                         SEQUENCE LISTING

<110>  University of Oregon
       Hampton, Jennifer
       Guillemin, Karen
 
<120>  PROTEINS INCREASING PANCREATIC BETA CELL NUMBER AND METHODS OF 
       USE

<130>  1505-93762-03

<150>  US 62/054,685
<151>  2014-09-24

<150>  US 62/167,061
<151>  2015-05-27

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  261
<212>  PRT
<213>  Aeromonas veronii

<400>  1

Met Asn Lys Arg Asn Trp Leu Leu Ala Leu Ser Leu Ser Leu Ala Phe 
1               5                   10                  15      


Ser Pro Cys Tyr Ala Asp Trp Ala Lys Leu Lys Ala Ala Ala Ser Asp 
            20                  25                  30          


Leu Gly Ala Ala Val Ser Glu Thr Ser Lys Glu Val Trp Gln Asp Val 
        35                  40                  45              


Ser Asp Phe Ser Lys Lys Ser Trp Ala Ser Ile Ser Ala Trp Gly Glu 
    50                  55                  60                  


Glu Ala Phe Asn Thr Ala Gly Val Trp Thr Asp Lys Ser Ile Ala Thr 
65                  70                  75                  80  


Gly Lys Glu Trp Leu Lys Ala Ala Asp Lys Glu Leu Asn Glu Met Leu 
                85                  90                  95      


Asn Pro Lys Thr Ala Lys Glu Ala Arg Ile Ala Ile Asn Thr Met Ala 
            100                 105                 110         


Asp Thr Ala Leu Ile Arg Leu Phe Asn Glu Gln Pro Ser Ala Lys Leu 
        115                 120                 125             


Leu Phe Asp Lys Ala Tyr Gly Tyr Ala Val Phe Asp Ser Arg Lys Phe 
    130                 135                 140                 


Ser Leu Met Leu His Thr Asn Gln Gly Ala Gly Val Ala Val Asn Arg 
145                 150                 155                 160 


Lys Thr Gly Lys His Thr Tyr Met Lys Met Phe Gly Ala Gly Leu Ala 
                165                 170                 175     


Ala Gly Ile Gly Gly Lys Phe Tyr Gln Gln Val Ile Leu Phe Glu Asp 
            180                 185                 190         


Lys Ala Arg Phe Asp Ala Phe Val Thr Gln Gly Trp Glu Ala Thr Ser 
        195                 200                 205             


Glu Val Gly Val Val Ala Gly Lys Glu Ser Ala Glu Leu Thr Ala Lys 
    210                 215                 220                 


Tyr Asn Gly Gly Met Ala Ile Tyr Gln Ile Gly Glu Lys Gly Leu Leu 
225                 230                 235                 240 


Leu Asp Ala Asn Ile Ser Gly Ser Lys Tyr Trp Ile Asp Lys Asp Leu 
                245                 250                 255     


Thr Glu Thr Ser Arg 
            260     


<210>  2
<211>  258
<212>  PRT
<213>  Aeromonas sp. ZOR0001

<400>  2

Met Asn Lys Arg Asn Trp Leu Leu Ala Leu Ser Leu Ser Leu Ala Phe 
1               5                   10                  15      


Ser Pro Cys Tyr Ala Asp Trp Ala Lys Leu Lys Ala Ala Ala Ser Asp 
            20                  25                  30          


Leu Gly Ala Ala Val Ser Glu Thr Ser Lys Glu Val Trp Gln Asp Val 
        35                  40                  45              


Ser Asp Phe Ser Lys Lys Ser Trp Ala Ser Ile Ser Ala Trp Gly Glu 
    50                  55                  60                  


Asp Ala Phe Asn Thr Ala Gly Val Trp Thr Asp Lys Ser Ile Ala Thr 
65                  70                  75                  80  


Gly Lys Glu Trp Leu Lys Ala Ala Asp Lys Glu Leu Asn Glu Met Leu 
                85                  90                  95      


Asn Pro Lys Thr Ala Lys Glu Ala Arg Ile Ala Leu Asn Thr Met Ala 
            100                 105                 110         


Asp Thr Ala Leu Ile Arg Leu Phe Asn Glu Gln Pro Ser Ala Lys Leu 
        115                 120                 125             


Leu Phe Asp Lys Ala Tyr Gly Tyr Ala Val Phe Asp Ser Arg Lys Phe 
    130                 135                 140                 


Ser Leu Met Leu His Thr Asn Gln Gly Ala Gly Val Ala Val Asn Arg 
145                 150                 155                 160 


