                         SEQUENCE LISTING

<110>  Merial, Inc.
       AUDONNET, Jean-Christophe
       MEBATSION, Teshome
       HANNAS, Zahia
       CHIANG, Yu-Wei
       WIDENER, Justin
 
<120>  FMDV RECOMBINANT VACCINES AND USES THEREOF

<130>  MER 14-244

<150>  62/054,073
<151>  2014-09-23

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  2333
<212>  PRT
<213>  artificial sequence

<220>
<223>  Wild-type polyprotein of A24 Cruzeiro Strain (GenBank AAT01711)

<400>  1

Met Asn Thr Thr Asp Cys Phe Ile Ala Leu Val His Ala Ile Arg Glu 
1               5                   10                  15      


Ile Arg Ala Phe Phe Leu Pro Arg Ala Thr Gly Arg Met Glu Phe Thr 
            20                  25                  30          


Leu His Asn Gly Glu Arg Lys Val Phe Tyr Ser Arg Pro Asn Asn His 
        35                  40                  45              


Asp Asn Cys Trp Leu Asn Thr Ile Leu Gln Leu Phe Arg Tyr Val Gly 
    50                  55                  60                  


Glu Pro Phe Phe Asp Trp Val Tyr Asp Ser Pro Glu Asn Leu Thr Leu 
65                  70                  75                  80  


Glu Ala Ile Glu Gln Leu Glu Glu Leu Thr Gly Leu Glu Leu His Glu 
                85                  90                  95      


Gly Gly Pro Pro Ala Leu Val Ile Trp Asn Ile Lys His Leu Leu His 
            100                 105                 110         


Thr Gly Ile Gly Thr Ala Ser Arg Pro Ser Glu Val Cys Met Val Asp 
        115                 120                 125             


Gly Thr Asn Met Cys Leu Ala Asp Phe His Ala Gly Ile Phe Leu Lys 
    130                 135                 140                 


Gly Gln Glu His Ala Val Phe Ala Cys Val Thr Ser Asn Gly Trp Tyr 
145                 150                 155                 160 


Ala Ile Asp Asp Glu Asp Phe Tyr Pro Trp Thr Pro Asp Pro Ser Asp 
                165                 170                 175     


Val Leu Val Phe Val Pro Tyr Asp Gln Glu Pro Leu Asn Gly Glu Trp 
            180                 185                 190         


Lys Thr Lys Val Gln Gln Lys Leu Lys Gly Ala Gly Gln Ser Ser Pro 
        195                 200                 205             


Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn Thr Gly Ser Ile Ile Asn 
    210                 215                 220                 


Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser Met Asp Thr Gln Leu Gly 
225                 230                 235                 240 


Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu Gly Ser Thr Asp Thr Thr 
                245                 250                 255     


Ser Thr His Thr Thr Asn Thr Gln Asn Asn Asp Trp Phe Ser Lys Leu 
            260                 265                 270         


Ala Ser Ser Ala Phe Thr Gly Leu Phe Gly Ala Leu Leu Ala Asp Lys 
        275                 280                 285             


Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Leu Thr Thr Arg 
    290                 295                 300                 


Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val Gly Val Thr His 
305                 310                 315                 320 


Gly Tyr Ser Thr Glu Glu Asp His Val Ala Gly Pro Asn Thr Ser Gly 
                325                 330                 335     


Leu Glu Thr Arg Val Val Gln Ala Glu Arg Phe Tyr Lys Lys Tyr Leu 
            340                 345                 350         


Phe Asp Trp Thr Thr Asp Lys Ala Phe Gly His Leu Glu Lys Leu Glu 
        355                 360                 365             


Leu Pro Ser Asp His His Gly Val Phe Gly His Leu Val Asp Ser Tyr 
    370                 375                 380                 


Ala Tyr Met Arg Asn Gly Trp Asp Val Glu Val Ser Ala Val Gly Asn 
385                 390                 395                 400 


Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Met Val Pro Glu Trp Lys 
                405                 410                 415     


Glu Phe Asp Thr Arg Glu Lys Tyr Gln Leu Thr Leu Phe Pro His Gln 
            420                 425                 430         


Phe Ile Ser Pro Arg Thr Asn Met Thr Ala His Ile Thr Val Pro Tyr 
        435                 440                 445             


Leu Gly Val Asn Arg Tyr Asp Gln Tyr Lys Lys His Lys Pro Trp Thr 
    450                 455                 460                 


Leu Val Val Met Val Val Ser Pro Leu Thr Val Asn Asn Thr Ser Ala 
465                 470                 475                 480 


Ala Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr Tyr Val His Val 
                485                 490                 495     


Ala Gly Glu Leu Pro Ser Lys Glu Gly Ile Phe Pro Val Ala Cys Ala 
            500                 505                 510         


Asp Gly Tyr Gly Gly Leu Val Thr Thr Asp Pro Lys Thr Ala Asp Pro 
        515                 520                 525             


Ala Tyr Gly Lys Val Tyr Asn Pro Pro Arg Thr Asn Tyr Pro Gly Arg 
    530                 535                 540                 


Phe Thr Asn Leu Leu Asp Val Ala Glu Ala Cys Pro Thr Phe Leu Cys 
545                 550                 555                 560 


Phe Asp Asp Gly Lys Pro Tyr Val Thr Thr Arg Thr Asp Asp Thr Arg 
                565                 570                 575     


Leu Leu Ala Lys Phe Asp Leu Ser Leu Ala Ala Lys His Met Ser Asn 
            580                 585                 590         


Thr Tyr Leu Ser Gly Ile Ala Gln Tyr Tyr Thr Gln Tyr Ser Gly Thr 
        595                 600                 605             


Ile Asn Leu His Phe Met Phe Thr Gly Ser Thr Asp Ser Lys Ala Arg 
    610                 615                 620                 


Tyr Met Val Ala Tyr Ile Pro Pro Gly Val Glu Thr Pro Pro Asp Thr 
625                 630                 635                 640 


Pro Glu Arg Ala Ala His Cys Ile His Ala Glu Trp Asp Thr Gly Leu 
                645                 650                 655     


Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Val Ser Ala Ala Asp Tyr 
            660                 665                 670         


Ala Tyr Thr Ala Ser Asp Thr Ala Glu Thr Ile Asn Val Gln Gly Trp 
        675                 680                 685             


Val Cys Ile Tyr Gln Ile Thr His Gly Lys Ala Glu Asn Asp Thr Leu 
    690                 695                 700                 


Val Val Ser Val Ser Ala Gly Lys Asp Phe Glu Leu Arg Leu Pro Ile 
705                 710                 715                 720 


Asp Pro Arg Gln Gln Thr Thr Ala Thr Gly Glu Ser Ala Asp Pro Val 
                725                 730                 735     


Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln Ile Gln Arg Arg 
            740                 745                 750         


His His Thr Asp Ile Gly Phe Ile Met Asp Arg Phe Val Lys Ile Gln 
        755                 760                 765             


Ser Leu Ser Pro Thr His Val Ile Asp Leu Met Gln Thr His Gln His 
    770                 775                 780                 


Gly Leu Val Gly Ala Leu Leu Arg Ala Ala Thr Tyr Tyr Phe Ser Asp 
785                 790                 795                 800 


Leu Glu Ile Val Val Arg His Glu Gly Asn Leu Thr Trp Val Pro Asn 
                805                 810                 815     


Gly Ala Pro Glu Ser Ala Leu Leu Asn Thr Ser Asn Pro Thr Ala Tyr 
            820                 825                 830         


Asn Lys Ala Pro Phe Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His 
        835                 840                 845             


Arg Val Leu Ala Thr Val Tyr Asn Gly Thr Ser Lys Tyr Ala Val Gly 
    850                 855                 860                 


Gly Ser Gly Arg Arg Gly Asp Met Gly Ser Leu Ala Ala Arg Val Val 
865                 870                 875                 880 


Lys Gln Leu Pro Ala Ser Phe Asn Tyr Gly Ala Ile Lys Ala Asp Ala 
                885                 890                 895     


Ile His Glu Leu Leu Val Arg Met Lys Arg Ala Glu Leu Tyr Cys Pro 
            900                 905                 910         


Arg Pro Leu Leu Ala Ile Glu Val Ser Ser Gln Asp Arg His Lys Gln 
        915                 920                 925             


Lys Ile Ile Ala Pro Ala Lys Gln Leu Leu Asn Phe Asp Leu Leu Lys 
    930                 935                 940                 


Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Phe Phe Phe Ser Asp 
945                 950                 955                 960 


Val Arg Ser Asn Phe Ser Lys Leu Val Asp Thr Ile Asn Gln Met Gln 
                965                 970                 975     


Glu Asp Met Ser Thr Lys His Gly Pro Asp Phe Asn Arg Leu Val Ser 
            980                 985                 990         


Ala Phe Glu Glu Leu Ala Thr Gly  Val Lys Ala Ile Arg  Thr Gly Leu 
        995                 1000                 1005             


Asp Glu  Ala Lys Pro Trp Tyr  Lys Leu Ile Lys Leu  Leu Ser Arg 
    1010                 1015                 1020             


Leu Ser  Cys Met Ala Ala Val  Ala Ala Arg Ser Lys  Asp Pro Val 
    1025                 1030                 1035             


Leu Val  Ala Ile Met Leu Ala  Asp Thr Gly Leu Glu  Ile Leu Asp 
    1040                 1045                 1050             


Ser Thr  Phe Val Val Lys Lys  Ile Ser Asp Ser Leu  Ser Ser Leu 
    1055                 1060                 1065             


Phe His  Val Pro Ala Pro Val  Phe Ser Phe Gly Ala  Pro Ile Leu 
    1070                 1075                 1080             


Leu Ala  Gly Leu Val Lys Val  Ala Ser Ser Phe Phe  Arg Ser Thr 
    1085                 1090                 1095             


Pro Glu  Asp Leu Glu Arg Ala  Glu Lys Gln Leu Lys  Ala Arg Asp 
    1100                 1105                 1110             


Ile Asn  Asp Ile Phe Ala Ile  Leu Lys Asn Gly Glu  Trp Leu Val 
    1115                 1120                 1125             


Lys Leu  Ile Leu Ala Ile Arg  Asp Trp Ile Lys Ala  Trp Ile Ala 
    1130                 1135                 1140             


Ser Glu  Glu Lys Phe Val Thr  Thr Thr Asp Leu Val  Pro Gly Ile 
    1145                 1150                 1155             


Leu Glu  Lys Gln Arg Asp Leu  Asn Asp Pro Ser Lys  Tyr Lys Glu 
    1160                 1165                 1170             


Ala Lys  Glu Trp Leu Asp Asn  Ala Arg Gln Ala Cys  Leu Lys Ser 
    1175                 1180                 1185             


Gly Asn  Val His Ile Ala Asn  Leu Cys Lys Val Val  Ala Pro Ala 
    1190                 1195                 1200             


Pro Ser  Arg Ser Arg Pro Glu  Pro Val Val Val Cys  Leu Arg Gly 
    1205                 1210                 1215             


Lys Ser  Gly Gln Gly Lys Ser  Phe Leu Ala Asn Val  Leu Ala Gln 
    1220                 1225                 1230             


Ala Ile  Ser Thr His Phe Thr  Gly Arg Thr Asp Ser  Val Trp Tyr 
    1235                 1240                 1245             


Cys Pro  Pro Asp Pro Asp His  Phe Asp Gly Tyr Asn  Gln Gln Thr 
    1250                 1255                 1260             


Val Val  Val Met Asp Asp Leu  Gly Gln Asn Pro Asp  Gly Lys Asp 
    1265                 1270                 1275             


Phe Lys  Tyr Phe Ala Gln Met  Val Ser Thr Thr Gly  Phe Ile Pro 
    1280                 1285                 1290             


Pro Met  Ala Ser Leu Glu Asp  Lys Gly Lys Pro Phe  Asn Ser Lys 
    1295                 1300                 1305             


Val Ile  Ile Ala Thr Thr Asn  Leu Tyr Ser Gly Phe  Thr Pro Arg 
    1310                 1315                 1320             


Thr Met  Val Cys Pro Asp Ala  Leu Asn Arg Arg Phe  His Phe Asp 
    1325                 1330                 1335             


Ile Asp  Val Ser Ala Lys Asp  Gly Tyr Lys Ile Asn  Asn Lys Leu 
    1340                 1345                 1350             


Asp Ile  Ile Lys Ala Leu Glu  Asp Thr His Thr Asn  Pro Val Ala 
    1355                 1360                 1365             


Met Phe  Gln Tyr Asp Cys Ala  Leu Leu Asn Gly Met  Ala Val Glu 
    1370                 1375                 1380             


Met Lys  Arg Met Gln Gln Asp  Met Phe Lys Pro Gln  Pro Pro Leu 
    1385                 1390                 1395             


Gln Asn  Val Tyr Gln Leu Val  Gln Glu Val Ile Glu  Arg Val Glu 
    1400                 1405                 1410             


Leu His  Glu Lys Val Ser Ser  His Pro Ile Phe Lys  Gln Ile Ser 
    1415                 1420                 1425             


Ile Pro  Ser Gln Lys Ser Val  Leu Tyr Phe Leu Ile  Glu Lys Gly 
    1430                 1435                 1440             


Gln His  Glu Ala Ala Ile Glu  Phe Phe Glu Gly Met  Val His Asp 
    1445                 1450                 1455             


Ser Ile  Lys Glu Glu Leu Arg  Pro Leu Ile Gln Gln  Thr Ser Phe 
    1460                 1465                 1470             


Val Lys  Arg Ala Phe Lys Arg  Leu Lys Glu Asn Phe  Glu Ile Val 
    1475                 1480                 1485             


Ala Leu  Cys Leu Thr Leu Leu  Ala Asn Ile Val Ile  Met Ile Arg 
    1490                 1495                 1500             


Glu Thr  Arg Lys Arg Gln Lys  Met Val Asp Asp Ala  Val Ser Glu 
    1505                 1510                 1515             


Tyr Ile  Glu Arg Ala Asn Ile  Thr Thr Asp Asp Lys  Thr Leu Asp 
    1520                 1525                 1530             


Glu Ala  Glu Lys Asn Pro Leu  Glu Thr Ser Gly Ala  Ser Thr Val 
    1535                 1540                 1545             


Gly Phe  Arg Glu Arg Pro Leu  Pro Gly Gln Lys Ala  Arg Asn Asp 
    1550                 1555                 1560             


Glu Asn  Ser Glu Pro Ala Gln  Pro Ala Glu Glu Gln  Pro Gln Ala 
    1565                 1570                 1575             


Glu Gly  Pro Tyr Ala Gly Pro  Leu Glu Arg Gln Lys  Pro Leu Lys 
    1580                 1585                 1590             


Val Arg  Ala Lys Leu Pro Gln  Gln Glu Gly Pro Tyr  Ala Gly Pro 
    1595                 1600                 1605             


Met Glu  Arg Gln Lys Pro Leu  Lys Val Lys Ala Lys  Ala Pro Val 
    1610                 1615                 1620             


Val Lys  Glu Gly Pro Tyr Glu  Gly Pro Val Lys Lys  Pro Val Ala 
    1625                 1630                 1635             


Leu Lys  Val Lys Ala Lys Asn  Leu Ile Val Thr Glu  Ser Gly Ala 
    1640                 1645                 1650             


Pro Pro  Thr Asp Leu Gln Lys  Leu Val Met Gly Asn  Thr Lys Pro 
    1655                 1660                 1665             


Val Glu  Leu Ile Leu Asp Gly  Lys Thr Val Ala Ile  Cys Cys Ala 
    1670                 1675                 1680             


Thr Gly  Val Phe Gly Thr Ala  Tyr Leu Val Pro Arg  His Leu Phe 
    1685                 1690                 1695             


Ala Glu  Lys Tyr Asp Lys Ile  Met Leu Asp Gly Arg  Ala Met Thr 
    1700                 1705                 1710             


Asp Ser  Asp Tyr Arg Val Phe  Glu Phe Glu Ile Lys  Val Lys Gly 
    1715                 1720                 1725             


Gln Asp  Met Leu Ser Asp Ala  Ala Leu Met Val Leu  His Arg Gly 
    1730                 1735                 1740             


Asn Arg  Val Arg Asp Ile Thr  Lys His Phe Arg Asp  Thr Ala Arg 
    1745                 1750                 1755             


Met Lys  Lys Gly Thr Pro Val  Val Gly Val Ile Asn  Asn Ala Asp 
    1760                 1765                 1770             


Val Gly  Arg Leu Ile Phe Ser  Gly Glu Ala Leu Thr  Tyr Lys Asp 
    1775                 1780                 1785             


Ile Val  Val Cys Met Asp Gly  Asp Thr Met Pro Gly  Leu Phe Ala 
    1790                 1795                 1800             


Tyr Lys  Ala Ala Thr Lys Ala  Gly Tyr Cys Gly Gly  Ala Val Leu 
    1805                 1810                 1815             


Ala Lys  Asp Gly Ala Asp Thr  Phe Ile Val Gly Thr  His Ser Ala 
    1820                 1825                 1830             


Gly Gly  Asn Gly Val Gly Tyr  Cys Ser Cys Val Ser  Arg Ser Met 
    1835                 1840                 1845             


Leu Leu  Lys Met Lys Ala His  Val Asp Pro Glu Pro  His His Glu 
    1850                 1855                 1860             


