                               SEQUENCE LISTING

<110> INTRINSIC LIFESCIENCES LLC
 
<120> HUMANIZED ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF

<130> 44546-706.601

<140>
<141>

<150> 62/053,669
<151> 2014-09-22

<160> 76    

<170> PatentIn version 3.5

<210> 1
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1
Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg 
1               5                   10                  15      


Ser Lys Cys Gly Met Cys Cys Lys Thr 
            20                  25  


<210> 2
<211> 25
<212> PRT
<213> Mus musculus

<400> 2
Asp Thr Asn Phe Pro Ile Cys Ile Phe Cys Cys Lys Cys Cys Asn Asn 
1               5                   10                  15      


Ser Gln Cys Gly Ile Cys Cys Lys Thr 
            20                  25  


<210> 3
<211> 25
<212> PRT
<213> Rattus sp.

<400> 3
Asp Thr Asn Phe Pro Ile Cys Leu Phe Cys Cys Lys Cys Cys Lys Asn 
1               5                   10                  15      


Ser Ser Cys Gly Leu Cys Cys Ile Thr 
            20                  25  


<210> 4
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4
Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys Cys Gly Met 
1               5                   10                  15      


Cys Cys Lys Thr 
            20  


<210> 5
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5
Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys Cys 
1               5                   10                  15      


Gly Met Cys Cys Lys Thr 
            20          


<210> 6
<211> 9
<212> PRT
<213> Homo sapiens

<400> 6
Asp Thr His Phe Pro Ile Cys Ile Phe 
1               5                   


<210> 7
<211> 5
<212> PRT
<213> Homo sapiens

<400> 7
Asp Thr His Phe Pro 
1               5   


<210> 8
<211> 16
<212> PRT
<213> Homo sapiens

<400> 8
Cys Cys Gly Cys Cys His Arg Ser Lys Cys Gly Met Cys Cys Lys Thr 
1               5                   10                  15      


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Asp Thr His Phe Pro Ile Cys 
1               5           


<210> 10
<211> 122
<212> PRT
<213> Homo sapiens

<400> 10
Leu Leu Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser 
1               5                   10                  15      


Leu Thr Cys Thr Val Ser Gly Gly Ser Met Ile Asn Tyr Tyr Trp Ser 
            20                  25                  30          


Trp Ile Arg Gln Pro Pro Gly Glu Arg Pro Gln Trp Leu Gly His Ile 
        35                  40                  45              


Ile Tyr Gly Gly Thr Thr Lys Tyr Asn Pro Ser Leu Glu Ser Arg Ile 
    50                  55                  60                  


Thr Ile Ser Arg Asp Ile Ser Lys Ser Gln Phe Ser Leu Arg Leu Asn 
65                  70                  75                  80  


Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Val Ala 
                85                  90                  95      


Ile Gly Val Ser Gly Phe Leu Asn Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Ser Gly Thr Ala Val Thr Val Ser Ser 
        115                 120         


<210> 11
<211> 158
<212> PRT
<213> Homo sapiens

<400> 11
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Arg Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Asp 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Glu Lys Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Asp Trp Tyr Pro Phe Asp Tyr Trp Asp Glu Gly Ile Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155             


<210> 12
<211> 121
<212> PRT
<213> Mus musculus

<400> 12
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Asn Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Asn Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Phe Thr Val Glu Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Thr Asp Tyr Tyr Ala Ser Gly Tyr Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 13
<211> 114
<212> PRT
<213> Mus musculus

<400> 13
Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Asp Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Ser Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Pro Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp 
        


<210> 14
<211> 115
<212> PRT
<213> Mus musculus

<400> 14
Asp Val Val Met Thr Gln Ser Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Ala Asn 
            20                  25                  30          


Asn Gly Arg Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp 
        115 


<210> 15
<211> 105
<212> PRT
<213> Homo sapiens

<400> 15
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
1               5                   10                  15      


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Arg Asn Leu Gly Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala 
        35                  40                  45              


Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Trp Pro Arg Thr Phe Gly 
                85                  90                  95      


Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105 


<210> 16
<211> 106
<212> PRT
<213> Mus musculus

<400> 16
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210> 17
<211> 118
<212> PRT
<213> Mus musculus