Lys Thr Gly Lys His Thr Tyr Met Lys Met Phe Gly Ala Gly Leu Ala 
                165                 170                 175     


Ala Gly Ile Gly Gly Lys Phe Tyr Gln Gln Val Val Leu Phe Glu Asp 
            180                 185                 190         


Lys Ala Arg Phe Asp Ala Phe Val Thr Gln Gly Trp Glu Ala Thr Ser 
        195                 200                 205             


Glu Val Gly Val Val Ala Gly Lys Glu Ser Ala Glu Leu Thr Ala Lys 
    210                 215                 220                 


Tyr Asn Gly Gly Met Ala Ile Tyr Gln Ile Gly Glu Lys Gly Leu Leu 
225                 230                 235                 240 


Leu Asp Ala Asn Ile Ser Gly Ser Lys Tyr Trp Ile Asp Lys Asp Leu 
                245                 250                 255     


Thr Gln 
        


<210>  3
<211>  258
<212>  PRT
<213>  Aeromonas sp. ZOR0002

<400>  3

Met Lys Ile Arg Phe Leu Val Ile Ala Thr Ala Leu Ala Leu Ala Ser 
1               5                   10                  15      


Thr Pro Gly Leu Ala Asp Trp Ala Lys Leu Lys Glu Ala Ala Ser Glu 
            20                  25                  30          


Leu Gly Thr Ala Val Ser Asp Thr Ser Lys Glu Ala Trp Lys Gly Ile 
        35                  40                  45              


Thr Asp Phe Ser Lys Glu Thr Trp Glu Ser Val Ser Ser Trp Gly Ala 
    50                  55                  60                  


Glu Ala Tyr Asn Lys Ala Gly Ala Trp Thr Ala Glu Ser Ala Ala Thr 
65                  70                  75                  80  


Gly Lys Glu Trp Leu Thr Ala Ala Asp Lys Lys Leu Asp Thr Met Leu 
                85                  90                  95      


Glu Pro Lys Thr Pro Glu Glu Ala Arg Thr Ala Leu Asp Thr Met Ala 
            100                 105                 110         


Asp Thr Ala Leu Val Arg Leu Phe Asn Glu Gln Pro Ser Ala Lys Leu 
        115                 120                 125             


Leu Phe Asp Lys Ala Tyr Gly Tyr Ala Val Phe Asp Ser Arg Lys Phe 
    130                 135                 140                 


Ser Leu Met Ile His Thr Asn Gln Gly Ala Gly Val Ala Val Asn Arg 
145                 150                 155                 160 


Thr Ser Gly Lys His Thr Tyr Met Lys Met Phe Gly Ala Gly Leu Ala 
                165                 170                 175     


Ala Gly Ile Gly Gly Lys Phe Tyr Gln Gln Val Ile Leu Phe Glu Asp 
            180                 185                 190         


Lys Ala Arg Phe Asp Ala Phe Val Ser Lys Gly Trp Glu Ala Thr Ser 
        195                 200                 205             


Glu Val Gly Ala Val Ala Gly Lys Glu Ser Ala Glu Leu Thr Ala Lys 
    210                 215                 220                 


Tyr Asn Gly Gly Met Ala Ile Tyr Gln Ile Gly Glu Lys Gly Leu Leu 
225                 230                 235                 240 


Leu Asp Ala Asn Ile Ser Gly Ser Lys Tyr Trp Leu Asp Asp Asp Leu 
                245                 250                 255     


Asn Lys 
        


<210>  4
<211>  193
<212>  PRT
<213>  Shewanella sp. ZOR0012

<400>  4

Met Lys Ser Ile Leu Ser Phe Val Val Ala Ser Thr Cys Leu Ile Ala 
1               5                   10                  15      


Ser Leu Leu Thr Pro Val Ala Gln Ala Asp Asp Ser Tyr Thr Glu Ala 
            20                  25                  30          


Leu Lys Asn Phe His Gln Ala Lys Glu Thr Arg Lys Phe Phe Asp Thr 
        35                  40                  45              


Ala Tyr Gly Tyr Ala Leu Phe Pro Thr Val Gly Lys Gly Gly Ile Gly 
    50                  55                  60                  


Ile Gly Ala Ala Tyr Gly Lys Gly Arg Val Phe Gln Ala Gly Gln Tyr 
65                  70                  75                  80  


Met Gly Asp Ser Ser Leu Thr Gln Leu Ser Ile Gly Phe Gln Leu Gly 
                85                  90                  95      


Gly Gln Ala Tyr Ser Glu Ile Ile Phe Phe Lys Asp Ala Lys Ser Tyr 
            100                 105                 110         