Gly Leu  Ile Val Asp Thr Arg  Asp Val Glu Glu Arg  Val His Val 
    1865                 1870                 1875             


Met Arg  Lys Thr Lys Leu Ala  Pro Thr Val Ala His  Gly Val Phe 
    1880                 1885                 1890             


Asn Pro  Glu Phe Gly Pro Ala  Ala Leu Ser Asn Lys  Asp Pro Arg 
    1895                 1900                 1905             


Leu Asn  Asp Gly Val Val Leu  Asp Glu Val Ile Phe  Ser Lys His 
    1910                 1915                 1920             


Lys Gly  Asp Thr Lys Met Ser  Glu Glu Asp Lys Ala  Leu Phe Arg 
    1925                 1930                 1935             


Arg Cys  Ala Ala Asp Tyr Ala  Ser Arg Leu His Ser  Val Leu Gly 
    1940                 1945                 1950             


Thr Ala  Asn Ala Pro Leu Ser  Ile Tyr Glu Ala Ile  Lys Gly Val 
    1955                 1960                 1965             


Asp Gly  Leu Asp Ala Met Glu  Pro Asp Thr Ala Pro  Gly Leu Pro 
    1970                 1975                 1980             


Trp Ala  Leu Gln Gly Lys Arg  Arg Gly Ala Leu Ile  Asp Phe Glu 
    1985                 1990                 1995             


Asn Gly  Thr Val Gly Pro Glu  Val Glu Ala Ala Leu  Lys Leu Met 
    2000                 2005                 2010             


Glu Lys  Arg Glu Tyr Lys Phe  Ala Cys Gln Thr Phe  Leu Lys Asp 
    2015                 2020                 2025             


Glu Ile  Arg Pro Met Glu Lys  Val Arg Ala Gly Lys  Thr Arg Ile 
    2030                 2035                 2040             


Val Asp  Val Leu Pro Val Glu  His Ile Leu Tyr Thr  Arg Met Met 
    2045                 2050                 2055             


Ile Gly  Arg Phe Cys Ala Gln  Met His Ser Asn Asn  Gly Pro Gln 
    2060                 2065                 2070             


Ile Gly  Ser Ala Val Gly Cys  Asn Pro Asp Val Asp  Trp Gln Arg 
    2075                 2080                 2085             


Phe Gly  Thr His Phe Ala Gln  Tyr Arg Asn Val Trp  Asp Val Asp 
    2090                 2095                 2100             


Tyr Ser  Ala Phe Asp Ala Asn  His Cys Ser Asp Ala  Met Asn Ile 
    2105                 2110                 2115             


Met Phe  Glu Glu Val Phe Arg  Thr Glu Phe Gly Phe  His Pro Asn 
    2120                 2125                 2130             


Ala Glu  Trp Ile Leu Lys Thr  Leu Val Asn Thr Glu  His Ala Tyr 
    2135                 2140                 2145             


Glu Asn  Lys Arg Ile Thr Val  Glu Gly Gly Met Pro  Ser Gly Cys 
    2150                 2155                 2160             


Ser Ala  Thr Ser Ile Ile Asn  Thr Ile Leu Asn Asn  Ile Tyr Val 
    2165                 2170                 2175             


Leu Tyr  Ala Leu Arg Arg His  Tyr Glu Gly Val Glu  Leu Asp Thr 
    2180                 2185                 2190             


Tyr Thr  Met Ile Ser Tyr Gly  Asp Asp Ile Val Val  Ala Ser Asp 
    2195                 2200                 2205             


Tyr Asp  Leu Asp Phe Glu Ala  Leu Lys Pro His Phe  Lys Ser Leu 
    2210                 2215                 2220             


Gly Gln  Thr Ile Thr Pro Ala  Asp Lys Ser Asp Lys  Gly Phe Val 
    2225                 2230                 2235             


Leu Gly  His Ser Ile Thr Asp  Val Thr Phe Leu Lys  Arg His Phe 
    2240                 2245                 2250             


His Met  Asp Tyr Gly Thr Gly  Phe Tyr Lys Pro Val  Met Ala Ser 
    2255                 2260                 2265             


Lys Thr  Leu Glu Ala Ile Leu  Ser Phe Ala Arg Arg  Gly Thr Ile 
    2270                 2275                 2280             


Gln Glu  Lys Leu Ile Ser Val  Ala Gly Leu Ala Val  His Ser Gly 
    2285                 2290                 2295             


Pro Asp  Glu Tyr Arg Arg Leu  Phe Glu Pro Phe Gln  Gly Leu Phe 
    2300                 2305                 2310             


Glu Ile  Pro Ser Tyr Arg Ser  Leu Tyr Leu Arg Trp  Val Asn Ala 
    2315                 2320                 2325             


Val Cys  Gly Asp Ala 
    2330             


<210>  2
<211>  1126
<212>  PRT
<213>  artificial sequence

<220>
<223>  Modified polyprotein of A24 Cruzeiro Strain in VP2 (H93C) or P1 
       (H179C)

<400>  2

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Thr Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu 
                85                  90                  95      


Glu Asp Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr 
            100                 105                 110         


Gln Ser Ser Val Gly Val Thr His Gly Tyr Ser Thr Glu Glu Asp His 
        115                 120                 125             


Val Ala Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala 
    130                 135                 140                 


Glu Arg Phe Tyr Lys Lys Tyr Leu Phe Asp Trp Thr Thr Asp Lys Ala 
145                 150                 155                 160 


Phe Gly His Leu Glu Lys Leu Glu Leu Pro Ser Asp His His Gly Val 
                165                 170                 175     


Phe Gly Cys Leu Val Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp 
            180                 185                 190         


Val Glu Val Ser Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu 
        195                 200                 205             


Val Ala Met Val Pro Glu Trp Lys Glu Phe Asp Thr Arg Glu Lys Tyr 
    210                 215                 220                 


Gln Leu Thr Leu Phe Pro His Gln Phe Ile Ser Pro Arg Thr Asn Met 
225                 230                 235                 240 


Thr Ala His Ile Thr Val Pro Tyr Leu Gly Val Asn Arg Tyr Asp Gln 
                245                 250                 255     


Tyr Lys Lys His Lys Pro Trp Thr Leu Val Val Met Val Val Ser Pro 
            260                 265                 270         


Leu Thr Val Asn Asn Thr Ser Ala Ala Gln Ile Lys Val Tyr Ala Asn 
        275                 280                 285             


Ile Ala Pro Thr Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu 
    290                 295                 300                 


Gly Ile Phe Pro Val Ala Cys Ala Asp Gly Tyr Gly Gly Leu Val Thr 
305                 310                 315                 320 


Thr Asp Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val Tyr Asn Pro 
                325                 330                 335     


Pro Arg Thr Asn Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala 
            340                 345                 350         


Glu Ala Cys Pro Thr Phe Leu Cys Phe Asp Asp Gly Lys Pro Tyr Val 
        355                 360                 365             


Thr Thr Arg Thr Asp Asp Thr Arg Leu Leu Ala Lys Phe Asp Leu Ser 
    370                 375                 380                 


Leu Ala Ala Lys His Met Ser Asn Thr Tyr Leu Ser Gly Ile Ala Gln 
385                 390                 395                 400 


Tyr Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr 
                405                 410                 415     


Gly Ser Thr Asp Ser Lys Ala Arg Tyr Met Val Ala Tyr Ile Pro Pro 
            420                 425                 430         


Gly Val Glu Thr Pro Pro Asp Thr Pro Glu Arg Ala Ala His Cys Ile 
        435                 440                 445             


His Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile 
    450                 455                 460                 


Pro Tyr Val Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala 
465                 470                 475                 480 


Glu Thr Ile Asn Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His 
                485                 490                 495     


Gly Lys Ala Glu Asn Asp Thr Leu Val Val Ser Val Ser Ala Gly Lys 
            500                 505                 510         


Asp Phe Glu Leu Arg Leu Pro Ile Asp Pro Arg Gln Gln Thr Thr Ala 
        515                 520                 525             


Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly 
    530                 535                 540                 


Gly Glu Thr Gln Ile Gln Arg Arg His His Thr Asp Ile Gly Phe Ile 
545                 550                 555                 560 


Met Asp Arg Phe Val Lys Ile Gln Ser Leu Ser Pro Thr His Val Ile 
                565                 570                 575     


Asp Leu Met Gln Ala His Gln His Gly Leu Val Gly Ala Leu Leu Arg 
            580                 585                 590         


Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile Val Val Arg His Glu 
        595                 600                 605             


Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Ser Ala Leu Leu 
    610                 615                 620                 


Asn Thr Ser Asn Pro Thr Ala Tyr Asn Lys Ala Pro Phe Thr Arg Leu 
625                 630                 635                 640 


Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn 
                645                 650                 655     


Gly Thr Ser Lys Tyr Ala Val Gly Gly Ser Gly Arg Arg Gly Asp Met 
            660                 665                 670         


Gly Ser Leu Ala Ala Arg Val Val Lys Gln Leu Pro Ala Ser Phe Asn 
        675                 680                 685             


Tyr Gly Ala Ile Lys Ala Asp Ala Ile His Glu Leu Leu Val Arg Met 
    690                 695                 700                 


Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Leu Leu Ala Ile Glu Val 
705                 710                 715                 720 


Ser Ser Gln Asp Arg His Lys Gln Lys Ile Ile Ala Pro Ala Lys Gln 
                725                 730                 735     


Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
            740                 745                 750         


Pro Gly Pro Phe Phe Phe Ala Asp Val Arg Ser Asn Phe Ser Lys Leu 
        755                 760                 765             


Val Asp Thr Ile Asn Gln Met Gln Glu Asp Met Ser Thr Lys His Gly 
    770                 775                 780                 


Pro Asp Phe Asn Arg Leu Val Ser Ala Phe Glu Glu Leu Ala Thr Gly 
785                 790                 795                 800 


Val Lys Ala Ile Arg Thr Gly Leu Asp Glu Ala Lys Pro Trp Tyr Lys 
                805                 810                 815     


Leu Ile Lys Leu Leu Ser Arg Leu Ser Cys Met Ala Ala Val Ala Ala 
            820                 825                 830         


Arg Ser Lys Asp Pro Val Leu Val Ala Ile Met Leu Ala Asp Thr Gly 
        835                 840                 845             


Leu Glu Arg Gln Arg Pro Leu Lys Val Arg Ala Lys Leu Pro Gln Gln 
    850                 855                 860                 


Glu Gly Pro Tyr Ala Gly Pro Leu Glu Arg Gln Lys Pro Leu Lys Val 
865                 870                 875                 880 


Lys Ala Lys Ala Pro Val Val Lys Glu Gly Pro Tyr Glu Gly Pro Val 
                885                 890                 895     


Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Leu Ile Val Thr 
            900                 905                 910         


Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met Val Met Gly Asn 
        915                 920                 925             


Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr Val Ala Ile Cys 
    930                 935                 940                 


Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val Pro Arg His Leu 
945                 950                 955                 960 


Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly Arg Ala Met Thr 
                965                 970                 975     


Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys Val Lys Gly Gln 
            980                 985                 990         


Asp Met Leu Ser Asp Ala Ala Leu  Met Val Leu His Arg  Gly Asn Arg 
        995                 1000                 1005             


Val Arg  Asp Ile Thr Lys His  Phe Arg Asp Thr Ala  Arg Met Lys 
    1010                 1015                 1020             


Lys Gly  Thr Pro Val Val Gly  Val Val Asn Asn Ala  Asp Val Gly 
    1025                 1030                 1035             


Arg Leu  Ile Phe Ser Gly Glu  Ala Leu Thr Tyr Lys  Asp Ile Val 
    1040                 1045                 1050             


Val Cys  Met Asp Gly Asp Thr  Met Pro Gly Leu Phe  Ala Tyr Lys 
    1055                 1060                 1065             


Ala Ala  Thr Lys Ala Gly Tyr  Cys Gly Gly Ala Val  Leu Ala Lys 
    1070                 1075                 1080             


Asp Gly  Ala Asp Thr Phe Ile  Val Gly Thr His Ser  Ala Gly Gly 
    1085                 1090                 1095             


Asn Gly  Val Gly Tyr Cys Ser  Cys Val Ser Arg Ser  Met Leu Leu 
    1100                 1105                 1110             


Arg Met  Lys Ala His Val Asp  Pro Glu Pro Gln His  Glu 
    1115                 1120                 1125     


<210>  3
<211>  3378
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding modified polyprotein of A24

<400>  3
atgggtgctg gccagtcctc ccctgctacc ggttcccaga accagtccgg caacaccggt       60

tccatcatca acaactacta catgcagcag taccagaact ccatggacac ccagctggga      120

gacaacgcta tctccggtgg ttccaacgag ggttccaccg acaccacctc tacccacacc      180

accaacaccc agaacaacga ctggttctcc aagctggctt cctccgcttt caccggcctg      240

ttcggtgctc tgctggctga caagaaaacc gaggaaacca ccctgctcga ggaccgtatc      300

ctgaccaccc gtaacggtca caccacttcc accacccagt cctccgtggg cgtgacccac      360

ggttactcca ccgaagagga ccacgtggcc ggtcctaaca cctccggcct ggaaacccgt      420

gtggtgcagg ctgagcgctt ctacaagaag tacctgttcg actggaccac cgacaaggct      480

ttcggtcacc tggaaaagct ggaactgccc tccgaccacc acggcgtgtt cggatgcctg      540

gtggactcct acgcttacat gcgtaacggc tgggacgtgg aggtgtccgc tgtgggcaac      600

cagttcaacg gtggttgcct gctggtggct atggtgcccg agtggaagga atttgacacc      660

cgcgagaagt accagctgac cctgttcccc caccagttca tctccccccg taccaacatg      720

accgctcaca tcaccgtgcc ctacctgggc gtgaaccgtt acgaccagta caagaagcac      780

aagccctgga ccctggtggt catggtggtg tcccccctga ccgtgaacaa cacctccgct      840

gctcagatca aggtgtacgc taacatcgct cccacctacg tgcacgtcgc cggagagctg      900

ccctccaagg aaggcatctt ccccgtcgct tgcgctgacg gttacggtgg cctggtcacc      960

accgacccca agaccgctga ccccgcttac ggcaaggtgt acaacccccc tcgcaccaac     1020

taccccggtc gtttcaccaa cctgctggac gtggccgagg cttgccccac cttcctgtgc     1080

ttcgacgacg gcaagcccta cgtgaccacc aggaccgacg acacccgtct gctggctaag     1140

ttcgacctgt ccctggctgc taagcacatg tccaacacct acctgtccgg tatcgctcag     1200

tactacaccc agtactccgg caccatcaac ctgcacttca tgttcaccgg ctccaccgac     1260

tccaaggctc gttacatggt ggcttacatc ccccctggtg tcgagactcc ccccgacact     1320

cctgagcgtg ctgctcactg catccacgct gagtgggaca ccggcctgaa ctccaagttc     1380

accttctcca tcccttacgt gtccgctgct gactacgcgt acaccgcttc cgacaccgct     1440

gagactatca acgtgcaggg ctgggtctgc atctaccaga tcacccacgg caaggctgag     1500

aacgacaccc tggtcgtgtc cgtgtccgcc ggcaaggact tcgagctgcg tctgcccatc     1560

gaccctcgtc agcagaccac cgctaccggc gagtctgctg acccagtgac caccaccgtg     1620

gagaactacg gtggcgagac tcagatccag cgtcgtcacc acaccgacat cggtttcatc     1680

atggaccgct tcgtgaagat ccagtccctg tcccctaccc acgtgatcga cctgatgcag     1740

gctcaccagc acggactcgt gggtgctctc ctgcgtgctg ctacctacta cttctccgac     1800

ctggaaatcg tcgtgcgtca cgagggcaac ctgacctggg tgcccaacgg tgctcctgag     1860

tccgctctgc tgaacacctc caaccccacc gcttacaaca aggctccctt cacccgtctg     1920

gctctgcctt acaccgctcc ccaccgtgtg ctggctaccg tgtacaacgg cacctccaag     1980

tacgctgtgg gcggttccgg tcgtcgtggc gacatgggtt ccctggccgc tcgtgtggtc     2040

aagcagctgc ccgcttcctt caactacggt gctatcaagg ctgacgctat ccacgagctg     2100

ttggtgcgta tgaagcgtgc tgagctgtac tgcccccgtc ccctgctggc tatcgaggtg     2160

tcctcccagg accgtcacaa gcagaagatc atcgctcccg ctaagcagct gctgaacttc     2220

gacctgctga agctggctgg cgacgtcgag tccaaccccg gtcccttctt cttcgctgac     2280

gtgcgttcca acttctctaa gctggtggac actatcaacc agatgcaaga ggacatgtcc     2340

accaagcacg gtcccgactt caaccgtctg gtgtccgctt tcgaggaact ggctaccggc     2400

gtgaaggcta tccgtaccgg cctggacgag gctaagccct ggtacaagct gatcaagctg     2460

ctgtcccgtc tgtcctgcat ggctgctgtg gctgctcgtt ccaaggaccc cgtgctggtg     2520

gccatcatgc tggccgacac cggcttggag cgccagcgtc ccctgaaggt ccgcgctaag     2580

ctgccccagc aggaaggccc ttacgctggt cccctcgagc gtcagaagcc tctgaaggtc     2640

aaggctaagg ctcccgtggt caaggaagga ccctacgagg gacccgtgaa gaagcccgtc     2700

gctctcaagg ttaaggccaa gaacctgatc gtgaccgagt ccggtgctcc tcccaccgac     2760

ctgcaaaaga tggtcatggg caacaccaag cccgtggagc tgatcctgga cggcaagacc     2820

gtggctatct gctgcgctac cggtgttttc ggcaccgctt acctggtgcc ccgtcacctg     2880

ttcgctgaga agtacgacaa gatcatgctg gacggtcgtg ctatgaccga ctccgactac     2940

cgtgtgttcg agttcgagat caaggtcaag ggccaggaca tgctgtccga cgctgctctg     3000

atggtgctgc accgtggcaa ccgtgtgcgt gacatcacca agcacttccg tgacaccgct     3060

cgtatgaaga agggcacccc cgtcgtcggt gtcgtgaaca acgctgacgt gggtcgtctg     3120

atcttctccg gcgaggctct gacctacaag gacatcgtcg tgtgcatgga cggcgacacc     3180

atgcccggac tgttcgctta caaggctgct accaaggctg gttactgcgg tggtgctgtg     3240

ctggccaagg acggtgctga caccttcatc gtgggcaccc actccgctgg tggcaacggt     3300

gtcggttact gctcctgcgt gtcccgttcc atgctgctgc gcatgaaggc tcacgtggac     3360

cccgagcccc agcacgag                                                   3378


<210>  4
<211>  1126
<212>  PRT
<213>  artificial sequence

<220>
<223>  Unmodified Polyprotein of A24 Cruzeiro Strain

<400>  4

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Thr Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu 
                85                  90                  95      


