tgaacgatga      480

acatttatat cttcttcttt tgacaaccat tgcccaaggt gattcacaaa aataagctca      540

tctgaaagta attcttctaa tagctctatg ttattagaaa gcatggctga gcgaagcatt      600

tcttcgtatt ctataactct tgcttgattc atttttaatc ctcctttacg ccttgtgtaa      660

ctcttttcta tttccacgtt gcttttcctt taaacttctt tcattaataa ttcgtgctaa      720

attatgttaa tagaggggat aagtggacta attttctgta agcactaaat attctgaaat      780

actctgttaa ttacctttaa atggtataaa attagaatga aagaaccttt tctttccact      840

tttctagtta tctttttact attaagatgc agttttttat acttgtaatt gtagcggaat      900

gaacgttcat tccgtttttg aaaagaggtg ataaagtgga atctactcca acaaaacaaa      960

aagcgatttt ttctgcttcg cttctgctgt ttgcagaaag agggtttgat gcaaccacga     1020

tgccaatgat tgcagagaat gccaaagtag gagcaggaac aatttatcgc tactttaaaa     1080

ataaagaaag ccttgtaaat gaattattcc aacagcacgt aaacgagttt ttacagtgca     1140

ttgaaagcgg tctggcaaac gagagagatg gataccgaga tgggtttcat catatctttg     1200

aaggtatggt gacatttact aaaaaccatc ctcgtgctct tggatttatt aaaactcata     1260

gccaaggaac ttttttaaca gaagagagcc gcttagcata tcaaaagctg gtggaatttg     1320

tttgtacgtt cttcagagaa ggacaaaagc aaggtgtgat tagaaatctt cctgaaaatg     1380

cgctaattgc tattttattt ggaagtttca tggaagtata tgaaatgatt gaaaatgact     1440

acttatcttt aactgatgaa cttcttaccg gtgtagaaga gagtctgtgg gcagcactta     1500

gcagacaatc atgaaactta acaagtgaaa gagggataac atgacaatta aagaaatgcc     1560

tcagccaaaa acgtttggag agcttaaaaa tttaccgtta ttaaacacag ataaaccggt     1620

tcaagctttg atgaaaattg cggatgaatt aggagaaatc tttaaattcg aggcgcctgg     1680

tcgtgtaacg cgctacttat caagtcagcg tctaattaaa gaagcatgcg atgaatcacg     1740

ctttgataaa aacttaagtc aagcgcttaa atttgtacgt gattttgcag gagacgggtt     1800

atttacaagc tggacgcatg aaaaaaattg gaaaaaagcg cataatatct tacttccaag     1860

cttcagtcag caggcaatga aaggctatca tgcgatgatg gtcgatatcg ccgtgcagct     1920

tgttcaaaag tgggagcgtc taaatgcaga tgagcatatt gaagtaccgg aagacatgac     1980

acgtttaacg cttgatacaa ttggtctttg cggctttaac tatcgcttta acagctttta     2040

ccgagatcag cctcatccat ttattacaag tatggtccgt gcactggatg aagcaatgaa     2100

caagctgcag cgagcaaatc cagacgaccc agcttatgat gaaaacaagc gccagtttca     2160

agaagatatc aaggtgatga acgacctagt agataaaatt attgcagatc gcaaagcaag     2220

cggtgaacaa agcgatgatt tattaacgca tatgctaaac ggaaaagatc cagaaacggg     2280

tgagccgctt gatgacgaga acattcgcta tcaaattatt acattcttaa ttgcgggaca     2340

cgaaacaaca agtggtcttt tatcatttgc gctgtatttc ttagtgaaaa atccacatgt     2400

attacaaaaa gcagcagaag aagcagcacg agttctagta gatcctgttc caagctacaa     2460

acaagtcaaa cagcttaaat atgtcggcat ggtcttaaac gaagcgctgc gcttatggcc     2520

aactgctcct gcgttttccc tatatgcaaa agaagatacg gtgcttggag gagaatatcc     2580

tttagaaaaa ggcgacgaac taatggttct gattcctcag cttcaccgtg ataaaacaat     2640

ttggggagac gatgtggaag agttccgtcc agagcgtttt gaaaatccaa gtgcgattcc     2700

gcagcatgcg tttaaaccgt ttggaaacgg tcagcgtgcg tgtatcggtc agcagttcgc     2760

tcttcatgaa gcaacgctgg tacttggtat gatgctaaaa cactttgact ttgaagatca     2820