Asn Glu Phe Thr Ser Gly Ser Phe Glu Phe Asp Ala Gln Ala Ser Ala 
        115                 120                 125             


Val Ala Ile Asn Met Gly Ala Asn Ala Lys Ala Gly Thr Thr Gly Asn 
    130                 135                 140                 


Ser Ala Gly Ala Gly Gln Ala Gly Gly Asn Gln Ser Ala Thr Ala Ala 
145                 150                 155                 160 


Tyr Ile Asn Gly Met Ala Val Phe Thr Val Ala Lys Gly Gly Leu Met 
                165                 170                 175     


Phe Glu Ala Ala Leu Ala Gly Gln Ser Phe Thr Phe Glu Pro Arg Gly 
            180                 185                 190         


Asn 
    


<210>  5
<211>  195
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  5

Met Lys Leu Gln Thr Leu Phe Leu Val Ala Met Thr Ala Leu Ala Gly 
1               5                   10                  15      


Cys Ser Ala Gln Gly Asp Thr Ala Ser Gln Gln Arg Ala Ser Ile Gln 
            20                  25                  30          


Lys Met Arg Asn Glu Thr Leu Thr Lys Leu Tyr Thr Leu Gln Pro Glu 
        35                  40                  45              


Ala Arg Ser Asp Ile Gln His Ala Lys Gly Tyr Ala Val Phe Ala Asn 
    50                  55                  60                  


Asn Ser Ser Lys Ile Leu Leu Phe Gly Phe Gly Ser Gly Tyr Gly Val 
65                  70                  75                  80  


Val Arg Asp Thr Ala Ser Gly Lys Asp Thr Tyr Met Lys Met Ala Gln 
                85                  90                  95      


Gly Gly Ala Gly Leu Gly Ile Gly Ile Lys Gln Gln Arg Thr Val Leu 
            100                 105                 110         


Val Phe His Asp Lys Ala Ala Leu Asp Arg Phe Ile Arg Gln Gly Tyr 
        115                 120                 125             


Met Val Gly Ala Asp Ala Asn Ala Ala Ala Lys Tyr Asp Asp Lys Gly 
    130                 135                 140                 


Ile Ala Pro Ile Ala Ala Ser Ala Asn Gly Val Ala Lys Asp Thr Ser 
145                 150                 155                 160 


Ser Leu Pro Ser Lys Val Asn Val Tyr Glu Ile Thr Asp Lys Gly Leu 
                165                 170                 175     


Ala Ala Gln Ala Met Val Asn Gly Tyr Lys Tyr Trp Pro Asp Asp Glu 
            180                 185                 190         


Leu Asn Pro 
        195 


<210>  6
<211>  258
<212>  PRT
<213>  Enterococcus gallinarum

<400>  6

Met Lys Ile Arg Phe Leu Val Ile Ala Thr Ala Leu Ala Leu Thr Ser 
1               5                   10                  15      


Ala Pro Gly Leu Ala Asp Trp Ala Lys Val Lys Ala Ala Ala Thr Glu 
            20                  25                  30          


Leu Gly Asn Ala Val Ser Asp Thr Ser Lys Glu Ala Trp Gln Ser Val 
        35                  40                  45              


Thr Asp Phe Ser Lys Ala Thr Trp Ala Ser Val Ser Gln Trp Gly Ser 
    50                  55                  60                  


Glu Ala Phe Asn Thr Ala Gly Ala Trp Thr Asp Lys Ser Val Ala Thr 
65                  70                  75                  80  


Gly Lys Glu Trp Leu Ala Val Ala Asp Lys Lys Leu Asp Glu Met Leu 
                85                  90                  95      


Glu Pro Lys Thr Ala Asp Glu Ala Arg Leu Ala Leu Asn Thr Met Ala 
            100                 105                 110         


Asp Thr Ala Leu Val Arg Leu Phe Asn Glu Gln Pro Ser Ala Lys Leu 
        115                 120                 125             


Leu Phe Asp Lys Ala Tyr Gly Tyr Ala Val Phe Asp Ser Arg Lys Phe 
    130                 135                 140                 


Ser Leu Met Leu His Thr Asn Gln Gly Ala Gly Val Ala Val Asn Arg 
145                 150                 155                 160 


Ala Thr Gly Lys His Thr Tyr Met Lys Met Phe Gly Ala Gly Leu Ala 
                165                 170                 175     


Ala Gly Leu Gly Gly Lys Phe Tyr Gln Gln Val Ile Leu Phe Glu Asp 
            180                 185                 190         


Lys Ala Arg Phe Asp Ala Phe Val Ser Gln Gly Trp Glu Ala Thr Ser 
        195                 200                 205             


Glu Val Gly Ala Val Ala Gly Lys Glu Ser Ala Glu Leu Thr Ala Lys 
    210                 215                 220                 


Tyr Asn Gly Gly Met Ala Ile Tyr Gln Ile Gly Glu Lys Gly Leu Leu 
225                 230                 235                 240 


Leu Asp Ala Asn Ile Ser Gly Ser Lys Tyr Trp Val Asp Lys Asp Leu 
                245                 250                 255     


Thr Arg 
        


<210>  7
<211>  256
<212>  PRT
<213>  Photobacterium sp.

