
                                SEQUENCE LISTING

<110> Regeneron Pharmaceuticals, Inc.
      Haruka Okamoto
      Jesper Gromada

<120> Anti-Glucagon Antibodies and Uses
  Thereof

<130> A0010WO01

<150> 62/050,889          
<151> 2014-09-16  

<160> 163

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 1
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt cgccttcagt aactatggca tgcactgggt ccgccaggct 120
ccaggcaagg ggctggaatg ggtgacattt atatcatatg atggaagtaa taaatactat 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaagtga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagaagca 300
gtattagctg ccctctttga ctactggggc cagggaaccc tggtcaccgt ctcctca    357

<210> 2
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 2
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asn Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Thr Phe Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ala Val Leu Ala Ala Leu Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 3
ggattcgcct tcagtaacta tggc                                        24

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 4
Gly Phe Ala Phe Ser Asn Tyr Gly
 1               5              


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 5
atatcatatg atggaagtaa taaa                                        24

<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 6
Ile Ser Tyr Asp Gly Ser Asn Lys
 1               5              


<210> 7
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 7
gcgaaagaag cagtattagc tgccctcttt gactac                           36

<210> 8
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 8
Ala Lys Glu Ala Val Leu Ala Ala Leu Phe Asp Tyr
 1               5                  10          


<210> 9
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 9
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaatcagaa ctacttagct 120
tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240
atcaacagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact 300
cctacgttcg gccaagggac caaggtggaa atcaaa                           336

<210> 10
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 10
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Asn Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Ser Thr Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105                 110         


<210> 11
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 11
cagagtgttt tatacagctc caacaatcag aactac                           36

<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 12
Gln Ser Val Leu Tyr Ser Ser Asn Asn Gln Asn Tyr
 1               5                  10          


<210> 13
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 13
tgggcatct                                                         9

<210> 14
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 14
Trp Ala Ser
 1          


<210> 15
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 15
cagcaatatt atagtactcc tacg                                        24

<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 16
Gln Gln Tyr Tyr Ser Thr Pro Thr
 1               5              


<210> 17
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 17
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt cacgttcaat acctatggca tgcactgggt ccgccaggct 120
ccagtcaagg ggctggagtg ggtggcattt atatcaaatg ataagagtaa tacattctat 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgttt 240
ctggaaatga acagcctgac agctgaggac acggctgttt attactgtgc gaaagagtcc 300
attttagcag ccctctttga ctactggggc cagggaaccc tggtcactgt ctcctca    357

<210> 18
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 18
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Phe Ile Ser Asn Asp Lys Ser Asn Thr Phe Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Glu Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 19
ggattcacgt tcaataccta tggc                                        24

<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 20
Gly Phe Thr Phe Asn Thr Tyr Gly
 1               5              


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 21
atatcaaatg ataagagtaa taca                                        24

<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 22
Ile Ser Asn Asp Lys Ser Asn Thr
 1               5              


<210> 23
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 23
gcgaaagagt ccattttagc agccctcttt gactac                           36

<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 24
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr
 1               5                  10          


<210> 25
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 25
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ttacttagct 120
tggtaccaac agaaaccaag acagcctctt aaactactca tttactgggc atctattcgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240
atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaatt ttatagtgtt 300
cccacttttg gccaggggac caagctggag atcaaa                           336

<210> 26
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 26
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Arg Gln
        35                  40                  45              
Pro Leu Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Phe Tyr Ser Val Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 27
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 27
cagagtgttt tatacagctc caacaataag aattac                           36

<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 28
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 29
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 29
tgggcatct                                                         9

<210> 30
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 30
Trp Ala Ser
 1          


<210> 31
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 31
cagcaatttt atagtgttcc cact                                        24

<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 32
Gln Gln Phe Tyr Ser Val Pro Thr
 1               5              


<210> 33
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 33
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt cacgtttagt acctttggca tgcactgggt ccgccaggct 120
ccagtcaagg ggctggagtg ggtggctttt atatcaaatg ataagaataa taaattctat 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaggga cacgctatat 240
ctgcaaatga acagcctgac acctgaggac acggctgttt attactgtgc gaaagagtcc 300
attttagcag ccctctttga ctactggggc cagggaaccc tggtcaccgt ctcctca    357

<210> 34
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 34
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Phe
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Phe Ile Ser Asn Asp Lys Asn Asn Lys Phe Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asp Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 35
ggattcacgt ttagtacctt tggc                                        24

<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 36
Gly Phe Thr Phe Ser Thr Phe Gly
 1               5              


<210> 37
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 37
atatcaaatg ataagaataa taaa                                        24

<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 38
Ile Ser Asn Asp Lys Asn Asn Lys
 1               5              


<210> 39
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 39
gcgaaagagt ccattttagc agccctcttt gactac                           36

<210> 40
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 40
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr
 1               5                  10          


<210> 41
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 41
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaataaaaa ttacttagct 120
tggtaccagc agaaaccagg acagcctctt aaacttctca tttactgggc atctattcgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240
atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaatt ttatactgtt 300
cccacttttg gcctggggac caagctggag atcaaa                           336

<210> 42
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 42
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Leu Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Phe Tyr Thr Val Pro Thr Phe Gly Leu Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 43
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 43
cagagtgttt tatacagctc caacaataaa aattac                           36

<210> 44
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 44
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 45
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 45
tgggcatct                                                         9

