
                                SEQUENCE LISTING

<110> PECHAN, Peter
      SCARIA, Abraham
      ARDINGER, Jeffery
      

<120> ADENO-ASSOCIATED VIRAL VECTORS FOR
  TREATING MYOCILIN (MYOC) GLAUCOMA
  

<130> 159792012540

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<150> 62/051,229          
<151> 2014-09-16  

<160> 24

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 272
<212> PRT
<213> Homo sapiens

<400> 1
Met His Leu Arg Leu Ile Ser Trp Leu Phe Ile Ile Leu Asn Phe Met
 1               5                  10                  15      
Glu Tyr Ile Gly Ser Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg
            20                  25                  30          
Met His Pro Asn Val Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys
        35                  40                  45              
Ser Asp Tyr Asn Gly Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala
    50                  55                  60                  
Leu Glu Arg Ile Gly Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys
65                  70                  75                  80  
Pro Ser Gly Tyr Tyr Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr
                85                  90                  95      
Lys Cys Lys Ala Asp Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr
            100                 105                 110         
Lys Cys Lys Ser Gly Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn
        115                 120                 125             
Cys Pro Glu Gly Leu Glu Ala Asn Asn His Thr Met Glu Cys Val Ser
    130                 135                 140                 
Ile Val His Cys Glu Val Ser Glu Trp Asn Pro Trp Ser Pro Cys Thr
145                 150                 155                 160 
Lys Lys Gly Lys Thr Cys Gly Phe Lys Arg Gly Thr Glu Thr Arg Val
                165                 170                 175     
Arg Glu Ile Ile Gln His Pro Ser Ala Lys Gly Asn Leu Cys Pro Pro
            180                 185                 190         
Thr Asn Glu Thr Arg Lys Cys Thr Val Gln Arg Lys Lys Cys Gln Lys
        195                 200                 205             
Gly Glu Arg Gly Lys Lys Gly Arg Glu Arg Lys Arg Lys Lys Pro Asn
    210                 215                 220                 
Lys Gly Glu Ser Lys Glu Ala Ile Pro Asp Ser Lys Ser Leu Glu Ser
225                 230                 235                 240 
Ser Lys Glu Ile Pro Glu Gln Arg Glu Asn Lys Gln Gln Gln Lys Lys
                245                 250                 255     
Arg Lys Val Gln Asp Lys Gln Lys Ser Val Ser Val Ser Thr Val His
            260                 265                 270         


<210> 2
<211> 819
<212> DNA
<213> Homo sapiens

<400> 2
atgcacttgc gactgatttc ttggcttttt atcattttga actttatgga atacatcggc 60
agccaaaacg cctcccgggg aaggcgccag cgaagaatgc atcctaacgt tagtcaaggc 120
tgccaaggag gctgtgcaac atgctcagat tacaatggat gtttgtcatg taagcccaga 180
ctattttttg ctctggaaag aattggcatg aagcagattg gagtatgtct ctcttcatgt 240
ccaagtggat attatggaac tcgatatcca gatataaata agtgtacaaa atgcaaagct 300
gactgtgata cctgtttcaa caaaaatttc tgcacaaaat gtaaaagtgg attttactta 360
caccttggaa agtgccttga caattgccca gaagggttgg aagccaacaa ccatactatg 420
gagtgtgtca gtattgtgca ctgtgaggtc agtgaatgga atccttggag tccatgcacg 480
aagaagggaa aaacatgtgg cttcaaaaga gggactgaaa cacgggtccg agaaataata 540
cagcatcctt cagcaaaggg taacctgtgt cccccaacaa atgagacaag aaagtgtaca 600
gtgcaaagga agaagtgtca gaagggagaa cgaggaaaaa aaggaaggga gaggaaaaga 660
aaaaaaccta ataaaggaga aagtaaagaa gcaatacctg acagcaaaag tctggaatcc 720
agcaaagaaa tcccagagca acgagaaaac aaacagcagc agaagaagcg aaaagtccaa 780
gataaacaga aatcggtatc agtcagcact gtacactag                        819