Glu Asp Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr 
            100                 105                 110         


Gln Ser Ser Val Gly Val Thr His Gly Tyr Ser Thr Glu Glu Asp His 
        115                 120                 125             


Val Ala Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala 
    130                 135                 140                 


Glu Arg Phe Tyr Lys Lys Tyr Leu Phe Asp Trp Thr Thr Asp Lys Ala 
145                 150                 155                 160 


Phe Gly His Leu Glu Lys Leu Glu Leu Pro Ser Asp His His Gly Val 
                165                 170                 175     


Phe Gly His Leu Val Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp 
            180                 185                 190         


Val Glu Val Ser Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu 
        195                 200                 205             


Val Ala Met Val Pro Glu Trp Lys Glu Phe Asp Thr Arg Glu Lys Tyr 
    210                 215                 220                 


Gln Leu Thr Leu Phe Pro His Gln Phe Ile Ser Pro Arg Thr Asn Met 
225                 230                 235                 240 


Thr Ala His Ile Thr Val Pro Tyr Leu Gly Val Asn Arg Tyr Asp Gln 
                245                 250                 255     


Tyr Lys Lys His Lys Pro Trp Thr Leu Val Val Met Val Val Ser Pro 
            260                 265                 270         


Leu Thr Val Asn Asn Thr Ser Ala Ala Gln Ile Lys Val Tyr Ala Asn 
        275                 280                 285             


Ile Ala Pro Thr Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu 
    290                 295                 300                 


Gly Ile Phe Pro Val Ala Cys Ala Asp Gly Tyr Gly Gly Leu Val Thr 
305                 310                 315                 320 


Thr Asp Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val Tyr Asn Pro 
                325                 330                 335     


Pro Arg Thr Asn Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala 
            340                 345                 350         


Glu Ala Cys Pro Thr Phe Leu Cys Phe Asp Asp Gly Lys Pro Tyr Val 
        355                 360                 365             


Thr Thr Arg Thr Asp Asp Thr Arg Leu Leu Ala Lys Phe Asp Leu Ser 
    370                 375                 380                 


Leu Ala Ala Lys His Met Ser Asn Thr Tyr Leu Ser Gly Ile Ala Gln 
385                 390                 395                 400 


Tyr Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr 
                405                 410                 415     


Gly Ser Thr Asp Ser Lys Ala Arg Tyr Met Val Ala Tyr Ile Pro Pro 
            420                 425                 430         


Gly Val Glu Thr Pro Pro Asp Thr Pro Glu Arg Ala Ala His Cys Ile 
        435                 440                 445             


His Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile 
    450                 455                 460                 


Pro Tyr Val Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala 
465                 470                 475                 480 


Glu Thr Ile Asn Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His 
                485                 490                 495     


Gly Lys Ala Glu Asn Asp Thr Leu Val Val Ser Val Ser Ala Gly Lys 
            500                 505                 510         


Asp Phe Glu Leu Arg Leu Pro Ile Asp Pro Arg Gln Gln Thr Thr Ala 
        515                 520                 525             


Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly 
    530                 535                 540                 


Gly Glu Thr Gln Ile Gln Arg Arg His His Thr Asp Ile Gly Phe Ile 
545                 550                 555                 560 


Met Asp Arg Phe Val Lys Ile Gln Ser Leu Ser Pro Thr His Val Ile 
                565                 570                 575     


Asp Leu Met Gln Ala His Gln His Gly Leu Val Gly Ala Leu Leu Arg 
            580                 585                 590         


Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile Val Val Arg His Glu 
        595                 600                 605             


Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Ser Ala Leu Leu 
    610                 615                 620                 


Asn Thr Ser Asn Pro Thr Ala Tyr Asn Lys Ala Pro Phe Thr Arg Leu 
625                 630                 635                 640 


Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn 
                645                 650                 655     


Gly Thr Ser Lys Tyr Ala Val Gly Gly Ser Gly Arg Arg Gly Asp Met 
            660                 665                 670         


Gly Ser Leu Ala Ala Arg Val Val Lys Gln Leu Pro Ala Ser Phe Asn 
        675                 680                 685             


Tyr Gly Ala Ile Lys Ala Asp Ala Ile His Glu Leu Leu Val Arg Met 
    690                 695                 700                 


Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Leu Leu Ala Ile Glu Val 
705                 710                 715                 720 


Ser Ser Gln Asp Arg His Lys Gln Lys Ile Ile Ala Pro Ala Lys Gln 
                725                 730                 735     


Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
            740                 745                 750         


Pro Gly Pro Phe Phe Phe Ala Asp Val Arg Ser Asn Phe Ser Lys Leu 
        755                 760                 765             


Val Asp Thr Ile Asn Gln Met Gln Glu Asp Met Ser Thr Lys His Gly 
    770                 775                 780                 


Pro Asp Phe Asn Arg Leu Val Ser Ala Phe Glu Glu Leu Ala Thr Gly 
785                 790                 795                 800 


Val Lys Ala Ile Arg Thr Gly Leu Asp Glu Ala Lys Pro Trp Tyr Lys 
                805                 810                 815     


Leu Ile Lys Leu Leu Ser Arg Leu Ser Cys Met Ala Ala Val Ala Ala 
            820                 825                 830         


Arg Ser Lys Asp Pro Val Leu Val Ala Ile Met Leu Ala Asp Thr Gly 
        835                 840                 845             


Leu Glu Arg Gln Arg Pro Leu Lys Val Arg Ala Lys Leu Pro Gln Gln 
    850                 855                 860                 


Glu Gly Pro Tyr Ala Gly Pro Leu Glu Arg Gln Lys Pro Leu Lys Val 
865                 870                 875                 880 


Lys Ala Lys Ala Pro Val Val Lys Glu Gly Pro Tyr Glu Gly Pro Val 
                885                 890                 895     


Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Leu Ile Val Thr 
            900                 905                 910         


Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met Val Met Gly Asn 
        915                 920                 925             


Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr Val Ala Ile Cys 
    930                 935                 940                 


Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val Pro Arg His Leu 
945                 950                 955                 960 


Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly Arg Ala Met Thr 
                965                 970                 975     


Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys Val Lys Gly Gln 
            980                 985                 990         


Asp Met Leu Ser Asp Ala Ala Leu  Met Val Leu His Arg  Gly Asn Arg 
        995                 1000                 1005             


Val Arg  Asp Ile Thr Lys His  Phe Arg Asp Thr Ala  Arg Met Lys 
    1010                 1015                 1020             


Lys Gly  Thr Pro Val Val Gly  Val Val Asn Asn Ala  Asp Val Gly 
    1025                 1030                 1035             


Arg Leu  Ile Phe Ser Gly Glu  Ala Leu Thr Tyr Lys  Asp Ile Val 
    1040                 1045                 1050             


Val Cys  Met Asp Gly Asp Thr  Met Pro Gly Leu Phe  Ala Tyr Lys 
    1055                 1060                 1065             


Ala Ala  Thr Lys Ala Gly Tyr  Cys Gly Gly Ala Val  Leu Ala Lys 
    1070                 1075                 1080             


Asp Gly  Ala Asp Thr Phe Ile  Val Gly Thr His Ser  Ala Gly Gly 
    1085                 1090                 1095             


Asn Gly  Val Gly Tyr Cys Ser  Cys Val Ser Arg Ser  Met Leu Leu 
    1100                 1105                 1110             


Arg Met  Lys Ala His Val Asp  Pro Glu Pro Gln His  Glu 
    1115                 1120                 1125     


<210>  5
<211>  736
<212>  PRT
<213>  artificial sequence

<220>
<223>  Wild-type polyprotein of FMDV O1 manisa strain (GenBank AAT01766)

<400>  5

Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly 
1               5                   10                  15      


Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn 
            20                  25                  30          


Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Thr Ser Gly Gly Ser Asn 
        35                  40                  45              


Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln Asn 
    50                  55                  60                  


Asn Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Ser Gly Leu Phe 
65                  70                  75                  80  


Gly Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu 
                85                  90                  95      


Asp Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln 
            100                 105                 110         


Ser Ser Val Gly Val Thr Tyr Gly Tyr Ala Thr Ala Glu Asp Phe Val 
        115                 120                 125             


Ser Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Ala Gln Ala Glu 
    130                 135                 140                 


Arg Phe Phe Lys Thr His Leu Phe Asp Trp Val Thr Ser Asp Pro Phe 
145                 150                 155                 160 


Gly Arg Cys His Leu Leu Glu Leu Pro Thr Asp His Lys Gly Val Tyr 
                165                 170                 175     


Gly Ser Leu Thr Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val 
            180                 185                 190         


Glu Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val 
        195                 200                 205             


Ala Met Val Pro Glu Leu Cys Ser Ile Gln Lys Arg Glu Leu Tyr Gln 
    210                 215                 220                 


Leu Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr 
225                 230                 235                 240 


Ala His Ile Thr Val Pro Phe Val Gly Val Asn Arg Tyr Asp Gln Tyr 
                245                 250                 255     


Lys Val His Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu 
            260                 265                 270         


Thr Val Asn Ser Glu Gly Ala Pro Gln Ile Lys Val Tyr Ala Asn Ile 
        275                 280                 285             


Ala Pro Thr Asn Val His Val Ala Gly Glu Phe Pro Ser Lys Glu Gly 
    290                 295                 300                 


Ile Phe Pro Val Ala Cys Ser Asp Gly Tyr Gly Gly Leu Val Thr Thr 
305                 310                 315                 320 


Asp Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val Phe Asn Pro Pro 
                325                 330                 335     


Arg Asn Met Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val Ala Glu 
            340                 345                 350         


Ala Cys Pro Thr Phe Leu His Phe Glu Gly Asp Val Pro Tyr Val Thr 
        355                 360                 365             


Thr Lys Thr Asp Ser Asp Arg Val Leu Ala Gln Phe Asp Leu Ser Leu 
    370                 375                 380                 


Ala Ala Lys His Met Ser Asn Thr Phe Leu Ala Gly Leu Ala Gln Tyr 
385                 390                 395                 400 


Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr Gly 
                405                 410                 415     


Pro Thr Asp Ala Lys Ala Arg Tyr Met Ile Ala Tyr Ala Pro Pro Gly 
            420                 425                 430         


Met Glu Pro Pro Lys Thr Pro Glu Ala Ala Ala His Cys Ile His Ala 
        435                 440                 445             


Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr 
    450                 455                 460                 


Leu Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala Glu Thr 
465                 470                 475                 480 


Thr Asn Val Gln Gly Trp Val Cys Leu Phe Gln Ile Thr His Gly Lys 
                485                 490                 495     


Ala Asp Gly Asp Ala Leu Val Val Leu Ala Ser Ala Gly Lys Asp Phe 
            500                 505                 510         


Glu Leu Arg Leu Pro Val Asp Ala Arg Thr Gln Thr Thr Ser Ala Gly 
        515                 520                 525             


Glu Ser Ala Asp Pro Val Thr Ala Thr Val Glu Asn Tyr Gly Gly Glu 
    530                 535                 540                 


Thr Gln Val Gln Arg Arg Gln His Thr Asp Val Ser Phe Ile Leu Asp 
545                 550                 555                 560 


Arg Phe Val Lys Val Thr Pro Lys Asp Gln Ile Asn Val Leu Asp Leu 
                565                 570                 575     


Met Gln Thr Pro Ala His Thr Leu Val Gly Ala Leu Leu Arg Thr Ala 
            580                 585                 590         


Thr Tyr Tyr Phe Ala Asp Leu Glu Val Ala Val Lys His Glu Gly Asn 
        595                 600                 605             


Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Ala Ala Leu Asp Asn Thr 
    610                 615                 620                 


Thr Asn Pro Thr Ala Tyr His Lys Ala Pro Leu Thr Arg Leu Ala Leu 
625                 630                 635                 640 


Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Asn 
                645                 650                 655     


Ser Lys Tyr Gly Asp Gly Thr Val Ala Asn Val Arg Gly Asp Leu Gln 
            660                 665                 670         


Val Leu Ala Gln Lys Ala Ala Arg Ala Leu Pro Thr Ser Phe Asn Tyr 
        675                 680                 685             


Gly Ala Ile Lys Ala Thr Arg Val Thr Glu Leu Leu Tyr Arg Met Lys 
    690                 695                 700                 


Arg Ala Glu Thr Tyr Cys Pro Arg Pro Leu Leu Ala Ile His Pro Asp 
705                 710                 715                 720 


Gln Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Leu Leu 
                725                 730                 735     


<210>  6
<211>  737
<212>  PRT
<213>  artificial sequence

<220>
<223>  Modified polyprotein of FMDV O1 manisa strain in VP2 (S93C) or P1
       (S179C)

<400>  6

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Thr Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Ser Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu 
                85                  90                  95      


Glu Asp Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr 
            100                 105                 110         


Gln Ser Ser Val Gly Val Thr Tyr Gly Tyr Ala Thr Ala Glu Asp Phe 
        115                 120                 125             


Val Ser Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Ala Gln Ala 
    130                 135                 140                 


Glu Arg Phe Phe Lys Thr His Leu Phe Asp Trp Val Thr Ser Asp Pro 
145                 150                 155                 160 


Phe Gly Arg Cys His Leu Leu Glu Leu Pro Thr Asp His Lys Gly Val 
                165                 170                 175     


Tyr Gly Cys Leu Thr Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp 
            180                 185                 190         


Val Glu Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu 
        195                 200                 205             


Val Ala Met Val Pro Glu Leu Cys Ser Ile Gln Lys Arg Glu Leu Tyr 
    210                 215                 220                 


Gln Leu Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met 
225                 230                 235                 240 


Thr Ala His Ile Thr Val Pro Phe Val Gly Val Asn Arg Tyr Asp Gln 
                245                 250                 255     


Tyr Lys Val His Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro 
            260                 265                 270         


Leu Thr Val Asn Ser Glu Gly Ala Pro Gln Ile Lys Val Tyr Ala Asn 
        275                 280                 285             


Ile Ala Pro Thr Asn Val His Val Ala Gly Glu Phe Pro Ser Lys Glu 
    290                 295                 300                 


Gly Ile Phe Pro Val Ala Cys Ser Asp Gly Tyr Gly Gly Leu Val Thr 
305                 310                 315                 320 


Thr Asp Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val Phe Asn Pro 
                325                 330                 335     


Pro Arg Asn Met Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val Ala 
            340                 345                 350         


Glu Ala Cys Pro Thr Phe Leu His Phe Glu Gly Asp Val Pro Tyr Val 
        355                 360                 365             


Thr Thr Lys Thr Asp Ser Asp Arg Val Leu Ala Gln Phe Asp Leu Ser 
    370                 375                 380                 


Leu Ala Ala Lys His Met Ser Asn Thr Phe Leu Ala Gly Leu Ala Gln 
385                 390                 395                 400 


Tyr Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr 
                405                 410                 415     


Gly Pro Thr Asp Ala Lys Ala Arg Tyr Met Ile Ala Tyr Ala Pro Pro 
            420                 425                 430         


Gly Met Glu Pro Pro Lys Thr Pro Glu Ala Ala Ala His Cys Ile His 
        435                 440                 445             


Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro 
    450                 455                 460                 


Tyr Leu Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala Glu 
465                 470                 475                 480 


Thr Thr Asn Val Gln Gly Trp Val Cys Leu Phe Gln Ile Thr His Gly 
                485                 490                 495     


Lys Ala Asp Gly Asp Ala Leu Val Val Leu Ala Ser Ala Gly Lys Asp 
            500                 505                 510         


Phe Glu Leu Arg Leu Pro Val Asp Ala Arg Thr Gln Thr Thr Ser Ala 
        515                 520                 525             


Gly Glu Ser Ala Asp Pro Val Thr Ala Thr Val Glu Asn Tyr Gly Gly 
    530                 535                 540                 


