                         SEQUENCE LISTING

<110>  UNIVERSITE DE MONTREAL
       RSEM, LIMITED PARTNERSHIP
       SAUVAGEAU, Guy
       LAVALLE, Vincent-Philippe
       HBERT, Jose
       LEMIEUX, Sbastien
 
<120>  Markers for poor prognosis acute myeloid leukemias (AMLs) and 
       uses thereof

<130>  782/15691.76

<150>  US 62/058,916
<151>  2014-10-02

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
tggagataac actctaagca taactaaagg t                                      31


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
gatgtagttg cttgggaccc a                                                 21


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
tggtcaacat ccctgccg                                                     18


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
ttgcatcttc tcgtttccgc                                                   20


<210>  5
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
ccatttttgg tttgggcttc acaccatt                                          28


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
agtacgaaga tgatgaagca gggc                                              24


<210>  7
<211>  1967
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (287)..(1309)

<400>  7
ctgtcctggg attgcctgga gctccgcacc gcgagtttgc cgcggcactt tccgcgcggc       60

ggaagagcgc gcgccagctt cggcacacct gggagccgga tcccagccct acgcctcgtc      120

ccctacaagc tcctccaagc cccgccggct gctgtgggag cggcggccgt ccctctcctg      180

gaggtcgtct cctggcatcc tcggggccgc aggaaggaag aggaggcagc ggccggagcc      240

ctggtgggcg gcctgaggtg agagcccgac cggccccttt gggaat atg gcg acc         295
                                                   Met Ala Thr            
                                                   1                      

ggt ggc tac cgg acc agc agc ggc ctc ggc ggc agc acc aca gac ttc        343
Gly Gly Tyr Arg Thr Ser Ser Gly Leu Gly Gly Ser Thr Thr Asp Phe           
    5                   10                  15                            

ctg gag gag tgg aag gcg aaa cgc gag aag atg cgc gcc aag cag aac        391
Leu Glu Glu Trp Lys Ala Lys Arg Glu Lys Met Arg Ala Lys Gln Asn           
20                  25                  30                  35            

ccc ccg ggc ccg gcc ccc ccg gga ggg ggc agc agc gac gcc gct ggg        439
Pro Pro Gly Pro Ala Pro Pro Gly Gly Gly Ser Ser Asp Ala Ala Gly           
                40                  45                  50                

aag ccc ccc gcg ggg gct ctg ggc acc ccg gcg gcc gcc gct gcc aac        487
Lys Pro Pro Ala Gly Ala Leu Gly Thr Pro Ala Ala Ala Ala Ala Asn           
            55                  60                  65                    

gag ctc aac aac aac ctc ccg ggc ggc gcg ccg gcc gca cct gcc gtc        535
Glu Leu Asn Asn Asn Leu Pro Gly Gly Ala Pro Ala Ala Pro Ala Val           
        70                  75                  80                        

ccc ggt ccc ggg ggc gtg aac tgc gcg gtc ggc tcc gcc atg ctg acg        583
Pro Gly Pro Gly Gly Val Asn Cys Ala Val Gly Ser Ala Met Leu Thr           
    85                  90                  95                            

cgg gcg gcc ccc ggc ccg cgg cgg tcg gag gac gag ccc cca gcc gcc        631
Arg Ala Ala Pro Gly Pro Arg Arg Ser Glu Asp Glu Pro Pro Ala Ala           
100                 105                 110                 115           

tct gcc tcg gct gca ccg ccg ccc cag cgt gac gag gag gag ccg gac        679
Ser Ala Ser Ala Ala Pro Pro Pro Gln Arg Asp Glu Glu Glu Pro Asp           
                120                 125                 130               

ggc gtc cca gag aag ggc aag agc tcg ggc ccc agt gcc agg aaa ggc        727
Gly Val Pro Glu Lys Gly Lys Ser Ser Gly Pro Ser Ala Arg Lys Gly           
            135                 140                 145                   

aag ggg cag atc gag aag agg aag ctg cgg gag aag cgg cgc tcc acc        775
Lys Gly Gln Ile Glu Lys Arg Lys Leu Arg Glu Lys Arg Arg Ser Thr           
        150                 155                 160                       

ggc gtg gtc aac atc cct gcc gca gag tgc tta gat gag tac gaa gat        823
Gly Val Val Asn Ile Pro Ala Ala Glu Cys Leu Asp Glu Tyr Glu Asp           
    165                 170                 175                           

gat gaa gca ggg cag aaa gag cgg aaa cga gaa gat gca att aca caa        871
Asp Glu Ala Gly Gln Lys Glu Arg Lys Arg Glu Asp Ala Ile Thr Gln           
180                 185                 190                 195           

cag aac act att cag aat gaa gct gta aac tta cta gat cca ggc agt        919
Gln Asn Thr Ile Gln Asn Glu Ala Val Asn Leu Leu Asp Pro Gly Ser           
                200                 205                 210               

tcc tat ctg cta cag gag cca cct aga aca gtt tca ggc aga tat aaa        967
Ser Tyr Leu Leu Gln Glu Pro Pro Arg Thr Val Ser Gly Arg Tyr Lys           
            215                 220                 225                   

agc aca acc agt gtc tct gaa gaa gat gtc tca agt aga tat tct cga       1015
Ser Thr Thr Ser Val Ser Glu Glu Asp Val Ser Ser Arg Tyr Ser Arg           
        230                 235                 240                       

aca gat aga agt ggg ttc cct aga tat aac agg gat gca aat gtt tca       1063
Thr Asp Arg Ser Gly Phe Pro Arg Tyr Asn Arg Asp Ala Asn Val Ser           
    245                 250                 255                           

ggt act ctg gtt tca agt agc aca ctg gaa aag aaa att gaa gat ctt       1111
Gly Thr Leu Val Ser Ser Ser Thr Leu Glu Lys Lys Ile Glu Asp Leu           
260                 265                 270                 275           

gaa aag gaa gta gta aga gaa aga caa gaa aac cta aga ctt gtg aga       1159
Glu Lys Glu Val Val Arg Glu Arg Gln Glu Asn Leu Arg Leu Val Arg           
                280                 285                 290               

ctg atg caa gat aaa gag gaa atg att gga aaa ctc aaa gaa gaa att       1207
Leu Met Gln Asp Lys Glu Glu Met Ile Gly Lys Leu Lys Glu Glu Ile           
            295                 300                 305                   

gat tta tta aat aga gac cta gat gac ata gaa gat gaa aat gaa cag       1255
Asp Leu Leu Asn Arg Asp Leu Asp Asp Ile Glu Asp Glu Asn Glu Gln           
        310                 315                 320                       

cta aag cag gaa aat aaa act ctt ttg aaa gtt gtg ggt cag ctg acc       1303
Leu Lys Gln Glu Asn Lys Thr Leu Leu Lys Val Val Gly Gln Leu Thr           
    325                 330                 335                           

agg tag aggattcaag actcaatgtg gaaaaaatat tttaaactac tgattgaatg        1359
Arg                                                                       
340                                                                       

ttaatggtca atgctagcac aatattccta tgctgcaata cattaaaata actaagcaag     1419

tatatttatt tctagcaaac agatgtttgt tttcaaaata cttctttttc attattggtt     1479

ttaaaaaagc attatccttt tatctcacaa ataagtaata tctttcagtt attaaatgat     1539

agataatgcc tttttggttt tgtgtggtat tcaactaata catggtttaa agtcacagcc     1599

gtttgaatat attttatctt ggtagtacat tttctccctt aggaatatac atagtctttg     1659

tttacatgag ttcaaatact tttgggatgt taccttcaca tgtcctatta ctgatgtgtg     1719

caacctttta tgtgttgatg actcactcat aaaggttttt gtctactgtc atttgttctt     1779

tccacttatt ctaagcattt agagtaatag agtcatactt ttttataaca gcaacctttt     1839

aaaaggaaag ctcttataaa gtcactgtca tgttttagtt gactaaatat aaatttaaga     1899

gaatacttga attgtgctat agtaaataaa aatttactat tttgtgtttg aaaaaaaaaa     1959

aaaaaaaa                                                              1967


<210>  8
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Thr Gly Gly Tyr Arg Thr Ser Ser Gly Leu Gly Gly Ser Thr 
1               5                   10                  15      


Thr Asp Phe Leu Glu Glu Trp Lys Ala Lys Arg Glu Lys Met Arg Ala 
            20                  25                  30          


Lys Gln Asn Pro Pro Gly Pro Ala Pro Pro Gly Gly Gly Ser Ser Asp 
        35                  40                  45              


Ala Ala Gly Lys Pro Pro Ala Gly Ala Leu Gly Thr Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Asn Glu Leu Asn Asn Asn Leu Pro Gly Gly Ala Pro Ala Ala 
65                  70                  75                  80  


Pro Ala Val Pro Gly Pro Gly Gly Val Asn Cys Ala Val Gly Ser Ala 
                85                  90                  95      


Met Leu Thr Arg Ala Ala Pro Gly Pro Arg Arg Ser Glu Asp Glu Pro 
            100                 105                 110         


Pro Ala Ala Ser Ala Ser Ala Ala Pro Pro Pro Gln Arg Asp Glu Glu 
        115                 120                 125             


Glu Pro Asp Gly Val Pro Glu Lys Gly Lys Ser Ser Gly Pro Ser Ala 
    130                 135                 140                 


Arg Lys Gly Lys Gly Gln Ile Glu Lys Arg Lys Leu Arg Glu Lys Arg 
145                 150                 155                 160 


Arg Ser Thr Gly Val Val Asn Ile Pro Ala Ala Glu Cys Leu Asp Glu 
                165                 170                 175     


Tyr Glu Asp Asp Glu Ala Gly Gln Lys Glu Arg Lys Arg Glu Asp Ala 
            180                 185                 190         


Ile Thr Gln Gln Asn Thr Ile Gln Asn Glu Ala Val Asn Leu Leu Asp 
        195                 200                 205             


Pro Gly Ser Ser Tyr Leu Leu Gln Glu Pro Pro Arg Thr Val Ser Gly 
    210                 215                 220                 


Arg Tyr Lys Ser Thr Thr Ser Val Ser Glu Glu Asp Val Ser Ser Arg 
225                 230                 235                 240 


Tyr Ser Arg Thr Asp Arg Ser Gly Phe Pro Arg Tyr Asn Arg Asp Ala 
                245                 250                 255     


Asn Val Ser Gly Thr Leu Val Ser Ser Ser Thr Leu Glu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Glu Lys Glu Val Val Arg Glu Arg Gln Glu Asn Leu Arg 
        275                 280                 285             


Leu Val Arg Leu Met Gln Asp Lys Glu Glu Met Ile Gly Lys Leu Lys 
    290                 295                 300                 


Glu Glu Ile Asp Leu Leu Asn Arg Asp Leu Asp Asp Ile Glu Asp Glu 
305                 310                 315                 320 


Asn Glu Gln Leu Lys Gln Glu Asn Lys Thr Leu Leu Lys Val Val Gly 
                325                 330                 335     


Gln Leu Thr Arg 
            340 


<210>  9
<211>  4057
<212>  DNA
<213>  Homo sapiens

<400>  9
aaagtttgtc acttcggaca gtttcctgcc ggggcaccgt ttctacgggc gccccccgcc       60

cccagccttc tttcctcctc gcccgcagtc tcgcggagcc ctgctgctta tctacgttgc      120

taagccgggc gatttccttg ttcctcctgc gaaacggtgc ggtctggaca cgtctccggg      180

gtgggtcgtc cggccttcga tcttagacga attttacaat gtgaagttct gcatagatgc      240

cagtcaacca gatgttggaa gctggctcaa gtacattaga ttcgctggct gttatgatca      300

gcacaacctt gttgcatgcc agataaatga tcagatattc tatagagtag ttgcagacat      360

tgcgccggga gaggagcttc tgctgttcat gaagagcgaa gactatcccc atgaaactat      420

ggcgccggat atccacgaag aacggcaata tcgctgcgaa gactgtgacc agctctttga      480

atctaaggct gaactagcag atcaccaaaa gtttccatgc agtactcctc actcagcatt      540

ttcaatggtt gaagaggact ttcagcaaaa actcgaaagc gagaatgatc tccaagagat      600

acacacgatc caggagtgta aggaatgtga ccaagttttt cctgatttgc aaagcctgga      660

gaaacacatg ctgtcacata ctgaagagag ggaatacaag tgtgatcagt gtcccaaggc      720

atttaactgg aagtccaatt taattcgcca ccagatgtca catgacagtg gaaagcacta      780

tgaatgtgaa aactgtgcca agcaggtttt cacggaccct agcaaccttc agcggcacat      840

tcgctctcag catgtcggtg cccgggccca tgcatgcccg gagtgtggca aaacgtttgc      900

cacttcgtcg ggcctcaaac aacacaagca catccacagc agtgtgaagc cctttatctc      960

attctctcaa tcaatgtacc catttcctga tagagacttg agatcgttac ctttgaaaat     1020

ggaaccccaa tcaccaggtg aagtaaagaa actgcagaag ggcagctctg agtccccctt     1080

tgatctcacc actaagcgaa aggatgagaa gcccttgact ccagtcccct ccaagcctcc     1140

agtgacacct gccacaagcc aagaccagcc cctggatcta agtatgggca gtaggagtag     1200

agccagtggg acaaagctga ctgagcctcg aaaaaaccac gtgtttgggg gaaaaaaagg     1260

aagcaacgtc gaatcaagac ctgcttcaga tggttccttg cagcatgcaa gacccactcc     1320

tttctttatg gaccctattt acagagtaga gaaaagaaaa ctaactgacc cacttgaagc     1380

tttaaaagag aaatacttga ggccttctcc aggattcttg tttcacccac aattccaact     1440

gcctgatcag agaacttgga tgtcagctat tgaaaacatg gcagaaaagc tagagagctt     1500

cagtgccctg aaacctgagg ccagtgagct cttacagtca gtgccctcta tgttcaactt     1560

cagggcgcct cccaatgccc tgccagagaa ccttctgcgg aagggaaagg agcgctatac     1620

ctgcagatac tgtggcaaga tttttccaag gtctgcaaac ctaacacggc acttgagaac     1680

ccacacagga gagcagcctt acagatgcaa atactgtgac agatcattta gcatatcttc     1740

taacttgcaa aggcatgttc gcaacatcca caataaagag aagccattta agtgtcactt     1800

atgtgatagg tgttttggtc aacaaaccaa tttagacaga cacctaaaga aacatgagaa     1860

tgggaacatg tccggtacag caacatcgtc gcctcattct gaactggaaa gtacaggtgc     1920

gattctggat gacaaagaag atgcttactt cacagaaatt cgaaatttca ttgggaacag     1980

caaccatggc agccaatctc ccaggaatgt ggaggagaga atgaatggca gtcattttaa     2040

agatgaaaag gctttggtga ccagtcaaaa ttcagacttg ctggatgatg aagaagttga     2100

agatgaggtg ttgttagatg aggaggatga agacaatgat attactggaa aaacaggaaa     2160

ggaaccagtg acaagtaatt tacatgaagg aaaccctgag gatgactatg aagaaaccag     2220

tgccctggag atgagttgca agacatcccc agtgaggtat aaagaggaag aatataaaag     2280

tggactttct gctctagatc atataaggca cttcacagat agcctcaaaa tgaggaaaat     2340

ggaagataat caatattctg aagctgagct gtcttctttt agtacttccc atgtgccaga     2400

ggaacttaag cagccgttac acagaaagtc caaatcgcag gcatatgcta tgatgctgtc     2460

actgtctgac aaggagtccc tccattctac atcccacagt tcttccaacg tgtggcacag     2520

tatggccagg gctgcggcgg aatccagtgc tatccagtcc ataagccacg tatgacgtta     2580

tcaaggttga ccagagtggg accaagtcca acagtagcat ggctctttca tataggacta     2640

tttacaagac tgctgagcag aatgccttat aaacctgcag ggtcactcat ctaaagtcta     2700

gtgaccttaa actgaatgat ttaaaaaaga aaagaaagaa aaaagaaact atttattctc     2760

gatattttgt tttgcacagc aaaggcagct gctgacttct ggaagatcaa tcaatgcgac     2820

ttaaagtgat tcagtgaaaa caaaaaactt ggtgggctga aggcatcttc cagtttaccc     2880

caccttaggg tatgggtggg tgagaagggc agttgagatg gcagcattga tatgaatgaa     2940

cactccatag aaactgaatt ctcttttgta caagatcacc tgacatgatt gggaacagtt     3000

gcttttaatt acagatttaa tttttttctt cgttaaagtt ttatgtaatt taaccctttg     3060

aagacagaag tagttggatg aaatgcacag tcaattatta tagaaactga taacagggag     3120

tacttgttcc cccttttgcc ttcttaagta cattgtttaa aactagggaa aaagggtatg     3180

tgtatattgt aaactatgga tgttaacact caaagaggtt aagtcagtga agtaacctat     3240

tcatcaccag taccgctgta ccactaataa attgtttgcc aaatccttgt aataacatct     3300

taattttaga caatcatgtc actgttttta atgtttattt ttttgtgtgt gttgcgtgta     3360

tcatgtattt atttgttggc aaactattgt ttgttgatta aaatagcact gttccagtca     3420

gccactactt tatgacgtct gaggcacacc cctttccgaa tttcaaggac caaggtgacc     3480

cgacctgtgt atgagagtgc caaatggtgt ttggcttttc ttaacattcc tttttgtttg     3540

tttgttttgt tttccttctt aatgaactaa atacgaatag atgcaactta gtttttgtaa     3600

tactgaaatc gattcaattg tataaacgat tataatttct ttcatggaag catgattctt     3660

ctgattaaaa actgtactcc atattttatg ctggttgtct gcaagcttgt gcgatgttat     3720

gttcatgtta atcctatttg taaaatgaag tgttcccaac cttatgttaa aagagagaag     3780

taaataacag actgtattca gttattttgc cctttattga ggaaccagat ttgttttctt     3840

tttgtttgta atctcatttt gaaataatca gcaagttgag gtactttctt caaatgcttt     3900

gtacaatata aactgttatg cctttcagtg cattactatg ggaggagcaa ctaaaaaata     3960

aagacttaca aaaaggagta tttttcccca ctgtgtggta tttttccttc atgcaatttt     4020

actttccctt tgggatccaa tgatttaaag atatgat                              4057


<210>  10
<211>  5907
<212>  DNA
<213>  Homo sapiens

<400>  10
cacactcgcg cgcacacaca cacacacaca ccacacttgt gctttcaaga catcgaaacg       60

gaggctattt ccctggggaa agaaatcctg cctggcgaga tctccccatt ggttgtttac      120

ccggagaaat ctacatgttt aagggggatg gtgcatccat aatcagtctg tccctatagg      180

acttgggtct tggcgacctt tttgtgacct ctcccgccag aggaggctgc tgtcacttta      240

aaaatttaaa agaggagccc gtctggcttc cgatcagatc actctgggcg gcgggagata      300

gctccctttc tccctcgccc cgggttcttt ctggatggcc gagcagatcc tctttaaaga      360

gacagttcat gaaatagaaa cccggcggct gagcttggag ttgcgaaagg ggacgatccc      420

gtgagggtcc aggacccgcg aaggcgctgc ggaggatctg aaagggggat agagctcccc      480

tcgcctcccc aggcccccca ccttttcaaa ctctcctcct cctgcttgtt ttcccccatt      540

ggaactggga aggagaagta gaagttttag tgggtttcag ataactttca ttacacatcg      600

ggctgataag agcaagagaa agtgagaaaa gagggaggtg atgtgaacca gaaggaatag      660

ctccgagctc atttaggaag ggggaaaaag ccaaaacaca ccaaacccgg gtcacccaga      720

cgaaagaaga cttcatttct tgtattaaaa atacactgtt ggcggacaat aaatccgaaa      780

cgcgtggtcc tggagagcag atcctagaga cggacaaagt tgtcagagac ccatttggaa      840

atcgagacgc gaggctttta aaaaattatt attattattt ttaaacatct ctaaatgttg      900

ctcgggatcg tttgaaagga ttttcgtgca ggagcgttgg gggctgctga ttattttatt      960

ttgtttattt tgattcttct gtgaatgcct attattgctg agttgaggcc atagaaatct     1020

aaagatctta gacgaatttt acaatgtgaa gttctgcata gatgccagtc aaccagatgt     1080

tggaagctgg ctcaagtaca ttagattcgc tggctgttat gatcagcaca accttgttgc     1140

atgccagata aatgatcaga tattctatag agtagttgca gacattgcgc cgggagagga     1200

gcttctgctg ttcatgaaga gcgaagacta tccccatgaa actatggcgc cggatatcca     1260

cgaagaacgg caatatcgct gcgaagactg tgaccagctc tttgaatcta aggctgaact     1320

agcagatcac caaaagtttc catgcagtac tcctcactca gcattttcaa tggttgaaga     1380

ggactttcag caaaaactcg aaagcgagaa tgatctccaa gagatacaca cgatccagga     1440

gtgtaaggaa tgtgaccaag tttttcctga tttgcaaagc ctggagaaac acatgctgtc     1500

acatactgaa gagagggaat acaagtgtga tcagtgtccc aaggcattta actggaagtc     1560

caatttaatt cgccaccaga tgtcacatga cagtggaaag cactatgaat gtgaaaactg     1620

tgccaagcag gttttcacgg accctagcaa ccttcagcgg cacattcgct ctcagcatgt     1680

cggtgcccgg gcccatgcat gcccggagtg tggcaaaacg tttgccactt cgtcgggcct     1740

caaacaacac aagcacatcc acagcagtgt gaagcccttt atctgtgagg tctgccataa     1800

atcctatact cagttttcaa acctttgccg tcataagcgc atgcatgctg attgcagaac     1860

ccaaatcaag tgcaaagact gtggacaaat gttcagcact acgtcttcct taaataaaca     1920

caggaggttt tgtgagggca agaaccattt tgcggcaggt ggattttttg gccaaggcat     1980

ttcacttcct ggaaccccag ctatggataa aacgtccatg gttaatatga gtcatgccaa     2040

cccgggcctt gctgactatt ttggcgccaa taggcatcct gctggtctta cctttccaac     2100

agctcctgga ttttctttta gcttccctgg tctgtttcct tccggcttgt accacaggcc     2160

tcctttgata cctgctagtt ctcctgttaa aggactatca agtactgaac agacaaacaa     2220

aagtcaaagt cccctcatga cacatcctca gatactgcca gctacacagg atattttgaa     2280

ggcactatct aaacacccat ctgtagggga caataagcca gtggagctcc agcccgagag     2340

gtcctctgaa gagaggccct ttgagaaaat cagtgaccag tcagagagta gtgaccttga     2400

tgatgtcagt acaccaagtg gcagtgacct ggaaacaacc tcgggctctg atctggaaag     2460

tgacattgaa agtgataaag agaaatttaa agaaaatggt aaaatgttca aagacaaagt     2520

aagccctctt cagaatctgg cttcaataaa taataagaaa gaatacagca atcattccat     2580

tttctcacca tctttagagg agcagactgc ggtgtcagga gctgtgaatg attctataaa     2640

ggctattgct tctattgctg aaaaatactt tggttcaaca ggactggtgg ggctgcaaga     2700

caaaaaagtt ggagctttac cttacccttc catgtttccc ctcccatttt ttccagcatt     2760

ctctcaatca atgtacccat ttcctgatag agacttgaga tcgttacctt tgaaaatgga     2820

accccaatca ccaggtgaag taaagaaact gcagaagggc agctctgagt ccccctttga     2880

tctcaccact aagcgaaagg atgagaagcc cttgactcca gtcccctcca agcctccagt     2940

gacacctgcc acaagccaag accagcccct ggatctaagt atgggcagta ggagtagagc     3000

cagtgggaca aagctgactg agcctcgaaa aaaccacgtg tttgggggaa aaaaaggaag     3060

caacgtcgaa tcaagacctg cttcagatgg ttccttgcag catgcaagac ccactccttt     3120

ctttatggac cctatttaca gagtagagaa aagaaaacta actgacccac ttgaagcttt     3180

aaaagagaaa tacttgaggc cttctccagg attcttgttt cacccacaat tccaactgcc     3240

tgatcagaga acttggatgt cagctattga aaacatggca gaaaagctag agagcttcag     3300

tgccctgaaa cctgaggcca gtgagctctt acagtcagtg ccctctatgt tcaacttcag     3360

ggcgcctccc aatgccctgc cagagaacct tctgcggaag ggaaaggagc gctatacctg     3420

cagatactgt ggcaagattt ttccaaggtc tgcaaaccta acacggcact tgagaaccca     3480

cacaggagag cagccttaca gatgcaaata ctgtgacaga tcatttagca tatcttctaa     3540

cttgcaaagg catgttcgca acatccacaa taaagagaag ccatttaagt gtcacttatg     3600

tgataggtgt tttggtcaac aaaccaattt agacagacac ctaaagaaac atgagaatgg     3660

gaacatgtcc ggtacagcaa catcgtcgcc tcattctgaa ctggaaagta caggtgcgat     3720

tctggatgac aaagaagatg cttacttcac agaaattcga aatttcattg ggaacagcaa     3780

ccatggcagc caatctccca ggaatgtgga ggagagaatg aatggcagtc attttaaaga     3840

tgaaaaggct ttggtgacca gtcaaaattc agacttgctg gatgatgaag aagttgaaga     3900

tgaggtgttg ttagatgagg aggatgaaga caatgatatt actggaaaaa caggaaagga     3960

accagtgaca agtaatttac atgaaggaaa ccctgaggat gactatgaag aaaccagtgc     4020

cctggagatg agttgcaaga catccccagt gaggtataaa gaggaagaat ataaaagtgg     4080

actttctgct ctagatcata taaggcactt cacagatagc ctcaaaatga ggaaaatgga     4140

agataatcaa tattctgaag ctgagctgtc ttcttttagt acttcccatg tgccagagga     4200

acttaagcag ccgttacaca gaaagtccaa atcgcaggag gaaagtaaag cttaaaaggt     4260

taagcaactt gctcaagatc acacagctag gcatatgcta tgatgctgtc actgtctgac     4320

aaggagtccc tccattctac atcccacagt tcttccaacg tgtggcacag tatggccagg     4380

gctgcggcgg aatccagtgc tatccagtcc ataagccacg tatgacgtta tcaaggttga     4440

ccagagtggg accaagtcca acagtagcat ggctctttca tataggacta tttacaagac     4500

tgctgagcag aatgccttat aaacctgcag ggtcactcat ctaaagtcta gtgaccttaa     4560

actgaatgat ttaaaaaaga aaagaaagaa aaaagaaact atttattctc gatattttgt     4620

tttgcacagc aaaggcagct gctgacttct ggaagatcaa tcaatgcgac ttaaagtgat     4680

tcagtgaaaa caaaaaactt ggtgggctga aggcatcttc cagtttaccc caccttaggg     4740

tatgggtggg tgagaagggc agttgagatg gcagcattga tatgaatgaa cactccatag     4800

aaactgaatt ctcttttgta caagatcacc tgacatgatt gggaacagtt gcttttaatt     4860

acagatttaa tttttttctt cgttaaagtt ttatgtaatt taaccctttg aagacagaag     4920

tagttggatg aaatgcacag tcaattatta tagaaactga taacagggag tacttgttcc     4980

cccttttgcc ttcttaagta cattgtttaa aactagggaa aaagggtatg tgtatattgt     5040

aaactatgga tgttaacact caaagaggtt aagtcagtga agtaacctat tcatcaccag     5100

taccgctgta ccactaataa attgtttgcc aaatccttgt aataacatct taattttaga     5160

caatcatgtc actgttttta atgtttattt ttttgtgtgt gttgcgtgta tcatgtattt     5220

atttgttggc aaactattgt ttgttgatta aaatagcact gttccagtca gccactactt     5280

tatgacgtct gaggcacacc cctttccgaa tttcaaggac caaggtgacc cgacctgtgt     5340

atgagagtgc caaatggtgt ttggcttttc ttaacattcc tttttgtttg tttgttttgt     5400

tttccttctt aatgaactaa atacgaatag atgcaactta gtttttgtaa tactgaaatc     5460

gattcaattg tataaacgat tataatttct ttcatggaag catgattctt ctgattaaaa     5520

actgtactcc atattttatg ctggttgtct gcaagcttgt gcgatgttat gttcatgtta     5580

atcctatttg taaaatgaag tgttcccaac cttatgttaa aagagagaag taaataacag     5640

actgtattca gttattttgc cctttattga ggaaccagat ttgttttctt tttgtttgta     5700

atctcatttt gaaataatca gcaagttgag gtactttctt caaatgcttt gtacaatata     5760

aactgttatg cctttcagtg cattactatg ggaggagcaa ctaaaaaata aagacttaca     5820

aaaaggagta tttttcccca ctgtgtggta tttttccttc atgcaatttt actttccctt     5880

tgggatccaa tgatttaaag atatgat                                         5907


<210>  11
<211>  4900
<212>  DNA
<213>  Homo sapiens

<400>  11
ccttgccaag taacagcttt gctgtccaac atcgtgtgct gcttcgcgag aaagtcacat       60

tcggaccctt tggctagatt gcttattcat agggcttctt gactaaagcc cttggagcac      120

tgggtttttc ttgaagtata tgatcttaga cgaattttac aatgtgaagt tctgcataga      180

tgccagtcaa ccagatgttg gaagctggct caagtacatt agattcgctg gctgttatga      240

tcagcacaac cttgttgcat gccagataaa tgatcagata ttctatagag tagttgcaga      300

cattgcgccg ggagaggagc ttctgctgtt catgaagagc gaagactatc cccatgaaac      360

tatggcgccg gatatccacg aagaacggca atatcgctgc gaagactgtg accagctctt      420

tgaatctaag gctgaactag cagatcacca aaagtttcca tgcagtactc ctcactcagc      480

attttcaatg gttgaagagg actttcagca aaaactcgaa agcgagaatg atctccaaga      540

gatacacacg atccaggagt gtaaggaatg tgaccaagtt tttcctgatt tgcaaagcct      600

ggagaaacac atgctgtcac atactgaaga gagggaatac aagtgtgatc agtgtcccaa      660

ggcatttaac tggaagtcca atttaattcg ccaccagatg tcacatgaca gtggaaagca      720

ctatgaatgt gaaaactgtg ccaagcaggt tttcacggac cctagcaacc ttcagcggca      780

cattcgctct cagcatgtcg gtgcccgggc ccatgcatgc ccggagtgtg gcaaaacgtt      840

tgccacttcg tcgggcctca aacaacacaa gcacatccac agcagtgtga agccctttat      900

ctgtgaggtc tgccataaat cctatactca gttttcaaac ctttgccgtc ataagcgcat      960

gcatgctgat tgcagaaccc aaatcaagtg caaagactgt ggacaaatgt tcagcactac     1020

gtcttcctta aataaacaca ggaggttttg tgagggcaag aaccattttg cggcaggtgg     1080

attttttggc caaggcattt cacttcctgg aaccccagct atggataaaa cgtccatggt     1140

taatatgagt catgccaacc cgggccttgc tgactatttt ggcgccaata ggcatcctgc     1200

tggtcttacc tttccaacag ctcctggatt ttcttttagc ttccctggtc tgtttccttc     1260

cggcttgtac cacaggcctc ctttgatacc tgctagttct cctgttaaag gactatcaag     1320

tactgaacag acaaacaaaa gtcaaagtcc cctcatgaca catcctcaga tactgccagc     1380

tacacaggat attttgaagg cactatctaa acacccatct gtaggggaca ataagccagt     1440

ggagctccag cccgagaggt cctctgaaga gaggcccttt gagaaaatca gtgaccagtc     1500

agagagtagt gaccttgatg atgtcagtac accaagtggc agtgacctgg aaacaacctc     1560

gggctctgat ctggaaagtg acattgaaag tgataaagag aaatttaaag aaaatggtaa     1620

aatgttcaaa gacaaagtaa gccctcttca gaatctggct tcaataaata ataagaaaga     1680

atacagcaat cattccattt tctcaccatc tttagaggag cagactgcgg tgtcaggagc     1740

tgtgaatgat tctataaagg ctattgcttc tattgctgaa aaatactttg gttcaacagg     1800

actggtgggg ctgcaagaca aaaaagttgg agctttacct tacccttcca tgtttcccct     1860

cccatttttt ccagcattct ctcaatcaat gtacccattt cctgatagag acttgagatc     1920

gttacctttg aaaatggaac cccaatcacc aggtgaagta aagaaactgc agaagggcag     1980

ctctgagtcc ccctttgatc tcaccactaa gcgaaaggat gagaagccct tgactccagt     2040

cccctccaag cctccagtga cacctgccac aagccaagac cagcccctgg atctaagtat     2100

gggcagtagg agtagagcca gtgggacaaa gctgactgag cctcgaaaaa accacgtgtt     2160

tgggggaaaa aaaggaagca acgtcgaatc aagacctgct tcagatggtt ccttgcagca     2220

tgcaagaccc actcctttct ttatggaccc tatttacaga gtagagaaaa gaaaactaac     2280

tgacccactt gaagctttaa aagagaaata cttgaggcct tctccaggat tcttgtttca     2340

cccacaattc caactgcctg atcagagaac ttggatgtca gctattgaaa acatggcaga     2400

aaagctagag agcttcagtg ccctgaaacc tgaggccagt gagctcttac agtcagtgcc     2460

ctctatgttc aacttcaggg cgcctcccaa tgccctgcca gagaaccttc tgcggaaggg     2520

aaaggagcgc tatacctgca gatactgtgg caagattttt ccaaggtctg caaacctaac     2580

acggcacttg agaacccaca caggagagca gccttacaga tgcaaatact gtgacagatc     2640

atttagcata tcttctaact tgcaaaggca tgttcgcaac atccacaata aagagaagcc     2700

atttaagtgt cacttatgtg ataggtgttt tggtcaacaa accaatttag acagacacct     2760

aaagaaacat gagaatggga acatgtccgg tacagcaaca tcgtcgcctc attctgaact     2820

ggaaagtaca ggtgcgattc tggatgacaa agaagatgct tacttcacag aaattcgaaa     2880

tttcattggg aacagcaacc atggcagcca atctcccagg aatgtggagg agagaatgaa     2940

tggcagtcat tttaaagatg aaaaggcttt ggtgaccagt caaaattcag acttgctgga     3000

tgatgaagaa gttgaagatg aggtgttgtt agatgaggag gatgaagaca atgatattac     3060

tggaaaaaca ggaaaggaac cagtgacaag taatttacat gaaggaaacc ctgaggatga     3120

ctatgaagaa accagtgccc tggagatgag ttgcaagaca tccccagtga ggtataaaga     3180

ggaagaatat aaaagtggac tttctgctct agatcatata aggcacttca cagatagcct     3240

caaaatgagg aaaatggaag ataatcaata ttctgaagct gagctgtctt cttttagtac     3300

ttcccatgtg ccagaggaac ttaagcagcc gttacacaga aagtccaaat cgcaggcata     3360

tgctatgatg ctgtcactgt ctgacaagga gtccctccat tctacatccc acagttcttc     3420

caacgtgtgg cacagtatgg ccagggctgc ggcggaatcc agtgctatcc agtccataag     3480

ccacgtatga cgttatcaag gttgaccaga gtgggaccaa gtccaacagt agcatggctc     3540

tttcatatag gactatttac aagactgctg agcagaatgc cttataaacc tgcagggtca     3600

ctcatctaaa gtctagtgac cttaaactga atgatttaaa aaagaaaaga aagaaaaaag     3660

aaactattta ttctcgatat tttgttttgc acagcaaagg cagctgctga cttctggaag     3720

atcaatcaat gcgacttaaa gtgattcagt gaaaacaaaa aacttggtgg gctgaaggca     3780

tcttccagtt taccccacct tagggtatgg gtgggtgaga agggcagttg agatggcagc     3840

attgatatga atgaacactc catagaaact gaattctctt ttgtacaaga tcacctgaca     3900

tgattgggaa cagttgcttt taattacaga tttaattttt ttcttcgtta aagttttatg     3960

taatttaacc ctttgaagac agaagtagtt ggatgaaatg cacagtcaat tattatagaa     4020

actgataaca gggagtactt gttccccctt ttgccttctt aagtacattg tttaaaacta     4080

gggaaaaagg gtatgtgtat attgtaaact atggatgtta acactcaaag aggttaagtc     4140

agtgaagtaa cctattcatc accagtaccg ctgtaccact aataaattgt ttgccaaatc     4200

cttgtaataa catcttaatt ttagacaatc atgtcactgt ttttaatgtt tatttttttg     4260

tgtgtgttgc gtgtatcatg tatttatttg ttggcaaact attgtttgtt gattaaaata     4320

gcactgttcc agtcagccac tactttatga cgtctgaggc acaccccttt ccgaatttca     4380

aggaccaagg tgacccgacc tgtgtatgag agtgccaaat ggtgtttggc ttttcttaac     4440

attccttttt gtttgtttgt tttgttttcc ttcttaatga actaaatacg aatagatgca     4500

acttagtttt tgtaatactg aaatcgattc aattgtataa acgattataa tttctttcat     4560

ggaagcatga ttcttctgat taaaaactgt actccatatt ttatgctggt tgtctgcaag     4620

cttgtgcgat gttatgttca tgttaatcct atttgtaaaa tgaagtgttc ccaaccttat     4680

gttaaaagag agaagtaaat aacagactgt attcagttat tttgcccttt attgaggaac     4740

cagatttgtt ttctttttgt ttgtaatctc attttgaaat aatcagcaag ttgaggtact     4800

ttcttcaaat gctttgtaca atataaactg ttatgccttt cagtgcatta ctatgggagg     4860

agcaactaaa aaataaagac ttacaaaaag gagtattttt                           4900


<210>  12
<211>  4835
<212>  DNA
<213>  Homo sapiens

<400>  12
ccttgccaag taacagcttt gctgtccaac atcgtgtgct gcttcgcgag aaagtcacat       60

tcggaccctt tggctagatt atcttagacg aattttacaa tgtgaagttc tgcatagatg      120

ccagtcaacc agatgttgga agctggctca agtacattag attcgctggc tgttatgatc      180

agcacaacct tgttgcatgc cagataaatg atcagatatt ctatagagta gttgcagaca      240

ttgcgccggg agaggagctt ctgctgttca tgaagagcga agactatccc catgaaacta      300

tggcgccgga tatccacgaa gaacggcaat atcgctgcga agactgtgac cagctctttg      360

aatctaaggc tgaactagca gatcaccaaa agtttccatg cagtactcct cactcagcat      420

tttcaatggt tgaagaggac tttcagcaaa aactcgaaag cgagaatgat ctccaagaga      480

tacacacgat ccaggagtgt aaggaatgtg accaagtttt tcctgatttg caaagcctgg      540

agaaacacat gctgtcacat actgaagaga gggaatacaa gtgtgatcag tgtcccaagg      600

catttaactg gaagtccaat ttaattcgcc accagatgtc acatgacagt ggaaagcact      660

atgaatgtga aaactgtgcc aaggttttca cggaccctag caaccttcag cggcacattc      720

gctctcagca tgtcggtgcc cgggcccatg catgcccgga gtgtggcaaa acgtttgcca      780

cttcgtcggg cctcaaacaa cacaagcaca tccacagcag tgtgaagccc tttatctgtg      840

aggtctgcca taaatcctat actcagtttt caaacctttg ccgtcataag cgcatgcatg      900

ctgattgcag aacccaaatc aagtgcaaag actgtggaca aatgttcagc actacgtctt      960

ccttaaataa acacaggagg ttttgtgagg gcaagaacca ttttgcggca ggtggatttt     1020

ttggccaagg catttcactt cctggaaccc cagctatgga taaaacgtcc atggttaata     1080

tgagtcatgc caacccgggc cttgctgact attttggcgc caataggcat cctgctggtc     1140

ttacctttcc aacagctcct ggattttctt ttagcttccc tggtctgttt ccttccggct     1200

tgtaccacag gcctcctttg atacctgcta gttctcctgt taaaggacta tcaagtactg     1260

aacagacaaa caaaagtcaa agtcccctca tgacacatcc tcagatactg ccagctacac     1320

aggatatttt gaaggcacta tctaaacacc catctgtagg ggacaataag ccagtggagc     1380

tccagcccga gaggtcctct gaagagaggc cctttgagaa aatcagtgac cagtcagaga     1440

gtagtgacct tgatgatgtc agtacaccaa gtggcagtga cctggaaaca acctcgggct     1500

ctgatctgga aagtgacatt gaaagtgata aagagaaatt taaagaaaat ggtaaaatgt     1560

tcaaagacaa agtaagccct cttcagaatc tggcttcaat aaataataag aaagaataca     1620

gcaatcattc cattttctca ccatctttag aggagcagac tgcggtgtca ggagctgtga     1680

atgattctat aaaggctatt gcttctattg ctgaaaaata ctttggttca acaggactgg     1740

tggggctgca agacaaaaaa gttggagctt taccttaccc ttccatgttt cccctcccat     1800

tttttccagc attctctcaa tcaatgtacc catttcctga tagagacttg agatcgttac     1860

ctttgaaaat ggaaccccaa tcaccaggtg aagtaaagaa actgcagaag ggcagctctg     1920

agtccccctt tgatctcacc actaagcgaa aggatgagaa gcccttgact ccagtcccct     1980

ccaagcctcc agtgacacct gccacaagcc aagaccagcc cctggatcta agtatgggca     2040

gtaggagtag agccagtggg acaaagctga ctgagcctcg aaaaaaccac gtgtttgggg     2100

gaaaaaaagg aagcaacgtc gaatcaagac ctgcttcaga tggttccttg cagcatgcaa     2160

gacccactcc tttctttatg gaccctattt acagagtaga gaaaagaaaa ctaactgacc     2220

cacttgaagc tttaaaagag aaatacttga ggccttctcc aggattcttg tttcacccac     2280

aattccaact gcctgatcag agaacttgga tgtcagctat tgaaaacatg gcagaaaagc     2340

tagagagctt cagtgccctg aaacctgagg ccagtgagct cttacagtca gtgccctcta     2400

tgttcaactt cagggcgcct cccaatgccc tgccagagaa ccttctgcgg aagggaaagg     2460

agcgctatac ctgcagatac tgtggcaaga tttttccaag gtctgcaaac ctaacacggc     2520

acttgagaac ccacacagga gagcagcctt acagatgcaa atactgtgac agatcattta     2580

gcatatcttc taacttgcaa aggcatgttc gcaacatcca caataaagag aagccattta     2640

agtgtcactt atgtgatagg tgttttggtc aacaaaccaa tttagacaga cacctaaaga     2700

aacatgagaa tgggaacatg tccggtacag caacatcgtc gcctcattct gaactggaaa     2760

gtacaggtgc gattctggat gacaaagaag atgcttactt cacagaaatt cgaaatttca     2820

ttgggaacag caaccatggc agccaatctc ccaggaatgt ggaggagaga atgaatggca     2880

gtcattttaa agatgaaaag gctttggtga ccagtcaaaa ttcagacttg ctggatgatg     2940

aagaagttga agatgaggtg ttgttagatg aggaggatga agacaatgat attactggaa     3000

aaacaggaaa ggaaccagtg acaagtaatt tacatgaagg aaaccctgag gatgactatg     3060

aagaaaccag tgccctggag atgagttgca agacatcccc agtgaggtat aaagaggaag     3120

aatataaaag tggactttct gctctagatc atataaggca cttcacagat agcctcaaaa     3180

tgaggaaaat ggaagataat caatattctg aagctgagct gtcttctttt agtacttccc     3240

atgtgccaga ggaacttaag cagccgttac acagaaagtc caaatcgcag gcatatgcta     3300

tgatgctgtc actgtctgac aaggagtccc tccattctac atcccacagt tcttccaacg     3360

tgtggcacag tatggccagg gctgcggcgg aatccagtgc tatccagtcc ataagccacg     3420

tatgacgtta tcaaggttga ccagagtggg accaagtcca acagtagcat ggctctttca     3480

tataggacta tttacaagac tgctgagcag aatgccttat aaacctgcag ggtcactcat     3540

ctaaagtcta gtgaccttaa actgaatgat ttaaaaaaga aaagaaagaa aaaagaaact     3600

atttattctc gatattttgt tttgcacagc aaaggcagct gctgacttct ggaagatcaa     3660

tcaatgcgac ttaaagtgat tcagtgaaaa caaaaaactt ggtgggctga aggcatcttc     3720

cagtttaccc caccttaggg tatgggtggg tgagaagggc agttgagatg gcagcattga     3780

tatgaatgaa cactccatag aaactgaatt ctcttttgta caagatcacc tgacatgatt     3840

gggaacagtt gcttttaatt acagatttaa tttttttctt cgttaaagtt ttatgtaatt     3900

taaccctttg aagacagaag tagttggatg aaatgcacag tcaattatta tagaaactga     3960

taacagggag tacttgttcc cccttttgcc ttcttaagta cattgtttaa aactagggaa     4020

aaagggtatg tgtatattgt aaactatgga tgttaacact caaagaggtt aagtcagtga     4080

agtaacctat tcatcaccag taccgctgta ccactaataa attgtttgcc aaatccttgt     4140

aataacatct taattttaga caatcatgtc actgttttta atgtttattt ttttgtgtgt     4200

gttgcgtgta tcatgtattt atttgttggc aaactattgt ttgttgatta aaatagcact     4260

gttccagtca gccactactt tatgacgtct gaggcacacc cctttccgaa tttcaaggac     4320

caaggtgacc cgacctgtgt atgagagtgc caaatggtgt ttggcttttc ttaacattcc     4380

tttttgtttg tttgttttgt tttccttctt aatgaactaa atacgaatag atgcaactta     4440

gtttttgtaa tactgaaatc gattcaattg tataaacgat tataatttct ttcatggaag     4500

catgattctt ctgattaaaa actgtactcc atattttatg ctggttgtct gcaagcttgt     4560

gcgatgttat gttcatgtta atcctatttg taaaatgaag tgttcccaac cttatgttaa     4620

aagagagaag taaataacag actgtattca gttattttgc cctttattga ggaaccagat     4680

ttgttttctt tttgtttgta atctcatttt gaaataatca gcaagttgag gtactttctt     4740

caaatgcttt gtacaatata aactgttatg cctttcagtg cattactatg ggaggagcaa     4800

ctaaaaaata aagacttaca aaaaggagta ttttt                                4835


<210>  13
<211>  5732
<212>  DNA
<213>  Homo sapiens

<400>  13
cacacacaca cacacacacc acacttgtgc tttcaagaca tcgaaacgga ggctatttcc       60