<210> 3
<211> 502
<212> PRT
<213> Homo sapiens

<400> 3
Met Arg Phe Phe Cys Ala Arg Cys Cys Ser Phe Gly Pro Glu Met Pro
 1               5                  10                  15      
Ala Val Gln Leu Leu Leu Leu Ala Cys Leu Val Trp Asp Val Gly Ala
            20                  25                  30          
Arg Thr Ala Gln Leu Arg Lys Ala Asn Asp Gln Ser Gly Arg Cys Gln
        35                  40                  45              
Tyr Thr Phe Ser Val Asp Asn Glu Ser Ser Cys Pro Glu Gln Ser Gln
    50                  55                  60                  
Ala Met Ser Val Ile His Asn Leu Gln Arg Asp Ser Ser Thr Gln Arg
65                  70                  75                  80  
Leu Asp Leu Glu Ala Thr Lys Ala Arg Leu Ser Ser Leu Glu Ser Leu
                85                  90                  95      
Leu His Gln Leu Thr Leu Asp Gln Ala Ala Arg Pro Gln Glu Thr Gln
            100                 105                 110         
Glu Gly Leu Gln Arg Glu Leu Gly Thr Leu Arg Arg Glu Arg Asp Gln
        115                 120                 125             
Leu Glu Thr Gln Thr Arg Glu Leu Glu Thr Ala Tyr Ser Asn Leu Leu
    130                 135                 140                 
Arg Asp Lys Ser Val Leu Glu Glu Glu Lys Lys Arg Leu Arg Gln Glu
145                 150                 155                 160 
Asn Glu Asn Leu Ala Arg Arg Leu Glu Ser Ser Ser Gln Glu Val Ala
                165                 170                 175     
Arg Leu Arg Arg Gly Gln Cys Pro Gln Thr Arg Asp Thr Ala Arg Ala
            180                 185                 190         
Val Pro Pro Gly Ser Arg Glu Val Ser Thr Trp Asn Leu Asp Thr Leu
        195                 200                 205             
Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val Pro Ala Ser Arg
    210                 215                 220                 
Ile Leu Lys Glu Ser Pro Ser Gly Tyr Leu Arg Ser Gly Glu Gly Asp
225                 230                 235                 240 
Thr Gly Cys Gly Glu Leu Val Trp Val Gly Glu Pro Leu Thr Leu Arg
                245                 250                 255     
Thr Ala Glu Thr Ile Thr Gly Lys Tyr Gly Val Trp Met Arg Asp Pro
            260                 265                 270         
Lys Pro Thr Tyr Pro Tyr Thr Gln Glu Thr Thr Trp Arg Ile Asp Thr
        275                 280                 285             
Val Gly Thr Asp Val Arg Gln Val Phe Glu Tyr Asp Leu Ile Ser Gln
    290                 295                 300                 
Phe Met Gln Gly Tyr Pro Ser Lys Val His Ile Leu Pro Arg Pro Leu
305                 310                 315                 320 
Glu Ser Thr Gly Ala Val Val Tyr Ser Gly Ser Leu Tyr Phe Gln Gly
                325                 330                 335     
Ala Glu Ser Arg Thr Val Ile Arg Tyr Glu Leu Asn Thr Glu Thr Val
            340                 345                 350         
Lys Ala Glu Lys Glu Ile Pro Gly Ala Gly Tyr His Gly Gln Phe Pro
        355                 360                 365             
Tyr Ser Trp Gly Gly Tyr Thr Asp Ile Asp Leu Ala Val Asp Glu Ala
    370                 375                 380                 
Gly Leu Trp Val Ile Tyr Ser Thr Asp Glu Ala Lys Gly Ala Ile Val
385                 390                 395                 400 
Leu Ser Lys Leu Asn Pro Glu Asn Leu Glu Leu Glu Gln Thr Trp Glu
                405                 410                 415     
Thr Asn Ile Arg Lys Gln Ser Val Ala Asn Ala Phe Ile Ile Cys Gly
            420                 425                 430         
Thr Leu Tyr Thr Val Ser Ser Tyr Thr Ser Ala Asp Ala Thr Val Asn
        435                 440                 445             
Phe Ala Tyr Asp Thr Gly Thr Gly Ile Ser Lys Thr Leu Thr Ile Pro
    450                 455                 460                 
Phe Lys Asn Arg Tyr Lys Tyr Ser Ser Met Ile Asp Tyr Asn Pro Leu
465                 470                 475                 480 
Glu Lys Lys Leu Phe Ala Trp Asp Asn Leu Asn Met Val Thr Tyr Asp
                485                 490                 495     
Ile Lys Leu Ser Lys Met
            500         