Glu Thr Gln Val Gln Arg Arg Gln His Thr Asp Val Ser Phe Ile Leu 
545                 550                 555                 560 


Asp Arg Phe Val Lys Val Thr Pro Lys Asp Gln Ile Asn Val Leu Asp 
                565                 570                 575     


Leu Met Gln Thr Pro Ala His Thr Leu Val Gly Ala Leu Leu Arg Thr 
            580                 585                 590         


Ala Thr Tyr Tyr Phe Ala Asp Leu Glu Val Ala Val Lys His Glu Gly 
        595                 600                 605             


Asn Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Ala Ala Leu Asp Asn 
    610                 615                 620                 


Thr Thr Asn Pro Thr Ala Tyr His Lys Ala Pro Leu Thr Arg Leu Ala 
625                 630                 635                 640 


Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly 
                645                 650                 655     


Asn Ser Lys Tyr Gly Asp Gly Thr Val Ala Asn Val Arg Gly Asp Leu 
            660                 665                 670         


Gln Val Leu Ala Gln Lys Ala Ala Arg Ala Leu Pro Thr Ser Phe Asn 
        675                 680                 685             


Tyr Gly Ala Ile Lys Ala Thr Arg Val Thr Glu Leu Leu Tyr Arg Met 
    690                 695                 700                 


Lys Arg Ala Glu Thr Tyr Cys Pro Arg Pro Leu Leu Ala Ile His Pro 
705                 710                 715                 720 


Asp Gln Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Leu 
                725                 730                 735     


Leu 
    


<210>  7
<211>  2211
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding modified polyprotein of FMDV O1 manisa 
       strain

<400>  7
atgggtgctg gccagtcctc ccccgctacc ggttcccaga accagtccgg caacaccggt       60

tccatcatca acaactacta catgcagcag taccagaact ccatggacac ccagctgggc      120

gacaacgcta cctccggtgg ttccaacgag ggttccaccg acaccacctc tacccacacc      180

accaacaccc agaacaacga ctggttctcc aagctggctt cctccgcttt ctccggcctg      240

ttcggtgctc tgctggctga caagaagacc gaggaaacca ccctgctcga ggaccgtatc      300

ctgaccaccc gtaacggtca caccacctcc accacccagt cctccgtggg tgtcacctac      360

ggttacgcta ccgctgagga cttcgtgtcc ggtcccaaca cctccggcct ggaaacccgt      420

gtggctcagg ctgagcgctt cttcaagacc cacctgttcg actgggtcac ctccgacccc      480

ttcggtcgtt gccacctgtt ggagctgccc accgaccaca agggcgtgta cggttgcctg      540

accgactcct acgcttacat gcgtaacggc tgggacgtgg aagtgaccgc tgtgggcaac      600

cagttcaacg gtggttgcct gctggtggct atggtgcccg agctgtgctc catccagaag      660

cgcgagctgt accagctgac cctgttcccc caccagttca tcaacccccg taccaacatg      720

accgctcaca tcaccgtgcc cttcgtgggc gtgaaccgtt acgaccagta caaggtgcac      780

aagccctgga ccctggtcgt gatggtggtg gctcccctga ccgtgaactc cgagggtgct      840

ccccagatca aggtgtacgc taacatcgct cccaccaacg tgcacgtggc cggcgagttc      900

ccatccaagg aaggcatctt ccccgtcgct tgctccgacg gttacggtgg cctggtcacc      960

actgacccca agaccgctga ccccgcttac ggcaaggtgt tcaacccccc tcgtaacatg     1020

ctgcccggtc gtttcaccaa cttcttggac gtggccgagg cttgccccac cttcctgcac     1080

ttcgagggcg acgtgcccta cgtgaccacc aagactgact ccgaccgtgt gctggctcag     1140

ttcgacctgt ccctggctgc taagcacatg tccaacactt tcttggctgg cctggctcag     1200

tactacaccc agtactccgg caccatcaac ctgcacttca tgttcaccgg tcccaccgac     1260

gctaaggctc gttacatgat cgcttacgct ccccctggca tggaaccccc caagacccca     1320

gaggctgctg ctcactgcat ccacgctgag tgggacaccg gcctgaactc caagttcacc     1380

ttctccatcc cttacctgtc cgctgctgac tacgcctaca ccgcttccga caccgctgag     1440

actaccaacg tccagggctg ggtctgcctg ttccagatca cccacggcaa ggctgacggc     1500

gacgctctgg tggtgctggc ttccgctggc aaggacttcg agctgcgtct gcccgtggac     1560

gctcgtaccc agaccacctc cgctggcgag tctgctgacc ccgtgaccgc taccgtcgag     1620

aactacggtg gcgagactca ggtgcagcgt cgtcagcaca ccgacgtgtc cttcatcctg     1680

gaccgtttcg tgaaggtcac ccccaaggac cagatcaacg tgctggacct gatgcagacc     1740

cccgctcaca ccctcgtggg cgctctgctg cgtaccgcta cctactactt cgctgacctg     1800

gaagtggctg tgaagcacga gggcaacctg acctgggtgc ccaacggtgc tcccgaggct     1860

gctctggaca acaccactaa ccccaccgct taccacaagg ctcctctgac ccgtctggct     1920

ctgccttaca ctgctcccca ccgcgtgctg gctaccgtgt acaacggcaa ctctaagtac     1980

ggcgacggca ccgtggctaa cgtgcgtggc gatctgcagg tcctggctca gaaggctgct     2040

cgcgctctgc ccacctcctt caactacggt gctatcaagg ctacccgtgt gaccgagctg     2100

ctgtaccgta tgaagcgtgc tgagacttac tgcccccgtc ccctgctggc tatccaccct     2160

gaccaggctc gtcacaagca aaagatcgtg gctcccgtga agcagctgct g              2211


<210>  8
<211>  1126
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified polyprotein of FMDV Iraq strain

<400>  8

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Ser Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu 
                85                  90                  95      


Glu Asp Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr 
            100                 105                 110         


Gln Ser Ser Val Gly Val Thr Tyr Gly Tyr Ser Thr Gln Glu Asp His 
        115                 120                 125             


Val Ser Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala 
    130                 135                 140                 


Glu Arg Phe Phe Lys Lys His Leu Phe Asp Trp Thr Pro Asp Lys Ala 
145                 150                 155                 160 


Phe Gly His Leu Glu Lys Leu Glu Leu Pro Thr Asp His Lys Gly Val 
                165                 170                 175     


Tyr Gly Cys Leu Val Asp Ser Phe Ala Tyr Met Arg Asn Gly Trp Asp 
            180                 185                 190         


Val Glu Val Ser Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu 
        195                 200                 205             


Val Ala Met Val Pro Glu Trp Lys Glu Phe Thr Pro Arg Glu Lys Tyr 
    210                 215                 220                 


Gln Leu Thr Leu Phe Pro His Gln Phe Ile Ser Pro Arg Thr Asn Met 
225                 230                 235                 240 


Thr Ala His Ile Val Val Pro Tyr Leu Gly Val Asn Arg Tyr Asp Gln 
                245                 250                 255     


Tyr Lys Lys His Lys Pro Trp Thr Leu Val Val Met Val Val Ser Pro 
            260                 265                 270         


Leu Thr Thr Asn Thr Val Ser Ala Gly Gln Ile Lys Val Tyr Ala Asn 
        275                 280                 285             


Ile Ala Pro Thr His Val His Val Ala Gly Glu Leu Pro Ser Lys Glu 
    290                 295                 300                 


Gly Ile Val Pro Val Ala Cys Ser Asp Gly Tyr Gly Gly Leu Val Thr 
305                 310                 315                 320 


Thr Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Met Val Tyr Asn Pro 
                325                 330                 335     


Pro Arg Thr Asn Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala 
            340                 345                 350         


Glu Ala Cys Pro Thr Phe Leu Cys Phe Asp Glu Gly Lys Pro Tyr Val 
        355                 360                 365             


Val Thr Arg Thr Asp Glu Gln Arg Leu Leu Ala Lys Phe Asp Val Ser 
    370                 375                 380                 


Leu Ala Ala Lys His Met Ser Asn Thr Tyr Leu Ser Gly Ile Ala Gln 
385                 390                 395                 400 


Tyr Tyr Ala Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr 
                405                 410                 415     


Gly Ser Thr Asp Ser Lys Ala Arg Tyr Met Val Ala Tyr Val Pro Pro 
            420                 425                 430         


Gly Val Glu Thr Pro Pro Asp Thr Pro Glu Lys Ala Ala His Cys Ile 
        435                 440                 445             


His Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile 
    450                 455                 460                 


Pro Tyr Val Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Val Ala 
465                 470                 475                 480 


Glu Thr Thr Asn Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His 
                485                 490                 495     


Gly Lys Ala Glu Gln Asp Thr Leu Val Val Ser Val Ser Ala Gly Lys 
            500                 505                 510         


Asp Phe Glu Leu Arg Leu Pro Ile Asp Pro Arg Ser Gln Thr Thr Thr 
        515                 520                 525             


Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly 
    530                 535                 540                 


Gly Glu Thr Gln Val Gln Arg Arg Gln His Thr Asp Val Thr Phe Ile 
545                 550                 555                 560 


Met Asp Arg Phe Val Lys Ile Gln Asn Leu Asn Pro Thr His Val Ile 
                565                 570                 575     


Asp Leu Met Gln Thr His Gln His Gly Leu Val Gly Ala Leu Leu Arg 
            580                 585                 590         


Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile Val Val Arg His Asp 
        595                 600                 605             


Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Ala Ala Leu Ser 
    610                 615                 620                 


Asn Thr Gly Asn Pro Thr Ala Tyr Leu Lys Ala Pro Phe Thr Arg Leu 
625                 630                 635                 640 


Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn 
                645                 650                 655     


Gly Thr Ser Lys Tyr Ser Ala Gly Gly Thr Gly Arg Arg Gly Asp Leu 
            660                 665                 670         


Gly Pro Leu Ala Ala Arg Val Ala Ala Gln Leu Pro Ala Ser Phe Asn 
        675                 680                 685             


Phe Gly Ala Ile Gln Ala Thr Thr Ile His Glu Leu Leu Val Arg Met 
    690                 695                 700                 


Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Leu Leu Ala Val Glu Val 
705                 710                 715                 720 


Ser Ser Gln Asp Arg His Lys Gln Lys Ile Ile Ala Pro Ala Lys Gln 
                725                 730                 735     


Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
            740                 745                 750         


Pro Gly Pro Phe Phe Phe Ala Asp Val Arg Ser Asn Phe Ser Lys Leu 
        755                 760                 765             


Val Asp Thr Ile Asn Gln Met Gln Glu Asp Met Ser Thr Lys His Gly 
    770                 775                 780                 


Pro Asp Phe Asn Arg Leu Val Ser Ala Phe Glu Glu Leu Ala Thr Gly 
785                 790                 795                 800 


Val Lys Ala Ile Arg Thr Gly Leu Asp Glu Ala Lys Pro Trp Tyr Lys 
                805                 810                 815     


Leu Ile Lys Leu Leu Ser Arg Leu Ser Cys Met Ala Ala Val Ala Ala 
            820                 825                 830         


Arg Ser Lys Asp Pro Val Leu Val Ala Ile Met Leu Ala Asp Thr Gly 
        835                 840                 845             


Leu Glu Arg Gln Arg Pro Leu Lys Val Arg Ala Lys Leu Pro Gln Gln 
    850                 855                 860                 


Glu Gly Pro Tyr Ala Gly Pro Leu Glu Arg Gln Lys Pro Leu Lys Val 
865                 870                 875                 880 


Lys Ala Lys Ala Pro Val Val Lys Glu Gly Pro Tyr Glu Gly Pro Val 
                885                 890                 895     


Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Leu Ile Val Thr 
            900                 905                 910         


Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met Val Met Gly Asn 
        915                 920                 925             


Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr Val Ala Ile Cys 
    930                 935                 940                 


Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val Pro Arg His Leu 
945                 950                 955                 960 


Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly Arg Ala Met Thr 
                965                 970                 975     


Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys Val Lys Gly Gln 
            980                 985                 990         


Asp Met Leu Ser Asp Ala Ala Leu  Met Val Leu His Arg  Gly Asn Arg 
        995                 1000                 1005             


Val Arg  Asp Ile Thr Lys His  Phe Arg Asp Thr Ala  Arg Met Lys 
    1010                 1015                 1020             


Lys Gly  Thr Pro Val Val Gly  Val Val Asn Asn Ala  Asp Val Gly 
    1025                 1030                 1035             


Arg Leu  Ile Phe Ser Gly Glu  Ala Leu Thr Tyr Lys  Asp Ile Val 
    1040                 1045                 1050             


Val Cys  Met Asp Gly Asp Thr  Met Pro Gly Leu Phe  Ala Tyr Lys 
    1055                 1060                 1065             


Ala Ala  Thr Lys Ala Gly Tyr  Cys Gly Gly Ala Val  Leu Ala Lys 
    1070                 1075                 1080             


Asp Gly  Ala Asp Thr Phe Ile  Val Gly Thr His Ser  Ala Gly Gly 
    1085                 1090                 1095             


Asn Gly  Val Gly Tyr Cys Ser  Cys Val Ser Arg Ser  Met Leu Leu 
    1100                 1105                 1110             


Arg Met  Lys Ala His Val Asp  Pro Glu Pro Gln His  Glu 
    1115                 1120                 1125     


<210>  9
<211>  3378
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding modified polyprotein of FMDV Iraq strain

<400>  9
atgggtgctg gccagtcctc ccccgctacc ggttcccaga accagtccgg caacaccggt       60