ctggggaaag aaatcctgcc tggcgagatc tccccattgg ttgtttaccc ggagaaatct      120

acatgtttaa gggggatggt gcatccataa tcagtctgtc cctataggac ttgggtcttg      180

gcgacctttt tgtgacctct cccgccagag gaggctgctg tcactttaaa aatttaaaag      240

aggagcccgt ctggcttccg atcagatcac tctgggcggc gggagatagc tccctttctc      300

cctcgccccg ggttctttct ggatggccga gcagatcctc tttaaagaga cagttcatga      360

aatagaaacc cggcggctga gcttggagtt gcgaaagggg acgatcccgt gagggtccag      420

gacccgcgaa ggcgctgcgg aggatctgaa agggggatag agctcccctc gcctccccag      480

gccccccacc ttttcaaact ctcctcctcc tgcttgtttt cccccattgg aactgggaag      540

gagaagtaga agttttagtg ggtttcagat aactttcatt acacatcggg ctgataagag      600

caagagaaag tgagaaaaga gggaggtgat gtgaaccaga aggaatagct ccgagctcat      660

ttaggaaggg ggaaaaagcc aaaacacacc aaacccgggt cacccagacg aaagaagact      720

tcatttcttg tattaaaaat acactgttgg cggacaataa atccgaaacg cgtggtcctg      780

gagagcagat cctagagacg gacaaagttg tcagagaccc atttggaaat cgagacgcga      840

ggcttttaaa aaattattat tattattttt aaacatctct aaatgttgct cgggatcgtt      900

tgaaaggatt ttcgtgcagg agcgttgggg gctgctgatt attttatttt gtttattttg      960

attcttctgt gaatgcctat tattgctgag ttgaggccat agaaatctaa agatcttaga     1020

cgaattttac aatgtgaagt tctgcataga tgccagtcaa ccagatgttg gaagctggct     1080

caagtacatt agattcgctg gctgttatga tcagcacaac cttgttgcat gccagataaa     1140

tgatcagata ttctatagag tagttgcaga cattgcgccg ggagaggagc ttctgctgtt     1200

catgaagagc gaagactatc cccatgaaac tatggcgccg gatatccacg aagaacggca     1260

atatcgctgc gaagactgtg accagctctt tgaatctaag gctgaactag cagatcacca     1320

aaagtttcca tgcagtactc ctcactcagc attttcaatg gttgaagagg actttcagca     1380

aaaactcgaa agcgagaatg atctccaaga gatacacacg atccaggagt gtaaggaatg     1440

tgaccaagtt tttcctgatt tgcaaagcct ggagaaacac atgctgtcac atactgaaga     1500

gagggaatac aagtgtgatc agtgtcccaa ggcatttaac tggaagtcca atttaattcg     1560

ccaccagatg tcacatgaca gtggaaagca ctatgaatgt gaaaactgtg ccaaggtttt     1620

cacggaccct agcaaccttc agcggcacat tcgctctcag catgtcggtg cccgggccca     1680

tgcatgcccg gagtgtggca aaacgtttgc cacttcgtcg ggcctcaaac aacacaagca     1740

catccacagc agtgtgaagc cctttatctg tgaggtctgc cataaatcct atactcagtt     1800

ttcaaacctt tgccgtcata agcgcatgca tgctgattgc agaacccaaa tcaagtgcaa     1860

agactgtgga caaatgttca gcactacgtc ttccttaaat aaacacagga ggttttgtga     1920

gggcaagaac cattttgcgg caggtggatt ttttggccaa ggcatttcac ttcctggaac     1980

cccagctatg gataaaacgt ccatggttaa tatgagtcat gccaacccgg gccttgctga     2040

ctattttggc gccaataggc atcctgctgg tcttaccttt ccaacagctc ctggattttc     2100

ttttagcttc cctggtctgt ttccttccgg cttgtaccac aggcctcctt tgatacctgc     2160

tagttctcct gttaaaggac tatcaagtac tgaacagaca aacaaaagtc aaagtcccct     2220

catgacacat cctcagatac tgccagctac acaggatatt ttgaaggcac tatctaaaca     2280

cccatctgta ggggacaata agccagtgga gctccagccc gagaggtcct ctgaagagag     2340

gccctttgag aaaatcagtg accagtcaga gagtagtgac cttgatgatg tcagtacacc     2400

aagtggcagt gacctggaaa caacctcggg ctctgatctg gaaagtgaca ttgaaagtga     2460

taaagagaaa tttaaagaaa atggtaaaat gttcaaagac aaagtaagcc ctcttcagaa     2520

tctggcttca ataaataata agaaagaata cagcaatcat tccattttct caccatcttt     2580

agaggagcag actgcggtgt caggagctgt gaatgattct ataaaggcta ttgcttctat     2640

tgctgaaaaa tactttggtt caacaggact ggtggggctg caagacaaaa aagttggagc     2700

tttaccttac ccttccatgt ttcccctccc attttttcca gcattctctc aatcaatgta     2760

cccatttcct gatagagact tgagatcgtt acctttgaaa atggaacccc aatcaccagg     2820

tgaagtaaag aaactgcaga agggcagctc tgagtccccc tttgatctca ccactaagcg     2880

aaaggatgag aagcccttga ctccagtccc ctccaagcct ccagtgacac ctgccacaag     2940

ccaagaccag cccctggatc taagtatggg cagtaggagt agagccagtg ggacaaagct     3000

gactgagcct cgaaaaaacc acgtgtttgg gggaaaaaaa ggaagcaacg tcgaatcaag     3060

acctgcttca gatggttcct tgcagcatgc aagacccact cctttcttta tggaccctat     3120

ttacagagta gagaaaagaa aactaactga cccacttgaa gctttaaaag agaaatactt     3180

gaggccttct ccaggattct tgtttcaccc acaaatgtca gctattgaaa acatggcaga     3240

aaagctagag agcttcagtg ccctgaaacc tgaggccagt gagctcttac agtcagtgcc     3300

ctctatgttc aacttcaggg cgcctcccaa tgccctgcca gagaaccttc tgcggaaggg     3360

aaaggagcgc tatacctgca gatactgtgg caagattttt ccaaggtctg caaacctaac     3420

acggcacttg agaacccaca caggagagca gccttacaga tgcaaatact gtgacagatc     3480

atttagcata tcttctaact tgcaaaggca tgttcgcaac atccacaata aagagaagcc     3540

atttaagtgt cacttatgtg ataggtgttt tggtcaacaa accaatttag acagacacct     3600

aaagaaacat gagaatggga acatgtccgg tacagcaaca tcgtcgcctc attctgaact     3660

ggaaagtaca ggtgcgattc tggatgacaa agaagatgct tacttcacag aaattcgaaa     3720

tttcattggg aacagcaacc atggcagcca atctcccagg aatgtggagg agagaatgaa     3780

tggcagtcat tttaaagatg aaaaggcttt ggtgaccagt caaaattcag acttgctgga     3840

tgatgaagaa gttgaagatg aggtgttgtt agatgaggag gatgaagaca atgatattac     3900

tggaaaaaca ggaaaggaac cagtgacaag taatttacat gaaggaaacc ctgaggatga     3960

ctatgaagaa accagtgccc tggagatgag ttgcaagaca tccccagtga ggtataaaga     4020

ggaagaatat aaaagtggac tttctgctct agatcatata aggcacttca cagatagcct     4080

caaaatgagg aaaatggaag ataatcaata ttctgaagct gagctgtctt cttttagtac     4140

ttcccatgtg ccagaggaac ttaagcagcc gttacacaga aagtccaaat cgcaggcata     4200

tgctatgatg ctgtcactgt ctgacaagga gtccctccat tctacatccc acagttcttc     4260

caacgtgtgg cacagtatgg ccagggctgc ggcggaatcc agtgctatcc agtccataag     4320

ccacgtatga cgttatcaag gttgaccaga gtgggaccaa gtccaacagt agcatggctc     4380

tttcatatag gactatttac aagactgctg agcagaatgc cttataaacc tgcagggtca     4440

ctcatctaaa gtctagtgac cttaaactga atgatttaaa aaagaaaaga aagaaaaaag     4500

aaactattta ttctcgatat tttgttttgc acagcaaagg cagctgctga cttctggaag     4560

atcaatcaat gcgacttaaa gtgattcagt gaaaacaaaa aacttggtgg gctgaaggca     4620

tcttccagtt taccccacct tagggtatgg gtgggtgaga agggcagttg agatggcagc     4680

attgatatga atgaacactc catagaaact gaattctctt ttgtacaaga tcacctgaca     4740

tgattgggaa cagttgcttt taattacaga tttaattttt ttcttcgtta aagttttatg     4800

taatttaacc ctttgaagac agaagtagtt ggatgaaatg cacagtcaat tattatagaa     4860

actgataaca gggagtactt gttccccctt ttgccttctt aagtacattg tttaaaacta     4920

gggaaaaagg gtatgtgtat attgtaaact atggatgtta acactcaaag aggttaagtc     4980

agtgaagtaa cctattcatc accagtaccg ctgtaccact aataaattgt ttgccaaatc     5040

cttgtaataa catcttaatt ttagacaatc atgtcactgt ttttaatgtt tatttttttg     5100

tgtgtgttgc gtgtatcatg tatttatttg ttggcaaact attgtttgtt gattaaaata     5160

gcactgttcc agtcagccac tactttatga cgtctgaggc acaccccttt ccgaatttca     5220

aggaccaagg tgacccgacc tgtgtatgag agtgccaaat ggtgtttggc ttttcttaac     5280

attccttttt gtttgtttgt tttgttttcc ttcttaatga actaaatacg aatagatgca     5340

acttagtttt tgtaatactg aaatcgattc aattgtataa acgattataa tttctttcat     5400

ggaagcatga ttcttctgat taaaaactgt actccatatt ttatgctggt tgtctgcaag     5460

cttgtgcgat gttatgttca tgttaatcct atttgtaaaa tgaagtgttc ccaaccttat     5520

gttaaaagag agaagtaaat aacagactgt attcagttat tttgcccttt attgaggaac     5580

cagatttgtt ttctttttgt ttgtaatctc attttgaaat aatcagcaag ttgaggtact     5640

ttcttcaaat gctttgtaca atataaactg ttatgccttt cagtgcatta ctatgggagg     5700

agcaactaaa aaataaagac ttacaaaaag ga                                   5732


<210>  14
<211>  965
<212>  DNA
<213>  Homo sapiens

<400>  14
tgtgaccagc tctttgaatc taaggctgaa ctagcagatc accaaaagtt tccatgcagt       60

actcctcact cagcattttc aatggttgaa gaggactttc agcaaaaact cgaaagcgag      120

aatgatctcc aagagataca cacgatccag gagtgtaagg aatgtgacca agtttttcct      180

gatttgcaaa gcctggagaa acacatgctg tcacatactg aagagaggga atacaagtgt      240

gatcagtgtc ccaaggcatt taactggaag tccaatttaa ttcgccacca gatgtcacat      300

gacagtggaa agcactatga atgtgaaaac tgtgccaagg ttttcacgga ccctagcaac      360

cttcagcggc acattcgctc tcagcatgtc ggtgcccggg cccatgcatg cccggagtgt      420

ggcaaaacgt ttgccacttc gtcgggcctc aaacaacaca agcacatcca cagcagtgtg      480

aagcccttta tctcattctc tcaatcaatg tacccatttc ctgatagaga cttgagatcg      540

ttacctttga aaatggaacc ccaatcacca ggtgaagtaa agaaactgca gaagggcagc      600

tctgagtccc cctttgatct caccactaag cgaaaggatg agaagccctt gactccagtc      660

ccctccaagc ctccagtgac acctgccaca agccaagacc agcccctgga tctaagtatg      720

ggcagtagga gtagagccag tgggacaaag ctgactgagc ctcgaaaaaa ccacgtgttt      780

gggggaaaaa aaggaagcaa cgtcgaatca agacctgctt cagatggttc cttgcagcat      840

gcaagaccca ctcctttctt tatggaccct atttacagag tagagaaaag aaaactaact      900

gacccacttg aagctttaaa agagaaatac ttgaggcctt ctccaggatt cttgtttcac      960

ccaca                                                                  965


<210>  15
<211>  418
<212>  DNA
<213>  Homo sapiens

<400>  15
tgtcccaagg catttaactg gaagtccaat ttaattcgcc accagatgtc acatgacagt       60

ggaaagcact atgaatgtga aaactgtgcc aagcaggttt tcacggaccc tagcaacctt      120

cagcggcaca ttcgctctca gcatgtcggt gcccgggccc atgcatgccc ggagtgtggc      180

aaaacgtttg ccacttcgtc gggcctcaaa caacacaagc acatccacag cagtgtgaag      240

ccctttatct gtaagttttc aacactccag ccctccttcc cacatctgtc tcttccccaa      300

aaggcactgt gaccaggaga gtggctgcac atggccttta gagggtcacc gtgttagcta      360

tttatggtcc aatccagtag ggctatttat gattacaagt aaatctttta taatcaga        418


<210>  16
<211>  2389
<212>  DNA
<213>  Homo sapiens

<400>  16
aaagagatag aatcaaactg ctttttttcg acatactggt ttttctttct gtttttcttc       60

tctttcttct atttcttgtg gatattatgg ctaataacac aacaagttta gggagtccat      120

ggccagaaaa cttttgggag gaccttatca tgtccttcac tgtatccatg gcaatcgggc      180

tggtacttgg aggatttatt tgggctgtgt tcatttgtct gtctcgaaga agaagagcca      240

gtgctcccat ctcacagtgg agttcaagca ggagatctag gtcttcttac acccacggcc      300

tcaacagaac tggattttac cgccacagtg gctgtgaacg tcgaagcaac ctcagcctgg      360

ccagtctcac cttccagcga caagcttccc tggaacaagc aaattccttt ccaagaaaat      420

caagtttcag agcttctact ttccatccct ttctgcaatg tccaccactt cctgtggaaa      480

ctgagagtca gctggtgact ctcccttctt ccaatatctc tcccaccatc agcacttccc      540

acagtctgag ccgtcctgac tactggtcca gtaacagtct tcgagtgggc ctttcaacac      600

cgcccccacc tgcctatgag tccatcatca aggcattccc agattcctga ggtcttgatc      660

cgtcgcccag gcgggagttg cagtagcatg atcaggactc actgcagcct ctatctccca      720

ggctcaagta atcctcccat cttagtgccc caagtagctg ggactacagg ggtgcactac      780

cacaccgggt tgaatttttt tttaatttta gtagagatga agtgtcacta tgttaccaag      840

gctggtctca aactcctaaa ctcagatgat cctcctgcct cggcctccca aagtgctgga      900

attagcctgg ccaatcttgg atttttaatg gaatatgtgg gcacaaaatg acagaacata      960

ggacattcta aagttccttg atttgatcat tataagaagt gtgggactca agcacaggaa     1020

actgaactct tttggtgtca ttggatgttt catttttgac actaattttt tctggacaaa     1080

ctctttatgt gtttttccca agaatagtta tctacttcct ggaggcaaaa tccttggatt     1140

tactaacatg atgatttacc ttttcttcac cgttgtcgtt acattgttag aaaagcaaca     1200

ggaaaaaatc caattcattt gacctaaaaa caagcctcaa gtttaaaacc aagctcacgt     1260

ttttcttaag ggaaaaattt tctttcttaa acttacatct agcaacttgg aaagcacttt     1320

ctctggggat cttcttttgt aactttgcag acaaataagt atgagtcact ggggagagag     1380

tttgttattg aaatagatgt tgcccatgaa gaattctcct tcctggattg actcttaatc     1440

atcaggcatc attcctggtt tgcttctcta cgaatctcaa ttccaacttc tctgcagagt     1500

ctgtacagtg attaagccat gccagatggt ctttggtgca cacagttatt taagaatcca     1560

cttccacagg tggctgccct tgtaaggaag aatgcatccc taaatgtggc caccagagag     1620

ttccagtggg cagatgtctg tggctgccct tctcatttaa ggacatgagt tcactggagt     1680

attactcaaa aagtctgtgg ttcatttcca gtattgtgaa tatttagttt atgtggccgt     1740

ttctttgttt ctttgaacag tgggattttc agtgaaaaag taccctcttt ttcatttcct     1800

attgcagtgg tcacagctaa tagtgtctga acatggttca agaataagag attccatgta     1860

gcattttctt tattattttc atttccctta tattatccat cattccttaa ggacaattat     1920

tcttaataat gcttatagaa aatgttctct aattaaacat gccaaaagga aaaagtaaga     1980

gaaagaggga gcaagaagaa aatggaagaa aaagggaaaa aagctaaccg gataaccaat     2040

ttgttataag ttggttttca acaaagaaat ttagcagcca agtaaggttt caagggaata     2100

ttaacttggt atcagggcta cttttttttt ttttttttta cttgcatgtc atccttaatg     2160

tctaacatga aaaatcagca aagagtatgg tttttatcaa gaatttgtgt tgggagtaaa     2220

aactgcttta tagctcccaa attaggaaga gaagagcaga aatcctctgg ggcatttaac     2280

catctggcag aattgttgct gcacccttat cccagttata agacagtcaa aatgactatt     2340

tcctaaatat tgtgagtgta tgaaatgtga aattaaagca aaaactgga                 2389


<210>  17
<211>  10032
<212>  DNA
<213>  Homo sapiens

<400>  17
atctccgccg ccacctcggt ctcgctgctc ctgggcgggg ggtgaggacg agtccggagt       60

atctggggtt tggcgttgtt gtcagcctcg gggagagaga ttggacaaat attctccaag      120

aggaggaggg cgacgccaag gactttccac atcaactgct ttggggtatc tccacaagtt      180

ggaagaggga ccctttcgtt ttgcattgcg tgtgttgtgc tcattaccag tgcagcgact      240

gccgtcccag ggtgactctg agttgtcctt tatcgtgagc tagcaatggc tagcgaagac      300

aatcgtgtcc cttccccgcc accaacaggt gatgacgggg gaggtggagg gagagaagaa      360

acccctactg aagggggtgc attgtctctg aaaccagggc tccccatcag gggcatcaga      420

atgaaatttg ccgtgttgac cggtttggtt gaagttggag aagtatccaa tagggatatt      480

gtagaaactg tctttaacct gttggtagga ggacagtttg atctggaaat gaatttcatt      540

atccaagaag gtgagagtat taactgcatg gtggacctac tggaaaaatg tgacattacg      600

tgccaagcag aagtctggag catgtttaca gccattctga agaaaagcat acggaatctt      660

caagtctgca ctgaagtagg ccttgttgaa aaagtgcttg ggaaaattga aaaagttgac      720

aatatgatag cagatctttt ggttgacatg ttgggagtgc tggctagcta taatttgaca      780

gttcgcgagc taaagctttt cttcagtaaa cttcaaggag ataaaggacg atggcctcca      840

catgctggga agttgctgtc tgtgttaaag catatgcctc agaagtatgg tcctgatgcc      900

ttttttaact ttccaggaaa gagtgctgca gctattgcat tacctcctat agccaaatgg      960

ccataccaga atggttttac atttcataca tggcttagaa tggatcctgt aaataacatc     1020

aatgtagata aggataaacc atatttgtat tgtttcagaa ccagcaaagg tcttggctat     1080

tctgctcatt ttgttggagg ctgtttgatt gtaacatcaa taaagtcaaa aggaaaaggc     1140

tttcaacact gtgtgaaatt tgatttcaag ccacaaaagt ggtatatggt taccatagta     1200

cacatctata accgatggaa gaatagtgaa cttcgatgtt atgtgaatgg tgagctggct     1260

tcctatggag agataacatg gtttgtcaac actagcgata cctttgacaa atgtttcctg     1320

ggctcatcag aaacagcaga tgctaataga gtattctgtg gtcagatgac tgcagtttac     1380

cttttcagtg aagctctaaa tgcagctcag atatttgcta tttatcagtt gggcctggga     1440

tacaagggta catttaaatt caaagcagaa agcgaccttt tccttgctga gcatcacaaa     1500

cttttattgt acgatgggaa actctctagt gccattgcat tcacgtacaa tccacgggct     1560

acagatgccc agctttgtct tgaatcatct cctaaggaca acccttcaat ttttgttcat     1620

tcaccacatg cactcatgct ccaggatgta aaggcagttt taacacattc catccaaagt     1680

gcaatgcatt caattggagg agtacaagta ctatttccac tttttgcaca gttggattac     1740

aggcaatatt tgtctgatga gattgatttg actatatgtt caaccttgct ggcctttatc     1800

atggaattgt tgaagaactc aattgctatg caggaacaga tgcttgcctg taagggcttc     1860

ttggtaatag gatatagcct tgaaaagtct tccaaatctc atgttagcag agcagtactt     1920

gaactttgcc ttgcattttc aaaatatctg agtaatctgc agaatgggat gcccctgctc     1980

aagcaattgt gtgatcacgt tcttcttaat cctgccatat ggattcatac cccagccaag     2040

gttcaactga tgctctatac ttatctgtcc acggaattca ttggtacagt caacatatat     2100

aacaccattc ggagagttgg aacagtgctt ctcatcatgc acacgctgaa gtactactac     2160

tgggcagtga atcctcagga tcgaagtggt atcaccccaa aaggattaga tggaccgcga     2220

cctaatcaaa aagaaatgct ttctctacga gcattcttgt tgatgttcat taagcaatta     2280

gtgatgaagg attctggagt aaaggaagat gaattacagg ccattcttaa ttacctactg     2340

actatgcatg aggatgacaa tctaatggat gtcctacagc tgcttgttgc attaatgtca     2400

gaacacccta actctatgat tcctgctttt gaccaaagga atgggttacg tgttatctac     2460

aaacttctgg catcgaaaag tgaaggaatc agggtacaag ctcttaaggc aatgggttat     2520

tttttaaaac atctggcccc aaagaggaaa gcagaagtca tgcttggaca tggattgttt     2580

tcattgctag ctgaaaggct catgcttcag acaaatttaa tcacaatgac cacatataat     2640

gtgctgtttg agattcttat agaacagatt ggtactcagg tgatacataa acagcatcca     2700

gatcctgatt cttcagtgaa gatacaaaac cctcagatac taaaagtaat tgcgacccta     2760

cttcgaaatt ctccccagtg cccagagagc atggaggttc gcagagcctt tctttctgac     2820

atgattaaac tttttaataa cagtagagaa aacaggagga gcttgctaca atgctctgtg     2880

tggcaagaat ggatgctttc tctctgctat tttaatccta agaattcaga tgagcaaaag     2940

ataacagaaa tggtatacgc catattcaga atcctgcttt accatgcagt caaatatgag     3000

tggggtggct ggcgtgtatg ggtagacact ttatcaatca ctcattcaaa ggtcactttt     3060

gaaatacaca aagaaaacct tgccaatata tttagggaac agcaaggaaa agttgatgaa     3120

gaaatagggc tgtgttcttc aacttcagtt caagcagcct ctggcattag aagggatatt     3180

aatgtttcag taggatccca gcaaccagat acgaaggatt ctcctgtctg tcctcatttc     3240

accacaaatg gtaatgaaaa ttcaagtata gagaagacaa gttcactaga atctgcatct     3300

aatattgaac tgcaaactac taatacatct tatgaagaaa tgaaagctga gcaagaaaat     3360

caggagttac cagatgaagg cactttggaa gaaacactga caaatgagac aaggaatgca     3420

gatgatttag aagtatcttc tgacataata gaagctgtgg ctatttcctc taattctttt     3480

ataacaactg gcaaagattc aatgactgtc agtgaagtaa ctgcttctat aagttctcct     3540

tcagaagagg atgcctcaga gatgccagaa ttcttggata aatctatagt agaggaagag     3600

gaagatgatg attatgtgga actgaaagta gaaggcagtc ctactgagga agctaatcta     3660

cccacagagc tccaagataa cagtttgtct ccagctgcat ctgaagccgg tgaaaaactg     3720

gacatgtttg gtaatgatga caaattaata tttcaagaag gaaaacctgt tactgaaaag     3780

caaactgata ctgaaactca agattctaaa gattctggaa ttcagactat gacagcatca     3840

gggtcttcag ctatgtcacc agaaactact gtttcccaaa tagctgtaga atcagacctt     3900

ggtcagatgc tggaggaagg gaagaaagca actaacctca ctagagaaac caaattaatt     3960

aatgattgtc atggtagtgt ctctgaggct tcttctgagc aaaagattgc gaagttggat     4020

gtttccaatg ttgctacaga tactgagagg ctggagttga aggccagtcc caacgtggaa     4080

gcacctcaac ctcatcgaca tgtgcttgag atatcaaggc aacatgagca gccagggcaa     4140

ggaatagcac cagatgcagt taatggacaa aggagggatt ccagatctac tgtgtttcgt     4200

attcctgagt tcaactggtc tcagatgcat caacgtttgc tcactgatct attattttca     4260

atagaaacag atatacagat gtggagaagc cattcaacaa agacagttat ggacttcgtg     4320

aatagcagtg ataatgtcat ctttgtacac aacacaattc atctcatctc tcaagtgatg     4380

gacaatatgg tcatggcttg tgggggtata ctgccattgc tttcagctgc tacatcggct     4440

acacatgaac tggaaaatat tgaacctact caaggccttt caatagaagc ctctgtgaca     4500

tttttgcaga ggctaattag ccttgtggat gtgcttatat ttgcaagttc tcttggcttt     4560

actgaaattg aagctgaaaa aagtatgtca tctggaggaa ttttgcggca gtgtctccga     4620

ctagtttgtg cagtcgcagt aaggaattgc ttggagtgtc aacagcattc acaactgaaa     4680

actaggggag ataaagcctt gaaaccaatg catagcctta ttcctttagg gaaatctgca     4740

gcgaagagcc cagtggacat tgtgactggc ggtatatctc cagtaagaga tcttgacagg     4800

cttctacagg acatggatat taatcggctt agggcagttg ttttcagaga catagaggat     4860

agcaaacaag ctcaattttt agccttggca gtagtatact ttatctctgt tcttatggtc     4920

tccaagtaca gagacatttt ggaaccccaa aatgaaaggc atagccagtc atgtacagaa     4980

actggcagtg aaaatgagaa tgtatcactc tctgaaatca caccagcagc attcagcact     5040

ttaactacgg catcagtgga agaatctgaa agcacatcat ctgctcgaag gagggactca     5100

ggcattgggg aagaaacagc cactggttta ggaagccatg tggaagtaac tcctcacaca     5160

gcacctcctg gtgtcagtgc aggcccagat gcaatcagcg aggtgctatc tactctttct     5220

ttagaagtca ataagtctcc ggaaaccaaa aatgatagag gaaatgactt ggacactaag     5280

gctacaccgt cagtttcagt ttcaaaaaac gtcaatgtga aagacattct ccgaagcttg     5340

gttaacatac cagcagatgg agtcacagtg gatcctgccc ttctgccacc agcctgcctt     5400

ggagcccttg gtgatctatc tgtggaacaa cccgtgcagt tcagatcttt tgacagaagt     5460

gtcattgttg cagcaaaaaa gtcagcagtc tcaccttcca cctttaatac aagcatacct     5520

accaatgctg tcagtgtggt ttcctcagta gattcagccc aagcctcaga tatgggagga     5580

gaatcaccag gcagtagatc atctaatgca aaattgccct cagttccaac agttgattca     5640

gtttcacaag atccggtttc aaatatgagt attacagaga ggcttgaaca cgctttggaa     5700

aaggcagctc ctctccttcg tgagattttt gtggattttg caccttttct ttctcggaca     5760

cttttgggta gccatggaca agaactgctt atagaaggaa caagtctggt ttgcatgaag     5820

tcgagtagtt cagttgtgga attggttatg ctactgtgtt ctcaggagtg gcaaaattct     5880

attcagaaga atgcaggcct tgcttttatc gaacttgtca atgaaggaag gttgcttagc     5940

cagacaatga aggatcatct agtaagagta gcaaatgaag ctgaatttat cctgagcagg     6000

cagagagcag aagatattca cagacatgcg gaatttgagt cactgtgtgc ccagtattct     6060

gcagacaaac gagaagatga gaagatgtgt gatcatttga taagagcagc aaaatatcgt     6120

gaccacgtga cagcaactca actaatccag aaaattatca acattctcac agacaagcat     6180

ggagcctggg gaaattctgc agtgagtcgt cctcttgagt tctggcgcct tgactactgg     6240

gaagatgact tgcggcgccg gcgacgattt gtgcgtaacc ctctaggatc gacacatcct     6300

gaagcgacac taaaaacagc cgtggaacat gccacagatg aagatatcct tgctaaagga     6360

aaacagtcca tcaggagtca ggctttagga aatcagaact cagaaaacga gatcctcctg     6420

gaaggcgatg atgatactct gtcatccgtg gatgagaaag atttagagaa tcttgccggt     6480

cctgttagcc tgagcacacc agctcagctt gtggccccct ctgttgtagt aaagggcact     6540

ctttctgtca cctcctccga actctatttt gaggtggatg aagaggatcc taacttcaaa     6600

aaaatcgacc ccaagatctt ggcatataca gaagggctgc atggaaaatg gctgttcaca     6660

gagatacgat caatcttttc tcgtcgttat cttttgcaaa atacagccct ggagatcttt     6720

atggcaaaca gagttgctgt gatgttcaac ttcccagacc ctgcaacagt aaagaaagtg     6780

gttaactatc tacctcgtgt tggcgttgga acaagttttg gattgcctca aaccagacgt     6840

atttcattag ctagtccacg tcagcttttt aaggcttcta atatgaccca gcgatggcaa     6900

cacagagaga tatctaattt tgagtacttg atgtttctca acacgatagc aggacggagt     6960

tataatgact taaatcagta tccagtgttt ccttgggtca tcactaatta tgaatcagaa     7020

gaactggatc ttaccttgcc caccaacttc agagatttgt ccaagccaat aggagctctg     7080

aacccaaaaa gagcagcatt cttcgctgag cgttatgaat catgggaaga tgatcaagtt     7140

ccaaagtttc actatggtac tcattactca actgcaagtt ttgttcttgc atggctgcta     7200

agaatagaac cctttacaac ttatttccta aatttgcaag gaggcaaatt tgatcatgca     7260

gatcgaactt tttcatcaat ttccagagct tggcgaaaca gtcagcgtga tacctctgat     7320

attaaggagt tgatccctga attttattat ctccctgaga tgtttgtcaa cttcaataat     7380

tataatcttg gagtgatgga tgatgggaca gtagtgtctg atgtcgaact tcctccttgg     7440

gccaaaacct cagaagaatt tgttcacata aacagattgg ccctggagag tgaatttgtt     7500

tcctgccagc ttcaccaatg gattgatctc atttttggct ataaacagca aggaccagaa     7560

gctgtccgag ccctcaatgt gttctattac ttgacctatg aaggagctgt caatctgaat     7620

tcaataactg atcctgtgtt gagagaggct gttgaagctc aaatccgaag ttttggacag     7680

actccttctc aactactcat agagccccat cctcccagag gttctgccat gcaagtgagt     7740

ccattgatgt tcacagacaa agcccagcag gatgttatca tggtcctcaa gtttccctcc     7800

aactcccctg ttactcacgt ggcagccaac acccagcctg gtttggcaac tcccgctgtg     7860

atcacagtca ctgctaacag gttatttgcg gtgaacaaat ggcacaacct tcctgctcat     7920

caaggtgctg tacaagacca gccataccag ctgccagtgg aaatcgatcc tctcatagcc     7980

agcaatacag gaatgcacag gaggcaaatc actgaccttt tagaccaaag tattcaagtg     8040

cattcccagt gctttgtcat cacttcagac aaccgctata ttctcgtctg tggcttctgg     8100

gataaaagtt tcagagtcta ttctacagac acaggaagat tgatccaagt ggtgtttggc     8160

cattgggatg tcgtcacttg ccttgctcgt tctgagtcat atattggggg aaattgctac     8220

attctctcag ggtcacgtga tgcaactctt ttgctgtggt attggaatgg aaaatgcagt     8280

gggattggag ataacccagg tgagactgct gctcctcggg ccattttgac cggccatgac     8340

tatgaggtca catgtgctgc ggtgtgtgcg gagctaggcc tggtgttgag tggttcacaa     8400

gaaggaccat gtctcataca ttccatgaat ggagacttgt tgaggacctt ggagggtcct     8460

gaaaactgcc tgaaaccaaa actcattcag gcttcaagag agggtcattg tgtcatattc     8520

tatgaaaacg gcctcttctg tacattcagt gtgaatggaa aactccaggc cacgatggaa     8580

acagatgata acataagagc catccagctg agccgagatg ggcagtacct gctcacagga     8640

ggagacagag gagtggtcgt ggtccggcag gtgtcggacc tcaagcagct ctttgcctat     8700

ccaggatgtg acgctggaat ccgggccatg gcgctgtctt acgaccagag gtgcatcatt     8760

tctggcatgg cttcaggaag cattgtgcta ttttacaacg actttaaccg gtggcatcat     8820

gaataccaaa cccgctactg atggtgacag ctgtacatca actctgcccc taggatgagc     8880

agaagtacct ggagcatcat tctcttctac cacatctgaa tgtaacttaa atttgctcaa     8940

agaagcaaaa tattttttaa agttattaat aattgctatt tttgtagtct ttgcttgact     9000

tttttggggg ggattagcaa agcagaaaac tggctgctgg gttctgtagt tttaaaaaat     9060

ctatattttt agtcataatg agaagtctat tttcaccaat tatggaaaca tacagtggag     9120

caagtaaacc acttattcca gctataatat tatgaagaac atttcccatg catctacaag     9180

cttgagaaat aggattttca cagtggggaa gtgggttaca atattggaat aggaaaattt     9240

gatgctgtaa tttgggtcct gtatttttcc aaacaactgt gcttcttcag cactaatatt     9300

tctgggattt aaatagtaat gtttaaatta tggtaaatgt aatttaaaac atctcaatta     9360

agtctgtcta tcaatattgt tcttcaagca tgttttagac ctagaaaagt atggtttggg     9420

ggaggctatt ttattgtgtg gttagcacaa ggaatctaat ttatagcaag tgtgaaatag     9480

ttaccatttt ttcctgatct gtcatcttca tagcacaaca aaacgaaatg atggaaatgc     9540

tcttgagctc acaacatttg tttttctttt aaagtaaatg caagtaccaa agctcactac     9600

tgcggtttgc ctgtgcctgg acaatgaggc ggagccactg ttgttttgtt ggggcacccc     9660

cttccctccc cgggtttgca aatagaggct accgggtgct gtattcagca acacctgttt     9720

tactatttgt tattaaacta tcatctccac cttccttttg attagcaatt tgtactaaga     9780

aacgaaacaa tgttatttgg tggtgtataa ttctactttt ctagtagatt actgtgtgga     9840

attctgtgaa aaatatttga gaaaaggcct gtattgcata aataaattct ttgtatgttg     9900

tgaactttga tctctatttc tcttgcaaca gacttcaagt ggtccctctt tttttcctac     9960

acactcagct cttctctaaa agcaaggatt tggaatgaac aattcagttt gacagaaaaa    10020

gctgaataaa at                                                        10032


<210>  18
<211>  9899
<212>  DNA
<213>  Homo sapiens

<400>  18
agggaaactt ggaggctgcg accagggttt ggcgttgttg tcagcctcgg ggagagagat       60

tggacaaata ttctccaaga ggaggagggc gacgccaagg actttccaca tcaactgctt      120

tggggtatct ccacaagttg gaagagggac cctttcgttt tgcattgcgt gtgttgtgct      180

cattaccagt gcagcgactg ccgtcccagg gtgactctga gttgtccttt atcgtgagct      240

agcaatggct agcgaagaca atcgtgtccc ttccccgcca ccaacaggtg atgacggggg      300

aggtggaggg agagaagaaa cccctactga agggggtgca ttgtctctga aaccagggct      360

ccccatcagg ggcatcagaa tgaaatttgc cgtgttgacc ggtttggttg aagttggaga      420

agtatccaat agggatattg tagaaactgt ctttaacctg ttggtaggag gacagtttga      480

tctggaaatg aatttcatta tccaagaagg tgagagtatt aactgcatgg tggacctact      540

ggaaaaatgt gacattacgt gccaagcaga agtctggagc atgtttacag ccattctgaa      600

gaaaagcata cggaatcttc aagtctgcac tgaagtaggc cttgttgaaa aagtgcttgg      660

gaaaattgaa aaagttgaca atatgatagc agatcttttg gttgacatgt tgggagtgct      720

ggctagctat aatttgacag ttcgcgagct aaagcttttc ttcagtaaac ttcaaggaga      780

taaaggacga tggcctccac atgctgggaa gttgctgtct gtgttaaagc atatgcctca      840

gaagtatggt cctgatgcct tttttaactt tccaggaaag agtgctgcag ctattgcatt      900

acctcctata gccaaatggc cataccagaa tggttttaca tttcatacat ggcttagaat      960

ggatcctgta aataacatca atgtagataa ggataaacca tatttgtatt gtttcagaac     1020

cagcaaaggt cttggctatt ctgctcattt tgttggaggc tgtttgattg taacatcaat     1080

aaagtcaaaa ggaaaaggct ttcaacactg tgtgaaattt gatttcaagc cacaaaagtg     1140

gtatatggtt accatagtac acatctataa ccgatggaag aatagtgaac ttcgatgtta     1200

tgtgaatggt gagctggctt cctatggaga gataacatgg tttgtcaaca ctagcgatac     1260

ctttgacaaa tgtttcctgg gctcatcaga aacagcagat gctaatagag tattctgtgg     1320

tcagatgact gcagtttacc ttttcagtga agctctaaat gcagctcaga tatttgctat     1380

ttatcagttg ggcctgggat acaagggtac atttaaattc aaagcagaaa gcgacctttt     1440

ccttgctgag catcacaaac ttttattgta cgatgggaaa ctctctagtg ccattgcatt     1500

cacgtacaat ccacgggcta cagatgccca gctttgtctt gaatcatctc ctaaggacaa     1560

cccttcaatt tttgttcatt caccacatgc actcatgctc caggatgtaa aggcagtttt     1620

aacacattcc atccaaagtg caatgcattc aattggagga gtacaagtac tatttccact     1680

ttttgcacag ttggattaca ggcaatattt gtctgatgag attgatttga ctatatgttc     1740

aaccttgctg gcctttatca tggaattgtt gaagaactca attgctatgc aggaacagat     1800

gcttgcctgt aagggcttct tggtaatagg atatagcctt gaaaagtctt ccaaatctca     1860

tgttagcaga gcagtacttg aactttgcct tgcattttca aaatatctga gtaatctgca     1920

gaatgggatg cccctgctca agcaattgtg tgatcacgtt cttcttaatc ctgccatatg     1980

gattcatacc ccagccaagg ttcaactgat gctctatact tatctgtcca cggaattcat     2040

tggtacagtc aacatatata acaccattcg gagagttgga acagtgcttc tcatcatgca     2100

cacgctgaag tactactact gggcagtgaa tcctcaggat cgaagtggta tcaccccaaa     2160

aggattagat ggaccgcgac ctaatcaaaa agaaatgctt tctctacgag cattcttgtt     2220

gatgttcatt aagcaattag tgatgaagga ttctggagta aaggaagatg aattacaggc     2280

cattcttaat tacctactga ctatgcatga ggatgacaat ctaatggatg tcctacagct     2340

gcttgttgca ttaatgtcag aacaccctaa ctctatgatt cctgcttttg accaaaggaa     2400

tgggttacgt gttatctaca aacttctggc atcgaaaagt gaaggaatca gggtacaagc     2460

tcttaaggca atgggttatt ttttaaaaca tctggcccca aagaggaaag cagaagtcat     2520

gcttggacat ggattgtttt cattgctagc tgaaaggctc atgcttcaga caaatttaat     2580

cacaatgacc acatataatg tgctgtttga gattcttata gaacagattg gtactcaggt     2640

gatacataaa cagcatccag atcctgattc ttcagtgaag atacaaaacc ctcagatact     2700

aaaagtaatt gcgaccctac ttcgaaattc tccccagtgc ccagagagca tggaggttcg     2760

cagagccttt ctttctgaca tgattaaact ttttaataac agtagagaaa acaggaggag     2820

cttgctacaa tgctctgtgt ggcaagaatg gatgctttct ctctgctatt ttaatcctaa     2880

gaattcagat gagcaaaaga taacagaaat ggtatacgcc atattcagaa tcctgcttta     2940

ccatgcagtc aaatatgagt ggggtggctg gcgtgtatgg gtagacactt tatcaatcac     3000

tcattcaaag gtcacttttg aaatacacaa agaaaacctt gccaatatat ttagggaaca     3060

gcaaggaaaa gttgatgaag aaatagggct gtgttcttca acttcagttc aagcagcctc     3120

tggcattaga agggatatta atgtttcagt aggatcccag caaccagata cgaaggattc     3180

tcctgtctgt cctcatttca ccacaaatgg taatgaaaat tcaagtatag agaagacaag     3240

ttcactagaa tctgcatcta atattgaact gcaaactact aatacatctt atgaagaaat     3300

gaaagctgag caagaaaatc aggagttacc agatgaaggc actttggaag aaacactgac     3360

aaatgagaca aggaatgcag atgatttaga agtatcttct gacataatag aagctgtggc     3420

tatttcctct aattctttta taacaactgg caaagattca atgactgtca gtgaagtaac     3480

tgcttctata agttctcctt cagaagagga tgcctcagag atgccagaat tcttggataa     3540

atctatagta gaggaagagg aagatgatga ttatgtggaa ctgaaagtag aaggcagtcc     3600

tactgaggaa gctaatctac ccacagagct ccaagataac agtttgtctc cagctgcatc     3660

tgaagccggt gaaaaactgg acatgtttgg taatgatgac aaattaatat ttcaagaagg     3720

aaaacctgtt actgaaaagc aaactgatac tgaaactcaa gattctaaag attctggaat     3780

tcagactatg acagcatcag ggtcttcagc tatgtcacca gaaactactg tttcccaaat     3840

agctgtagaa tcagaccttg gtcagatgct ggaggaaggg aagaaagcaa ctaacctcac     3900

tagagaaacc aaattaatta atgattgtca tggtagtgtc tctgaggctt cttctgagca     3960

aaagattgcg aagttggatg tttccaatgt tgctacagat actgagaggc tggagttgaa     4020

ggccagtccc aacgtggaag cacctcaacc tcatcgacat gtgcttgaga tatcaaggca     4080

acatgagcag ccagggcaag gaatagcacc agatgcagtt aatggacaaa ggagggattc     4140

cagatctact gtgtttcgta ttcctgagtt caactggtct cagatgcatc aacgtttgct     4200

cactgatcta ttattttcaa tagaaacaga tatacagatg tggagaagcc attcaacaaa     4260

gacagttatg gacttcgtga atagcagtga taatgtcatc tttgtacaca acacaattca     4320

tctcatctct caagtgatgg acaatatggt catggcttgt gggggtatac tgccattgct     4380

ttcagctgct acatcggcta cacatgaact ggaaaatatt gaacctactc aaggcctttc     4440

aatagaagcc tctgtgacat ttttgcagag gctaattagc cttgtggatg tgcttatatt     4500

tgcaagttct cttggcttta ctgaaattga agctgaaaaa agtatgtcat ctggaggaat     4560

tttgcggcag tgtctccgac tagtttgtgc agtcgcagta aggaattgct tggagtgtca     4620

acagcattca caactgaaaa ctaggggaga taaagccttg aaaccaatgc atagccttat     4680

tcctttaggg aaatctgcag cgaagagccc agtggacatt gtgactggcg gtatatctcc     4740

agtaagagat cttgacaggc ttctacagga catggatatt aatcggctta gggcagttgt     4800

tttcagagac atagaggata gcaaacaagc tcaattttta gccttggcag tagtatactt     4860

tatctctgtt cttatggtct ccaagtacag agacattttg gaaccccaaa atgaaaggca     4920

tagccagtca tgtacagaaa ctggcagtga aaatgagaat gtatcactct ctgaaatcac     4980

accagcagca ttcagcactt taactacggc atcagtggaa gaatctgaaa gcacatcatc     5040

tgctcgaagg agggactcag gcattgggga agaaacagcc actggtttag gaagccatgt     5100

ggaagtaact cctcacacag cacctcctgg tgtcagtgca ggcccagatg caatcagcga     5160

ggtgctatct actctttctt tagaagtcaa taagtctccg gaaaccaaaa atgatagagg     5220

aaatgacttg gacactaagg ctacaccgtc agtttcagtt tcaaaaaacg tcaatgtgaa     5280

agacattctc cgaagcttgg ttaacatacc agcagatgga gtcacagtgg atcctgccct     5340

tctgccacca gcctgccttg gagcccttgg tgatctatct gtggaacaac ccgtgcagtt     5400

cagatctttt gacagaagtg tcattgttgc agcaaaaaag tcagcagtct caccttccac     5460

ctttaataca agcataccta ccaatgctgt cagtgtggtt tcctcagtag attcagccca     5520

agcctcagat atgggaggag aatcaccagg cagtagatca tctaatgcaa aattgccctc     5580

agttccaaca gttgattcag tttcacaaga tccggtttca aatatgagta ttacagagag     5640

gcttgaacac gctttggaaa aggcagctcc tctccttcgt gagatttttg tggattttgc     5700

accttttctt tctcggacac ttttgggtag ccatggacaa gaactgctta tagaaggaac     5760

aagtctggtt tgcatgaagt cgagtagttc agttgtggaa ttggttatgc tactgtgttc     5820

tcaggagtgg caaaattcta ttcagaagaa tgcaggcctt gcttttatcg aacttgtcaa     5880

tgaaggaagg ttgcttagcc agacaatgaa ggatcatcta gtaagagtag caaatgaagc     5940

tgaatttatc ctgagcaggc agagagcaga agatattcac agacatgcgg aatttgagtc     6000

actgtgtgcc cagtattctg cagacaaacg agaagatgag aagatgtgtg atcatttgat     6060

aagagcagca aaatatcgtg accacgtgac agcaactcaa ctaatccaga aaattatcaa     6120

cattctcaca gacaagcatg gagcctgggg aaattctgca gtgagtcgtc ctcttgagtt     6180

ctggcgcctt gactactggg aagatgactt gcggcgccgg cgacgatttg tgcgtaaccc     6240

tctaggatcg acacatcctg aagcgacact aaaaacagcc gtggaacatg tgtgcatttt     6300

taaattgaga gagaacagca aagccacaga tgaagatatc cttgctaaag gaaaacagtc     6360

catcaggagt caggctttag gaaatcagaa ctcagaaaac gagatcctcc tggaaggcga     6420

tgatgatact ctgtcatccg tggatgagaa agatttagag aatcttgccg gtcctgttag     6480

cctgagcaca ccagctcagc ttgtggcccc ctctgttgta gtaaagggca ctctttctgt     6540

cacctcctcc gaactctatt ttgaggtgga tgaagaggat cctaacttca aaaaaatcga     6600

ccccaagatc ttggcatata cagaagggct gcatggaaaa tggctgttca cagagatacg     6660

atcaatcttt tctcgtcgtt atcttttgca aaatacagcc ctggagatct ttatggcaaa     6720

cagagttgct gtgatgttca acttcccaga ccctgcaaca gtaaagaaag tggttaacta     6780

tctacctcgt gttggcgttg gaacaagttt tggattgcct caaaccagac gtatttcatt     6840

agctagtcca cgtcagcttt ttaaggcttc taatatgacc cagcgatggc aacacagaga     6900

gatatctaat tttgagtact tgatgtttct caacacgata gcaggacgga gttataatga     6960

cttaaatcag tatccagtgt ttccttgggt catcactaat tatgaatcag aagaactgga     7020

tcttaccttg cccaccaact tcagagattt gtccaagcca ataggagctc tgaacccaaa     7080

aagagcagca ttcttcgctg agcgttatga atcatgggaa gatgatcaag ttccaaagtt     7140

tcactatggt actcattact caactgcaag ttttgttctt gcatggctgc taagaataga     7200

accctttaca acttatttcc taaatttgca aggaggcaaa tttgatcatg cagatcgaac     7260

tttttcatca atttccagag cttggcgaaa cagtcagcgt gatacctctg atattaagga     7320

gttgatccct gaattttatt atctccctga gatgtttgtc aacttcaata attataatct     7380

tggagtgatg gatgatggga cagtagtgtc tgatgtcgaa cttcctcctt gggccaaaac     7440

ctcagaagaa tttgttcaca taaacagatt ggccctggag agtgaatttg tttcctgcca     7500

gcttcaccaa tggattgatc tcatttttgg ctataaacag caaggaccag aagctgtccg     7560

agccctcaat gtgttctatt acttgaccta tgaaggagct gtcaatctga attcaataac     7620

tgatcctgtg ttgagagagg ctgttgaagc tcaaatccga agttttggac agactccttc     7680

tcaactactc atagagcccc atcctcccag aggttctgcc atgcaagtga gtccattgat     7740

gttcacagac aaagcccagc aggatgttat catggtcctc aagtttccct ccaactcccc     7800

tgttactcac gtggcagcca acacccagcc tggtttggca actcccgctg tgatcacagt     7860

cactgctaac aggttatttg cggtgaacaa atggcacaac cttcctgctc atcaaggtgc     7920

tgtacaagac cagccatacc agctgccagt ggaaatcgat cctctcatag ccagcaatac     7980

aggaatgcac aggaggcaaa tcactgacct tttagaccaa agtattcaag tgcattccca     8040

gtgctttgtc atcacttcag acaaccgcta tattctcgtc tgtggcttct gggataaaag     8100

tttcagagtc tattctacag acacaggaag attgatccaa gtggtgtttg gccattggga     8160

tgtcgtcact tgccttgctc gttctgagtc atatattggg ggaaattgct acattctctc     8220

agggtcacgt gatgcaactc ttttgctgtg gtattggaat ggaaaatgca gtgggattgg     8280

agataaccca ggcagtgaga ctgctgctcc tcgggccatt ttgaccggcc atgactatga     8340

ggtcacatgt gctgcggtgt gtgcggagct aggcctggtg ttgagtggtt cacaagaagg     8400

accatgtctc atacattcca tgaatggaga cttgttgagg accttggagg gtcctgaaaa     8460

ctgcctgaaa ccaaaactca ttcaggcttc aagagagggt cattgtgtca tattctatga     8520

aaacggcctc ttctgtacat tcagtgtgaa tggaaaactc caggccacga tggaaacaga     8580

tgataacata agagccatcc agctgagccg agatgggcag tacctgctca caggaggaga     8640

cagaggagtg gtcgtggtcc ggcaggtgtc ggacctcaag cagctctttg cctatccagg     8700

atgtgacgct ggaatccggg ccatggcgct gtcttacgac cagaggtgca tcatttctgg     8760

catggcttca ggaagcattg tgctatttta caacgacttt aaccggtggc atcatgaata     8820

ccaaacccgc tactgatggt gacagctgta catcaactct gcccctagga tgagcagaag     8880

tacctggagc atcattctct tctaccacat ctgaatgtaa cttaaatttg ctcaaagaag     8940

caaaatattt tttaaagtta ttaataattg ctatttttgt agtctttgct tgactttttt     9000

gggggggatt agcaaagcag aaaactggct gctgggttct gtagttttaa aaaatctata     9060

tttttagtca taatgagaag tctattttca ccaattatgg aaacatacag tggagcaagt     9120

aaaccactta ttccagctat aatattatga agaacatttc ccatgcatct acaagcttga     9180

gaaataggat tttcacagtg gggaagtggg ttacaatatt ggaataggaa aatttgatgc     9240

tgtaatttgg gtcctgtatt tttccaaaca actgtgcttc ttcagcacta atatttctgg     9300

gatttaaata gtaatgttta aattatggta aatgtaattt aaaacatctc aattaagtct     9360

gtctatcaat attgttcttc aagcatgttt tagacctaga aaagtatggt ttgggggagg     9420

ctattttatt gtgtggttag cacaaggaat ctaatttata gcaagtgtga aatagttacc     9480

attttttcct gatctgtcat cttcatagca caacaaaacg aaatgatgga aatgctcttg     9540

agctcacaac atttgttttt cttttaaagt aaatgcaagt accaaagctc actactgcgg     9600

tttgcctgtg cctggacaat gaggcggagc cactgttgtt ttgttggggc acccccttcc     9660

ctccccgggt ttgcaaatag aggctaccgg gtgctgtatt cagcaacacc tgttttacta     9720

tttgttatta aactatcatc tccaccttcc ttttgattag caatttgtac taagaaacga     9780

aacaatgtta tttggtggtg tataattcta cttttctagt agattactgt gtggaattct     9840

gtgaaaaata tttgagaaaa ggcctgtatt gcataaataa attctttgta tgttgtgaa      9899


<210>  19
<211>  4900
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (140)..(3490)

