                         SEQUENCE LISTING

<110>  Neurimmune Holding AG
 
<120>  Human-derived anti-dipeptide repeats (DPRs) antibody

<130>  NE30A52/P-WO

<150>  EP14187180.6
<151>  2014-09-30

<150>  EP15180310.3
<151>  2015-08-07

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-308.18F7-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  1
tgc cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg         48
Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser           
1               5                   10                  15                

gag acc ctg tcc gtc acg tgc act gtc tct ggt ggc tcc atc aat gat         96
Glu Thr Leu Ser Val Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asp           
            20                  25                  30                    

tac tac tgg aac tgg atc cgg cag ccc gcc ggg aag gga ctg gag tgg        144
Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att ggg cgt ata tat gcc agt ggg acc atc aat tac aac cct tcc ctc        192
Ile Gly Arg Ile Tyr Ala Ser Gly Thr Ile Asn Tyr Asn Pro Ser Leu           
    50                  55                  60                            

cag agt cga gtc acc atg tca att gac acg tcc aag aac cag ttc tcc        240
Gln Ser Arg Val Thr Met Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser           
65                  70                  75                  80            

cta gac ctc atc tct gtg tcc gcc gcg gac acg gcc gtc tac tat tgt        288
Leu Asp Leu Ile Ser Val Ser Ala Ala Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga tgg ggc cag gtg gtc ggg gac tac tac tac ggg atg gac gtc        336
Ala Arg Trp Gly Gln Val Val Gly Asp Tyr Tyr Tyr Gly Met Asp Val           
            100                 105                 110                   

tgg ggc cag ggg acc acg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                               
        115                 120                                           


<210>  2
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Glu Thr Leu Ser Val Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Arg Ile Tyr Ala Ser Gly Thr Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Gln Ser Arg Val Thr Met Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asp Leu Ile Ser Val Ser Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Gln Val Val Gly Asp Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  3
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-308.18F7 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(300)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  3
tgc gaa att gtg ctg act cag tct cca ctc tcc ctg tcc gtc acc cct         48
Cys Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro           
1               5                   10                  15                

gga gag ccg gcc tcc atc tcc tgc aag tct agt cag agc ctc caa cat         96
Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Gln His           
            20                  25                  30                    

aca aat gga tac aat tac ttg gat tgg tac ctg ctg aag cca ggg cag        144
Thr Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Leu Lys Pro Gly Gln           
        35                  40                  45                        

tct cca caa ctc cta atc ttc ttg act tct aat cgg gcc tcc ggg gtc        192
Ser Pro Gln Leu Leu Ile Phe Leu Thr Ser Asn Arg Ala Ser Gly Val           
    50                  55                  60                            

cct gac agg ttc agt ggc agt gga tca ggc aca aat ttt aca ctg aaa        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys           
65                  70                  75                  80            

atc agc aga gtg gag gct gag gat gtt ggg gtc tat tat tgc atg gaa        288
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Glu           
                85                  90                  95                

ggt ata caa ttg tgg acg ttc ggc caa ggg acc aag ctg gag atc aaa        336
Gly Ile Gln Leu Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   


<210>  4
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Gln His 
            20                  25                  30          


Thr Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Leu Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Phe Leu Thr Ser Asn Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Glu 
                85                  90                  95      


Gly Ile Gln Leu Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-308.18F7 VK-PIMC variable light-kappa chain (VK) sequence 
       after correction of primer induced mutations

<220>
<221>  V_region
<222>  (73)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(300)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  5
tgc gac atc gtg atg acc cag tct cca ctc tcc ctg tcc gtc acc cct         48
Cys Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro           
1               5                   10                  15                

gga gag ccg gcc tcc atc tcc tgc aag tct agt cag agc ctc caa cat         96
Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Gln His           
            20                  25                  30                    

aca aat gga tac aat tac ttg gat tgg tac ctg ctg aag cca ggg cag        144
Thr Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Leu Lys Pro Gly Gln           
        35                  40                  45                        

tct cca caa ctc cta atc ttc ttg act tct aat cgg gcc tcc ggg gtc        192
Ser Pro Gln Leu Leu Ile Phe Leu Thr Ser Asn Arg Ala Ser Gly Val           
    50                  55                  60                            

cct gac agg ttc agt ggc agt gga tca ggc aca aat ttt aca ctg aaa        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys           
65                  70                  75                  80            

atc agc aga gtg gag gct gag gat gtt ggg gtc tat tat tgc atg gaa        288
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Glu           
                85                  90                  95                

ggt ata caa ttg tgg acg ttc ggc caa ggg acc aag gtg gag atc aaa        336
Gly Ile Gln Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  6
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Gln His 
            20                  25                  30          


Thr Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Leu Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Phe Leu Thr Ser Asn Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Glu 
                85                  90                  95      


Gly Ile Gln Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-308.15O7 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  7
tgc cag gtg cag ctg gtg gag tct ggg gga ggc gta gtc cag cct ggg         48
Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly           
1               5                   10                  15                

agg tcc ctg aga ctg tcc tgt gca gcc tct gga ttc acc ttc agt aat         96
Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn           
            20                  25                  30                    

cat gct atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg        144
His Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

gtg gca gtt ata tca tat gat ggc gag aac aca tat tat gca gac tcc        192
Val Ala Val Ile Ser Tyr Asp Gly Glu Asn Thr Tyr Tyr Ala Asp Ser           
    50                  55                  60                            

att gag ggc cga ttc acc att tcc aga gac aat ttc aag aac aca ctc        240
Ile Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu           
65                  70                  75                  80            

ttt cta caa atg tac agc ctg aca gct gat gac acg gct atg tac ttc        288
Phe Leu Gln Met Tyr Ser Leu Thr Ala Asp Asp Thr Ala Met Tyr Phe           
                85                  90                  95                

tgt gcg aga ggg ggc cgt cgg ggg cac ttc acc tca tac tac ctt gac        336
Cys Ala Arg Gly Gly Arg Arg Gly His Phe Thr Ser Tyr Tyr Leu Asp           
            100                 105                 110                   

tac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  8
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  8

Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 
            20                  25                  30          


His Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Ser Tyr Asp Gly Glu Asn Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Ile Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Tyr Ser Leu Thr Ala Asp Asp Thr Ala Met Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Gly Arg Arg Gly His Phe Thr Ser Tyr Tyr Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  9
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-308.15O7 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  9
tgc gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta         48
Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val           
1               5                   10                  15                

gga gac aga gtc acc atc act tgc cgg gca agc cag aac ata gac aag         96
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys           
            20                  25                  30                    

tac tta aat tgg tat cag cag ata ccg ggg aaa gcc cct aag ctc ctg        144
Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tat gct gca tcg agt ttg cac agt ggg gtc cca tca agg ttc agt        192
Ile Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser           
    50                  55                  60                            

ggc agt gga tct ggg aca gat ttc tct ctc acc atc agc agt ctg caa        240
Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

cct gaa gat ttt gca att tac tac tgt caa cag agt tac agt tcc ttc        288
Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Phe           
                85                  90                  95                

cgg acg ttc ggc caa ggg acc aag ctg gag atc aaa                        324
Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                           
            100                 105                                       


<210>  10
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Phe 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  11
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-308.15O7 VK-PIMC variable light-kappa chain (VK) sequence 
       after correction of primer induced mutations

<220>
<221>  V_region
<222>  (73)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  11
tgc gac atc cag atg acc cag tct ccg tcc tcc ctg tct gca tct gta         48
Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val           
1               5                   10                  15                

gga gac aga gtc acc atc act tgc cgg gca agc cag aac ata gac aag         96
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys           
            20                  25                  30                    

tac tta aat tgg tat cag cag ata ccg ggg aaa gcc cct aag ctc ctg        144
Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tat gct gca tcg agt ttg cac agt ggg gtc cca tca agg ttc agt        192
Ile Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser           
    50                  55                  60                            

ggc agt gga tct ggg aca gat ttc tct ctc acc atc agc agt ctg caa        240
Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

cct gaa gat ttt gca att tac tac tgt caa cag agt tac agt tcc ttc        288
Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Phe           
                85                  90                  95                

cgg acg ttc ggc caa ggg acc aag gtg gag atc aaa                        324
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                           
            100                 105                                       


<210>  12
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Phe 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  13
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-308.5G2-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (298)..(339)
<223>  complementarity determining region (CDR) VH-CDR1

