                         SEQUENCE LISTING

<110>  DiMarchi, Richard D.
       Kou, Binbin
       Zhang, Fa
       Mayer, John Philip 
 
<120>  LIPIDATED AMIDE-BASED INSULIN PRODRUGS

<130>  32993-242706

<140>  62/054,670
<141>  2014-09-24

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is threonine or histidine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is asparagine, glycine, alanine, glutamine, 
       glutamate, threonine, or serine

<400>  3

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Xaa 
            20      


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<400>  4

Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Phe 
            20      


<210>  5
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe Val Lys Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Glu Lys Thr 
            20                  25                  30  


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Phe 
            20      


<210>  8
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe Val Lys Gln 
1               


<210>  9
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  10
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is phenylalanine or desamino-phenylalanine.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine and threonine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<400>  10

Xaa Val Asn Gln Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  11
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Gly Pro Glu 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  12

Phe Val Asn Gln 
1               


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is phenylalanine or desamino-phenylalanine.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine and threonine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<400>  13

Xaa Val Asn Gln Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  14
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Tyr Arg Pro Ser Glu 
1               5       


<210>  15
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is histidine, tyrosine or phenylalanine

<400>  15

His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Xaa 
            20      


<210>  16
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid orcysteic acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is histidine, tyrosine or phenylalanine

<400>  16

Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Xaa 
            20      


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  The Xaa at position 1 is histidine or a histidine analog

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Amidation

<400>  17

Xaa Ser Arg Gly Thr Phe 
1               5       


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  model synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  The Xaa at position 2 is sarcosine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  18

Lys Xaa His Ser Arg Gly Thr Phe 
1               5               


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 5 is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine, threonine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is serine, arginine, ornithine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is isoleucine or serine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is aspartic acid or serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is tyrosine, arginine, ornathine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is glutamine, glutamic acid, arginine, 
       ornithine, alanine, lysine or leucine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is methionine, asparagine, glutamine, glutamic
       acid, aspartic acid or threonine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine, serine, valine, 
       threonine, isoleucine, leucine, glutamine, glutamic acid, 
       asparagine, aspartic acid, histidine, tryptophan, tyrosine, or 
       methionine

<400>  19

Gly Ile Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Xaa Leu Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa Tyr Cys Xaa 
            20      


<210>  20
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is aspartic acid, glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or threonine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 12 is glutamic acid, aspartic acid or asparagine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or 4-amino-phenylalanine

<400>  20

Xaa Leu Cys Gly Xaa Xaa Leu Val Xaa Xaa Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Xaa Xaa Gly Phe Xaa 
            20      


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is d-histidine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is d-threonine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is d-arginine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa at position 5 is d-threonine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa at position 6 is d-phenylalanine

<400>  21

Xaa Xaa Xaa Gly Xaa Xaa 
1               5       


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  22

Gly Gly Gly Pro Gly Lys Arg 
1               5           


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  23

Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  24

Gly Gly Gly Gly Gly Lys Arg 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  25

Arg Arg Gly Gly Gly Gly Gly 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  26

Gly Gly Ala Pro Gly Asp Val Lys Arg 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  27

Arg Arg Ala Pro Gly Asp Val Gly Gly 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  28

Gly Gly Tyr Pro Gly Asp Val Lys Arg 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  29

Arg Arg Tyr Pro Gly Asp Val Gly Gly 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  30

Gly Gly His Pro Gly Asp Val Lys Arg 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  31

Arg Arg His Pro Gly Asp Val Gly Gly 
1               5                   


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  32

Arg Arg Gly Pro Gly Gly Gly 
1               5           


<210>  33
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single chain human insulin analog


<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa at position 49 is 4-amino phenylalanine or 4-methoxy 
       phenylalanine

<400>  33

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ile 
            20                  25                  30          


Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn 
        35                  40                  45              


Xaa Cys Asn 
    50      


<210>  34
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain human insulin analog


<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa at position 61 is 4-amino phenylalanine or 4-methoxy 
       phenylalanine

<400>  34

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gln Pro 
            20                  25                  30          


Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys 
        35                  40                  45              


Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Xaa Cys Asn 
    50                  55                  60              


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  35

Ala Gly Arg Gly Ser Gly Lys 
1               5           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  36

Ala Gly Leu Gly Ser Gly Lys 
1               5           


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  37

Ala Gly Met Gly Ser Gly Lys 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  38

Ala Ser Trp Gly Ser Gly Lys 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  39

Thr Gly Leu Gly Ser Gly Gln 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  40

Thr Gly Leu Gly Arg Gly Lys 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  41

Thr Gly Leu Gly Ser Gly Lys 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  42

His Gly Leu Tyr Ser Gly Lys 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  43

Lys Gly Leu Gly Ser Gly Gln 
1               5           


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  44

Val Gly Leu Met Ser Gly Lys 
1               5           


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  45

Val Gly Leu Ser Ser Gly Gln 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  46

Val Gly Leu Tyr Ser Gly Lys 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  47

Val Gly Leu Ser Ser Gly Lys 
1               5           


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  48

Val Gly Met Ser Ser Gly Lys 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  49

Val Trp Ser Ser Ser Gly Lys 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  50

Val Gly Ser Ser Ser Gly Lys 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  51

Val Gly Met Ser Ser Gly Lys 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  52

Thr Gly Leu Gly Ser Gly Arg 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  53

Thr Gly Leu Gly Lys Gly Gln 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  54

Lys Gly Leu Ser Ser Gly Gln 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  55

Val Lys Leu Ser Ser Gly Gln 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  56

Val Lys Leu Ser Ser Gly Gln 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  57

Thr Gly Leu Gly Lys Gly Gln 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  58

Val Gly Leu Ser Lys Gly Gln 
1               5           


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is d-lysine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is d-sarcosine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is d-histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa at position 4 is d-threonine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa at position 5 is d-arginine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa at position 7 is d-threonine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  d-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa at position 8 is d-phenylalanine

<400>  59

Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  60

Ser Arg Val Ser Arg Arg Ser Arg 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Tyr Gly Ser Ser Ser Arg Arg 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  62

Gly Ser Ser Ser Arg Arg Ala Pro 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is ornithine

<400>  63

Gly Tyr Gly Ser Ser Ser Xaa Arg 
1               5               


<210>  64
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  65
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine ornithine or arginine

<400>  65

Xaa Leu Cys Gly Ala Xaa Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Tyr 
            20      


<210>  66
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Tyr Gly Ser Ser Ser Arg Arg 
1               5               


<210>  67
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is histidine, aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or threonin

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamic acid, aspartic acid or asparagine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or phenylalanine

<400>  67

Xaa Leu Cys Gly Xaa Xaa Leu Val Xaa Xaa Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Xaa Xaa Gly Phe Xaa Tyr Thr 
            20              