<400>  19
ccttgccaag taacagcttt gctgtccaac atcgtgtgct gcttcgcgag aaagtcacat       60

tcggaccctt tggctagatt gcttattcat agggcttctt gactaaagcc cttggagcac      120

tgggtttttc ttgaagtat atg atc tta gac gaa ttt tac aat gtg aag ttc       172
                     Met Ile Leu Asp Glu Phe Tyr Asn Val Lys Phe          
                     1               5                   10               

tgc ata gat gcc agt caa cca gat gtt gga agc tgg ctc aag tac att        220
Cys Ile Asp Ala Ser Gln Pro Asp Val Gly Ser Trp Leu Lys Tyr Ile           
            15                  20                  25                    

aga ttc gct ggc tgt tat gat cag cac aac ctt gtt gca tgc cag ata        268
Arg Phe Ala Gly Cys Tyr Asp Gln His Asn Leu Val Ala Cys Gln Ile           
        30                  35                  40                        

aat gat cag ata ttc tat aga gta gtt gca gac att gcg ccg gga gag        316
Asn Asp Gln Ile Phe Tyr Arg Val Val Ala Asp Ile Ala Pro Gly Glu           
    45                  50                  55                            

gag ctt ctg ctg ttc atg aag agc gaa gac tat ccc cat gaa act atg        364
Glu Leu Leu Leu Phe Met Lys Ser Glu Asp Tyr Pro His Glu Thr Met           
60                  65                  70                  75            

gcg ccg gat atc cac gaa gaa cgg caa tat cgc tgc gaa gac tgt gac        412
Ala Pro Asp Ile His Glu Glu Arg Gln Tyr Arg Cys Glu Asp Cys Asp           
                80                  85                  90                

cag ctc ttt gaa tct aag gct gaa cta gca gat cac caa aag ttt cca        460
Gln Leu Phe Glu Ser Lys Ala Glu Leu Ala Asp His Gln Lys Phe Pro           
            95                  100                 105                   

tgc agt act cct cac tca gca ttt tca atg gtt gaa gag gac ttt cag        508
Cys Ser Thr Pro His Ser Ala Phe Ser Met Val Glu Glu Asp Phe Gln           
        110                 115                 120                       

caa aaa ctc gaa agc gag aat gat ctc caa gag ata cac acg atc cag        556
Gln Lys Leu Glu Ser Glu Asn Asp Leu Gln Glu Ile His Thr Ile Gln           
    125                 130                 135                           

gag tgt aag gaa tgt gac caa gtt ttt cct gat ttg caa agc ctg gag        604
Glu Cys Lys Glu Cys Asp Gln Val Phe Pro Asp Leu Gln Ser Leu Glu           
140                 145                 150                 155           

aaa cac atg ctg tca cat act gaa gag agg gaa tac aag tgt gat cag        652
Lys His Met Leu Ser His Thr Glu Glu Arg Glu Tyr Lys Cys Asp Gln           
                160                 165                 170               

tgt ccc aag gca ttt aac tgg aag tcc aat tta att cgc cac cag atg        700
Cys Pro Lys Ala Phe Asn Trp Lys Ser Asn Leu Ile Arg His Gln Met           
            175                 180                 185                   

tca cat gac agt gga aag cac tat gaa tgt gaa aac tgt gcc aag cag        748
Ser His Asp Ser Gly Lys His Tyr Glu Cys Glu Asn Cys Ala Lys Gln           
        190                 195                 200                       

gtt ttc acg gac cct agc aac ctt cag cgg cac att cgc tct cag cat        796
Val Phe Thr Asp Pro Ser Asn Leu Gln Arg His Ile Arg Ser Gln His           
    205                 210                 215                           

gtc ggt gcc cgg gcc cat gca tgc ccg gag tgt ggc aaa acg ttt gcc        844
Val Gly Ala Arg Ala His Ala Cys Pro Glu Cys Gly Lys Thr Phe Ala           
220                 225                 230                 235           

act tcg tcg ggc ctc aaa caa cac aag cac atc cac agc agt gtg aag        892
Thr Ser Ser Gly Leu Lys Gln His Lys His Ile His Ser Ser Val Lys           
                240                 245                 250               

ccc ttt atc tgt gag gtc tgc cat aaa tcc tat act cag ttt tca aac        940
Pro Phe Ile Cys Glu Val Cys His Lys Ser Tyr Thr Gln Phe Ser Asn           
            255                 260                 265                   

ctt tgc cgt cat aag cgc atg cat gct gat tgc aga acc caa atc aag        988
Leu Cys Arg His Lys Arg Met His Ala Asp Cys Arg Thr Gln Ile Lys           
        270                 275                 280                       

tgc aaa gac tgt gga caa atg ttc agc act acg tct tcc tta aat aaa       1036
Cys Lys Asp Cys Gly Gln Met Phe Ser Thr Thr Ser Ser Leu Asn Lys           
    285                 290                 295                           

cac agg agg ttt tgt gag ggc aag aac cat ttt gcg gca ggt gga ttt       1084
His Arg Arg Phe Cys Glu Gly Lys Asn His Phe Ala Ala Gly Gly Phe           
300                 305                 310                 315           

ttt ggc caa ggc att tca ctt cct gga acc cca gct atg gat aaa acg       1132
Phe Gly Gln Gly Ile Ser Leu Pro Gly Thr Pro Ala Met Asp Lys Thr           
                320                 325                 330               

tcc atg gtt aat atg agt cat gcc aac ccg ggc ctt gct gac tat ttt       1180
Ser Met Val Asn Met Ser His Ala Asn Pro Gly Leu Ala Asp Tyr Phe           
            335                 340                 345                   

ggc gcc aat agg cat cct gct ggt ctt acc ttt cca aca gct cct gga       1228
Gly Ala Asn Arg His Pro Ala Gly Leu Thr Phe Pro Thr Ala Pro Gly           
        350                 355                 360                       

ttt tct ttt agc ttc cct ggt ctg ttt cct tcc ggc ttg tac cac agg       1276
Phe Ser Phe Ser Phe Pro Gly Leu Phe Pro Ser Gly Leu Tyr His Arg           
    365                 370                 375                           

cct cct ttg ata cct gct agt tct cct gtt aaa gga cta tca agt act       1324
Pro Pro Leu Ile Pro Ala Ser Ser Pro Val Lys Gly Leu Ser Ser Thr           
380                 385                 390                 395           

gaa cag aca aac aaa agt caa agt ccc ctc atg aca cat cct cag ata       1372
Glu Gln Thr Asn Lys Ser Gln Ser Pro Leu Met Thr His Pro Gln Ile           
                400                 405                 410               

ctg cca gct aca cag gat att ttg aag gca cta tct aaa cac cca tct       1420
Leu Pro Ala Thr Gln Asp Ile Leu Lys Ala Leu Ser Lys His Pro Ser           
            415                 420                 425                   

gta ggg gac aat aag cca gtg gag ctc cag ccc gag agg tcc tct gaa       1468
Val Gly Asp Asn Lys Pro Val Glu Leu Gln Pro Glu Arg Ser Ser Glu           
        430                 435                 440                       

gag agg ccc ttt gag aaa atc agt gac cag tca gag agt agt gac ctt       1516
Glu Arg Pro Phe Glu Lys Ile Ser Asp Gln Ser Glu Ser Ser Asp Leu           
    445                 450                 455                           

gat gat gtc agt aca cca agt ggc agt gac ctg gaa aca acc tcg ggc       1564
Asp Asp Val Ser Thr Pro Ser Gly Ser Asp Leu Glu Thr Thr Ser Gly           
460                 465                 470                 475           

tct gat ctg gaa agt gac att gaa agt gat aaa gag aaa ttt aaa gaa       1612
Ser Asp Leu Glu Ser Asp Ile Glu Ser Asp Lys Glu Lys Phe Lys Glu           
                480                 485                 490               

aat ggt aaa atg ttc aaa gac aaa gta agc cct ctt cag aat ctg gct       1660
Asn Gly Lys Met Phe Lys Asp Lys Val Ser Pro Leu Gln Asn Leu Ala           
            495                 500                 505                   

tca ata aat aat aag aaa gaa tac agc aat cat tcc att ttc tca cca       1708
Ser Ile Asn Asn Lys Lys Glu Tyr Ser Asn His Ser Ile Phe Ser Pro           
        510                 515                 520                       

tct tta gag gag cag act gcg gtg tca gga gct gtg aat gat tct ata       1756
Ser Leu Glu Glu Gln Thr Ala Val Ser Gly Ala Val Asn Asp Ser Ile           
    525                 530                 535                           

aag gct att gct tct att gct gaa aaa tac ttt ggt tca aca gga ctg       1804
Lys Ala Ile Ala Ser Ile Ala Glu Lys Tyr Phe Gly Ser Thr Gly Leu           
540                 545                 550                 555           

gtg ggg ctg caa gac aaa aaa gtt gga gct tta cct tac cct tcc atg       1852
Val Gly Leu Gln Asp Lys Lys Val Gly Ala Leu Pro Tyr Pro Ser Met           
                560                 565                 570               

ttt ccc ctc cca ttt ttt cca gca ttc tct caa tca atg tac cca ttt       1900
Phe Pro Leu Pro Phe Phe Pro Ala Phe Ser Gln Ser Met Tyr Pro Phe           
            575                 580                 585                   

cct gat aga gac ttg aga tcg tta cct ttg aaa atg gaa ccc caa tca       1948
Pro Asp Arg Asp Leu Arg Ser Leu Pro Leu Lys Met Glu Pro Gln Ser           
        590                 595                 600                       

cca ggt gaa gta aag aaa ctg cag aag ggc agc tct gag tcc ccc ttt       1996
Pro Gly Glu Val Lys Lys Leu Gln Lys Gly Ser Ser Glu Ser Pro Phe           
    605                 610                 615                           

gat ctc acc act aag cga aag gat gag aag ccc ttg act cca gtc ccc       2044
Asp Leu Thr Thr Lys Arg Lys Asp Glu Lys Pro Leu Thr Pro Val Pro           
620                 625                 630                 635           

tcc aag cct cca gtg aca cct gcc aca agc caa gac cag ccc ctg gat       2092
Ser Lys Pro Pro Val Thr Pro Ala Thr Ser Gln Asp Gln Pro Leu Asp           
                640                 645                 650               

cta agt atg ggc agt agg agt aga gcc agt ggg aca aag ctg act gag       2140
Leu Ser Met Gly Ser Arg Ser Arg Ala Ser Gly Thr Lys Leu Thr Glu           
            655                 660                 665                   

cct cga aaa aac cac gtg ttt ggg gga aaa aaa gga agc aac gtc gaa       2188
Pro Arg Lys Asn His Val Phe Gly Gly Lys Lys Gly Ser Asn Val Glu           
        670                 675                 680                       

tca aga cct gct tca gat ggt tcc ttg cag cat gca aga ccc act cct       2236
Ser Arg Pro Ala Ser Asp Gly Ser Leu Gln His Ala Arg Pro Thr Pro           
    685                 690                 695                           

ttc ttt atg gac cct att tac aga gta gag aaa aga aaa cta act gac       2284
Phe Phe Met Asp Pro Ile Tyr Arg Val Glu Lys Arg Lys Leu Thr Asp           
700                 705                 710                 715           

cca ctt gaa gct tta aaa gag aaa tac ttg agg cct tct cca gga ttc       2332
Pro Leu Glu Ala Leu Lys Glu Lys Tyr Leu Arg Pro Ser Pro Gly Phe           
                720                 725                 730               

ttg ttt cac cca caa ttc caa ctg cct gat cag aga act tgg atg tca       2380
Leu Phe His Pro Gln Phe Gln Leu Pro Asp Gln Arg Thr Trp Met Ser           
            735                 740                 745                   

gct att gaa aac atg gca gaa aag cta gag agc ttc agt gcc ctg aaa       2428
Ala Ile Glu Asn Met Ala Glu Lys Leu Glu Ser Phe Ser Ala Leu Lys           
        750                 755                 760                       

cct gag gcc agt gag ctc tta cag tca gtg ccc tct atg ttc aac ttc       2476
Pro Glu Ala Ser Glu Leu Leu Gln Ser Val Pro Ser Met Phe Asn Phe           
    765                 770                 775                           

agg gcg cct ccc aat gcc ctg cca gag aac ctt ctg cgg aag gga aag       2524
Arg Ala Pro Pro Asn Ala Leu Pro Glu Asn Leu Leu Arg Lys Gly Lys           
780                 785                 790                 795           

gag cgc tat acc tgc aga tac tgt ggc aag att ttt cca agg tct gca       2572
Glu Arg Tyr Thr Cys Arg Tyr Cys Gly Lys Ile Phe Pro Arg Ser Ala           
                800                 805                 810               

aac cta aca cgg cac ttg aga acc cac aca gga gag cag cct tac aga       2620
Asn Leu Thr Arg His Leu Arg Thr His Thr Gly Glu Gln Pro Tyr Arg           
            815                 820                 825                   

tgc aaa tac tgt gac aga tca ttt agc ata tct tct aac ttg caa agg       2668
Cys Lys Tyr Cys Asp Arg Ser Phe Ser Ile Ser Ser Asn Leu Gln Arg           
        830                 835                 840                       

cat gtt cgc aac atc cac aat aaa gag aag cca ttt aag tgt cac tta       2716
His Val Arg Asn Ile His Asn Lys Glu Lys Pro Phe Lys Cys His Leu           
    845                 850                 855                           

tgt gat agg tgt ttt ggt caa caa acc aat tta gac aga cac cta aag       2764
Cys Asp Arg Cys Phe Gly Gln Gln Thr Asn Leu Asp Arg His Leu Lys           
860                 865                 870                 875           

aaa cat gag aat ggg aac atg tcc ggt aca gca aca tcg tcg cct cat       2812
Lys His Glu Asn Gly Asn Met Ser Gly Thr Ala Thr Ser Ser Pro His           
                880                 885                 890               

tct gaa ctg gaa agt aca ggt gcg att ctg gat gac aaa gaa gat gct       2860
Ser Glu Leu Glu Ser Thr Gly Ala Ile Leu Asp Asp Lys Glu Asp Ala           
            895                 900                 905                   

tac ttc aca gaa att cga aat ttc att ggg aac agc aac cat ggc agc       2908
Tyr Phe Thr Glu Ile Arg Asn Phe Ile Gly Asn Ser Asn His Gly Ser           
        910                 915                 920                       

caa tct ccc agg aat gtg gag gag aga atg aat ggc agt cat ttt aaa       2956
Gln Ser Pro Arg Asn Val Glu Glu Arg Met Asn Gly Ser His Phe Lys           
    925                 930                 935                           

gat gaa aag gct ttg gtg acc agt caa aat tca gac ttg ctg gat gat       3004
Asp Glu Lys Ala Leu Val Thr Ser Gln Asn Ser Asp Leu Leu Asp Asp           
940                 945                 950                 955           

gaa gaa gtt gaa gat gag gtg ttg tta gat gag gag gat gaa gac aat       3052
Glu Glu Val Glu Asp Glu Val Leu Leu Asp Glu Glu Asp Glu Asp Asn           
                960                 965                 970               

gat att act gga aaa aca gga aag gaa cca gtg aca agt aat tta cat       3100
Asp Ile Thr Gly Lys Thr Gly Lys Glu Pro Val Thr Ser Asn Leu His           
            975                 980                 985                   

gaa gga aac cct gag gat gac tat gaa gaa acc agt gcc  ctg gag atg      3148
Glu Gly Asn Pro Glu Asp Asp Tyr Glu Glu Thr Ser Ala  Leu Glu Met          
        990                 995                 1000                      

agt tgc  aag aca tcc cca gtg  agg tat aaa gag gaa  gaa tat aaa        3193
Ser Cys  Lys Thr Ser Pro Val  Arg Tyr Lys Glu Glu  Glu Tyr Lys            
    1005                 1010                 1015                        

agt gga  ctt tct gct cta gat  cat ata agg cac ttc  aca gat agc        3238
Ser Gly  Leu Ser Ala Leu Asp  His Ile Arg His Phe  Thr Asp Ser            
    1020                 1025                 1030                        

ctc aaa  atg agg aaa atg gaa  gat aat caa tat tct  gaa gct gag        3283
Leu Lys  Met Arg Lys Met Glu  Asp Asn Gln Tyr Ser  Glu Ala Glu            
    1035                 1040                 1045                        

ctg tct  tct ttt agt act tcc  cat gtg cca gag gaa  ctt aag cag        3328
Leu Ser  Ser Phe Ser Thr Ser  His Val Pro Glu Glu  Leu Lys Gln            
    1050                 1055                 1060                        

ccg tta  cac aga aag tcc aaa  tcg cag gca tat gct  atg atg ctg        3373
Pro Leu  His Arg Lys Ser Lys  Ser Gln Ala Tyr Ala  Met Met Leu            
    1065                 1070                 1075                        

tca ctg  tct gac aag gag tcc  ctc cat tct aca tcc  cac agt tct        3418
Ser Leu  Ser Asp Lys Glu Ser  Leu His Ser Thr Ser  His Ser Ser            
    1080                 1085                 1090                        

tcc aac  gtg tgg cac agt atg  gcc agg gct gcg gcg  gaa tcc agt        3463
Ser Asn  Val Trp His Ser Met  Ala Arg Ala Ala Ala  Glu Ser Ser            
    1095                 1100                 1105                        

gct atc  cag tcc ata agc cac  gta tga cgttatcaag gttgaccaga           3510
Ala Ile  Gln Ser Ile Ser His  Val                                         
    1110                 1115                                             

gtgggaccaa gtccaacagt agcatggctc tttcatatag gactatttac aagactgctg     3570

agcagaatgc cttataaacc tgcagggtca ctcatctaaa gtctagtgac cttaaactga     3630

atgatttaaa aaagaaaaga aagaaaaaag aaactattta ttctcgatat tttgttttgc     3690

acagcaaagg cagctgctga cttctggaag atcaatcaat gcgacttaaa gtgattcagt     3750

gaaaacaaaa aacttggtgg gctgaaggca tcttccagtt taccccacct tagggtatgg     3810

gtgggtgaga agggcagttg agatggcagc attgatatga atgaacactc catagaaact     3870

gaattctctt ttgtacaaga tcacctgaca tgattgggaa cagttgcttt taattacaga     3930

tttaattttt ttcttcgtta aagttttatg taatttaacc ctttgaagac agaagtagtt     3990

ggatgaaatg cacagtcaat tattatagaa actgataaca gggagtactt gttccccctt     4050

ttgccttctt aagtacattg tttaaaacta gggaaaaagg gtatgtgtat attgtaaact     4110

atggatgtta acactcaaag aggttaagtc agtgaagtaa cctattcatc accagtaccg     4170

ctgtaccact aataaattgt ttgccaaatc cttgtaataa catcttaatt ttagacaatc     4230

atgtcactgt ttttaatgtt tatttttttg tgtgtgttgc gtgtatcatg tatttatttg     4290

ttggcaaact attgtttgtt gattaaaata gcactgttcc agtcagccac tactttatga     4350

cgtctgaggc acaccccttt ccgaatttca aggaccaagg tgacccgacc tgtgtatgag     4410

agtgccaaat ggtgtttggc ttttcttaac attccttttt gtttgtttgt tttgttttcc     4470

ttcttaatga actaaatacg aatagatgca acttagtttt tgtaatactg aaatcgattc     4530

aattgtataa acgattataa tttctttcat ggaagcatga ttcttctgat taaaaactgt     4590

actccatatt ttatgctggt tgtctgcaag cttgtgcgat gttatgttca tgttaatcct     4650

atttgtaaaa tgaagtgttc ccaaccttat gttaaaagag agaagtaaat aacagactgt     4710

attcagttat tttgcccttt attgaggaac cagatttgtt ttctttttgt ttgtaatctc     4770

attttgaaat aatcagcaag ttgaggtact ttcttcaaat gctttgtaca atataaactg     4830

ttatgccttt cagtgcatta ctatgggagg agcaactaaa aaataaagac ttacaaaaag     4890

gagtattttt                                                            4900


<210>  20
<211>  1116
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ile Leu Asp Glu Phe Tyr Asn Val Lys Phe Cys Ile Asp Ala Ser 
1               5                   10                  15      


Gln Pro Asp Val Gly Ser Trp Leu Lys Tyr Ile Arg Phe Ala Gly Cys 
            20                  25                  30          


Tyr Asp Gln His Asn Leu Val Ala Cys Gln Ile Asn Asp Gln Ile Phe 
        35                  40                  45              


Tyr Arg Val Val Ala Asp Ile Ala Pro Gly Glu Glu Leu Leu Leu Phe 
    50                  55                  60                  


Met Lys Ser Glu Asp Tyr Pro His Glu Thr Met Ala Pro Asp Ile His 
65                  70                  75                  80  


Glu Glu Arg Gln Tyr Arg Cys Glu Asp Cys Asp Gln Leu Phe Glu Ser 
                85                  90                  95      


Lys Ala Glu Leu Ala Asp His Gln Lys Phe Pro Cys Ser Thr Pro His 
            100                 105                 110         


Ser Ala Phe Ser Met Val Glu Glu Asp Phe Gln Gln Lys Leu Glu Ser 
        115                 120                 125             


Glu Asn Asp Leu Gln Glu Ile His Thr Ile Gln Glu Cys Lys Glu Cys 
    130                 135                 140                 


Asp Gln Val Phe Pro Asp Leu Gln Ser Leu Glu Lys His Met Leu Ser 
145                 150                 155                 160 


His Thr Glu Glu Arg Glu Tyr Lys Cys Asp Gln Cys Pro Lys Ala Phe 
                165                 170                 175     


Asn Trp Lys Ser Asn Leu Ile Arg His Gln Met Ser His Asp Ser Gly 
            180                 185                 190         


Lys His Tyr Glu Cys Glu Asn Cys Ala Lys Gln Val Phe Thr Asp Pro 
        195                 200                 205             


Ser Asn Leu Gln Arg His Ile Arg Ser Gln His Val Gly Ala Arg Ala 
    210                 215                 220                 


His Ala Cys Pro Glu Cys Gly Lys Thr Phe Ala Thr Ser Ser Gly Leu 
225                 230                 235                 240 


Lys Gln His Lys His Ile His Ser Ser Val Lys Pro Phe Ile Cys Glu 
                245                 250                 255     


Val Cys His Lys Ser Tyr Thr Gln Phe Ser Asn Leu Cys Arg His Lys 
            260                 265                 270         


Arg Met His Ala Asp Cys Arg Thr Gln Ile Lys Cys Lys Asp Cys Gly 
        275                 280                 285             


Gln Met Phe Ser Thr Thr Ser Ser Leu Asn Lys His Arg Arg Phe Cys 
    290                 295                 300                 


Glu Gly Lys Asn His Phe Ala Ala Gly Gly Phe Phe Gly Gln Gly Ile 
305                 310                 315                 320 


Ser Leu Pro Gly Thr Pro Ala Met Asp Lys Thr Ser Met Val Asn Met 
                325                 330                 335     


Ser His Ala Asn Pro Gly Leu Ala Asp Tyr Phe Gly Ala Asn Arg His 
            340                 345                 350         


Pro Ala Gly Leu Thr Phe Pro Thr Ala Pro Gly Phe Ser Phe Ser Phe 
        355                 360                 365             


Pro Gly Leu Phe Pro Ser Gly Leu Tyr His Arg Pro Pro Leu Ile Pro 
    370                 375                 380                 


Ala Ser Ser Pro Val Lys Gly Leu Ser Ser Thr Glu Gln Thr Asn Lys 
385                 390                 395                 400 


Ser Gln Ser Pro Leu Met Thr His Pro Gln Ile Leu Pro Ala Thr Gln 
                405                 410                 415     


Asp Ile Leu Lys Ala Leu Ser Lys His Pro Ser Val Gly Asp Asn Lys 
            420                 425                 430         


Pro Val Glu Leu Gln Pro Glu Arg Ser Ser Glu Glu Arg Pro Phe Glu 
        435                 440                 445             


Lys Ile Ser Asp Gln Ser Glu Ser Ser Asp Leu Asp Asp Val Ser Thr 
    450                 455                 460                 


Pro Ser Gly Ser Asp Leu Glu Thr Thr Ser Gly Ser Asp Leu Glu Ser 
465                 470                 475                 480 


Asp Ile Glu Ser Asp Lys Glu Lys Phe Lys Glu Asn Gly Lys Met Phe 
                485                 490                 495     


Lys Asp Lys Val Ser Pro Leu Gln Asn Leu Ala Ser Ile Asn Asn Lys 
            500                 505                 510         


Lys Glu Tyr Ser Asn His Ser Ile Phe Ser Pro Ser Leu Glu Glu Gln 
        515                 520                 525             


Thr Ala Val Ser Gly Ala Val Asn Asp Ser Ile Lys Ala Ile Ala Ser 
    530                 535                 540                 


Ile Ala Glu Lys Tyr Phe Gly Ser Thr Gly Leu Val Gly Leu Gln Asp 
545                 550                 555                 560 


Lys Lys Val Gly Ala Leu Pro Tyr Pro Ser Met Phe Pro Leu Pro Phe 
                565                 570                 575     


Phe Pro Ala Phe Ser Gln Ser Met Tyr Pro Phe Pro Asp Arg Asp Leu 
            580                 585                 590         


Arg Ser Leu Pro Leu Lys Met Glu Pro Gln Ser Pro Gly Glu Val Lys 
        595                 600                 605             


Lys Leu Gln Lys Gly Ser Ser Glu Ser Pro Phe Asp Leu Thr Thr Lys 
    610                 615                 620                 


Arg Lys Asp Glu Lys Pro Leu Thr Pro Val Pro Ser Lys Pro Pro Val 
625                 630                 635                 640 


Thr Pro Ala Thr Ser Gln Asp Gln Pro Leu Asp Leu Ser Met Gly Ser 
                645                 650                 655     


Arg Ser Arg Ala Ser Gly Thr Lys Leu Thr Glu Pro Arg Lys Asn His 
            660                 665                 670         


Val Phe Gly Gly Lys Lys Gly Ser Asn Val Glu Ser Arg Pro Ala Ser 
        675                 680                 685             


Asp Gly Ser Leu Gln His Ala Arg Pro Thr Pro Phe Phe Met Asp Pro 
    690                 695                 700                 


Ile Tyr Arg Val Glu Lys Arg Lys Leu Thr Asp Pro Leu Glu Ala Leu 
705                 710                 715                 720 


Lys Glu Lys Tyr Leu Arg Pro Ser Pro Gly Phe Leu Phe His Pro Gln 
                725                 730                 735     


Phe Gln Leu Pro Asp Gln Arg Thr Trp Met Ser Ala Ile Glu Asn Met 
            740                 745                 750         


Ala Glu Lys Leu Glu Ser Phe Ser Ala Leu Lys Pro Glu Ala Ser Glu 
        755                 760                 765             


Leu Leu Gln Ser Val Pro Ser Met Phe Asn Phe Arg Ala Pro Pro Asn 
    770                 775                 780                 


Ala Leu Pro Glu Asn Leu Leu Arg Lys Gly Lys Glu Arg Tyr Thr Cys 
785                 790                 795                 800 


Arg Tyr Cys Gly Lys Ile Phe Pro Arg Ser Ala Asn Leu Thr Arg His 
                805                 810                 815     


Leu Arg Thr His Thr Gly Glu Gln Pro Tyr Arg Cys Lys Tyr Cys Asp 
            820                 825                 830         


Arg Ser Phe Ser Ile Ser Ser Asn Leu Gln Arg His Val Arg Asn Ile 
        835                 840                 845             


His Asn Lys Glu Lys Pro Phe Lys Cys His Leu Cys Asp Arg Cys Phe 
    850                 855                 860                 


Gly Gln Gln Thr Asn Leu Asp Arg His Leu Lys Lys His Glu Asn Gly 
865                 870                 875                 880 


Asn Met Ser Gly Thr Ala Thr Ser Ser Pro His Ser Glu Leu Glu Ser 
                885                 890                 895     


Thr Gly Ala Ile Leu Asp Asp Lys Glu Asp Ala Tyr Phe Thr Glu Ile 
            900                 905                 910         


Arg Asn Phe Ile Gly Asn Ser Asn His Gly Ser Gln Ser Pro Arg Asn 
        915                 920                 925             


Val Glu Glu Arg Met Asn Gly Ser His Phe Lys Asp Glu Lys Ala Leu 
    930                 935                 940                 


Val Thr Ser Gln Asn Ser Asp Leu Leu Asp Asp Glu Glu Val Glu Asp 
945                 950                 955                 960 


Glu Val Leu Leu Asp Glu Glu Asp Glu Asp Asn Asp Ile Thr Gly Lys 
                965                 970                 975     


Thr Gly Lys Glu Pro Val Thr Ser Asn Leu His Glu Gly Asn Pro Glu 
            980                 985                 990         


Asp Asp Tyr Glu Glu Thr Ser Ala  Leu Glu Met Ser Cys  Lys Thr Ser 
        995                 1000                 1005             


Pro Val  Arg Tyr Lys Glu Glu  Glu Tyr Lys Ser Gly  Leu Ser Ala 
    1010                 1015                 1020             


Leu Asp  His Ile Arg His Phe  Thr Asp Ser Leu Lys  Met Arg Lys 
    1025                 1030                 1035             


Met Glu  Asp Asn Gln Tyr Ser  Glu Ala Glu Leu Ser  Ser Phe Ser 
    1040                 1045                 1050             


Thr Ser  His Val Pro Glu Glu  Leu Lys Gln Pro Leu  His Arg Lys 
    1055                 1060                 1065             


Ser Lys  Ser Gln Ala Tyr Ala  Met Met Leu Ser Leu  Ser Asp Lys 
    1070                 1075                 1080             


Glu Ser  Leu His Ser Thr Ser  His Ser Ser Ser Asn  Val Trp His 
    1085                 1090                 1095             


Ser Met  Ala Arg Ala Ala Ala  Glu Ser Ser Ala Ile  Gln Ser Ile 
    1100                 1105                 1110             


Ser His  Val 
    1115     


<210>  21
<211>  5740
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1202)..(4330)

<400>  21
cacacacaca cacacacacc acacttgtgc tttcaagaca tcgaaacgga ggctatttcc       60

ctggggaaag aaatcctgcc tggcgagatc tccccattgg ttgtttaccc ggagaaatct      120

acatgtttaa gggggatggt gcatccataa tcagtctgtc cctataggac ttgggtcttg      180

gcgacctttt tgtgacctct cccgccagag gaggctgctg tcactttaaa aatttaaaag      240

aggagcccgt ctggcttccg atcagatcac tctgggcggc gggagatagc tccctttctc      300

cctcgccccg ggttctttct ggatggccga gcagatcctc tttaaagaga cagttcatga      360

aatagaaacc cggcggctga gcttggagtt gcgaaagggg acgatcccgt gagggtccag      420

gacccgcgaa ggcgctgcgg aggatctgaa agggggatag agctcccctc gcctccccag      480

gccccccacc ttttcaaact ctcctcctcc tgcttgtttt cccccattgg aactgggaag      540

gagaagtaga agttttagtg ggtttcagat aactttcatt acacatcggg ctgataagag      600

caagagaaag tgagaaaaga gggaggtgat gtgaaccaga aggaatagct ccgagctcat      660

ttaggaaggg ggaaaaagcc aaaacacacc aaacccgggt cacccagacg aaagaagact      720

tcatttcttg tattaaaaat acactgttgg cggacaataa atccgaaacg cgtggtcctg      780

gagagcagat cctagagacg gacaaagttg tcagagaccc atttggaaat cgagacgcga      840

ggcttttaaa aaattattat tattattttt aaacatctct aaatgttgct cgggatcgtt      900

tgaaaggatt ttcgtgcagg agcgttgggg gctgctgatt attttatttt gtttattttg      960

attcttctgt gaatgcctat tattgctgag ttgaggccat agaaatctaa agatcttaga     1020

cgaattttac aatgtgaagt tctgcataga tgccagtcaa ccagatgttg gaagctggct     1080

caagtacatt agattcgctg gctgttatga tcagcacaac cttgttgcat gccagataaa     1140

tgatcagata ttctatagag tagttgcaga cattgcgccg ggagaggagc ttctgctgtt     1200

c atg aag agc gaa gac tat ccc cat gaa act atg gcg ccg gat atc cac     1249
  Met Lys Ser Glu Asp Tyr Pro His Glu Thr Met Ala Pro Asp Ile His         
  1               5                   10                  15              

gaa gaa cgg caa tat cgc tgc gaa gac tgt gac cag ctc ttt gaa tct       1297
Glu Glu Arg Gln Tyr Arg Cys Glu Asp Cys Asp Gln Leu Phe Glu Ser           
            20                  25                  30                    

aag gct gaa cta gca gat cac caa aag ttt cca tgc agt act cct cac       1345
Lys Ala Glu Leu Ala Asp His Gln Lys Phe Pro Cys Ser Thr Pro His           
        35                  40                  45                        

tca gca ttt tca atg gtt gaa gag gac ttt cag caa aaa ctc gaa agc       1393
Ser Ala Phe Ser Met Val Glu Glu Asp Phe Gln Gln Lys Leu Glu Ser           
    50                  55                  60                            

gag aat gat ctc caa gag ata cac acg atc cag gag tgt aag gaa tgt       1441
Glu Asn Asp Leu Gln Glu Ile His Thr Ile Gln Glu Cys Lys Glu Cys           
65                  70                  75                  80            

gac caa gtt ttt cct gat ttg caa agc ctg gag aaa cac atg ctg tca       1489
Asp Gln Val Phe Pro Asp Leu Gln Ser Leu Glu Lys His Met Leu Ser           
                85                  90                  95                

cat act gaa gag agg gaa tac aag tgt gat cag tgt ccc aag gca ttt       1537
His Thr Glu Glu Arg Glu Tyr Lys Cys Asp Gln Cys Pro Lys Ala Phe           
            100                 105                 110                   

aac tgg aag tcc aat tta att cgc cac cag atg tca cat gac agt gga       1585
Asn Trp Lys Ser Asn Leu Ile Arg His Gln Met Ser His Asp Ser Gly           
        115                 120                 125                       

aag cac tat gaa tgt gaa aac tgt gcc aag gtt ttc acg gac cct agc       1633
Lys His Tyr Glu Cys Glu Asn Cys Ala Lys Val Phe Thr Asp Pro Ser           
    130                 135                 140                           

aac ctt cag cgg cac att cgc tct cag cat gtc ggt gcc cgg gcc cat       1681
Asn Leu Gln Arg His Ile Arg Ser Gln His Val Gly Ala Arg Ala His           
145                 150                 155                 160           

gca tgc ccg gag tgt ggc aaa acg ttt gcc act tcg tcg ggc ctc aaa       1729
Ala Cys Pro Glu Cys Gly Lys Thr Phe Ala Thr Ser Ser Gly Leu Lys           
                165                 170                 175               

caa cac aag cac atc cac agc agt gtg aag ccc ttt atc tgt gag gtc       1777
Gln His Lys His Ile His Ser Ser Val Lys Pro Phe Ile Cys Glu Val           
            180                 185                 190                   

tgc cat aaa tcc tat act cag ttt tca aac ctt tgc cgt cat aag cgc       1825
Cys His Lys Ser Tyr Thr Gln Phe Ser Asn Leu Cys Arg His Lys Arg           
        195                 200                 205                       

atg cat gct gat tgc aga acc caa atc aag tgc aaa gac tgt gga caa       1873
Met His Ala Asp Cys Arg Thr Gln Ile Lys Cys Lys Asp Cys Gly Gln           
    210                 215                 220                           

atg ttc agc act acg tct tcc tta aat aaa cac agg agg ttt tgt gag       1921
Met Phe Ser Thr Thr Ser Ser Leu Asn Lys His Arg Arg Phe Cys Glu           
225                 230                 235                 240           

ggc aag aac cat ttt gcg gca ggt gga ttt ttt ggc caa ggc att tca       1969
Gly Lys Asn His Phe Ala Ala Gly Gly Phe Phe Gly Gln Gly Ile Ser           
                245                 250                 255               

ctt cct gga acc cca gct atg gat aaa acg tcc atg gtt aat atg agt       2017
Leu Pro Gly Thr Pro Ala Met Asp Lys Thr Ser Met Val Asn Met Ser           
            260                 265                 270                   

cat gcc aac ccg ggc ctt gct gac tat ttt ggc gcc aat agg cat cct       2065
His Ala Asn Pro Gly Leu Ala Asp Tyr Phe Gly Ala Asn Arg His Pro           
        275                 280                 285                       

gct ggt ctt acc ttt cca aca gct cct gga ttt tct ttt agc ttc cct       2113
Ala Gly Leu Thr Phe Pro Thr Ala Pro Gly Phe Ser Phe Ser Phe Pro           
    290                 295                 300                           

ggt ctg ttt cct tcc ggc ttg tac cac agg cct cct ttg ata cct gct       2161
Gly Leu Phe Pro Ser Gly Leu Tyr His Arg Pro Pro Leu Ile Pro Ala           
305                 310                 315                 320           

agt tct cct gtt aaa gga cta tca agt act gaa cag aca aac aaa agt       2209
Ser Ser Pro Val Lys Gly Leu Ser Ser Thr Glu Gln Thr Asn Lys Ser           
                325                 330                 335               

caa agt ccc ctc atg aca cat cct cag ata ctg cca gct aca cag gat       2257
Gln Ser Pro Leu Met Thr His Pro Gln Ile Leu Pro Ala Thr Gln Asp           
            340                 345                 350                   

att ttg aag gca cta tct aaa cac cca tct gta ggg gac aat aag cca       2305
Ile Leu Lys Ala Leu Ser Lys His Pro Ser Val Gly Asp Asn Lys Pro           
        355                 360                 365                       

gtg gag ctc cag ccc gag agg tcc tct gaa gag agg ccc ttt gag aaa       2353
Val Glu Leu Gln Pro Glu Arg Ser Ser Glu Glu Arg Pro Phe Glu Lys           
    370                 375                 380                           

atc agt gac cag tca gag agt agt gac ctt gat gat gtc agt aca cca       2401
Ile Ser Asp Gln Ser Glu Ser Ser Asp Leu Asp Asp Val Ser Thr Pro           
385                 390                 395                 400           

agt ggc agt gac ctg gaa aca acc tcg ggc tct gat ctg gaa agt gac       2449
Ser Gly Ser Asp Leu Glu Thr Thr Ser Gly Ser Asp Leu Glu Ser Asp           
                405                 410                 415               

att gaa agt gat aaa gag aaa ttt aaa gaa aat ggt aaa atg ttc aaa       2497
Ile Glu Ser Asp Lys Glu Lys Phe Lys Glu Asn Gly Lys Met Phe Lys           
            420                 425                 430                   

gac aaa gta agc cct ctt cag aat ctg gct tca ata aat aat aag aaa       2545
Asp Lys Val Ser Pro Leu Gln Asn Leu Ala Ser Ile Asn Asn Lys Lys           
        435                 440                 445                       

gaa tac agc aat cat tcc att ttc tca cca tct tta gag gag cag act       2593
Glu Tyr Ser Asn His Ser Ile Phe Ser Pro Ser Leu Glu Glu Gln Thr           
    450                 455                 460                           

gcg gtg tca gga gct gtg aat gat tct ata aag gct att gct tct att       2641
Ala Val Ser Gly Ala Val Asn Asp Ser Ile Lys Ala Ile Ala Ser Ile           
465                 470                 475                 480           

gct gaa aaa tac ttt ggt tca aca gga ctg gtg ggg ctg caa gac aaa       2689
Ala Glu Lys Tyr Phe Gly Ser Thr Gly Leu Val Gly Leu Gln Asp Lys           
                485                 490                 495               

aaa gtt gga gct tta cct tac cct tcc atg ttt ccc ctc cca ttt ttt       2737
Lys Val Gly Ala Leu Pro Tyr Pro Ser Met Phe Pro Leu Pro Phe Phe           
            500                 505                 510                   

cca gca ttc tct caa tca atg tac cca ttt cct gat aga gac ttg aga       2785
Pro Ala Phe Ser Gln Ser Met Tyr Pro Phe Pro Asp Arg Asp Leu Arg           
        515                 520                 525                       

tcg tta cct ttg aaa atg gaa ccc caa tca cca ggt gaa gta aag aaa       2833
Ser Leu Pro Leu Lys Met Glu Pro Gln Ser Pro Gly Glu Val Lys Lys           
    530                 535                 540                           

ctg cag aag ggc agc tct gag tcc ccc ttt gat ctc acc act aag cga       2881
Leu Gln Lys Gly Ser Ser Glu Ser Pro Phe Asp Leu Thr Thr Lys Arg           
545                 550                 555                 560           

aag gat gag aag ccc ttg act cca gtc ccc tcc aag cct cca gtg aca       2929
Lys Asp Glu Lys Pro Leu Thr Pro Val Pro Ser Lys Pro Pro Val Thr           
                565                 570                 575               

cct gcc aca agc caa gac cag ccc ctg gat cta agt atg ggc agt agg       2977
Pro Ala Thr Ser Gln Asp Gln Pro Leu Asp Leu Ser Met Gly Ser Arg           
            580                 585                 590                   

