                         SEQUENCE LISTING

<110>  The Board of Trustees of the University of Illinois
       van der Donk, Wilfred A.
       Okesli, Ayse
       Yang, Xiao
       Walker, Mark
 
<120>  Biosynthesis and Engineering of Lanthipeptides

<130>  UIU01-018-PCT

<150>  US 62/056216
<151>  2014-09-26

<160>  107   

<170>  PatentIn version 3.5

<210>  1
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC NisA PEPTIDE SEQUENCE

<400>  1

Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Lys Thr Ala Thr Cys His Cys Ser Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210>  2
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC NisA PEPTIDFE SEQUENCE PROCESSED BY NisB


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is dehydrobutyrine (Dhb).

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is dehydroalanine (Dha).

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is dehydroalanine (Dha).

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is dehydrobutyrine (Dhb).

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is dehydrobutyrine (Dhb).

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is dehydrobutyrine (Dhb).

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is dehydrobutyrine (Dhb).

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is dehydroalanine (Dha).

<400>  2

Ile Xaa Xaa Ile Xaa Leu Cys Xaa Pro Gly Cys Lys Xaa Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Lys Xaa Ala Xaa Cys His Cys Ser Ile His Val 
            20                  25                  30          


Xaa Lys 
        


<210>  3
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC NisA PEPTIDFE SEQUENCE PROCESSED BY NisC.


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is dehydrobutyrine (Dhb).

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is dehydroalanine (Dha).

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is dehydroalanine (Dha).

<400>  3

Ile Xaa Ala Ile Xaa Leu Ala Xaa Pro Gly Ala Lys Xaa Gly Ala Leu 
1               5                   10                  15      


Met Gly Ala Asn Met Lys Xaa Ala Xaa Ala His Ala Ser Ile His Val 
            20                  25                  30          


Xaa Lys 
        


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nisin Polypeptide containing sulfide bonds between residus 3 and 
       7; between residues 8 and 11; between residues 13 and 19; between
       residues 23 and 26; and between residues 25 and 28.


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is dehydrobutyrine (Dhb).

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is dehydroalanine (Dha).

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is Abu.

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is dehydroalanine (Dha)

<400>  4

Ile Xaa Ala Ile Xaa Leu Ala Xaa Pro Gly Ala Lys Xaa Gly Ala Leu 
1               5                   10                  15      


Met Gly Ala Asn Met Lys Xaa Ala Xaa Ala His Ala Ser Ile His Val 
            20                  25                  30          


Xaa Lys 
        


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC POLYPEPTIDE SEQUENCE


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Ala Ala Cys Xaa Xaa Xaa Xaa Met Pro Pro Ser Xaa Xaa 
1               5                   10              


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC POLYPEPTIDE SEQUENCE


<220>
<221>  misc_feature
<222>  (2)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is dehydroalanine (Dha).

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is dehydroalanine (Dha).

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Cys Xaa Xaa Xaa Xaa Xaa Xaa Met Pro Pro Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Cys 
    


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PROCHLOROSIN 1.1 POLYPEPTIDE


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is Abu.

<400>  7

Phe Phe Ala Val Gln Gly Xaa Ala Asn Arg Phe Xaa Ile Asn Val Ala 
1               5                   10                  15      


<210>  8
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PROCHLOROSIN 2.8 POLYPEPTIDE SEQUENCE

<400>  8

Ala Ala Ala His Gln His Ala Pro Ala Met Pro Pro Ala Tyr Trp Glu 
1               5                   10                  15      


Gly Glu Ala 
            


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.8 SYNTHETIC CORE REGION POLYPEPTIDE SEQUENCE


<220>
<221>  misc_feature
<222>  (2)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Cys Xaa Xaa Xaa Xaa Xaa Ser Met Pro Pro Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Cys 
    


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-1 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  10

Ala Ala Cys Phe Asn Val His Ile Ser Met Pro Pro Ser His Asn Asn 
1               5                   10                  15      


Val His Cys 
            


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-2 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  11

Ala Ala Cys Asp Val Asn Leu His Ser Met Pro Pro Ser Leu Asp Phe 
1               5                   10                  15      


Phe Val Cys 
            


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-3 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  12

Ala Ala Cys Val Phe His Phe Asp Ser Met Pro Pro Ser Tyr Leu Asp 
1               5                   10                  15      