<210> 4
<211> 1515
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
atgaggttct tctgtgcacg ttgctgcagc tttgggcctg agatgccagc tgtccagctg 60
ctgcttctgg cctgcctggt gtgggatgtg ggggccagga cagctcagct caggaaggcc 120
aatgaccaga gtggccgatg ccagtatacc ttcagtgtgg ccagtcccaa tgaatccagc 180
tgcccagagc agagccaggc catgtcagtc atccataact tacagagaga cagcagcacc 240
caacgcttag acctggaggc caccaaagct cgactcagct ccctggagag cctcctccac 300
caattgacct tggaccaggc tgccaggccc caggagaccc aggaggggct gcagagggag 360
ctgggcaccc tgaggcggga gcgggaccag ctggaaaccc aaaccagaga gttggagact 420
gcctacagca acctcctccg agacaagtca gttctggagg aagagaagaa gcgactaagg 480
caagaaaatg agaatctggc caggaggttg gaaagcagca gccaggaggt agcaaggctg 540
agaaggggcc agtgtcccca gacccgagac actgctcggg ctgtgccacc aggctccaga 600
gaagtttcta cgtggaattt ggacactttg gccttccagg aactgaagtc cgagctaact 660
gaagttcctg cttcccgaat tttgaaggag agcccatctg gctatctcag gagtggagag 720
ggagacaccg gatgtggaga actagtttgg gtaggagagc ctctcacgct gagaacagca 780
gaaacaatta ctggcaagta tggtgtgtgg atgcgagacc ccaagcccac ctacccctac 840
acccaggaga ccacgtggag aatcgacaca gttggcacgg atgtccgcca ggtttttgag 900
tatgacctca tcagccagtt tatgcagggc tacccttcta aggttcacat actgcctagg 960
ccactggaaa gcacgggtgc tgtggtgtac tcggggagcc tctatttcca gggcgctgag 1020
tccagaactg tcataagata tgagctgaat accgagacag tgaaggctga gaaggaaatc 1080
cctggagctg gctaccacgg acagttcccg tattcttggg gtggctacac ggacattgac 1140
ttggctgtgg atgaagcagg cctctgggtc atttacagca ccgatgaggc caaaggtgcc 1200
attgtcctct ccaaactgaa cccagagaat ctggaactcg aacaaacctg ggagacaaac 1260
atccgtaagc agtcagtcgc caatgccttc atcatctgtg gcaccttgta caccgtcagc 1320
agctacacct cagcagatgc taccgtcaac tttgcttatg acacaggcac aggtatcagc 1380
aagaccctga ccatcccatt caagaaccgc tataagtaca gcagcatgat tgactacaac 1440
cccctggaga agaagctctt tgcctgggac aacttgaaca tggtcactta tgacatcaag 1500
ctctccaaga tgtag                                                  1515

<210> 5
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
ggccatgtca gtcatccat                                              19

<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Gln Ala Met Ser Val Ile His
 1               5          


<210> 7
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
aatagtgaag ccacagatgt att                                         23