agt aga gcc agt ggg aca aag ctg act gag cct cga aaa aac cac gtg       3025
Ser Arg Ala Ser Gly Thr Lys Leu Thr Glu Pro Arg Lys Asn His Val           
        595                 600                 605                       

ttt ggg gga aaa aaa gga agc aac gtc gaa tca aga cct gct tca gat       3073
Phe Gly Gly Lys Lys Gly Ser Asn Val Glu Ser Arg Pro Ala Ser Asp           
    610                 615                 620                           

ggt tcc ttg cag cat gca aga ccc act cct ttc ttt atg gac cct att       3121
Gly Ser Leu Gln His Ala Arg Pro Thr Pro Phe Phe Met Asp Pro Ile           
625                 630                 635                 640           

tac aga gta gag aaa aga aaa cta act gac cca ctt gaa gct tta aaa       3169
Tyr Arg Val Glu Lys Arg Lys Leu Thr Asp Pro Leu Glu Ala Leu Lys           
                645                 650                 655               

gag aaa tac ttg agg cct tct cca gga ttc ttg ttt cac cca caa atg       3217
Glu Lys Tyr Leu Arg Pro Ser Pro Gly Phe Leu Phe His Pro Gln Met           
            660                 665                 670                   

tca gct att gaa aac atg gca gaa aag cta gag agc ttc agt gcc ctg       3265
Ser Ala Ile Glu Asn Met Ala Glu Lys Leu Glu Ser Phe Ser Ala Leu           
        675                 680                 685                       

aaa cct gag gcc agt gag ctc tta cag tca gtg ccc tct atg ttc aac       3313
Lys Pro Glu Ala Ser Glu Leu Leu Gln Ser Val Pro Ser Met Phe Asn           
    690                 695                 700                           

ttc agg gcg cct ccc aat gcc ctg cca gag aac ctt ctg cgg aag gga       3361
Phe Arg Ala Pro Pro Asn Ala Leu Pro Glu Asn Leu Leu Arg Lys Gly           
705                 710                 715                 720           

aag gag cgc tat acc tgc aga tac tgt ggc aag att ttt cca agg tct       3409
Lys Glu Arg Tyr Thr Cys Arg Tyr Cys Gly Lys Ile Phe Pro Arg Ser           
                725                 730                 735               

gca aac cta aca cgg cac ttg aga acc cac aca gga gag cag cct tac       3457
Ala Asn Leu Thr Arg His Leu Arg Thr His Thr Gly Glu Gln Pro Tyr           
            740                 745                 750                   

aga tgc aaa tac tgt gac aga tca ttt agc ata tct tct aac ttg caa       3505
Arg Cys Lys Tyr Cys Asp Arg Ser Phe Ser Ile Ser Ser Asn Leu Gln           
        755                 760                 765                       

agg cat gtt cgc aac atc cac aat aaa gag aag cca ttt aag tgt cac       3553
Arg His Val Arg Asn Ile His Asn Lys Glu Lys Pro Phe Lys Cys His           
    770                 775                 780                           

tta tgt gat agg tgt ttt ggt caa caa acc aat tta gac aga cac cta       3601
Leu Cys Asp Arg Cys Phe Gly Gln Gln Thr Asn Leu Asp Arg His Leu           
785                 790                 795                 800           

aag aaa cat gag aat ggg aac atg tcc ggt aca gca aca tcg tcg cct       3649
Lys Lys His Glu Asn Gly Asn Met Ser Gly Thr Ala Thr Ser Ser Pro           
                805                 810                 815               

cat tct gaa ctg gaa agt aca ggt gcg att ctg gat gac aaa gaa gat       3697
His Ser Glu Leu Glu Ser Thr Gly Ala Ile Leu Asp Asp Lys Glu Asp           
            820                 825                 830                   

gct tac ttc aca gaa att cga aat ttc att ggg aac agc aac cat ggc       3745
Ala Tyr Phe Thr Glu Ile Arg Asn Phe Ile Gly Asn Ser Asn His Gly           
        835                 840                 845                       

agc caa tct ccc agg aat gtg gag gag aga atg aat ggc agt cat ttt       3793
Ser Gln Ser Pro Arg Asn Val Glu Glu Arg Met Asn Gly Ser His Phe           
    850                 855                 860                           

aaa gat gaa aag gct ttg gtg acc agt caa aat tca gac ttg ctg gat       3841
Lys Asp Glu Lys Ala Leu Val Thr Ser Gln Asn Ser Asp Leu Leu Asp           
865                 870                 875                 880           

gat gaa gaa gtt gaa gat gag gtg ttg tta gat gag gag gat gaa gac       3889
Asp Glu Glu Val Glu Asp Glu Val Leu Leu Asp Glu Glu Asp Glu Asp           
                885                 890                 895               

aat gat att act gga aaa aca gga aag gaa cca gtg aca agt aat tta       3937
Asn Asp Ile Thr Gly Lys Thr Gly Lys Glu Pro Val Thr Ser Asn Leu           
            900                 905                 910                   

cat gaa gga aac cct gag gat gac tat gaa gaa acc agt gcc ctg gag       3985
His Glu Gly Asn Pro Glu Asp Asp Tyr Glu Glu Thr Ser Ala Leu Glu           
        915                 920                 925                       

atg agt tgc aag aca tcc cca gtg agg tat aaa gag gaa gaa tat aaa       4033
Met Ser Cys Lys Thr Ser Pro Val Arg Tyr Lys Glu Glu Glu Tyr Lys           
    930                 935                 940                           

agt gga ctt tct gct cta gat cat ata agg cac ttc aca gat agc ctc       4081
Ser Gly Leu Ser Ala Leu Asp His Ile Arg His Phe Thr Asp Ser Leu           
945                 950                 955                 960           

aaa atg agg aaa atg gaa gat aat caa tat tct gaa gct gag ctg tct       4129
Lys Met Arg Lys Met Glu Asp Asn Gln Tyr Ser Glu Ala Glu Leu Ser           
                965                 970                 975               

tct ttt agt act tcc cat gtg cca gag gaa ctt aag cag ccg tta cac       4177
Ser Phe Ser Thr Ser His Val Pro Glu Glu Leu Lys Gln Pro Leu His           
            980                 985                 990                   

aga aag tcc aaa tcg cag gca tat  gct atg atg ctg tca  ctg tct gac     4225
Arg Lys Ser Lys Ser Gln Ala Tyr  Ala Met Met Leu Ser  Leu Ser Asp         
        995                 1000                 1005                     

aag gag  tcc ctc cat tct aca  tcc cac agt tct tcc  aac gtg tgg        4270
Lys Glu  Ser Leu His Ser Thr  Ser His Ser Ser Ser  Asn Val Trp            
    1010                 1015                 1020                        

cac agt  atg gcc agg gct gcg  gcg gaa tcc agt gct  atc cag tcc        4315
His Ser  Met Ala Arg Ala Ala  Ala Glu Ser Ser Ala  Ile Gln Ser            
    1025                 1030                 1035                        

ata agc  cac gta tga cgttatcaag gttgaccaga gtgggaccaa gtccaacagt      4370
Ile Ser  His Val                                                          
    1040                                                                  

agcatggctc tttcatatag gactatttac aagactgctg agcagaatgc cttataaacc     4430

tgcagggtca ctcatctaaa gtctagtgac cttaaactga atgatttaaa aaagaaaaga     4490

aagaaaaaag aaactattta ttctcgatat tttgttttgc acagcaaagg cagctgctga     4550

cttctggaag atcaatcaat gcgacttaaa gtgattcagt gaaaacaaaa aacttggtgg     4610

gctgaaggca tcttccagtt taccccacct tagggtatgg gtgggtgaga agggcagttg     4670

agatggcagc attgatatga atgaacactc catagaaact gaattctctt ttgtacaaga     4730

tcacctgaca tgattgggaa cagttgcttt taattacaga tttaattttt ttcttcgtta     4790

aagttttatg taatttaacc ctttgaagac agaagtagtt ggatgaaatg cacagtcaat     4850

tattatagaa actgataaca gggagtactt gttccccctt ttgccttctt aagtacattg     4910

tttaaaacta gggaaaaagg gtatgtgtat attgtaaact atggatgtta acactcaaag     4970

aggttaagtc agtgaagtaa cctattcatc accagtaccg ctgtaccact aataaattgt     5030

ttgccaaatc cttgtaataa catcttaatt ttagacaatc atgtcactgt ttttaatgtt     5090

tatttttttg tgtgtgttgc gtgtatcatg tatttatttg ttggcaaact attgtttgtt     5150

gattaaaata gcactgttcc agtcagccac tactttatga cgtctgaggc acaccccttt     5210

ccgaatttca aggaccaagg tgacccgacc tgtgtatgag agtgccaaat ggtgtttggc     5270

ttttcttaac attccttttt gtttgtttgt tttgttttcc ttcttaatga actaaatacg     5330

aatagatgca acttagtttt tgtaatactg aaatcgattc aattgtataa acgattataa     5390

tttctttcat ggaagcatga ttcttctgat taaaaactgt actccatatt ttatgctggt     5450

tgtctgcaag cttgtgcgat gttatgttca tgttaatcct atttgtaaaa tgaagtgttc     5510

ccaaccttat gttaaaagag agaagtaaat aacagactgt attcagttat tttgcccttt     5570

attgaggaac cagatttgtt ttctttttgt ttgtaatctc attttgaaat aatcagcaag     5630

ttgaggtact ttcttcaaat gctttgtaca atataaactg ttatgccttt cagtgcatta     5690

ctatgggagg agcaactaaa aaataaagac ttacaaaaag gagtattttt                5740


<210>  22
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Ser Glu Asp Tyr Pro His Glu Thr Met Ala Pro Asp Ile His 
1               5                   10                  15      


Glu Glu Arg Gln Tyr Arg Cys Glu Asp Cys Asp Gln Leu Phe Glu Ser 
            20                  25                  30          


Lys Ala Glu Leu Ala Asp His Gln Lys Phe Pro Cys Ser Thr Pro His 
        35                  40                  45              


Ser Ala Phe Ser Met Val Glu Glu Asp Phe Gln Gln Lys Leu Glu Ser 
    50                  55                  60                  


Glu Asn Asp Leu Gln Glu Ile His Thr Ile Gln Glu Cys Lys Glu Cys 
65                  70                  75                  80  


Asp Gln Val Phe Pro Asp Leu Gln Ser Leu Glu Lys His Met Leu Ser 
                85                  90                  95      


His Thr Glu Glu Arg Glu Tyr Lys Cys Asp Gln Cys Pro Lys Ala Phe 
            100                 105                 110         


Asn Trp Lys Ser Asn Leu Ile Arg His Gln Met Ser His Asp Ser Gly 
        115                 120                 125             


Lys His Tyr Glu Cys Glu Asn Cys Ala Lys Val Phe Thr Asp Pro Ser 
    130                 135                 140                 


Asn Leu Gln Arg His Ile Arg Ser Gln His Val Gly Ala Arg Ala His 
145                 150                 155                 160 


Ala Cys Pro Glu Cys Gly Lys Thr Phe Ala Thr Ser Ser Gly Leu Lys 
                165                 170                 175     


Gln His Lys His Ile His Ser Ser Val Lys Pro Phe Ile Cys Glu Val 
            180                 185                 190         


Cys His Lys Ser Tyr Thr Gln Phe Ser Asn Leu Cys Arg His Lys Arg 
        195                 200                 205             


Met His Ala Asp Cys Arg Thr Gln Ile Lys Cys Lys Asp Cys Gly Gln 
    210                 215                 220                 


Met Phe Ser Thr Thr Ser Ser Leu Asn Lys His Arg Arg Phe Cys Glu 
225                 230                 235                 240 


Gly Lys Asn His Phe Ala Ala Gly Gly Phe Phe Gly Gln Gly Ile Ser 
                245                 250                 255     


Leu Pro Gly Thr Pro Ala Met Asp Lys Thr Ser Met Val Asn Met Ser 
            260                 265                 270         


His Ala Asn Pro Gly Leu Ala Asp Tyr Phe Gly Ala Asn Arg His Pro 
        275                 280                 285             


Ala Gly Leu Thr Phe Pro Thr Ala Pro Gly Phe Ser Phe Ser Phe Pro 
    290                 295                 300                 


Gly Leu Phe Pro Ser Gly Leu Tyr His Arg Pro Pro Leu Ile Pro Ala 
305                 310                 315                 320 


Ser Ser Pro Val Lys Gly Leu Ser Ser Thr Glu Gln Thr Asn Lys Ser 
                325                 330                 335     


Gln Ser Pro Leu Met Thr His Pro Gln Ile Leu Pro Ala Thr Gln Asp 
            340                 345                 350         


Ile Leu Lys Ala Leu Ser Lys His Pro Ser Val Gly Asp Asn Lys Pro 
        355                 360                 365             


Val Glu Leu Gln Pro Glu Arg Ser Ser Glu Glu Arg Pro Phe Glu Lys 
    370                 375                 380                 


Ile Ser Asp Gln Ser Glu Ser Ser Asp Leu Asp Asp Val Ser Thr Pro 
385                 390                 395                 400 


Ser Gly Ser Asp Leu Glu Thr Thr Ser Gly Ser Asp Leu Glu Ser Asp 
                405                 410                 415     


Ile Glu Ser Asp Lys Glu Lys Phe Lys Glu Asn Gly Lys Met Phe Lys 
            420                 425                 430         


Asp Lys Val Ser Pro Leu Gln Asn Leu Ala Ser Ile Asn Asn Lys Lys 
        435                 440                 445             


Glu Tyr Ser Asn His Ser Ile Phe Ser Pro Ser Leu Glu Glu Gln Thr 
    450                 455                 460                 


Ala Val Ser Gly Ala Val Asn Asp Ser Ile Lys Ala Ile Ala Ser Ile 
465                 470                 475                 480 


Ala Glu Lys Tyr Phe Gly Ser Thr Gly Leu Val Gly Leu Gln Asp Lys 
                485                 490                 495     


Lys Val Gly Ala Leu Pro Tyr Pro Ser Met Phe Pro Leu Pro Phe Phe 
            500                 505                 510         


Pro Ala Phe Ser Gln Ser Met Tyr Pro Phe Pro Asp Arg Asp Leu Arg 
        515                 520                 525             


Ser Leu Pro Leu Lys Met Glu Pro Gln Ser Pro Gly Glu Val Lys Lys 
    530                 535                 540                 


Leu Gln Lys Gly Ser Ser Glu Ser Pro Phe Asp Leu Thr Thr Lys Arg 
545                 550                 555                 560 


Lys Asp Glu Lys Pro Leu Thr Pro Val Pro Ser Lys Pro Pro Val Thr 
                565                 570                 575     


Pro Ala Thr Ser Gln Asp Gln Pro Leu Asp Leu Ser Met Gly Ser Arg 
            580                 585                 590         


Ser Arg Ala Ser Gly Thr Lys Leu Thr Glu Pro Arg Lys Asn His Val 
        595                 600                 605             


Phe Gly Gly Lys Lys Gly Ser Asn Val Glu Ser Arg Pro Ala Ser Asp 
    610                 615                 620                 


Gly Ser Leu Gln His Ala Arg Pro Thr Pro Phe Phe Met Asp Pro Ile 
625                 630                 635                 640 


Tyr Arg Val Glu Lys Arg Lys Leu Thr Asp Pro Leu Glu Ala Leu Lys 
                645                 650                 655     


Glu Lys Tyr Leu Arg Pro Ser Pro Gly Phe Leu Phe His Pro Gln Met 
            660                 665                 670         


Ser Ala Ile Glu Asn Met Ala Glu Lys Leu Glu Ser Phe Ser Ala Leu 
        675                 680                 685             


Lys Pro Glu Ala Ser Glu Leu Leu Gln Ser Val Pro Ser Met Phe Asn 
    690                 695                 700                 


Phe Arg Ala Pro Pro Asn Ala Leu Pro Glu Asn Leu Leu Arg Lys Gly 
705                 710                 715                 720 


Lys Glu Arg Tyr Thr Cys Arg Tyr Cys Gly Lys Ile Phe Pro Arg Ser 
                725                 730                 735     


Ala Asn Leu Thr Arg His Leu Arg Thr His Thr Gly Glu Gln Pro Tyr 
            740                 745                 750         


Arg Cys Lys Tyr Cys Asp Arg Ser Phe Ser Ile Ser Ser Asn Leu Gln 
        755                 760                 765             


Arg His Val Arg Asn Ile His Asn Lys Glu Lys Pro Phe Lys Cys His 
    770                 775                 780                 


Leu Cys Asp Arg Cys Phe Gly Gln Gln Thr Asn Leu Asp Arg His Leu 
785                 790                 795                 800 


Lys Lys His Glu Asn Gly Asn Met Ser Gly Thr Ala Thr Ser Ser Pro 
                805                 810                 815     


His Ser Glu Leu Glu Ser Thr Gly Ala Ile Leu Asp Asp Lys Glu Asp 
            820                 825                 830         


Ala Tyr Phe Thr Glu Ile Arg Asn Phe Ile Gly Asn Ser Asn His Gly 
        835                 840                 845             


Ser Gln Ser Pro Arg Asn Val Glu Glu Arg Met Asn Gly Ser His Phe 
    850                 855                 860                 


Lys Asp Glu Lys Ala Leu Val Thr Ser Gln Asn Ser Asp Leu Leu Asp 
865                 870                 875                 880 


Asp Glu Glu Val Glu Asp Glu Val Leu Leu Asp Glu Glu Asp Glu Asp 
                885                 890                 895     


Asn Asp Ile Thr Gly Lys Thr Gly Lys Glu Pro Val Thr Ser Asn Leu 
            900                 905                 910         


His Glu Gly Asn Pro Glu Asp Asp Tyr Glu Glu Thr Ser Ala Leu Glu 
        915                 920                 925             


Met Ser Cys Lys Thr Ser Pro Val Arg Tyr Lys Glu Glu Glu Tyr Lys 
    930                 935                 940                 


Ser Gly Leu Ser Ala Leu Asp His Ile Arg His Phe Thr Asp Ser Leu 
945                 950                 955                 960 


Lys Met Arg Lys Met Glu Asp Asn Gln Tyr Ser Glu Ala Glu Leu Ser 
                965                 970                 975     


Ser Phe Ser Thr Ser His Val Pro Glu Glu Leu Lys Gln Pro Leu His 
            980                 985                 990         


Arg Lys Ser Lys Ser Gln Ala Tyr  Ala Met Met Leu Ser  Leu Ser Asp 
        995                 1000                 1005             


Lys Glu  Ser Leu His Ser Thr  Ser His Ser Ser Ser  Asn Val Trp 
    1010                 1015                 1020             


His Ser  Met Ala Arg Ala Ala  Ala Glu Ser Ser Ala  Ile Gln Ser 
    1025                 1030                 1035             


Ile Ser  His Val 
    1040         


<210>  23
<211>  1601
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (174)..(686)

<400>  23
agggtagagt gagaagcacc agcaggcagt aacagccaac ccttagccat tgctaagggc       60

agagaactgg tggagccttt ctcttactcc caggacttca gcacctaaga cagctccaaa      120

acaaaccaga acagtcagct ccgggggagc acgactgggc gagaggcaca gaa atg         176
                                                           Met            
                                                           1              

gac acc aga aat aag gcc cag ctc ctt gtg ctc ctg act ctt ctc agt        224
Asp Thr Arg Asn Lys Ala Gln Leu Leu Val Leu Leu Thr Leu Leu Ser           
            5                   10                  15                    

gtg ctc ttc tca cag act tcg gca tgg cct ctt tac agg gca cct tct        272
Val Leu Phe Ser Gln Thr Ser Ala Trp Pro Leu Tyr Arg Ala Pro Ser           
        20                  25                  30                        

gct ctc agg ttg ggt gac aga ata ccc ttt gag gga gca aat gaa cct        320
Ala Leu Arg Leu Gly Asp Arg Ile Pro Phe Glu Gly Ala Asn Glu Pro           
    35                  40                  45                            

gat caa gtt tca tta aaa gaa gac att gac atg ttg caa aat gca tta        368
Asp Gln Val Ser Leu Lys Glu Asp Ile Asp Met Leu Gln Asn Ala Leu           
50                  55                  60                  65            

gct gaa aat gac aca ccc tat tat gat gta tcc aga aat gcc agg cat        416
Ala Glu Asn Asp Thr Pro Tyr Tyr Asp Val Ser Arg Asn Ala Arg His           
                70                  75                  80                

gct gat gga gtt ttc acc agt gac ttc agt aaa ctc ttg ggt caa ctt        464
Ala Asp Gly Val Phe Thr Ser Asp Phe Ser Lys Leu Leu Gly Gln Leu           
            85                  90                  95                    

tct gcc aaa aag tac ctt gag tct ctt atg gga aaa cgt gtt agc agt        512
Ser Ala Lys Lys Tyr Leu Glu Ser Leu Met Gly Lys Arg Val Ser Ser           
        100                 105                 110                       

aac atc tca gaa gac cct gta cca gtc aaa cgt cac tca gat gca gtc        560
Asn Ile Ser Glu Asp Pro Val Pro Val Lys Arg His Ser Asp Ala Val           
    115                 120                 125                           

ttc act gac aac tat acc cgc ctt aga aaa caa atg gct gta aag aaa        608
Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln Met Ala Val Lys Lys           
130                 135                 140                 145           

tat ttg aac tca att ctg aat gga aag agg agc agt gag gga gaa tct        656
Tyr Leu Asn Ser Ile Leu Asn Gly Lys Arg Ser Ser Glu Gly Glu Ser           
                150                 155                 160               

ccc gac ttt cca gaa gag tta gaa aaa tga tgaaaaagac ctttggagca          706
Pro Asp Phe Pro Glu Glu Leu Glu Lys                                       
            165                 170                                       

aagctgatga caacttccca gtgaattctt gaaggaaaat gatacgcaac ataattaaat      766

tttgagttct acataagtaa ttcaagaaaa caacttcaat atccaaacca aataaaaata      826

ttgtgttgtg aatgttgtga tgtattctag ctaatgtaat aactgtgaag tttacattgt      886

aaatagtatt tgagagttct aaattttgtc tttaactcat aaaaagcctg caatttcata      946

tgctgtatat cctttctaac aaaaaaatat atttaatgat aagtaaatgc taggttaatt     1006

ccaattatat gagacgtttt tggaagagta gtaatagagc aaaattgatg tgtttattta     1066

tagagtgtac ttaactattc aggagagtag aacagataat cagtgtgtct aaatttgaat     1126

gttaagcaga tggaatgctg tgttaaataa acctcaaaat gtctaagata gtaacaatga     1186

agataaaaag acattcttcc aaaaagattt tcagaaaata ttatgtgttt ccatatttta     1246

taggcaacct ttatttttaa tggtgtttta aaaaatctca aatttggatt gctaatcacc     1306

aaaggctctc tcctgatagt ctttcagtta aggagaacga cccctgcttc tgacactgaa     1366

acttcccttt ctgcttgtgt taagtatgtg taaaatgtga agtgaatgaa acactcagtt     1426

gttcaataat aaatattttt gccataatga ctcagaatat tgctttggtc atatgagctt     1486

ccttctgtga aagtacattt ggagacacaa ctatttttcc aaaataattt taagaaatca     1546

aagagagaaa ataaagacct tgcttatgat tgcagataaa aaaaaaaaaa aaaaa          1601


<210>  24
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asp Thr Arg Asn Lys Ala Gln Leu Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Val Leu Phe Ser Gln Thr Ser Ala Trp Pro Leu Tyr Arg Ala Pro 
            20                  25                  30          


Ser Ala Leu Arg Leu Gly Asp Arg Ile Pro Phe Glu Gly Ala Asn Glu 
        35                  40                  45              


Pro Asp Gln Val Ser Leu Lys Glu Asp Ile Asp Met Leu Gln Asn Ala 
    50                  55                  60                  


Leu Ala Glu Asn Asp Thr Pro Tyr Tyr Asp Val Ser Arg Asn Ala Arg 
65                  70                  75                  80  


His Ala Asp Gly Val Phe Thr Ser Asp Phe Ser Lys Leu Leu Gly Gln 
                85                  90                  95      


Leu Ser Ala Lys Lys Tyr Leu Glu Ser Leu Met Gly Lys Arg Val Ser 
            100                 105                 110         


Ser Asn Ile Ser Glu Asp Pro Val Pro Val Lys Arg His Ser Asp Ala 
        115                 120                 125             


Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln Met Ala Val Lys 
    130                 135                 140                 


Lys Tyr Leu Asn Ser Ile Leu Asn Gly Lys Arg Ser Ser Glu Gly Glu 
145                 150                 155                 160 


Ser Pro Asp Phe Pro Glu Glu Leu Glu Lys 
                165                 170 


<210>  25
<211>  5132
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (28)..(4848)

<400>  25
gcgccgcgct gcgcaccgcc gccgacc atg agc gag gac agc cgc gga gac agc       54
                              Met Ser Glu Asp Ser Arg Gly Asp Ser         
                              1               5                           

cgc gcc gag agc gcc aag gac ctg gag aag cag ctt cgc ctg cgc gtg        102
Arg Ala Glu Ser Ala Lys Asp Leu Glu Lys Gln Leu Arg Leu Arg Val           
10                  15                  20                  25            

tgc gtg ctc agc gag ctc cag aag acc gag cgg gac tat gtg ggc acg        150
Cys Val Leu Ser Glu Leu Gln Lys Thr Glu Arg Asp Tyr Val Gly Thr           
                30                  35                  40                

ctg gag ttc ctg gtg tcg gca ttc tta cac aga atg aac cag tgt gca        198
Leu Glu Phe Leu Val Ser Ala Phe Leu His Arg Met Asn Gln Cys Ala           
            45                  50                  55                    

gca tca aaa gtt gac aaa aat gtg aca gaa gaa aca gtg aag atg ttg        246
Ala Ser Lys Val Asp Lys Asn Val Thr Glu Glu Thr Val Lys Met Leu           
        60                  65                  70                        

ttc tca aac att gaa gac atc ctt gca gta cat aaa gaa ttc tta aaa        294
Phe Ser Asn Ile Glu Asp Ile Leu Ala Val His Lys Glu Phe Leu Lys           
    75                  80                  85                            

gtc gtg gaa gaa tgc tta cac ccc gaa cct aat gct caa caa gaa gtg        342
Val Val Glu Glu Cys Leu His Pro Glu Pro Asn Ala Gln Gln Glu Val           
90                  95                  100                 105           

gga acc tgc ttt ctt cac ttt aaa gac aag ttt cgt atc tat gat gaa        390
Gly Thr Cys Phe Leu His Phe Lys Asp Lys Phe Arg Ile Tyr Asp Glu           
                110                 115                 120               

tat tgt agt aac cat gag aag gca caa aaa tta ctt ctt gaa ctc aac        438
Tyr Cys Ser Asn His Glu Lys Ala Gln Lys Leu Leu Leu Glu Leu Asn           
            125                 130                 135                   

aaa ata aga aca atc cgg aca ttt ctt ttg aac tgc atg ctg ctt gga        486
Lys Ile Arg Thr Ile Arg Thr Phe Leu Leu Asn Cys Met Leu Leu Gly           
        140                 145                 150                       

gga cgg aag aac aca gat gtt ccc ttg gaa gga tat tta gta aca cca        534
Gly Arg Lys Asn Thr Asp Val Pro Leu Glu Gly Tyr Leu Val Thr Pro           
    155                 160                 165                           

ata caa aga ata tgc aag tac cct ctt att ttg aag gag ttg ctg aag        582
Ile Gln Arg Ile Cys Lys Tyr Pro Leu Ile Leu Lys Glu Leu Leu Lys           
170                 175                 180                 185           

cgg act cca cgg aaa cac agt gac tat gca gca gtg atg gaa gcc ctc        630
Arg Thr Pro Arg Lys His Ser Asp Tyr Ala Ala Val Met Glu Ala Leu           
                190                 195                 200               

caa gcc atg aaa gct gtc tgt tcc aac ata aac gag gcc aag aga cag        678
Gln Ala Met Lys Ala Val Cys Ser Asn Ile Asn Glu Ala Lys Arg Gln           
            205                 210                 215                   

atg gag aag tta gaa gtt tta gag gaa tgg cag tct cac att gaa ggc        726
Met Glu Lys Leu Glu Val Leu Glu Glu Trp Gln Ser His Ile Glu Gly           
        220                 225                 230                       

tgg gag ggg tcc aac atc act gac acc tgc act gaa atg cta atg tgt        774
Trp Glu Gly Ser Asn Ile Thr Asp Thr Cys Thr Glu Met Leu Met Cys           
    235                 240                 245                           

gga gtc tta ctg aaa att tct tct gga aat att caa gaa cgg gtg ttt        822
Gly Val Leu Leu Lys Ile Ser Ser Gly Asn Ile Gln Glu Arg Val Phe           
250                 255                 260                 265           

ttt ctt ttc gat aat ctt ttg gtg tac tgc aaa aga aaa cac aga cgg        870
Phe Leu Phe Asp Asn Leu Leu Val Tyr Cys Lys Arg Lys His Arg Arg           
                270                 275                 280               

ttg aag aac agc aag gca tct aca gat gga cat cgg tac ctt ttt cgt        918
Leu Lys Asn Ser Lys Ala Ser Thr Asp Gly His Arg Tyr Leu Phe Arg           
            285                 290                 295                   

ggc cgg atc aac acg gag gtg atg gaa gtg gag aat gtg gat gat ggc        966
Gly Arg Ile Asn Thr Glu Val Met Glu Val Glu Asn Val Asp Asp Gly           
        300                 305                 310                       

acc gct gat ttc cat agc agt gga cac att gtt gtt aat gga tgg aag       1014
Thr Ala Asp Phe His Ser Ser Gly His Ile Val Val Asn Gly Trp Lys           
    315                 320                 325                           

ata cat aac aca gca aaa aat aaa tgg ttt gtt tgt atg gca aaa aca       1062
Ile His Asn Thr Ala Lys Asn Lys Trp Phe Val Cys Met Ala Lys Thr           
330                 335                 340                 345           

cct gaa gag aag cat gaa tgg ttt gaa gct att ttg aaa gaa aga gaa       1110
Pro Glu Glu Lys His Glu Trp Phe Glu Ala Ile Leu Lys Glu Arg Glu           
                350                 355                 360               

cgg cgg aaa ggt tta aaa tta gga atg gag caa gat acc tgg gtc atg       1158
Arg Arg Lys Gly Leu Lys Leu Gly Met Glu Gln Asp Thr Trp Val Met           
            365                 370                 375                   

atc tct gaa cag ggt gag aaa ctt tat aaa atg atg tgc aga caa gga       1206
Ile Ser Glu Gln Gly Glu Lys Leu Tyr Lys Met Met Cys Arg Gln Gly           
        380                 385                 390                       

aat ctg atc aaa gac cga aag aga aaa ctg act acg ttc cct aaa tgc       1254
Asn Leu Ile Lys Asp Arg Lys Arg Lys Leu Thr Thr Phe Pro Lys Cys           
    395                 400                 405                           

ttt ctt gga agc gaa ttt gtg tca tgg ctg ttg gaa att gga gag att       1302
Phe Leu Gly Ser Glu Phe Val Ser Trp Leu Leu Glu Ile Gly Glu Ile           
410                 415                 420                 425           

cac agg cct gag gaa ggc gtg cac ttg gga caa gca tta tta gaa aat       1350
His Arg Pro Glu Glu Gly Val His Leu Gly Gln Ala Leu Leu Glu Asn           
                430                 435                 440               

gga atc att cac cat gtt act gat aaa cat caa ttc aaa cca gaa cag       1398
Gly Ile Ile His His Val Thr Asp Lys His Gln Phe Lys Pro Glu Gln           
            445                 450                 455                   

atg tta tat aga ttt cgc tat gat gat gga aca ttt tat cca aga aat       1446
Met Leu Tyr Arg Phe Arg Tyr Asp Asp Gly Thr Phe Tyr Pro Arg Asn           
        460                 465                 470                       

gag atg cag gac gtg att tca aag ggt gta aga tta tat tgt cgt ctt       1494
Glu Met Gln Asp Val Ile Ser Lys Gly Val Arg Leu Tyr Cys Arg Leu           
    475                 480                 485                           

cat agc ctt ttt act cca gtg ata aga gat aaa gat tac cat tta agg       1542
His Ser Leu Phe Thr Pro Val Ile Arg Asp Lys Asp Tyr His Leu Arg           
490                 495                 500                 505           

acc tac aaa tct gtg gtc atg gcc aac aaa ctg ata gac tgg tta att       1590
Thr Tyr Lys Ser Val Val Met Ala Asn Lys Leu Ile Asp Trp Leu Ile           
                510                 515                 520               

gca cag gga gat tgc cgc acc aga gaa gag gca atg ata ttt ggc gtt       1638
Ala Gln Gly Asp Cys Arg Thr Arg Glu Glu Ala Met Ile Phe Gly Val           
            525                 530                 535                   

gga ctc tgt gac aat gga ttt atg cac cat gtc ctt gaa aaa agc gaa       1686
Gly Leu Cys Asp Asn Gly Phe Met His His Val Leu Glu Lys Ser Glu           
        540                 545                 550                       

ttc aaa gat gaa ccc cta ctt ttc cgt ttt ttt tcg gat gag gaa atg       1734
Phe Lys Asp Glu Pro Leu Leu Phe Arg Phe Phe Ser Asp Glu Glu Met           
    555                 560                 565                           

gag gga tca aat atg aaa cat cga ctt atg aaa cat gac tta aaa gtt       1782
Glu Gly Ser Asn Met Lys His Arg Leu Met Lys His Asp Leu Lys Val           
570                 575                 580                 585           

gtg gaa aat gtt ata gct aag tca tta ttg att aaa tcc aat gaa ggc       1830
Val Glu Asn Val Ile Ala Lys Ser Leu Leu Ile Lys Ser Asn Glu Gly           
                590                 595                 600               

agc tat ggc ttt gga tta gaa gac aaa aat aaa gtt cca ata ata aag       1878
Ser Tyr Gly Phe Gly Leu Glu Asp Lys Asn Lys Val Pro Ile Ile Lys           
            605                 610                 615                   

ttg gta gaa aag gga tct aat gct gag atg gct ggc atg gaa gtc ggg       1926
Leu Val Glu Lys Gly Ser Asn Ala Glu Met Ala Gly Met Glu Val Gly           
        620                 625                 630                       

aaa aag att ttt gct att aat ggt gac cta gtt ttt atg aga cct ttc       1974
Lys Lys Ile Phe Ala Ile Asn Gly Asp Leu Val Phe Met Arg Pro Phe           
    635                 640                 645                           

aat gaa gtg gat tgc ttc ctg aaa tcg tgt tta aac agc aga aaa cct       2022
Asn Glu Val Asp Cys Phe Leu Lys Ser Cys Leu Asn Ser Arg Lys Pro           
650                 655                 660                 665           

cta aga gtt ctt gtg agc aca aag cca aga gag aca gtg aaa att cca       2070
Leu Arg Val Leu Val Ser Thr Lys Pro Arg Glu Thr Val Lys Ile Pro           
                670                 675                 680               

gat tca gct gat gga ctt ggc ttc cag atc cgg gga ttt ggc cct tct       2118
Asp Ser Ala Asp Gly Leu Gly Phe Gln Ile Arg Gly Phe Gly Pro Ser           
            685                 690                 695                   

gtt gtg cat gct gta gga aga gga act gtg gct gca gca gct ggt ctt       2166
Val Val His Ala Val Gly Arg Gly Thr Val Ala Ala Ala Ala Gly Leu           
        700                 705                 710                       

cac cct gga cag tgc att atc aag gtg aat gga atc aat gtc agc aaa       2214
His Pro Gly Gln Cys Ile Ile Lys Val Asn Gly Ile Asn Val Ser Lys           
    715                 720                 725                           

gag aca cat gcc agt gtc att gca cac gtt aca gcc tgc agg aag tac       2262
Glu Thr His Ala Ser Val Ile Ala His Val Thr Ala Cys Arg Lys Tyr           
730                 735                 740                 745           

agg cgg cca acg aag caa gat tcc ata caa tgg gtt tat aat agc att       2310
Arg Arg Pro Thr Lys Gln Asp Ser Ile Gln Trp Val Tyr Asn Ser Ile           
                750                 755                 760               

gag agt gct caa gaa gac ctt caa aaa tct cac tcc aag ccc cct gga       2358
Glu Ser Ala Gln Glu Asp Leu Gln Lys Ser His Ser Lys Pro Pro Gly           
            765                 770                 775                   

gat gaa gca ggg gat gct ttt gac tgt aaa gta gaa gag gtt att gac       2406
Asp Glu Ala Gly Asp Ala Phe Asp Cys Lys Val Glu Glu Val Ile Asp           
        780                 785                 790                       

aaa ttc aac act atg gcc atc att gat ggg aag aag gag cat gtg agt       2454
Lys Phe Asn Thr Met Ala Ile Ile Asp Gly Lys Lys Glu His Val Ser           
    795                 800                 805                           

ctg aca gtg gac aat gtc cac ctg gaa tat ggt gtc gtg tat gag tac       2502
Leu Thr Val Asp Asn Val His Leu Glu Tyr Gly Val Val Tyr Glu Tyr           
810                 815                 820                 825           

gac agc aca gct ggc atc aag tgc aat gtg gtg gaa aag atg att gag       2550
Asp Ser Thr Ala Gly Ile Lys Cys Asn Val Val Glu Lys Met Ile Glu           
                830                 835                 840               

ccc aaa ggt ttc ttc agc tta act gcc aag att ctt gaa gcc ctg gct       2598
Pro Lys Gly Phe Phe Ser Leu Thr Ala Lys Ile Leu Glu Ala Leu Ala           
            845                 850                 855                   

aaa agt gat gag cat ttt gta caa aac tgt acc agc cta aat tct cta       2646
Lys Ser Asp Glu His Phe Val Gln Asn Cys Thr Ser Leu Asn Ser Leu           
        860                 865                 870                       

aat gaa gtg att cct act gac ctt cag agt aaa ttc agt gcc ctt tgc       2694
Asn Glu Val Ile Pro Thr Asp Leu Gln Ser Lys Phe Ser Ala Leu Cys           
    875                 880                 885                           

agt gaa aga att gaa cac cta tgt cag aga ata tcc agt tat aaa aag       2742
Ser Glu Arg Ile Glu His Leu Cys Gln Arg Ile Ser Ser Tyr Lys Lys           
890                 895                 900                 905           

ttt tct cgt gta ctg aag aat agg gcc tgg cct act ttt aaa cag gcc       2790
Phe Ser Arg Val Leu Lys Asn Arg Ala Trp Pro Thr Phe Lys Gln Ala           
                910                 915                 920               

aaa tct aaa atc tcc cca ctg cac agc agt gat ttc tgc cct acc aac       2838
Lys Ser Lys Ile Ser Pro Leu His Ser Ser Asp Phe Cys Pro Thr Asn           
            925                 930                 935                   

tgc cat gtc aat gtg atg gaa gtt tct tat ccc aaa aca tca acc tct       2886
Cys His Val Asn Val Met Glu Val Ser Tyr Pro Lys Thr Ser Thr Ser           
        940                 945                 950                       

ttg gga agt gca ttt ggt gtt cag ttg gat agc agg aag cat aat tct       2934
Leu Gly Ser Ala Phe Gly Val Gln Leu Asp Ser Arg Lys His Asn Ser           
    955                 960                 965                           

cat gat aaa gaa aac aaa tct tcg gag caa ggg aaa ctg agc cct atg       2982
His Asp Lys Glu Asn Lys Ser Ser Glu Gln Gly Lys Leu Ser Pro Met           
970                 975                 980                 985           

gtg tac att cag cac acc atc aca acc atg gcg gcc cct tca ggt  ctg      3030
Val Tyr Ile Gln His Thr Ile Thr Thr Met Ala Ala Pro Ser Gly  Leu          
                990                 995                 1000              

tct ctg gga cag  cag gat ggc cat ggt  ctc agg tat ctg cta  aaa        3075
Ser Leu Gly Gln  Gln Asp Gly His Gly  Leu Arg Tyr Leu Leu  Lys            
            1005                 1010                 1015                

gaa gaa gac tta  gaa acc caa gac atc  tat cag aaa ctg ctg  ggc        3120
Glu Glu Asp Leu  Glu Thr Gln Asp Ile  Tyr Gln Lys Leu Leu  Gly            
            1020                 1025                 1030                

aaa ctt cag act  gca ctg aaa gag gtg  gag atg tgt gtt tgt  caa        3165
Lys Leu Gln Thr  Ala Leu Lys Glu Val  Glu Met Cys Val Cys  Gln            
            1035                 1040                 1045                

ata gat gac ctt  ctg tct tca ata aca  tat tct cct aaa tta  gaa        3210
Ile Asp Asp Leu  Leu Ser Ser Ile Thr  Tyr Ser Pro Lys Leu  Glu            
            1050                 1055                 1060                

cgt aag aca tca  gag ggc ata ata cca  aca gac agt gac aat  gag        3255
Arg Lys Thr Ser  Glu Gly Ile Ile Pro  Thr Asp Ser Asp Asn  Glu            
            1065                 1070                 1075                

aag gga gaa aga  aac agc aaa cgg gta  tgt ttt aat gta gca  gga        3300
Lys Gly Glu Arg  Asn Ser Lys Arg Val  Cys Phe Asn Val Ala  Gly            
            1080                 1085                 1090                

gat gaa cag gaa  gat tct ggt cat gac  acc atc agc aac aga  gac        3345
Asp Glu Gln Glu  Asp Ser Gly His Asp  Thr Ile Ser Asn Arg  Asp            
            1095                 1100                 1105                

tct tac agt gac  tgc aac agc aat agg  aat tcc atc gcc tcc  ttc        3390
Ser Tyr Ser Asp  Cys Asn Ser Asn Arg  Asn Ser Ile Ala Ser  Phe            
            1110                 1115                 1120                

acc agc atc tgc  agc agc cag tgc agc  tcg tat ttc cac agt  gat        3435
Thr Ser Ile Cys  Ser Ser Gln Cys Ser  Ser Tyr Phe His Ser  Asp            
            1125                 1130                 1135                

gaa atg gac tca  ggt gat gaa ctt ccc  tta agt gtt cgc ata  tct        3480
Glu Met Asp Ser  Gly Asp Glu Leu Pro  Leu Ser Val Arg Ile  Ser            
            1140                 1145                 1150                

cat gat aaa cag  gac aag ata cat agt  tgc ctt gag cat ctt  ttc        3525
His Asp Lys Gln  Asp Lys Ile His Ser  Cys Leu Glu His Leu  Phe            
            1155                 1160                 1165                

agc cag gtg gat  tca att acc aat ctc  cta aaa ggg cag gct  gtt        3570
Ser Gln Val Asp  Ser Ile Thr Asn Leu  Leu Lys Gly Gln Ala  Val            
            1170                 1175                 1180                

gtg agg gcc ttt  gac caa acc aag tat  ctc act cca ggc cga  gga        3615
Val Arg Ala Phe  Asp Gln Thr Lys Tyr  Leu Thr Pro Gly Arg  Gly            
            1185                 1190                 1195                

ttg caa gaa ttt  caa cag gaa atg gaa  cca aag ctg agt tgt  cca        3660
Leu Gln Glu Phe  Gln Gln Glu Met Glu  Pro Lys Leu Ser Cys  Pro            
            1200                 1205                 1210                

aaa agg cta cgg  ctt cat atc aag caa  gat cct tgg aat ctt  ccc        3705
Lys Arg Leu Arg  Leu His Ile Lys Gln  Asp Pro Trp Asn Leu  Pro            
            1215                 1220                 1225                

agc agc gtc cgg  act ctt gct cag aac  atc agg aaa ttt gtt  gaa        3750
Ser Ser Val Arg  Thr Leu Ala Gln Asn  Ile Arg Lys Phe Val  Glu            
            1230                 1235                 1240                

gag gta aag tgt  agg cta ctc ctg gct  ctt ctt gaa tat tca  gat        3795
Glu Val Lys Cys  Arg Leu Leu Leu Ala  Leu Leu Glu Tyr Ser  Asp            
            1245                 1250                 1255                

agt gag aca cag  ctc cgt aga gac atg  gtt ttc tgc cag act  ctt        3840
Ser Glu Thr Gln  Leu Arg Arg Asp Met  Val Phe Cys Gln Thr  Leu            
            1260                 1265                 1270                

gtg gcc act gtc  tgt gcc ttc tct gag  cag ctc atg gcg gcc  ttg        3885
Val Ala Thr Val  Cys Ala Phe Ser Glu  Gln Leu Met Ala Ala  Leu            
            1275                 1280                 1285                

aac cag atg ttt  gac aac agc aag gaa  aat gag atg gaa act  tgg        3930
Asn Gln Met Phe  Asp Asn Ser Lys Glu  Asn Glu Met Glu Thr  Trp            
            1290                 1295                 1300                

gaa gcc agc agg  agg tgg ctg gac cag  ata gcg aat gca ggt  gtt        3975
Glu Ala Ser Arg  Arg Trp Leu Asp Gln  Ile Ala Asn Ala Gly  Val            
            1305                 1310                 1315                

ctt ttt cac ttt  cag tca ctt ctg tca  cca aac ttg aca gat  gaa        4020
Leu Phe His Phe  Gln Ser Leu Leu Ser  Pro Asn Leu Thr Asp  Glu            
            1320                 1325                 1330                

caa gcc atg tta  gaa gat aca ctg gtt  gca cta ttt gat ttg  gaa        4065
Gln Ala Met Leu  Glu Asp Thr Leu Val  Ala Leu Phe Asp Leu  Glu            
            1335                 1340                 1345                

aag gtt tcc ttt  tac ttt aaa cca tca  gaa gag gaa cct ctg  gtt        4110
Lys Val Ser Phe  Tyr Phe Lys Pro Ser  Glu Glu Glu Pro Leu  Val            
            1350                 1355                 1360                

gca aat gtt cct  ctt aca tat caa gca  gaa gga agt cgg caa  gct        4155
Ala Asn Val Pro  Leu Thr Tyr Gln Ala  Glu Gly Ser Arg Gln  Ala            
            1365                 1370                 1375                

ctg aaa gtt tac  ttc tac att gat agt  tat cat ttt gaa caa  ctt        4200
Leu Lys Val Tyr  Phe Tyr Ile Asp Ser  Tyr His Phe Glu Gln  Leu            
            1380                 1385                 1390                

cct caa cgg ctg  aaa aat gga gga ggg  ttt aaa att cat cct  gtt        4245
Pro Gln Arg Leu  Lys Asn Gly Gly Gly  Phe Lys Ile His Pro  Val            
            1395                 1400                 1405                

ctt ttt gca caa  gca cta gag agc atg  gaa gga tat tat tac  aga        4290
Leu Phe Ala Gln  Ala Leu Glu Ser Met  Glu Gly Tyr Tyr Tyr  Arg            
            1410                 1415                 1420                

gac aat gtt tct  gtg gaa gaa ttt caa  gct cag ata aat gca  gcc        4335
Asp Asn Val Ser  Val Glu Glu Phe Gln  Ala Gln Ile Asn Ala  Ala            
            1425                 1430                 1435                

tca ctg gaa aag  gtc aaa cag tac aac  cag aag ctc agg gca  ttc        4380
Ser Leu Glu Lys  Val Lys Gln Tyr Asn  Gln Lys Leu Arg Ala  Phe            
            1440                 1445                 1450                

tac ttg gac aag  tca aat tca cca cca  aac tcc aca tcc aaa  gct        4425
Tyr Leu Asp Lys  Ser Asn Ser Pro Pro  Asn Ser Thr Ser Lys  Ala            
            1455                 1460                 1465                

gcc tat gta gat  aag cta atg agg cct  ctc aac gct ttg gat  gaa        4470
Ala Tyr Val Asp  Lys Leu Met Arg Pro  Leu Asn Ala Leu Asp  Glu            
            1470                 1475                 1480                

ctt tac cga ctg  gta gcc tcg ttt atc  aga tcc aag cgc aca  gct        4515
Leu Tyr Arg Leu  Val Ala Ser Phe Ile  Arg Ser Lys Arg Thr  Ala            
            1485                 1490                 1495                

gcc tgt gca aac  aca gct tgc agt gct  tct ggg gtt gga ctg  ctg        4560
Ala Cys Ala Asn  Thr Ala Cys Ser Ala  Ser Gly Val Gly Leu  Leu            
            1500                 1505                 1510                

tca gtt tcc tcg  gag ctg tgc aac agg  ctg ggc gcc tgc cac  atc        4605
Ser Val Ser Ser  Glu Leu Cys Asn Arg  Leu Gly Ala Cys His  Ile            
            1515                 1520                 1525                

atc atg tgc agc  agc ggt gtg cat cgg  tgc acc ctg agc gtg  acg        4650
Ile Met Cys Ser  Ser Gly Val His Arg  Cys Thr Leu Ser Val  Thr            
            1530                 1535                 1540                

ctg gag caa gcc  atc att ctg gcc aga  agc cac gga ctg cca  cct        4695
Leu Glu Gln Ala  Ile Ile Leu Ala Arg  Ser His Gly Leu Pro  Pro            
            1545                 1550                 1555                

cgt tac atc atg  cag gct aca gat gtg  atg cgg aag cag gga  gca        4740
Arg Tyr Ile Met  Gln Ala Thr Asp Val  Met Arg Lys Gln Gly  Ala            
            1560                 1565                 1570                

aga gtt cag aac  aca gcg aag aat ttg  gga gtc aga gac cgg  act        4785
Arg Val Gln Asn  Thr Ala Lys Asn Leu  Gly Val Arg Asp Arg  Thr            
            1575                 1580                 1585                

cca cag tct gca  cca agg ctg tac aag  ctg tgc gag cca cct  ccc        4830
Pro Gln Ser Ala  Pro Arg Leu Tyr Lys  Leu Cys Glu Pro Pro  Pro            
            1590                 1595                 1600                

cca gct gga gaa  gaa tga aaagaactcc caagaaacca ggcaggcaga             4878
Pro Ala Gly Glu  Glu                                                      
            1605                                                          

agctcctgaa tgctggacta gacaaactac atgctggcta aacattctcc actgaagata     4938

catcaatgct tttttttttt tttttttctg taaatctttc ttcccattgc aaacaagtag     4998

tgatcagttt atactttgat atttatgctg gaaatggata gaagttcaat cagacagttc     5058

agcttcacga actgatgtct ctctgtattg acattaagta ttcactttta gagtaaaatc     5118

catccctggg acat                                                       5132


<210>  26
<211>  1606
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Glu Asp Ser Arg Gly Asp Ser Arg Ala Glu Ser Ala Lys Asp 
1               5                   10                  15      