Asp Asp Cys 
            


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-4 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  13

Ala Ala Cys Asn Ile Asp Phe Leu Ser Met Pro Pro Ser Ile His His 
1               5                   10                  15      


Ile Leu Cys 
            


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-5 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  14

Ala Ala Cys Asn Ile Tyr Tyr Ile Ser Met Pro Pro Ser His His Phe 
1               5                   10                  15      


Val Tyr Cys 
            


<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-6 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  15

Ala Ala Cys His Asp Asn Asn Asn Ser Met Pro Pro Ser Phe Tyr His 
1               5                   10                  15      


Ile Phe Cys 
            


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-7 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  16

Ala Ala Cys His Leu Asn Tyr Asn Ser Met Pro Pro Ser Phe His Ile 
1               5                   10                  15      


Leu Phe Cys 
            


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-8 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  17

Ala Ala Cys Leu Asn Asn Leu Val Ser Met Pro Pro Ser Asn Ile Val 
1               5                   10                  15      


Val Tyr Cys 
            


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-9 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  18

Ala Ala Cys Asn Ile His Ile Tyr Ser Met Pro Pro Ser Asn Asn His 
1               5                   10                  15      


Phe Asn Cys 
            


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-10 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  19

Ala Ala Cys His Asp Ile Asn Leu Ser Met Pro Pro Ser Phe Leu Asn 
1               5                   10                  15      


Val Ile Cys 
            


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-11 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  20

Ala Ala Cys Ile Leu Tyr Leu Ile Ser Met Pro Pro Ser Asn Ile Phe 
1               5                   10                  15      


Asn Asp Cys 
            


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-12 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  21

Ala Ala Cys Phe Phe Asp Ile Asn Ser Met Pro Pro Ser Asp Asp Leu 
1               5                   10                  15      


Tyr Leu Cys 
            


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-13 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  22

Ala Ala Cys Leu Ile Val Asp Tyr Ser Met Pro Pro Ser Ile Asp Asn 
1               5                   10                  15      


His Leu Cys 
            


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-14 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  23

Ala Ala Cys His Ile Asn Arg Ile Ser Met Pro Pro Ser Asp Ile Val 
1               5                   10                  15      


Asp Phe Cys 
            


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-15 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  24

Ala Ala Cys His His Asn Asn Leu Ser Met Pro Pro Ser Asp Tyr Phe 
1               5                   10                  15      


Val Leu Cys 
            


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-16 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  25

Ala Ala Cys Asn Asp Asn Asn Ile Ser Met Pro Pro Ser Ile Val Phe 
1               5                   10                  15      


Asp Phe Cys 
            


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-17 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  26

Ala Ala Cys Ile Val Asn Tyr His Ser Met Pro Pro Ser Leu Asn Ile 
1               5                   10                  15      


Leu Tyr Cys 
            


<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-18 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  27

Ala Ala Cys His Leu His Ile Leu Ser Met Pro Pro Ser Val Tyr Ile 
1               5                   10                  15      


Phe Leu Cys 
            


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA 2.8-19 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  28

Ala Ala Cys Asn Phe Leu Val Asp Ser Met Pro Pro Ser Leu Phe Val 
1               5                   10                  15      


Ile Ile Cys 
            


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE 3-3 SYNTHETIC CORE POLYPEPTIDE SEQUENCE

<400>  29

Ala Ala Cys Leu His Phe Phe Leu Ser Met Pro Pro Ser His Val Leu 
1               5                   10                  15      


Asp Ile Cys 
            


<210>  30
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  30
gcgcgttggc cgattcatta atgcagtcaa gcccgccgta gcc                         43


<210>  31
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  31
ccagtcggga aacctgtcgt gccagttcac ctagatcctt ttggttcatg tgc              53


<210>  32
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  32
ccgacgccgt agcggccgca ggcagcagcc atcaccatc                              39


<210>  33
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  33
ataatcaaaa tcaccggcgc ctttgcttac gtgaatacta caatgacaag ttg              53


<210>  34
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  34
acgtaagcaa aggcgccggt gattttgatt atgaaaagat ggcaaac                     47


<210>  35
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  35
atggctgctg cctgcggccg ctacggcgtc ggtggcag                               38


