                         SEQUENCE LISTING

<110>  GlaxoSmithKline Biologicals SA and The Chancellor Masters 
       and Scholars of the University of Oxford
 
<120>  NOVEL METHODS FOR INDUCING AN IMMUNE RESPONSE

<130>  VB65766

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  424
<212>  PRT
<213>  Plasmodium falciparum

<400>  1

Met Met Ala Pro Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
1               5                   10                  15      


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
            20                  25                  30          


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
        35                  40                  45              


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    50                  55                  60                  


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Lys 
65                  70                  75                  80  


Asn Asn Gln Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp Pro Asn 
                85                  90                  95      


Arg Asn Val Asp Glu Asn Ala Asn Ala Asn Ser Ala Val Lys Asn Asn 
            100                 105                 110         


Asn Asn Glu Glu Pro Ser Asp Lys His Ile Lys Glu Tyr Leu Asn Lys 
        115                 120                 125             


Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys 
    130                 135                 140                 


Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro 
145                 150                 155                 160 


Lys Asp Glu Leu Asp Tyr Ala Asn Asp Ile Glu Lys Lys Ile Cys Lys 
                165                 170                 175     


Met Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn Ser Ser Ile Gly 
            180                 185                 190         


Leu Gly Pro Val Thr Asn Met Glu Asn Ile Thr Ser Gly Phe Leu Gly 
        195                 200                 205             


Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu 
    210                 215                 220                 


Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu 
225                 230                 235                 240 


Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser 
                245                 250                 255     


Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp 
            260                 265                 270         


Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys 
        275                 280                 285             


Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 
    290                 295                 300                 


Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Asn Thr Gly Pro Cys Lys 
305                 310                 315                 320 


Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys 
                325                 330                 335     


Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser 
            340                 345                 350         


Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe 
        355                 360                 365             


Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu 
    370                 375                 380                 


Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly 
385                 390                 395                 400 


Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile 
                405                 410                 415     


Phe Phe Cys Leu Trp Val Tyr Ile 
            420                 


<210>  2
<211>  790
<212>  PRT
<213>  Plasmodium falciparum

<400>  2

Met Gly Met Ile Asn Ala Tyr Leu Asp Lys Leu Ile Ser Lys Tyr Glu 
1               5                   10                  15      


Asp Glu Ile Ser Tyr Ile Pro Ser Ala Glu Lys Ile Gly Ser Lys Pro 
            20                  25                  30          


Asn Asp Lys Ser Leu Tyr Lys Pro Lys Asp Glu Leu Asp Tyr Lys Pro 
        35                  40                  45              


Ile Val Gln Tyr Asp Asn Phe Gly Ser Ala Ser Lys Asn Lys Glu Lys 
    50                  55                  60                  


Ala Leu Ile Ile Gly Ile Ala Gly Gly Leu Ala Leu Leu Met Asn Pro 
65                  70                  75                  80  


Asn Asp Pro Asn Arg Asn Val Arg Ser His Leu Gly Asn Val Lys Tyr 
                85                  90                  95      


Leu Val Lys Ser Leu Tyr Asp Glu His Ile Leu Leu Met Asp Cys Ser 
            100                 105                 110         


Gly Ser Ile Gly Ser Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn 
        115                 120                 125             


Ala Asn Pro Asn Val Gln Val His Phe Gln Pro Leu Pro Pro Ala Val 
    130                 135                 140                 


Val Lys Leu Gln Phe Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
145                 150                 155                 160 


Glu Gly Ser Tyr Leu Asn Lys Ile Gln Asn Ser Leu Met Glu Lys Leu 
                165                 170                 175     


Lys Glu Leu Glu Lys Ala Thr Ser Val Leu Ala Gly Leu Gly Ser Asn 
            180                 185                 190         


Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asp 
        195                 200                 205             


Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Lys Gly Thr Arg Ser Arg 
    210                 215                 220                 


Lys Arg Glu Gly Ser Lys Ile Met Asn His Leu Gly Asn Val Lys Tyr 
225                 230                 235                 240 


Leu Val Ile Val Phe Leu Ile Phe Phe Asp Leu Phe Leu Val Asn Gly 
                245                 250                 255     


Arg Asp Val Gln Asn Asn Ile Val Asp Glu Ile Lys Tyr Ser Glu Glu 
            260                 265                 270         


Val Cys Asn Asp Gln Val Asp Leu Tyr Leu Leu Met Asp Cys Ser Gly 
        275                 280                 285             


Ser Ile Arg Arg His Asn Trp Val Asn His Ala Val Pro Leu Ala Met 
    290                 295                 300                 