tccatcatca acaactacta catgcagcag taccagaact ccatggacac ccaactcggc      120

gacaacgcta tctccggtgg ttccaacgag ggttccaccg acaccacctc tacccacacc      180

accaacaccc agaacaacga ctggttctcc aagctggctt cctccgcttt ctccggcctg      240

ttcggtgctc tgctggctga caagaagacc gaggaaacca ccctgctcga ggaccgtatc      300

ctgaccaccc gtaacggtca caccacctcc accacccagt cctccgtggg tgttacctac      360

ggttactcca cccaagagga ccacgtgtcc ggtcccaaca cctccggcct ggaaacccgt      420

gtggtgcagg ctgagcgctt cttcaagaag cacctgttcg actggacccc cgacaaggct      480

ttcggtcacc tcgagaagct cgagctgccc accgaccaca agggcgtgta cggttgcctg      540

gtggacagct tcgcttacat gcgtaacggc tgggacgtcg aggtgtccgc tgtgggcaac      600

cagttcaacg gtggttgcct gctggtggct atggtgcccg agtggaaaga attcacccct      660

cgcgagaagt accagctgac cctgttcccc caccagttca tctccccccg taccaacatg      720

accgctcaca tcgtggtgcc ctacctgggt gtcaaccgtt acgaccagta caagaagcac      780

aagccctgga ccctggtggt tatggtggtg tctcccctga ccactaacac cgtgtccgct      840

ggccagatca aggtgtacgc taacatcgct cccacccacg tgcacgtcgc gggcgagctg      900

ccttccaaag aaggcatcgt ccccgtcgct tgctccgacg gttacggtgg cctggtcacc      960

accgacccca agaccgctga ccccgtgtac ggcatggtgt acaacccccc tcgcaccaac     1020

taccccggtc gtttcaccaa cctgctggac gtggccgagg cttgccccac cttcctgtgc     1080

ttcgacgagg gcaagcccta cgtggtcacc cgtaccgacg agcagcgtct gctggctaag     1140

ttcgacgtgt ccctggctgc taagcacatg tccaacacct acctgtccgg tatcgctcag     1200

tactacgccc agtactccgg caccatcaac ctgcacttca tgttcaccgg ctccaccgat     1260

tccaaggctc gttacatggt ggcttacgtg ccccctggtg tcgagactcc ccccgacacc     1320

cctgagaagg ctgctcactg catccacgct gagtgggaca ccggcctgaa ctccaagttc     1380

accttctcca tcccttacgt gtccgccgct gactacgctt acaccgcttc cgacgtcgcc     1440

gagactacca acgtgcaggg ctgggtctgc atctaccaga tcacccacgg caaggctgag     1500

caggacaccc tggtcgtgtc cgtgtctgct ggcaaggact tcgaactccg tctgcccatc     1560

gacccccgtt cccagaccac caccaccggc gagtctgccg accctgtgac caccaccgtg     1620

gaaaactacg gtggcgagac tcaggtgcag cgtcgtcagc acaccgacgt gaccttcatc     1680

atggaccgtt tcgtgaagat ccagaacctg aaccctaccc acgtgatcga cctgatgcag     1740

actcaccagc acggcctcgt gggcgctctg ctgcgtgctg ctacctacta cttctccgac     1800

ctcgagatcg tcgtccgtca cgacggcaac ctgacctggg tgcccaacgg tgctcccgag     1860

gctgctctgt ctaacaccgg caaccccacc gcttacctga aggctccctt cacccgtctg     1920

gctctgccct acaccgctcc ccaccgtgtg ctggctaccg tgtacaacgg cacctccaag     1980

tactccgctg gtggcaccgg tcgtcgtggc gacttgggtc ctctggctgc tcgtgtggct     2040

gctcagctgc ccgcttcctt caacttcggt gctatccagg ctaccaccat ccacgaactc     2100

ctcgtgcgta tgaagcgtgc tgagctgtac tgcccccgtc ccctgctggc tgtggaagtg     2160

tcctcccagg accgtcacaa gcagaagatc atcgctcccg ctaagcagct gctgaacttc     2220

gacctgctga agctggctgg cgacgtggaa tccaaccccg gtcccttctt cttcgctgac     2280

gtgcgttcca acttctctaa gctggtggac actatcaacc agatgcaaga ggacatgtcc     2340

accaagcacg gtcccgactt caaccgtctg gtgtccgctt tcgaggaact ggctaccggt     2400

gtcaaggcta tccgtaccgg cctggacgag gctaagccct ggtacaagct gatcaagctg     2460

ctgtcccgtc tgtcctgcat ggctgctgtc gctgctcgtt ccaaggaccc cgtgctggtc     2520

gctatcatgc tggccgacac cggcttggag cgtcagcgtc ctctgaaagt ccgcgctaag     2580

ctgccccagc aagagggccc gtacgctggt cccctcgagc gtcagaagcc cctgaaggtt     2640

aaagccaagg ctcccgtggt caaagaaggc ccatacgagg gtcccgtgaa gaagcccgtc     2700

gctctcaagg tcaaggccaa gaacctgatc gtgaccgagt ccggtgctcc ccccaccgac     2760

ctgcaaaaga tggtcatggg caacaccaag cccgtcgagc tgatcctgga cggcaagacc     2820

gtggctatct gctgcgctac cggcgtgttc ggtactgctt acctggtgcc ccgtcacctg     2880

ttcgctgaga agtacgacaa gatcatgctg gacggtcgtg ctatgaccga ctccgactac     2940

cgtgtgttcg agttcgagat caaagtcaag ggccaggaca tgctgtccga cgctgctctg     3000

atggtgctgc accgtggcaa ccgtgtgcgt gacatcacca agcacttccg tgacaccgct     3060

cgtatgaaga agggcacccc cgtcgtcggt gtcgtgaaca acgctgacgt gggtcgtctg     3120

atcttctccg gcgaggctct gacctacaag gacatcgtcg tgtgcatgga tggcgacacc     3180

atgcctggcc tgttcgctta caaggctgct accaaggctg gttactgcgg tggtgctgtc     3240

ctggctaagg acggtgctga caccttcatc gtgggcaccc actccgctgg cggaaacggt     3300

gtcggttact gctcctgcgt gtcccgttcc atgctgctgc gcatgaaggc tcacgtggac     3360

cccgagcccc agcacgag                                                   3378


<210>  10
<211>  1122
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified polyprotein of FMDV Asia strain

<400>  10

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Arg Leu Ala Ser Ser Ala Phe Ser Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu 
                85                  90                  95      


Glu Asp Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr 
            100                 105                 110         


Gln Ser Ser Val Gly Val Thr Tyr Gly Tyr Ala Val Ala Glu Asp Ala 
        115                 120                 125             


Val Ser Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Gln Gln Ala 
    130                 135                 140                 


Glu Arg Phe Phe Lys Lys His Leu Phe Asp Trp Thr Pro Asn Leu Ala 
145                 150                 155                 160 


Phe Gly His Cys Tyr Tyr Leu Glu Leu Pro Thr Glu His Lys Gly Val 
                165                 170                 175     


Tyr Gly Cys Leu Met Gly Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp 
            180                 185                 190         


Ile Glu Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu 
        195                 200                 205             


Val Ala Leu Val Pro Glu Leu Lys Glu Leu Asp Thr Arg Gln Lys Tyr 
    210                 215                 220                 


Gln Leu Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met 
225                 230                 235                 240 


Thr Ala His Ile Asn Val Pro Tyr Val Gly Ile Asn Arg Tyr Asp Gln 
                245                 250                 255     


Tyr Ala Leu His Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro 
            260                 265                 270         


Leu Thr Val Lys Thr Gly Gly Ser Glu Gln Ile Lys Val Tyr Met Asn 
        275                 280                 285             


Ala Ala Pro Thr Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu 
    290                 295                 300                 


Gly Ile Val Pro Val Ala Cys Ala Asp Gly Tyr Gly Asn Met Val Thr 
305                 310                 315                 320 


Thr Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Phe Asn Pro 
                325                 330                 335     


Pro Arg Thr Asn Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val Ala 
            340                 345                 350         


Glu Ala Cys Pro Thr Phe Leu Arg Phe Gly Glu Val Pro Phe Val Lys 
        355                 360                 365             


Thr Val Asn Ser Gly Asp Arg Leu Leu Ala Lys Phe Asp Val Ser Leu 
    370                 375                 380                 


Ala Ala Gly His Met Ser Asn Thr Tyr Leu Ala Gly Leu Ala Gln Tyr 
385                 390                 395                 400 


Tyr Thr Gln Tyr Ser Gly Thr Met Asn Val His Phe Met Phe Thr Gly 
                405                 410                 415     


Pro Thr Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Val Pro Pro Gly 
            420                 425                 430         


Met Thr Pro Pro Thr Asp Pro Glu His Ala Ala His Cys Ile His Ser 
        435                 440                 445             


Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr 
    450                 455                 460                 


Leu Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Val Ala Glu Thr 
465                 470                 475                 480 


Thr Ser Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His Gly Lys 
                485                 490                 495     


Ala Glu Gly Asp Ala Leu Val Val Ser Val Ser Ala Gly Lys Asp Phe 
            500                 505                 510         


Glu Phe Arg Leu Pro Val Asp Ala Arg Gln Gln Thr Thr Thr Thr Gly 
        515                 520                 525             


Glu Ser Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu 
    530                 535                 540                 


Thr Gln Thr Ala Arg Arg Leu His Thr Asp Val Ala Phe Ile Leu Asp 
545                 550                 555                 560 


Arg Phe Val Lys Leu Thr Ala Pro Lys Asn Ile Gln Thr Leu Asp Leu 
                565                 570                 575     


Met Gln Ile Pro Ser His Thr Leu Val Gly Ala Leu Leu Arg Ser Ala 
            580                 585                 590         


Thr Tyr Tyr Phe Ser Asp Leu Glu Val Ala Leu Val His Thr Gly Pro 
        595                 600                 605             


Val Thr Trp Val Pro Asn Gly Ala Pro Lys Asp Ala Leu Asn Asn Gln 
    610                 615                 620                 


Thr Asn Pro Thr Ala Tyr Gln Lys Gln Pro Ile Thr Arg Leu Ala Leu 
625                 630                 635                 640 


Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Lys 
                645                 650                 655     


Thr Ala Tyr Gly Glu Thr Thr Ser Arg Arg Gly Asp Met Ala Ala Leu 
            660                 665                 670         


Ala Gln Arg Leu Ser Ala Arg Leu Pro Thr Ser Phe Asn Tyr Gly Ala 
        675                 680                 685             


Val Lys Ala Asp Thr Ile Thr Glu Leu Leu Ile Arg Met Lys Arg Ala 
    690                 695                 700                 


Glu Thr Tyr Cys Pro Arg Pro Leu Leu Ala Leu Asp Thr Thr Gln Asp 
705                 710                 715                 720 


Arg Arg Lys Gln Glu Ile Ile Ala Pro Glu Lys Gln Val Leu Asn Phe 
                725                 730                 735     


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Phe 
            740                 745                 750         


Phe Phe Ala Asp Val Arg Ser Asn Phe Ser Lys Leu Val Asp Thr Ile 
        755                 760                 765             


Asn Gln Met Gln Glu Asp Met Ser Thr Lys His Gly Pro Asp Phe Asn 
    770                 775                 780                 


Arg Leu Val Ser Ala Phe Glu Glu Leu Ala Thr Gly Val Lys Ala Ile 
785                 790                 795                 800 


Arg Thr Gly Leu Asp Glu Ala Lys Pro Trp Tyr Lys Leu Ile Lys Leu 
                805                 810                 815     


Leu Ser Arg Leu Ser Cys Met Ala Ala Val Ala Ala Arg Ser Lys Asp 
            820                 825                 830         


Pro Val Leu Val Ala Ile Met Leu Ala Asp Thr Gly Leu Glu Arg Gln 
        835                 840                 845             


Arg Pro Leu Lys Val Arg Ala Lys Leu Pro Gln Gln Glu Gly Pro Tyr 
    850                 855                 860                 


Ala Gly Pro Leu Glu Arg Gln Lys Pro Leu Lys Val Lys Ala Lys Ala 
865                 870                 875                 880 


Pro Val Val Lys Glu Gly Pro Tyr Glu Gly Pro Val Lys Lys Pro Val 
                885                 890                 895     


Ala Leu Lys Val Lys Ala Lys Asn Leu Ile Val Thr Glu Ser Gly Ala 
            900                 905                 910         


Pro Pro Thr Asp Leu Gln Lys Met Val Met Gly Asn Thr Lys Pro Val 
        915                 920                 925             


Glu Leu Ile Leu Asp Gly Lys Thr Val Ala Ile Cys Cys Ala Thr Gly 
    930                 935                 940                 


Val Phe Gly Thr Ala Tyr Leu Val Pro Arg His Leu Phe Ala Glu Lys 
945                 950                 955                 960 


Tyr Asp Lys Ile Met Leu Asp Gly Arg Ala Met Thr Asp Ser Asp Tyr 
                965                 970                 975     


Arg Val Phe Glu Phe Glu Ile Lys Val Lys Gly Gln Asp Met Leu Ser 
            980                 985                 990         


Asp Ala Ala Leu Met Val Leu His  Arg Gly Asn Arg Val  Arg Asp Ile 
        995                 1000                 1005             


Thr Lys  His Phe Arg Asp Thr  Ala Arg Met Lys Lys  Gly Thr Pro 
    1010                 1015                 1020             


Val Val  Gly Val Val Asn Asn  Ala Asp Val Gly Arg  Leu Ile Phe 
    1025                 1030                 1035             


Ser Gly  Glu Ala Leu Thr Tyr  Lys Asp Ile Val Val  Cys Met Asp 
    1040                 1045                 1050             


Gly Asp  Thr Met Pro Gly Leu  Phe Ala Tyr Lys Ala  Ala Thr Lys 
    1055                 1060                 1065             


Ala Gly  Tyr Cys Gly Gly Ala  Val Leu Ala Lys Asp  Gly Ala Asp 
    1070                 1075                 1080             


Thr Phe  Ile Val Gly Thr His  Ser Ala Gly Gly Asn  Gly Val Gly 
    1085                 1090                 1095             


Tyr Cys  Ser Cys Val Ser Arg  Ser Met Leu Leu Arg  Met Lys Ala 
    1100                 1105                 1110             


His Val  Asp Pro Glu Pro Gln  His Glu 
    1115                 1120         


<210>  11
<211>  3366
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding modified protein of FMDV Asia strain

<400>  11
atgggtgctg gccagtcctc ccctgctacc ggttcccaga accagtccgg caacaccggt       60

tccatcatca acaactacta catgcagcag taccagaact ccatggacac ccagctcggc      120

gacaacgcta tctccggtgg ttccaacgag ggttccaccg acaccacctc cacccacacc      180

aacaacaccc agaacaacga ctggttctcc cgtctggctt cctccgcttt ctccggcctg      240

ttcggtgctc tgctggctga caagaagacc gaggaaacca ccctgctcga ggaccgtatc      300

ctgaccaccc gtaacggtca caccacctct accacccagt cctctgtggg tgtcacctac      360

ggttacgctg tggctgagga cgctgtgtcc ggtcccaaca cctccggcct ggaaacccgt      420

gtgcagcagg ctgagcgctt cttcaagaag cacctgttcg actggacccc caacctggct      480

ttcggtcact gctactacct cgagctgccc accgagcaca agggcgtgta cggttgcctg      540

atgggctcct acgcttacat gcgtaacggc tgggacatcg aagtgaccgc tgtgggcaac      600

cagttcaacg gtggttgcct gctggtggct ctggtgcccg agctgaaaga actggacacc      660

cgtcagaagt accagctgac cctgttcccc caccagttca tcaacccccg taccaacatg      720

accgctcaca tcaacgtgcc ctacgtgggt atcaaccgtt acgaccagta cgctctgcac      780

aagccctgga ccctggtcgt gatggtggtg gctcccctga ccgtcaagac cggtggctcc      840

gagcagatca aggtgtacat gaacgctgct cccacctacg tgcacgtggc cggcgagctg      900

ccctccaaag aaggcatcgt ccccgtcgct tgcgctgacg gttacggcaa catggtcacc      960

accgacccca agaccgctga ccccgtgtac ggcaaggtgt tcaacccccc tcgtaccaac     1020

ctgcccggtc gttttaccaa cttcctcgac gtggccgagg cttgccccac cttcctgcgt     1080

ttcggcgagg tccccttcgt caagactgtg aactccggcg accgtctgct ggctaagttc     1140

gacgtgtccc tggctgctgg tcacatgtcc aacacctacc tggctggcct ggctcagtac     1200

tacacccagt actccggcac catgaacgtc cacttcatgt tcaccggtcc caccgacgct     1260

aaggctcgtt acatggtggc ttacgtgccc cctggcatga ccccccctac cgaccctgaa     1320

cacgctgctc actgcatcca ctccgagtgg gacaccggcc tgaactccaa gttcaccttc     1380

tccatccctt acctgtccgc tgctgactac gcctacaccg cttccgatgt cgccgagact     1440

acctccgtgc agggctgggt ttgcatctac cagatcaccc acggcaaggc tgagggcgac     1500

gctctggtgg tgtccgtgtc cgctggcaag gacttcgagt tccgtctgcc cgtggacgct     1560

cgtcagcaga ccaccaccac cggcgagtcc gctgacccag tgaccaccac cgtggaaaac     1620

tacggtggcg agactcagac cgctcgtcgc ctgcacaccg acgtggcctt catcctggac     1680

cgtttcgtga agctgaccgc tcccaagaac atccagaccc tggacctgat gcagatcccc     1740

tcccacaccc tcgtgggcgc tctgctgcgt tccgctacct actacttctc cgacctggaa     1800

gtcgctctgg tccacaccgg tcccgtgacc tgggtgccca acggtgctcc caaggacgct     1860

ctgaacaacc agaccaaccc caccgcttac cagaagcagc ccatcacccg cctggctctg     1920

ccttacaccg ctccccaccg tgtcctggct actgtgtaca acggcaagac cgcttacggc     1980

gaaaccacct cccgtcgtgg cgacatggct gctctggctc agcgtctgtc cgctcgtctg     2040

cccacctcct tcaactacgg tgctgtgaag gctgacacca tcaccgagct gctgatccgt     2100

atgaagcgtg ctgagactta ctgcccccgt cccctgctgg ctctggacac cacccaggac     2160

cgtcgcaagc aagagatcat cgctcccgag aagcaggtcc tgaacttcga cctgctgaag     2220

ctggctggcg acgtcgagtc caaccccggt cccttcttct tcgctgacgt gcgttccaac     2280

ttctccaagc tggtggacac catcaaccag atgcaagagg acatgtccac caagcacggt     2340

cccgacttca accgtctggt gtccgctttc gaggaactgg ctaccggtgt caaggctatc     2400

cgtaccggcc tggacgaggc taagccctgg tacaagctga tcaagctgct gtcccgtctg     2460

tcctgcatgg ctgctgtcgc tgctcgttcc aaggaccccg tgctggtcgc tatcatgctg     2520

gccgacaccg gcttggagcg ccagcgtcct ctgaaggttc gcgctaagct gcctcagcaa     2580

gagggacctt acgctggtcc cctcgagcgt cagaagcccc tgaaggtcaa ggctaaggct     2640

cccgtggtca aagaaggccc ctacgagggt cccgtgaaga agcccgtcgc tctcaaggtc     2700

aaggccaaga acctgatcgt gaccgagtcc ggtgctcccc ccaccgacct gcaaaagatg     2760

gtcatgggca acaccaagcc cgtcgagctg atcctggacg gaaagaccgt ggctatctgc     2820

tgcgctaccg gcgtgttcgg aaccgcttac ctggtgcccc gtcacctgtt cgctgagaag     2880

tacgacaaga tcatgctgga cggtcgtgct atgaccgact ccgactaccg tgtgttcgag     2940

ttcgagatca aggtcaaggg ccaggacatg ctctccgacg ctgctctgat ggtgctgcac     3000

cgtggcaacc gtgtgcgtga catcaccaag cacttccgtg acaccgctcg tatgaagaag     3060

ggcacccccg tcgtcggtgt cgtgaacaac gctgacgtgg gtcgtctgat cttctccggc     3120

gaggctctga cctacaagga catcgtcgtg tgcatggacg gcgataccat gcctggcctg     3180

ttcgcttaca aggctgctac caaggctggt tactgcggtg gtgctgtgct ggccaaggac     3240

ggtgctgaca ccttcatcgt gggcacccac tccgctggtg gcaacggtgt cggttactgc     3300

tcctgcgtgt cccgttccat gctgctgcgt atgaaggctc acgtggaccc cgagccccag     3360

cacgag                                                                3366


<210>  12
<211>  1126
<212>  PRT
<213>  artificial sequence

<220>
<223>  Wild-type polyprotein of FMDV Iraq strain

<400>  12

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Ser Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu 
                85                  90                  95      