Leu Glu Lys Gln Leu Arg Leu Arg Val Cys Val Leu Ser Glu Leu Gln 
            20                  25                  30          


Lys Thr Glu Arg Asp Tyr Val Gly Thr Leu Glu Phe Leu Val Ser Ala 
        35                  40                  45              


Phe Leu His Arg Met Asn Gln Cys Ala Ala Ser Lys Val Asp Lys Asn 
    50                  55                  60                  


Val Thr Glu Glu Thr Val Lys Met Leu Phe Ser Asn Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Ala Val His Lys Glu Phe Leu Lys Val Val Glu Glu Cys Leu His 
                85                  90                  95      


Pro Glu Pro Asn Ala Gln Gln Glu Val Gly Thr Cys Phe Leu His Phe 
            100                 105                 110         


Lys Asp Lys Phe Arg Ile Tyr Asp Glu Tyr Cys Ser Asn His Glu Lys 
        115                 120                 125             


Ala Gln Lys Leu Leu Leu Glu Leu Asn Lys Ile Arg Thr Ile Arg Thr 
    130                 135                 140                 


Phe Leu Leu Asn Cys Met Leu Leu Gly Gly Arg Lys Asn Thr Asp Val 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Leu Val Thr Pro Ile Gln Arg Ile Cys Lys Tyr 
                165                 170                 175     


Pro Leu Ile Leu Lys Glu Leu Leu Lys Arg Thr Pro Arg Lys His Ser 
            180                 185                 190         


Asp Tyr Ala Ala Val Met Glu Ala Leu Gln Ala Met Lys Ala Val Cys 
        195                 200                 205             


Ser Asn Ile Asn Glu Ala Lys Arg Gln Met Glu Lys Leu Glu Val Leu 
    210                 215                 220                 


Glu Glu Trp Gln Ser His Ile Glu Gly Trp Glu Gly Ser Asn Ile Thr 
225                 230                 235                 240 


Asp Thr Cys Thr Glu Met Leu Met Cys Gly Val Leu Leu Lys Ile Ser 
                245                 250                 255     


Ser Gly Asn Ile Gln Glu Arg Val Phe Phe Leu Phe Asp Asn Leu Leu 
            260                 265                 270         


Val Tyr Cys Lys Arg Lys His Arg Arg Leu Lys Asn Ser Lys Ala Ser 
        275                 280                 285             


Thr Asp Gly His Arg Tyr Leu Phe Arg Gly Arg Ile Asn Thr Glu Val 
    290                 295                 300                 


Met Glu Val Glu Asn Val Asp Asp Gly Thr Ala Asp Phe His Ser Ser 
305                 310                 315                 320 


Gly His Ile Val Val Asn Gly Trp Lys Ile His Asn Thr Ala Lys Asn 
                325                 330                 335     


Lys Trp Phe Val Cys Met Ala Lys Thr Pro Glu Glu Lys His Glu Trp 
            340                 345                 350         


Phe Glu Ala Ile Leu Lys Glu Arg Glu Arg Arg Lys Gly Leu Lys Leu 
        355                 360                 365             


Gly Met Glu Gln Asp Thr Trp Val Met Ile Ser Glu Gln Gly Glu Lys 
    370                 375                 380                 


Leu Tyr Lys Met Met Cys Arg Gln Gly Asn Leu Ile Lys Asp Arg Lys 
385                 390                 395                 400 


Arg Lys Leu Thr Thr Phe Pro Lys Cys Phe Leu Gly Ser Glu Phe Val 
                405                 410                 415     


Ser Trp Leu Leu Glu Ile Gly Glu Ile His Arg Pro Glu Glu Gly Val 
            420                 425                 430         


His Leu Gly Gln Ala Leu Leu Glu Asn Gly Ile Ile His His Val Thr 
        435                 440                 445             


Asp Lys His Gln Phe Lys Pro Glu Gln Met Leu Tyr Arg Phe Arg Tyr 
    450                 455                 460                 


Asp Asp Gly Thr Phe Tyr Pro Arg Asn Glu Met Gln Asp Val Ile Ser 
465                 470                 475                 480 


Lys Gly Val Arg Leu Tyr Cys Arg Leu His Ser Leu Phe Thr Pro Val 
                485                 490                 495     


Ile Arg Asp Lys Asp Tyr His Leu Arg Thr Tyr Lys Ser Val Val Met 
            500                 505                 510         


Ala Asn Lys Leu Ile Asp Trp Leu Ile Ala Gln Gly Asp Cys Arg Thr 
        515                 520                 525             


Arg Glu Glu Ala Met Ile Phe Gly Val Gly Leu Cys Asp Asn Gly Phe 
    530                 535                 540                 


Met His His Val Leu Glu Lys Ser Glu Phe Lys Asp Glu Pro Leu Leu 
545                 550                 555                 560 


Phe Arg Phe Phe Ser Asp Glu Glu Met Glu Gly Ser Asn Met Lys His 
                565                 570                 575     


Arg Leu Met Lys His Asp Leu Lys Val Val Glu Asn Val Ile Ala Lys 
            580                 585                 590         


Ser Leu Leu Ile Lys Ser Asn Glu Gly Ser Tyr Gly Phe Gly Leu Glu 
        595                 600                 605             


Asp Lys Asn Lys Val Pro Ile Ile Lys Leu Val Glu Lys Gly Ser Asn 
    610                 615                 620                 


Ala Glu Met Ala Gly Met Glu Val Gly Lys Lys Ile Phe Ala Ile Asn 
625                 630                 635                 640 


Gly Asp Leu Val Phe Met Arg Pro Phe Asn Glu Val Asp Cys Phe Leu 
                645                 650                 655     


Lys Ser Cys Leu Asn Ser Arg Lys Pro Leu Arg Val Leu Val Ser Thr 
            660                 665                 670         


Lys Pro Arg Glu Thr Val Lys Ile Pro Asp Ser Ala Asp Gly Leu Gly 
        675                 680                 685             


Phe Gln Ile Arg Gly Phe Gly Pro Ser Val Val His Ala Val Gly Arg 
    690                 695                 700                 


Gly Thr Val Ala Ala Ala Ala Gly Leu His Pro Gly Gln Cys Ile Ile 
705                 710                 715                 720 


Lys Val Asn Gly Ile Asn Val Ser Lys Glu Thr His Ala Ser Val Ile 
                725                 730                 735     


Ala His Val Thr Ala Cys Arg Lys Tyr Arg Arg Pro Thr Lys Gln Asp 
            740                 745                 750         


Ser Ile Gln Trp Val Tyr Asn Ser Ile Glu Ser Ala Gln Glu Asp Leu 
        755                 760                 765             


Gln Lys Ser His Ser Lys Pro Pro Gly Asp Glu Ala Gly Asp Ala Phe 
    770                 775                 780                 


Asp Cys Lys Val Glu Glu Val Ile Asp Lys Phe Asn Thr Met Ala Ile 
785                 790                 795                 800 


Ile Asp Gly Lys Lys Glu His Val Ser Leu Thr Val Asp Asn Val His 
                805                 810                 815     


Leu Glu Tyr Gly Val Val Tyr Glu Tyr Asp Ser Thr Ala Gly Ile Lys 
            820                 825                 830         


Cys Asn Val Val Glu Lys Met Ile Glu Pro Lys Gly Phe Phe Ser Leu 
        835                 840                 845             


Thr Ala Lys Ile Leu Glu Ala Leu Ala Lys Ser Asp Glu His Phe Val 
    850                 855                 860                 


Gln Asn Cys Thr Ser Leu Asn Ser Leu Asn Glu Val Ile Pro Thr Asp 
865                 870                 875                 880 


Leu Gln Ser Lys Phe Ser Ala Leu Cys Ser Glu Arg Ile Glu His Leu 
                885                 890                 895     


Cys Gln Arg Ile Ser Ser Tyr Lys Lys Phe Ser Arg Val Leu Lys Asn 
            900                 905                 910         


Arg Ala Trp Pro Thr Phe Lys Gln Ala Lys Ser Lys Ile Ser Pro Leu 
        915                 920                 925             


His Ser Ser Asp Phe Cys Pro Thr Asn Cys His Val Asn Val Met Glu 
    930                 935                 940                 


Val Ser Tyr Pro Lys Thr Ser Thr Ser Leu Gly Ser Ala Phe Gly Val 
945                 950                 955                 960 


Gln Leu Asp Ser Arg Lys His Asn Ser His Asp Lys Glu Asn Lys Ser 
                965                 970                 975     


Ser Glu Gln Gly Lys Leu Ser Pro Met Val Tyr Ile Gln His Thr Ile 
            980                 985                 990         


Thr Thr Met Ala Ala Pro Ser Gly  Leu Ser Leu Gly Gln  Gln Asp Gly 
        995                 1000                 1005             


His Gly  Leu Arg Tyr Leu Leu  Lys Glu Glu Asp Leu  Glu Thr Gln 
    1010                 1015                 1020             


Asp Ile  Tyr Gln Lys Leu Leu  Gly Lys Leu Gln Thr  Ala Leu Lys 
    1025                 1030                 1035             


Glu Val  Glu Met Cys Val Cys  Gln Ile Asp Asp Leu  Leu Ser Ser 
    1040                 1045                 1050             


Ile Thr  Tyr Ser Pro Lys Leu  Glu Arg Lys Thr Ser  Glu Gly Ile 
    1055                 1060                 1065             


Ile Pro  Thr Asp Ser Asp Asn  Glu Lys Gly Glu Arg  Asn Ser Lys 
    1070                 1075                 1080             


Arg Val  Cys Phe Asn Val Ala  Gly Asp Glu Gln Glu  Asp Ser Gly 
    1085                 1090                 1095             


His Asp  Thr Ile Ser Asn Arg  Asp Ser Tyr Ser Asp  Cys Asn Ser 
    1100                 1105                 1110             


Asn Arg  Asn Ser Ile Ala Ser  Phe Thr Ser Ile Cys  Ser Ser Gln 
    1115                 1120                 1125             


Cys Ser  Ser Tyr Phe His Ser  Asp Glu Met Asp Ser  Gly Asp Glu 
    1130                 1135                 1140             


Leu Pro  Leu Ser Val Arg Ile  Ser His Asp Lys Gln  Asp Lys Ile 
    1145                 1150                 1155             


His Ser  Cys Leu Glu His Leu  Phe Ser Gln Val Asp  Ser Ile Thr 
    1160                 1165                 1170             


Asn Leu  Leu Lys Gly Gln Ala  Val Val Arg Ala Phe  Asp Gln Thr 
    1175                 1180                 1185             


Lys Tyr  Leu Thr Pro Gly Arg  Gly Leu Gln Glu Phe  Gln Gln Glu 
    1190                 1195                 1200             


Met Glu  Pro Lys Leu Ser Cys  Pro Lys Arg Leu Arg  Leu His Ile 
    1205                 1210                 1215             


Lys Gln  Asp Pro Trp Asn Leu  Pro Ser Ser Val Arg  Thr Leu Ala 
    1220                 1225                 1230             


Gln Asn  Ile Arg Lys Phe Val  Glu Glu Val Lys Cys  Arg Leu Leu 
    1235                 1240                 1245             


Leu Ala  Leu Leu Glu Tyr Ser  Asp Ser Glu Thr Gln  Leu Arg Arg 
    1250                 1255                 1260             


Asp Met  Val Phe Cys Gln Thr  Leu Val Ala Thr Val  Cys Ala Phe 
    1265                 1270                 1275             


Ser Glu  Gln Leu Met Ala Ala  Leu Asn Gln Met Phe  Asp Asn Ser 
    1280                 1285                 1290             


Lys Glu  Asn Glu Met Glu Thr  Trp Glu Ala Ser Arg  Arg Trp Leu 
    1295                 1300                 1305             


Asp Gln  Ile Ala Asn Ala Gly  Val Leu Phe His Phe  Gln Ser Leu 
    1310                 1315                 1320             


Leu Ser  Pro Asn Leu Thr Asp  Glu Gln Ala Met Leu  Glu Asp Thr 
    1325                 1330                 1335             


Leu Val  Ala Leu Phe Asp Leu  Glu Lys Val Ser Phe  Tyr Phe Lys 
    1340                 1345                 1350             


Pro Ser  Glu Glu Glu Pro Leu  Val Ala Asn Val Pro  Leu Thr Tyr 
    1355                 1360                 1365             


Gln Ala  Glu Gly Ser Arg Gln  Ala Leu Lys Val Tyr  Phe Tyr Ile 
    1370                 1375                 1380             


Asp Ser  Tyr His Phe Glu Gln  Leu Pro Gln Arg Leu  Lys Asn Gly 
    1385                 1390                 1395             


Gly Gly  Phe Lys Ile His Pro  Val Leu Phe Ala Gln  Ala Leu Glu 
    1400                 1405                 1410             


Ser Met  Glu Gly Tyr Tyr Tyr  Arg Asp Asn Val Ser  Val Glu Glu 
    1415                 1420                 1425             


Phe Gln  Ala Gln Ile Asn Ala  Ala Ser Leu Glu Lys  Val Lys Gln 
    1430                 1435                 1440             


Tyr Asn  Gln Lys Leu Arg Ala  Phe Tyr Leu Asp Lys  Ser Asn Ser 
    1445                 1450                 1455             


Pro Pro  Asn Ser Thr Ser Lys  Ala Ala Tyr Val Asp  Lys Leu Met 
    1460                 1465                 1470             


Arg Pro  Leu Asn Ala Leu Asp  Glu Leu Tyr Arg Leu  Val Ala Ser 
    1475                 1480                 1485             


Phe Ile  Arg Ser Lys Arg Thr  Ala Ala Cys Ala Asn  Thr Ala Cys 
    1490                 1495                 1500             


Ser Ala  Ser Gly Val Gly Leu  Leu Ser Val Ser Ser  Glu Leu Cys 
    1505                 1510                 1515             


Asn Arg  Leu Gly Ala Cys His  Ile Ile Met Cys Ser  Ser Gly Val 
    1520                 1525                 1530             


His Arg  Cys Thr Leu Ser Val  Thr Leu Glu Gln Ala  Ile Ile Leu 
    1535                 1540                 1545             


Ala Arg  Ser His Gly Leu Pro  Pro Arg Tyr Ile Met  Gln Ala Thr 
    1550                 1555                 1560             


Asp Val  Met Arg Lys Gln Gly  Ala Arg Val Gln Asn  Thr Ala Lys 
    1565                 1570                 1575             


Asn Leu  Gly Val Arg Asp Arg  Thr Pro Gln Ser Ala  Pro Arg Leu 
    1580                 1585                 1590             


Tyr Lys  Leu Cys Glu Pro Pro  Pro Pro Ala Gly Glu  Glu 
    1595                 1600                 1605     


<210>  27
<211>  3066
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (9)..(716)

<400>  27
ttcctttt atg cga aca caa gta tat gag ggg ttg tgt aaa aat tat ttt        50
         Met Arg Thr Gln Val Tyr Glu Gly Leu Cys Lys Asn Tyr Phe          
         1               5                   10                           

tct ctt gct gta cta caa aga gat aga atc aaa ctg ctt ttt ttc gac         98
Ser Leu Ala Val Leu Gln Arg Asp Arg Ile Lys Leu Leu Phe Phe Asp           
15                  20                  25                  30            

ata ctg gtt ttt ctt tct gtt ttt ctt ctc ttt ctt cta ttt ctt gtg        146
Ile Leu Val Phe Leu Ser Val Phe Leu Leu Phe Leu Leu Phe Leu Val           
                35                  40                  45                

gat att atg gct aat aac aca aca agt tta ggg agt cca tgg cca gaa        194
Asp Ile Met Ala Asn Asn Thr Thr Ser Leu Gly Ser Pro Trp Pro Glu           
            50                  55                  60                    

aac ttt tgg gag gac ctt atc atg tcc ttc act gta tcc atg gca atc        242
Asn Phe Trp Glu Asp Leu Ile Met Ser Phe Thr Val Ser Met Ala Ile           
        65                  70                  75                        

ggg ctg gta ctt gga gga ttt att tgg gct gtg ttc att tgt ctg tct        290
Gly Leu Val Leu Gly Gly Phe Ile Trp Ala Val Phe Ile Cys Leu Ser           
    80                  85                  90                            

cga aga aga aga gcc agt gct ccc atc tca cag tgg agt tca agc agg        338
Arg Arg Arg Arg Ala Ser Ala Pro Ile Ser Gln Trp Ser Ser Ser Arg           
95                  100                 105                 110           

aga tct agg tct tct tac acc cac ggc ctc aac aga act gga ttt tac        386
Arg Ser Arg Ser Ser Tyr Thr His Gly Leu Asn Arg Thr Gly Phe Tyr           
                115                 120                 125               

cgc cac agt ggc tgt gaa cgt cga agc aac ctc agc ctg gcc agt ctc        434
Arg His Ser Gly Cys Glu Arg Arg Ser Asn Leu Ser Leu Ala Ser Leu           
            130                 135                 140                   

acc ttc cag cga caa gct tcc ctg gaa caa gca aat tcc ttt cca aga        482
Thr Phe Gln Arg Gln Ala Ser Leu Glu Gln Ala Asn Ser Phe Pro Arg           
        145                 150                 155                       

aaa tca agt ttc aga gct tct act ttc cat ccc ttt ctg caa tgt cca        530
Lys Ser Ser Phe Arg Ala Ser Thr Phe His Pro Phe Leu Gln Cys Pro           
    160                 165                 170                           

cca ctt cct gtg gaa act gag agt cag ctg gtg act ctc cct tct tcc        578
Pro Leu Pro Val Glu Thr Glu Ser Gln Leu Val Thr Leu Pro Ser Ser           
175                 180                 185                 190           

aat atc tct ccc acc atc agc act tcc cac agt ctg agc cgt cct gac        626
Asn Ile Ser Pro Thr Ile Ser Thr Ser His Ser Leu Ser Arg Pro Asp           
                195                 200                 205               

tac tgg tcc agt aac agt ctt cga gtg ggc ctt tca aca ccg ccc cca        674
Tyr Trp Ser Ser Asn Ser Leu Arg Val Gly Leu Ser Thr Pro Pro Pro           
            210                 215                 220                   

cct gcc tat gag tcc atc atc aag gca ttc cca gat tcc tga                716
Pro Ala Tyr Glu Ser Ile Ile Lys Ala Phe Pro Asp Ser                       
        225                 230                 235                       

gtagggtggc ttttggtttt tgtttctttc ttgtcttgtc ttttattgaa aggaaatcaa      776

aaataggcta aacagaattt tgagggcatg gcccaaataa ctcatgagtt ccaagttgaa      836

acatggttgt gcaagttgga cattacaatg taaaacacat tttcttcaaa cacgttttcc      896

cttttgtttc aaaaaatgta atattttccc ccaagcgttt tatatttatg tattttgtat      956

tcaatgtgag gcttattaaa aatagtgatt ctaatgtaag aatcagctaa gatgcattat     1016

atatatttta attaaaatta aaacttcaga tatttgtgga ttacaatcct catttacttc     1076

caatgtgact aaaaagagaa aaaaaatcac tgtgtcactt taaagaaaaa tcttctaagg     1136

gatttggatt ttactttctt tagaatgaca agtgaatcat attgacattt tacaatctta     1196

gatttttctt tttttttctt ttgagacagg gtcttgatcc gtcgcccagg cgggagttgc     1256

agtagcatga tcaggactca ctgcagcctc tatctcccag gctcaagtaa tcctcccatc     1316

ttagtgcccc aagtagctgg gactacaggg gtgcactacc acaccgggtt gaattttttt     1376

ttaattttag tagagatgaa gtgtcactat gttaccaagg ctggtctcaa actcctaaac     1436

tcagatgatc ctcctgcctc ggcctcccaa agtgctggaa ttagcctggc caatcttgga     1496

tttttaatgg aatatgtggg cacaaaatga cagaacatag gacattctaa agttccttga     1556

tttgatcatt ataagaagtg tgggactcaa gcacaggaaa ctgaactctt ttggtgtcat     1616

tggatgtttc atttttgaca ctaatttttt ctggacaaac tctttatgtg tttttcccaa     1676

gaatagttat ctacttcctg gaggcaaaat ccttggattt actaacatga tgatttacct     1736

tttcttcacc gttgtcgtta cattgttaga aaagcaacag gaaaaaatcc aattcatttg     1796

acctaaaaac aagcctcaag tttaaaacca agctcacgtt tttcttaagg gaaaaatttt     1856

ctttcttaaa cttacatcta gcaacttgga aagcactttc tctggggatc ttcttttgta     1916

actttgcaga caaataagta tgagtcactg gggagagagt ttgttattga aatagatgtt     1976

gcccatgaag aattctcctt cctggattga ctcttaatca tcaggcatca ttcctggttt     2036

gcttctctac gaatctcaat tccaacttct ctgcagagtc tgtacagtga ttaagccatg     2096

ccagatggtc tttggtgcac acagttattt aagaatccac ttccacaggt ggctgccctt     2156

gtaaggaaga atgcatccct aaatgtggcc accagagagt tccagtgggc agatgtctgt     2216

ggctgccctt ctcatttaag gacatgagtt cactggagta ttactcaaaa agtctgtggt     2276

tcatttccag tattgtgaat atttagttta tgtggccgtt tctttgtttc tttgaacagt     2336

gggattttca gtgaaaaagt accctctttt tcatttccta ttgcagtggt cacagctaat     2396

agtgtctgaa catggttcaa gaataagaga ttccatgtag cattttcttt attattttca     2456

tttcccttat attatccatc attccttaag gacaattatt cttaataatg cttatagaaa     2516

atgttctcta attaaacatg ccaaaaggaa aaagtaagag aaagagggag caagaagaaa     2576

atggaagaaa aagggaaaaa agctaaccgg ataaccaatt tgttataagt tggttttcaa     2636

caaagaaatt tagcagccaa gtaaggtttc aagggaatat taacttggta tcagggctac     2696

tttttttttt ttttttttac ttgcatgtca tccttaatgt ctaacatgaa aaatcagcaa     2756

agagtatggt ttttatcaag aatttgtgtt gggagtaaaa actgctttat agctcccaaa     2816

ttaggaagag aagagcagaa atcctctggg gcatttaacc atctggcaga attgttgctg     2876

cacccttatc ccagttataa gacagtcaaa atgactattt cctaaatatt gtgagtgtat     2936

gaaatgtgaa attaaagcaa aaactggaga cttttaatgt atttctttaa tttgaaatgt     2996

tttgtggatt gtgaaataaa aataaattta tgtcaagttt tattcaaaaa aaaaaaaaaa     3056

aaaaaaaaaa                                                            3066


<210>  28
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Thr Gln Val Tyr Glu Gly Leu Cys Lys Asn Tyr Phe Ser Leu 
1               5                   10                  15      


Ala Val Leu Gln Arg Asp Arg Ile Lys Leu Leu Phe Phe Asp Ile Leu 
            20                  25                  30          


Val Phe Leu Ser Val Phe Leu Leu Phe Leu Leu Phe Leu Val Asp Ile 
        35                  40                  45              


Met Ala Asn Asn Thr Thr Ser Leu Gly Ser Pro Trp Pro Glu Asn Phe 
    50                  55                  60                  


Trp Glu Asp Leu Ile Met Ser Phe Thr Val Ser Met Ala Ile Gly Leu 
65                  70                  75                  80  


Val Leu Gly Gly Phe Ile Trp Ala Val Phe Ile Cys Leu Ser Arg Arg 
                85                  90                  95      


Arg Arg Ala Ser Ala Pro Ile Ser Gln Trp Ser Ser Ser Arg Arg Ser 
            100                 105                 110         


Arg Ser Ser Tyr Thr His Gly Leu Asn Arg Thr Gly Phe Tyr Arg His 
        115                 120                 125             


Ser Gly Cys Glu Arg Arg Ser Asn Leu Ser Leu Ala Ser Leu Thr Phe 
    130                 135                 140                 


Gln Arg Gln Ala Ser Leu Glu Gln Ala Asn Ser Phe Pro Arg Lys Ser 
145                 150                 155                 160 


Ser Phe Arg Ala Ser Thr Phe His Pro Phe Leu Gln Cys Pro Pro Leu 
                165                 170                 175     


Pro Val Glu Thr Glu Ser Gln Leu Val Thr Leu Pro Ser Ser Asn Ile 
            180                 185                 190         


Ser Pro Thr Ile Ser Thr Ser His Ser Leu Ser Arg Pro Asp Tyr Trp 
        195                 200                 205             


Ser Ser Asn Ser Leu Arg Val Gly Leu Ser Thr Pro Pro Pro Pro Ala 
    210                 215                 220                 


Tyr Glu Ser Ile Ile Lys Ala Phe Pro Asp Ser 
225                 230                 235 


<210>  29
<211>  831
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (18)..(761)

<400>  29
aggcacactc taccacc atg aat cca ctc ctg atc ctt acc ttt gtg gca          50
                   Met Asn Pro Leu Leu Ile Leu Thr Phe Val Ala            
                   1               5                   10                 

gct gct ctt gct gcc ccc ttt gat gat gat gac aag atc gtt ggg ggc         98
Ala Ala Leu Ala Ala Pro Phe Asp Asp Asp Asp Lys Ile Val Gly Gly           
            15                  20                  25                    

tac aac tgt gag gag aat tct gtc ccc tac cag gtg tcc ctg aat tct        146
Tyr Asn Cys Glu Glu Asn Ser Val Pro Tyr Gln Val Ser Leu Asn Ser           
        30                  35                  40                        

ggc tac cac ttc tgt ggt ggc tcc ctc atc aac gaa cag tgg gtg gta        194
Gly Tyr His Phe Cys Gly Gly Ser Leu Ile Asn Glu Gln Trp Val Val           
    45                  50                  55                            

tca gca ggc cac tgc tac aag tcc cgc atc cag gtg aga ctg gga gag        242
Ser Ala Gly His Cys Tyr Lys Ser Arg Ile Gln Val Arg Leu Gly Glu           
60                  65                  70                  75            

cac aac atc gaa gtc ctg gag ggg aat gag cag ttc atc aat gca gcc        290
His Asn Ile Glu Val Leu Glu Gly Asn Glu Gln Phe Ile Asn Ala Ala           
                80                  85                  90                

aag atc atc cgc cac ccc caa tac gac agg aag act ctg aac aat gac        338
Lys Ile Ile Arg His Pro Gln Tyr Asp Arg Lys Thr Leu Asn Asn Asp           
            95                  100                 105                   

atc atg tta atc aag ctc tcc tca cgt gca gta atc aac gcc cgc gtg        386
Ile Met Leu Ile Lys Leu Ser Ser Arg Ala Val Ile Asn Ala Arg Val           
        110                 115                 120                       

tcc acc atc tct ctg ccc acc gcc cct cca gcc act ggc acg aag tgc        434
Ser Thr Ile Ser Leu Pro Thr Ala Pro Pro Ala Thr Gly Thr Lys Cys           
    125                 130                 135                           

ctc atc tct ggc tgg ggc aac act gcg agc tct ggc gcc gac tac cca        482
Leu Ile Ser Gly Trp Gly Asn Thr Ala Ser Ser Gly Ala Asp Tyr Pro           
140                 145                 150                 155           

gac gag ctg cag tgc ctg gat gct cct gtg ctg agc cag gct aag tgt        530
Asp Glu Leu Gln Cys Leu Asp Ala Pro Val Leu Ser Gln Ala Lys Cys           
                160                 165                 170               

gaa gcc tcc tac cct gga aag att acc agc aac atg ttc tgt gtg ggc        578
Glu Ala Ser Tyr Pro Gly Lys Ile Thr Ser Asn Met Phe Cys Val Gly           
            175                 180                 185                   

ttc ctt gag gga ggc aag gat tca tgt cag ggt gat tct ggt ggc cct        626
Phe Leu Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro           
        190                 195                 200                       

gtg gtc tgc aat gga cag ctc caa gga gtt gtc tcc tgg ggt gat ggc        674
Val Val Cys Asn Gly Gln Leu Gln Gly Val Val Ser Trp Gly Asp Gly           
    205                 210                 215                           

tgt gcc cag aag aac aag cct gga gtc tac acc aag gtc tac aac tat        722
Cys Ala Gln Lys Asn Lys Pro Gly Val Tyr Thr Lys Val Tyr Asn Tyr           
220                 225                 230                 235           

gtg aaa tgg att aag aac acc ata gct gcc aat agc taa agcccccagt         771
Val Lys Trp Ile Lys Asn Thr Ile Ala Ala Asn Ser                           
                240                 245                                   

atctcttcag tctctatacc aataaagtga ccctgttctc actgtcaaaa aaaaaaaaaa      831


<210>  30
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asn Pro Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Leu Ala Ala 
1               5                   10                  15      


Pro Phe Asp Asp Asp Asp Lys Ile Val Gly Gly Tyr Asn Cys Glu Glu 
            20                  25                  30          


Asn Ser Val Pro Tyr Gln Val Ser Leu Asn Ser Gly Tyr His Phe Cys 
        35                  40                  45              


Gly Gly Ser Leu Ile Asn Glu Gln Trp Val Val Ser Ala Gly His Cys 
    50                  55                  60                  


Tyr Lys Ser Arg Ile Gln Val Arg Leu Gly Glu His Asn Ile Glu Val 
65                  70                  75                  80  


Leu Glu Gly Asn Glu Gln Phe Ile Asn Ala Ala Lys Ile Ile Arg His 
                85                  90                  95      


Pro Gln Tyr Asp Arg Lys Thr Leu Asn Asn Asp Ile Met Leu Ile Lys 
            100                 105                 110         


Leu Ser Ser Arg Ala Val Ile Asn Ala Arg Val Ser Thr Ile Ser Leu 
        115                 120                 125             


Pro Thr Ala Pro Pro Ala Thr Gly Thr Lys Cys Leu Ile Ser Gly Trp 
    130                 135                 140                 


Gly Asn Thr Ala Ser Ser Gly Ala Asp Tyr Pro Asp Glu Leu Gln Cys 
145                 150                 155                 160 


Leu Asp Ala Pro Val Leu Ser Gln Ala Lys Cys Glu Ala Ser Tyr Pro 
                165                 170                 175     


Gly Lys Ile Thr Ser Asn Met Phe Cys Val Gly Phe Leu Glu Gly Gly 
            180                 185                 190         


Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly 
        195                 200                 205             


Gln Leu Gln Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln Lys Asn 
    210                 215                 220                 


Lys Pro Gly Val Tyr Thr Lys Val Tyr Asn Tyr Val Lys Trp Ile Lys 
225                 230                 235                 240 


Asn Thr Ile Ala Ala Asn Ser 
                245         


<210>  31
<211>  802
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (7)..(750)

<400>  31
accacc atg aat cta ctt ctg atc ctt acc ttt gtt gca gct gct gtt          48
       Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val            
       1               5                   10                             

gct gcc ccc ttt gat gat gat gac aag atc gtt ggg ggc tac atc tgt         96
Ala Ala Pro Phe Asp Asp Asp Asp Lys Ile Val Gly Gly Tyr Ile Cys           
15                  20                  25                  30            

gag gag aat tct gtc ccc tac cag gtg tcc ttg aat tct ggc tac cac        144
Glu Glu Asn Ser Val Pro Tyr Gln Val Ser Leu Asn Ser Gly Tyr His           
                35                  40                  45                

ttc tgc ggt ggc tcc ctc atc agc gaa cag tgg gtg gtg tca gca ggt        192
Phe Cys Gly Gly Ser Leu Ile Ser Glu Gln Trp Val Val Ser Ala Gly           
            50                  55                  60                    

cac tgc tac aag tcc cgc atc cag gtg aga ctg gga gag cac aac atc        240
His Cys Tyr Lys Ser Arg Ile Gln Val Arg Leu Gly Glu His Asn Ile           
        65                  70                  75                        

gaa gtc ctg gag ggg aat gaa cag ttc atc aat gca gcc aag atc atc        288
Glu Val Leu Glu Gly Asn Glu Gln Phe Ile Asn Ala Ala Lys Ile Ile           
    80                  85                  90                            

cgc cac ccc aaa tac aac agc cgg act ctg gac aat gac atc ctg ctg        336
Arg His Pro Lys Tyr Asn Ser Arg Thr Leu Asp Asn Asp Ile Leu Leu           
95                  100                 105                 110           

atc aag ctc tcc tca cct gcc gtc atc aat tcc cgc gtg tcc gcc atc        384
Ile Lys Leu Ser Ser Pro Ala Val Ile Asn Ser Arg Val Ser Ala Ile           
                115                 120                 125               

tct ctg ccc act gcc cct cca gct gct ggc acc gag tcc ctc atc tcc        432
Ser Leu Pro Thr Ala Pro Pro Ala Ala Gly Thr Glu Ser Leu Ile Ser           
            130                 135                 140                   

ggc tgg ggc aac act ctg agt tct ggt gcc gac tac cca gac gag ctg        480
Gly Trp Gly Asn Thr Leu Ser Ser Gly Ala Asp Tyr Pro Asp Glu Leu           
        145                 150                 155                       

cag tgc ctg gat gct cct gtg ctg agc cag gct gag tgt gaa gcc tcc        528
Gln Cys Leu Asp Ala Pro Val Leu Ser Gln Ala Glu Cys Glu Ala Ser           
    160                 165                 170                           

tac cct gga aag att acc aac aac atg ttc tgt gtg ggc ttc ctc gag        576
Tyr Pro Gly Lys Ile Thr Asn Asn Met Phe Cys Val Gly Phe Leu Glu           
175                 180                 185                 190           

gga ggc aag gat tcc tgc cag ggt gat tct ggt ggc cct gtg gtc tcc        624
Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Val Val Ser           
                195                 200                 205               

aat gga gag ctc caa gga att gtc tcc tgg ggc tat ggc tgt gcc cag        672
Asn Gly Glu Leu Gln Gly Ile Val Ser Trp Gly Tyr Gly Cys Ala Gln           
            210                 215                 220                   

aag aac agg cct gga gtc tac acc aag gtc tac aac tat gtg gac tgg        720
Lys Asn Arg Pro Gly Val Tyr Thr Lys Val Tyr Asn Tyr Val Asp Trp           
        225                 230                 235                       

att aag gac acc ata gct gcc aac agc taa agcccctggt ccctctgcag          770
Ile Lys Asp Thr Ile Ala Ala Asn Ser                                       
    240                 245                                               

tctctatacc aataaagtga ccctgctctc ac                                    802


<210>  32
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala Ala 
1               5                   10                  15      


Pro Phe Asp Asp Asp Asp Lys Ile Val Gly Gly Tyr Ile Cys Glu Glu 
            20                  25                  30          


Asn Ser Val Pro Tyr Gln Val Ser Leu Asn Ser Gly Tyr His Phe Cys 
        35                  40                  45              


Gly Gly Ser Leu Ile Ser Glu Gln Trp Val Val Ser Ala Gly His Cys 
    50                  55                  60                  


Tyr Lys Ser Arg Ile Gln Val Arg Leu Gly Glu His Asn Ile Glu Val 
65                  70                  75                  80  


Leu Glu Gly Asn Glu Gln Phe Ile Asn Ala Ala Lys Ile Ile Arg His 
                85                  90                  95      


Pro Lys Tyr Asn Ser Arg Thr Leu Asp Asn Asp Ile Leu Leu Ile Lys 
            100                 105                 110         


Leu Ser Ser Pro Ala Val Ile Asn Ser Arg Val Ser Ala Ile Ser Leu 
        115                 120                 125             


Pro Thr Ala Pro Pro Ala Ala Gly Thr Glu Ser Leu Ile Ser Gly Trp 
    130                 135                 140                 


Gly Asn Thr Leu Ser Ser Gly Ala Asp Tyr Pro Asp Glu Leu Gln Cys 
145                 150                 155                 160 


Leu Asp Ala Pro Val Leu Ser Gln Ala Glu Cys Glu Ala Ser Tyr Pro 
                165                 170                 175     


Gly Lys Ile Thr Asn Asn Met Phe Cys Val Gly Phe Leu Glu Gly Gly 
            180                 185                 190         


Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Val Val Ser Asn Gly 
        195                 200                 205             


Glu Leu Gln Gly Ile Val Ser Trp Gly Tyr Gly Cys Ala Gln Lys Asn 
    210                 215                 220                 


Arg Pro Gly Val Tyr Thr Lys Val Tyr Asn Tyr Val Asp Trp Ile Lys 
225                 230                 235                 240 


Asp Thr Ile Ala Ala Asn Ser 
                245         


<210>  33
<211>  908
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (45)..(908)

<400>  33
agctggaggc caggggagaa actccagaag gagagacatt tgcc atg gct gag cac        56
                                                 Met Ala Glu His          
                                                 1                        

ttc aaa cag atc att aga tgt cct gtc tgt cta aaa gat ctt gaa gaa        104
Phe Lys Gln Ile Ile Arg Cys Pro Val Cys Leu Lys Asp Leu Glu Glu           
5                   10                  15                  20            

gcc gtg caa ctg aaa tgt gga tat gcc tgc tgc ctc cag tgc ctc aat        152
Ala Val Gln Leu Lys Cys Gly Tyr Ala Cys Cys Leu Gln Cys Leu Asn           
                25                  30                  35                

tca ctc cag aag gag ccc gat ggg gaa ggt tta ctg tgc cgt ttc tgc        200
Ser Leu Gln Lys Glu Pro Asp Gly Glu Gly Leu Leu Cys Arg Phe Cys           
            40                  45                  50                    

tct gtg gtc tct cag aag gat gac atc aag ccc aag tac aag ctg agg        248
Ser Val Val Ser Gln Lys Asp Asp Ile Lys Pro Lys Tyr Lys Leu Arg           
        55                  60                  65                        

gcg ctg gtt tcc atc atc aag gaa cta gag ccc aag ctg aaa tct gtt        296
Ala Leu Val Ser Ile Ile Lys Glu Leu Glu Pro Lys Leu Lys Ser Val           
    70                  75                  80                            

cta aca atg aac cca agg atg agg aag ttt caa gtg gat atg acg ttc        344
Leu Thr Met Asn Pro Arg Met Arg Lys Phe Gln Val Asp Met Thr Phe           
85                  90                  95                  100           

gat gtg gac aca gcc aac aac tat ctc atc att tct gaa gac ctg agg        392
Asp Val Asp Thr Ala Asn Asn Tyr Leu Ile Ile Ser Glu Asp Leu Arg           
                105                 110                 115               

agt ttc cga agt ggg gat ttg agc cag aat agg aag gag caa gct gag        440
Ser Phe Arg Ser Gly Asp Leu Ser Gln Asn Arg Lys Glu Gln Ala Glu           
            120                 125                 130                   

agg ttc gac act gcc ctg tgc gtc ctg ggc acc cct cgc ttc act tcc        488
Arg Phe Asp Thr Ala Leu Cys Val Leu Gly Thr Pro Arg Phe Thr Ser           
        135                 140                 145                       

ggc cgc cat tac tgg gag gtg gac gtg ggc acc agc caa gtg tgg gat        536
Gly Arg His Tyr Trp Glu Val Asp Val Gly Thr Ser Gln Val Trp Asp           
    150                 155                 160                           

gtg ggc gtg tgc aag gaa tct gtg aac cga cag ggg aag att gtg ctt        584
Val Gly Val Cys Lys Glu Ser Val Asn Arg Gln Gly Lys Ile Val Leu           
165                 170                 175                 180           

tct tca gaa cac ggc ttc ttg act gtg ggt tgc aga gaa gga aag gtc        632
Ser Ser Glu His Gly Phe Leu Thr Val Gly Cys Arg Glu Gly Lys Val           
                185                 190                 195               

ttt gct gcc agc act gtg cct atg act cct ctc tgg gtg agt ccc cag        680
Phe Ala Ala Ser Thr Val Pro Met Thr Pro Leu Trp Val Ser Pro Gln           
            200                 205                 210                   

ttg cac aga gtg ggg att ttc ctg gat gta ggt atg agg tcc att gcc        728
Leu His Arg Val Gly Ile Phe Leu Asp Val Gly Met Arg Ser Ile Ala           
        215                 220                 225                       

ttt tac aat gtt agt gat ggg tgc cat atc tac aca ttc atc gag att        776
Phe Tyr Asn Val Ser Asp Gly Cys His Ile Tyr Thr Phe Ile Glu Ile           
    230                 235                 240                           

cct gtt tgc gag ccc tgg cgt cca ttt ttt gct cat aaa cgt gga agt        824
Pro Val Cys Glu Pro Trp Arg Pro Phe Phe Ala His Lys Arg Gly Ser           
245                 250                 255                 260           

caa gat gat cag agc atc ctg agt atc tgt tct gtg atc aat cca tcc        872
Gln Asp Asp Gln Ser Ile Leu Ser Ile Cys Ser Val Ile Asn Pro Ser           
                265                 270                 275               

gct gcc agt gcc cca gtt tct tct gag gga aag taa                        908
Ala Ala Ser Ala Pro Val Ser Ser Glu Gly Lys                               
            280                 285                                       


<210>  34
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Glu His Phe Lys Gln Ile Ile Arg Cys Pro Val Cys Leu Lys 
1               5                   10                  15      


Asp Leu Glu Glu Ala Val Gln Leu Lys Cys Gly Tyr Ala Cys Cys Leu 
            20                  25                  30          


Gln Cys Leu Asn Ser Leu Gln Lys Glu Pro Asp Gly Glu Gly Leu Leu 
        35                  40                  45              


Cys Arg Phe Cys Ser Val Val Ser Gln Lys Asp Asp Ile Lys Pro Lys 
    50                  55                  60                  


Tyr Lys Leu Arg Ala Leu Val Ser Ile Ile Lys Glu Leu Glu Pro Lys 
65                  70                  75                  80  


Leu Lys Ser Val Leu Thr Met Asn Pro Arg Met Arg Lys Phe Gln Val 
                85                  90                  95      


Asp Met Thr Phe Asp Val Asp Thr Ala Asn Asn Tyr Leu Ile Ile Ser 
            100                 105                 110         


Glu Asp Leu Arg Ser Phe Arg Ser Gly Asp Leu Ser Gln Asn Arg Lys 
        115                 120                 125             


Glu Gln Ala Glu Arg Phe Asp Thr Ala Leu Cys Val Leu Gly Thr Pro 
    130                 135                 140                 


Arg Phe Thr Ser Gly Arg His Tyr Trp Glu Val Asp Val Gly Thr Ser 
145                 150                 155                 160 


Gln Val Trp Asp Val Gly Val Cys Lys Glu Ser Val Asn Arg Gln Gly 
                165                 170                 175     


Lys Ile Val Leu Ser Ser Glu His Gly Phe Leu Thr Val Gly Cys Arg 
            180                 185                 190         


Glu Gly Lys Val Phe Ala Ala Ser Thr Val Pro Met Thr Pro Leu Trp 
        195                 200                 205             


Val Ser Pro Gln Leu His Arg Val Gly Ile Phe Leu Asp Val Gly Met 
    210                 215                 220                 