Lys Leu Ile Gln Gln Leu Asn Leu Asn Asp Asn Ala Ile His Leu Tyr 
305                 310                 315                 320 


Val Asn Val Phe Ser Asn Asn Ala Lys Glu Ile Ile Arg Leu His Ser 
                325                 330                 335     


Asp Ala Ser Lys Asn Lys Glu Lys Ala Leu Ile Ile Ile Arg Ser Leu 
            340                 345                 350         


Leu Ser Thr Asn Leu Pro Tyr Gly Arg Thr Asn Leu Thr Asp Ala Leu 
        355                 360                 365             


Leu Gln Val Arg Lys His Leu Asn Asp Arg Ile Asn Arg Glu Asn Ala 
    370                 375                 380                 


Asn Gln Leu Val Val Ile Leu Thr Asp Gly Ile Pro Asp Ser Ile Gln 
385                 390                 395                 400 


Asp Ser Leu Lys Glu Ser Arg Lys Leu Ser Asp Arg Gly Val Lys Ile 
                405                 410                 415     


Ala Val Phe Gly Ile Gly Gln Gly Ile Asn Val Ala Phe Asn Arg Phe 
            420                 425                 430         


Leu Val Gly Cys His Pro Ser Asp Gly Lys Cys Asn Leu Tyr Ala Asp 
        435                 440                 445             


Ser Ala Trp Glu Asn Val Lys Asn Val Ile Gly Pro Phe Met Lys Ala 
    450                 455                 460                 


Val Cys Val Glu Val Glu Lys Thr Ala Ser Cys Gly Val Trp Asp Glu 
465                 470                 475                 480 


Trp Ser Pro Cys Ser Val Thr Cys Gly Lys Gly Thr Arg Ser Arg Lys 
                485                 490                 495     


Arg Glu Ile Leu His Glu Gly Cys Thr Ser Glu Ile Gln Glu Gln Cys 
            500                 505                 510         


Glu Glu Glu Arg Cys Pro Pro Lys Trp Glu Pro Leu Asp Val Pro Asp 
        515                 520                 525             


Glu Pro Glu Asp Asp Gln Pro Arg Pro Arg Gly Asp Asn Ser Ser Val 
    530                 535                 540                 


Gln Lys Pro Glu Glu Asn Ile Ile Asp Asn Asn Pro Gln Glu Pro Ser 
545                 550                 555                 560 


Pro Asn Pro Glu Glu Gly Lys Asp Glu Asn Pro Asn Gly Phe Asp Leu 
                565                 570                 575     


Asp Glu Asn Pro Glu Asn Pro Pro Asn Pro Asp Ile Pro Glu Gln Lys 
            580                 585                 590         


Pro Asn Ile Pro Glu Asp Ser Glu Lys Glu Val Pro Ser Asp Val Pro 
        595                 600                 605             


Lys Asn Pro Glu Asp Asp Arg Glu Glu Asn Phe Asp Ile Pro Lys Lys 
    610                 615                 620                 


Pro Glu Asn Lys His Asp Asn Gln Asn Asn Leu Pro Asn Asp Lys Ser 
625                 630                 635                 640 


Asp Arg Asn Ile Pro Tyr Ser Pro Leu Pro Pro Lys Val Leu Asp Asn 
                645                 650                 655     


Glu Arg Lys Gln Ser Asp Pro Gln Ser Gln Asp Asn Asn Gly Asn Arg 
            660                 665                 670         


His Val Pro Asn Ser Glu Asp Arg Glu Thr Arg Pro His Gly Arg Asn 
        675                 680                 685             


Asn Glu Asn Arg Ser Tyr Asn Arg Lys Tyr Asn Asp Thr Pro Lys His 
    690                 695                 700                 


Pro Glu Arg Glu Glu His Glu Lys Pro Asp Asn Asn Lys Lys Lys Gly 
705                 710                 715                 720 


Glu Ser Asp Asn Lys Tyr Lys Ile Ala Gly Gly Ile Ala Gly Gly Leu 
                725                 730                 735     


Ala Leu Leu Ala Cys Ala Gly Leu Ala Tyr Lys Phe Val Val Pro Gly 
            740                 745                 750         


Ala Ala Thr Pro Tyr Ala Gly Glu Pro Ala Pro Phe Asp Glu Thr Leu 
        755                 760                 765             


Gly Glu Glu Asp Lys Asp Leu Asp Glu Pro Glu Gln Phe Arg Leu Pro 
    770                 775                 780                 