<400>  7

Met Lys Leu Lys Leu Ile Val Val Ala Leu Cys Leu Ala Val Ala Pro 
1               5                   10                  15      


Ala His Ala Ser Trp Glu Glu Ile Lys Lys Ala Ala Ser Asp Leu Gly 
            20                  25                  30          


Gln Lys Val Ser Glu Gly Ser Lys Lys Ala Trp Glu Asp Val Thr Asp 
        35                  40                  45              


Phe Ser Lys Glu Thr Trp Asp Ser Val Ser Glu Trp Gly Glu Asp Ala 
    50                  55                  60                  


Phe Asn Thr Ala Gly Glu Trp Thr Asp Ala Ser Ile Glu Lys Gly Lys 
65                  70                  75                  80  


Glu Trp Leu Glu Ala Gly Glu Ala Lys Leu Asn Glu Met Leu Glu Pro 
                85                  90                  95      


Glu Thr Pro Glu Glu Ala Arg Leu Ala Leu Asp Thr Met Ser Asp Thr 
            100                 105                 110         


Ala Leu Val Arg Leu Phe Asn Glu Glu Pro Ser Ala Lys Leu Leu Phe 
        115                 120                 125             


Asp Thr Ala Tyr Gly Tyr Ala Val Phe Asp Ser Arg Lys Phe Ser Leu 
    130                 135                 140                 


Met Leu His Thr Asn Gln Gly Ala Gly Val Ala Val Asp Arg Lys Thr 
145                 150                 155                 160 


Gly Lys Arg Thr Tyr Met Lys Met Phe Gly Ala Gly Leu Ala Leu Gly 
                165                 170                 175     


Leu Gly Gly Lys Phe Tyr Gln Gln Leu Ile Phe Phe Glu Asp Lys Lys 
            180                 185                 190         


Thr Phe Asp Ser Phe Val Lys Asp Gly Trp Glu Ala Thr Ser Glu Ala 
        195                 200                 205             


Gly Ala Val Ala Gly Thr Glu Ser Ala Glu Leu Thr Ala Lys Tyr Asn 
    210                 215                 220                 


Gly Gly Met Ala Ile Tyr Gln Ile Gly Glu Lys Gly Leu Leu Leu Asp 
225                 230                 235                 240 


Ala Asn Ile Ser Gly Ser Lys Tyr Trp Val Asp Glu Asp Leu Thr Gln 
                245                 250                 255     


<210>  8
<211>  786
<212>  DNA
<213>  Aeromonas veronii

<400>  8
atgaacaagc gtaactggtt gctggccttg tcactgagtc tggccttctc accctgttat       60

gccgactggg ccaagctcaa ggccgcagcg tccgatctgg gagcggcagt gagcgagacc      120

agcaaggagg tgtggcagga tgtcagcgat ttctccaaga agagctgggc ttccatctct      180

gcatggggtg aagaggcgtt caataccgcc ggggtctgga ccgacaagag catcgcgacc      240

ggcaaggagt ggctgaaggc agccgacaag gagctcaacg agatgctcaa ccccaagacg      300

gcgaaagagg cgaggatcgc gatcaatacc atggccgaca ctgcgctgat ccggttgttc      360

aacgagcagc catcagccaa gttgttgttt gacaaggctt atggttatgc ggtgttcgat      420

tcgcgcaagt tctccctgat gctgcatacc aatcaggggg ccggggtggc agtcaatcgc      480

aaaaccggca agcacaccta tatgaagatg tttggtgcgg gtctggcggc cgggattggc      540

ggcaagttct atcagcaggt gatcctgttt gaagacaagg ccagattcga tgccttcgtg      600

acccaggggt gggaagctac ctccgaagtg ggtgtggtgg ccggcaagga gagcgctgag      660

ctgaccgcca aatataatgg cggcatggcc atctaccaga ttggcgagaa gggtttgctg      720

ctcgatgcca atatctccgg ctctaaatac tggattgaca aggacttgac tgaaacgagc      780

cgctaa                                                                 786


<210>  9
<211>  777
<212>  DNA
<213>  Aeromonas sp. ZOR0001

<400>  9
atgaacaagc gtaactggtt gctggccttg tcactgagtc tggccttctc accctgttat       60