Glu Asp Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr 
            100                 105                 110         


Gln Ser Ser Val Gly Val Thr Tyr Gly Tyr Ser Thr Gln Glu Asp His 
        115                 120                 125             


Val Ser Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala 
    130                 135                 140                 


Glu Arg Phe Phe Lys Lys His Leu Phe Asp Trp Thr Pro Asp Lys Ala 
145                 150                 155                 160 


Phe Gly His Leu Glu Lys Leu Glu Leu Pro Thr Asp His Lys Gly Val 
                165                 170                 175     


Tyr Gly His Leu Val Asp Ser Phe Ala Tyr Met Arg Asn Gly Trp Asp 
            180                 185                 190         


Val Glu Val Ser Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu 
        195                 200                 205             


Val Ala Met Val Pro Glu Trp Lys Glu Phe Thr Pro Arg Glu Lys Tyr 
    210                 215                 220                 


Gln Leu Thr Leu Phe Pro His Gln Phe Ile Ser Pro Arg Thr Asn Met 
225                 230                 235                 240 


Thr Ala His Ile Val Val Pro Tyr Leu Gly Val Asn Arg Tyr Asp Gln 
                245                 250                 255     


Tyr Lys Lys His Lys Pro Trp Thr Leu Val Val Met Val Val Ser Pro 
            260                 265                 270         


Leu Thr Thr Asn Thr Val Ser Ala Gly Gln Ile Lys Val Tyr Ala Asn 
        275                 280                 285             


Ile Ala Pro Thr His Val His Val Ala Gly Glu Leu Pro Ser Lys Glu 
    290                 295                 300                 


Gly Ile Val Pro Val Ala Cys Ser Asp Gly Tyr Gly Gly Leu Val Thr 
305                 310                 315                 320 


Thr Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Met Val Tyr Asn Pro 
                325                 330                 335     


Pro Arg Thr Asn Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala 
            340                 345                 350         


Glu Ala Cys Pro Thr Phe Leu Cys Phe Asp Glu Gly Lys Pro Tyr Val 
        355                 360                 365             


Val Thr Arg Thr Asp Glu Gln Arg Leu Leu Ala Lys Phe Asp Val Ser 
    370                 375                 380                 


Leu Ala Ala Lys His Met Ser Asn Thr Tyr Leu Ser Gly Ile Ala Gln 
385                 390                 395                 400 


Tyr Tyr Ala Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr 
                405                 410                 415     


Gly Ser Thr Asp Ser Lys Ala Arg Tyr Met Val Ala Tyr Val Pro Pro 
            420                 425                 430         


Gly Val Glu Thr Pro Pro Asp Thr Pro Glu Lys Ala Ala His Cys Ile 
        435                 440                 445             


His Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile 
    450                 455                 460                 


Pro Tyr Val Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Val Ala 
465                 470                 475                 480 


Glu Thr Thr Asn Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His 
                485                 490                 495     


Gly Lys Ala Glu Gln Asp Thr Leu Val Val Ser Val Ser Ala Gly Lys 
            500                 505                 510         


Asp Phe Glu Leu Arg Leu Pro Ile Asp Pro Arg Ser Gln Thr Thr Thr 
        515                 520                 525             


Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly 
    530                 535                 540                 


Gly Glu Thr Gln Val Gln Arg Arg Gln His Thr Asp Val Thr Phe Ile 
545                 550                 555                 560 


Met Asp Arg Phe Val Lys Ile Gln Asn Leu Asn Pro Thr His Val Ile 
                565                 570                 575     


Asp Leu Met Gln Thr His Gln His Gly Leu Val Gly Ala Leu Leu Arg 
            580                 585                 590         


Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile Val Val Arg His Asp 
        595                 600                 605             


Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Ala Ala Leu Ser 
    610                 615                 620                 


Asn Thr Gly Asn Pro Thr Ala Tyr Leu Lys Ala Pro Phe Thr Arg Leu 
625                 630                 635                 640 


Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn 
                645                 650                 655     


Gly Thr Ser Lys Tyr Ser Ala Gly Gly Thr Gly Arg Arg Gly Asp Leu 
            660                 665                 670         


Gly Pro Leu Ala Ala Arg Val Ala Ala Gln Leu Pro Ala Ser Phe Asn 
        675                 680                 685             


Phe Gly Ala Ile Gln Ala Thr Thr Ile His Glu Leu Leu Val Arg Met 
    690                 695                 700                 


Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Leu Leu Ala Val Glu Val 
705                 710                 715                 720 


Ser Ser Gln Asp Arg His Lys Gln Lys Ile Ile Ala Pro Ala Lys Gln 
                725                 730                 735     


Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
            740                 745                 750         


Pro Gly Pro Phe Phe Phe Ala Asp Val Arg Ser Asn Phe Ser Lys Leu 
        755                 760                 765             


Val Asp Thr Ile Asn Gln Met Gln Glu Asp Met Ser Thr Lys His Gly 
    770                 775                 780                 


Pro Asp Phe Asn Arg Leu Val Ser Ala Phe Glu Glu Leu Ala Thr Gly 
785                 790                 795                 800 


Val Lys Ala Ile Arg Thr Gly Leu Asp Glu Ala Lys Pro Trp Tyr Lys 
                805                 810                 815     


Leu Ile Lys Leu Leu Ser Arg Leu Ser Cys Met Ala Ala Val Ala Ala 
            820                 825                 830         


Arg Ser Lys Asp Pro Val Leu Val Ala Ile Met Leu Ala Asp Thr Gly 
        835                 840                 845             


Leu Glu Arg Gln Arg Pro Leu Lys Val Arg Ala Lys Leu Pro Gln Gln 
    850                 855                 860                 


Glu Gly Pro Tyr Ala Gly Pro Leu Glu Arg Gln Lys Pro Leu Lys Val 
865                 870                 875                 880 


Lys Ala Lys Ala Pro Val Val Lys Glu Gly Pro Tyr Glu Gly Pro Val 
                885                 890                 895     


Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Leu Ile Val Thr 
            900                 905                 910         


Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met Val Met Gly Asn 
        915                 920                 925             


Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr Val Ala Ile Cys 
    930                 935                 940                 


Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val Pro Arg His Leu 
945                 950                 955                 960 


Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly Arg Ala Met Thr 
                965                 970                 975     


Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys Val Lys Gly Gln 
            980                 985                 990         


Asp Met Leu Ser Asp Ala Ala Leu  Met Val Leu His Arg  Gly Asn Arg 
        995                 1000                 1005             


Val Arg  Asp Ile Thr Lys His  Phe Arg Asp Thr Ala  Arg Met Lys 
    1010                 1015                 1020             


Lys Gly  Thr Pro Val Val Gly  Val Val Asn Asn Ala  Asp Val Gly 
    1025                 1030                 1035             


Arg Leu  Ile Phe Ser Gly Glu  Ala Leu Thr Tyr Lys  Asp Ile Val 
    1040                 1045                 1050             


Val Cys  Met Asp Gly Asp Thr  Met Pro Gly Leu Phe  Ala Tyr Lys 
    1055                 1060                 1065             


Ala Ala  Thr Lys Ala Gly Tyr  Cys Gly Gly Ala Val  Leu Ala Lys 
    1070                 1075                 1080             


Asp Gly  Ala Asp Thr Phe Ile  Val Gly Thr His Ser  Ala Gly Gly 
    1085                 1090                 1095             


Asn Gly  Val Gly Tyr Cys Ser  Cys Val Ser Arg Ser  Met Leu Leu 
    1100                 1105                 1110             


Arg Met  Lys Ala His Val Asp  Pro Glu Pro Gln His  Glu 
    1115                 1120                 1125     


<210>  13
<211>  1122
<212>  PRT
<213>  artificial sequence

<220>
<223>  Wild-type polyprotein of FMDV Asia strain

<400>  13

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Arg Leu Ala Ser Ser Ala Phe Ser Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu 
                85                  90                  95      


Glu Asp Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr 
            100                 105                 110         


Gln Ser Ser Val Gly Val Thr Tyr Gly Tyr Ala Val Ala Glu Asp Ala 
        115                 120                 125             


Val Ser Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Gln Gln Ala 
    130                 135                 140                 


Glu Arg Phe Phe Lys Lys His Leu Phe Asp Trp Thr Pro Asn Leu Ala 
145                 150                 155                 160 


Phe Gly His Cys Tyr Tyr Leu Glu Leu Pro Thr Glu His Lys Gly Val 
                165                 170                 175     


Tyr Gly Ser Leu Met Gly Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp 
            180                 185                 190         


Ile Glu Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu 
        195                 200                 205             


Val Ala Leu Val Pro Glu Leu Lys Glu Leu Asp Thr Arg Gln Lys Tyr 
    210                 215                 220                 


Gln Leu Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met 
225                 230                 235                 240 


Thr Ala His Ile Asn Val Pro Tyr Val Gly Ile Asn Arg Tyr Asp Gln 
                245                 250                 255     


Tyr Ala Leu His Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro 
            260                 265                 270         


Leu Thr Val Lys Thr Gly Gly Ser Glu Gln Ile Lys Val Tyr Met Asn 
        275                 280                 285             


Ala Ala Pro Thr Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu 
    290                 295                 300                 


Gly Ile Val Pro Val Ala Cys Ala Asp Gly Tyr Gly Asn Met Val Thr 
305                 310                 315                 320 


Thr Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Phe Asn Pro 
                325                 330                 335     


Pro Arg Thr Asn Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val Ala 
            340                 345                 350         


Glu Ala Cys Pro Thr Phe Leu Arg Phe Gly Glu Val Pro Phe Val Lys 
        355                 360                 365             


Thr Val Asn Ser Gly Asp Arg Leu Leu Ala Lys Phe Asp Val Ser Leu 
    370                 375                 380                 


Ala Ala Gly His Met Ser Asn Thr Tyr Leu Ala Gly Leu Ala Gln Tyr 
385                 390                 395                 400 


Tyr Thr Gln Tyr Ser Gly Thr Met Asn Val His Phe Met Phe Thr Gly 
                405                 410                 415     


Pro Thr Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Val Pro Pro Gly 
            420                 425                 430         


Met Thr Pro Pro Thr Asp Pro Glu His Ala Ala His Cys Ile His Ser 
        435                 440                 445             


Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr 
    450                 455                 460                 


Leu Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Val Ala Glu Thr 
465                 470                 475                 480 


Thr Ser Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His Gly Lys 
                485                 490                 495     


Ala Glu Gly Asp Ala Leu Val Val Ser Val Ser Ala Gly Lys Asp Phe 
            500                 505                 510         


Glu Phe Arg Leu Pro Val Asp Ala Arg Gln Gln Thr Thr Thr Thr Gly 
        515                 520                 525             


Glu Ser Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu 
    530                 535                 540                 


Thr Gln Thr Ala Arg Arg Leu His Thr Asp Val Ala Phe Ile Leu Asp 
545                 550                 555                 560 


Arg Phe Val Lys Leu Thr Ala Pro Lys Asn Ile Gln Thr Leu Asp Leu 
                565                 570                 575     


Met Gln Ile Pro Ser His Thr Leu Val Gly Ala Leu Leu Arg Ser Ala 
            580                 585                 590         


Thr Tyr Tyr Phe Ser Asp Leu Glu Val Ala Leu Val His Thr Gly Pro 
        595                 600                 605             


Val Thr Trp Val Pro Asn Gly Ala Pro Lys Asp Ala Leu Asn Asn Gln 
    610                 615                 620                 


Thr Asn Pro Thr Ala Tyr Gln Lys Gln Pro Ile Thr Arg Leu Ala Leu 
625                 630                 635                 640 


Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Lys 
                645                 650                 655     


Thr Ala Tyr Gly Glu Thr Thr Ser Arg Arg Gly Asp Met Ala Ala Leu 
            660                 665                 670         


Ala Gln Arg Leu Ser Ala Arg Leu Pro Thr Ser Phe Asn Tyr Gly Ala 
        675                 680                 685             


Val Lys Ala Asp Thr Ile Thr Glu Leu Leu Ile Arg Met Lys Arg Ala 
    690                 695                 700                 


Glu Thr Tyr Cys Pro Arg Pro Leu Leu Ala Leu Asp Thr Thr Gln Asp 
705                 710                 715                 720 


Arg Arg Lys Gln Glu Ile Ile Ala Pro Glu Lys Gln Val Leu Asn Phe 
                725                 730                 735     


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Phe 
            740                 745                 750         


Phe Phe Ala Asp Val Arg Ser Asn Phe Ser Lys Leu Val Asp Thr Ile 
        755                 760                 765             


Asn Gln Met Gln Glu Asp Met Ser Thr Lys His Gly Pro Asp Phe Asn 
    770                 775                 780                 


Arg Leu Val Ser Ala Phe Glu Glu Leu Ala Thr Gly Val Lys Ala Ile 
785                 790                 795                 800 


Arg Thr Gly Leu Asp Glu Ala Lys Pro Trp Tyr Lys Leu Ile Lys Leu 
                805                 810                 815     


Leu Ser Arg Leu Ser Cys Met Ala Ala Val Ala Ala Arg Ser Lys Asp 
            820                 825                 830         


Pro Val Leu Val Ala Ile Met Leu Ala Asp Thr Gly Leu Glu Arg Gln 
        835                 840                 845             


Arg Pro Leu Lys Val Arg Ala Lys Leu Pro Gln Gln Glu Gly Pro Tyr 
    850                 855                 860                 


Ala Gly Pro Leu Glu Arg Gln Lys Pro Leu Lys Val Lys Ala Lys Ala 
865                 870                 875                 880 


Pro Val Val Lys Glu Gly Pro Tyr Glu Gly Pro Val Lys Lys Pro Val 
                885                 890                 895     


Ala Leu Lys Val Lys Ala Lys Asn Leu Ile Val Thr Glu Ser Gly Ala 
            900                 905                 910         


Pro Pro Thr Asp Leu Gln Lys Met Val Met Gly Asn Thr Lys Pro Val 
        915                 920                 925             


Glu Leu Ile Leu Asp Gly Lys Thr Val Ala Ile Cys Cys Ala Thr Gly 
    930                 935                 940                 


Val Phe Gly Thr Ala Tyr Leu Val Pro Arg His Leu Phe Ala Glu Lys 
945                 950                 955                 960 


Tyr Asp Lys Ile Met Leu Asp Gly Arg Ala Met Thr Asp Ser Asp Tyr 
                965                 970                 975     


Arg Val Phe Glu Phe Glu Ile Lys Val Lys Gly Gln Asp Met Leu Ser 
            980                 985                 990         


Asp Ala Ala Leu Met Val Leu His  Arg Gly Asn Arg Val  Arg Asp Ile 
        995                 1000                 1005             


Thr Lys  His Phe Arg Asp Thr  Ala Arg Met Lys Lys  Gly Thr Pro 
    1010                 1015                 1020             


Val Val  Gly Val Val Asn Asn  Ala Asp Val Gly Arg  Leu Ile Phe 
    1025                 1030                 1035             


Ser Gly  Glu Ala Leu Thr Tyr  Lys Asp Ile Val Val  Cys Met Asp 
    1040                 1045                 1050             


Gly Asp  Thr Met Pro Gly Leu  Phe Ala Tyr Lys Ala  Ala Thr Lys 
    1055                 1060                 1065             


Ala Gly  Tyr Cys Gly Gly Ala  Val Leu Ala Lys Asp  Gly Ala Asp 
    1070                 1075                 1080             


Thr Phe  Ile Val Gly Thr His  Ser Ala Gly Gly Asn  Gly Val Gly 
    1085                 1090                 1095             


Tyr Cys  Ser Cys Val Ser Arg  Ser Met Leu Leu Arg  Met Lys Ala 
    1100                 1105                 1110             


His Val  Asp Pro Glu Pro Gln  His Glu 
    1115                 1120         


<210>  14
<211>  3378
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding wild-type polyprotein of FMDV Iraq strain