Arg Ser Ile Ala Phe Tyr Asn Val Ser Asp Gly Cys His Ile Tyr Thr 
225                 230                 235                 240 


Phe Ile Glu Ile Pro Val Cys Glu Pro Trp Arg Pro Phe Phe Ala His 
                245                 250                 255     


Lys Arg Gly Ser Gln Asp Asp Gln Ser Ile Leu Ser Ile Cys Ser Val 
            260                 265                 270         


Ile Asn Pro Ser Ala Ala Ser Ala Pro Val Ser Ser Glu Gly Lys 
        275                 280                 285         


<210>  35
<211>  2720
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (148)..(1266)

<400>  35
agaggggcgg gagctctggc tcaggtaaaa actctttctt cggctcgcga gctgagagga       60

gcaggtagag gggcagaggc gggactgtcg tctgggggag ccgcccagga ggctcctcag      120

gccgacccca gaccctggct ggccagg atg aag tat ctc cgg cac cgg cgg ccc      174
                              Met Lys Tyr Leu Arg His Arg Arg Pro         
                              1               5                           

aat gcc acc ctc att ctg gcc atc ggc gct ttc acc ctc ctc ctc ttc        222
Asn Ala Thr Leu Ile Leu Ala Ile Gly Ala Phe Thr Leu Leu Leu Phe           
10                  15                  20                  25            

agt ctg cta gtg tca cca ccc acc tgc aag gtc cag gag cag cca ccg        270
Ser Leu Leu Val Ser Pro Pro Thr Cys Lys Val Gln Glu Gln Pro Pro           
                30                  35                  40                

gcg atc ccc gag gcc ctg gcc tgg ccc act cca ccc acc cgc cca gcc        318
Ala Ile Pro Glu Ala Leu Ala Trp Pro Thr Pro Pro Thr Arg Pro Ala           
            45                  50                  55                    

ccg gcc ccg tgc cat gcc aac acc tct atg gtc acc cac ccg gac ttc        366
Pro Ala Pro Cys His Ala Asn Thr Ser Met Val Thr His Pro Asp Phe           
        60                  65                  70                        

gcc acg cag ccg cag cac gtt cag aac ttc ctc ctg tac aga cac tgc        414
Ala Thr Gln Pro Gln His Val Gln Asn Phe Leu Leu Tyr Arg His Cys           
    75                  80                  85                            

cgc cac ttt ccc ctg ctg cag gac gtg ccc ccc tct aag tgc gcg cag        462
Arg His Phe Pro Leu Leu Gln Asp Val Pro Pro Ser Lys Cys Ala Gln           
90                  95                  100                 105           

ccg gtc ttc ctg ctg ctg gtg atc aag tcc tcc cct agc aac tat gtg        510
Pro Val Phe Leu Leu Leu Val Ile Lys Ser Ser Pro Ser Asn Tyr Val           
                110                 115                 120               

cgc cgc gag ctg ctg cgg cgc acg tgg ggc cgc gag cgc aag gta cgg        558
Arg Arg Glu Leu Leu Arg Arg Thr Trp Gly Arg Glu Arg Lys Val Arg           
            125                 130                 135                   

ggt ttg cag ctg cgc ctc ctc ttc ctg gtg ggc aca gcc tcc aac ccg        606
Gly Leu Gln Leu Arg Leu Leu Phe Leu Val Gly Thr Ala Ser Asn Pro           
        140                 145                 150                       

cac gag gcc cgc aag gtc aac cgg ctg ctg gag ctg gag gca cag act        654
His Glu Ala Arg Lys Val Asn Arg Leu Leu Glu Leu Glu Ala Gln Thr           
    155                 160                 165                           

cac gga gac atc ctg cag tgg gac ttc cac gac tcc ttc ttc aac ctc        702
His Gly Asp Ile Leu Gln Trp Asp Phe His Asp Ser Phe Phe Asn Leu           
170                 175                 180                 185           

acg ctc aag cag gtc ctg ttc tta cag tgg cag gag aca agg tgc gcc        750
Thr Leu Lys Gln Val Leu Phe Leu Gln Trp Gln Glu Thr Arg Cys Ala           
                190                 195                 200               

aac gcc agc ttc gtg ctc aac ggg gat gat gac gtc ttt gca cac aca        798
Asn Ala Ser Phe Val Leu Asn Gly Asp Asp Asp Val Phe Ala His Thr           
            205                 210                 215                   

gac aac atg gtc ttc tac ctg cag gac cat gac cct ggc cgc cac ctc        846
Asp Asn Met Val Phe Tyr Leu Gln Asp His Asp Pro Gly Arg His Leu           
        220                 225                 230                       

ttc gtg ggg caa ctg atc caa aac gtg ggc ccc atc cgg gct ttt tgg        894
Phe Val Gly Gln Leu Ile Gln Asn Val Gly Pro Ile Arg Ala Phe Trp           
    235                 240                 245                           

agc aag tac tat gtg cca gag gtg gtg act cag aat gag cgg tac cca        942
Ser Lys Tyr Tyr Val Pro Glu Val Val Thr Gln Asn Glu Arg Tyr Pro           
250                 255                 260                 265           

ccc tat tgt ggg ggt ggt ggc ttc ttg ctg tcc cgc ttc acg gcc gct        990
Pro Tyr Cys Gly Gly Gly Gly Phe Leu Leu Ser Arg Phe Thr Ala Ala           
                270                 275                 280               

gcc ctg cgc cgt gct gcc cat gtc ttg gac atc ttc ccc att gat gat       1038
Ala Leu Arg Arg Ala Ala His Val Leu Asp Ile Phe Pro Ile Asp Asp           
            285                 290                 295                   

gtc ttc ctg ggt atg tgt ctg gag ctt gag gga ctg aag cct gcc tcc       1086
Val Phe Leu Gly Met Cys Leu Glu Leu Glu Gly Leu Lys Pro Ala Ser           
        300                 305                 310                       

cac agc ggc atc cgc acg tct ggc gtg cgg gct cca tcg caa cgc ctg       1134
His Ser Gly Ile Arg Thr Ser Gly Val Arg Ala Pro Ser Gln Arg Leu           
    315                 320                 325                           

tcc tcc ttt gac ccc tgc ttc tac cga gac ctg ctg ctg gtg cac cgc       1182
Ser Ser Phe Asp Pro Cys Phe Tyr Arg Asp Leu Leu Leu Val His Arg           
330                 335                 340                 345           

ttc cta cct tat gag atg ctg ctc atg tgg gat gcg ctg aac cag ccc       1230
Phe Leu Pro Tyr Glu Met Leu Leu Met Trp Asp Ala Leu Asn Gln Pro           
                350                 355                 360               

aac ctc acc tgc ggc aat cag aca cag atc tac tga gtcagcatca            1276
Asn Leu Thr Cys Gly Asn Gln Thr Gln Ile Tyr                               
            365                 370                                       

gggtccccag cctctgggct cctgtttcca taggaagggg cgacaccttc ctcccaggaa     1336

gctgagacct ttgtggtctg agcataaggg agtgccaggg aaggtttgag gtttgatgag     1396

tgaatattct ggctggcgaa ctcctacaca tccttcaaaa cccacctggt actgttccag     1456

catcttccct ggatggctgg aggaactcca gaaaatatcc atcttctttt tgtggctgct     1516

aatggcagaa gtgcctgtgc tagagttcca actgtggatg catccgtccc gtttgagtca     1576

aagtcttact tccctgctct cacctactca cagacgggat gctaagcagt gcacctgcag     1636

tggtttaatg gcagataagc tccgtctgca gttccaggcc agccagaaac tcctgtgtcc     1696

acatagagct gacgtgagaa atatctttca gcccaggaga gaggggtcct gatcttaacc     1756

ctttcctggg tctcagacaa ctcagaaggt tggggggata ccagagaggt ggtggaatag     1816

gaccgccccc tccttacttg tgggatcaaa tgctgtaatg gtggaggtgt gggcagagga     1876

gggaggcaag tgtcctttga aagttgtgag agctcagagt ttctggggtc ctcattagga     1936

gcccccatcc ctgtgttccc caagaattca gagaacagca ctggggctgg aatgatcttt     1996

aatgggccca aggccaacag gcatatgcct cactactgcc tggagaaggg agagattcag     2056

gtcctccagc agcctccctc acccagtatg ttttacagat tacgggggga ccgggtgagc     2116

cagtgacccc ctgtagcccc cagcttcagg cctcagtgtc tgccagtcaa gcttcacagg     2176

cattgtgatg gggcagcctt ggggaatata aaattttgtg aagacttgga gatctttttt     2236

tttttttaag caaatttaca agtttcaaca gacaagtcca cattcatccc taaaagtctc     2296

attttccagt agaaaatata cactggtaaa aacggggcat ggggccgtgg ctcagggctg     2356

taattctagc acattgggag accaaagtgg gaggatcact tgagcccagg agttctggat     2416

cctgtctctg cacaaaataa aaaattactc aggcgtggtg gtgctcacat gcctgtagtc     2476

ccagctatac ttgggaggct gaggcgagag gatcgcttga gcccaggagt tggaggctgc     2536

agtgaaccat gattgcgcca ctgtactcca ctgggcggca ataagaagac aaaaacataa     2596

aacaggacat gtgtgaggca aaagctgcag gaatttctat caggcagatc tgacctcatc     2656

ccacccaccc cctgctcaga tacccttcat agctccttat tgctttcagc tcataacccc     2716

acat                                                                  2720


<210>  36
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 
1               5                   10                  15      


Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 
            20                  25                  30          


Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 
        35                  40                  45              


Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 
    50                  55                  60                  


Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 
65                  70                  75                  80  


Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu Gln 
                85                  90                  95      


Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu Val 
            100                 105                 110         


Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg Arg 
        115                 120                 125             


Thr Trp Gly Arg Glu Arg Lys Val Arg Gly Leu Gln Leu Arg Leu Leu 
    130                 135                 140                 


Phe Leu Val Gly Thr Ala Ser Asn Pro His Glu Ala Arg Lys Val Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Leu Glu Ala Gln Thr His Gly Asp Ile Leu Gln Trp 
                165                 170                 175     


Asp Phe His Asp Ser Phe Phe Asn Leu Thr Leu Lys Gln Val Leu Phe 
            180                 185                 190         


Leu Gln Trp Gln Glu Thr Arg Cys Ala Asn Ala Ser Phe Val Leu Asn 
        195                 200                 205             


Gly Asp Asp Asp Val Phe Ala His Thr Asp Asn Met Val Phe Tyr Leu 
    210                 215                 220                 


Gln Asp His Asp Pro Gly Arg His Leu Phe Val Gly Gln Leu Ile Gln 
225                 230                 235                 240 


Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr Val Pro Glu 
                245                 250                 255     


Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly Gly Gly Gly 
            260                 265                 270         


Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg Ala Ala His 
        275                 280                 285             


Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu 
    290                 295                 300                 


Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile Arg Thr Ser 
305                 310                 315                 320 


Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp Pro Cys Phe 
                325                 330                 335     


Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr Glu Met Leu 
            340                 345                 350         


Leu Met Trp Asp Ala Leu Asn Gln Pro Asn Leu Thr Cys Gly Asn Gln 
        355                 360                 365             


Thr Gln Ile Tyr 
    370         


<210>  37
<211>  2161
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (168)..(917)

<400>  37
tttttaactt gtttaactaa gggtggctcc tgttgagagg tgacagcgtg ttggcagccc       60

tcgcagccct cgcttgctct tggtgcctcc tcagcctcgg cgcccactct ggccgcactt      120

gaggagccct tcagcccgct gctgcactgt gggagtccct tcctggg atg gcc gag        176
                                                    Met Ala Glu           
                                                    1                     

gcc gga gcc ggc tcc ctc agc ctt ccg gga gga aaa gcc atg gag act        224
Ala Gly Ala Gly Ser Leu Ser Leu Pro Gly Gly Lys Ala Met Glu Thr           
    5                   10                  15                            

tca gca tcc tcc tcc cag cct cag gac aac agt caa gtc cac aga gaa        272
Ser Ala Ser Ser Ser Gln Pro Gln Asp Asn Ser Gln Val His Arg Glu           
20                  25                  30                  35            

aca gaa gat gta gac tat gga gag aca gat ttc cac aag caa gat ggg        320
Thr Glu Asp Val Asp Tyr Gly Glu Thr Asp Phe His Lys Gln Asp Gly           
                40                  45                  50                

aag gct gga ctc ttt tcc caa gaa caa tat gag aga aac aag tct tct        368
Lys Ala Gly Leu Phe Ser Gln Glu Gln Tyr Glu Arg Asn Lys Ser Ser           
            55                  60                  65                    

tcc tcc tcc tcc tct tcc tcc tca tcc tcc tca tct tct tca tcc tcc        416
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser           
        70                  75                  80                        

tcc tcc tca gag agc aat gat gag gac cag caa ccc aga gca acc gga        464
Ser Ser Ser Glu Ser Asn Asp Glu Asp Gln Gln Pro Arg Ala Thr Gly           
    85                  90                  95                            

aaa cat cga cgg agc ctg ggg gct gga tac ccc cac ggg aac ggc tca        512
Lys His Arg Arg Ser Leu Gly Ala Gly Tyr Pro His Gly Asn Gly Ser           
100                 105                 110                 115           

ccc ggt cct ggg cat ggg gag cct gac gtt ttg aag gat gag ctt caa        560
Pro Gly Pro Gly His Gly Glu Pro Asp Val Leu Lys Asp Glu Leu Gln           
                120                 125                 130               

ctc tat gga gat gct cct gga gag gtg gta ccc tct ggg gaa tca gga        608
Leu Tyr Gly Asp Ala Pro Gly Glu Val Val Pro Ser Gly Glu Ser Gly           
            135                 140                 145                   

ctc cga agg aga ggc tct gac cca gca agt gga gaa gtg gag gcc tct        656
Leu Arg Arg Arg Gly Ser Asp Pro Ala Ser Gly Glu Val Glu Ala Ser           
        150                 155                 160                       

cag tta aga aga ctg aat ata aag aaa gat gat gag ttt ttc cat ttc        704
Gln Leu Arg Arg Leu Asn Ile Lys Lys Asp Asp Glu Phe Phe His Phe           
    165                 170                 175                           

gtc ctc ctg tgc ttt gcc atc ggg gcc ttg ctg gtg tgt tat cac tat        752
Val Leu Leu Cys Phe Ala Ile Gly Ala Leu Leu Val Cys Tyr His Tyr           
180                 185                 190                 195           

tac gca gac tgg ttc atg tct ctt ggg gtc ggc ctg ctc acc ttc gcc        800
Tyr Ala Asp Trp Phe Met Ser Leu Gly Val Gly Leu Leu Thr Phe Ala           
                200                 205                 210               

tcc ctg gaa acc gtt ggc atc tac ttc gga cta gtg tac cgt atc cac        848
Ser Leu Glu Thr Val Gly Ile Tyr Phe Gly Leu Val Tyr Arg Ile His           
            215                 220                 225                   

agc gtc ctc caa ggc ttc atc ccc ctc ttc cag aag ttt agg ctg aca        896
Ser Val Leu Gln Gly Phe Ile Pro Leu Phe Gln Lys Phe Arg Leu Thr           
        230                 235                 240                       

ggg ttc agg aag act gac tga ggccacttcc aggtgggcag cagaggcagg           947
Gly Phe Arg Lys Thr Asp                                                   
    245                                                                   

ccccagtgtg accaccactg cgacccctga gcccacaagg gcagagcagc attctgagag     1007

acgcacagga gaccaagcca gaccaataaa cagaacactt ttccttccat gtggtctgaa     1067

tgttggcacc agcccgggca ggggcatctc atttgggcag tactgctgtg caacccagct     1127

gcaaggatgg aaggcagagg gtgggtgtgg ggcctgaggc ttcacagtac ctggaccagc     1187

aggaagattc tgggaggtca ctgctctcag aggacagcaa gggaccctga gctctgcaag     1247

ctgtgatctg tctgggttca tggtttttct caaatcccag gctatctgca tgcgctctca     1307

ggtgctaccg agccatcctg ggagagatgg atggtccact gctttgaggc agggagccat     1367

cgggctgggg ccccttggtg aacctgatgc aggtaagatg ctgaggacta aaaccatttt     1427

ttttgcaccc aaaaaaaaag gcaggaaaat gatcatcaga aactaaatgg cagccaggca     1487

tgggggctca caactgtaat cctcgcactt tgggaggctc aggctaaggg tcgcttgaag     1547

ctgagagttc aagaccaacc tgggcaacat agtgagaccc ccatctctac aatttttttt     1607

taatgaccaa atgtggcggt acatacctgt acatacctgc ggttccagct actcaagagg     1667

ctgaggcagg aggactgctt gagcccagga gttcagggct gcagtgaggt acgatcaagc     1727

cactgcactc cagcctgggc gacagagcaa gatcgtttct ctaaaattaa aaaaaaaaaa     1787

aaaagacaaa taaaaattgc atgtatttgt agtgtacaac atgttttgaa atatgtggaa     1847

tggctaaatc aagctaatta acatatgtat ccctcacata cccttttttt atgatgagaa     1907

cagtaaaaac ctactgtcag caatttgcaa agtatacaat acattgttat taactatggt     1967

caccatgcta tgtgattgat atcctgaact tgaactgagt tcttgatggt cacagacatg     2027

ctgttctcaa aactcagaag ggtaacttct gaggttttga tttcaagtac ttgtatgtaa     2087

cctaatttaa cgggagccca gagtgcacag atcagatatt tattaaacat ataaataaaa     2147

cacagttttc acga                                                       2161


<210>  38
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Glu Ala Gly Ala Gly Ser Leu Ser Leu Pro Gly Gly Lys Ala 
1               5                   10                  15      


Met Glu Thr Ser Ala Ser Ser Ser Gln Pro Gln Asp Asn Ser Gln Val 
            20                  25                  30          


His Arg Glu Thr Glu Asp Val Asp Tyr Gly Glu Thr Asp Phe His Lys 
        35                  40                  45              


Gln Asp Gly Lys Ala Gly Leu Phe Ser Gln Glu Gln Tyr Glu Arg Asn 
    50                  55                  60                  


Lys Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Ser Glu Ser Asn Asp Glu Asp Gln Gln Pro Arg 
                85                  90                  95      


Ala Thr Gly Lys His Arg Arg Ser Leu Gly Ala Gly Tyr Pro His Gly 
            100                 105                 110         


Asn Gly Ser Pro Gly Pro Gly His Gly Glu Pro Asp Val Leu Lys Asp 
        115                 120                 125             


Glu Leu Gln Leu Tyr Gly Asp Ala Pro Gly Glu Val Val Pro Ser Gly 
    130                 135                 140                 


Glu Ser Gly Leu Arg Arg Arg Gly Ser Asp Pro Ala Ser Gly Glu Val 
145                 150                 155                 160 


Glu Ala Ser Gln Leu Arg Arg Leu Asn Ile Lys Lys Asp Asp Glu Phe 
                165                 170                 175     


Phe His Phe Val Leu Leu Cys Phe Ala Ile Gly Ala Leu Leu Val Cys 
            180                 185                 190         


Tyr His Tyr Tyr Ala Asp Trp Phe Met Ser Leu Gly Val Gly Leu Leu 
        195                 200                 205             


Thr Phe Ala Ser Leu Glu Thr Val Gly Ile Tyr Phe Gly Leu Val Tyr 
    210                 215                 220                 


Arg Ile His Ser Val Leu Gln Gly Phe Ile Pro Leu Phe Gln Lys Phe 
225                 230                 235                 240 


Arg Leu Thr Gly Phe Arg Lys Thr Asp 
                245                 


<210>  39
<211>  1812
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (409)..(1596)

<400>  39
aaagcttccc gagagccatg gttggtccag gcaggcagtc ggagcacctc gtggagcggc       60

tgctaaccca gggtggggtg gggtggggtg gaggggtctg cttgtagtac tctcagtcct      120

gatgtcacag gcgcggcaag gacatcgcaa ggaggagtcg gattacagta aggatgggca      180

gtgcagcagg cagcccgagc gcactctcca gccgccgggg atcttagccc tggaaaggca      240

gcctgcaagg cgctcatccc gcggaggagg cacgctctcg gcgctcactg ctctccacgc      300

cggggacatt tccaccgaat gtagcatgaa agggctctgc tctacgtgcc agccttgggt      360

gagagctgat gctgaagaca ccgcggtggg attccagctg tctgatta atg aga aac       417
                                                     Met Arg Asn          
                                                     1                    

ata atg tat ttt ggt ggt aca tgc cag agt cct gct ctc ccg gcc ctt        465
Ile Met Tyr Phe Gly Gly Thr Cys Gln Ser Pro Ala Leu Pro Ala Leu           
    5                   10                  15                            

gtc cgt cca cca gcc cct cct ttg caa cca tcg ctg gat att aaa cca        513
Val Arg Pro Pro Ala Pro Pro Leu Gln Pro Ser Leu Asp Ile Lys Pro           
20                  25                  30                  35            

ttt ctt ccc ttt cct ctt gac act gca gct gca gtc aac ctc ttc ccc        561
Phe Leu Pro Phe Pro Leu Asp Thr Ala Ala Ala Val Asn Leu Phe Pro           
                40                  45                  50                

aat ttc aat gcg atg gac ccg att cag aaa gct gta ata aac cat aca        609
Asn Phe Asn Ala Met Asp Pro Ile Gln Lys Ala Val Ile Asn His Thr           
            55                  60                  65                    

ttc ggg gtt cct ctt ccc cac cga aga aag caa atc ata tca tgc aac        657
Phe Gly Val Pro Leu Pro His Arg Arg Lys Gln Ile Ile Ser Cys Asn           
        70                  75                  80                        

att tgc cag ttg aga ttt aat tct gat agc cag gct gcg gcc cac tac        705
Ile Cys Gln Leu Arg Phe Asn Ser Asp Ser Gln Ala Ala Ala His Tyr           
    85                  90                  95                            

aaa ggc acg aaa cat gcc aag aag ctc aaa gca ctg gaa gcc atg aaa        753
Lys Gly Thr Lys His Ala Lys Lys Leu Lys Ala Leu Glu Ala Met Lys           
100                 105                 110                 115           

aat aag cag aaa tct gta act gcc aag gac agc gca aag act acc ttc        801
Asn Lys Gln Lys Ser Val Thr Ala Lys Asp Ser Ala Lys Thr Thr Phe           
                120                 125                 130               

acc tcc atc act acc aat acc atc aat acc agc tct gac aaa aca gac        849
Thr Ser Ile Thr Thr Asn Thr Ile Asn Thr Ser Ser Asp Lys Thr Asp           
            135                 140                 145                   

ggt act gca ggg aca cca gca ata tca acg acg aca act gtg gaa atc        897
Gly Thr Ala Gly Thr Pro Ala Ile Ser Thr Thr Thr Thr Val Glu Ile           
        150                 155                 160                       

cgc aaa agc agt gtt atg aca act gag atc acc tct aaa gtg gaa aaa        945
Arg Lys Ser Ser Val Met Thr Thr Glu Ile Thr Ser Lys Val Glu Lys           
    165                 170                 175                           

agc cca acg aca gcc act ggc aat agc tca tgt cct tct act gag acc        993
Ser Pro Thr Thr Ala Thr Gly Asn Ser Ser Cys Pro Ser Thr Glu Thr           
180                 185                 190                 195           

gag gaa gaa aag gca aaa cgg ctt ctt tac tgt tcg cta tgc aag gtt       1041
Glu Glu Glu Lys Ala Lys Arg Leu Leu Tyr Cys Ser Leu Cys Lys Val           
                200                 205                 210               

gct gtc aac tct gcc tcg cag ctg gag gcg cac aac agt ggt act aag       1089
Ala Val Asn Ser Ala Ser Gln Leu Glu Ala His Asn Ser Gly Thr Lys           
            215                 220                 225                   

cac aaa acc atg tta gaa gcc cgg aat gga agt ggc act atc aaa gcc       1137
His Lys Thr Met Leu Glu Ala Arg Asn Gly Ser Gly Thr Ile Lys Ala           
        230                 235                 240                       

ttt cct agg gca gga gtg aaa ggc aaa gga cct gtt aat aaa gga aac       1185
Phe Pro Arg Ala Gly Val Lys Gly Lys Gly Pro Val Asn Lys Gly Asn           
    245                 250                 255                           

aca ggc ctc caa aat aaa aca ttt cac tgt gaa atc tgt gat gtg cac       1233
Thr Gly Leu Gln Asn Lys Thr Phe His Cys Glu Ile Cys Asp Val His           
260                 265                 270                 275           

gtc aac tcg gaa acg caa ctt aaa cag cac att agc agt aga agg cac       1281
Val Asn Ser Glu Thr Gln Leu Lys Gln His Ile Ser Ser Arg Arg His           
                280                 285                 290               

aaa gac aga gct gct ggg aag ccc ccg aaa cct aaa tac agt cct tac       1329
Lys Asp Arg Ala Ala Gly Lys Pro Pro Lys Pro Lys Tyr Ser Pro Tyr           
            295                 300                 305                   

aac aaa cta cag aag aca gca cat cca ctg ggg gta aaa tta gta ttt       1377
Asn Lys Leu Gln Lys Thr Ala His Pro Leu Gly Val Lys Leu Val Phe           
        310                 315                 320                       

tca aaa gaa cct tca aag cca ttg gct cca cga att cta cca aat cct       1425
Ser Lys Glu Pro Ser Lys Pro Leu Ala Pro Arg Ile Leu Pro Asn Pro           
    325                 330                 335                           

cta gca gct gca gca gcc gca gca gca gtg gca gtg agt tcc ccc ttc       1473
Leu Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Val Ser Ser Pro Phe           
340                 345                 350                 355           

agt ctt cga act gct cca gca gca aca ctg ttc cag act tcc gcg ctt       1521
Ser Leu Arg Thr Ala Pro Ala Ala Thr Leu Phe Gln Thr Ser Ala Leu           
                360                 365                 370               

cct ccg gca ctc ctg cgg cca gct cct gga ccc att cgg acc gcc cac       1569
Pro Pro Ala Leu Leu Arg Pro Ala Pro Gly Pro Ile Arg Thr Ala His           
            375                 380                 385                   

act cct gtg ctg ttt gct cct tac taa attccaaata ggagtaattg             1616
Thr Pro Val Leu Phe Ala Pro Tyr                                           
        390                 395                                           

tactgcaata atttttcaaa aaacaaaaaa caaaacaaac aaaagagaac tatgcagtgt     1676

ttatttatag tttaaagtat atctgaagag ccaggacttt tgatagtgaa ttgaaaaggt     1736

tataaaaaag tgggggaggt ttgggggtgg gagggaggga gtggtatttt ctccaaatta     1796

aagcattcct cttgaa                                                     1812


<210>  40
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Arg Asn Ile Met Tyr Phe Gly Gly Thr Cys Gln Ser Pro Ala Leu 
1               5                   10                  15      


Pro Ala Leu Val Arg Pro Pro Ala Pro Pro Leu Gln Pro Ser Leu Asp 
            20                  25                  30          


Ile Lys Pro Phe Leu Pro Phe Pro Leu Asp Thr Ala Ala Ala Val Asn 
        35                  40                  45              


Leu Phe Pro Asn Phe Asn Ala Met Asp Pro Ile Gln Lys Ala Val Ile 
    50                  55                  60                  


Asn His Thr Phe Gly Val Pro Leu Pro His Arg Arg Lys Gln Ile Ile 
65                  70                  75                  80  


Ser Cys Asn Ile Cys Gln Leu Arg Phe Asn Ser Asp Ser Gln Ala Ala 
                85                  90                  95      


Ala His Tyr Lys Gly Thr Lys His Ala Lys Lys Leu Lys Ala Leu Glu 
            100                 105                 110         


Ala Met Lys Asn Lys Gln Lys Ser Val Thr Ala Lys Asp Ser Ala Lys 
        115                 120                 125             


Thr Thr Phe Thr Ser Ile Thr Thr Asn Thr Ile Asn Thr Ser Ser Asp 
    130                 135                 140                 


Lys Thr Asp Gly Thr Ala Gly Thr Pro Ala Ile Ser Thr Thr Thr Thr 
145                 150                 155                 160 


Val Glu Ile Arg Lys Ser Ser Val Met Thr Thr Glu Ile Thr Ser Lys 
                165                 170                 175     


Val Glu Lys Ser Pro Thr Thr Ala Thr Gly Asn Ser Ser Cys Pro Ser 
            180                 185                 190         


Thr Glu Thr Glu Glu Glu Lys Ala Lys Arg Leu Leu Tyr Cys Ser Leu 
        195                 200                 205             


Cys Lys Val Ala Val Asn Ser Ala Ser Gln Leu Glu Ala His Asn Ser 
    210                 215                 220                 


Gly Thr Lys His Lys Thr Met Leu Glu Ala Arg Asn Gly Ser Gly Thr 
225                 230                 235                 240 


Ile Lys Ala Phe Pro Arg Ala Gly Val Lys Gly Lys Gly Pro Val Asn 
                245                 250                 255     


Lys Gly Asn Thr Gly Leu Gln Asn Lys Thr Phe His Cys Glu Ile Cys 
            260                 265                 270         


Asp Val His Val Asn Ser Glu Thr Gln Leu Lys Gln His Ile Ser Ser 
        275                 280                 285             


Arg Arg His Lys Asp Arg Ala Ala Gly Lys Pro Pro Lys Pro Lys Tyr 
    290                 295                 300                 


Ser Pro Tyr Asn Lys Leu Gln Lys Thr Ala His Pro Leu Gly Val Lys 
305                 310                 315                 320 


Leu Val Phe Ser Lys Glu Pro Ser Lys Pro Leu Ala Pro Arg Ile Leu 
                325                 330                 335     


Pro Asn Pro Leu Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Val Ser 
            340                 345                 350         


Ser Pro Phe Ser Leu Arg Thr Ala Pro Ala Ala Thr Leu Phe Gln Thr 
        355                 360                 365             


Ser Ala Leu Pro Pro Ala Leu Leu Arg Pro Ala Pro Gly Pro Ile Arg 
    370                 375                 380                 


Thr Ala His Thr Pro Val Leu Phe Ala Pro Tyr 
385                 390                 395 


<210>  41
<211>  2397
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (111)..(2072)

<400>  41
cccagcccca gccccagccc cggccccggc cccggctcgc gggcgctgcg tctccgcgta       60

caggaggcgg cggcggctcc cagtcaccgg cccccgccgg cgagcgcacg atg cac         116
                                                       Met His            
                                                       1                  

tgc ctg ggc gcc gag tac ctg gtt tct gca gaa gga gcc cct agg caa        164
Cys Leu Gly Ala Glu Tyr Leu Val Ser Ala Glu Gly Ala Pro Arg Gln           
        5                   10                  15                        

agg gag tgg cga ccc cag att tat agg aaa tgc aca gat acg gca tgg        212
Arg Glu Trp Arg Pro Gln Ile Tyr Arg Lys Cys Thr Asp Thr Ala Trp           
    20                  25                  30                            

tta ttc ctg ttc ttt ctc ttt tgg act ggt ttg gtg ttt atc atg ggc        260
Leu Phe Leu Phe Phe Leu Phe Trp Thr Gly Leu Val Phe Ile Met Gly           
35                  40                  45                  50            

tac tcg gtg gtg gct gga gcc gcg gga aga ctc ctc ttt ggc tat gac        308
Tyr Ser Val Val Ala Gly Ala Ala Gly Arg Leu Leu Phe Gly Tyr Asp           
                55                  60                  65                

agc ttt ggc aac atg tgt ggc aag aag aac tcc ccc gtg gaa ggg gcc        356
Ser Phe Gly Asn Met Cys Gly Lys Lys Asn Ser Pro Val Glu Gly Ala           
            70                  75                  80                    

cct ctt tca ggg cag gac atg acc cta aaa aaa cac gtg ttc ttt atg        404
Pro Leu Ser Gly Gln Asp Met Thr Leu Lys Lys His Val Phe Phe Met           
        85                  90                  95                        

aat tcc tgc aac ctg gaa gtc aaa ggt acg cag ctc aac cgc atg gcc        452
Asn Ser Cys Asn Leu Glu Val Lys Gly Thr Gln Leu Asn Arg Met Ala           
    100                 105                 110                           

ctc tgt gta tcc aac tgc cct gaa gag cag ctt gac tcc ctg gaa gag        500
Leu Cys Val Ser Asn Cys Pro Glu Glu Gln Leu Asp Ser Leu Glu Glu           
115                 120                 125                 130           

gtc cag ttc ttt gca aac acc agt ggg tcc ttc ctg tgt gtt tat agt        548
Val Gln Phe Phe Ala Asn Thr Ser Gly Ser Phe Leu Cys Val Tyr Ser           
                135                 140                 145               

ttg aat tcc ttc aac tat acc cac agt cca aaa gca gac tca ctg tgt        596
Leu Asn Ser Phe Asn Tyr Thr His Ser Pro Lys Ala Asp Ser Leu Cys           
            150                 155                 160                   

ccc agg cta cca gtt cct cca agc aag tca ttt ccc tta ttt aac cga        644
Pro Arg Leu Pro Val Pro Pro Ser Lys Ser Phe Pro Leu Phe Asn Arg           
        165                 170                 175                       

tgt gtc cct caa aca cct gag tgc tac tcc cta ttt gca tct gtt ttg        692
Cys Val Pro Gln Thr Pro Glu Cys Tyr Ser Leu Phe Ala Ser Val Leu           
    180                 185                 190                           

ata aat gat gtt gac acc ctc cac cga att cta agt gga atc atg tcg        740
Ile Asn Asp Val Asp Thr Leu His Arg Ile Leu Ser Gly Ile Met Ser           
195                 200                 205                 210           

gga aga gat aca atc ctt ggc ctg tgt atc ctc gca tta gcc ttg tct        788
Gly Arg Asp Thr Ile Leu Gly Leu Cys Ile Leu Ala Leu Ala Leu Ser           
                215                 220                 225               

ttg gcc atg atg ttt acc ttc aga ttc atc acc acc ctt ctg gtt cac        836
Leu Ala Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu Val His           
            230                 235                 240                   

att ttc att tca ttg gtt att ttg gga ttg ttg ttt gtc tgc ggt gtt        884
Ile Phe Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys Gly Val           
        245                 250                 255                       

tta tgg tgg ctg tat tat gac tat acc aac gac ctc agc ata gaa ttg        932
Leu Trp Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile Glu Leu           
    260                 265                 270                           

gac aca gaa agg gaa aat atg aag tgc gtg ctg ggg ttt gct atc gta        980
Asp Thr Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala Ile Val           
275                 280                 285                 290           

tcc aca ggc atc acg gca gtg ctg ctc gtc ttg att ttt gtt ctc aga       1028
Ser Thr Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val Leu Arg           
                295                 300                 305               

aag aga ata aaa ttg aca gtt gag ctt ttc caa atc aca aat aaa gcc       1076
Lys Arg Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn Lys Ala           
            310                 315                 320                   

atc agc agt gct ccc ttc ctg ctg ttc cag cca ctg tgg aca ttt gcc       1124
Ile Ser Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr Phe Ala           
        325                 330                 335                       

atc ctc att ttc ttc tgg gtc ctc tgg gtg gct gtg ctg ctg agc ctg       1172
Ile Leu Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu Ser Leu           
    340                 345                 350                           

gga act gca gga gct gcc cag gtt atg gaa ggc ggc caa gtg gaa tat       1220
Gly Thr Ala Gly Ala Ala Gln Val Met Glu Gly Gly Gln Val Glu Tyr           
355                 360                 365                 370           

aag ccc ctt tcg ggc att cgg tac atg tgg tcg tac cat tta att ggc       1268
Lys Pro Leu Ser Gly Ile Arg Tyr Met Trp Ser Tyr His Leu Ile Gly           
                375                 380                 385               

ctc atc tgg act agt gaa ttc atc ctt gcg tgc cag caa atg act ata       1316
Leu Ile Trp Thr Ser Glu Phe Ile Leu Ala Cys Gln Gln Met Thr Ile           
            390                 395                 400                   

gct ggg gca gtg gtt act tgt tat ttc aac aga agt aaa aat gat cct       1364
Ala Gly Ala Val Val Thr Cys Tyr Phe Asn Arg Ser Lys Asn Asp Pro           
        405                 410                 415                       

cct gat cat ccc atc ctt tcg tct ctc tcc att ctc ttc ttc tac cat       1412
Pro Asp His Pro Ile Leu Ser Ser Leu Ser Ile Leu Phe Phe Tyr His           
    420                 425                 430                           

caa gga acc gtt gtg aaa ggg tca ttt tta atc tct gtg gtg agg att       1460
Gln Gly Thr Val Val Lys Gly Ser Phe Leu Ile Ser Val Val Arg Ile           
435                 440                 445                 450           

ccg aga atc att gtc atg tac atg caa aac gca ctg aaa gaa cag cag       1508
Pro Arg Ile Ile Val Met Tyr Met Gln Asn Ala Leu Lys Glu Gln Gln           
                455                 460                 465               

cat ggt gca ttg tcc agg tac ctg ttc cga tgc tgc tac tgc tgt ttc       1556
His Gly Ala Leu Ser Arg Tyr Leu Phe Arg Cys Cys Tyr Cys Cys Phe           
            470                 475                 480                   

tgg tgt ctt gac aaa tac ctg ctc cat ctc aac cag aat gca tat act       1604
Trp Cys Leu Asp Lys Tyr Leu Leu His Leu Asn Gln Asn Ala Tyr Thr           
        485                 490                 495                       

aca act gct att aat ggg aca gat ttc tgt aca tca gca aaa gat gca       1652
Thr Thr Ala Ile Asn Gly Thr Asp Phe Cys Thr Ser Ala Lys Asp Ala           
    500                 505                 510                           

ttc aaa atc ttg tcc aag aac tca agt cac ttt aca tct att aac tgc       1700
Phe Lys Ile Leu Ser Lys Asn Ser Ser His Phe Thr Ser Ile Asn Cys           
515                 520                 525                 530           

ttt gga gac ttc ata att ttt cta gga aag gtg tta gtg gtg tgt ttc       1748
Phe Gly Asp Phe Ile Ile Phe Leu Gly Lys Val Leu Val Val Cys Phe           
                535                 540                 545               

act gtt ttt gga gga ctc atg gct ttt aac tac aat cgg gca ttc cag       1796
Thr Val Phe Gly Gly Leu Met Ala Phe Asn Tyr Asn Arg Ala Phe Gln           
            550                 555                 560                   

gtg tgg gca gtc cct ctg tta ttg gta gct ttt ttt gcc tac tta gta       1844
Val Trp Ala Val Pro Leu Leu Leu Val Ala Phe Phe Ala Tyr Leu Val           
        565                 570                 575                       

gcc cat agt ttt tta tct gtg ttt gaa act gtg ctg gat gca ctt ttc       1892
Ala His Ser Phe Leu Ser Val Phe Glu Thr Val Leu Asp Ala Leu Phe           
    580                 585                 590                           

ctg tgt ttt gct gtt gat ctg gaa aca aat gat gga tcg tca gaa aag       1940
Leu Cys Phe Ala Val Asp Leu Glu Thr Asn Asp Gly Ser Ser Glu Lys           
595                 600                 605                 610           

ccc tac ttt atg gat caa gaa ttt ctg agt ttc gta aaa agg agc aac       1988
Pro Tyr Phe Met Asp Gln Glu Phe Leu Ser Phe Val Lys Arg Ser Asn           
                615                 620                 625               

aaa tta aac aat gca agg gca cag cag gac aag cac tca tta agg aat       2036
Lys Leu Asn Asn Ala Arg Ala Gln Gln Asp Lys His Ser Leu Arg Asn           
            630                 635                 640                   

gag gag gga aca gaa ctc cag gcc att gtg aga tag atacccattt            2082
Glu Glu Gly Thr Glu Leu Gln Ala Ile Val Arg                               
        645                 650                                           

aggtatctgt acctggaaaa catttccttc taagagccat ttacagaata gaagatgaga     2142

ccactagaga aaagttagtg aatttttttt taaaagacct aataaaccct attcttcctc     2202

attgtctttg tcattattgt ttgaccaggt aacaatactg gaactatatt agtttacctt     2262

tttttgtaca aattaggaca gaaaaactct tctaaaacca tgtttatatg catcaactta     2322

caaagtacac tatgtaagaa ctgaggtaag tttgtaagtg cacaactaat aaataaacct     2382

ttttaagata aggat                                                      2397


<210>  42
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  42

Met His Cys Leu Gly Ala Glu Tyr Leu Val Ser Ala Glu Gly Ala Pro 
1               5                   10                  15      


Arg Gln Arg Glu Trp Arg Pro Gln Ile Tyr Arg Lys Cys Thr Asp Thr 
            20                  25                  30          


Ala Trp Leu Phe Leu Phe Phe Leu Phe Trp Thr Gly Leu Val Phe Ile 
        35                  40                  45              


Met Gly Tyr Ser Val Val Ala Gly Ala Ala Gly Arg Leu Leu Phe Gly 
    50                  55                  60                  


Tyr Asp Ser Phe Gly Asn Met Cys Gly Lys Lys Asn Ser Pro Val Glu 
65                  70                  75                  80  


Gly Ala Pro Leu Ser Gly Gln Asp Met Thr Leu Lys Lys His Val Phe 
                85                  90                  95      


Phe Met Asn Ser Cys Asn Leu Glu Val Lys Gly Thr Gln Leu Asn Arg 
            100                 105                 110         


Met Ala Leu Cys Val Ser Asn Cys Pro Glu Glu Gln Leu Asp Ser Leu 
        115                 120                 125             


Glu Glu Val Gln Phe Phe Ala Asn Thr Ser Gly Ser Phe Leu Cys Val 
    130                 135                 140                 


Tyr Ser Leu Asn Ser Phe Asn Tyr Thr His Ser Pro Lys Ala Asp Ser 
145                 150                 155                 160 


Leu Cys Pro Arg Leu Pro Val Pro Pro Ser Lys Ser Phe Pro Leu Phe 
                165                 170                 175     


Asn Arg Cys Val Pro Gln Thr Pro Glu Cys Tyr Ser Leu Phe Ala Ser 
            180                 185                 190         


Val Leu Ile Asn Asp Val Asp Thr Leu His Arg Ile Leu Ser Gly Ile 
        195                 200                 205             


Met Ser Gly Arg Asp Thr Ile Leu Gly Leu Cys Ile Leu Ala Leu Ala 
    210                 215                 220                 


Leu Ser Leu Ala Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu 
225                 230                 235                 240 


Val His Ile Phe Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys 
                245                 250                 255     


Gly Val Leu Trp Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile 
            260                 265                 270         


Glu Leu Asp Thr Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala 
        275                 280                 285             


Ile Val Ser Thr Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val 
    290                 295                 300                 


Leu Arg Lys Arg Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn 
305                 310                 315                 320 


Lys Ala Ile Ser Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr 
                325                 330                 335     


Phe Ala Ile Leu Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu 
            340                 345                 350         


Ser Leu Gly Thr Ala Gly Ala Ala Gln Val Met Glu Gly Gly Gln Val 
        355                 360                 365             


Glu Tyr Lys Pro Leu Ser Gly Ile Arg Tyr Met Trp Ser Tyr His Leu 
    370                 375                 380                 


Ile Gly Leu Ile Trp Thr Ser Glu Phe Ile Leu Ala Cys Gln Gln Met 
385                 390                 395                 400 


Thr Ile Ala Gly Ala Val Val Thr Cys Tyr Phe Asn Arg Ser Lys Asn 
                405                 410                 415     


Asp Pro Pro Asp His Pro Ile Leu Ser Ser Leu Ser Ile Leu Phe Phe 
            420                 425                 430         


Tyr His Gln Gly Thr Val Val Lys Gly Ser Phe Leu Ile Ser Val Val 
        435                 440                 445             


Arg Ile Pro Arg Ile Ile Val Met Tyr Met Gln Asn Ala Leu Lys Glu 
    450                 455                 460                 


Gln Gln His Gly Ala Leu Ser Arg Tyr Leu Phe Arg Cys Cys Tyr Cys 
465                 470                 475                 480 


Cys Phe Trp Cys Leu Asp Lys Tyr Leu Leu His Leu Asn Gln Asn Ala 
                485                 490                 495     


Tyr Thr Thr Thr Ala Ile Asn Gly Thr Asp Phe Cys Thr Ser Ala Lys 
            500                 505                 510         


Asp Ala Phe Lys Ile Leu Ser Lys Asn Ser Ser His Phe Thr Ser Ile 
        515                 520                 525             


Asn Cys Phe Gly Asp Phe Ile Ile Phe Leu Gly Lys Val Leu Val Val 
    530                 535                 540                 


Cys Phe Thr Val Phe Gly Gly Leu Met Ala Phe Asn Tyr Asn Arg Ala 
545                 550                 555                 560 


Phe Gln Val Trp Ala Val Pro Leu Leu Leu Val Ala Phe Phe Ala Tyr 
                565                 570                 575     


Leu Val Ala His Ser Phe Leu Ser Val Phe Glu Thr Val Leu Asp Ala 
            580                 585                 590         


Leu Phe Leu Cys Phe Ala Val Asp Leu Glu Thr Asn Asp Gly Ser Ser 
        595                 600                 605             


Glu Lys Pro Tyr Phe Met Asp Gln Glu Phe Leu Ser Phe Val Lys Arg 
    610                 615                 620                 


Ser Asn Lys Leu Asn Asn Ala Arg Ala Gln Gln Asp Lys His Ser Leu 
625                 630                 635                 640 


Arg Asn Glu Glu Gly Thr Glu Leu Gln Ala Ile Val Arg 
                645                 650             


<210>  43
<211>  3130
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (251)..(1399)