<210>  36
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  36
ggttggttca tatggaaagt ccatcatctt gg                                     32


<210>  37
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  37
aagtagttgg taccttattc agtaggccag agac                                   34


<210>  38
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  38
agccggccat ggccatggat tataaggatg acgacgataa attcatgtca gaagaacaac       60

tc                                                                      62


<210>  39
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  39
tccaaacgtg cggccgcgca gtgaacgtta tgtgggatgg ag                          42


<210>  40
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  40
tccaaacgtg cggccgcgca gtgaacgtta ttgtgggatg gag                         43


<210>  41
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  41
agccaggatc cgaattcgat gtcagaagag caactgaagg cattcctcac                  50


<210>  42
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  42
tcccccagcc acaccttcca gctc                                              24


<210>  43
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  n is a, c, g, or t

<400>  43
taaatattgc ggccgcttag carwnrwnrw nrwnggatgg aggcatagar wnrwnrwnrw       60

nrwnacaggc cgctccccca gccacac                                           87


<210>  44
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  44
taaatattgc ggccgcttag tagcawbmwb mwbmwbmwbm wbmwbmwbmw bmwbmwbact       60

gttgtagtga tggtatcccc cagcc                                             85


<210>  45
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 1.1 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  45

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Glu Lys 
        35                  40                  45              


Glu His Arg Gln Thr Leu Ser Asp Asp Asp Leu Glu Gly Val Ala Gly 
    50                  55                  60                  


Gly Phe Phe Cys Val Gln Gly Thr Ala Asn Arg Phe Thr Ile Asn Val 
65                  70                  75                  80  


Cys 
    


<210>  46
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 1.2 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  46

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Pro Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ser 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Ile Thr Thr Lys Leu Asn Leu Ser Glu Glu Glu Leu Glu Gly Val 
    50                  55                  60                  


Ala Gly Ala Met Asp Cys Val Ser Ser Thr Ala Gln Gln Thr Glu Cys 
65                  70                  75                  80  


Arg Pro Gly Gly Pro Arg Ala Ser Tyr Cys Trp Asp Asp Leu Arg 
                85                  90                  95  


<210>  47
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 1.3 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  47

Met Ser Glu Glu Gln Leu Lys Gly Phe Leu Ser Lys Val Gln Ser Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Lys Val Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Glu Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Gly Leu Cys Thr Leu Thr Ser Asn Leu Ala Ala Val Cys Cys Gly Gly 
65                  70                  75                  80  


Cys Arg Arg Ala Thr Ser Glu 
                85          


<210>  48
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 1.4 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  48

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Thr Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Pro Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Gly Ser Ser Tyr Arg Asn Gly Lys Cys Thr Phe Gly Pro Ala Cys Pro 
65                  70                  75                  80  


Ser 
    


<210>  49
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 1.5 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  49

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Val Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Thr 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Leu His Gly Ala 
    50                  55                  60                  


Gly Pro Gly Cys Thr Gly Gly Trp Trp Ala Phe Thr Asp Cys Thr Ala 
65                  70                  75                  80  


Gly Gly Gly Ser Cys Glu Gly 
                85          


<210>  50
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 1.6 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  50

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Val Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Asp Asp Phe Glu Arg 
        35                  40                  45              


Asn Thr His Arg Gln Thr Leu Ser Asp Asp Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly Lys Ser Thr Asn Gly Cys Gly Cys Lys Pro Gly His Thr Leu 
65                  70                  75                  80  


Ser Ser Phe Leu Cys Thr Leu Glu Cys Trp Leu 
                85                  90      


<210>  51
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 1.7 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  51

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Val Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ser Gly Phe Ala Ile Thr Thr Glu Asp Leu Lys Ala 
        35                  40                  45              


His Gln Ala Asn Ser Gln Lys Asn Leu Ser Asp Ala Glu Leu Glu Gly 
    50                  55                  60                  


Val Ala Gly Gly Thr Ile Gly Gly Thr Ile Val Ser Ile Thr Cys Glu 
65                  70                  75                  80  


Thr Cys Asp Leu Leu Val Gly Lys Met Cys 
                85                  90  


<210>  52
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.1 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  52

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Trp Asp Gln 
        35                  40                  45              