<400>  14
atgggtgctg gccagtcctc ccccgctacc ggttcccaga accagtccgg caacaccggt       60

tccatcatca acaactacta catgcagcag taccagaact ccatggacac ccaactcggc      120

gacaacgcta tctccggtgg ttccaacgag ggttccaccg acaccacctc tacccacacc      180

accaacaccc agaacaacga ctggttctcc aagctggctt cctccgcttt ctccggcctg      240

ttcggtgctc tgctggctga caagaagacc gaggaaacca ccctgctcga ggaccgtatc      300

ctgaccaccc gtaacggtca caccacctcc accacccagt cctccgtggg tgttacctac      360

ggttactcca cccaagagga ccacgtgtcc ggtcccaaca cctccggcct ggaaacccgt      420

gtggtgcagg ctgagcgctt cttcaagaag cacctgttcg actggacccc cgacaaggct      480

ttcggtcacc tcgagaagct cgagctgccc accgaccaca agggcgtgta cggtcacctg      540

gtggacagct tcgcttacat gcgtaacggc tgggacgtcg aggtgtccgc tgtgggcaac      600

cagttcaacg gtggttgcct gctggtggct atggtgcccg agtggaaaga attcacccct      660

cgcgagaagt accagctgac cctgttcccc caccagttca tctccccccg taccaacatg      720

accgctcaca tcgtggtgcc ctacctgggt gtcaaccgtt acgaccagta caagaagcac      780

aagccctgga ccctggtggt tatggtggtg tctcccctga ccactaacac cgtgtccgct      840

ggccagatca aggtgtacgc taacatcgct cccacccacg tgcacgtcgc gggcgagctg      900

ccttccaaag aaggcatcgt ccccgtcgct tgctccgacg gttacggtgg cctggtcacc      960

accgacccca agaccgctga ccccgtgtac ggcatggtgt acaacccccc tcgcaccaac     1020

taccccggtc gtttcaccaa cctgctggac gtggccgagg cttgccccac cttcctgtgc     1080

ttcgacgagg gcaagcccta cgtggtcacc cgtaccgacg agcagcgtct gctggctaag     1140

ttcgacgtgt ccctggctgc taagcacatg tccaacacct acctgtccgg tatcgctcag     1200

tactacgccc agtactccgg caccatcaac ctgcacttca tgttcaccgg ctccaccgat     1260

tccaaggctc gttacatggt ggcttacgtg ccccctggtg tcgagactcc ccccgacacc     1320

cctgagaagg ctgctcactg catccacgct gagtgggaca ccggcctgaa ctccaagttc     1380

accttctcca tcccttacgt gtccgccgct gactacgctt acaccgcttc cgacgtcgcc     1440

gagactacca acgtgcaggg ctgggtctgc atctaccaga tcacccacgg caaggctgag     1500

caggacaccc tggtcgtgtc cgtgtctgct ggcaaggact tcgaactccg tctgcccatc     1560

gacccccgtt cccagaccac caccaccggc gagtctgccg accctgtgac caccaccgtg     1620

gaaaactacg gtggcgagac tcaggtgcag cgtcgtcagc acaccgacgt gaccttcatc     1680

atggaccgtt tcgtgaagat ccagaacctg aaccctaccc acgtgatcga cctgatgcag     1740

actcaccagc acggcctcgt gggcgctctg ctgcgtgctg ctacctacta cttctccgac     1800

ctcgagatcg tcgtccgtca cgacggcaac ctgacctggg tgcccaacgg tgctcccgag     1860

gctgctctgt ctaacaccgg caaccccacc gcttacctga aggctccctt cacccgtctg     1920

gctctgccct acaccgctcc ccaccgtgtg ctggctaccg tgtacaacgg cacctccaag     1980

tactccgctg gtggcaccgg tcgtcgtggc gacttgggtc ctctggctgc tcgtgtggct     2040

gctcagctgc ccgcttcctt caacttcggt gctatccagg ctaccaccat ccacgaactc     2100

ctcgtgcgta tgaagcgtgc tgagctgtac tgcccccgtc ccctgctggc tgtggaagtg     2160

tcctcccagg accgtcacaa gcagaagatc atcgctcccg ctaagcagct gctgaacttc     2220

gacctgctga agctggctgg cgacgtggaa tccaaccccg gtcccttctt cttcgctgac     2280

gtgcgttcca acttctctaa gctggtggac actatcaacc agatgcaaga ggacatgtcc     2340

accaagcacg gtcccgactt caaccgtctg gtgtccgctt tcgaggaact ggctaccggt     2400

gtcaaggcta tccgtaccgg cctggacgag gctaagccct ggtacaagct gatcaagctg     2460

ctgtcccgtc tgtcctgcat ggctgctgtc gctgctcgtt ccaaggaccc cgtgctggtc     2520

gctatcatgc tggccgacac cggcttggag cgtcagcgtc ctctgaaagt ccgcgctaag     2580

ctgccccagc aagagggccc gtacgctggt cccctcgagc gtcagaagcc cctgaaggtt     2640

aaagccaagg ctcccgtggt caaagaaggc ccatacgagg gtcccgtgaa gaagcccgtc     2700

gctctcaagg tcaaggccaa gaacctgatc gtgaccgagt ccggtgctcc ccccaccgac     2760

ctgcaaaaga tggtcatggg caacaccaag cccgtcgagc tgatcctgga cggcaagacc     2820

gtggctatct gctgcgctac cggcgtgttc ggtactgctt acctggtgcc ccgtcacctg     2880

ttcgctgaga agtacgacaa gatcatgctg gacggtcgtg ctatgaccga ctccgactac     2940

cgtgtgttcg agttcgagat caaagtcaag ggccaggaca tgctgtccga cgctgctctg     3000

atggtgctgc accgtggcaa ccgtgtgcgt gacatcacca agcacttccg tgacaccgct     3060

cgtatgaaga agggcacccc cgtcgtcggt gtcgtgaaca acgctgacgt gggtcgtctg     3120

atcttctccg gcgaggctct gacctacaag gacatcgtcg tgtgcatgga tggcgacacc     3180

atgcctggcc tgttcgctta caaggctgct accaaggctg gttactgcgg tggtgctgtc     3240

ctggctaagg acggtgctga caccttcatc gtgggcaccc actccgctgg cggaaacggt     3300

gtcggttact gctcctgcgt gtcccgttcc atgctgctgc gcatgaaggc tcacgtggac     3360

cccgagcccc agcacgag                                                   3378


<210>  15
<211>  3366
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding wild-type polyprotein of FMDV Asia strain

<400>  15
atgggtgctg gccagtcctc ccctgctacc ggttcccaga accagtccgg caacaccggt       60

tccatcatca acaactacta catgcagcag taccagaact ccatggacac ccagctcggc      120

gacaacgcta tctccggtgg ttccaacgag ggttccaccg acaccacctc cacccacacc      180

aacaacaccc agaacaacga ctggttctcc cgtctggctt cctccgcttt ctccggcctg      240

ttcggtgctc tgctggctga caagaagacc gaggaaacca ccctgctcga ggaccgtatc      300

ctgaccaccc gtaacggtca caccacctct accacccagt cctctgtggg tgtcacctac      360

ggttacgctg tggctgagga cgctgtgtcc ggtcccaaca cctccggcct ggaaacccgt      420

gtgcagcagg ctgagcgctt cttcaagaag cacctgttcg actggacccc caacctggct      480

ttcggtcact gctactacct cgagctgccc accgagcaca agggcgtgta cggttccctg      540

atgggctcct acgcttacat gcgtaacggc tgggacatcg aagtgaccgc tgtgggcaac      600

cagttcaacg gtggttgcct gctggtggct ctggtgcccg agctgaaaga actggacacc      660

cgtcagaagt accagctgac cctgttcccc caccagttca tcaacccccg taccaacatg      720

accgctcaca tcaacgtgcc ctacgtgggt atcaaccgtt acgaccagta cgctctgcac      780

aagccctgga ccctggtcgt gatggtggtg gctcccctga ccgtcaagac cggtggctcc      840

gagcagatca aggtgtacat gaacgctgct cccacctacg tgcacgtggc cggcgagctg      900

ccctccaaag aaggcatcgt ccccgtcgct tgcgctgacg gttacggcaa catggtcacc      960

accgacccca agaccgctga ccccgtgtac ggcaaggtgt tcaacccccc tcgtaccaac     1020

ctgcccggtc gttttaccaa cttcctcgac gtggccgagg cttgccccac cttcctgcgt     1080

ttcggcgagg tccccttcgt caagactgtg aactccggcg accgtctgct ggctaagttc     1140

gacgtgtccc tggctgctgg tcacatgtcc aacacctacc tggctggcct ggctcagtac     1200

tacacccagt actccggcac catgaacgtc cacttcatgt tcaccggtcc caccgacgct     1260

aaggctcgtt acatggtggc ttacgtgccc cctggcatga ccccccctac cgaccctgaa     1320

cacgctgctc actgcatcca ctccgagtgg gacaccggcc tgaactccaa gttcaccttc     1380

tccatccctt acctgtccgc tgctgactac gcctacaccg cttccgatgt cgccgagact     1440

acctccgtgc agggctgggt ttgcatctac cagatcaccc acggcaaggc tgagggcgac     1500

gctctggtgg tgtccgtgtc cgctggcaag gacttcgagt tccgtctgcc cgtggacgct     1560

cgtcagcaga ccaccaccac cggcgagtcc gctgacccag tgaccaccac cgtggaaaac     1620

tacggtggcg agactcagac cgctcgtcgc ctgcacaccg acgtggcctt catcctggac     1680

cgtttcgtga agctgaccgc tcccaagaac atccagaccc tggacctgat gcagatcccc     1740

tcccacaccc tcgtgggcgc tctgctgcgt tccgctacct actacttctc cgacctggaa     1800

gtcgctctgg tccacaccgg tcccgtgacc tgggtgccca acggtgctcc caaggacgct     1860

ctgaacaacc agaccaaccc caccgcttac cagaagcagc ccatcacccg cctggctctg     1920

ccttacaccg ctccccaccg tgtcctggct actgtgtaca acggcaagac cgcttacggc     1980

gaaaccacct cccgtcgtgg cgacatggct gctctggctc agcgtctgtc cgctcgtctg     2040

cccacctcct tcaactacgg tgctgtgaag gctgacacca tcaccgagct gctgatccgt     2100

atgaagcgtg ctgagactta ctgcccccgt cccctgctgg ctctggacac cacccaggac     2160

cgtcgcaagc aagagatcat cgctcccgag aagcaggtcc tgaacttcga cctgctgaag     2220

ctggctggcg acgtcgagtc caaccccggt cccttcttct tcgctgacgt gcgttccaac     2280

ttctccaagc tggtggacac catcaaccag atgcaagagg acatgtccac caagcacggt     2340

cccgacttca accgtctggt gtccgctttc gaggaactgg ctaccggtgt caaggctatc     2400

cgtaccggcc tggacgaggc taagccctgg tacaagctga tcaagctgct gtcccgtctg     2460

tcctgcatgg ctgctgtcgc tgctcgttcc aaggaccccg tgctggtcgc tatcatgctg     2520

gccgacaccg gcttggagcg ccagcgtcct ctgaaggttc gcgctaagct gcctcagcaa     2580

gagggacctt acgctggtcc cctcgagcgt cagaagcccc tgaaggtcaa ggctaaggct     2640

cccgtggtca aagaaggccc ctacgagggt cccgtgaaga agcccgtcgc tctcaaggtc     2700

aaggccaaga acctgatcgt gaccgagtcc ggtgctcccc ccaccgacct gcaaaagatg     2760

gtcatgggca acaccaagcc cgtcgagctg atcctggacg gaaagaccgt ggctatctgc     2820

tgcgctaccg gcgtgttcgg aaccgcttac ctggtgcccc gtcacctgtt cgctgagaag     2880

tacgacaaga tcatgctgga cggtcgtgct atgaccgact ccgactaccg tgtgttcgag     2940

ttcgagatca aggtcaaggg ccaggacatg ctctccgacg ctgctctgat ggtgctgcac     3000

cgtggcaacc gtgtgcgtga catcaccaag cacttccgtg acaccgctcg tatgaagaag     3060

ggcacccccg tcgtcggtgt cgtgaacaac gctgacgtgg gtcgtctgat cttctccggc     3120

gaggctctga cctacaagga catcgtcgtg tgcatggacg gcgataccat gcctggcctg     3180

ttcgcttaca aggctgctac caaggctggt tactgcggtg gtgctgtgct ggccaaggac     3240

ggtgctgaca ccttcatcgt gggcacccac tccgctggtg gcaacggtgt cggttactgc     3300

tcctgcgtgt cccgttccat gctgctgcgt atgaaggctc acgtggaccc cgagccccag     3360

cacgag                                                                3366


<210>  16
<211>  1184
<212>  PRT
<213>  artificial sequence

<220>
<223>  FMDV capsid protein in adenovirus

<400>  16

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Thr Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu 
                85                  90                  95      


Glu Asp Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr 
            100                 105                 110         


Gln Ser Ser Val Gly Val Thr His Gly Tyr Ser Thr Glu Glu Asp His 
        115                 120                 125             


Val Ala Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala 
    130                 135                 140                 


Glu Arg Phe Tyr Lys Lys Tyr Leu Phe Asp Trp Thr Thr Asp Lys Ala 
145                 150                 155                 160 


Phe Gly His Leu Glu Lys Leu Glu Leu Pro Ser Asp His His Gly Val 
                165                 170                 175     


Phe Gly Cys Leu Val Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp 
            180                 185                 190         


Val Glu Val Ser Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu 
        195                 200                 205             


Val Ala Met Val Pro Glu Trp Lys Glu Phe Asp Thr Arg Glu Lys Tyr 
    210                 215                 220                 


Gln Leu Thr Leu Phe Pro His Gln Phe Ile Ser Pro Arg Thr Asn Met 
225                 230                 235                 240 


Thr Ala His Ile Thr Val Pro Tyr Leu Gly Val Asn Arg Tyr Asp Gln 
                245                 250                 255     


Tyr Lys Lys His Lys Pro Trp Thr Leu Val Val Met Val Val Ser Pro 
            260                 265                 270         


Leu Thr Val Asn Asn Thr Ser Ala Ala Gln Ile Lys Val Tyr Ala Asn 
        275                 280                 285             


Ile Ala Pro Thr Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu 
    290                 295                 300                 


Gly Ile Phe Pro Val Ala Cys Ala Asp Gly Tyr Gly Gly Leu Val Thr 
305                 310                 315                 320 


Thr Asp Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val Tyr Asn Pro 
                325                 330                 335     


Pro Arg Thr Asn Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala 
            340                 345                 350         


Glu Ala Cys Pro Thr Phe Leu Cys Phe Asp Asp Gly Lys Pro Tyr Val 
        355                 360                 365             


Thr Thr Arg Thr Asp Asp Thr Arg Leu Leu Ala Lys Phe Asp Leu Ser 
    370                 375                 380                 


Leu Ala Ala Lys His Met Ser Asn Thr Tyr Leu Ser Gly Ile Ala Gln 
385                 390                 395                 400 


Tyr Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr 
                405                 410                 415     


Gly Ser Thr Asp Ser Lys Ala Arg Tyr Met Val Ala Tyr Ile Pro Pro 
            420                 425                 430         


Gly Val Glu Thr Pro Pro Asp Thr Pro Glu Arg Ala Ala His Cys Ile 
        435                 440                 445             


His Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile 
    450                 455                 460                 


Pro Tyr Val Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala 
465                 470                 475                 480 


Glu Thr Ile Asn Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His 
                485                 490                 495     


Gly Lys Ala Glu Asn Asp Thr Leu Val Val Ser Val Ser Ala Gly Lys 
            500                 505                 510         


Asp Phe Glu Leu Arg Leu Pro Ile Asp Pro Arg Gln Gln Thr Thr Ala 
        515                 520                 525             


Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly 
    530                 535                 540                 


Gly Glu Thr Gln Ile Gln Arg Arg His His Thr Asp Ile Gly Phe Ile 
545                 550                 555                 560 


Met Asp Arg Phe Val Lys Ile Gln Ser Leu Ser Pro Thr His Val Ile 
                565                 570                 575     


Asp Leu Met Gln Ala His Gln His Gly Leu Val Gly Ala Leu Leu Arg 
            580                 585                 590         


Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile Val Val Arg His Glu 
        595                 600                 605             


Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Ser Ala Leu Leu 
    610                 615                 620                 


Asn Thr Ser Asn Pro Thr Ala Tyr Asn Lys Ala Pro Phe Thr Arg Leu 
625                 630                 635                 640 


Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn 
                645                 650                 655     


Gly Thr Ser Lys Tyr Ala Val Gly Gly Ser Gly Arg Arg Gly Asp Met 
            660                 665                 670         


Gly Ser Leu Ala Ala Arg Val Val Lys Gln Leu Pro Ala Ser Phe Asn 
        675                 680                 685             


Tyr Gly Ala Ile Lys Ala Asp Ala Ile His Glu Leu Leu Val Arg Met 
    690                 695                 700                 


Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Leu Leu Ala Ile Glu Val 
705                 710                 715                 720 


Ser Ser Gln Asp Arg His Lys Gln Lys Ile Ile Ala Pro Ala Lys Gln 
                725                 730                 735     


Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
            740                 745                 750         


Pro Gly Pro Phe Phe Phe Ala Asp Val Arg Ser Asn Phe Ser Lys Leu 
        755                 760                 765             


Val Asp Thr Ile Asn Gln Met Gln Glu Asp Met Ser Thr Lys His Gly 
    770                 775                 780                 


Pro Asp Phe Asn Arg Leu Val Ser Ala Phe Glu Glu Leu Ala Thr Gly 
785                 790                 795                 800 


Val Lys Ala Ile Arg Thr Gly Leu Asp Glu Ala Lys Pro Trp Tyr Lys 
                805                 810                 815     


Leu Ile Lys Leu Leu Ser Arg Leu Ser Cys Met Ala Ala Val Ala Ala 
            820                 825                 830         


Arg Ser Lys Asp Pro Val Leu Val Ala Ile Met Leu Ala Asp Thr Gly 
        835                 840                 845             


Leu Glu Ile Leu Asp Ser Thr Phe Val Val Lys Lys Ile Ser Asp Ser 
    850                 855                 860                 


Leu Ser Ser Leu Phe His Val Pro Ala Pro Val Phe Ser Phe Gly Ala 
865                 870                 875                 880 


Pro Ile Leu Leu Ala Gly Leu Val Lys Val Ala Ser Ser Phe Phe Arg 
                885                 890                 895     


Ser Thr Pro Glu Asp Leu Glu Arg Ala Glu Lys Gln Arg Gln Arg Pro 
            900                 905                 910         