<210> 8
<211> 259
<212> PRT
<213> Homo sapiens

<400> 8
Met Arg Leu Gly Leu Cys Val Val Val Leu Ser Trp Thr His Leu Thr
 1               5                  10                  15      
Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile Ser Ala
            20                  25                  30          
Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val
        35                  40                  45              
Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg
    50                  55                  60                  
Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly
65                  70                  75                  80  
Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys
                85                  90                  95      
Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys
            100                 105                 110         
Lys Glu Gly Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly
        115                 120                 125             
Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro Ala Gln Cys
    130                 135                 140                 
Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys Lys Gln Gln
145                 150                 155                 160 
Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg Arg Val Leu
                165                 170                 175     
His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr Lys Glu Thr
            180                 185                 190         
Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu Gly Gln Lys Arg
        195                 200                 205             
Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn Arg Asn Leu Ala
    210                 215                 220                 
Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg Arg Arg Lys Gly
225                 230                 235                 240 
Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly Pro Leu Thr Ser Ala
                245                 250                 255     
Gly Pro Ala
            


<210> 9
<211> 243
<212> PRT
<213> Homo sapiens

<400> 9
Met Gln Phe Arg Leu Phe Ser Phe Ala Leu Ile Ile Leu Asn Cys Met
 1               5                  10                  15      
Asp Tyr Ser His Cys Gln Gly Asn Arg Trp Arg Arg Ser Lys Arg Ala
            20                  25                  30          
Ser Tyr Val Ser Asn Pro Ile Cys Lys Gly Cys Leu Ser Cys Ser Lys
        35                  40                  45              
Asp Asn Gly Cys Ser Arg Cys Gln Gln Lys Leu Phe Phe Phe Leu Arg
    50                  55                  60                  
Arg Glu Gly Met Arg Gln Tyr Gly Glu Cys Leu His Ser Cys Pro Ser
65                  70                  75                  80  
Gly Tyr Tyr Gly His Arg Ala Pro Asp Met Asn Arg Cys Ala Arg Cys
                85                  90                  95      
Arg Ile Glu Asn Cys Asp Ser Cys Phe Ser Lys Asp Phe Cys Thr Lys
            100                 105                 110         
Cys Lys Val Gly Phe Tyr Leu His Arg Gly Arg Cys Phe Asp Glu Cys
        115                 120                 125             
Pro Asp Gly Phe Ala Pro Leu Glu Glu Thr Met Glu Cys Val Glu Gly
    130                 135                 140                 
Cys Glu Val Gly His Trp Ser Glu Trp Gly Thr Cys Ser Arg Asn Asn
145                 150                 155                 160 
Arg Thr Cys Gly Phe Lys Trp Gly Leu Glu Thr Arg Thr Arg Gln Ile
                165                 170                 175     
Val Lys Lys Pro Val Lys Asp Thr Ile Leu Cys Pro Thr Ile Ala Glu
            180                 185                 190         
Ser Arg Arg Cys Lys Met Thr Met Arg His Cys Pro Gly Gly Lys Arg
        195                 200                 205             
Thr Pro Lys Ala Lys Glu Lys Arg Asn Lys Lys Lys Lys Arg Lys Leu
    210                 215                 220                 
Ile Glu Arg Ala Gln Glu Gln His Ser Val Phe Leu Ala Thr Asp Arg
225                 230                 235                 240 
Ala Asn Gln
            


