                         SEQUENCE LISTING

<110>  Cell Signaling Technology, Inc.
 
<120>  Altered Antibodies and Methods of Making the Same

<130>  CST-342 PCT

<140>  PCT/US15/50960
<141>  2015-09-18

<150>  62/052,232
<151>  2014-09-18

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1

Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Met Pro Gly Gly 
1               5                   10                  15      


Ile Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asn Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Arg Tyr Ile Ser Tyr Gly Gly Ser Ala Tyr Tyr Lys Ser Trp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95  


<210>  2
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  2

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Ser Ser Gly Ser Ala Tyr Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Arg Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95  


<210>  3
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Gln Glu Gln Gln Lys Glu Ser Gly Gly Arg Leu Val Met Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Trp Ile Ser Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Met Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95  


<210>  4
<211>  73
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Gly Val Ser Gly Phe Ser Ile Ser Ser Tyr Ala Met Ile Trp Val His 
1               5                   10                  15      


Gln Ala Pro Glu Glu Gly Leu Glu Tyr Ile Arg Ile Ile Asn Thr Gly 
            20                  25                  30          


Gly Ser Ala Tyr Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Ile Ser 
        35                  40                  45              


Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr Ser Leu Thr Ala Ala 
    50                  55                  60                  


Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
65                  70              


<210>  5
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  5

Glu Asp Gln Leu Val Glu Ser Arg Gly Gly Leu Leu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Cys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Thr Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95  


<210>  6
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Gln Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ile Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Ile Ser Ser Tyr 
            20                  25                  30          


Arg Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Gly Gly Ser Ala Tyr Tyr Lys Ser Trp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Ala Ser Asp Lys Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95  


<210>  7
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  7

Gln Glu Gln Leu Lys Glu Ser Gly Gly Val Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ile Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Ile Ser Ser Tyr 
            20                  25                  30          


Arg Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Ile Ile Tyr Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Ala Ala Asp Met Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95  


<210>  8
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  8

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Asn Ser Tyr Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  9
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  9

Gln Ser Leu Glu Glu Ser Arg Gly Gly Leu Ile Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Ile Gly 
        35                  40                  45              


Tyr Ile Ser Tyr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  10
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  10

Gln Glu Gln Leu Lys Glu Ser Gly Arg Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Asn 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Asn Thr Gly Gly Ser Thr Asn Tyr Ala Ser Trp Ala Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Tyr Phe Cys Ala Arg 
                85                  90                  95  


<210>  11
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  11

Gln Ser Val Glu Glu Ser Arg Gly Gly Leu Ile Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          


Val Ile Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Thr Ile Gly Ser Ser Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  12
<211>  97
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  12

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Ile Ile Ile Ser Ser Asp Asn Thr Gln Asn Thr Val Ser Leu 
65                  70                  75                  80  


Leu Met Asn Ser Leu Ser Ala Arg Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Gly 
    


<210>  13
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  13

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Gly Ser Ser Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  14
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  14

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Ser Ser Gly Ser Ala Tyr Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95  


<210>  15
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  15

Gln Glu Gln Leu Glu Glu Ser Gly Gly His Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Ser Ala Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Met Asp Leu Lys Met 
65                  70                  75                  80  


Asn Ser Pro Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95  


<210>  16
<211>  98
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  16

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg 
        


<210>  17
<211>  99
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  17

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Tyr Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu 
        35                  40                  45              


Ile Ala Cys Ile Tyr Thr Ser Ser Gly Ser Thr Trp Tyr Ala Ser Trp 
    50                  55                  60                  


Val Asn Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Leu Asn Thr Val 
65                  70                  75                  80  


Asp Leu Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg 
            


<210>  18
<211>  95
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  18

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Thr Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Gly 
                85                  90                  95  


<210>  19
<211>  99
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  19

Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg 
            


<210>  20
<211>  98
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  20

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Tyr Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Leu Asn Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Val Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg 
        


<210>  21
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  21

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Ala Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr Gly 
            20                  25                  30          


Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Asp Ile Asn Gly Arg Thr Tyr Tyr Ala Thr Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ala Thr Ile Thr Arg Asn Val Asn Glu Asn Thr Val Thr Leu Arg 
65                  70                  75                  80  


Val Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  22
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  22

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Tyr Ile Ser Phe Thr Asn Thr Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  23
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  23

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Asn 
            20                  25                  30          


Ile Gly Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Tyr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  24
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  24

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Asn 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Asn Glu Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Thr Ser Tyr Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Pro Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  25
<211>  97
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  25

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Asn Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Val Asn Tyr Asp Gly Ser Thr His Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Ala Thr Leu 
65                  70                  75                  80  