Arg Pro Val Arg Thr Leu Ser Asp Glu Glu Leu Glu Gly Ala Ala Gly 
    50                  55                  60                  


Gly Cys Cys Ile Thr Gly Glu Ser Pro Gly Ser Ala Pro Thr Asn Asp 
65                  70                  75                  80  


Tyr Lys Cys Thr Lys Gly Arg Gly Pro Gly Gly Cys Tyr 
                85                  90              


<210>  53
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.2 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  53

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Pro Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Thr Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Lys Glu 
        35                  40                  45              


His Arg Gln Thr Leu Ser Asp Asp Glu Leu Glu Ser Val Ala Gly Gly 
    50                  55                  60                  


Gly Asn Asp Thr Val Ile Thr Lys Glu Tyr Ser Cys Tyr Val Thr Ser 
65                  70                  75                  80  


Asp Lys Gly Cys Cys 
                85  


<210>  54
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.3 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  54

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Lys Glu Lys Leu Lys Ala Ala Lys Ser Pro Glu Asp Val 
            20                  25                  30          


Val Gly Ile Ala Lys Glu His Gly His Glu Phe Thr Ala Asp Lys Ile 
        35                  40                  45              


Ser Gln Leu Ser Glu Glu Glu Leu Glu Gly Val Ala Gly Gly Met Gln 
    50                  55                  60                  


Ala Gly Ser Cys Asn Trp Ile Cys Phe Val Asn Gly Val Tyr Ile Asn 
65                  70                  75                  80  


Asp Gly Arg Met Ala Asn Lys Ala Ile 
                85                  


<210>  55
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.4  SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  55

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Ile Glu Met Thr Asp Asp Glu Leu Glu Gly Val Ala Gly 
    50                  55                  60                  


Gly Gly Cys Gly Leu Gly Ala Arg Arg Glu Thr Ala Gln Cys Trp Leu 
65                  70                  75                  80  


Ser His 
        


<210>  56
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.5 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  56

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Thr Glu Ala Glu Val Lys Ala 
        35                  40                  45              


Tyr Gln Thr Arg Asn Leu Ser Asp Glu Glu Leu Asp Glu Val Ala Gly 
    50                  55                  60                  


Gly Ala Pro Cys Arg Pro Phe Thr Asp Pro Ile Tyr Cys Trp Arg Lys 
65                  70                  75                  80  


Gly Glu Gln Thr Ile Ile Gly Arg Gly Arg Ser Cys Leu Tyr Pro Glu 
                85                  90                  95      


<210>  57
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.6 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  57

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Ser Thr Glu Asp Leu Asn Asn 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Gly Ile Cys Val Tyr Val Asn Cys Val Leu Ser Ile Arg Glu Thr Pro 
65                  70                  75                  80  


Ser Val Ile 
            


<210>  58
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.7 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  58

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Ala Thr Glu Asp Leu Lys Thr 
        35                  40                  45              


His Arg Gln Thr Leu Ser Asp Asp Asp Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Ala Gly Cys Tyr Pro Ile Cys Asp Trp Thr Ser Pro Thr Arg Ser 
65                  70                  75                  


<210>  59
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.8 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  59

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Thr Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ile Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Ala Ala Cys His Asn His Ala Pro Ser Met Pro Pro Ser Tyr Trp Glu 
65                  70                  75                  80  


Gly Glu Cys 
            


<210>  60
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.9 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  60

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Pro Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Lys Thr 
        35                  40                  45              


Ala Arg Gln Thr Leu Ser Asp Asp Asp Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Tyr Glu Asp Gly Asp Tyr Thr Lys Ser Ile Ser Ile Val Val Ala Cys 
65                  70                  75                  80  


Cys Arg Phe 
            


<210>  61
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.10 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  61

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Pro Val Ser 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Glu Glu Leu Glu Gly Ala Ala Gly Gly 
    50                  55                  60                  


Ala Gly Gly Thr Ile Pro Ser Leu Met Thr Gly Cys Gly Trp Leu Thr 
65                  70                  75                  80  


Gly Leu Cys Val Arg 
                85  


<210>  62
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 2.11 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  62

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Thr Lys Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Thr Leu Ser Glu Asp Glu Leu Glu Ser Val Ala Gly Gly 
    50                  55                  60                  