<210> 10
<211> 234
<212> PRT
<213> Homo sapiens

<400> 10
Met Arg Ala Pro Leu Cys Leu Leu Leu Leu Val Ala His Ala Val Asp
 1               5                  10                  15      
Met Leu Ala Leu Asn Arg Arg Lys Lys Gln Val Gly Thr Gly Leu Gly
            20                  25                  30          
Gly Asn Cys Thr Gly Cys Ile Ile Cys Ser Glu Glu Asn Gly Cys Ser
        35                  40                  45              
Thr Cys Gln Gln Arg Leu Phe Leu Phe Ile Arg Arg Glu Gly Ile Arg
    50                  55                  60                  
Gln Tyr Gly Lys Cys Leu His Asp Cys Pro Pro Gly Tyr Phe Gly Ile
65                  70                  75                  80  
Arg Gly Gln Glu Val Asn Arg Cys Lys Lys Cys Gly Ala Thr Cys Glu
                85                  90                  95      
Ser Cys Phe Ser Gln Asp Phe Cys Ile Arg Cys Lys Arg Gln Phe Tyr
            100                 105                 110         
Leu Tyr Lys Gly Lys Cys Leu Pro Thr Cys Pro Pro Gly Thr Leu Ala
        115                 120                 125             
His Gln Asn Thr Arg Glu Cys Gln Gly Glu Cys Glu Leu Gly Pro Trp
    130                 135                 140                 
Gly Gly Trp Ser Pro Cys Thr His Asn Gly Lys Thr Cys Gly Ser Ala
145                 150                 155                 160 
Trp Gly Leu Glu Ser Arg Val Arg Glu Ala Gly Arg Ala Gly His Glu
                165                 170                 175     
Glu Ala Ala Thr Cys Gln Val Leu Ser Glu Ser Arg Lys Cys Pro Ile
            180                 185                 190         
Gln Arg Pro Cys Pro Gly Glu Arg Ser Pro Gly Gln Lys Lys Gly Arg
        195                 200                 205             
Lys Asp Arg Arg Pro Arg Lys Asp Arg Lys Leu Asp Arg Arg Leu Asp
    210                 215                 220                 
Val Arg Pro Arg Gln Pro Gly Leu Gln Pro
225                 230                 


<210> 11
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Met Arg Leu Gly Leu Cys Val Val Val Leu Ser Trp Thr His Leu Thr
 1               5                  10                  15      
Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile Ser Ala
            20                  25                  30          
Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val
        35                  40                  45              
Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg
    50                  55                  60                  
Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly
65                  70                  75                  80  
Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys
                85                  90                  95      
Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys
            100                 105                 110         
Lys Glu Gly Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly
        115                 120                 125             
Ser Ser Ala
    130     


<210> 12
<211> 202
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Met Arg Leu Gly Leu Cys Val Val Val Leu Ser Trp Thr His Leu Thr
 1               5                  10                  15      
Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile Ser Ala
            20                  25                  30          
Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val
        35                  40                  45              
Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg
    50                  55                  60                  
Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly
65                  70                  75                  80  
Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys
                85                  90                  95      
Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys
            100                 105                 110         
Lys Glu Gly Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly
        115                 120                 125             
Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro Ala Gln Cys
    130                 135                 140                 
Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys Lys Gln Gln
145                 150                 155                 160 
Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg Arg Val Leu
                165                 170                 175     
His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr Lys Glu Thr
            180                 185                 190         
Arg Arg Cys Thr Val Arg Arg Val Pro Cys
        195                 200         


<210> 13
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Met Gln Phe Arg Leu Phe Ser Phe Ala Leu Ile Ile Leu Asn Cys Met
 1               5                  10                  15      
Asp Tyr Ser His Cys Gln Gly Asn Arg Trp Arg Arg Ser Lys Arg Ala
            20                  25                  30          
Ser Tyr Val Ser Asn Pro Ile Cys Lys Gly Cys Leu Ser Cys Ser Lys
        35                  40                  45              
Asp Asn Gly Cys Ser Arg Cys Gln Gln Lys Leu Phe Phe Phe Leu Arg
    50                  55                  60                  
Arg Glu Gly Met Arg Gln Tyr Gly Glu Cys Leu His Ser Cys Pro Ser
65                  70                  75                  80  
Gly Tyr Tyr Gly His Arg Ala Pro Asp Met Asn Arg Cys Ala Arg Cys
                85                  90                  95      
Arg Ile Glu Asn Cys Asp Ser Cys Phe Ser Lys Asp Phe Cys Thr Lys
            100                 105                 110         
Cys Lys Val Gly Phe Tyr Leu His Arg Gly Arg Cys Phe Asp Glu Cys
        115                 120                 125             
Pro Asp Gly Phe Ala Pro
    130                 