Lys Met Thr Ser Leu Thr Gly Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg 
    


<210>  26
<211>  97
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  26

Gln Ser Leu Gly Glu Ser Arg Gly Gly Leu Ile Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Cys Ile Asn Ser Tyr Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Glu 
    


<210>  27
<211>  97
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  27

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Ser Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          


Val Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Cys Ile Gly 
        35                  40                  45              


Trp Ile Ser Thr Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Ala 
    


<210>  28
<211>  97
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  28

Gln Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ile Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Asn Met Gly Trp Val Pro Pro Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Gly Gly Ser Pro Tyr Cys Thr Ser Trp Ala Gly 
    50                  55                  60                  


Lys Arg Ser Thr Ile Thr Arg Asn Thr Ser Glu Asn Thr Val Thr Leu 
65                  70                  75                  80  


Glu Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Leu Cys Ala 
                85                  90                  95      


Lys 
    


<210>  29
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  29

Gln Thr Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr His Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Pro 
            20                  25                  30          


Ile Ile Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Thr Asn Thr Tyr Gly Ser Pro Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  30
<211>  97
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  30

Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Met Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Ser Gly Gly Thr Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Ser Thr Ile Ser Arg Asn Thr Lys Glu Asn Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg 
    


<210>  31
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  31

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Glu Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Arg Asp Tyr Arg 
            20                  25                  30          


Thr Gly Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Val Val Ala 
        35                  40                  45              


Tyr Ile Arg Gly Asp Gly Val Ile Tyr Tyr Ala Ser Trp Ala Lys Lys 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


<210>  32
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  32

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Ala Thr Glu Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Leu Ser Gly Phe Ser Leu Asn Asn Asn Ala 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Met Ile Tyr Gly Ser Gly Ala Thr Tyr Tyr Ala Ser Trp Val Ser Gly 
    50                  55                  60                  


Arg Ala Thr Ile Thr Arg Asp Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Asp Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  33
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  33

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Met Ser 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Asn Arg Val Ser Thr Thr Tyr Tyr Thr Thr Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Phe Cys Thr Arg 
                85                  90                  95      


<210>  34
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  34

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Ile Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Ile 
            20                  25                  30          


Ile Phe Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Ile Gly 
        35                  40                  45              


Tyr Ile His Gly Gly Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asp Thr Lys Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Ala Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  35
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  35

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Ile Ser Ser Tyr Arg 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Val Ile Gly 
        35                  40                  45              


Tyr Ile Arg Gly Asp Gly Val Thr Tyr Cys Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Ala Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


<210>  36
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  36

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Lys Pro Asp Glu Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Arg Cys Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ala Ile Asn Thr Asp Gly Ser Pro Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Phe Thr Ile Ser Ser Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  37
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  37

Gln Ser Leu Glu Glu Phe Gly Gly Gly Leu Ile Arg Pro Ala Ser Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Glu Val Gly 
            20                  25                  30          


Val Ile Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Ile Gly 
        35                  40                  45              


Tyr Ile Ser Tyr Arg Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Lys Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Val Thr Gly Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  38
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  38

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Glu Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Lys Tyr Gly 
            20                  25                  30          


Val Met Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Ala Tyr Ser Gly Asn Thr Tyr Tyr Thr Thr Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  39
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  39

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Gly 
            20                  25                  30          


Val Ile Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ser Ile Ala Ser Gly Gly Ser Ala Gly Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Ala 
                85                  90                  95      


<210>  40
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  40

Gln Ser Val Glu Glu Ser Arg Gly Gly Leu Ile Lys Pro Ala Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Gly 
            20                  25                  30          


Val Ile Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Thr Ile Asp Ile Gly Val Thr Ala Phe Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Lys Asn Thr Asn Glu Asn Thr Val Thr Leu Arg 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Ser 
                85                  90                  95      


<210>  41
<211>  94
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  41

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  


<210>  42
<211>  97
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  42

Gln Gln Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
1               5                   10                  15      


Leu Lys Leu Cys Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr 
            20                  25                  30          


Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Cys Ile Tyr Ala Gly Ser Gly Ser Thr His Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Gln Ser Thr Val Cys Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg 
    


<210>  43
<211>  97
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  43

Gln Lys Gln Leu Val Glu Ser Gly Gly Gly Leu Asp Gln Pro Ala Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Asp Ser Gly Phe Thr Leu Ser Ser Asn 
            20                  25                  30          


Ala Met Cys Trp Val His Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Asp Ser Tyr Gly Ser Thr Asn Tyr Val Ser Arg Val Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Ser Asp Asn Thr Gln Asn Met Val Asp Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Thr Ala Ala Asp Met Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg 
    