Gly Arg Ile Asp Thr Cys Pro Ala Gly Gly Gly Thr Ser Glu Gln Thr 
65                  70                  75                  80  


Gly Thr Cys Cys 
                


<210>  63
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 3.1 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  63

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Arg Thr Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Gly Gly Lys Met Thr Val Arg Gly Arg Asp Met Ser Cys Gly Cys Gln 
65                  70                  75                  80  


Asp Tyr Trp Glu Asp Asp Tyr 
                85          


<210>  64
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 3.2 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  64

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Arg Thr Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Gly Gly Cys Asp Gly Ile Arg Ile Thr Asp Lys Gln Thr Val Ala Asp 
65                  70                  75                  80  


Asn Thr Ile Val Pro Cys Ser Cys Phe His Gln 
                85                  90      


<210>  65
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 3.3 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  65

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Gly Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Lys Gln Gln Asp Leu Asn Ala 
        35                  40                  45              


Ala Ala Ser Glu Leu Ser Asp Glu Glu Leu Glu Ala Ala Ser Gly Gly 
    50                  55                  60                  


Gly Asp Thr Gly Ile Gln Ala Val Leu His Thr Ala Gly Cys Tyr Gly 
65                  70                  75                  80  


Gly Thr Lys Met Cys Arg Ala 
                85          


<210>  66
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 3.4 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  66

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Thr 
        35                  40                  45              


His Arg Gln Thr Leu Ser Asp Arg Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Thr Thr Ala Phe Thr Gly Val Asp Thr Glu Ser Ile Ala Phe Cys Cys 
65                  70                  75                  80  


Ser 
    


<210>  67
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 3.5 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  67

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ser Asp Ala Val 
            20                  25                  30          


Leu Val Ile Ala Lys Asp Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Lys Asn Ala Gln Ser Glu Ile Ser Glu Glu Glu Leu Glu Ser Val Ala 
    50                  55                  60                  


Gly Gly Ala Gly Val Thr Glu Ala Thr Ile Asp Ala Gly Gly Gly Cys 
65                  70                  75                  80  


Thr Phe Asn Pro Cys Cys Arg 
                85          


<210>  68
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 4.1 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  68

Met Ser Glu Glu Gln Leu Lys Ala Leu Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Lys Glu 
        35                  40                  45              


His Arg Gln Thr Leu Ser Val Gly Arg Gln Thr Leu Ser Glu Ser Glu 
    50                  55                  60                  


Leu Glu Gly Leu Ala Gly Gly Gly Gly Gly Ala Arg Thr Lys Thr Ala 
65                  70                  75                  80  


Asn Val Pro Ser Asp Leu Pro Val Arg Ala Pro Ala Met Ser Thr Phe 
                85                  90                  95      


Ala Glu Asn Gln Thr 
            100     


<210>  69
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 4.2 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  69

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Pro Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Lys Glu 
        35                  40                  45              


His Arg Gln Ala Leu Ser Asp Asp Asp Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Thr Ile Val Thr Val Thr Gly Ala Leu Ile Ser Ile Ala Ala Glu Cys 
65                  70                  75                  80  


<210>  70
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 4.3 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  70

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Thr Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Thr Ala Ser Gly Gly Cys Asp Thr Ser Met Phe Cys Tyr 
65                  70                  75          


<210>  71
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA 4.4 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  71

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Gln Ala Ala Ala Asp Ser Asp Ala Val 
            20                  25                  30          


Leu Ala Ile Ala Lys Glu Ala Gly Phe Met Ile Ser Ala Asp Glu Leu 
        35                  40                  45              


Lys Lys Ala Gln Ser Glu Ile Ser Glu Glu Glu Leu Glu Ser Ala Ala 
    50                  55                  60                  


Gly Gly Arg Leu Lys Ser Gly Cys His Cys Gly Thr Val Ile Arg Ser 
65                  70                  75                  80  


Tyr Ser Lys Tyr Cys 
                85  


<210>  72
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA S.1 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  72

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ser Asp Ala Val 
            20                  25                  30          


Leu Val Ile Ala Lys Asp Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Lys Asn Ala Gln Ser Glu Ile Ser Glu Glu Glu Leu Glu Ser Val Ala 
    50                  55                  60                  


Gly Gly Ala Gln Ser Ala Gly Gly Cys Gly Ile Cys Glu Cys Asp Asn 
65                  70                  75                  80  