<210> 14
<211> 203
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Met Gln Phe Arg Leu Phe Ser Phe Ala Leu Ile Ile Leu Asn Cys Met
 1               5                  10                  15      
Asp Tyr Ser His Cys Gln Gly Asn Arg Trp Arg Arg Ser Lys Arg Ala
            20                  25                  30          
Ser Tyr Val Ser Asn Pro Ile Cys Lys Gly Cys Leu Ser Cys Ser Lys
        35                  40                  45              
Asp Asn Gly Cys Ser Arg Cys Gln Gln Lys Leu Phe Phe Phe Leu Arg
    50                  55                  60                  
Arg Glu Gly Met Arg Gln Tyr Gly Glu Cys Leu His Ser Cys Pro Ser
65                  70                  75                  80  
Gly Tyr Tyr Gly His Arg Ala Pro Asp Met Asn Arg Cys Ala Arg Cys
                85                  90                  95      
Arg Ile Glu Asn Cys Asp Ser Cys Phe Ser Lys Asp Phe Cys Thr Lys
            100                 105                 110         
Cys Lys Val Gly Phe Tyr Leu His Arg Gly Arg Cys Phe Asp Glu Cys
        115                 120                 125             
Pro Asp Gly Phe Ala Pro Leu Glu Glu Thr Met Glu Cys Val Glu Gly
    130                 135                 140                 
Cys Glu Val Gly His Trp Ser Glu Trp Gly Thr Cys Ser Arg Asn Asn
145                 150                 155                 160 
Arg Thr Cys Gly Phe Lys Trp Gly Leu Glu Thr Arg Thr Arg Gln Ile
                165                 170                 175     
Val Lys Lys Pro Val Lys Asp Thr Ile Leu Cys Pro Thr Ile Ala Glu
            180                 185                 190         
Ser Arg Arg Cys Lys Met Thr Met Arg His Cys
        195                 200             


<210> 15
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Met His Leu Arg Leu Ile Ser Trp Leu Phe Ile Ile Leu Asn Phe Met
 1               5                  10                  15      
Glu Tyr Ile Gly Ser Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg
            20                  25                  30          
Met His Pro Asn Val Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys
        35                  40                  45              
Ser Asp Tyr Asn Gly Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala
    50                  55                  60                  
Leu Glu Arg Ile Gly Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys
65                  70                  75                  80  
Pro Ser Gly Tyr Tyr Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr
                85                  90                  95      
Lys Cys Lys Ala Asp Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr
            100                 105                 110         
Lys Cys Lys Ser Gly Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn
        115                 120                 125             
Cys Pro Glu Gly Leu Glu Ala
    130                 135 


<210> 16
<211> 146
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Met His Leu Arg Leu Ile Ser Trp Leu Phe Ile Ile Leu Asn Phe Met
 1               5                  10                  15      
Glu Tyr Ile Gly Ser Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg
            20                  25                  30          
Met His Pro Asn Val Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys
        35                  40                  45              
Ser Asp Tyr Asn Gly Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala
    50                  55                  60                  
Leu Glu Arg Ile Gly Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys
65                  70                  75                  80  
Pro Ser Gly Tyr Tyr Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr
                85                  90                  95      
Lys Cys Lys Ala Asp Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr
            100                 105                 110         
Lys Cys Lys Ser Gly Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn
        115                 120                 125             
Cys Pro Glu Gly Leu Glu Ala Asn Asn His Thr Met Glu Cys Val Ser
    130                 135                 140                 
Ile Val
145     


<210> 17
<211> 206
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Met His Leu Arg Leu Ile Ser Trp Leu Phe Ile Ile Leu Asn Phe Met
 1               5                  10                  15      
Glu Tyr Ile Gly Ser Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg
            20                  25                  30          
Met His Pro Asn Val Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys
        35                  40                  45              
Ser Asp Tyr Asn Gly Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala
    50                  55                  60                  
Leu Glu Arg Ile Gly Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys
65                  70                  75                  80  
Pro Ser Gly Tyr Tyr Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr
                85                  90                  95      
Lys Cys Lys Ala Asp Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr
            100                 105                 110         
Lys Cys Lys Ser Gly Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn
        115                 120                 125             
Cys Pro Glu Gly Leu Glu Ala Asn Asn His Thr Met Glu Cys Val Ser
    130                 135                 140                 
Ile Val His Cys Glu Val Ser Glu Trp Asn Pro Trp Ser Pro Cys Thr
145                 150                 155                 160 
Lys Lys Gly Lys Thr Cys Gly Phe Lys Arg Gly Thr Glu Thr Arg Val
                165                 170                 175     
Arg Glu Ile Ile Gln His Pro Ser Ala Lys Gly Asn Leu Cys Pro Pro
            180                 185                 190         
Thr Asn Glu Thr Arg Lys Cys Thr Val Gln Arg Lys Lys Cys
        195                 200                 205     