<400>  13
tgc gag gtg cag ctg gtg cag tct ggg gct gac ttg cgg aac cct ggg         48
Cys Glu Val Gln Leu Val Gln Ser Gly Ala Asp Leu Arg Asn Pro Gly           
1               5                   10                  15                

gcc tca gtg acg gtt tcc tgc acg gct tct gga tac cat ttc gct gac         96
Ala Ser Val Thr Val Ser Cys Thr Ala Ser Gly Tyr His Phe Ala Asp           
            20                  25                  30                    

aat gct ata aac tgg ctg cgc cag gcc ccc gga caa agg ctt gag tgg        144
Asn Ala Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp           
        35                  40                  45                        

atg ggg tgg atc aac att tac agt ggt aac aca aaa tat tca cag aac        192
Met Gly Trp Ile Asn Ile Tyr Ser Gly Asn Thr Lys Tyr Ser Gln Asn           
    50                  55                  60                            

ttc cag ggc aga gtc acc ttt acc aga aac aca tcc gcg agc aca gcc        240
Phe Gln Gly Arg Val Thr Phe Thr Arg Asn Thr Ser Ala Ser Thr Ala           
65                  70                  75                  80            

ttc atg cac ctg cgc agc ctg aga tca gaa gac acg gct gtg tat ttc        288
Phe Met His Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe           
                85                  90                  95                

tgt gcg aga gac cct gat agc agt gga tat tac ttg ccc tat ttt gac        336
Cys Ala Arg Asp Pro Asp Ser Ser Gly Tyr Tyr Leu Pro Tyr Phe Asp           
            100                 105                 110                   

tac tgg ggc caa gga acc ctg gtc acc gtc tcc tcg                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  14
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Glu Val Gln Leu Val Gln Ser Gly Ala Asp Leu Arg Asn Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Val Ser Cys Thr Ala Ser Gly Tyr His Phe Ala Asp 
            20                  25                  30          


Asn Ala Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Met Gly Trp Ile Asn Ile Tyr Ser Gly Asn Thr Lys Tyr Ser Gln Asn 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Phe Thr Arg Asn Thr Ser Ala Ser Thr Ala 
65                  70                  75                  80  


Phe Met His Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Pro Asp Ser Ser Gly Tyr Tyr Leu Pro Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  15
<211>  342
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(342)
<223>  NI-308.5G2 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(123)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (169)..(189)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (286)..(312)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  15
tgc gac atc cag ttg acc cag tct cca gac tcc ctg act ttg tct ctg         48
Cys Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Thr Leu Ser Leu           
1               5                   10                  15                

ggc gag agg gcc acc atc aac tgc aag tcc agc cag agt gtt ttc tac         96
Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr           
            20                  25                  30                    

aac tcc aac aat aag aac tac tta gct tgg tat cag cag aaa cca gga        144
Asn Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly           
        35                  40                  45                        

cag cct cct aag ttg ctc atg tac tgg gca tct acc cgg gag tcc ggg        192
Gln Pro Pro Lys Leu Leu Met Tyr Trp Ala Ser Thr Arg Glu Ser Gly           
    50                  55                  60                            

gtc act gac cga ttc agt ggc agc ggg tct ggg aca gat ttt act ctc        240
Val Thr Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu           
65                  70                  75                  80            

acc att acc aac ctg cag gct gaa gat gtg gca gtc tat tat tgt cag        288
Thr Ile Thr Asn Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln           
                85                  90                  95                

caa ttt tat agt tct cct ctc act ttc ggc gga ggg acc aag gtg gag        336
Gln Phe Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu           
            100                 105                 110                   

atc aaa                                                                342
Ile Lys                                                                   
                                                                          


<210>  16
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Thr Leu Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr 
            20                  25                  30          


Asn Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Met Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
    50                  55                  60                  


Val Thr Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Thr Asn Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Phe Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210>  17
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-308.5G2 VH-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  17
tgc cag gtg cag ctg gtg caa tct ggg gct gac ttg cgg aac cct ggg         48
Cys Gln Val Gln Leu Val Gln Ser Gly Ala Asp Leu Arg Asn Pro Gly           
1               5                   10                  15                

gcc tca gtg acg gtt tcc tgc acg gct tct gga tac cat ttc gct gac         96
Ala Ser Val Thr Val Ser Cys Thr Ala Ser Gly Tyr His Phe Ala Asp           
            20                  25                  30                    

aat gct ata aac tgg ctg cgc cag gcc ccc gga caa agg ctt gag tgg        144
Asn Ala Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp           
        35                  40                  45                        

atg ggg tgg atc aac att tac agt ggt aac aca aaa tat tca cag aac        192
Met Gly Trp Ile Asn Ile Tyr Ser Gly Asn Thr Lys Tyr Ser Gln Asn           
    50                  55                  60                            

ttc cag ggc aga gtc acc ttt acc aga aac aca tcc gcg agc aca gcc        240
Phe Gln Gly Arg Val Thr Phe Thr Arg Asn Thr Ser Ala Ser Thr Ala           
65                  70                  75                  80            

ttc atg cac ctg cgc agc ctg aga tca gaa gac acg gct gtg tat ttc        288
Phe Met His Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe           
                85                  90                  95                

tgt gcg aga gac cct gat agc agt gga tat tac ttg ccc tat ttt gac        336
Cys Ala Arg Asp Pro Asp Ser Ser Gly Tyr Tyr Leu Pro Tyr Phe Asp           
            100                 105                 110                   

tac tgg ggc caa gga acc ctg gtc acc gtc tcc tcg                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  18
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Gln Val Gln Leu Val Gln Ser Gly Ala Asp Leu Arg Asn Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Val Ser Cys Thr Ala Ser Gly Tyr His Phe Ala Asp 
            20                  25                  30          


Asn Ala Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Met Gly Trp Ile Asn Ile Tyr Ser Gly Asn Thr Lys Tyr Ser Gln Asn 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Phe Thr Arg Asn Thr Ser Ala Ser Thr Ala 
65                  70                  75                  80  


Phe Met His Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Pro Asp Ser Ser Gly Tyr Tyr Leu Pro Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  19
<211>  342
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(342)
<223>  NI-308.5G2 VK-PIMC variable light-kappa chain (VK) sequence after
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (73)..(123)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (169)..(189)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (286)..(312)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  19
tgc gac atc gtg atg acc cag tct cca gac tcc ctg act ttg tct ctg         48
Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Thr Leu Ser Leu           
1               5                   10                  15                

ggc gag agg gcc acc atc aac tgc aag tcc agc cag agt gtt ttc tac         96
Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr           
            20                  25                  30                    

aac tcc aac aat aag aac tac tta gct tgg tat cag cag aaa cca gga        144
Asn Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly           
        35                  40                  45                        

cag cct cct aag ttg ctc atg tac tgg gca tct acc cgg gag tcc ggg        192
Gln Pro Pro Lys Leu Leu Met Tyr Trp Ala Ser Thr Arg Glu Ser Gly           
    50                  55                  60                            

gtc act gac cga ttc agt ggc agc ggg tct ggg aca gat ttt act ctc        240
Val Thr Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu           
65                  70                  75                  80            

acc att acc aac ctg cag gct gaa gat gtg gca gtc tat tat tgt cag        288
Thr Ile Thr Asn Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln           
                85                  90                  95                

caa ttt tat agt tct cct ctc act ttc ggc gga ggg acc aag gtg gag        336
Gln Phe Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu           
            100                 105                 110                   

atc aaa                                                                342
Ile Lys                                                                   
                                                                          


<210>  20
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Thr Leu Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr 
            20                  25                  30          


Asn Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Met Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
    50                  55                  60                  


Val Thr Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Thr Asn Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Phe Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210>  21
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-308.28G1-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  21
tgc cag gtg cag ctg cag gag tcg ggc cca aga ctg gtg aag ccc tcg         48
Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser           
1               5                   10                  15                

gag acc ctg tcg ctc acg tgc act gtc gct ggc ggc tcc gtc aat agt         96
Glu Thr Leu Ser Leu Thr Cys Thr Val Ala Gly Gly Ser Val Asn Ser           
            20                  25                  30                    

tac tat tgg acc tgg atc cag cag tcc ccc ggg aag gga ctg gag tgg        144
Tyr Tyr Trp Thr Trp Ile Gln Gln Ser Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

ctt ggg cgt atc tat atc gct ggg agg acc aac tat aac ccc tcc ctc        192
Leu Gly Arg Ile Tyr Ile Ala Gly Arg Thr Asn Tyr Asn Pro Ser Leu           
    50                  55                  60                            

acg agt cga atc gcc ctg tca gtg gac acg tcc agg aac cag ttg tcc        240
Thr Ser Arg Ile Ala Leu Ser Val Asp Thr Ser Arg Asn Gln Leu Ser           
65                  70                  75                  80            

ctg aag ctg acg tct gtg acc gcc gcg gac acg gcc ata tat tat tgt        288
Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aga tgg gga gcg gag agt ggt gac tac tac tat gga gtg gac gtc        336
Ala Arg Trp Gly Ala Glu Ser Gly Asp Tyr Tyr Tyr Gly Val Asp Val           
            100                 105                 110                   

tgg ggc cca ggc acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  22
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  22

Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser 
1               5                   10                  15      


Glu Thr Leu Ser Leu Thr Cys Thr Val Ala Gly Gly Ser Val Asn Ser 
            20                  25                  30          


Tyr Tyr Trp Thr Trp Ile Gln Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Leu Gly Arg Ile Tyr Ile Ala Gly Arg Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Thr Ser Arg Ile Ala Leu Ser Val Asp Thr Ser Arg Asn Gln Leu Ser 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Ala Glu Ser Gly Asp Tyr Tyr Tyr Gly Val Asp Val 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  23
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-308.28G1 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  23
tgc gaa att gtg atg acg cag tct cca ctc tcc ctg ccc gtc acc cct         48
Cys Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro           
1               5                   10                  15                

gga gag ccg gcc tcc atc tcc tgc aag tct agt gag gga ctc ctg cat         96
Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Glu Gly Leu Leu His           
            20                  25                  30                    

agt aat ggt tac acc tat ttg gat tgg tac ctg cag aag cca ggg cag        144
Ser Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln           
        35                  40                  45                        

gct ccg cag ctc ctg atc ttt ctg gct tct aat cgg gcc gcc ggg gtc        192
Ala Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ala Gly Val           
    50                  55                  60                            

cct gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aag        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys           
65                  70                  75                  80            

atc agc aga gtg gag gct gag gat gtt ggc gtt tat tac tgc atg cag        288
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln           
                85                  90                  95                

gct ata caa agt cct tgg acg ttc ggc cca ggg acc aag gtg gaa atc        336
Ala Ile Gln Ser Pro Trp Thr Phe Gly Pro Gly Thr Lys Val Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  24
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  24

Cys Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Glu Gly Leu Leu His 
            20                  25                  30          


Ser Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ala Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Ile Gln Ser Pro Trp Thr Phe Gly Pro Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  25
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-308.28G1 VH-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  25
tgc cag gtg cag ctg cag gag tcg ggc cca aga ctg gtg aag ccc tcg         48
Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser           
1               5                   10                  15                

gag acc ctg tcg ctc acg tgc act gtc gct ggc ggc tcc gtc aat agt         96
Glu Thr Leu Ser Leu Thr Cys Thr Val Ala Gly Gly Ser Val Asn Ser           
            20                  25                  30                    

tac tat tgg acc tgg atc cag cag tcc ccc ggg aag gga ctg gag tgg        144
Tyr Tyr Trp Thr Trp Ile Gln Gln Ser Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

ctt ggg cgt atc tat atc gct ggg agg acc aac tat aac ccc tcc ctc        192
Leu Gly Arg Ile Tyr Ile Ala Gly Arg Thr Asn Tyr Asn Pro Ser Leu           
    50                  55                  60                            

acg agt cga atc gcc ctg tca gtg gac acg tcc agg aac cag ttg tcc        240
Thr Ser Arg Ile Ala Leu Ser Val Asp Thr Ser Arg Asn Gln Leu Ser           
65                  70                  75                  80            

ctg aag ctg acg tct gtg acc gcc gcg gac acg gcc ata tat tat tgt        288
Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aga tgg gga gcg gag agt ggt gac tac tac tat gga gtg gac gtc        336
Ala Arg Trp Gly Ala Glu Ser Gly Asp Tyr Tyr Tyr Gly Val Asp Val           
            100                 105                 110                   

tgg ggc cca ggg acc acg gtc acc gtc tcc tca                            369
Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser                               
        115                 120                                           


<210>  26
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  26

Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser 
1               5                   10                  15      


Glu Thr Leu Ser Leu Thr Cys Thr Val Ala Gly Gly Ser Val Asn Ser 
            20                  25                  30          


Tyr Tyr Trp Thr Trp Ile Gln Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Leu Gly Arg Ile Tyr Ile Ala Gly Arg Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Thr Ser Arg Ile Ala Leu Ser Val Asp Thr Ser Arg Asn Gln Leu Ser 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Ala Glu Ser Gly Asp Tyr Tyr Tyr Gly Val Asp Val 
            100                 105                 110         


Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  27
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-308.28G1 VK-PIMC variable light-kappa chain (VK) sequence 
       after correction of primer induced mutations

<220>
<221>  V-region
<222>  (73)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V-region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V-region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  27
tgc gat att gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct         48
Cys Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro           
1               5                   10                  15                

gga gag ccg gcc tcc atc tcc tgc aag tct agt gag gga ctc ctg cat         96
Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Glu Gly Leu Leu His           
            20                  25                  30                    

agt aat ggt tac acc tat ttg gat tgg tac ctg cag aag cca ggg cag        144
Ser Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln           
        35                  40                  45                        

gct ccg cag ctc ctg atc ttt ctg gct tct aat cgg gcc gcc ggg gtc        192
Ala Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ala Gly Val           
    50                  55                  60                            

cct gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aag        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys           
65                  70                  75                  80            

atc agc aga gtg gag gct gag gat gtt ggc gtt tat tac tgc atg cag        288
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln           
                85                  90                  95                

gct ata caa agt cct tgg acg ttc ggc cca ggg acc aag gtg gaa atc        336
Ala Ile Gln Ser Pro Trp Thr Phe Gly Pro Gly Thr Lys Val Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  28
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  28

Cys Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Glu Gly Leu Leu His 
            20                  25                  30          


Ser Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ala Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Ile Gln Ser Pro Trp Thr Phe Gly Pro Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  29
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(387)
<223>  NI-308.45C2-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (79)..(114)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(114)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (157)..(210)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (307)..(354)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  29
tgc cag ctg cag ctg cag gag tcg ggt cca gga ctg gtg aag ccc tcg         48
Cys Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser           
1               5                   10                  15                

cag atc ctc tca ctc acc tgt gcc atc tcc ggg gac agt gtc ttc agc         96
Gln Ile Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Phe Ser           
            20                  25                  30                    

aac agt gct gct tgg aac tgg atc agg cag tcc cca tcg aga ggc ctt        144
Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu           
        35                  40                  45                        

gag tgg ctg gga agg aca tac tac agg tcc aag tgg gat aat gat tat        192
Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Asp Asn Asp Tyr           
    50                  55                  60                            

gca cca tct gtg aaa agt cga ata agt atc aac cca gac aca tcc aag        240
Ala Pro Ser Val Lys Ser Arg Ile Ser Ile Asn Pro Asp Thr Ser Lys           
65                  70                  75                  80            

aac cag ttc tcc ctg cag ttg aat tct gtg act ccc gag gac acg gct        288
Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala           
                85                  90                  95                

gtg tat tat tgt gca aga gag gtc gca tat tgt ggt ggt gac tgc tat        336
Val Tyr Tyr Cys Ala Arg Glu Val Ala Tyr Cys Gly Gly Asp Cys Tyr           
            100                 105                 110                   

tct gtt tcc ttt gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc        384
Ser Val Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser           
        115                 120                 125                       

tcg                                                                    387
Ser                                                                       
                                                                          


<210>  30
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  30

Cys Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Ile Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Phe Ser 
            20                  25                  30          


Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu 
        35                  40                  45              


Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Asp Asn Asp Tyr 
    50                  55                  60                  


Ala Pro Ser Val Lys Ser Arg Ile Ser Ile Asn Pro Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Glu Val Ala Tyr Cys Gly Gly Asp Cys Tyr 
            100                 105                 110         


Ser Val Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  31
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-308.45C2 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  31
tgc gaa att gtg atg aca cag tct cca ctc tcc ctg ccc gtc acc cct         48
Cys Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro           
1               5                   10                  15                

gga gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctc cag         96
Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Gln           
            20                  25                  30                    

agt aat gga tac acc tat ttg gat tgg tac ctg cag aag cca ggg cag        144
Ser Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln           
        35                  40                  45                        

tct cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc        192
Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val           
    50                  55                  60                            

cct gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys           
65                  70                  75                  80            

atc agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa        288
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln           
                85                  90                  95                

gct cta caa act ccg ctc act ttc ggc gga ggg acc aag gtg gag atc        336
Ala Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  32
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Gln 
            20                  25                  30          