Leu Lys Val Arg Ala Lys Leu Pro Gln Gln Glu Gly Pro Tyr Ala Gly 
        915                 920                 925             


Pro Leu Glu Arg Gln Lys Pro Leu Lys Val Lys Ala Lys Ala Pro Val 
    930                 935                 940                 


Val Lys Glu Gly Pro Tyr Glu Gly Pro Val Lys Lys Pro Val Ala Leu 
945                 950                 955                 960 


Lys Val Lys Ala Lys Asn Leu Ile Val Thr Glu Ser Gly Ala Pro Pro 
                965                 970                 975     


Thr Asp Leu Gln Lys Met Val Met Gly Asn Thr Lys Pro Val Glu Leu 
            980                 985                 990         


Ile Leu Asp Gly Lys Thr Val Ala  Ile Cys Cys Ala Thr  Gly Val Phe 
        995                 1000                 1005             


Gly Thr  Ala Tyr Leu Val Pro  Arg His Leu Phe Ala  Glu Lys Tyr 
    1010                 1015                 1020             


Asp Lys  Ile Met Leu Asp Gly  Arg Ala Met Thr Asp  Ser Asp Tyr 
    1025                 1030                 1035             


Arg Val  Phe Glu Phe Glu Ile  Lys Val Lys Gly Gln  Asp Met Leu 
    1040                 1045                 1050             


Ser Asp  Ala Ala Leu Met Val  Leu His Arg Gly Asn  Arg Val Arg 
    1055                 1060                 1065             


Asp Ile  Thr Lys His Phe Arg  Asp Thr Ala Arg Met  Lys Lys Gly 
    1070                 1075                 1080             


Thr Pro  Val Val Gly Val Val  Asn Asn Ala Asp Val  Gly Arg Leu 
    1085                 1090                 1095             


Ile Phe  Ser Gly Glu Ala Leu  Thr Tyr Lys Asp Ile  Val Val Thr 
    1100                 1105                 1110             


Met Asp  Gly Asp Thr Met Pro  Gly Leu Phe Ala Tyr  Lys Ala Ala 
    1115                 1120                 1125             


Thr Lys  Ala Gly Tyr Cys Gly  Gly Ala Val Leu Ala  Lys Asp Gly 
    1130                 1135                 1140             


Ala Asp  Thr Phe Ile Val Gly  Thr His Ser Ala Gly  Gly Asn Gly 
    1145                 1150                 1155             


Val Gly  Tyr Cys Ser Cys Val  Ser Arg Ser Met Leu  Leu Arg Met 
    1160                 1165                 1170             


Lys Ala  His Val Asp Pro Glu  Pro Gln His Glu 
    1175                 1180                 


<210>  17
<211>  3552
<212>  DNA
<213>  artificial sequence

<220>
<223>  Codon-optimized polynucleotide encoding FMDV capsid precursor

<400>  17
atgggggctg ggcagtcctc tcccgccaca ggctcacaga atcagtcagg caacacaggg       60

tctattatca acaattatta tatgcagcag taccagaact ccatggacac ccagctggga      120

gataacgcca tctccggcgg aagcaatgag gggtccacag acaccacaag cacccacacc      180

acaaacacac agaacaatga ttggttcagc aagctggcct ccagcgcttt taccggactc      240

ttcggggccc tgctcgctga caagaaaacc gaggaaacca cactgctcga ggatcgcatc      300

ctgaccacaa ggaacggcca caccacatcc accacacagt cttcagtggg agtcacccac      360

gggtacagca cagaggaaga ccatgtggcc ggcccaaata cctctggact ggaaacacgc      420

gtggtccagg ccgagcggtt ttacaagaaa tatctgttcg actggaccac agataaggcc      480

tttggccacc tggagaaact ggaactccct tcagatcacc atggcgtgtt cggatgtctg      540

gtcgactcct acgcctatat gcgcaacggc tgggatgtgg aagtctccgc cgtgggaaac      600

cagtttaatg gaggatgcct gctcgtggct atggtcccag agtggaagga attcgacacc      660

agggagaaat accagctgac actctttcct caccagttca tctcccccag aacaaacatg      720

accgcccata ttaccgtgcc atacctgggc gtcaatcgct acgaccagta taagaaacac      780

aagccttgga ccctggtggt catggtggtc tcacccctca cagtgaacaa tacctccgcc      840

gctcagatca aagtctacgc caacattgct cccacctatg tgcacgtcgc cggggaactg      900

ccatccaagg agggcatctt ccctgtggcc tgtgctgacg ggtacggagg gctggtcacc      960

acagacccca agaccgccga tccagcttac ggcaaagtgt ataacccccc aaggaccaat     1020

taccccggaa gattcacaaa cctgctcgat gtggccgagg cttgcccaac ctttctgtgt     1080

ttcgacgatg gaaagcctta cgtgaccaca agaacagacg atacccgact gctcgccaag     1140

ttcgacctga gcctcgccgc taaacacatg tctaacacct acctgtcagg gatcgcccag     1200

tactataccc agtattccgg cacaattaat ctgcatttta tgttcacagg atctaccgac     1260

tcaaaggcca gatacatggt ggcttatatc cctcccggag tcgaaacacc acctgacacc     1320

cctgagcgag ctgctcactg catccatgcc gaatgggata ccgggctgaa ctccaagttt     1380

acattcagca ttccctacgt gtctgccgct gactacgcct ataccgctag cgatacagcc     1440

gagaccatca acgtgcaggg gtgggtctgt atctaccaga ttacccacgg caaagccgaa     1500

aatgacacac tggtggtctc tgtgtcagcc gggaaggact tcgagctgcg actccccatc     1560

gatccacgac agcagaccac agctaccgga gagtccgctg accctgtgac cacaaccgtc     1620

gaaaactacg gcggagagac ccagattcag cgccggcacc atacagacat cggctttatt     1680

atggatcgct tcgtgaagat ccagtccctg agccccaccc acgtgattga cctcatgcag     1740

gctcaccagc atggactggt gggagctctg ctccgagctg ctacctacta tttctccgat     1800

ctggaaatcg tggtccggca tgagggaaac ctgacctggg tgcctaatgg ggcccccgag     1860

tcagctctgc tcaacacatc caatcccacc gcctacaaca aagctccatt caccagactg     1920

gccctcccat atacagctcc tcaccgagtg ctggctaccg tctacaatgg cacaagcaag     1980

tatgctgtgg gaggctctgg aaggagaggg gacatgggca gcctcgctgc tcgagtggtc     2040

aagcagctgc cagcttcttt caactacgga gccatcaaag ccgatgctat tcacgaactg     2100

ctcgtgcgaa tgaagcgcgc cgagctgtat tgccccaggc cactgctcgc catcgaggtg     2160

tccagccagg acagacataa gcagaaaatc attgccccag ctaagcagct gctcaacttt     2220

gacctgctca aactggccgg agatgtggaa agcaatcctg ggcccttctt tttcgccgac     2280

gtgaggtcca acttcagcaa actggtcgac accatcaatc agatgcagga ggatatgtca     2340

accaagcacg gccccgactt taaccggctg gtgtccgcct tcgaggaact cgctaccggc     2400

gtgaaggcca tcaggacagg actggacgag gccaaaccat ggtacaagct gatcaagctg     2460

ctctctcgcc tctcatgtat ggctgctgtg gctgctcgga gcaaggaccc cgtgctggtc     2520

gccatcatgc tcgctgacac cggcctggag attctcgatt ctacatttgt ggtcaagaaa     2580

atctctgact cactgtcttc actcttccac gtgccagccc ctgtcttttc cttcggagct     2640

ccaattctgc tcgctggact ggtgaaagtc gcctccagct ttttccggtc caccccagag     2700

gacctggaaa gggccgagaa gcagcgtcag agacctctga aagtgagagc taagctccca     2760

cagcaggaag gaccttacgc tggcccgttg gagagacaga aaccgctgaa agtgaaagca     2820

aaagccccgg tcgtcaagga aggaccttac gagggaccgg tgaagaagcc tgtcgctttg     2880

aaagtgaaag ctaagaactt gatagtcact gagagtggtg ccccaccgac cgacttgcaa     2940

aagatggtca tgggcaacac aaagcctgtt gagctcatcc ttgacgggaa gacagtagcc     3000

atctgttgtg ctactggagt gtttggcact gcttacctcg tgcctcgtca tcttttcgca     3060

gagaagtatg acaagatcat gctggatggc agagccatga cagacagtga ctacagagtg     3120

tttgagtttg agattaaagt aaaaggacag gacatgctct cagacgctgc gctcatggtg     3180

ctccaccgtg ggaaccgcgt gagagatatc acgaaacact ttcgtgatac agcaagaatg     3240

aagaaaggca cccccgtcgt cggtgtggtc aacaacgccg acgttgggag actgattttc     3300

tctggtgagg ccctcaccta caaggatatt gtagtgacca tggacggaga caccatgcct     3360

ggcctctttg cctacaaagc cgccaccaag gcaggctact gtggaggagc cgttctcgcc     3420

aaggacgggg ccgacacttt catcgtcggc actcactccg caggaggcaa tggagttgga     3480

tactgctcat gcgtttccag gtccatgctt ctcagaatga aggcacacgt tgaccctgaa     3540

ccacaacacg ag                                                         3552


<210>  18
<211>  745
<212>  DNA
<213>  artificial sequence

<220>
<223>  CMV promoter

<400>  18
tttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg       60

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga      120

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat      180

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa      240

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca      300

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca      360

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat      420

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg      480

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac      540

ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc      600

atccacgctg ttttgacctc catagaagac accgggaccg atccagcctc cgcggccggg      660

aacggtgcat tggaacgcgg attccccgtg ccaagagtga cgtaagtacc gcctatagag      720

tctataggcc cacccccttg gcttc                                            745


<210>  19
<211>  104
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic enhancer

<400>  19
cttgaggtgt ggcaggcttg agatctggcc atacacttga gtgacaatga catccacttt       60

gcctttctct ccacaggtgt ccactcccag gtccaactgc agcc                       104


<210>  20
<211>  4579
<212>  DNA
<213>  artificial sequence

<220>
<223>  CMV promoter -synthetic enhancer- codon optimized FMDV capsid 
       gene - SV40 PolyA in vAD3027

<400>  20
tttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg       60

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga      120

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat      180

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa      240

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca      300

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca      360

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat      420

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg      480

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac      540

ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc      600

atccacgctg ttttgacctc catagaagac accgggaccg atccagcctc cgcggccggg      660

aacggtgcat tggaacgcgg attccccgtg ccaagagtga cgtaagtacc gcctatagag      720

tctataggcc cacccccttg gcttccttga ggtgtggcag gcttgagatc tggccataca      780

cttgagtgac aatgacatcc actttgcctt tctctccaca ggtgtccact cccaggtcca      840

actgcagccg cggccgcatg ggggctgggc agtcctctcc cgccacaggc tcacagaatc      900

agtcaggcaa cacagggtct attatcaaca attattatat gcagcagtac cagaactcca      960

tggacaccca gctgggagat aacgccatct ccggcggaag caatgagggg tccacagaca     1020

ccacaagcac ccacaccaca aacacacaga acaatgattg gttcagcaag ctggcctcca     1080

gcgcttttac cggactcttc ggggccctgc tcgctgacaa gaaaaccgag gaaaccacac     1140

tgctcgagga tcgcatcctg accacaagga acggccacac cacatccacc acacagtctt     1200

cagtgggagt cacccacggg tacagcacag aggaagacca tgtggccggc ccaaatacct     1260

ctggactgga aacacgcgtg gtccaggccg agcggtttta caagaaatat ctgttcgact     1320

ggaccacaga taaggccttt ggccacctgg agaaactgga actcccttca gatcaccatg     1380

gcgtgttcgg atgtctggtc gactcctacg cctatatgcg caacggctgg gatgtggaag     1440

tctccgccgt gggaaaccag tttaatggag gatgcctgct cgtggctatg gtcccagagt     1500

ggaaggaatt cgacaccagg gagaaatacc agctgacact ctttcctcac cagttcatct     1560

cccccagaac aaacatgacc gcccatatta ccgtgccata cctgggcgtc aatcgctacg     1620

accagtataa gaaacacaag ccttggaccc tggtggtcat ggtggtctca cccctcacag     1680

tgaacaatac ctccgccgct cagatcaaag tctacgccaa cattgctccc acctatgtgc     1740

acgtcgccgg ggaactgcca tccaaggagg gcatcttccc tgtggcctgt gctgacgggt     1800

acggagggct ggtcaccaca gaccccaaga ccgccgatcc agcttacggc aaagtgtata     1860

accccccaag gaccaattac cccggaagat tcacaaacct gctcgatgtg gccgaggctt     1920

gcccaacctt tctgtgtttc gacgatggaa agccttacgt gaccacaaga acagacgata     1980

cccgactgct cgccaagttc gacctgagcc tcgccgctaa acacatgtct aacacctacc     2040

tgtcagggat cgcccagtac tatacccagt attccggcac aattaatctg cattttatgt     2100

tcacaggatc taccgactca aaggccagat acatggtggc ttatatccct cccggagtcg     2160

aaacaccacc tgacacccct gagcgagctg ctcactgcat ccatgccgaa tgggataccg     2220

ggctgaactc caagtttaca ttcagcattc cctacgtgtc tgccgctgac tacgcctata     2280

ccgctagcga tacagccgag accatcaacg tgcaggggtg ggtctgtatc taccagatta     2340

cccacggcaa agccgaaaat gacacactgg tggtctctgt gtcagccggg aaggacttcg     2400

agctgcgact ccccatcgat ccacgacagc agaccacagc taccggagag tccgctgacc     2460

ctgtgaccac aaccgtcgaa aactacggcg gagagaccca gattcagcgc cggcaccata     2520

cagacatcgg ctttattatg gatcgcttcg tgaagatcca gtccctgagc cccacccacg     2580

tgattgacct catgcaggct caccagcatg gactggtggg agctctgctc cgagctgcta     2640

cctactattt ctccgatctg gaaatcgtgg tccggcatga gggaaacctg acctgggtgc     2700

ctaatggggc ccccgagtca gctctgctca acacatccaa tcccaccgcc tacaacaaag     2760

ctccattcac cagactggcc ctcccatata cagctcctca ccgagtgctg gctaccgtct     2820

acaatggcac aagcaagtat gctgtgggag gctctggaag gagaggggac atgggcagcc     2880

tcgctgctcg agtggtcaag cagctgccag cttctttcaa ctacggagcc atcaaagccg     2940

atgctattca cgaactgctc gtgcgaatga agcgcgccga gctgtattgc cccaggccac     3000

tgctcgccat cgaggtgtcc agccaggaca gacataagca gaaaatcatt gccccagcta     3060

agcagctgct caactttgac ctgctcaaac tggccggaga tgtggaaagc aatcctgggc     3120

ccttcttttt cgccgacgtg aggtccaact tcagcaaact ggtcgacacc atcaatcaga     3180

tgcaggagga tatgtcaacc aagcacggcc ccgactttaa ccggctggtg tccgccttcg     3240

aggaactcgc taccggcgtg aaggccatca ggacaggact ggacgaggcc aaaccatggt     3300

acaagctgat caagctgctc tctcgcctct catgtatggc tgctgtggct gctcggagca     3360

aggaccccgt gctggtcgcc atcatgctcg ctgacaccgg cctggagatt ctcgattcta     3420

catttgtggt caagaaaatc tctgactcac tgtcttcact cttccacgtg ccagcccctg     3480

tcttttcctt cggagctcca attctgctcg ctggactggt gaaagtcgcc tccagctttt     3540

tccggtccac cccagaggac ctggaaaggg ccgagaagca gcgtcagaga cctctgaaag     3600

tgagagctaa gctcccacag caggaaggac cttacgctgg cccgttggag agacagaaac     3660

cgctgaaagt gaaagcaaaa gccccggtcg tcaaggaagg accttacgag ggaccggtga     3720

agaagcctgt cgctttgaaa gtgaaagcta agaacttgat agtcactgag agtggtgccc     3780

caccgaccga cttgcaaaag atggtcatgg gcaacacaaa gcctgttgag ctcatccttg     3840

acgggaagac agtagccatc tgttgtgcta ctggagtgtt tggcactgct tacctcgtgc     3900

ctcgtcatct tttcgcagag aagtatgaca agatcatgct ggatggcaga gccatgacag     3960

acagtgacta cagagtgttt gagtttgaga ttaaagtaaa aggacaggac atgctctcag     4020

acgctgcgct catggtgctc caccgtggga accgcgtgag agatatcacg aaacactttc     4080

gtgatacagc aagaatgaag aaaggcaccc ccgtcgtcgg tgtggtcaac aacgccgacg     4140

ttgggagact gattttctct ggtgaggccc tcacctacaa ggatattgta gtgaccatgg     4200

acggagacac catgcctggc ctctttgcct acaaagccgc caccaaggca ggctactgtg     4260

gaggagccgt tctcgccaag gacggggccg acactttcat cgtcggcact cactccgcag     4320

gaggcaatgg agttggatac tgctcatgcg tttccaggtc catgcttctc agaatgaagg     4380

cacacgttga ccctgaacca caacacgagt agtaggcggc cgctctagac tagctagaaa     4440

gatccgggaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     4500

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     4560

atgtatctta tcatgtctg                                                  4579