<210> 18
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Met Arg Ala Pro Leu Cys Leu Leu Leu Leu Val Ala His Ala Val Asp
 1               5                  10                  15      
Met Leu Ala Leu Asn Arg Arg Lys Lys Gln Val Gly Thr Gly Leu Gly
            20                  25                  30          
Gly Asn Cys Thr Gly Cys Ile Ile Cys Ser Glu Glu Asn Gly Cys Ser
        35                  40                  45              
Thr Cys Gln Gln Arg Leu Phe Leu Phe Ile Arg Arg Glu Gly Ile Arg
    50                  55                  60                  
Gln Tyr Gly Lys Cys Leu His Asp Cys Pro Pro Gly Tyr Phe Gly Ile
65                  70                  75                  80  
Arg Gly Gln Glu Val Asn Arg Cys Lys Lys Cys Gly Ala Thr Cys Glu
                85                  90                  95      
Ser Cys Phe Ser Gln Asp Phe Cys Ile Arg Cys Lys Arg Gln Phe Tyr
            100                 105                 110         
Leu Tyr Lys Gly Lys Cys Leu Pro Thr Cys Pro Pro Gly Thr Leu Ala
        115                 120                 125             


<210> 19
<211> 195
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Met Arg Ala Pro Leu Cys Leu Leu Leu Leu Val Ala His Ala Val Asp
 1               5                  10                  15      
Met Leu Ala Leu Asn Arg Arg Lys Lys Gln Val Gly Thr Gly Leu Gly
            20                  25                  30          
Gly Asn Cys Thr Gly Cys Ile Ile Cys Ser Glu Glu Asn Gly Cys Ser
        35                  40                  45              
Thr Cys Gln Gln Arg Leu Phe Leu Phe Ile Arg Arg Glu Gly Ile Arg
    50                  55                  60                  
Gln Tyr Gly Lys Cys Leu His Asp Cys Pro Pro Gly Tyr Phe Gly Ile
65                  70                  75                  80  
Arg Gly Gln Glu Val Asn Arg Cys Lys Lys Cys Gly Ala Thr Cys Glu
                85                  90                  95      
Ser Cys Phe Ser Gln Asp Phe Cys Ile Arg Cys Lys Arg Gln Phe Tyr
            100                 105                 110         
Leu Tyr Lys Gly Lys Cys Leu Pro Thr Cys Pro Pro Gly Thr Leu Ala
        115                 120                 125             
His Gln Asn Thr Arg Glu Cys Gln Gly Glu Cys Glu Leu Gly Pro Trp
    130                 135                 140                 
Gly Gly Trp Ser Pro Cys Thr His Asn Gly Lys Thr Cys Gly Ser Ala
145                 150                 155                 160 
Trp Gly Leu Glu Ser Arg Val Arg Glu Ala Gly Arg Ala Gly His Glu
                165                 170                 175     
Glu Ala Ala Thr Cys Gln Val Leu Ser Glu Ser Arg Lys Cys Pro Ile
            180                 185                 190         
Gln Arg Pro
        195 


<210> 20
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccacgc 60
ccgggctttg cccgggcg                                               78

<210> 21
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
accacggaca gttcctgtat tcttggggtg g                                31

<210> 22
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
ccaccccaag aatacaggaa ctgtccgtgg t                                31

<210> 23
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
tctgtggcac cttgcacacc gtcagcagc                                   29

<210> 24
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
gctgctgacg gtgtgcaagg tgccacaga                                   29