Ser Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  33
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(387)
<223>  NI-308.45C2 VH-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (79)..(114)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(114)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (157)..(210)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (307)..(354)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  33
tgc cag ctg cag ctg cag cag tca ggt cca gga ctg gtg aag ccc tcg         48
Cys Gln Leu Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser           
1               5                   10                  15                

cag atc ctc tca ctc acc tgt gcc atc tcc ggg gac agt gtc ttc agc         96
Gln Ile Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Phe Ser           
            20                  25                  30                    

aac agt gct gct tgg aac tgg atc agg cag tcc cca tcg aga ggc ctt        144
Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu           
        35                  40                  45                        

gag tgg ctg gga agg aca tac tac agg tcc aag tgg gat aat gat tat        192
Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Asp Asn Asp Tyr           
    50                  55                  60                            

gca cca tct gtg aaa agt cga ata agt atc aac cca gac aca tcc aag        240
Ala Pro Ser Val Lys Ser Arg Ile Ser Ile Asn Pro Asp Thr Ser Lys           
65                  70                  75                  80            

aac cag ttc tcc ctg cag ttg aat tct gtg act ccc gag gac acg gct        288
Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala           
                85                  90                  95                

gtg tat tat tgt gca aga gag gtc gca tat tgt ggt ggt gac tgc tat        336
Val Tyr Tyr Cys Ala Arg Glu Val Ala Tyr Cys Gly Gly Asp Cys Tyr           
            100                 105                 110                   

tct gtt tcc ttt gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc        384
Ser Val Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser           
        115                 120                 125                       

tcg                                                                    387
Ser                                                                       
                                                                          


<210>  34
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  34

Cys Gln Leu Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Ile Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Phe Ser 
            20                  25                  30          


Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu 
        35                  40                  45              


Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Asp Asn Asp Tyr 
    50                  55                  60                  


Ala Pro Ser Val Lys Ser Arg Ile Ser Ile Asn Pro Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Glu Val Ala Tyr Cys Gly Gly Asp Cys Tyr 
            100                 105                 110         


Ser Val Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  35
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-308.45C2 VK-PIMC variable light-kappa chain (VK) sequence 
       after correction of primer induced mutations

<220>
<221>  V_region
<222>  (73)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  35
tgc gat att gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct         48
Cys Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro           
1               5                   10                  15                

gga gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctc cag         96
Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Gln           
            20                  25                  30                    

agt aat gga tac acc tat ttg gat tgg tac ctg cag aag cca ggg cag        144
Ser Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln           
        35                  40                  45                        

tct cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc        192
Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val           
    50                  55                  60                            

cct gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys           
65                  70                  75                  80            

atc agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa        288
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln           
                85                  90                  95                

gct cta caa act ccg ctc act ttc ggc gga ggg acc aag gtg gag atc        336
Ala Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  36
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  36

Cys Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Gln 
            20                  25                  30          


Ser Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  37
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  NI-308.24E11-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (151)..(189)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(348)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  37
tgc cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg         48
Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser           
1               5                   10                  15                

gag acc ctg tcc ctc acc tgc act gtc tct act act tcc ctc aga agt         96
Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Thr Thr Ser Leu Arg Ser           
            20                  25                  30                    

tat ttc tgg agt tgg atc cgg cag ccc cca ggg aag ggg ctg gag tgg        144
Tyr Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att ggg tat gtc tat tac agt ggg agt acc atc tac aat ccg tcc ctc        192
Ile Gly Tyr Val Tyr Tyr Ser Gly Ser Thr Ile Tyr Asn Pro Ser Leu           
    50                  55                  60                            

aag aat cga gtc acc ata tcc ata gac acg tcc aag aac cag ttc tcc        240
Lys Asn Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser           
65                  70                  75                  80            

ctg aac ctg cgc tct gtg acc gct gcg gat acg gcc atg tat ttc tgt        288
Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Phe Cys           
                85                  90                  95                

gcg aga ggc gtc ccg gct gag act gat gcg cgg gac ttc ccg ccc tac        336
Ala Arg Gly Val Pro Ala Glu Thr Asp Ala Arg Asp Phe Pro Pro Tyr           
            100                 105                 110                   

tac ttt gat cac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg            381
Tyr Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  38
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  38

Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Thr Thr Ser Leu Arg Ser 
            20                  25                  30          


Tyr Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Val Tyr Tyr Ser Gly Ser Thr Ile Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Val Pro Ala Glu Thr Asp Ala Arg Asp Phe Pro Pro Tyr 
            100                 105                 110         


Tyr Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  39
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-308.24E11 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  39
tgc gac atc cag ttg acc cag tct cca tcc tcc ctg tct gcg tca gta         48
Cys Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val           
1               5                   10                  15                

gga aac aga atc acc ttc act tgc cag gcg agt cag gac att aga tat         96
Gly Asn Arg Ile Thr Phe Thr Cys Gln Ala Ser Gln Asp Ile Arg Tyr           
            20                  25                  30                    

tat tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aaa ctc ctg        144
Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tac gat gtg tcc aat ttg gat aca ggg gtg cca cca agg ttc agt        192
Ile Tyr Asp Val Ser Asn Leu Asp Thr Gly Val Pro Pro Arg Phe Ser           
    50                  55                  60                            

gga agt gga tct ggg aca aat ttc act ttc acc atc agc agc ctg cag        240
Gly Ser Gly Ser Gly Thr Asn Phe Thr Phe Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

cct gaa gat att gca gtt tat tac tgt caa cag tat gaa gga ctc cct        288
Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln Tyr Glu Gly Leu Pro           
                85                  90                  95                

gtg acc ttc ggc ggg ggg acc aag gtg gag atc aaa                        324
Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                           
            100                 105                                       


<210>  40
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  40

Cys Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asn Arg Ile Thr Phe Thr Cys Gln Ala Ser Gln Asp Ile Arg Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Val Ser Asn Leu Asp Thr Gly Val Pro Pro Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asn Phe Thr Phe Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln Tyr Glu Gly Leu Pro 
                85                  90                  95      


Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  41
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-308.24E11 VK-PIMC variable light-kappa chain (VK) sequence 
       after correction of primer induced mutations

<220>
<221>  V_region
<222>  (73)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  41
tgc gac atc cag atg acc cag tct cca tcc tcc ctg tct gcg tca gta         48
Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val           
1               5                   10                  15                

gga aac aga atc acc ttc act tgc cag gcg agt cag gac att aga tat         96
Gly Asn Arg Ile Thr Phe Thr Cys Gln Ala Ser Gln Asp Ile Arg Tyr           
            20                  25                  30                    

tat tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aaa ctc ctg        144
Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tac gat gtg tcc aat ttg gat aca ggg gtg cca cca agg ttc agt        192
Ile Tyr Asp Val Ser Asn Leu Asp Thr Gly Val Pro Pro Arg Phe Ser           
    50                  55                  60                            

gga agt gga tct ggg aca aat ttc act ttc acc atc agc agc ctg cag        240
Gly Ser Gly Ser Gly Thr Asn Phe Thr Phe Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

cct gaa gat att gca gtt tat tac tgt caa cag tat gaa gga ctc cct        288
Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln Tyr Glu Gly Leu Pro           
                85                  90                  95                

gtg acc ttc ggc ggg ggg acc aag gtg gag atc aaa                        324
Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                           
            100                 105                                       


<210>  42
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  42

Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asn Arg Ile Thr Phe Thr Cys Gln Ala Ser Gln Asp Ile Arg Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Val Ser Asn Leu Asp Thr Gly Val Pro Pro Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asn Phe Thr Phe Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln Tyr Glu Gly Leu Pro 
                85                  90                  95      


Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  43
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-308.46E9-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (157)..(204)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (301)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  43
tgc cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg         48
Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser           
1               5                   10                  15                

gag acc ctg tcc ctc act tgc act gtc tct ggt gcc tcc atc agc ggt         96
Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Gly           
            20                  25                  30                    

agt acc tac tac tgg ggc tgg atc cgc cag ccc cca ggg aag ggg ctg        144
Ser Thr Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu           
        35                  40                  45                        

gag tat att ggg aga atc tac tat agt ggg agc acc tac tac aac ccg        192
Glu Tyr Ile Gly Arg Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro           
    50                  55                  60                            

tcc ctc aag agt cga gcc acc ata tct gta gac acg tcc aag aac cag        240
Ser Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln           
65                  70                  75                  80            

ctc tcc ctg aca ctg agt tct gtg acc gcc gca gat acg gct gtg tat        288
Leu Ser Leu Thr Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr           
                85                  90                  95                

tat tgt gtg aga ccc ttt tac gct ggt tcg ggg aac tcc ccc ttt gac        336
Tyr Cys Val Arg Pro Phe Tyr Ala Gly Ser Gly Asn Ser Pro Phe Asp           
            100                 105                 110                   

tac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  44
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  44

Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Gly 
            20                  25                  30          


Ser Thr Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Tyr Ile Gly Arg Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro 
    50                  55                  60                  


Ser Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Leu Ser Leu Thr Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Pro Phe Tyr Ala Gly Ser Gly Asn Ser Pro Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  45
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-308.46E9 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  45
tgc gaa att gtg ctg act cag tct cca gcc acc gtg tct gtg tct cca         48
Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Val Ser Val Ser Pro           
1               5                   10                  15                

ggg gag aga gcc acc ctc tcc tgc agg gcc agc cag agt gtt agc acc         96
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr           
            20                  25                  30                    

aac tta gcc tgg tac cag cag aaa cct ggc cag cct ccc agg ctc ctc        144
Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu           
        35                  40                  45                        

att tat ggt gca tcc acc agg gcc act ggt atc cca gcc agg ttc agt        192
Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg gca gag ttc acc ctc acc atc agc agc ctg cag        240
Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

tct gaa gat ttt gtt gtt tat tac tgt cag caa tat aat aac tgg cct        288
Ser Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro           
                85                  90                  95                

ccg gct ttc ggc gga ggg acc aag gtg gaa atc aaa                        324
Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                           
            100                 105                                       


<210>  46
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  46

Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Val Ser Val Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro 
                85                  90                  95      


Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  47
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-308.46E9 VH-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (157)..(204)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (301)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  47
tgc cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg         48
Cys Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser           
1               5                   10                  15                

gag acc ctg tcc ctc act tgc act gtc tct ggt gcc tcc atc agc ggt         96
Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Gly           
            20                  25                  30                    

agt acc tac tac tgg ggc tgg atc cgc cag ccc cca ggg aag ggg ctg        144
Ser Thr Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu           
        35                  40                  45                        

gag tat att ggg aga atc tac tat agt ggg agc acc tac tac aac ccg        192
Glu Tyr Ile Gly Arg Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro           
    50                  55                  60                            

tcc ctc aag agt cga gcc acc ata tct gta gac acg tcc aag aac cag        240
Ser Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln           
65                  70                  75                  80            

ctc tcc ctg aca ctg agt tct gtg acc gcc gca gat acg gct gtg tat        288
Leu Ser Leu Thr Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr           
                85                  90                  95                

tat tgt gtg aga ccc ttt tac gct ggt tcg ggg aac tcc ccc ttt gac        336
Tyr Cys Val Arg Pro Phe Tyr Ala Gly Ser Gly Asn Ser Pro Phe Asp           
            100                 105                 110                   

tac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  48
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  48

Cys Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Gly 
            20                  25                  30          


Ser Thr Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Tyr Ile Gly Arg Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro 
    50                  55                  60                  


Ser Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Leu Ser Leu Thr Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Pro Phe Tyr Ala Gly Ser Gly Asn Ser Pro Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  49
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-308.46E9 VK-PIMC variable light-kappa chain (VK) sequence 
       after correction of primer induced mutations

<220>
<221>  V_region
<222>  (73)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  49
tgc gaa ata gtg atg acg cag tct cca gcc acc gtg tct gtg tct cca         48
Cys Glu Ile Val Met Thr Gln Ser Pro Ala Thr Val Ser Val Ser Pro           
1               5                   10                  15                

ggg gag aga gcc acc ctc tcc tgc agg gcc agc cag agt gtt agc acc         96
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr           
            20                  25                  30                    

aac tta gcc tgg tac cag cag aaa cct ggc cag cct ccc agg ctc ctc        144
Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu           
        35                  40                  45                        

att tat ggt gca tcc acc agg gcc act ggt atc cca gcc agg ttc agt        192
Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg gca gag ttc acc ctc acc atc agc agc ctg cag        240
Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

tct gaa gat ttt gtt gtt tat tac tgt cag caa tat aat aac tgg cct        288
Ser Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro           
                85                  90                  95                

ccg gct ttc ggc gga ggg acc aag gtg gag atc aaa                        324
Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                           
            100                 105                                       


<210>  50
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  50

Cys Glu Ile Val Met Thr Gln Ser Pro Ala Thr Val Ser Val Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro 
                85                  90                  95      


Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  51
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(387)
<223>  NI-308.6B11-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(354)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  51
tgc gag gtg cag ctg gtg cag tct ggg gct gag gtg aag agg cct ggg         48
Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly           
1               5                   10                  15                

gcc tca gtg aag gtc tcc tgc aag gtt tcc gga tac acc ctc act gaa         96
Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu           
            20                  25                  30                    

tta tcc atg cac tgg gtg cga cag gct cct gga aaa ggg ctt gag tgg        144
Leu Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

atg gga ggt ttt gat cct gaa gat ggt gaa aca gtc tac gca cag aag        192
Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys           
    50                  55                  60                            

ttc cag ggc aga gtc acc atg acc gag gac aca tct aca gac aca gcc        240
Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala           
65                  70                  75                  80            

tac atg gag ctg agc agc ctg aga tct gag gac acg gcc ttg tat cac        288
Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr His           
                85                  90                  95                

tgt gca aca tac ggc agc agc tgg cac tgg aat gag gga aat gag ggg        336
Cys Ala Thr Tyr Gly Ser Ser Trp His Trp Asn Glu Gly Asn Glu Gly           
            100                 105                 110                   

tcc tac tac ttt gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc        384
Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser           
        115                 120                 125                       

tcg                                                                    387
Ser                                                                       
                                                                          


<210>  52
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu 
            20                  25                  30          


Leu Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr His 
                85                  90                  95      


Cys Ala Thr Tyr Gly Ser Ser Trp His Trp Asn Glu Gly Asn Glu Gly 
            100                 105                 110         


Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  53
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-308.6B11 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  53
tgc gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta         48
Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val           
1               5                   10                  15                

gga gac aga gtc acc atc act tgc cag gcg agt cag gac att agc att         96
Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Ile           
            20                  25                  30                    

tat tta aat tgg tat cag caa aaa cca ggg aaa gcc cct aag ctc ctg        144
Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tac gat gca tcc aat ttg gaa aca ggg gtc cca tca agg ttc agt        192
Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser           
    50                  55                  60                            

gga agt gga tct ggg aca gat ttt act ttc acc atc agc ggc ctg cag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Gly Leu Gln           
65                  70                  75                  80            

cct gaa gat gtt gca aga tat tat tgt caa cag tat gat gat ctc ccc        288
Pro Glu Asp Val Ala Arg Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro           
                85                  90                  95                

atc acc ttc ggc caa ggg aca cga ctg gag att aaa                        324
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys                           
            100                 105                                       


<210>  54
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  54

Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Ile 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Arg Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  55
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(387)
<223>  NI-308.6B11 VH-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(354)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  55
tgc cag gtc cag ctg gta cag tct ggg gct gag gtg aag agg cct ggg         48
Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly           
1               5                   10                  15                

gcc tca gtg aag gtc tcc tgc aag gtt tcc gga tac acc ctc act gaa         96
Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu           
            20                  25                  30                    

tta tcc atg cac tgg gtg cga cag gct cct gga aaa ggg ctt gag tgg        144
Leu Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

atg gga ggt ttt gat cct gaa gat ggt gaa aca gtc tac gca cag aag        192
Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys           
    50                  55                  60                            

ttc cag ggc aga gtc acc atg acc gag gac aca tct aca gac aca gcc        240
Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala           
65                  70                  75                  80            

tac atg gag ctg agc agc ctg aga tct gag gac acg gcc ttg tat cac        288
Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr His           
                85                  90                  95                

tgt gca aca tac ggc agc agc tgg cac tgg aat gag gga aat gag ggg        336
Cys Ala Thr Tyr Gly Ser Ser Trp His Trp Asn Glu Gly Asn Glu Gly           
            100                 105                 110                   

tcc tac tac ttt gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc        384
Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser           
        115                 120                 125                       

tcg                                                                    387
Ser                                                                       
                                                                          


<210>  56
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  56

Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu 
            20                  25                  30          