tacaaactac gagctggata ttaaagaaac tttaacgtta aaacctgaag gctttgtggt     2880

aaaagcaaaa tcgaaaaaaa ttccgcttgg cggtattcct tcacctagca ctgaacagtc     2940

tgctaaaaaa gtacgcaaaa aggcagaaaa cgctcataat acgccgctgc ttgtgctata     3000

cggttcaaat atgggaacag ctgaaggaac ggcgcgtgat ttagcagata ttgcaatgag     3060

caaaggattt gcaccgcagg tcgcaacgct tgattcacac gccggaaatc ttccgcgcga     3120

aggagctgta ttaattgtaa cggcgtctta taacggtcat ccgcctgata acgcaaagca     3180

atttgtcgac tggttagacc aagcgtctgc tgatgaagta aaaggcgttc gctactccgt     3240

atttggatgc ggcgataaaa actgggctac tacgtatcaa aaagtgcctg cttttatcga     3300

tgaaacgctt gccgctaaag gggcagaaaa catcgctgac cgcggtgaag cagatgcaag     3360

cgacgacttt gaaggcacat atgaagaatg gcgtgaacat atgtggagtg acgtagcagc     3420

ctactttaac ctcgacattg aaaacagtga agataataaa tctactcttt cacttcaatt     3480

tgtcgacagc gccgcggata tgccgcttgc gaaaatgcac ggtgcgtttt caacgaacgt     3540

cgtagcaagc aaagaacttc aacagccagg cagtgcacga agcacgcgac atcttgaaat     3600

tgaacttcca aaagaagctt cttatcaaga aggagatcat ttaggtgtta ttcctcgcaa     3660

ctatgaagga atagtaaacc gtgtaacagc aaggttcggc ctagatgcat cacagcaaat     3720

ccgtctggaa gcagaagaag aaaaattagc tcatttgcca ctcgctaaaa cagtatccgt     3780

agaagagctt ctgcaatacg tggagcttca agatcctgtt acgcgcacgc agcttcgcgc     3840

aatggctgct aaaacggtct gcccgccgca taaagtagag cttgaagcct tgcttgaaaa     3900

gcaagcctac aaagaacaag tgctggcaaa acgtttaaca atgcttgaac tgcttgaaaa     3960

atacccggcg tgtgaaatga aattcagcga atttatcgcc cttctgccaa gcatacgccc     4020

gcgctattac tcgatttctt catcacctcg tgtcgatgaa aaacaagcaa gcatcacggt     4080

cagcgttgtc tcaggagaag cgtggagcgg atatggagaa tataaaggaa ttgcgtcgaa     4140

ctatcttgcc gagctgcaag aaggagatac gattacgtgc tttatttcca caccgcagtc     4200

agaatttacg ctgccaaaag accctgaaac gccgcttatc atggtcggac cgggaacagg     4260

cgtcgcgccg tttagaggct ttgtgcaggc gcgcaaacag ctaaaagaac aaggacagtc     4320

acttggagaa gcacatttat acttcggctg ccgttcacct catgaagact atctgtatca     4380

agaagagctt gaaaacgccc aaagcgaagg catcattacg cttcataccg ctttttctcg     4440

catgccaaat cagccgaaaa catacgttca gcacgtaatg gaacaagacg gcaagaaatt     4500

gattgaactt cttgatcaag gagcgcactt ctatatttgc ggagacggaa gccaaatggc     4560

acctgccgtt gaagcaacgc ttatgaaaag ctatgctgac gttcaccaag tgagtgaagc     4620

agacgctcgc ttatggctgc agcagctaga agaaaaaggc cgatacgcaa aagacgtgtg     4680

ggctgggtaa attaaaaaga ggctaggata aaagtagttt agttggttga aggaagatcc     4740

gaacgatgaa tcgttcggat ctttttattg gtagagtaaa cgtagatttc atctatttag     4800

tgacttgtag cggttgattg gagggcaagg tgaagactcc aatcaaccgc ggtgtcacat     4860

gcaagccata cgaaattcat ttctcccatt tattcgtctt ttgtccccac ttaattttta     4920

tagcgcctta acgtttcttc tgcgtgacag cagatct                              4957


<210>  116
<211>  1049
<212>  PRT
<213>  Bacillus megaterium

<400>  116

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Val Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  117
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized BMR