Glu Glu Asn Glu Trp Asn 
785                 790 


<210>  3
<211>  2402
<212>  DNA
<213>  Plasmodium falciparum

<400>  3
gatcccgccg ccaccatggg tatgatcaac gcctacttgg acaagttgat ctccaagtac       60

gaagacgaaa tctcctacat cccatctgcc gaaaagatcg gatctaagcc gaacgacaag      120

tccttgtata aacctaagga cgaattggac tacaagccaa tcgttcaata cgacaacttc      180

ggatctgcct ccaagaacaa ggaaaaggct ttgatcatcg gtatcgctgg tggtttggcc      240

ttgttgatga accctaatga cccaaacaga aacgtcagat ctcacttggg taacgttaag      300

tacttggtta agtctttgta cgatgaacac atcttattga tggactgttc tggttctatt      360

ggatctgacc caaacgctaa cccaaacgtt gacccaaacg ccaacccaaa cgtccaagtt      420

cacttccaac cattgcctcc ggccgttgtc aagttgcaat tcatcaaggc caactctaag      480

ttcatcggta tcaccgaagg atcttacttg aacaaaattc aaaactcttt gatggaaaag      540

ttgaaagaat tggaaaaggc tacttctgtc ttggctggtt tgggatctaa cgctaatcca      600

aacgcaaatc cgaacgccaa tcctaacgcg aatcccgacg aatggtctcc atgttctgtc      660

acttgtggta agggtactcg ctctagaaag agagaaggat ccaaaataat gaatcatctt      720

gggaatgtta aatatttagt cattgtgttt ttgattttct ttgatttgtt tctagttaat      780

ggtagagatg tgcaaaacaa tatagtggat gaaataaaat atagtgaaga agtatgtaat      840

gatcaggtag atctttacct tctaatggat tgttctggaa gtatacgtcg tcataattgg      900

gtgaaccatg cagtacctct agctatgaaa ttgatacaac aattaaatct taatgataat      960

gcaattcact tatatgttaa tgttttttca aacaatgcaa aagaaattat tagattacat     1020

agtgatgcat ctaaaaacaa agagaaggct ttaattatta taaggtcact cttaagtaca     1080

aatcttccat atggtagaac aaacttaact gatgcactgt tacaagtaag aaaacattta     1140

aatgaccgaa tcaatagaga gaatgctaat caattagttg ttatattaac agatggaatt     1200

ccagatagta ttcaagattc attaaaagaa tcaagaaaat taagtgatcg tggtgttaaa     1260

atagctgttt ttggtattgg acaaggtatt aatgtagctt tcaacagatt tcttgtaggt     1320

tgtcatccat cagatggtaa atgtaacttg tatgctgatt ctgcatggga aaatgtaaaa     1380

aatgttatcg gaccctttat gaaggctgtt tgtgttgaag tagaaaaaac agcaagttgt     1440

ggtgtttggg acgaatggtc tccatgtagt gtaacttgtg gtaaaggtac caggtcaaga     1500

aaaagagaaa tcttacacga aggatgtaca agtgaaatac aagaacaatg tgaagaagaa     1560

agatgtcctc caaaatggga accattagat gttccagatg aacccgaaga tgatcaacct     1620

agaccaagag gagataattc ttctgtccaa aaaccagaag aaaatataat agataataat     1680

ccacaagaac cttcaccaaa tccagaagaa ggaaaggatg aaaatccaaa cggatttgat     1740

ttagatgaaa atccagaaaa tccaccaaat ccagatattc ctgaacaaaa accaaatata     1800

cctgaagatt cagaaaaaga agtaccttct gatgttccaa aaaatccaga agacgatcga     1860

gaagaaaact ttgatattcc aaagaaaccc gaaaataagc acgataatca aaataattta     1920

ccaaatgata aaagtgatag aaatattcca tattcaccat tacctccaaa agttttggat     1980

aatgaaagga aacaaagtga cccccaaagt caagataata atggaaatag gcacgtacct     2040

aatagtgaag atagagaaac acgtccacat ggtagaaata atgaaaatag atcatacaat     2100

agaaaatata acgatactcc aaaacatcct gaaagggaag aacatgaaaa gccagataat     2160

aataaaaaaa aaggagaatc agataataaa tataaaattg caggtggaat agctggagga     2220

ttagctttac tcgcatgtgc tggacttgct tataaattcg tagtaccagg agcagcaaca     2280

ccctatgccg gagaacctgc accttttgat gaaacattag gtgaagaaga taaagatttg     2340

gacgaacctg aacaattcag attacctgaa gaaaacgagt ggaattaaat ataatacgga     2400

tc                                                                    2402