Leu Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr His 
                85                  90                  95      


Cys Ala Thr Tyr Gly Ser Ser Trp His Trp Asn Glu Gly Asn Glu Gly 
            100                 105                 110         


Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  57
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-308.46F8-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  57
tgc cag gtg cag ctg gtg gag tct ggg gga ggt gtg gta cgg cct ggg         48
Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly           
1               5                   10                  15                

ggg tcc ctg aga ctc tcc tgt aca gcc tct gga ttc acg ttt gat gaa         96
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Glu           
            20                  25                  30                    

tat ggc atg agc tgg gtc cgc caa gtt cca ggg aag ggg ctg gag tgg        144
Tyr Gly Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

gtc tct ggc att aat tgg aat gga gca acc aca cgt tat gca gac tct        192
Val Ser Gly Ile Asn Trp Asn Gly Ala Thr Thr Arg Tyr Ala Asp Ser           
    50                  55                  60                            

gtg aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tcc ctc        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu           
65                  70                  75                  80            

tat ctg caa atg aac agt ctg aga gcc gag gac acg gcc ttg tat cac        288
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His           
                85                  90                  95                

tgt gcg aga gat ggg tgt agg aat acc agc tgc tat atc tgg gac tgg        336
Cys Ala Arg Asp Gly Cys Arg Asn Thr Ser Cys Tyr Ile Trp Asp Trp           
            100                 105                 110                   

ttc gat ccc tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                378
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  58
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  58

Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Glu 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Ala Thr Thr Arg Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His 
                85                  90                  95      


Cys Ala Arg Asp Gly Cys Arg Asn Thr Ser Cys Tyr Ile Trp Asp Trp 
            100                 105                 110         


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  59
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-308.46F8 VK variable light-lambda chain (VL) sequence

<220>
<221>  V_region
<222>  (70)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(303)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  59
tgc cag tct gtg ttg acg cag ccg ccc tca gtg tct gcg gcc cca gga         48
Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly           
1               5                   10                  15                

cag aag gtc acc atc tcc tgc tct gga agc agc tcc aac att gga aat         96
Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn           
            20                  25                  30                    

aat tat gta tgc tgg tac cag aac ctc cca gga aca gcc ccc aaa ctc        144
Asn Tyr Val Cys Trp Tyr Gln Asn Leu Pro Gly Thr Ala Pro Lys Leu           
        35                  40                  45                        

ctc att tat gac gat aat aag cga ccc tca ggg att cct gac cga ttc        192
Leu Ile Tyr Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc acg tca gcc acc ctg ggc atc acc gga ctc        240
Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu           
65                  70                  75                  80            

cag act ggg gac gag gcc gat tat tac tgc gga aca tgg gac agc agc        288
Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser           
                85                  90                  95                

ctg agt gtt gtg gta ttc ggc gga ggg acc aag ctg acc gtc cta            333
Leu Ser Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu               
            100                 105                 110                   


<210>  60
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  60

Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly 
1               5                   10                  15      


Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn 
            20                  25                  30          


Asn Tyr Val Cys Trp Tyr Gln Asn Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  61
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-308.46F8 VH-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (79)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1 according to the
       numbering conventions set forth by Kabat et al. 1983

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  61
tgc gag gtg cag ctg gtg gag tct ggg gga ggt gtg gta cgg cct ggg         48
Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly           
1               5                   10                  15                

ggg tcc ctg aga ctc tcc tgt aca gcc tct gga ttc acg ttt gat gaa         96
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Glu           
            20                  25                  30                    

tat ggc atg agc tgg gtc cgc caa gtt cca ggg aag ggg ctg gag tgg        144
Tyr Gly Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

gtc tct ggc att aat tgg aat gga gca acc aca cgt tat gca gac tct        192
Val Ser Gly Ile Asn Trp Asn Gly Ala Thr Thr Arg Tyr Ala Asp Ser           
    50                  55                  60                            

gtg aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tcc ctc        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu           
65                  70                  75                  80            

tat ctg caa atg aac agt ctg aga gcc gag gac acg gcc ttg tat cac        288
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His           
                85                  90                  95                

tgt gcg aga gat ggg tgt agg aat acc agc tgc tat atc tgg gac tgg        336
Cys Ala Arg Asp Gly Cys Arg Asn Thr Ser Cys Tyr Ile Trp Asp Trp           
            100                 105                 110                   

ttc gat ccc tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                378
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  62
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  62

Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Glu 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Ala Thr Thr Arg Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His 
                85                  90                  95      


Cys Ala Arg Asp Gly Cys Arg Asn Thr Ser Cys Tyr Ile Trp Asp Trp 
            100                 105                 110         


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  63
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  NI-308.4M1-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (155)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(348)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  63
tgc gag gtg cag ctg gtg gag act ggg gga ggc gtg gtc cag ccg ggg         48
Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly           
1               5                   10                  15                

ggg tcc ctg cga ctc tcc tgt gaa gcc tct gga ttc acc atc ggc acc         96
Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Ile Gly Thr           
            20                  25                  30                    

tat gcc atg cac tgg gtc cgc cag ttt cca ggc aag ggc ctg gat tgg        144
Tyr Ala Met His Trp Val Arg Gln Phe Pro Gly Lys Gly Leu Asp Trp           
        35                  40                  45                        

gtg gca gta ata tcg ttc gat gga act act gag tac tac aca gac gcc        192
Val Ala Val Ile Ser Phe Asp Gly Thr Thr Glu Tyr Tyr Thr Asp Ala           
    50                  55                  60                            

gtg aag ggc cga ttc acc atc tcc aga gac aat gcc aag aac aca ctg        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu           
65                  70                  75                  80            

tat ctg caa atg aac tac ttg aga ggt gac gac acg gct ata tat ttc        288
Tyr Leu Gln Met Asn Tyr Leu Arg Gly Asp Asp Thr Ala Ile Tyr Phe           
                85                  90                  95                

tgt gcg cga gat ttc acc tcc tcg ggg gag acc ggt tcg tgg aca caa        336
Cys Ala Arg Asp Phe Thr Ser Ser Gly Glu Thr Gly Ser Trp Thr Gln           
            100                 105                 110                   

gta cct gat ctc tgg ggc cag ggc acc ctg gtc acc gtc tcc tcg            381
Val Pro Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  64
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  64

Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Ile Gly Thr 
            20                  25                  30          


Tyr Ala Met His Trp Val Arg Gln Phe Pro Gly Lys Gly Leu Asp Trp 
        35                  40                  45              


Val Ala Val Ile Ser Phe Asp Gly Thr Thr Glu Tyr Tyr Thr Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Tyr Leu Arg Gly Asp Asp Thr Ala Ile Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Phe Thr Ser Ser Gly Glu Thr Gly Ser Trp Thr Gln 
            100                 105                 110         


Val Pro Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  65
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-308.4M1 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(297)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  65
tgc gaa att gtg atg aca cag tct cca gcc acc ctg tct ctg tct cca         48
Cys Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro           
1               5                   10                  15                

ggg gaa aga gcc acg ctc tcc tgc agg gcc agt cag agt gtt act aaa         96
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Lys           
            20                  25                  30                    

tac tta gcc tgg tac caa cag aaa cct ggc cag gct ccc agg ctc ctc        144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat gat gta tct tac agg gcc gct ggc acc cca gcc agg ttc agt        192
Ile Tyr Asp Val Ser Tyr Arg Ala Ala Gly Thr Pro Ala Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc agc cta gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtt tat tac tgt cac caa cgt agc agc tgg cct        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Ser Trp Pro           
                85                  90                  95                

ccg gtc act ttc ggc gga ggg acc aag gtg gag atc aaa                    327
Pro Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                       
            100                 105                                       


<210>  66
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  66

Cys Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Lys 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Val Ser Tyr Arg Ala Ala Gly Thr Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Ser Trp Pro 
                85                  90                  95      