<400>  43
gagtcagtgg cttgaaactt ttaaaagctc tgtgctccaa gttacaaaaa agcttttacg       60

aggtatcagc acttttcttt cattaggggg aaggcgtgag gaaagtacca aacagcagcg      120

gagttttaaa ctttaaatag acaggtctga gtgcctgaac ttgccttttc attttacttc      180

atcctccaag gagttcaatc acttggcgtg acttcactac ttttaagcaa aagagtggtg      240

cccaggcaac atg ggt gac tgg agc gcc tta ggc aaa ctc ctt gac aag         289
           Met Gly Asp Trp Ser Ala Leu Gly Lys Leu Leu Asp Lys            
           1               5                   10                         

gtt caa gcc tac tca act gct gga ggg aag gtg tgg ctg tca gta ctt        337
Val Gln Ala Tyr Ser Thr Ala Gly Gly Lys Val Trp Leu Ser Val Leu           
    15                  20                  25                            

ttc att ttc cga atc ctg ctg ctg ggg aca gcg gtt gag tca gcc tgg        385
Phe Ile Phe Arg Ile Leu Leu Leu Gly Thr Ala Val Glu Ser Ala Trp           
30                  35                  40                  45            

gga gat gag cag tct gcc ttt cgt tgt aac act cag caa cct ggt tgt        433
Gly Asp Glu Gln Ser Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys           
                50                  55                  60                

gaa aat gtc tgc tat gac aag tct ttc cca atc tct cat gtg cgc ttc        481
Glu Asn Val Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg Phe           
            65                  70                  75                    

tgg gtc ctg cag atc ata ttt gtg tct gta ccc aca ctc ttg tac ctg        529
Trp Val Leu Gln Ile Ile Phe Val Ser Val Pro Thr Leu Leu Tyr Leu           
        80                  85                  90                        

gct cat gtg ttc tat gtg atg cga aag gaa gag aaa ctg aac aag aaa        577
Ala His Val Phe Tyr Val Met Arg Lys Glu Glu Lys Leu Asn Lys Lys           
    95                  100                 105                           

gag gaa gaa ctc aag gtt gcc caa act gat ggt gtc aat gtg gac atg        625
Glu Glu Glu Leu Lys Val Ala Gln Thr Asp Gly Val Asn Val Asp Met           
110                 115                 120                 125           

cac ttg aag cag att gag ata aag aag ttc aag tac ggt att gaa gag        673
His Leu Lys Gln Ile Glu Ile Lys Lys Phe Lys Tyr Gly Ile Glu Glu           
                130                 135                 140               

cat ggt aag gtg aaa atg cga ggg ggg ttg ctg cga acc tac atc atc        721
His Gly Lys Val Lys Met Arg Gly Gly Leu Leu Arg Thr Tyr Ile Ile           
            145                 150                 155                   

agt atc ctc ttc aag tct atc ttt gag gtg gcc ttc ttg ctg atc cag        769
Ser Ile Leu Phe Lys Ser Ile Phe Glu Val Ala Phe Leu Leu Ile Gln           
        160                 165                 170                       

tgg tac atc tat gga ttc agc ttg agt gct gtt tac act tgc aaa aga        817
Trp Tyr Ile Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg           
    175                 180                 185                           

gat ccc tgc cca cat cag gtg gac tgt ttc ctc tct cgc ccc acg gag        865
Asp Pro Cys Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr Glu           
190                 195                 200                 205           

aaa acc atc ttc atc atc ttc atg ctg gtg gtg tcc ttg gtg tcc ctg        913
Lys Thr Ile Phe Ile Ile Phe Met Leu Val Val Ser Leu Val Ser Leu           
                210                 215                 220               

gcc ttg aat atc att gaa ctc ttc tat gtt ttc ttc aag ggc gtt aag        961
Ala Leu Asn Ile Ile Glu Leu Phe Tyr Val Phe Phe Lys Gly Val Lys           
            225                 230                 235                   

gat cgg gtt aag gga aag agc gac cct tac cat gcg acc agt ggt gcg       1009
Asp Arg Val Lys Gly Lys Ser Asp Pro Tyr His Ala Thr Ser Gly Ala           
        240                 245                 250                       

ctg agc cct gcc aaa gac tgt ggg tct caa aaa tat gct tat ttc aat       1057
Leu Ser Pro Ala Lys Asp Cys Gly Ser Gln Lys Tyr Ala Tyr Phe Asn           
    255                 260                 265                           

ggc tgc tcc tca cca acc gct ccc ctc tcg cct atg tct cct cct ggg       1105
Gly Cys Ser Ser Pro Thr Ala Pro Leu Ser Pro Met Ser Pro Pro Gly           
270                 275                 280                 285           

tac aag ctg gtt act ggc gac aga aac aat tct tct tgc cgc aat tac       1153
Tyr Lys Leu Val Thr Gly Asp Arg Asn Asn Ser Ser Cys Arg Asn Tyr           
                290                 295                 300               

aac aag caa gca agt gag caa aac tgg gct aat tac agt gca gaa caa       1201
Asn Lys Gln Ala Ser Glu Gln Asn Trp Ala Asn Tyr Ser Ala Glu Gln           
            305                 310                 315                   

aat cga atg ggg cag gcg gga agc acc atc tct aac tcc cat gca cag       1249
Asn Arg Met Gly Gln Ala Gly Ser Thr Ile Ser Asn Ser His Ala Gln           
        320                 325                 330                       

cct ttt gat ttc ccc gat gat aac cag aat tct aaa aaa cta gct gct       1297
Pro Phe Asp Phe Pro Asp Asp Asn Gln Asn Ser Lys Lys Leu Ala Ala           
    335                 340                 345                           

gga cat gaa tta cag cca cta gcc att gtg gac cag cga cct tca agc       1345
Gly His Glu Leu Gln Pro Leu Ala Ile Val Asp Gln Arg Pro Ser Ser           
350                 355                 360                 365           

aga gcc agc agt cgt gcc agc agc aga cct cgg cct gat gac ctg gag       1393
Arg Ala Ser Ser Arg Ala Ser Ser Arg Pro Arg Pro Asp Asp Leu Glu           
                370                 375                 380               

atc tag atacaggctt gaaagcatca agattccact caattgtgga gaagaaaaaa        1449
Ile                                                                       
                                                                          

ggtgctgtag aaagtgcacc aggtgttaat tttgatccgg tggaggtggt actcaacagc     1509

cttattcatg aggcttagaa aacacaaaga cattagaata cctaggttca ctgggggtgt     1569

atggggtaga tgggtggaga gggaggggat aagagaggtg catgttggta tttaaagtag     1629

tggattcaaa gaacttagat tataaataag agttccatta ggtgatacat agataagggc     1689

tttttctccc cgcaaacacc cctaagaatg gttctgtgta tgtgaatgag cgggtggtaa     1749

ttgtggctaa atatttttgt tttaccaaga aactgaaata attctggcca ggaataaata     1809

cttcctgaac atcttaggtc ttttcaacaa gaaaaagaca gaggattgtc cttaagtccc     1869

tgctaaaaca ttccattgtt aaaatttgca ctttgaaggt aagctttcta ggcctgaccc     1929

tccaggtgtc aatggacttg tgctactata tttttttatt cttggtatca gtttaaaatt     1989

cagacaaggc ccacagaata agattttcca tgcatttgca aatacgtata ttctttttcc     2049

atccacttgc acaatatcat taccatcact ttttcatcat tcctcagcta ctactcacat     2109

tcatttaatg gtttctgtaa acatttttaa gacagttggg atgtcactta acattttttt     2169

tttgagctaa agtcagggaa tcaagccatg cttaatattt aacaatcact tatatgtgtg     2229

tcgaagagtt tgttttgttt gtcatgtatt ggtacaagca gatacagtat aaactcacaa     2289

acacagattt gaaaataatg cacatatggt gttcaaattt gaacctttct catggatttt     2349

tgtggtgtgg gccaatatgg tgtttacatt atataattcc tgctgtggca agtaaagcac     2409

actttttttt tctcctaaaa tgtttttccc tgtgtatcct attatggata ctggttttgt     2469

taattatgat tctttatttt ctctcctttt tttaggatat agcagtaatg ctattactga     2529

aatgaatttc ctttttctga aatgtaatca ttgatgcttg aatgatagaa ttttagtact     2589

gtaaacaggc tttagtcatt aatgtgagag acttagaaaa aatgcttaga gtggactatt     2649

aaatgtgcct aaatgaattt tgcagtaact ggtattcttg ggttttccta cttaatacac     2709

agtaattcag aacttgtatt ctattatgag tttagcagtc ttttggagtg accagcaact     2769

ttgatgtttg cactaagatt ttatttggaa tgcaagagag gttgaaagag gattcagtag     2829

tacacataca actaatttat ttgaactata tgttgaagac atctaccagt ttctccaaat     2889

gcctttttta aaactcatca cagaagattg gtgaaaatgc tgagtatgac acttttcttc     2949

ttgcatgcat gtcagctaca taaacagttt tgtacaatga aaattactaa tttgtttgac     3009

attccatgtt aaactacggt catgttcagc ttcattgcat gtaatgtaga cctagtccat     3069

cagatcatgt gttctggaga gtgttcttta ttcaataaag ttttaattta gtataaacat     3129

a                                                                     3130


<210>  44
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gly Asp Trp Ser Ala Leu Gly Lys Leu Leu Asp Lys Val Gln Ala 
1               5                   10                  15      


Tyr Ser Thr Ala Gly Gly Lys Val Trp Leu Ser Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Leu Leu Gly Thr Ala Val Glu Ser Ala Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Val Pro Thr Leu Leu Tyr Leu Ala His Val 
                85                  90                  95      


Phe Tyr Val Met Arg Lys Glu Glu Lys Leu Asn Lys Lys Glu Glu Glu 
            100                 105                 110         


Leu Lys Val Ala Gln Thr Asp Gly Val Asn Val Asp Met His Leu Lys 
        115                 120                 125             


Gln Ile Glu Ile Lys Lys Phe Lys Tyr Gly Ile Glu Glu His Gly Lys 
    130                 135                 140                 


Val Lys Met Arg Gly Gly Leu Leu Arg Thr Tyr Ile Ile Ser Ile Leu 
145                 150                 155                 160 


Phe Lys Ser Ile Phe Glu Val Ala Phe Leu Leu Ile Gln Trp Tyr Ile 
                165                 170                 175     


Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg Asp Pro Cys 
            180                 185                 190         


Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Ser Leu Val Ser Leu Ala Leu Asn 
    210                 215                 220                 


Ile Ile Glu Leu Phe Tyr Val Phe Phe Lys Gly Val Lys Asp Arg Val 
225                 230                 235                 240 


Lys Gly Lys Ser Asp Pro Tyr His Ala Thr Ser Gly Ala Leu Ser Pro 
                245                 250                 255     


Ala Lys Asp Cys Gly Ser Gln Lys Tyr Ala Tyr Phe Asn Gly Cys Ser 
            260                 265                 270         


Ser Pro Thr Ala Pro Leu Ser Pro Met Ser Pro Pro Gly Tyr Lys Leu 
        275                 280                 285             


Val Thr Gly Asp Arg Asn Asn Ser Ser Cys Arg Asn Tyr Asn Lys Gln 
    290                 295                 300                 


Ala Ser Glu Gln Asn Trp Ala Asn Tyr Ser Ala Glu Gln Asn Arg Met 
305                 310                 315                 320 


Gly Gln Ala Gly Ser Thr Ile Ser Asn Ser His Ala Gln Pro Phe Asp 
                325                 330                 335     


Phe Pro Asp Asp Asn Gln Asn Ser Lys Lys Leu Ala Ala Gly His Glu 
            340                 345                 350         


Leu Gln Pro Leu Ala Ile Val Asp Gln Arg Pro Ser Ser Arg Ala Ser 
        355                 360                 365             


Ser Arg Ala Ser Ser Arg Pro Arg Pro Asp Asp Leu Glu Ile 
    370                 375                 380         


<210>  45
<211>  4101
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (350)..(1726)

<400>  45
gtgcttgcgg acttcccgcc agcgccgagc ggccggcttc tcgggccaag tggggagcga       60

gcgggagggc gggcaggtgg ccccgggccg ccgcgcccgc gccttggctc tgcccccggg      120

agccgagcaa gccgctgctc cctcgtggtg tgagggcggt gatgtttttc ctcccaccca      180

cttttgagtt ccccctcccc cctcgcgcgc actctagctc tcgccacaac ctgccagccc      240

cagacctcgg acgagagcgc cccggggagc tcggagcgcg tgcacgcgtg gcagacggag      300

aaggccagtg cccagcttga aggttctgtc accttttgca gtggtccaa atg aga aaa      358
                                                      Met Arg Lys         
                                                      1                   

aag tgg aaa atg gga ggc atg aaa tac atc ttt tcg ttg ttg ttc ttt        406
Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu Leu Phe Phe           
    5                   10                  15                            

ctt ttg cta gaa gga ggc aaa aca gag caa gta aaa cat tca gag aca        454
Leu Leu Leu Glu Gly Gly Lys Thr Glu Gln Val Lys His Ser Glu Thr           
20                  25                  30                  35            

tat tgc atg ttt caa gac aag aag tac aga gtg ggt gag aga tgg cat        502
Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu Arg Trp His           
                40                  45                  50                

cct tac ctg gaa cct tat ggg ttg gtt tac tgc gtg aac tgc atc tgc        550
Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn Cys Ile Cys           
            55                  60                  65                    

tca gag aat ggg aat gtg ctt tgc agc cga gtc aga tgt cca aat gtt        598
Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys Pro Asn Val           
        70                  75                  80                        

cat tgc ctt tct cct gtg cat att cct cat ctg tgc tgc cct cgc tgc        646
His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys Pro Arg Cys           
    85                  90                  95                            

cca gaa gac tcc tta ccc cca gtg aac aat aag gtg acc agc aag tct        694
Pro Glu Asp Ser Leu Pro Pro Val Asn Asn Lys Val Thr Ser Lys Ser           
100                 105                 110                 115           

tgc gag tac aat ggg aca act tac caa cat gga gag ctg ttc gta gct        742
Cys Glu Tyr Asn Gly Thr Thr Tyr Gln His Gly Glu Leu Phe Val Ala           
                120                 125                 130               

gaa ggg ctc ttt cag aat cgg caa ccc aat caa tgc acc cag tgc agc        790
Glu Gly Leu Phe Gln Asn Arg Gln Pro Asn Gln Cys Thr Gln Cys Ser           
            135                 140                 145                   

tgt tcg gag gga aac gtg tat tgt ggt ctc aag act tgc ccc aaa tta        838
Cys Ser Glu Gly Asn Val Tyr Cys Gly Leu Lys Thr Cys Pro Lys Leu           
        150                 155                 160                       

acc tgt gcc ttc cca gtc tct gtt cca gat tcc tgc tgc cgg gta tgc        886
Thr Cys Ala Phe Pro Val Ser Val Pro Asp Ser Cys Cys Arg Val Cys           
    165                 170                 175                           

aga gga gat gga gaa ctg tca tgg gaa cat tct gat ggt gat atc ttc        934
Arg Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly Asp Ile Phe           
180                 185                 190                 195           

cgg caa cct gcc aac aga gaa gca aga cat tct tac cac cgc tct cac        982
Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His Arg Ser His           
                200                 205                 210               

tat gat cct cca cca agc cga cag gct gga ggt ctg tcc cgc ttt cct       1030
Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser Arg Phe Pro           
            215                 220                 225                   

ggg gcc aga agt cac cgg gga gct ctt atg gat tcc cag caa gca tca       1078
Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln Gln Ala Ser           
        230                 235                 240                       

gga acc att gtg caa att gtc atc aat aac aaa cac aag cat gga caa       1126
Gly Thr Ile Val Gln Ile Val Ile Asn Asn Lys His Lys His Gly Gln           
    245                 250                 255                           

gtg tgt gtt tcc aat gga aag acc tat tct cat ggc gag tcc tgg cac       1174
Val Cys Val Ser Asn Gly Lys Thr Tyr Ser His Gly Glu Ser Trp His           
260                 265                 270                 275           

cca aac ctc cgg gca ttt ggc att gtg gag tgt gtg cta tgt act tgt       1222
Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu Cys Thr Cys           
                280                 285                 290               

aat gtc acc aag caa gag tgt aag aaa atc cac tgc ccc aat cga tac       1270
Asn Val Thr Lys Gln Glu Cys Lys Lys Ile His Cys Pro Asn Arg Tyr           
            295                 300                 305                   

ccc tgc aag tat cct caa aaa ata gac gga aaa tgc tgc aag gtg tgt       1318
Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys Lys Val Cys           
        310                 315                 320                       

cca ggt aaa aaa gca aaa gaa gaa ctt cca ggc caa agc ttt gac aat       1366
Pro Gly Lys Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser Phe Asp Asn           
    325                 330                 335                           

aaa ggc tac ttc tgc ggg gaa gaa acg atg cct gtg tat gag tct gta       1414
Lys Gly Tyr Phe Cys Gly Glu Glu Thr Met Pro Val Tyr Glu Ser Val           
340                 345                 350                 355           

ttc atg gag gat ggg gag aca acc aga aaa ata gca ctg gag act gag       1462
Phe Met Glu Asp Gly Glu Thr Thr Arg Lys Ile Ala Leu Glu Thr Glu           
                360                 365                 370               

aga cca cct cag gta gag gtc cac gtt tgg act att cga aag ggc att       1510
Arg Pro Pro Gln Val Glu Val His Val Trp Thr Ile Arg Lys Gly Ile           
            375                 380                 385                   

ctc cag cac ttc cat att gag aag atc tcc aag agg atg ttt gag gag       1558
Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met Phe Glu Glu           
        390                 395                 400                       

ctt cct cac ttc aag ctg gtg acc aga aca acc ctg agc cag tgg aag       1606
Leu Pro His Phe Lys Leu Val Thr Arg Thr Thr Leu Ser Gln Trp Lys           
    405                 410                 415                           

atc ttc acc gaa gga gaa gct cag atc agc cag atg tgt tca agt cgt       1654
Ile Phe Thr Glu Gly Glu Ala Gln Ile Ser Gln Met Cys Ser Ser Arg           
420                 425                 430                 435           

gta tgc aga aca gag ctt gaa gat tta gtc aag gtt ttg tac ctg gag       1702
Val Cys Arg Thr Glu Leu Glu Asp Leu Val Lys Val Leu Tyr Leu Glu           
                440                 445                 450               

aga tct gaa aag ggc cac tgt tag gcaagacaga cagtattgga tagggtaaag      1756
Arg Ser Glu Lys Gly His Cys                                               
            455                                                           

caagaaaact caagctgcag ctggactgca ggcttatttt gcttaagtca acagtgccct     1816

aaaactccaa actcaaatgc agtcaattat tcacgccatg cacagcataa tttgctcctt     1876

tgtgtggagt ggtgtgtcag cccttgaaca tctcctccaa agagactaga agagtcttaa     1936

attatatgtg ggaggaggag ggatagaaca tcacaacact gctctagttt cttggagaat     1996

cacatttctt tacaggttaa agacaaacaa gaccccaggg tttttatcta gaaagttatt     2056

caagtgaaag aaagagaagg gaattgctta gtaggagttc tgcagtatag aacaattact     2116

tgtatgaaat tatacctttg aattttagaa tgtcatgtgt tcttttaaaa aaattagctc     2176

cccatcctcc ctcctcactc cctccctccc tccttctctc tctctctctc tctccctccc     2236

tctctcacag acacacacac acacacacac acacacacac acacgcacgt ccacactcac     2296

attaaacgaa agctttattt gaagcaaagc tagccaagat tctacgttac ttttcccttg     2356

actggatccc aagtagcttg gaagtttttg tgcccaggag agtaaataac tgtgaacaag     2416

aggctctgcc cttaggtctt tgtggctgtt taagtcacca acaatagagt cagggtaaag     2476

aataaaaaca ctttcatagc ctcattcatt cacttagaag tggtaataat ttttccctaa     2536

tgataccact tttcttttcc ccctgtacct atgggacttc cagaaagaag ttaaattgag     2596

taaaatcatc agaaactgaa tccatgtaag aaaaaataat tgttgaagaa agaagttgat     2656

agaattcaaa aaggccatct ttttgctttc acatcaataa aatttaccaa gtaatagatc     2716

agtactcact aatatttttg agaccatagt tgtctggtca gaaaaattat attaaattag     2776

taaattctag aagctcttta aaagggaagt tttccttctt ctccaattat aggagttgat     2836

ttttactttg caaagtggct cggtcctcat gagcatctgc atgttgactc ttcagttaag     2896

aaaattgttg ttcatttagg gaggtggata ttctgatgaa gatctttatc ctaaaccttc     2956

ctactatcct tgtcttattc atcaagcaga tattttagtc aagaattcca gagaaggctg     3016

ctcctaaaat gtctacttgc agcccaatac cagagcataa actatccatt ctggggtctg     3076

gctttagaaa tcatctttgt gggaagacct aattcttcac agcaaggatc tcaggcatgc     3136

cttctagatt tgttccctct gaggggcagg aatgaactgt agaaatgttt taaggaccca     3196

gaaaccccat atgtctcatt ccatgactat aggtgagaga attctttcct aagagggttt     3256

gataccaata ggggaaaatg taaaatgttc agtctttatg acaacctggc ataaaggagt     3316

caattcttat gaaagagaca caagggcctt atggccaggg tttcttggga caagactctc     3376

accagcacat cacacacgtt ctccttggaa gagagaagca gtacatcccg gttgagaggt     3436

cacaaagcat tagtttgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     3496

gtggtaaagg ggggaaggtg ttatgcggct gctccctccg tcccagaggt ggcagtgatt     3556

ccataatgtg gagactagta actagatcct aaggcaaaga ggtgtttctc cttctggatg     3616

attcatccca aagccttccc acccaggtgt tctctgaaag cttagcctta agagaacacg     3676

cagagagttt ccctagatat actcctgcct ccaggtgctg ggacacacct ttgcaaaatg     3736

ctgtgggaag caggagctgg ggagctgtgt taagtcaaag tagaaaccct ccagtgtttg     3796

gtgttgtgta gagaatagga catagggtaa agaggccaag ctgcctgtag ttagtagaga     3856

agaatggatg tggttcttct tgtgtattta tttgtatcat aaacacttgg aacaacaaag     3916

accataagca tcatttagca gttgtagcca ttttctagtt aactcatgta aacaagtaag     3976

agtaacataa cagtattacc ctttcactgt tctcacagga catgtaccta attatggtac     4036

ttatttatgt agtcactgta tttctggatt tttaaattaa taaaaaagtt aattttgaaa     4096

aatca                                                                 4101


<210>  46
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Thr Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Thr Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Glu Asp Ser Leu Pro Pro Val Asn Asn Lys Val Thr 
            100                 105                 110         


Ser Lys Ser Cys Glu Tyr Asn Gly Thr Thr Tyr Gln His Gly Glu Leu 
        115                 120                 125             


Phe Val Ala Glu Gly Leu Phe Gln Asn Arg Gln Pro Asn Gln Cys Thr 
    130                 135                 140                 


Gln Cys Ser Cys Ser Glu Gly Asn Val Tyr Cys Gly Leu Lys Thr Cys 
145                 150                 155                 160 


Pro Lys Leu Thr Cys Ala Phe Pro Val Ser Val Pro Asp Ser Cys Cys 
                165                 170                 175     


Arg Val Cys Arg Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly 
            180                 185                 190         


Asp Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His 
        195                 200                 205             


Arg Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser 
    210                 215                 220                 


Arg Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln 
225                 230                 235                 240 


Gln Ala Ser Gly Thr Ile Val Gln Ile Val Ile Asn Asn Lys His Lys 
                245                 250                 255     


His Gly Gln Val Cys Val Ser Asn Gly Lys Thr Tyr Ser His Gly Glu 
            260                 265                 270         


Ser Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu 
        275                 280                 285             


Cys Thr Cys Asn Val Thr Lys Gln Glu Cys Lys Lys Ile His Cys Pro 
    290                 295                 300                 


Asn Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys 
305                 310                 315                 320 


Lys Val Cys Pro Gly Lys Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser 
                325                 330                 335     


Phe Asp Asn Lys Gly Tyr Phe Cys Gly Glu Glu Thr Met Pro Val Tyr 
            340                 345                 350         


Glu Ser Val Phe Met Glu Asp Gly Glu Thr Thr Arg Lys Ile Ala Leu 
        355                 360                 365             


Glu Thr Glu Arg Pro Pro Gln Val Glu Val His Val Trp Thr Ile Arg 
    370                 375                 380                 


Lys Gly Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met 
385                 390                 395                 400 


Phe Glu Glu Leu Pro His Phe Lys Leu Val Thr Arg Thr Thr Leu Ser 
                405                 410                 415     


Gln Trp Lys Ile Phe Thr Glu Gly Glu Ala Gln Ile Ser Gln Met Cys 
            420                 425                 430         


Ser Ser Arg Val Cys Arg Thr Glu Leu Glu Asp Leu Val Lys Val Leu 
        435                 440                 445             


Tyr Leu Glu Arg Ser Glu Lys Gly His Cys 
    450                 455             


<210>  47
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  47
ctcacctcac agacactcct ctctggatcc tccagagcta taaagacggg ccttccacca       60

ccagacaggc gcactctacc accatgaatc cactcctgat ccttgccttt gtgggagctg      120

ctgttgctgt cccctttgat gatgatgaca agatcgttgg gggctacacc tgtgaggaga      180

attctgtccc ctaccaggtg tccttgaatt ctggctccca cttctgcggt ggctccctca      240

tcagcgaaca gtgggtggtg tcagcaggtc actgctacaa gccccacatc caggtgagac      300

tgggagagca caatatcgaa gtcctggagg ggaatgagca gttcatcaat gcagccaaga      360

tcatccgcca ccccaaatac aacaggatta ttctgaacaa tgacatcatg ctgatcaagc      420

tctccacacc tgccgtcatc aatgcccatg tgtccaccat ctctctgccc actgcccctc      480

cagctgctgg caccgagtgc cttatctccg gctggggcaa taccctgagc tctggggccg      540

actacccaga tgagctgcag tgcctggacg ctcctgtgct gacccaggct aagtgtaaag      600

cctcctaccc tttaaagatt accagcaaca tgttctgtgt gggcttcctt gagggaggca      660

aggattcctg ccagggtgac tctggtggcc ctgtggtctg caatggacag cttcaaggaa      720

ttgtctcctg gggctatggc tgtgcccaga agagaaggcc tggagtctac accaaggtct      780

acaactatgt ggactggatt aaggacacca tagctgccaa cagctaaagc ccctggtcac      840

tctgcagtct ctataccaat aaa                                              863


<210>  48
<211>  2649
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (246)..(827)

<400>  48
ctataaagtt ctcgctgccc cggaggctat gctactgcga ggagccggcg cagggtggcc       60

cgggaggggt gagcagggtg ccgctggctg ctggggtctg caggtcaccg agtccccagg      120

agaggggact cctaagaagc cacctgcctg tgtttacccg gcagcgagcg cgcaggcccc      180

cgcgaactcc tggcagcgct caggaaaggc cgttgcgcct cgcgaaggaa acagagccgt      240

tgacc atg gtt gca act ggc agt ttg agc agc aag aac ccg gcc agc att      290
      Met Val Ala Thr Gly Ser Leu Ser Ser Lys Asn Pro Ala Ser Ile         
      1               5                   10                  15          

tca gaa ttg ctg gac tgt ggc tat cac cca gag agc ctg cta agt gat        338
Ser Glu Leu Leu Asp Cys Gly Tyr His Pro Glu Ser Leu Leu Ser Asp           
                20                  25                  30                

ttt gac tac tgg gat tat gtt gtt cct gaa ccc aac ctc aac gag gta        386
Phe Asp Tyr Trp Asp Tyr Val Val Pro Glu Pro Asn Leu Asn Glu Val           
            35                  40                  45                    

ata ttt gag gaa tca act tgc cag aat ttg gtt aaa atg ctg gag aac        434
Ile Phe Glu Glu Ser Thr Cys Gln Asn Leu Val Lys Met Leu Glu Asn           
        50                  55                  60                        

tgt ctg tcc aaa tca aag caa act aaa ctt ggt tgc tca aag gtc ctt        482
Cys Leu Ser Lys Ser Lys Gln Thr Lys Leu Gly Cys Ser Lys Val Leu           
    65                  70                  75                            

gtc cct gag aaa ctg acc cag aga att gct caa gat gtc ctg cgg ctt        530
Val Pro Glu Lys Leu Thr Gln Arg Ile Ala Gln Asp Val Leu Arg Leu           
80                  85                  90                  95            

tcc tca acg gag ccc tgc ggc ttg cga ggt tgt gtt atg cac gtg aac        578
Ser Ser Thr Glu Pro Cys Gly Leu Arg Gly Cys Val Met His Val Asn           
                100                 105                 110               

ttg gaa att gaa aat gta tgt aaa aag ctg gat agg att gtg tgt gat        626
Leu Glu Ile Glu Asn Val Cys Lys Lys Leu Asp Arg Ile Val Cys Asp           
            115                 120                 125                   

tct agc gtc gta cct act ttt gag ctt aca ctt gtg ttt aag cag gag        674
Ser Ser Val Val Pro Thr Phe Glu Leu Thr Leu Val Phe Lys Gln Glu           
        130                 135                 140                       

aac tgc tca tgg act agc ttc agg gac ttt ttc ttt agt aga ggt cgc        722
Asn Cys Ser Trp Thr Ser Phe Arg Asp Phe Phe Phe Ser Arg Gly Arg           
    145                 150                 155                           

ttc tcc tct ggt ttc agg aga act ctg atc ctc agc tca gga ttt cga        770
Phe Ser Ser Gly Phe Arg Arg Thr Leu Ile Leu Ser Ser Gly Phe Arg           
160                 165                 170                 175           

ctt gtt aag aaa aaa ctt tac tca ctg att gga aca aca gtg att gaa        818
Leu Val Lys Lys Lys Leu Tyr Ser Leu Ile Gly Thr Thr Val Ile Glu           
                180                 185                 190               

ggg tcc taa aaagggaaaa tatataaaga ttatttcatg attgggtagt                867
Gly Ser                                                                   
                                                                          

aaaactattc agctagtcag ctaaagtcat ttgtagtttg ccccacctgc cctaaataag      927

aaaccccaaa tgtagtctct tttctttctg tgtttcacat tcatagcaac tgcagctaac      987

aggctgattt tctggccttt ggagaagtga ttcaaaatag tgtagatttt ctgcatagat     1047

cccatttttg tacagaattg aatgggatgg aataggtaag caaaagtaga agcccatttg     1107

agttttacat ttgattccac aatttggttt caggtaggct tggtaataga ctatataaac     1167

cagatttgcc tattttgatt ttcatatggc ttttttttct gtaagttttc agaggatttt     1227

ttaaatcaca gaatcatact aaatgatatt tagcctatca aaacttccaa aagcccacac     1287

caccagttcc tgactcaaat ttgaagggtt tttagacagg agggtaggat taagtaggtg     1347

agtttaatta aagcttaacc ctaggtaaga gtaaatgaga aatattacgg caataatgga     1407

actgcttcac tgtttcttgg tgacttcctc actctaatgt tttaaagagg caacaaaagc     1467

ttgtggtgcc atttcagtaa ccacggtgtt gttttagatg cctttataag ctcagtttcc     1527

cctgttctta agtgttgaat actgtcttta aactagaaaa atgcaaaata ttgaactgat     1587

atttttgtgt gtagttgatt actcttccat tgagtgaatg atgaatacct gtgaggatag     1647

gaaattagtt ctgagatcta gtccctctct gattcactta gtaatctatc ctcttttcag     1707

tattacatgt gcttaatctc agatgaacca tttcaccatg gcagtgttat ctcatctctg     1767

ggcttttctg ggaattgaag tatctctcct taaccccaat tgtcaagggt agtagctgta     1827

tactaccact ttgaattatt gaaacgggtc aatttacgaa gtctgcattg gctatggaga     1887

tatggtttat agtacagcct agagaatgaa actcaccgtc cagataacca tgcatgcacc     1947

cagatttttt ccaccttgga tacctgtcac tagggaataa taaaggcctg attttttgtc     2007

ttattccaac taagtagatc attatctctt tcctttttta tgttaatgag agaatttagc     2067

ctccactcaa caatgttcaa ttcagcaagg ctttcatatc cttgctgtgg gtcgtggata     2127

aggagcttat tcaggtttcc tgccctagct attagctcca cttcacatgc tggagaccgg     2187

cgtagggaca gatgtattca tcctggtgtt actgaaaaac aggtgtgatc ctgttactga     2247

tactataagt gacctaaaat gtcactgttc aaattagcca gtgttctaac aaactaaact     2307

cttcaaatgc ttggaaagat actacaaagc caatctttat agaattgggc caagataaat     2367

ctatgttgtt ttgcatggct attgttaagc tccaaaggtt cactgtgttt ctgccgctgt     2427

cctggagttg tcaccactga ctgggcaagg cttcttgggc atggatgtag aactgttgtc     2487

cttttcccac taacagttat ctttgactct cttgcctgtt atgcttacaa aatggtgatg     2547

gcttatggaa ggctgttaaa ttaatattcc tgttaaagga aattaaagtt tgtctatttt     2607

tgacaataaa acattatata tttttaaaaa aaaaaaaaaa aa                        2649


<210>  49
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Val Ala Thr Gly Ser Leu Ser Ser Lys Asn Pro Ala Ser Ile Ser 
1               5                   10                  15      


Glu Leu Leu Asp Cys Gly Tyr His Pro Glu Ser Leu Leu Ser Asp Phe 
            20                  25                  30          


Asp Tyr Trp Asp Tyr Val Val Pro Glu Pro Asn Leu Asn Glu Val Ile 
        35                  40                  45              


Phe Glu Glu Ser Thr Cys Gln Asn Leu Val Lys Met Leu Glu Asn Cys 
    50                  55                  60                  


Leu Ser Lys Ser Lys Gln Thr Lys Leu Gly Cys Ser Lys Val Leu Val 
65                  70                  75                  80  


Pro Glu Lys Leu Thr Gln Arg Ile Ala Gln Asp Val Leu Arg Leu Ser 
                85                  90                  95      


Ser Thr Glu Pro Cys Gly Leu Arg Gly Cys Val Met His Val Asn Leu 
            100                 105                 110         


Glu Ile Glu Asn Val Cys Lys Lys Leu Asp Arg Ile Val Cys Asp Ser 
        115                 120                 125             


Ser Val Val Pro Thr Phe Glu Leu Thr Leu Val Phe Lys Gln Glu Asn 
    130                 135                 140                 


Cys Ser Trp Thr Ser Phe Arg Asp Phe Phe Phe Ser Arg Gly Arg Phe 
145                 150                 155                 160 


Ser Ser Gly Phe Arg Arg Thr Leu Ile Leu Ser Ser Gly Phe Arg Leu 
                165                 170                 175     


Val Lys Lys Lys Leu Tyr Ser Leu Ile Gly Thr Thr Val Ile Glu Gly 
            180                 185                 190         


Ser 
    


<210>  50
<211>  7114
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (633)..(2300)

<400>  50
gcctccagtg actgtctcca ggatttctct cttcctattt caggaggact ctcacaggct       60

cccacagcct gtgttaagct gaggtttccc ctagatctcg tatatcccca acacatacct      120

ccacgcacac acatccccaa gaacctcgag ctcacaccaa cagacacacg cgcgcataca      180

cactcgctct cgcttgtcca tctccctccc gggggagccg gcgcgcgctc ccacctttgc      240

cgcacactcc ggcgagccga gcccgcagcg ctccaggatt ctgcggctcg gaactcggat      300

tgcagctctg aacccccatg gtggtttttt aaacacttct tttccttctc ttcctcgttt      360

tgattgcacc gtttccatct gggggctaga ggagcaaggc agcagccttc ccagccagcc      420

cttgttggct tgccatcgtc catctggctt ataaaagttt gctgagcgca gtccagaggg      480

ctgcgctgct cgtcccctcg gctggcagaa gggggtgacg ctgggcagcg gcgaggagcg      540

cgccgctgcc tctggcgggc tttcggcttg aggggcaagg tgaagagcgc accggccgtg      600

gggtttaccg agctggattt gtatgttgca cc atg cct tct tgg atc ggg gct        653
                                    Met Pro Ser Trp Ile Gly Ala           
                                    1               5                     

gtg att ctt ccc ctc ttg ggg ctg ctg ctc tcc ctc ccc gcc ggg gcg        701
Val Ile Leu Pro Leu Leu Gly Leu Leu Leu Ser Leu Pro Ala Gly Ala           
        10                  15                  20                        

gat gtg aag gct cgg agc tgc gga gag gtc cgc cag gcg tac ggt gcc        749
Asp Val Lys Ala Arg Ser Cys Gly Glu Val Arg Gln Ala Tyr Gly Ala           
    25                  30                  35                            

aag gga ttc agc ctg gcg gac atc ccc tac cag gag atc gca ggg gaa        797
Lys Gly Phe Ser Leu Ala Asp Ile Pro Tyr Gln Glu Ile Ala Gly Glu           
40                  45                  50                  55            

cac tta aga atc tgt cct cag gaa tat aca tgc tgc acc aca gaa atg        845
His Leu Arg Ile Cys Pro Gln Glu Tyr Thr Cys Cys Thr Thr Glu Met           
                60                  65                  70                

gaa gac aag tta agc caa caa agc aaa ctc gaa ttt gaa aac ctt gtg        893
Glu Asp Lys Leu Ser Gln Gln Ser Lys Leu Glu Phe Glu Asn Leu Val           
            75                  80                  85                    

gaa gag aca agc cat ttt gtg cgc acc act ttt gtg tcc agg cat aag        941
Glu Glu Thr Ser His Phe Val Arg Thr Thr Phe Val Ser Arg His Lys           
        90                  95                  100                       

aaa ttt gac gaa ttt ttc cga gag ctc ctg gag aat gca gaa aag tca        989
Lys Phe Asp Glu Phe Phe Arg Glu Leu Leu Glu Asn Ala Glu Lys Ser           
    105                 110                 115                           

cta aat gat atg ttt gta cgg acc tat ggc atg ctg tac atg cag aat       1037
Leu Asn Asp Met Phe Val Arg Thr Tyr Gly Met Leu Tyr Met Gln Asn           
120                 125                 130                 135           

tca gaa gtc ttc cag gac ctc ttc aca gag ctg aaa agg tac tac act       1085
Ser Glu Val Phe Gln Asp Leu Phe Thr Glu Leu Lys Arg Tyr Tyr Thr           
                140                 145                 150               

ggg ggt aat gtg aat ctg gag gaa atg ctc aat gac ttt tgg gct cgg       1133
Gly Gly Asn Val Asn Leu Glu Glu Met Leu Asn Asp Phe Trp Ala Arg           
            155                 160                 165                   

ctc ctg gaa cgg atg ttt cag ctg ata aac cct cag tat cac ttc agt       1181
Leu Leu Glu Arg Met Phe Gln Leu Ile Asn Pro Gln Tyr His Phe Ser           
        170                 175                 180                       

gaa gac tac ctg gaa tgt gtg agc aaa tac act gac cag ctc aag cca       1229
Glu Asp Tyr Leu Glu Cys Val Ser Lys Tyr Thr Asp Gln Leu Lys Pro           
    185                 190                 195                           

ttt gga gac gtg ccc cgg aaa ctg aag att cag gtt acc cgc gcc ttc       1277
Phe Gly Asp Val Pro Arg Lys Leu Lys Ile Gln Val Thr Arg Ala Phe           
200                 205                 210                 215           

att gct gcc agg acc ttt gtc cag ggg ctg act gtg ggc aga gaa gtt       1325
Ile Ala Ala Arg Thr Phe Val Gln Gly Leu Thr Val Gly Arg Glu Val           
                220                 225                 230               

gca aac cga gtt tcc aag gtc agc cca acc cca ggg tgt atc cgt gcc       1373
Ala Asn Arg Val Ser Lys Val Ser Pro Thr Pro Gly Cys Ile Arg Ala           
            235                 240                 245                   

ctc atg aag atg ctg tac tgc cca tac tgt cgg ggg ctt ccc act gtg       1421
Leu Met Lys Met Leu Tyr Cys Pro Tyr Cys Arg Gly Leu Pro Thr Val           
        250                 255                 260                       

agg ccc tgc aac aac tac tgt ctc aac gtc atg aag ggc tgc ttg gca       1469
Arg Pro Cys Asn Asn Tyr Cys Leu Asn Val Met Lys Gly Cys Leu Ala           
    265                 270                 275                           

aat cag gct gac ctc gac aca gag tgg aat ctg ttt ata gat gca atg       1517
Asn Gln Ala Asp Leu Asp Thr Glu Trp Asn Leu Phe Ile Asp Ala Met           
280                 285                 290                 295           

ctc ttg gtg gca gag cga ctg gag ggg cca ttc aac att gag tcg gtc       1565
Leu Leu Val Ala Glu Arg Leu Glu Gly Pro Phe Asn Ile Glu Ser Val           
                300                 305                 310               

atg gac ccg ata gat gtc aag att tct gaa gcc att atg aac atg caa       1613
Met Asp Pro Ile Asp Val Lys Ile Ser Glu Ala Ile Met Asn Met Gln           
            315                 320                 325                   

gaa aac agc atg cag gtg tct gca aag gtc ttt cag gga tgt ggt cag       1661
Glu Asn Ser Met Gln Val Ser Ala Lys Val Phe Gln Gly Cys Gly Gln           
        330                 335                 340                       

ccc aaa cct gct cca gcc ctc aga tct gcc cgc tca gct cct gaa aat       1709
Pro Lys Pro Ala Pro Ala Leu Arg Ser Ala Arg Ser Ala Pro Glu Asn           
    345                 350                 355                           

ttt aat aca cgt ttc agg ccc tac aat cct gag gaa aga cca aca act       1757
Phe Asn Thr Arg Phe Arg Pro Tyr Asn Pro Glu Glu Arg Pro Thr Thr           
360                 365                 370                 375           

gct gca ggc aca agc ttg gac cgg ctg gtc aca gac ata aaa gag aaa       1805
Ala Ala Gly Thr Ser Leu Asp Arg Leu Val Thr Asp Ile Lys Glu Lys           
                380                 385                 390               

ttg aag ctc tct aaa aag gtc tgg tca gca tta ccc tac act atc tgc       1853
Leu Lys Leu Ser Lys Lys Val Trp Ser Ala Leu Pro Tyr Thr Ile Cys           
            395                 400                 405                   

aag gac gag agc gtg aca gcg ggc acg tcc aac gag gag gaa tgc tgg       1901
Lys Asp Glu Ser Val Thr Ala Gly Thr Ser Asn Glu Glu Glu Cys Trp           
        410                 415                 420                       

aac ggg cac agc aaa gcc aga tac ttg cct gag atc atg aat gat ggg       1949
Asn Gly His Ser Lys Ala Arg Tyr Leu Pro Glu Ile Met Asn Asp Gly           
    425                 430                 435                           

ctc acc aac cag atc aac aat ccc gag gtg gat gtg gac atc act cgg       1997
Leu Thr Asn Gln Ile Asn Asn Pro Glu Val Asp Val Asp Ile Thr Arg           
440                 445                 450                 455           

cct gac act ttc atc aga cag cag att atg gct ctc cgt gtg atg acc       2045
Pro Asp Thr Phe Ile Arg Gln Gln Ile Met Ala Leu Arg Val Met Thr           
                460                 465                 470               

aac aaa cta aaa aac gcc tac aat ggc aat gat gtc aat ttc cag gac       2093
Asn Lys Leu Lys Asn Ala Tyr Asn Gly Asn Asp Val Asn Phe Gln Asp           
            475                 480                 485                   

aca agt gat gaa tcc agt ggc tca ggg agt ggc agt ggg tgc atg gat       2141
Thr Ser Asp Glu Ser Ser Gly Ser Gly Ser Gly Ser Gly Cys Met Asp           
        490                 495                 500                       

gac gtg tgt ccc acg gag ttt gag ttt gtc acc aca gag gcc ccc gca       2189
Asp Val Cys Pro Thr Glu Phe Glu Phe Val Thr Thr Glu Ala Pro Ala           
    505                 510                 515                           

gtg gat ccc gac cgg aga gag gtg gac tct tct gca gcc cag cgt ggc       2237
Val Asp Pro Asp Arg Arg Glu Val Asp Ser Ser Ala Ala Gln Arg Gly           
520                 525                 530                 535           

cac tcc ctg ctc tcc tgg tct ctc acc tgc att gtc ctg gca ctg cag       2285
His Ser Leu Leu Ser Trp Ser Leu Thr Cys Ile Val Leu Ala Leu Gln           
                540                 545                 550               

aga ctg tgc aga taa tcttgggttt ttggtcagat gaaactgcat tttagctatc       2340
Arg Leu Cys Arg                                                           
            555                                                           

tgaatggcca actcacttct tttcttacac tcttggacaa tggaccatgc cacaaaaact     2400

taccgttttc tatgagaaga gagcagtaat gcaatctgcc tccctttttg ttttcccaaa     2460

gagtaccggg tgccagactg aactgcttcc tctttccttc agctatctgt ggggaccttg     2520

tttattctag agagaattct tactcaaatt tttcgtacca ggagattttc ttaccttcat     2580

ttgcttttat gctgcagaag taaaggaatc tcacgttgtg agggtttttt ttttctcatt     2640

taaaataaaa aaggaagaaa gaaaataatt ttccttgtaa aatcgggcca aaccccaaga     2700

cagctacatt ttcaacaaaa aagcaaacag agaaaaataa atgaacttta acactgtaag     2760

ttcagcattg acagccaact tccagtgtaa gcttttttgt gacaaatccg ggtttaaaaa     2820

tgcttatggg gagaaagctt aaagtttgtt ctaaatgtag tgaaaatgca ctgttgtctt     2880

ggaggtatca tcttgcactc taaccaaaca acaccaaatt aatctggagg tactgatact     2940

aaatttggaa tcccgtcttt aatatgagaa cacaaattac tacaactcag tacctctgtc     3000

ttactctgcc caatttcaat ttagtaatgg caccattatt cttaattccc ttaatgtctg     3060

tccgctgtat ccaattggca cagattttcc ccttcatctt caattactag tagctacccc     3120

catcaattca ccttcctcaa gagtctcaat tgaaaataat ctttgatgat acaatctctg     3180

cttttgccac aggtttgaca ttaactagac gtttctgccc ctgtgctcat taccctccca     3240

aaacaatagt ttttttaatg aattgaaaca caattagatc cattcctgag ttttcatttt     3300

taactattta ctttgtgtca gttggtttct gcatcacaag ggcattctct tacaaaacaa     3360

ctcacaacag aaaaaaaaag tcaagacaaa aaatatatat atatagtatt gacatggaga     3420

tttctttcac ttttttagtc ttagtatgat catctatttt tatatctatg tatatataaa     3480

tcacagattt taacttctta attccaagct cagggttgac acacctttgt aagaaaatgt     3540

tttgtcaacc agctcttctt gttttgtgct gctcaaagaa gggattcctc agtgatcggt     3600

gagcaccaag aatcaagaaa gagaactttt tatgtatcta actgtccatt tattaaaaat     3660

ttgccagggc acacccttct gcatgagtgt gcttcagcct gggtgctcca gactacacca     3720

aactcatggg atgagccatt ggtgtgcagg gctttaccgg tgatggaaac tgtatgtgta     3780

aagaatgtta ttcatgaaaa accattgctt tcatgtaaaa caccttcggc ctaggattcc     3840

tgcctggcac ttggatacat tacctaactc aataggccag tttagagcca cagcctaacc     3900

tgttcaccaa gtaggccaaa gccaggcctt tcgctccccc tgacagagag aagcaaaata     3960

aacccaactg ggggctttat gaatacagtt ggctatccat atgtttctta gtttttatga     4020

tgcatctgga gtagggaaaa gtaatgtttc aagacaccat agtaggccag ttacatttta     4080

attaactcat cgacagtatt gacacgtaaa tggtattttt caatctgttc tcatcaaaat     4140

taaaattagt tattgattta gtcatcacat ttaagtagaa cacatgtggc acaatagtat     4200

taagtatatt tgagcacttt tgcaagacag aaagtattta caagcatcta ttgctacttt     4260

atgcctaatg aaatataaaa tgtaggatga tgagagactt tgtggcattc tttcatttaa     4320

acctttatga aattaaccat ctagttcatc attacatact cctagaaaac catccatttc     4380

actgcccaca ttttggcttc ctaccacaaa ttccacataa gacttctcta tgaaggacca     4440

gtcatttaca ttgctcattt cattctgtgt tcagaagtca gtattgtctt tctccaataa     4500

ttaaggtgca atacaaatta aatcaacctt gattttccag actatttgaa taataacttg     4560

cttttatggc tttaaactcc aggtctttcc tttttaaaat atttctgcat tctcttttat     4620

gaactagatc aggatgcctt gtttttcctg tgctttcacc cccaaaaggt tttgtgcatg     4680

tgtatgaata cacataatat tagtgaatgt gaacccatgt tctatacgca ctaaacacac     4740

agttaatata taaacgcctg cttcatttgt ttcaacacct tcattatcaa tatgattcat     4800

attgatgaga tatagtgatg cataatgagc caggcagaga gctgaaatga tatcagttaa     4860

tgatgtcaca gtgttagcac cctgcatgga tgtggtcaaa atatcattca agttgtactt     4920

cctagttttt atcatcatac tactatgtca tatgattttc agactaattt aacatgagaa     4980

atgttttggc cctaaaggat ttcacttaac ctagttaccc tatttcagta agtattttgg     5040

aattcaaccc tcgaattatt ttttctcatt tcagcatagt gataggggat gcaatgaggc     5100

ttcattattt tttatgacct gcccctcatt tgctctgatg ttccctaaat tctgtaatca     5160

tatcataact tttgttatga atagagagga atgggctcac tgaaacctga cactagaaat     5220

tggtgggtga tgctcataac tgcaaacact tagcttattg aagtgcctct atttacatgt     5280

tctttagtta taatatgtat ttttctaaca gaaatacacg tctgtaattg gtatatatta     5340

tactttgtat gtgtcacaac aaaagctaaa cagaggctaa agtctttagc agagaagaat     5400

gaattacaaa tttaccaata agagctctgt ttatggttct gtattgaagg acaaccatga     5460

caaccttctg tcattttcac gaaggccaag ttggtacttt gattatagcc atcgtagaac     5520

attagcacta gaaatctgtc tcccttacaa tgacttacct agctagcatc aagtaacttg     5580

tatcacctgc tttaaatgta agggatagaa aatactattt tgtctacact gaaaaacatt     5640

attattcatt gataagtagt aataattata aaagtaacat tctttaaagc aaacacattg     5700

aaaatattat tacaggcaga accctgattt ttaatttata ttccctgctg cagacattag     5760

ccttctttaa ttcttttgcc attacataca tgtttcggct acagactgaa cacgaactaa     5820

agtccctaag gaggaaaaaa ccttaacata ttcctgagat gtgattcttt tattacttct     5880

ttttgcaaag ctaattatca aatgatttga ttaaacctag acgcattagg aaatgcaagt     5940

tttacctaaa acttgcagaa atttaaacac atttccattt acttactaac gaacagacct     6000

gatttttatt taaaaacaca atttagcttt gccaacagaa gagtaaagga aaccataact     6060

tataaatttg taatgtgttc ctccttgttg gagacattag ccagtgttta gttttagacc     6120

aacttataca aagagagtat tgatttgtac acattctgga gacttgctat atcatggttt     6180

gctatggcac agactcagct tagcatgggg acattttgaa cttcattcaa agttgagtag     6240

ttactggaac ctttgacatt gccttgtaat gaggtacttc caaaaaaaga cccctaacaa     6300

tggcataata gtgaggtctc tctgtgcata tacataatat atatgcagga taaatgtgtg     6360

caccaatcaa atctaaaatt ttatgtgact gtcaaatgaa tattatttgg gttaagattt     6420

ttcatttctg atttggatag aaaattgcta ttaatcttgt attaaaatag tttttaaaaa     6480

tctaccagtg ccctttctgc attttcttaa ttattgtcat agtctaaatt tcagagccat     6540

ggaatttttt gtgtttgaga catttttaga agcttcaata ttaaaaaaca acaacaaacc     6600

tcgtatatta aaacagtgcc actctcctaa gtacactcag catctgaaat caggaactat     6660

ttgaacttta gaacatttag agcttcccaa atgtgtatgg aaaatactgt agcgctgttc     6720

ttttgtactg atttcttctc agaggataaa tttagtgact tgaaaactga tgtcaatact     6780

ttataaatga ggtcagaaaa taagatcaaa tgtgaaaaga ctaataattt cccaatttag     6840

ccaattgcat tgatttttat acttctgaaa tgtttccatc ctctcaggca tgctaaatat     6900

tgtataacct gctaaagatt tatttcacaa atgcttattg aactcttatt ctctataaac     6960

cctgctctag gggatttatc actggctgtg aaaaaccacc agttgaaaat tattcattcc     7020

ttaatgcagc taatcataat tattacagat aaataatgta tttcaagaat gatcttataa     7080

ataaaggaac ccatacaaac aaaaaaaaaa aaaa                                 7114


<210>  51
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Pro Ser Trp Ile Gly Ala Val Ile Leu Pro Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Ser Leu Pro Ala Gly Ala Asp Val Lys Ala Arg Ser Cys Gly Glu 
            20                  25                  30          