<400>  117
ccaagtccta gtaccgaaca atctgcaaaa aaagttagaa aaaaagcaga aaatgcacac       60

aatactccat tgctagttct ttatggttct aatatgggaa cagcggaagg aacggccagg      120

gatctagctg acatagctat gtccaaggga tttgccccgc aagtagcaac cctggattcc      180

catgcaggta acttgccaag agaaggtgct gttctaatag ttaccgctag ctacaatggg      240

caccctccag ataatgcgaa gcagttcgtc gattggttag atcaagcatc agcagatgaa      300

gttaagggtg ttagatactc tgtttttgga tgtggagata agaattgggc caccacatat      360

cagaaggttc cggctttcat cgatgaaatg cttgctgcaa aaggggctga aaatatagca      420

gatcgtggtg aggccgacgc aagcgacgat tttgagggta cctatgagga gtggagagag      480

cacatgtggt ctgatgttgc cgcgtatttt aatctagaca tagaaaattc tgaagacaat      540

aaaagtgcct tacttcttca attcgtcgat agtgctgcgg acatgccctt agcaaagatg      600

catggagcct tttcaacgaa cgtagtagcc agtaaggaac ttcaacaacc aggtagtgcc      660

agaagtacac gtcacttgga aattgaatta ccaaaagagg catcctacca agaaggtgac      720

catcttggtg taatcccaag aaactacgaa ggtatagtca atagggtaac ggcaagattt      780

gggctggatg caagccaaca gataagacta gaagcagaag aagaaaaatt ggcgcacctt      840

ccactagcga agacagtatc cgttgaagaa ttattgcaat acgtggaatt gcaggatccc      900

gtcactagaa cgcaattgag agctatggca gcaaagactg tttgtccacc tcacaaggtt      960

gaacttgaag ctctacttga aaaacaagca tacaaagagc aagtgctagc aaagagacta     1020

accatgttag aattgctgga aaaatacccg gcatgcgaaa tggaattctc cgaatttatc     1080

gcgttgttgc caagtattcg tcccaggtat tactcaattt catcttcacc aagggttgac     1140

gagaaacagg catctattac cgtatctgtg gtctctggag aagcttggag tggttacgga     1200

gaatacaagg gtattgcttc caattatctt gcagaactgc aggaagggga tacaattacc     1260

tgctttattt ctactcctca atcagaattt actcttccga aggatccaga aactccgtta     1320

attatggtag gtccgggaac aggagtcgcc cctttcagag gctttgtgca agcaaggaag     1380

caactaaaag aacagggaca aagtctgggt gaggcacatc tatatttcgg ttgcagatct     1440

ccgcatgagg attacttata ccaagaagaa cttgaaaacg cccaatcaga aggtattatc     1500

accttgcata ctgcattcag tagaatgcca aaccagccga aaacttacgt acagcatgtt     1560

atggagcaag atggtaagaa gttaattgag cttttggata agggcgccca cttctacatt     1620

tgcggcgacg gatcccaaat ggcgcctgcc gttgaagcca ccttgatgaa atcatatgca     1680

gatgttcatc aagtttcaga agcggacgcc cgtctttggt tacaacaact agaggagaaa     1740

ggaaggtatg caaaagatgt ttggtaa                                         1767


<210>  118
<211>  588
<212>  PRT
<213>  Bacillus megaterium

<400>  118

Pro Ser Pro Ser Thr Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala 
1               5                   10                  15      


Glu Asn Ala His Asn Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met 
            20                  25                  30          


Gly Thr Ala Glu Gly Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser 
        35                  40                  45              


Lys Gly Phe Ala Pro Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn 
    50                  55                  60                  


Leu Pro Arg Glu Gly Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly 
65                  70                  75                  80  


His Pro Pro Asp Asn Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala 
                85                  90                  95      


Ser Ala Asp Glu Val Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly 
            100                 105                 110         


Asp Lys Asn Trp Ala Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp 
        115                 120                 125             


Glu Met Leu Ala Ala Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu 
    130                 135                 140                 


Ala Asp Ala Ser Asp Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu 
145                 150                 155                 160 


His Met Trp Ser Asp Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn 
                165                 170                 175     


Ser Glu Asp Asn Lys Ser Ala Leu Leu Leu Gln Phe Val Asp Ser Ala 
            180                 185                 190         


Ala Asp Met Pro Leu Ala Lys Met His Gly Ala Phe Ser Thr Asn Val 
        195                 200                 205             


Val Ala Ser Lys Glu Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg 
    210                 215                 220                 