<400> 17
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Ser Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Trp Arg Arg Phe Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210> 18
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtac aacgtacgct      300

actagctggt actggggcca aggc                                             324


<210> 19
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Thr Tyr Ala Thr Ser Trp Tyr Trp Gly Gln Gly 
            100                 105             


<210> 20
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtat      120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaagtaatga ggatctgacg      300

ttcggt                                                                 306


<210> 21
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Leu Thr Phe Gly 
            100         


<210> 22
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
gggtatacct tcacaaacta tgga                                              24


<210> 23
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
ataaacacct acactggaga gcca                                              24


<210> 24
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
acaacgtacg ctactagctg gtac                                              24


<210> 25
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
gaaagtgttg atagttatgg caatagtttt                                        30


<210> 26
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
cgtgcatcc                                                                9


<210> 27
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
cagcaaagta atgaggatct gacg                                              24


<210> 28
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtat      120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaagtaatga ggatctgacg      300

ttcggc                                                                 306


<210> 29
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaac ctggccaggc tcccaggctc ctcatctatc gtgcatccaa cctagaatct      180

ggggtcccat caaggttcag tggaagtgga tctgggacag attttacttt caccatcagc      240

agcctgcagc ctgaagatat tgcaacatat tactgtcagc aaagtaatga ggatctgacg      300

ttcggc                                                                 306


<210> 30
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtat      120

cagcagaaac cagggaaagc tcctaagctc ctgatctatc gtgcatccaa cctagaatct      180

gggatcccag ccaggttcag tggcagtggg tctgggacag agttcactct caccatcagc      240

agcctgcagt ctgaagattt tgcagtttat tactgtcagc aaagtaatga ggatctgacg      300

ttcggc                                                                 306


<210> 31
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaac ctggccaggc tcccaggctc ctcatctatc gtgcatccaa cctagaatct      180

ggggtcccat caaggttcag tggaagtgga tctgggacag attttacttt caccatcagc      240

agcctgcagc ctgaagatat tgcaacatat tactgtcagc aaagtaatga ggatctgacg      300

ttcggc                                                                 306


<210> 32
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gagccagtga aagtgttgat agttatggca atagttttat gcactggttt      120

cagcagaggc caggccaatc tccaaggcgc ctaatttatc gtgcatccaa cctagaatct      180

gggatcccac ctcgattcag tggcagcggg tatggaacag attttaccct cacaattaat      240

aacatagaat ctgaggatgc tgcatattac ttctgtcagc aaagtaatga ggatctgacg      300

ttcggc                                                                 306


<210> 33
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaac ctggccaggc tcccaggctc ctcatctatc gtgcatccaa cctagaatct      180

ggggtcccat caaggttcag tggaagtgga tctgggacag attttacttt caccatcagc      240

agcctgcagc ctgaagatat tgcaacatat tactgtcagc aaagtaatga ggatctgacg      300

ttcggc                                                                 306


<210> 34
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaac ctggccaggc tcccaggctc ctcatctatc gtgcatccaa cctagaatct      180

ggggtcccat caaggttcag tggaagtgga tctgggacag attttacttt caccatcagc      240

agcctgcagc ctgaagatat tgcaacatat tactgtcagc aaagtaatga ggatctgacg      300

ttcggc                                                                 306


<210> 35
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtac aacgtacgct      300

actagctggt actggggcca ggga                                             324


<210> 36
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggttgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggaag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtac aacgtacgct      300

actagctggt actggggcca ggga                                             324


<210> 37
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggttgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggaag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtac aacgtacgct      300

actagctggt actggggcca ggga                                             324


<210> 38
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggttgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggaag atttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatct gcagcctaaa ggctgaggac actgccgtgt attactgtac aacgtacgct      300

actagctggt actggggcca ggga                                             324


<210> 39
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggttgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggaag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtac aacgtacgct      300

actagctggt actggggcca ggga                                             324


<210> 40
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
gaagtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctgggta taccttcaca aactatggaa tgaactggat ccgccagccc      120

ccagggaagg ggctggagtg gattggttgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggaag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtac aacgtacgct      300

actagctggt actggggcca ggga                                             324


<210> 41
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
gaagtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctgggta taccttcaca aactatggaa tgaactggat ccgccagccc      120

ccagggaagg ggctggagtg gattggttgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggaag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtac aacgtacgct      300

actagctggt actggggcca ggga                                             324


<210> 42
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Thr Tyr Ala Thr Ser Trp Tyr Trp Gly Gln Gly 
            100                 105             