Val Arg Gln Ala Tyr Gly Ala Lys Gly Phe Ser Leu Ala Asp Ile Pro 
        35                  40                  45              


Tyr Gln Glu Ile Ala Gly Glu His Leu Arg Ile Cys Pro Gln Glu Tyr 
    50                  55                  60                  


Thr Cys Cys Thr Thr Glu Met Glu Asp Lys Leu Ser Gln Gln Ser Lys 
65                  70                  75                  80  


Leu Glu Phe Glu Asn Leu Val Glu Glu Thr Ser His Phe Val Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Arg His Lys Lys Phe Asp Glu Phe Phe Arg Glu Leu 
            100                 105                 110         


Leu Glu Asn Ala Glu Lys Ser Leu Asn Asp Met Phe Val Arg Thr Tyr 
        115                 120                 125             


Gly Met Leu Tyr Met Gln Asn Ser Glu Val Phe Gln Asp Leu Phe Thr 
    130                 135                 140                 


Glu Leu Lys Arg Tyr Tyr Thr Gly Gly Asn Val Asn Leu Glu Glu Met 
145                 150                 155                 160 


Leu Asn Asp Phe Trp Ala Arg Leu Leu Glu Arg Met Phe Gln Leu Ile 
                165                 170                 175     


Asn Pro Gln Tyr His Phe Ser Glu Asp Tyr Leu Glu Cys Val Ser Lys 
            180                 185                 190         


Tyr Thr Asp Gln Leu Lys Pro Phe Gly Asp Val Pro Arg Lys Leu Lys 
        195                 200                 205             


Ile Gln Val Thr Arg Ala Phe Ile Ala Ala Arg Thr Phe Val Gln Gly 
    210                 215                 220                 


Leu Thr Val Gly Arg Glu Val Ala Asn Arg Val Ser Lys Val Ser Pro 
225                 230                 235                 240 


Thr Pro Gly Cys Ile Arg Ala Leu Met Lys Met Leu Tyr Cys Pro Tyr 
                245                 250                 255     


Cys Arg Gly Leu Pro Thr Val Arg Pro Cys Asn Asn Tyr Cys Leu Asn 
            260                 265                 270         


Val Met Lys Gly Cys Leu Ala Asn Gln Ala Asp Leu Asp Thr Glu Trp 
        275                 280                 285             


Asn Leu Phe Ile Asp Ala Met Leu Leu Val Ala Glu Arg Leu Glu Gly 
    290                 295                 300                 


Pro Phe Asn Ile Glu Ser Val Met Asp Pro Ile Asp Val Lys Ile Ser 
305                 310                 315                 320 


Glu Ala Ile Met Asn Met Gln Glu Asn Ser Met Gln Val Ser Ala Lys 
                325                 330                 335     


Val Phe Gln Gly Cys Gly Gln Pro Lys Pro Ala Pro Ala Leu Arg Ser 
            340                 345                 350         


Ala Arg Ser Ala Pro Glu Asn Phe Asn Thr Arg Phe Arg Pro Tyr Asn 
        355                 360                 365             


Pro Glu Glu Arg Pro Thr Thr Ala Ala Gly Thr Ser Leu Asp Arg Leu 
    370                 375                 380                 


Val Thr Asp Ile Lys Glu Lys Leu Lys Leu Ser Lys Lys Val Trp Ser 
385                 390                 395                 400 


Ala Leu Pro Tyr Thr Ile Cys Lys Asp Glu Ser Val Thr Ala Gly Thr 
                405                 410                 415     


Ser Asn Glu Glu Glu Cys Trp Asn Gly His Ser Lys Ala Arg Tyr Leu 
            420                 425                 430         


Pro Glu Ile Met Asn Asp Gly Leu Thr Asn Gln Ile Asn Asn Pro Glu 
        435                 440                 445             


Val Asp Val Asp Ile Thr Arg Pro Asp Thr Phe Ile Arg Gln Gln Ile 
    450                 455                 460                 


Met Ala Leu Arg Val Met Thr Asn Lys Leu Lys Asn Ala Tyr Asn Gly 
465                 470                 475                 480 


Asn Asp Val Asn Phe Gln Asp Thr Ser Asp Glu Ser Ser Gly Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Cys Met Asp Asp Val Cys Pro Thr Glu Phe Glu Phe 
            500                 505                 510         


Val Thr Thr Glu Ala Pro Ala Val Asp Pro Asp Arg Arg Glu Val Asp 
        515                 520                 525             


Ser Ser Ala Ala Gln Arg Gly His Ser Leu Leu Ser Trp Ser Leu Thr 
    530                 535                 540                 


Cys Ile Val Leu Ala Leu Gln Arg Leu Cys Arg 
545                 550                 555 


<210>  52
<211>  2054
<212>  DNA
<213>  Homo sapiens

<400>  52
actgggctct ctaaattcat ttcagctcta ggtaaggtta aactcttctc ccgtcttctg       60

gattttcagg ttctccaggg ccgatgtatg tttggagatg gatttccccc tctcacactt      120

caggcactca gttttttggc agtctcatgg agttttcagt ggcaagccgc ttatttcaaa      180

tgggatttgg aaaggattcc gtgatggtta atattgagtg tcaacttgat tggattgaag      240

gatgcaaagt attgttcctg ggtgtgtctg tgagggtgtc accaaaggag atgaacattt      300

gaatcagtga gctgggagac acaaacccat actcaatctt gggggacacc atctaatcag      360

ctgccagtgc aactaggata aaatcaggca gagaaatttg gaaagactag actggctgag      420

tcttctggcc ttcatctttc tcccatgcta gatgcttcct gacctcgaat atcagactcc      480

aagttcttta gcttttggac tcttggacct ttggccacag acggaaggct gcacttttga      540

agttttggga cttggactgg cttccttgct cctcagctta cagatggcct attgtgggac      600

ttcaccttgt gattgtgatt tcaaaccttc tgggtttctt cccagcgcta aatcctgtcg      660

actggattca ctaggatgaa tagagaaaga agtgttacat tttaagataa tttcttttct      720

aaacacacag aaagttttga aaccaatgga gagatcaaca caagctttgg agaggagatc      780

aaaatatctg cttcactgga aggagttttg gattgctcaa caaggttcag atctgtggca      840

taatcaggct tcctaatcct gaaccaaagt tgttgttgta tctcgtagtt gtcacctgag      900

agctgactga cctgtttcaa gcatatgtga gatgccttct ggaaatgccc ggaagcatat      960

agctaatggg atgaggcatt tcaaggttga acttcagcaa gagcaagtgg gataaagggc     1020

aaaaagcagc acattccttt caaaatgtcc ccattttaaa ctgcaggcta gagtagacaa     1080

tggaaatata tgacatataa agaaactggt gagattatta agcagagggc cttctgggga     1140

gcattaaaga gtgagcaaga aaaatttctc agacatggtg attctagaat tgaaaaatca     1200

tagactcttt ctcttctctc tcctttgaga gtttccagat gaattcttgg atctggctac     1260

tgagcaaata tatgaataat aacctaggat cagctgggta taagaggttt ccaccagaag     1320

tccatgaaaa ccaatgtttt taagcatcta ttgggcaact accataaaca atcagcaaga     1380

tgtttaaaca gttgattctg ccggcggccc aaccagtttt taactgtatc acgaaaactg     1440

gcctgggggt acagtctgag attattccag ccctgctttt acaccgccag aaattccctt     1500

tctgttacaa atttctaccc cagagaggtt tgcatattct tggcattttc actgtgcatc     1560

agtgaatcag ctagcctacg ggccaaggag aggggaaaaa aatcccaaat aaaactcaac     1620

ccagttagga tgtcttcatc tatttttcag tgggaaaaaa tacagctgga ctcagtgact     1680

tcagtcaaaa gcaaacatta ctagttgctt catttttcta atttttattt ttgactctca     1740

agttttggag ggcataataa agacatagcc tcagcaaagt cacttagaag attgagttcg     1800

ttattttgca aagcttgggt agtgacactt ctgcaaaatg cacaagcaca tgagcagaga     1860

gatgtgtgaa ttcaggaaag cagccaaatg cacatcagag ctgaggaatg tcacagcgaa     1920

atgaagaaaa cttgtaaaca cctatctgta tttttaggta gagaatgttc taacatattg     1980

ccaatgggtg ctgcctgtgt gttccttccc ctaagcttta aactcaactg atattaaagg     2040

tgatttgaaa acaa                                                       2054


<210>  53
<211>  1815
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (39)..(1379)

<400>  53
tcattactac agggcaggaa gggcacgttc tcatcagc atg agg gag tgc ctt tcc       56
                                          Met Arg Glu Cys Leu Ser         
                                          1               5               

atc cac atc ggt caa gct ggc atc cag att ggg gac gcc tgc tgg gaa        104
Ile His Ile Gly Gln Ala Gly Ile Gln Ile Gly Asp Ala Cys Trp Glu           
            10                  15                  20                    

ctc tat tgc ctg gaa cat gga atc cag cca aat ggc gtt gtt ctt gac        152
Leu Tyr Cys Leu Glu His Gly Ile Gln Pro Asn Gly Val Val Leu Asp           
        25                  30                  35                        

act caa cag gat cag ctg gaa aat gca aaa atg gag cac aca aat gca        200
Thr Gln Gln Asp Gln Leu Glu Asn Ala Lys Met Glu His Thr Asn Ala           
    40                  45                  50                            

tct ttc gat acc ttc ttc tgt gag aca aga gct ggg aag cat gtg cct        248
Ser Phe Asp Thr Phe Phe Cys Glu Thr Arg Ala Gly Lys His Val Pro           
55                  60                  65                  70            

aga gca ctc ttc gtg gac ttg gag cca act gtt ata gat ggg atc cgg        296
Arg Ala Leu Phe Val Asp Leu Glu Pro Thr Val Ile Asp Gly Ile Arg           
                75                  80                  85                

acg ggc cag cac cgt tca ctc ttc cac ccc gag cag ctc ctt agc gga        344
Thr Gly Gln His Arg Ser Leu Phe His Pro Glu Gln Leu Leu Ser Gly           
            90                  95                  100                   

aag gag gat gct gct aac aat tac gcg cga ggc cgt tac tct gtg ggg        392
Lys Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly Arg Tyr Ser Val Gly           
        105                 110                 115                       

tcg gag gtc atc gac ctt gtg ctg gag agg acc cgg aag ctg gca gaa        440
Ser Glu Val Ile Asp Leu Val Leu Glu Arg Thr Arg Lys Leu Ala Glu           
    120                 125                 130                           

cag tgt ggt gga ctt cag gga ttt ttg att ttc cga agc ttt gga gga        488
Gln Cys Gly Gly Leu Gln Gly Phe Leu Ile Phe Arg Ser Phe Gly Gly           
135                 140                 145                 150           

ggc act ggt tca ggg ttt acg tct ctc tta atg gag agg ctc aca gga        536
Gly Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Thr Gly           
                155                 160                 165               

gaa tat agc aga aag act aag ctg gag ttc tcg gtc tac cca gcc ccc        584
Glu Tyr Ser Arg Lys Thr Lys Leu Glu Phe Ser Val Tyr Pro Ala Pro           
            170                 175                 180                   

agg atc tcc act gct gtg gta gag cct tat aac tct gtc ctc acc acc        632
Arg Ile Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Val Leu Thr Thr           
        185                 190                 195                       

cac tcc acc aca gag cac acg gac tgt acc ttc atg gtg gac aac gag        680
His Ser Thr Thr Glu His Thr Asp Cys Thr Phe Met Val Asp Asn Glu           
    200                 205                 210                           

gcc gtc tat gat ata tgc cat cgt aaa ctc ggt gtt gaa tgc ccc tct        728
Ala Val Tyr Asp Ile Cys His Arg Lys Leu Gly Val Glu Cys Pro Ser           
215                 220                 225                 230           

cat gcc agc atc aat aga ttg gtg gtt cag gtg gta tct tcc atc act        776
His Ala Ser Ile Asn Arg Leu Val Val Gln Val Val Ser Ser Ile Thr           
                235                 240                 245               

gcc tcc ctc cgg ttt gaa ggg ccc ttg aat gta gac cta att gaa ttc        824
Ala Ser Leu Arg Phe Glu Gly Pro Leu Asn Val Asp Leu Ile Glu Phe           
            250                 255                 260                   

cag acc aac ctg gta cct tat ccg aga ata cat ttc ccc atg aca gcc        872
Gln Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Met Thr Ala           
        265                 270                 275                       

ttc gcc ccc atc gtc tct gct gac aaa gcc tac cat gag cag ttc tct        920
Phe Ala Pro Ile Val Ser Ala Asp Lys Ala Tyr His Glu Gln Phe Ser           
    280                 285                 290                           

gtg tca gac atc acc act gcc tgc ttt gag tcc tcc aac cag ctg gtc        968
Val Ser Asp Ile Thr Thr Ala Cys Phe Glu Ser Ser Asn Gln Leu Val           
295                 300                 305                 310           

aag tgt gat cct cgg ctt ggg aag tac atg gcc tgc tgc cta ctc tat       1016
Lys Cys Asp Pro Arg Leu Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr           
                315                 320                 325               

aga ggg gat gtg gtc ccc aag gaa gtg aat gca gca atc gca gcc acg       1064
Arg Gly Asp Val Val Pro Lys Glu Val Asn Ala Ala Ile Ala Ala Thr           
            330                 335                 340                   

aag tcg agg cac tct gtt cag ttt gta gat tgg tgt cca act ggt ttc       1112
Lys Ser Arg His Ser Val Gln Phe Val Asp Trp Cys Pro Thr Gly Phe           
        345                 350                 355                       

aag gtg ggc atc aac aat cgg ccg ccc acg gtg atg ccg ggt ggg gac       1160
Lys Val Gly Ile Asn Asn Arg Pro Pro Thr Val Met Pro Gly Gly Asp           
    360                 365                 370                           

ctg gcc aaa gtc cac cgg tcc atc tgc atg ctg agc aac acc acg gcg       1208
Leu Ala Lys Val His Arg Ser Ile Cys Met Leu Ser Asn Thr Thr Ala           
375                 380                 385                 390           

att gtg gag gcc tgg gcc cgc ctg gac cac aag ttt gac ctc atg tac       1256
Ile Val Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr           
                395                 400                 405               

gcc aag aga gca ttt ctg cac tgg tac ctc aga gaa ggc atg gaa gaa       1304
Ala Lys Arg Ala Phe Leu His Trp Tyr Leu Arg Glu Gly Met Glu Glu           
            410                 415                 420                   

gca gag ttc ttg gag gcc agg gaa gat ctg gca gcc ctg gag agg gac       1352
Ala Glu Phe Leu Glu Ala Arg Glu Asp Leu Ala Ala Leu Glu Arg Asp           
        425                 430                 435                       

tat gag gaa gtg gcg caa agt ttc tga ggcatgtatg atgggtgcaa             1399
Tyr Glu Glu Val Ala Gln Ser Phe                                           
    440                 445                                               

atgaatgtca agttaaaatg gcatgttttc ttttcaagcc gttatatgcc tagtgggtag     1459

ttcccctgat gagcagaaaa atgaactcaa atcaggcaag actctaggtt ccacactaaa     1519

ttaagtgggt cagtaccaac aatgaacaca ttatttcctg gtctactggt acaagtcagc     1579

tctgctacct gggagccttt ggaagcttag agtcctttga actgctgagt cacttctagg     1639

tgggattttt ttgttttacc aagagacaat gaaatcctga agtttatgct tttcctttct     1699

ggtaccggaa gtagaaaaca gcacatgttg attacgaatg ttttttcccc catgtctaca     1759

ttttttacac tgattaaatc ataaatattt tcagtatgaa aaaaaaaaaa aaaaaa         1815


<210>  54
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Arg Glu Cys Leu Ser Ile His Ile Gly Gln Ala Gly Ile Gln Ile 
1               5                   10                  15      


Gly Asp Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asn Gly Val Val Leu Asp Thr Gln Gln Asp Gln Leu Glu Asn Ala Lys 
        35                  40                  45              


Met Glu His Thr Asn Ala Ser Phe Asp Thr Phe Phe Cys Glu Thr Arg 
    50                  55                  60                  


Ala Gly Lys His Val Pro Arg Ala Leu Phe Val Asp Leu Glu Pro Thr 
65                  70                  75                  80  


Val Ile Asp Gly Ile Arg Thr Gly Gln His Arg Ser Leu Phe His Pro 
                85                  90                  95      


Glu Gln Leu Leu Ser Gly Lys Glu Asp Ala Ala Asn Asn Tyr Ala Arg 
            100                 105                 110         


Gly Arg Tyr Ser Val Gly Ser Glu Val Ile Asp Leu Val Leu Glu Arg 
        115                 120                 125             


Thr Arg Lys Leu Ala Glu Gln Cys Gly Gly Leu Gln Gly Phe Leu Ile 
    130                 135                 140                 


Phe Arg Ser Phe Gly Gly Gly Thr Gly Ser Gly Phe Thr Ser Leu Leu 
145                 150                 155                 160 


Met Glu Arg Leu Thr Gly Glu Tyr Ser Arg Lys Thr Lys Leu Glu Phe 
                165                 170                 175     


Ser Val Tyr Pro Ala Pro Arg Ile Ser Thr Ala Val Val Glu Pro Tyr 
            180                 185                 190         


Asn Ser Val Leu Thr Thr His Ser Thr Thr Glu His Thr Asp Cys Thr 
        195                 200                 205             


Phe Met Val Asp Asn Glu Ala Val Tyr Asp Ile Cys His Arg Lys Leu 
    210                 215                 220                 


Gly Val Glu Cys Pro Ser His Ala Ser Ile Asn Arg Leu Val Val Gln 
225                 230                 235                 240 


Val Val Ser Ser Ile Thr Ala Ser Leu Arg Phe Glu Gly Pro Leu Asn 
                245                 250                 255     


Val Asp Leu Ile Glu Phe Gln Thr Asn Leu Val Pro Tyr Pro Arg Ile 
            260                 265                 270         


His Phe Pro Met Thr Ala Phe Ala Pro Ile Val Ser Ala Asp Lys Ala 
        275                 280                 285             


Tyr His Glu Gln Phe Ser Val Ser Asp Ile Thr Thr Ala Cys Phe Glu 
    290                 295                 300                 


Ser Ser Asn Gln Leu Val Lys Cys Asp Pro Arg Leu Gly Lys Tyr Met 
305                 310                 315                 320 


Ala Cys Cys Leu Leu Tyr Arg Gly Asp Val Val Pro Lys Glu Val Asn 
                325                 330                 335     


Ala Ala Ile Ala Ala Thr Lys Ser Arg His Ser Val Gln Phe Val Asp 
            340                 345                 350         


Trp Cys Pro Thr Gly Phe Lys Val Gly Ile Asn Asn Arg Pro Pro Thr 
        355                 360                 365             


Val Met Pro Gly Gly Asp Leu Ala Lys Val His Arg Ser Ile Cys Met 
    370                 375                 380                 


Leu Ser Asn Thr Thr Ala Ile Val Glu Ala Trp Ala Arg Leu Asp His 
385                 390                 395                 400 


Lys Phe Asp Leu Met Tyr Ala Lys Arg Ala Phe Leu His Trp Tyr Leu 
                405                 410                 415     


Arg Glu Gly Met Glu Glu Ala Glu Phe Leu Glu Ala Arg Glu Asp Leu 
            420                 425                 430         


Ala Ala Leu Glu Arg Asp Tyr Glu Glu Val Ala Gln Ser Phe 
        435                 440                 445     


<210>  55
<211>  3890
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (49)..(2403)

<400>  55
gcacctgggc acctgggcag ccgccgcggc gctggctaga cgtgcgcg atg gag ggc        57
                                                     Met Glu Gly          
                                                     1                    

gac ggc ggg acc cca tgg gcc ctg gcg ctg ctg cgc acc ttc gac gcg        105
Asp Gly Gly Thr Pro Trp Ala Leu Ala Leu Leu Arg Thr Phe Asp Ala           
    5                   10                  15                            

ggc gag ttc acg ggc tgg gag aag gtg ggc tcg ggc ggc ttc ggg cag        153
Gly Glu Phe Thr Gly Trp Glu Lys Val Gly Ser Gly Gly Phe Gly Gln           
20                  25                  30                  35            

gtg tac aag gtg cgc cat gtc cac tgg aag acc tgg ctg gcc atc aag        201
Val Tyr Lys Val Arg His Val His Trp Lys Thr Trp Leu Ala Ile Lys           
                40                  45                  50                

tgc tcg ccc agc ctg cac gtc gac gac agg gag cgc atg gag ctt ttg        249
Cys Ser Pro Ser Leu His Val Asp Asp Arg Glu Arg Met Glu Leu Leu           
            55                  60                  65                    

gaa gaa gcc aag aag atg gag atg gcc aag ttt cgc tac atc ctg cct        297
Glu Glu Ala Lys Lys Met Glu Met Ala Lys Phe Arg Tyr Ile Leu Pro           
        70                  75                  80                        

gtg tat ggc atc tgc cgc gaa cct gtc ggc ctg gtc atg gag tac atg        345
Val Tyr Gly Ile Cys Arg Glu Pro Val Gly Leu Val Met Glu Tyr Met           
    85                  90                  95                            

gag acg ggc tcc ctg gaa aag ctg ctg gct tcg gag cca ttg cca tgg        393
Glu Thr Gly Ser Leu Glu Lys Leu Leu Ala Ser Glu Pro Leu Pro Trp           
100                 105                 110                 115           

gat ctc cgg ttc cga atc atc cac gag acg gcg gtg ggc atg aac ttc        441
Asp Leu Arg Phe Arg Ile Ile His Glu Thr Ala Val Gly Met Asn Phe           
                120                 125                 130               

ctg cac tgc atg gcc ccg cca ctc ctg cac ctg gac ctc aag ccc gcg        489
Leu His Cys Met Ala Pro Pro Leu Leu His Leu Asp Leu Lys Pro Ala           
            135                 140                 145                   

aac atc ctg ctg gat gcc cac tac cac gtc aag att tct gat ttt ggt        537
Asn Ile Leu Leu Asp Ala His Tyr His Val Lys Ile Ser Asp Phe Gly           
        150                 155                 160                       

ctg gcc aag tgc aac ggg ctg tcc cac tcg cat gac ctc agc atg gat        585
Leu Ala Lys Cys Asn Gly Leu Ser His Ser His Asp Leu Ser Met Asp           
    165                 170                 175                           

ggc ctg ttt ggc aca atc gcc tac ctc cct cca gag cgc atc agg gag        633
Gly Leu Phe Gly Thr Ile Ala Tyr Leu Pro Pro Glu Arg Ile Arg Glu           
180                 185                 190                 195           

aag agc cgg ctc ttc gac acc aag cac gat gta tac agc ttt gcg atc        681
Lys Ser Arg Leu Phe Asp Thr Lys His Asp Val Tyr Ser Phe Ala Ile           
                200                 205                 210               

gtc atc tgg ggc gtg ctc aca cag aag aag ccg ttt gca gat gag aag        729
Val Ile Trp Gly Val Leu Thr Gln Lys Lys Pro Phe Ala Asp Glu Lys           
            215                 220                 225                   

aac atc ctg cac atc atg gtg aag gtg gtg aag ggc cac cgc ccc gag        777
Asn Ile Leu His Ile Met Val Lys Val Val Lys Gly His Arg Pro Glu           
        230                 235                 240                       

ctg ccg ccc gtg tgc aga gcc cgg ccg cgc gcc tgc agc cac ctg ata        825
Leu Pro Pro Val Cys Arg Ala Arg Pro Arg Ala Cys Ser His Leu Ile           
    245                 250                 255                           

cgc ctc atg cag cgg tgc tgg cag ggg gat ccg cga gtt agg ccc acc        873
Arg Leu Met Gln Arg Cys Trp Gln Gly Asp Pro Arg Val Arg Pro Thr           
260                 265                 270                 275           

ttc caa gaa att act tct gaa acc gag gac ctg tgt gaa aag cct gat        921
Phe Gln Glu Ile Thr Ser Glu Thr Glu Asp Leu Cys Glu Lys Pro Asp           
                280                 285                 290               

gac gaa gtg aaa gaa act gct cat gat ctg gac gtg aaa agc ccc ccg        969
Asp Glu Val Lys Glu Thr Ala His Asp Leu Asp Val Lys Ser Pro Pro           
            295                 300                 305                   

gag ccc agg agc gag gtg gtg cct gcg agg ctc aag cgg gcc tct gcc       1017
Glu Pro Arg Ser Glu Val Val Pro Ala Arg Leu Lys Arg Ala Ser Ala           
        310                 315                 320                       

ccc acc ttc gat aac gac tac agc ctc tcc gag ctg ctc tca cag ctg       1065
Pro Thr Phe Asp Asn Asp Tyr Ser Leu Ser Glu Leu Leu Ser Gln Leu           
    325                 330                 335                           

gac tct gga gtt tcc cag gct gtc gag ggc ccc gag gag ctc agc cgc       1113
Asp Ser Gly Val Ser Gln Ala Val Glu Gly Pro Glu Glu Leu Ser Arg           
340                 345                 350                 355           

agc tcc tct gag tcc aag ctg cca tcg tcc ggc agt ggg aag agg ctc       1161
Ser Ser Ser Glu Ser Lys Leu Pro Ser Ser Gly Ser Gly Lys Arg Leu           
                360                 365                 370               

tcg ggg gtg tcc tcg gtg gac tcc gcc ttc tct tcc aga gga tca ctg       1209
Ser Gly Val Ser Ser Val Asp Ser Ala Phe Ser Ser Arg Gly Ser Leu           
            375                 380                 385                   

tcg ctg tcc ttt gag cgg gaa cct tca acc agc gat ctg ggc acc aca       1257
Ser Leu Ser Phe Glu Arg Glu Pro Ser Thr Ser Asp Leu Gly Thr Thr           
        390                 395                 400                       

gac gtc cag aag aag aag ctt gtg gat gcc atc gtg tcc ggg gac acc       1305
Asp Val Gln Lys Lys Lys Leu Val Asp Ala Ile Val Ser Gly Asp Thr           
    405                 410                 415                           

agc aaa ctg atg aag atc ctg cag ccg cag gac gtg gac ctg gca ctg       1353
Ser Lys Leu Met Lys Ile Leu Gln Pro Gln Asp Val Asp Leu Ala Leu           
420                 425                 430                 435           

gac agc ggt gcc agc ctg ctg cac ctg gcg gtg gag gcc ggg caa gag       1401
Asp Ser Gly Ala Ser Leu Leu His Leu Ala Val Glu Ala Gly Gln Glu           
                440                 445                 450               

gag tgc gcc aag tgg ctg ctg ctc aac aat gcc aac ccc aac ctg agc       1449
Glu Cys Ala Lys Trp Leu Leu Leu Asn Asn Ala Asn Pro Asn Leu Ser           
            455                 460                 465                   

aac cgt agg ggc tcc acc ccg ttg cac atg gcc gtg gag agg agg gtg       1497
Asn Arg Arg Gly Ser Thr Pro Leu His Met Ala Val Glu Arg Arg Val           
        470                 475                 480                       

cgg ggt gtc gtg gag ctc ctg ctg gcg cgg aag atc agt gtc aac gcc       1545
Arg Gly Val Val Glu Leu Leu Leu Ala Arg Lys Ile Ser Val Asn Ala           
    485                 490                 495                           

aag gat gag gac cag tgg aca gcc ctc cac ttt gca gcc cag aac ggg       1593
Lys Asp Glu Asp Gln Trp Thr Ala Leu His Phe Ala Ala Gln Asn Gly           
500                 505                 510                 515           

gac gag tct agc aca cgg ctg ctg ttg gag aag aac gcc tcg gtc aac       1641
Asp Glu Ser Ser Thr Arg Leu Leu Leu Glu Lys Asn Ala Ser Val Asn           
                520                 525                 530               

gag gtg gac ttt gag ggc cgg acg ccc atg cac gtg gcc tgc cag cac       1689
Glu Val Asp Phe Glu Gly Arg Thr Pro Met His Val Ala Cys Gln His           
            535                 540                 545                   

ggg cag gag aat atc gtg cgc atc ctg ctg cgc cga ggc gtg gac gtg       1737
Gly Gln Glu Asn Ile Val Arg Ile Leu Leu Arg Arg Gly Val Asp Val           
        550                 555                 560                       

agc ctg cag ggc aag gat gcc tgg ctg cca ctg cac tac gct gcc tgg       1785
Ser Leu Gln Gly Lys Asp Ala Trp Leu Pro Leu His Tyr Ala Ala Trp           
    565                 570                 575                           

cag ggc cac ctg ccc atc gtc aag ctg ctg gcc aag cag ccg ggg gtg       1833
Gln Gly His Leu Pro Ile Val Lys Leu Leu Ala Lys Gln Pro Gly Val           
580                 585                 590                 595           

agt gtg aac gcc cag acg ctg gat ggg agg acg cca ttg cac ctg gcc       1881
Ser Val Asn Ala Gln Thr Leu Asp Gly Arg Thr Pro Leu His Leu Ala           
                600                 605                 610               

gca cag cgc ggg cac tac cgc gtg gcc cgc atc ctc atc gac ctg tgc       1929
Ala Gln Arg Gly His Tyr Arg Val Ala Arg Ile Leu Ile Asp Leu Cys           
            615                 620                 625                   

tcc gac gtc aac gtc tgc agc ctg ctg gca cag aca ccc ctg cac gtg       1977
Ser Asp Val Asn Val Cys Ser Leu Leu Ala Gln Thr Pro Leu His Val           
        630                 635                 640                       

gcc gcg gag acg ggg cac acg agc act gcc agg ctg ctc ctg cat cgg       2025
Ala Ala Glu Thr Gly His Thr Ser Thr Ala Arg Leu Leu Leu His Arg           
    645                 650                 655                           

ggc gct ggc aag gag gcc atg acc tca gac ggc tac acc gct ctg cac       2073
Gly Ala Gly Lys Glu Ala Met Thr Ser Asp Gly Tyr Thr Ala Leu His           
660                 665                 670                 675           

ctg gct gcc cgc aac gga cac ctg gcc act gtc aag ctg ctt gtc gag       2121
Leu Ala Ala Arg Asn Gly His Leu Ala Thr Val Lys Leu Leu Val Glu           
                680                 685                 690               

gag aag gcc gat gtg ctg gcc cgg gga ccc ctg aac cag acg gcg ctg       2169
Glu Lys Ala Asp Val Leu Ala Arg Gly Pro Leu Asn Gln Thr Ala Leu           
            695                 700                 705                   

cac ctg gct gcc gcc cac ggg cac tcg gag gtg gtg gag gag ttg gtc       2217
His Leu Ala Ala Ala His Gly His Ser Glu Val Val Glu Glu Leu Val           
        710                 715                 720                       

agc gcc gat gtc att gac ctg ttc gac gag cag ggg ctc agc gcg ctg       2265
Ser Ala Asp Val Ile Asp Leu Phe Asp Glu Gln Gly Leu Ser Ala Leu           
    725                 730                 735                           

cac ctg gcc gcc cag ggc cgg cac gca cag acg gtg gag act ctg ctc       2313
His Leu Ala Ala Gln Gly Arg His Ala Gln Thr Val Glu Thr Leu Leu           
740                 745                 750                 755           

agg cat ggg gcc cac atc aac ctg cag agc ctc aag ttc cag ggc ggc       2361
Arg His Gly Ala His Ile Asn Leu Gln Ser Leu Lys Phe Gln Gly Gly           
                760                 765                 770               

cat ggc ccc gcc gcc acg ctc ctg cgg cga agc aag acc tag               2403
His Gly Pro Ala Ala Thr Leu Leu Arg Arg Ser Lys Thr                       
            775                 780                                       

ctggctgcct gcggagaccg ggggtccacg tggggctctt gtcctgtcct gtgttcctcg     2463

tggggatgga acgatcctgc gtggggccct gttgtggctt acctaaatgt taaccaagca     2523

gaggtgacat ggtgccatca ggaggcggct gctgctgacc ggagtgtccc ctccaggtga     2583

agctggctca ggtgcacatg cccgctccat catcgatcta ggcacctgct gtctgaaggg     2643

accgtgggtc agaatcattt cgttgtgctc ctaatgggtc gctgaggctg gtctctcagt     2703

gatgaagccc caggcgtgga agcatccact ctctcctgag gcgagccacc ttgggttgct     2763

ggagctcacc agtcttgagg gaggtgcagg ggaaactgtg ttttttatct tcatacatga     2823

cggtgggcag agaggcctgt cttaaagttt ccatggaatt gttttataaa atatcttaag     2883

agatgaatac cttatcagct gttgcttgaa acctgttaaa aatgttcata acattggata     2943

gtctagtctc taaatgatga ctaagtagtg gggttggctt tgaaaacaat gttttatgca     3003

acaaggaacg aatggtagca gccagctttg cggggcgtat gtgtggccag ctcttaacca     3063

ttccagtcta ttacttgggt gagtccttgt ggacaaccac acacacgtgc ccacatggta     3123

ctagctgccg ttcgtttctc gttgcctaag atgttttggc aactctagag ccacaggcct     3183

aagtcattaa aaaattctcc ctttgtaacc tcagtgctgg ggactgaggc gagccccctc     3243

aggtcgctgg agtgcaccag tcttggggaa gaggtgcagg agaagctgtg ttttttatct     3303

ccacacgcag tatgaagata aaattacata gtattaccta gacatagaca gtattaccta     3363

ggtagatgca ctgctcacct gcgcccttcc cagctctcat ttttgttagg tgatttggga     3423

tagggatagt gttttggggt atggggggag tgtttctgac ctgctttgca gacgtgcctc     3483

cgcacctcag cagtttgggg tgtggcccca gggcggttct tggatgtaaa agatgtggcc     3543

atctagcctc gtaacttcac tgtcacctgt gtcccatagg gtgccttctg aatactgtta     3603

ttagaataag tttgttgcag aacgtgaccc tgcgtgcaaa catgtaccgt ggcctggtat     3663

atgatagaga ttgatattaa tgtaccatgt atgttaatgt gaatctgtgg gcaggatact     3723

tttccatggc aggaaatatc caagctgttg aaactggcta tgttttaata tgcctcattg     3783

tgcctttact gttgtgtgga ctgcgtgagg gacaagaagt tccatttgat gtcaataaag     3843

caaagtactt gcctactttt ttgaagctga aaaaaaaaaa aaaaaaa                   3890


<210>  56
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Glu Gly Asp Gly Gly Thr Pro Trp Ala Leu Ala Leu Leu Arg Thr 
1               5                   10                  15      


Phe Asp Ala Gly Glu Phe Thr Gly Trp Glu Lys Val Gly Ser Gly Gly 
            20                  25                  30          


Phe Gly Gln Val Tyr Lys Val Arg His Val His Trp Lys Thr Trp Leu 
        35                  40                  45              


Ala Ile Lys Cys Ser Pro Ser Leu His Val Asp Asp Arg Glu Arg Met 
    50                  55                  60                  


Glu Leu Leu Glu Glu Ala Lys Lys Met Glu Met Ala Lys Phe Arg Tyr 
65                  70                  75                  80  


Ile Leu Pro Val Tyr Gly Ile Cys Arg Glu Pro Val Gly Leu Val Met 
                85                  90                  95      


Glu Tyr Met Glu Thr Gly Ser Leu Glu Lys Leu Leu Ala Ser Glu Pro 
            100                 105                 110         


Leu Pro Trp Asp Leu Arg Phe Arg Ile Ile His Glu Thr Ala Val Gly 
        115                 120                 125             


Met Asn Phe Leu His Cys Met Ala Pro Pro Leu Leu His Leu Asp Leu 
    130                 135                 140                 


Lys Pro Ala Asn Ile Leu Leu Asp Ala His Tyr His Val Lys Ile Ser 
145                 150                 155                 160 


Asp Phe Gly Leu Ala Lys Cys Asn Gly Leu Ser His Ser His Asp Leu 
                165                 170                 175     


Ser Met Asp Gly Leu Phe Gly Thr Ile Ala Tyr Leu Pro Pro Glu Arg 
            180                 185                 190         


Ile Arg Glu Lys Ser Arg Leu Phe Asp Thr Lys His Asp Val Tyr Ser 
        195                 200                 205             


Phe Ala Ile Val Ile Trp Gly Val Leu Thr Gln Lys Lys Pro Phe Ala 
    210                 215                 220                 


Asp Glu Lys Asn Ile Leu His Ile Met Val Lys Val Val Lys Gly His 
225                 230                 235                 240 


Arg Pro Glu Leu Pro Pro Val Cys Arg Ala Arg Pro Arg Ala Cys Ser 
                245                 250                 255     


His Leu Ile Arg Leu Met Gln Arg Cys Trp Gln Gly Asp Pro Arg Val 
            260                 265                 270         


Arg Pro Thr Phe Gln Glu Ile Thr Ser Glu Thr Glu Asp Leu Cys Glu 
        275                 280                 285             


Lys Pro Asp Asp Glu Val Lys Glu Thr Ala His Asp Leu Asp Val Lys 
    290                 295                 300                 


Ser Pro Pro Glu Pro Arg Ser Glu Val Val Pro Ala Arg Leu Lys Arg 
305                 310                 315                 320 


Ala Ser Ala Pro Thr Phe Asp Asn Asp Tyr Ser Leu Ser Glu Leu Leu 
                325                 330                 335     


Ser Gln Leu Asp Ser Gly Val Ser Gln Ala Val Glu Gly Pro Glu Glu 
            340                 345                 350         


Leu Ser Arg Ser Ser Ser Glu Ser Lys Leu Pro Ser Ser Gly Ser Gly 
        355                 360                 365             


Lys Arg Leu Ser Gly Val Ser Ser Val Asp Ser Ala Phe Ser Ser Arg 
    370                 375                 380                 


Gly Ser Leu Ser Leu Ser Phe Glu Arg Glu Pro Ser Thr Ser Asp Leu 
385                 390                 395                 400 


Gly Thr Thr Asp Val Gln Lys Lys Lys Leu Val Asp Ala Ile Val Ser 
                405                 410                 415     


Gly Asp Thr Ser Lys Leu Met Lys Ile Leu Gln Pro Gln Asp Val Asp 
            420                 425                 430         


Leu Ala Leu Asp Ser Gly Ala Ser Leu Leu His Leu Ala Val Glu Ala 
        435                 440                 445             


Gly Gln Glu Glu Cys Ala Lys Trp Leu Leu Leu Asn Asn Ala Asn Pro 
    450                 455                 460                 


Asn Leu Ser Asn Arg Arg Gly Ser Thr Pro Leu His Met Ala Val Glu 
465                 470                 475                 480 


Arg Arg Val Arg Gly Val Val Glu Leu Leu Leu Ala Arg Lys Ile Ser 
                485                 490                 495     


Val Asn Ala Lys Asp Glu Asp Gln Trp Thr Ala Leu His Phe Ala Ala 
            500                 505                 510         


Gln Asn Gly Asp Glu Ser Ser Thr Arg Leu Leu Leu Glu Lys Asn Ala 
        515                 520                 525             


Ser Val Asn Glu Val Asp Phe Glu Gly Arg Thr Pro Met His Val Ala 
    530                 535                 540                 


Cys Gln His Gly Gln Glu Asn Ile Val Arg Ile Leu Leu Arg Arg Gly 
545                 550                 555                 560 


Val Asp Val Ser Leu Gln Gly Lys Asp Ala Trp Leu Pro Leu His Tyr 
                565                 570                 575     


Ala Ala Trp Gln Gly His Leu Pro Ile Val Lys Leu Leu Ala Lys Gln 
            580                 585                 590         


Pro Gly Val Ser Val Asn Ala Gln Thr Leu Asp Gly Arg Thr Pro Leu 
        595                 600                 605             


His Leu Ala Ala Gln Arg Gly His Tyr Arg Val Ala Arg Ile Leu Ile 
    610                 615                 620                 


Asp Leu Cys Ser Asp Val Asn Val Cys Ser Leu Leu Ala Gln Thr Pro 
625                 630                 635                 640 


Leu His Val Ala Ala Glu Thr Gly His Thr Ser Thr Ala Arg Leu Leu 
                645                 650                 655     


Leu His Arg Gly Ala Gly Lys Glu Ala Met Thr Ser Asp Gly Tyr Thr 
            660                 665                 670         


Ala Leu His Leu Ala Ala Arg Asn Gly His Leu Ala Thr Val Lys Leu 
        675                 680                 685             


Leu Val Glu Glu Lys Ala Asp Val Leu Ala Arg Gly Pro Leu Asn Gln 
    690                 695                 700                 


Thr Ala Leu His Leu Ala Ala Ala His Gly His Ser Glu Val Val Glu 
705                 710                 715                 720 


Glu Leu Val Ser Ala Asp Val Ile Asp Leu Phe Asp Glu Gln Gly Leu 
                725                 730                 735     


Ser Ala Leu His Leu Ala Ala Gln Gly Arg His Ala Gln Thr Val Glu 
            740                 745                 750         


Thr Leu Leu Arg His Gly Ala His Ile Asn Leu Gln Ser Leu Lys Phe 
        755                 760                 765             


Gln Gly Gly His Gly Pro Ala Ala Thr Leu Leu Arg Arg Ser Lys Thr 
    770                 775                 780                 