His Leu Glu Ile Glu Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp 
225                 230                 235                 240 


His Leu Gly Val Ile Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val 
                245                 250                 255     


Thr Ala Arg Phe Gly Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala 
            260                 265                 270         


Glu Glu Glu Lys Leu Ala His Leu Pro Leu Ala Lys Thr Val Ser Val 
        275                 280                 285             


Glu Glu Leu Leu Gln Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr 
    290                 295                 300                 


Gln Leu Arg Ala Met Ala Ala Lys Thr Val Cys Pro Pro His Lys Val 
305                 310                 315                 320 


Glu Leu Glu Ala Leu Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu 
                325                 330                 335     


Ala Lys Arg Leu Thr Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys 
            340                 345                 350         


Glu Met Glu Phe Ser Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro 
        355                 360                 365             


Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala 
    370                 375                 380                 


Ser Ile Thr Val Ser Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly 
385                 390                 395                 400 


Glu Tyr Lys Gly Ile Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly 
                405                 410                 415     


Asp Thr Ile Thr Cys Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu 
            420                 425                 430         


Pro Lys Asp Pro Glu Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly 
        435                 440                 445             


Val Ala Pro Phe Arg Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu 
    450                 455                 460                 


Gln Gly Gln Ser Leu Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser 
465                 470                 475                 480 


Pro His Glu Asp Tyr Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser 
                485                 490                 495     


Glu Gly Ile Ile Thr Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln 
            500                 505                 510         


Pro Lys Thr Tyr Val Gln His Val Met Glu Gln Asp Gly Lys Lys Leu 
        515                 520                 525             


Ile Glu Leu Leu Asp Lys Gly Ala His Phe Tyr Ile Cys Gly Asp Gly 
    530                 535                 540                 


Ser Gln Met Ala Pro Ala Val Glu Ala Thr Leu Met Lys Ser Tyr Ala 
545                 550                 555                 560 


Asp Val His Gln Val Ser Glu Ala Asp Ala Arg Leu Trp Leu Gln Gln 
                565                 570                 575     


Leu Glu Glu Lys Gly Arg Tyr Ala Lys Asp Val Trp 
            580                 585             


<210>  119
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized BMR W1046A

<400>  119
ccaagtccta gtaccgaaca atctgcaaaa aaagttagaa aaaaagcaga aaatgcacac       60