Pro Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  67
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  NI-308.4M1 VH-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (94)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (155)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(348)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  67
tgc cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag ccg ggg         48
Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly           
1               5                   10                  15                

ggg tcc ctg cga ctc tcc tgt gaa gcc tct gga ttc acc atc ggc acc         96
Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Ile Gly Thr           
            20                  25                  30                    

tat gcc atg cac tgg gtc cgc cag ttt cca ggc aag ggc ctg gat tgg        144
Tyr Ala Met His Trp Val Arg Gln Phe Pro Gly Lys Gly Leu Asp Trp           
        35                  40                  45                        

gtg gca gta ata tcg ttc gat gga act act gag tac tac aca gac gcc        192
Val Ala Val Ile Ser Phe Asp Gly Thr Thr Glu Tyr Tyr Thr Asp Ala           
    50                  55                  60                            

gtg aag ggc cga ttc acc atc tcc aga gac aat gcc aag aac aca ctg        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu           
65                  70                  75                  80            

tat ctg caa atg aac tac ttg aga ggt gac gac acg gct ata tat ttc        288
Tyr Leu Gln Met Asn Tyr Leu Arg Gly Asp Asp Thr Ala Ile Tyr Phe           
                85                  90                  95                

tgt gcg cga gat ttc acc tcc tcg ggg gag acc ggt tcg tgg aca caa        336
Cys Ala Arg Asp Phe Thr Ser Ser Gly Glu Thr Gly Ser Trp Thr Gln           
            100                 105                 110                   

gta cct gat ctc tgg ggc cag ggc acc ctg gtc acc gtc tcc tcg            381
Val Pro Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  68
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  68

Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Ile Gly Thr 
            20                  25                  30          


Tyr Ala Met His Trp Val Arg Gln Phe Pro Gly Lys Gly Leu Asp Trp 
        35                  40                  45              


Val Ala Val Ile Ser Phe Asp Gly Thr Thr Glu Tyr Tyr Thr Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Tyr Leu Arg Gly Asp Asp Thr Ala Ile Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Phe Thr Ser Ser Gly Glu Thr Gly Ser Trp Thr Gln 
            100                 105                 110         


Val Pro Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  69
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-308.4M1 VK-PIMC variable light-kappa chain (VK) sequence after
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (73)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(297)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  69
tgc gaa att gtg ttg aca cag tct cca gcc acc ctg tct ctg tct cca         48
Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro           
1               5                   10                  15                

ggg gaa aga gcc acg ctc tcc tgc agg gcc agt cag agt gtt act aaa         96
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Lys           
            20                  25                  30                    

tac tta gcc tgg tac caa cag aaa cct ggc cag gct ccc agg ctc ctc        144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat gat gta tct tac agg gcc gct ggc acc cca gcc agg ttc agt        192
Ile Tyr Asp Val Ser Tyr Arg Ala Ala Gly Thr Pro Ala Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc agc cta gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtt tat tac tgt cac caa cgt agc agc tgg cct        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Ser Trp Pro           
                85                  90                  95                

ccg gtc act ttc ggc gga ggg acc aag gtg gag atc aaa                    327
Pro Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                       
            100                 105                                       


<210>  70
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  70

Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Lys 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Val Ser Tyr Arg Ala Ala Gly Thr Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Ser Trp Pro 
                85                  90                  95      


Pro Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  71
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-308.12A3-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(208)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  71
tgc gag gtg cag ctg gtg gag act ggg gga ggc ttg gta cag cct gga         48
Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly           
1               5                   10                  15                

ggg tcc ctg aga ctc tcc tgc gta ggc tct gga ttt ctc ttc agt gat         96
Gly Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Leu Phe Ser Asp           
            20                  25                  30                    

ttt gaa atg gac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg        144
Phe Glu Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att tca tat att agt ggt gac ggt aat atc ata tat cag aca gac tct        192
Ile Ser Tyr Ile Ser Gly Asp Gly Asn Ile Ile Tyr Gln Thr Asp Ser           
    50                  55                  60                            

gtg aag ggc cga ttc acc atc tcc aga gac aac gcc aag aat tca ctg        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu           
65                  70                  75                  80            

ttt cta caa atg gac agc ctg acc gtc gag gac acg gct gta tat tac        288
Phe Leu Gln Met Asp Ser Leu Thr Val Glu Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga gac gcc cgt gaa aac tgt ggt ggt gac tgc tat tcc acg        336
Cys Ala Arg Asp Ala Arg Glu Asn Cys Gly Gly Asp Cys Tyr Ser Thr           
            100                 105                 110                   

tcc ttt gat ttt tgg ggc cag ggc acc ctg gtc acc gtc tcctcg             381
Ser Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val                       
        115                 120                 125                       


<210>  72
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  72

Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Leu Phe Ser Asp 
            20                  25                  30          


Phe Glu Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ser Tyr Ile Ser Gly Asp Gly Asn Ile Ile Tyr Gln Thr Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asp Ser Leu Thr Val Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ala Arg Glu Asn Cys Gly Gly Asp Cys Tyr Ser Thr 
            100                 105                 110         


Ser Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125 


<210>  73
<211>  342
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(315)
<223>  NI-308.12A3 VK  variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(108)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(285)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  73
tgc gac atc cag atg acc cag tct cca gac tcc ctg gct gtg tct ctg         48
Cys Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu           
1               5                   10                  15                

ggc gag agg gcc acc atc aac tgc aag tcc agc cag agt ctt tta tac         96
Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr           
            20                  25                  30                    

act gcc aac aat agg aac tac tta gcc tgg tac cag aaa aaa gca gga        144
Thr Ala Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Lys Lys Ala Gly           
        35                  40                  45                        

cag cct cct aag ctc ctc att cac tgg gca tct acc cgg gca tcc ggg        192
Gln Pro Pro Lys Leu Leu Ile His Trp Ala Ser Thr Arg Ala Ser Gly           
    50                  55                  60                            

gtc cct gac cga ttc agt ggc agc ggg tct ggg aca gat ttc att ctc        240
Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu           
65                  70                  75                  80            

acc atc agc agc ctg cag gct gaa gat gtg gca gtt tat ttt tgt caa        288
Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln           
                85                  90                  95                

cat tat tat aat tct ccc cgg acg ttc ggccaaggga ccaaggtgga gatcaaa      342
His Tyr Tyr Asn Ser Pro Arg Thr Phe                                       
            100                 105                                       


<210>  74
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  74

Cys Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr 
            20                  25                  30          


Thr Ala Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Lys Lys Ala Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile His Trp Ala Ser Thr Arg Ala Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln 
                85                  90                  95      


His Tyr Tyr Asn Ser Pro Arg Thr Phe 
            100                 105 


<210>  75
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-308.12A3 VH-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (91)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  75
tgc gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct gga         48
Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly           
1               5                   10                  15                

ggg tcc ctg aga ctc tcc tgc gta ggc tct gga ttt ctc ttc agt gat         96
Gly Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Leu Phe Ser Asp           
            20                  25                  30                    

ttt gaa atg gac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg        144
Phe Glu Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att tca tat att agt ggt gac ggt aat atc ata tat cag aca gac tct        192
Ile Ser Tyr Ile Ser Gly Asp Gly Asn Ile Ile Tyr Gln Thr Asp Ser           
    50                  55                  60                            

gtg aag ggc cga ttc acc atc tcc aga gac aac gcc aag aat tca ctg        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu           
65                  70                  75                  80            

ttt cta caa atg gac agc ctg acc gtc gag gac acg gct gta tat tac        288
Phe Leu Gln Met Asp Ser Leu Thr Val Glu Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga gac gcc cgt gaa aac tgt ggt ggt gac tgc tat tcc acg        336
Cys Ala Arg Asp Ala Arg Glu Asn Cys Gly Gly Asp Cys Tyr Ser Thr           
            100                 105                 110                   

tcc ttt gat ttt tgg ggc cag ggc acc ctg gtc acc gtc tcctcg             381
Ser Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val                       
        115                 120                 125                       


<210>  76
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  76

Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Leu Phe Ser Asp 
            20                  25                  30          


Phe Glu Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ser Tyr Ile Ser Gly Asp Gly Asn Ile Ile Tyr Gln Thr Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asp Ser Leu Thr Val Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ala Arg Glu Asn Cys Gly Gly Asp Cys Tyr Ser Thr 
            100                 105                 110         


Ser Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125 


<210>  77
<211>  342
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(315)
<223>  NI-308.12A3 VK-PIMC variable light-kappa chain (VK) sequence 
       after correction of primer induced mutations