Arg Gln Ser Thr Ser Cys His Tyr Pro Ser His Gly 
                85                  90          


<210>  73
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA S.2 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  73

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Gly Ser Asp Ala Val 
            20                  25                  30          


Leu Ala Ile Ala Lys Ala Ala Gly Leu Met Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Thr Lys Ala Gln Ser Glu Ile Ser Asp Ala Glu Leu Glu Asp Ala Ala 
    50                  55                  60                  


Gly Gly Gly Ala Gln Gly Pro Ala Cys Cys Ala Ala Met Glu Ser Ser 
65                  70                  75                  80  


Asp Thr Arg Cys Gly Trp Val Ser Trp Val Leu Ser Glu Val Val Pro 
                85                  90                  95      


Pro Gln 
        


<210>  74
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProcA T.1 SYNTHETIC LEADER POLYPEPTIDE SEQUENCE

<400>  74

Met Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Ile Ala Ile Ala 
1               5                   10                  15      


Lys Ala Ala Gly Phe Ser Ile Thr Ile Glu Asp Leu Lys Glu His Arg 
            20                  25                  30          


Lys Thr Leu Ser Asp Ala Glu Leu Glu Gly Leu Ala Gly Gly Ala Phe 
        35                  40                  45              


Asn His Asp Trp Gly Gln Thr Thr Arg Asn Tyr Lys Cys Glu Thr Ser 
    50                  55                  60                  


Tyr Cys Cys 
65          


<210>  75
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC LIBRARY 1 ProA 2.8 LEADER POLYPEPTIDE SEQUENCE


<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  75

Ala Ala Cys Xaa Xaa Xaa Xaa Xaa Ser Met Pro Pro Ser Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Cys 
            


<210>  76
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC LIBRARY 2 ProA 2.8 LEADER POLYPEPTIDE SEQUENCE


<220>
<221>  misc_feature
<222>  (7)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  76

Tyr His His Tyr Asn Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Cys Tyr 
            20  


<210>  77
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC ProcA 2.8 LEADER POLYPEPTIDE SEQUENCE

<400>  77

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Thr Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ile Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  78
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2.8-1 POLYPEPTIDE SEQUENCE

<400>  78

Ala Ala Cys Phe Asn Val His Ile Ser Met Pro Pro Ser His Asn Asn 
1               5                   10                  15      


Val His Cys 
            


<210>  79
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2.8-10 POLYPEPTIDE SEQUENCE

<400>  79

Ala Ala Cys Val Asn His Leu Leu Ser Met Pro Pro Ser Leu Asn Asp 
1               5                   10                  15      


Leu Asn Cys 
            


<210>  80
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2.8-11 POLYPEPTIDE SEQUENCE

<400>  80

Ala Ala Cys Asp Val Asn Leu His Ser Met Pro Pro Ser Leu Asp Phe 
1               5                   10                  15      


Phe Val Cys 
            


<210>  81
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2.8-15 POLYPEPTIDE SEQUENCE

<400>  81

Ala Ala Cys Val Phe His Phe Asp Ser Met Pro Pro Ser Tyr Leu Asp 
1               5                   10                  15      


Asp Asp Cys 
            


<210>  82
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2.8-3 POLYPEPTIDE SEQUENCE

<400>  82

Ala Ala Cys Asn Ile Asp Phe Leu Ser Met Pro Pro Ser Ile His His 
1               5                   10                  15      


Ile Leu Cys 
            


<210>  83
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2.8-5 POLYPEPTIDE SEQUENCE

<400>  83

Ala Ala Cys Asn Ile Tyr Tyr Ile Ser Met Pro Pro Ser His His Phe 
1               5                   10                  15      


Val Tyr Cys 
            


<210>  84
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC HIT 3-3 POLYPEPTIDE SEQUENCE

<400>  84

Ala Ala Cys Leu His Phe Phe Leu Ser Met Pro Pro Ser His Val Leu 
1               5                   10                  15      


Asp Ile Cys 
            


<210>  85
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2C10 POLYPEPTIDE SEQUENCE

<400>  85

Tyr His His Tyr Asn Cys Tyr Asn Phe Asn Leu Phe Asn Asn Tyr Asn 
1               5                   10                  15      