aatactccat tgctagttct ttatggttct aatatgggaa cagcggaagg aacggccagg      120

gatctagctg acatagctat gtccaaggga tttgccccgc aagtagcaac cctggattcc      180

catgcaggta acttgccaag agaaggtgct gttctaatag ttaccgctag ctacaatggg      240

caccctccag ataatgcgaa gcagttcgtc gattggttag atcaagcatc agcagatgaa      300

gttaagggtg ttagatactc tgtttttgga tgtggagata agaattgggc caccacatat      360

cagaaggttc cggctttcat cgatgaaatg cttgctgcaa aaggggctga aaatatagca      420

gatcgtggtg aggccgacgc aagcgacgat tttgagggta cctatgagga gtggagagag      480

cacatgtggt ctgatgttgc cgcgtatttt aatctagaca tagaaaattc tgaagacaat      540

aaaagtgcct tacttcttca attcgtcgat agtgctgcgg acatgccctt agcaaagatg      600

catggagcct tttcaacgaa cgtagtagcc agtaaggaac ttcaacaacc aggtagtgcc      660

agaagtacac gtcacttgga aattgaatta ccaaaagagg catcctacca agaaggtgac      720

catcttggtg taatcccaag aaactacgaa ggtatagtca atagggtaac ggcaagattt      780

gggctggatg caagccaaca gataagacta gaagcagaag aagaaaaatt ggcgcacctt      840

ccactagcga agacagtatc cgttgaagaa ttattgcaat acgtggaatt gcaggatccc      900

gtcactagaa cgcaattgag agctatggca gcaaagactg tttgtccacc tcacaaggtt      960

gaacttgaag ctctacttga aaaacaagca tacaaagagc aagtgctagc aaagagacta     1020

accatgttag aattgctgga aaaatacccg gcatgcgaaa tggaattctc cgaatttatc     1080

gcgttgttgc caagtattcg tcccaggtat tactcaattt catcttcacc aagggttgac     1140

gagaaacagg catctattac cgtatctgtg gtctctggag aagcttggag tggttacgga     1200

gaatacaagg gtattgcttc caattatctt gcagaactgc aggaagggga tacaattacc     1260

tgctttattt ctactcctca atcagaattt actcttccga aggatccaga aactccgtta     1320

attatggtag gtccgggaac aggagtcgcc cctttcagag gctttgtgca agcaaggaag     1380

caactaaaag aacagggaca aagtctgggt gaggcacatc tatatttcgg ttgcagatct     1440

ccgcatgagg attacttata ccaagaagaa cttgaaaacg cccaatcaga aggtattatc     1500

accttgcata ctgcattcag tagaatgcca aaccagccga aaacttacgt acagcatgtt     1560

atggagcaag atggtaagaa gttaattgag cttttggata agggcgccca cttctacatt     1620

tgcggcgacg gatcccaaat ggcgcctgcc gttgaagcca ccttgatgaa atcatatgca     1680

gatgttcatc aagtttcaga agcggacgcc cgtctttggt tacaacaact agaggagaaa     1740

ggaaggtatg caaaagatgt tgcttaa                                         1767


<210>  120
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMR W1046A

<400>  120

Pro Ser Pro Ser Thr Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala 
1               5                   10                  15      


Glu Asn Ala His Asn Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met 
            20                  25                  30          


Gly Thr Ala Glu Gly Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser 
        35                  40                  45              


Lys Gly Phe Ala Pro Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn 
    50                  55                  60                  


Leu Pro Arg Glu Gly Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly 
65                  70                  75                  80  


His Pro Pro Asp Asn Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala 
                85                  90                  95      


Ser Ala Asp Glu Val Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly 
            100                 105                 110         


Asp Lys Asn Trp Ala Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp 
        115                 120                 125             


Glu Met Leu Ala Ala Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu 
    130                 135                 140                 


Ala Asp Ala Ser Asp Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu 
145                 150                 155                 160 


His Met Trp Ser Asp Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn 
                165                 170                 175     


Ser Glu Asp Asn Lys Ser Ala Leu Leu Leu Gln Phe Val Asp Ser Ala 
            180                 185                 190         


Ala Asp Met Pro Leu Ala Lys Met His Gly Ala Phe Ser Thr Asn Val 
        195                 200                 205             


Val Ala Ser Lys Glu Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg 
    210                 215                 220                 


His Leu Glu Ile Glu Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp 
225                 230                 235                 240 


His Leu Gly Val Ile Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val 
                245                 250                 255     


Thr Ala Arg Phe Gly Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala 
            260                 265                 270         


Glu Glu Glu Lys Leu Ala His Leu Pro Leu Ala Lys Thr Val Ser Val 
        275                 280                 285             


Glu Glu Leu Leu Gln Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr 
    290                 295                 300                 


Gln Leu Arg Ala Met Ala Ala Lys Thr Val Cys Pro Pro His Lys Val 
305                 310                 315                 320 


Glu Leu Glu Ala Leu Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu 
                325                 330                 335     


Ala Lys Arg Leu Thr Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys 
            340                 345                 350         


Glu Met Glu Phe Ser Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro 
        355                 360                 365             


Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala 
    370                 375                 380                 


Ser Ile Thr Val Ser Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly 
385                 390                 395                 400 


Glu Tyr Lys Gly Ile Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly 
                405                 410                 415     


Asp Thr Ile Thr Cys Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu 
            420                 425                 430         


Pro Lys Asp Pro Glu Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly 
        435                 440                 445             


Val Ala Pro Phe Arg Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu 
    450                 455                 460                 


Gln Gly Gln Ser Leu Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser 
465                 470                 475                 480 


Pro His Glu Asp Tyr Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser 
                485                 490                 495     


Glu Gly Ile Ile Thr Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln 
            500                 505                 510         


Pro Lys Thr Tyr Val Gln His Val Met Glu Gln Asp Gly Lys Lys Leu 
        515                 520                 525             


Ile Glu Leu Leu Asp Lys Gly Ala His Phe Tyr Ile Cys Gly Asp Gly 
    530                 535                 540                 


Ser Gln Met Ala Pro Ala Val Glu Ala Thr Leu Met Lys Ser Tyr Ala 
545                 550                 555                 560 


Asp Val His Gln Val Ser Glu Ala Asp Ala Arg Leu Trp Leu Gln Gln 
                565                 570                 575     


Leu Glu Glu Lys Gly Arg Tyr Ala Lys Asp Val Ala 
            580                 585             


<210>  121
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  121
ccatcaaga                                                                9


<210>  122
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  122

Pro Ser Arg 
1           