<210> 43
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Ala Thr Ser Trp Tyr Trp Gly Gln Gly 
            100                 105             


<210> 44
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Ala Thr Ser Trp Tyr Trp Gly Gln Gly 
            100                 105             


<210> 45
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Ala Thr Ser Trp Tyr Trp Gly Gln Gly 
            100                 105             


<210> 46
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Ala Thr Ser Trp Tyr Trp Gly Gln Gly 
            100                 105             


<210> 47
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Ala Thr Ser Trp Tyr Trp Gly Gln Gly 
            100                 105             


<210> 48
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Ala Thr Ser Trp Tyr Trp Gly Gln Gly 
            100                 105             


<210> 49
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Leu Thr Phe Gly 
            100         


<210> 50
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Leu Thr Phe Gly 
            100         


<210> 51
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Leu Thr Phe Gly 
            100         


<210> 52
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Leu Thr Phe Gly 
            100         


<210> 53
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Leu Thr Phe Gly 
            100         


<210> 54
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Leu Thr Phe Gly 
            100         


<210> 55
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Arg Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Asn Ile Glu Ser Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Leu Thr Phe Gly 
            100         


<210> 56
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210> 57
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210> 58
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
1               5                   10                  15      


<210> 59
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Trp Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5                   


<210> 60
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Phe Cys 
        35              


<210> 61
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Thr Thr Tyr Ala Thr Ser Trp Tyr 
1               5               


<210> 62
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Trp Gly Gln Gly 
1               


<210> 63
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            20                  25      


<210> 64
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe 
1               5                   10  


<210> 65
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210> 66
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Arg Ala Ser 
1           


<210> 67
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Gln Gln Ser Asn Glu Asp Leu Thr 
1               5               


<210> 69
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Phe Gly 
1       


<210> 70
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 70
His His His His His His 
1               5       


<210> 71
<211> 717
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 71
atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtgcc       60

aagtgtgaca ttgtgctgac ccaatctcca gcttctttgg ctgtgtctct agggcagagg      120

gccaccatat cctgcagagc cagtgaaagt gttgatagtt atggcaatag ttttatgcac      180

tggtatcagc agaaaccagg acagccaccc aaactcctca tctatcgtgc atccaaccta      240

gaatctggga tccctgccag gttcagtggc agtgggtcta ggacagactt caccctcacc      300

attaatcctg tggaggctga tgatgttgca acctattact gtcagcaaag taatgaggat      360

ctgacgttcg gccaagggac caaggtggaa atcaaacgta cggtggctgc accatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         717


<210> 72
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Ser Asn Glu Asp Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210> 73
<211> 1404
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 73
atggccacaa ccatggagtt tgggctgagc tggctttttc ttgtggctat tttaaaaggt       60

gtccagtgtc agatccagtt ggtgcagtct ggacctgagc tgaagaagcc tggagagaca      120

gtcaagatct cctgcaaggc ttctgggtat accttcacaa actatggaat gaactgggtg      180

aagcaggctc caggaaaggg tttaaagtgg atgggctgga taaacaccta cactggagag      240

ccaacatatg ctgatgactt caagggacgg tttgccttct ctttggaaac ctctgccagc      300

actgcctatt tgcagatcaa caacctcaaa aatgaggaca cggctacata tttctgtaca      360

acgtacgcta ctagctggta ctggggccag ggaacgctgg tcaccgtcag ctcagcctcc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tcagcaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaa                                            1404


<210> 74
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Met Ala Thr Thr Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala 
1               5                   10                  15      


Ile Leu Lys Gly Val Gln Cys Gln Ile Gln Leu Val Gln Ser Gly Pro 
            20                  25                  30          


Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu 
65                  70                  75                  80  


Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu 
                85                  90                  95      


Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu 
            100                 105                 110         


Asp Thr Ala Thr Tyr Phe Cys Thr Thr Tyr Ala Thr Ser Trp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210> 75
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 75
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtac aacgtacgct      300

actagctggt actggggcca aggcaccact ctcacagtct cctca                      345


<210> 76
<211> 331
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 76
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtat      120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaagtaatga ggatctgacg      300

ttcggtggag gcaccaagct ggaaatcaaa c                                     331