gccgactggg ccaagctcaa ggccgcagcg tccgatctgg gagcggcagt gagcgagacc      120

agcaaggagg tgtggcagga tgtcagcgat ttttccaaaa agagctgggc ctccatctcg      180

gcttggggag aggatgcctt caataccgcc ggggtctgga ccgacaagag catcgcgaca      240

ggcaaggagt ggctgaaggc agccgacaag gagctcaacg agatgctcaa ccccaagacg      300

gcgaaagagg cgaggatcgc gctcaatacc atggccgaca ctgcgctgat ccggttgttc      360

aacgagcagc catcagccaa gttgttgttt gacaaggctt atggctatgc agtgttcgat      420

tcgcgcaagt tctccctgat gctgcatacc aatcaggggg ccggggtggc agtcaatcgc      480

aaaaccggca agcacaccta tatgaagatg tttggcgcag gtctggcggc cgggattggc      540

ggcaagttct atcagcaggt ggtcctgttt gaagacaagg ccagattcga tgccttcgtg      600

acccaggggt gggaggccac ctccgaagtg ggcgtggtgg ccggcaagga gagcgccgag      660

cttaccgcca aatacaatgg cggcatggcc atctaccaga ttggtgagaa gggcctgctg      720

ctcgatgcca atatctccgg ctccaagtac tggattgaca aggacttgac tcaataa         777


<210>  10
<211>  777
<212>  DNA
<213>  Aeromonas ZOR0002

<400>  10
atgaagattc gattcctggt gatagccacg gcactggcgc tggcctcgac ccccggtctg       60

gccgactggg caaagctgaa ggaggccgcc tccgaactcg gtaccgcggt gagcgatacc      120

agcaaggagg cgtggaaggg gatcaccgat ttttccaagg agacctggga gtcggtgtcc      180

agctgggggg ccgaggccta caacaaggcg ggggcctgga cggcagagag cgcggccacc      240

ggcaaggagt ggctgaccgc cgccgacaag aagctcgaca ccatgctcga gcccaagacc      300

ccggaggagg cgagaaccgc cctcgatacc atggccgata ccgccctggt gcggctattc      360

aacgagcagc cctcggccaa gttgctgttt gacaaggctt atggctatgc ggtgttcgac      420

tcgcgcaagt tctccctgat gatccacacc aatcaggggg ccggggtggc cgtcaatcgc      480

accagtggca agcacaccta catgaagatg ttcggtgccg gtctcgcggc cgggatcggc      540

ggcaagttct accagcaggt gatcctgttc gaagacaagg cgaggttcga tgccttcgtc      600

agcaaggggt gggaagccac ctccgaggtg ggcgccgtgg cgggcaagga gagcgccgag      660

ctcaccgcca aatacaatgg cggcatggcc atctaccaga ttggcgagaa ggggctgttg      720

cttgacgcca acatctcggg ctccaagtac tggctggatg atgacctgaa caagtga         777


<210>  11
<211>  582
<212>  DNA
<213>  Shewanella sp. ZOR0012

<400>  11
atgaaatcaa ttttatcttt tgttgtcgca tcgacctgct tgattgccag cttactgaca       60

ccagttgcgc aagcagatga tagttacact gaggctttaa aaaattttca ccaagccaag      120

gaaacccgca aattttttga taccgcctat ggctacgccc tctttccaac agttggcaaa      180

ggtgggattg gtattggcgc cgcctacggc aaaggtcggg tttttcaagc gggacaatat      240

atgggagact ccagcctaac ccagctatct attggatttc aattaggtgg acaagcctat      300

agtgaaatca tcttctttaa agatgccaaa tcctacaatg agttcaccag tggcagtttt      360

gagtttgatg cccaagcctc cgcagttgcc attaatatgg gtgctaacgc caaagcaggc      420

accacaggca actcggcagg tgctggtcaa gccggtggta atcaatcggc taccgcagcc      480

tatatcaatg gtatggcggt ctttaccgtt gccaagggtg gactaatgtt tgaagccgca      540

ctggcgggac aatcttttac cttcgagcct aggggtaact aa                         582


<210>  12
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  12
gcccatatga tgaacaagcg taactggttg ctg                                    33


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  13
ggcctcgagg cggctcgttt cagtcaagtc                                        30