<220>
<221>  V_region
<222>  (73)..(108)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(285)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  77
tgc gac atc gtg atg acc cag tct cca gac tcc ctg gct gtg tct ctg         48
Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu           
1               5                   10                  15                

ggc gag agg gcc acc atc aac tgc aag tcc agc cag agt ctt tta tac         96
Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr           
            20                  25                  30                    

act gcc aac aat agg aac tac tta gcc tgg tac cag aaa aaa gca gga        144
Thr Ala Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Lys Lys Ala Gly           
        35                  40                  45                        

cag cct cct aag ctc ctc att cac tgg gca tct acc cgg gca tcc ggg        192
Gln Pro Pro Lys Leu Leu Ile His Trp Ala Ser Thr Arg Ala Ser Gly           
    50                  55                  60                            

gtc cct gac cga ttc agt ggc agc ggg tct ggg aca gat ttc att ctc        240
Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu           
65                  70                  75                  80            

acc atc agc agc ctg cag gct gaa gat gtg gca gtt tat ttt tgt caa        288
Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln           
                85                  90                  95                

cat tat tat aat tct ccc cgg acg ttc ggccaaggga ccaaggtgga gatcaaa      342
His Tyr Tyr Asn Ser Pro Arg Thr Phe                                       
            100                 105                                       


<210>  78
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  78

Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr 
            20                  25                  30          


Thr Ala Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Lys Lys Ala Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile His Trp Ala Ser Thr Arg Ala Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln 
                85                  90                  95      


His Tyr Tyr Asn Ser Pro Arg Thr Phe 
            100                 105 


<210>  79
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-308.16C10-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  79
tgc gag gtg cag ctg gtg gag act ggg gga ggc gtg gtc cag cct ggg         48
Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly           
1               5                   10                  15                

atg tcc ctg agc ctc tcc tgt gca gcg act gga ttc acc ttc agc agt         96
Met Ser Leu Ser Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Ser Ser           
            20                  25                  30                    

tat ggc atg cac tgg gtc cgc caa ggt cca ggc aag ggg ccg gag tgg        144
Tyr Gly Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu Trp           
        35                  40                  45                        

gtg gcg ggt ata tgg tac gat gga aca aat aag tat tat gga gac tcc        192
Val Ala Gly Ile Trp Tyr Asp Gly Thr Asn Lys Tyr Tyr Gly Asp Ser           
    50                  55                  60                            

gtg acg ggc aga gtc acc atc tcc aga gac aac tcc aag aac acg ctg        240
Val Thr Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu           
65                  70                  75                  80            

ttt ctg caa atg atc aac gtg aga gtc gag gac acg gct gtg tat tac        288
Phe Leu Gln Met Ile Asn Val Arg Val Glu Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gtg aag gat gca gag cgc gtc cag aaa tgg gct agt tac att atg        336
Cys Val Lys Asp Ala Glu Arg Val Gln Lys Trp Ala Ser Tyr Ile Met           
            100                 105                 110                   

gac gtg tgg ggc caa ggg acc acg gtc acc gtc tcc tcg                    375
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  80
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  80

Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Met Ser Leu Ser Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu Trp 
        35                  40                  45              


Val Ala Gly Ile Trp Tyr Asp Gly Thr Asn Lys Tyr Tyr Gly Asp Ser 
    50                  55                  60                  


Val Thr Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Ile Asn Val Arg Val Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Lys Asp Ala Glu Arg Val Gln Lys Trp Ala Ser Tyr Ile Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  81
<211>  315
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(315)
<223>  NI-308.16C10 VK  variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (73)..(108)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(285)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  81
tgc gaa att gtg ctg act cag tct cca ggc atc ctg tct ttg tct cga         48
Cys Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Arg           
1               5                   10                  15                

ggg aat cgg gtc gcc ctc tcc tgc agg gcc agt cgg agt gtt aat agc         96
Gly Asn Arg Val Ala Leu Ser Cys Arg Ala Ser Arg Ser Val Asn Ser           
            20                  25                  30                    

agc tac tta aat tgg tac cag caa aaa cca ggc cag gct ccc aga ctc        144
Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu           
        35                  40                  45                        

ctc atc tat ggt gca tct aaa agg gcc act ggc atc tca gac agg ttc        192
Leu Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Ile Ser Asp Arg Phe           
    50                  55                  60                            

cgt ggc act ggg tct ggg aca gac ttc act ctc acc gtc gcc aga ctg        240
Arg Gly Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ala Arg Leu           
65                  70                  75                  80            

gag cct gaa gat att gcg gtt tac tac tgt cag cac tat ggt gcc ttc        288
Glu Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln His Tyr Gly Ala Phe           
                85                  90                  95                

ggc caa ggg acc aag ctg gag atc aaa                                    315
Gly Gln Gly Thr Lys Leu Glu Ile Lys                                       
            100                 105                                       


<210>  82
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  82

Cys Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Arg 
1               5                   10                  15      


Gly Asn Arg Val Ala Leu Ser Cys Arg Ala Ser Arg Ser Val Asn Ser 
            20                  25                  30          


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Ile Ser Asp Arg Phe 
    50                  55                  60                  


Arg Gly Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ala Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln His Tyr Gly Ala Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  83
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-308.16C10 VH-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (91)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  83
tgc cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg         48
Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly           
1               5                   10                  15                

atg tcc ctg agc ctc tcc tgt gca gcg act gga ttc acc ttc agc agt         96
Met Ser Leu Ser Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Ser Ser           
            20                  25                  30                    

tat ggc atg cac tgg gtc cgc caa ggt cca ggc aag ggg ccg gag tgg        144
Tyr Gly Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu Trp           
        35                  40                  45                        

gtg gcg ggt ata tgg tac gat gga aca aat aag tat tat gga gac tcc        192
Val Ala Gly Ile Trp Tyr Asp Gly Thr Asn Lys Tyr Tyr Gly Asp Ser           
    50                  55                  60                            

gtg acg ggc aga gtc acc atc tcc aga gac aac tcc aag aac acg ctg        240
Val Thr Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu           
65                  70                  75                  80            

ttt ctg caa atg atc aac gtg aga gtc gag gac acg gct gtg tat tac        288
Phe Leu Gln Met Ile Asn Val Arg Val Glu Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gtg aag gat gca gag cgc gtc cag aaa tgg gct agt tac att atg        336
Cys Val Lys Asp Ala Glu Arg Val Gln Lys Trp Ala Ser Tyr Ile Met           
            100                 105                 110                   

gac gtg tgg ggc caa ggg acc acg gtc acc gtc tcc tcg                    375
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  84
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  84

Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Met Ser Leu Ser Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu Trp 
        35                  40                  45              


Val Ala Gly Ile Trp Tyr Asp Gly Thr Asn Lys Tyr Tyr Gly Asp Ser 
    50                  55                  60                  


Val Thr Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Ile Asn Val Arg Val Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Lys Asp Ala Glu Arg Val Gln Lys Trp Ala Ser Tyr Ile Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  85
<211>  315
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(315)
<223>  NI-308.16C10 VK-PIMC variable light-kappa chain (VK) sequence 
       after correction of primer induced mutations

<220>
<221>  V_region
<222>  (73)..(108)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(285)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  85
tgc gaa att gtg ttg acg cag tct cca ggc acc ctg tct ttg tct cga         48
Cys Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Arg           
1               5                   10                  15                

ggg aat cgg gtc gcc ctc tcc tgc agg gcc agt cgg agt gtt aat agc         96
Gly Asn Arg Val Ala Leu Ser Cys Arg Ala Ser Arg Ser Val Asn Ser           
            20                  25                  30                    

agc tac tta aat tgg tac cag caa aaa cca ggc cag gct ccc aga ctc        144
Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu           
        35                  40                  45                        

ctc atc tat ggt gca tct aaa agg gcc act ggc atc tca gac agg ttc        192
Leu Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Ile Ser Asp Arg Phe           
    50                  55                  60                            

cgt ggc act ggg tct ggg aca gac ttc act ctc acc gtc gcc aga ctg        240
Arg Gly Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ala Arg Leu           
65                  70                  75                  80            

gag cct gaa gat att gcg gtt tac tac tgt cag cac tat ggt gcc ttc        288
Glu Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln His Tyr Gly Ala Phe           
                85                  90                  95                

ggc caa ggg acc aag gtg gaa atc aaa                                    315
Gly Gln Gly Thr Lys Val Glu Ile Lys                                       
            100                 105                                       


<210>  86
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  86

Cys Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Arg 
1               5                   10                  15      


Gly Asn Arg Val Ala Leu Ser Cys Arg Ala Ser Arg Ser Val Asn Ser 
            20                  25                  30          


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Ile Ser Asp Arg Phe 
    50                  55                  60                  


Arg Gly Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ala Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln His Tyr Gly Ala Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105 