Asn Asn Ser Tyr 
            20  


<210>  86
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2C10S POLYPEPTIDE SEQUENCE

<400>  86

Tyr His His Tyr Asn Ser Tyr Asn Phe Asn Leu Phe Asn Asn Tyr Asn 
1               5                   10                  15      


Asn Asn Cys Tyr 
            20  


<210>  87
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2C10-3 POLYPEPTIDE SEQUENCE

<400>  87

Tyr His His Tyr Asn Ser Asp Val Leu Leu Asp Leu Lys Lys Asn Asp 
1               5                   10                  15      


Leu Glu Cys Tyr 
            20  


<210>  88
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2C10-10 POLYPEPTIDE SEQUENCE

<400>  88

Tyr His His Tyr Asn Ser Val Ile Asn His Leu Asn Asp Leu Gln Glu 
1               5                   10                  15      


Lys Leu Cys Tyr 
            20  


<210>  89
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2C10-11 POLYPEPTIDE SEQUENCE

<400>  89

Tyr His His Tyr Asn Ser Gln Gln Val Val Ile Ile Gln Asp Asn Gln 
1               5                   10                  15      


Val Asp Cys Tyr 
            20  


<210>  90
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC 2C10-14 POLYPEPTIDE SEQUENCE

<400>  90

Tyr His His Tyr Asn Ser Met Ile Lys His Lys Glu His Asp His Met 
1               5                   10                  15      


Ile Ile Cys Tyr 
            20  


<210>  91
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  91
ttggtctcat ccacaattcg aaaaactgca ggctagtggt ggtgg                       45


<210>  92
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  92
cgaattgtgg atgagaccaa ttggatctac cttcaatcgt cgagctattg tcc              53


<210>  93
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  93
ttatatttcc agggtagcca gcaggaactg acaactatat gcg                         43


<210>  94
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  94
gcagcggttt ctttaccaga ctcgatcaca aacattcacc ttccc                       45


<210>  95
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONULCEOTIDE

<400>  95
tggtgccgcg cggcagccat caggaactga caactatatg cgag                        44


<210>  96
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  96
tgtcgacgga gctcgaattc ttagcactgg cttgtacact ttg                         43


<210>  97
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  97
ctttaagaag gagatatacc atgaaggaac aaaactcctt caacttg                     47


<210>  98
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  98
ggtggtggtg gtgctcgagt tcagtgatga tgatggtggt ggtg                        44


<210>  99
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  99
atttcacacg agctcggtac ccgggccaga cgtaatctaa taaggaggta c                51


<210>  100
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  100
tcttctctca tccgccaaaa cagccttaat caacatatgg cattaagact cc               52


<210>  101
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  101
caatttcaca cgagctcagg agatatacca tggaaagtcc atcatcttgg aaaac            55


<210>  102
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  102
tccgccaaaa cagccttatt cagtaggcca gagaccag                               38


<210>  103
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  103
agctcggtac ccggggatcc caggagatat accatgaaaa ctcctctaac aagtg            55


<210>  104
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC OLIGONUCLEOTIDE

<400>  104
tctcatccgc caaaacagcc aagcttttat ctgtcatgaa ttctcaactc                  50


<210>  105
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC LACTINCIN 481 POLYPEPTIDE SEQUENCE


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is dehydrobutyrine (Dhb).

<400>  105

Lys Gly Gly Ser Gly Val Ile His Xaa Ile Ala His Glu Ala Asn Met 
1               5                   10                  15      


Asn Ala Trp Gln Phe Val Phe Xaa Ala Ala Ser 
            20                  25          


<210>  106
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC Cinnamycin POLYPEPTIDE SEQUENCE


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is Abu.

<400>  106

Lys Xaa Asn Gly Asp Ala Val Phe Xaa Phe Pro Gly Phe Ala Ala Ala 
1               5                   10                  15      


Gln Arg Ala 
            


<210>  107
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC Haloduracin alpha SYNTHETIC POLYPEPTIDE


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is Abu.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is Abu.

<400>  107

Ala Ile Asn Tyr Trp Ala Arg Leu Gly Asn Lys Gly Ala Tyr Ala Xaa 
1               5                   10                  15      


Leu Xaa Val Glu Ala Met Pro Ser Ala Asn 
            20                  25      