<210> 46
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 46
Trp Ala Ser
 1          


<210> 47
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 47
cagcaatttt atactgttcc cact                                        24

<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 48
Gln Gln Phe Tyr Thr Val Pro Thr
 1               5              


<210> 49
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 49
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgtag cctctggatt caccttcagg aactatgaca tgcactgggt ccgccaggct 120
cctggcaagg ggctggaatg ggtggcagtt acatcatctg atggacttaa taaattctat 180
tcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtct 240
ctgcaaatta ccggcctgag agctgaggac acggctgtgt attactgtgc gaaagagtcc 300
attttagcag ccctctttga ctactggggc cagggaaccc tggtcaccgt ctcctca    357

<210> 50
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 50
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asn Tyr
            20                  25                  30          
Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Thr Ser Ser Asp Gly Leu Asn Lys Phe Tyr Ser Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser
65                  70                  75                  80  
Leu Gln Ile Thr Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 51
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 51
ggattcacct tcaggaacta tgac                                        24

<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 52
Gly Phe Thr Phe Arg Asn Tyr Asp
 1               5              


<210> 53
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 53
acatcatctg atggacttaa taaa                                        24

<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 54
Thr Ser Ser Asp Gly Leu Asn Lys
 1               5              


<210> 55
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 55
gcgaaagagt ccattttagc agccctcttt gactac                           36

<210> 56
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 56
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr
 1               5                  10          


<210> 57
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 57
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttggct 120
tggtaccagc agaaaccagg acagcctcct aagctgctct tttactgggc atctacccgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240
atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaaca ttatactact 300
cccacttttg gccaggggac caagctggag atcaaa                           336

<210> 58
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 58
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Phe Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
His Tyr Thr Thr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 59
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 59
cagagtgttt tatacagctc caacaataag aactac                           36

<210> 60
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 60
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 61
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 61
tgggcatct                                                         9

<210> 62
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 62
Trp Ala Ser
 1          


<210> 63
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 63
cagcaacatt atactactcc cact                                        24

<210> 64
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 64
Gln Gln His Tyr Thr Thr Pro Thr
 1               5              


<210> 65
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 65
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccagact 120
ccgggcaagg ggctggagtg ggtggcattt atatcatatg atggaaataa taaatactat 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgttt 240
ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagagtcc 300
attttagcag ccctctttga ctactggggc cagggaaccc tggtcaccgt ctcctca    357

<210> 66
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 66
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 67
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 67
ggattcacct tcagtagcta tggc                                        24

<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 68
Gly Phe Thr Phe Ser Ser Tyr Gly
 1               5              


<210> 69
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 69
atatcatatg atggaaataa taaa                                        24

<210> 70
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 70
Ile Ser Tyr Asp Gly Asn Asn Lys
 1               5              


<210> 71
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 71
gcgaaagagt ccattttagc agccctcttt gactac                           36

<210> 72
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 72
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr
 1               5                  10          


<210> 73
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 73
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct 120
tggtaccagc agaaacctgg acagcctcct aagctgctca tttactgggc atctacccgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240
atcagcagcc tgcaggctga agatgtggca ctttattact gtcaacaata ttataatact 300
cccacttttg gccaggggac caagctggag atcaaa                           336

<210> 74
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 74
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Leu Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Asn Thr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 75
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 75
cagagtgttt tatacagctc caacaataag aactac                           36

<210> 76
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 76
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 77
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 77
tgggcatct                                                         9

<210> 78
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 78
Trp Ala Ser
 1          


<210> 79
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 79
caacaatatt ataatactcc cact                                        24

<210> 80
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 80
Gln Gln Tyr Tyr Asn Thr Pro Thr
 1               5              


<210> 81
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 81
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct 120
ccagtcaagg ggctggagtg ggtggcattt atatcatatg atggaagtaa taaatactat 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctccaaatga acagcctgac agctgaggac acggctgttt attactgtgc gaaagagtcc 300
attttagcag ccctctttga ctactggggc cagggaaccc tggtcaccgt ctcctca    357

<210> 82
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 82
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Phe Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 83
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 83
ggattcacct tcagtagcta tggc                                        24

<210> 84
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 84
Gly Phe Thr Phe Ser Ser Tyr Gly
 1               5              


<210> 85
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 85
atatcatatg atggaagtaa taaa                                        24

<210> 86
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 86
Ile Ser Tyr Asp Gly Ser Asn Lys
 1               5              


<210> 87
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 87
gcgaaagagt ccattttagc agccctcttt gactac                           36

<210> 88
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 88
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr
 1               5                  10          


<210> 89
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 89
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagttcca acaataagaa ctacttagct 120
tggtaccagc agaaaccaag acagcctcct aagctgctca tttactgggc atctattcgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cattctcacc 240
atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaatt ttatagtatt 300
cccacttttg gccaggggac caagctggag atcaaa                           336

<210> 90
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 90
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Arg Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Phe Tyr Ser Ile Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 91
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 91
cagagtgttt tatacagttc caacaataag aactac                           36

<210> 92
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 92
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 93
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 93
tgggcatct                                                         9

<210> 94
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 94
Trp Ala Ser
 1          


<210> 95
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 95
cagcaatttt atagtattcc cact                                        24

<210> 96
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 96
Gln Gln Phe Tyr Ser Ile Pro Thr
 1               5              


<210> 97
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 97
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttagt agctatggca tgcactgggt ccgccaggct 120
ccagtcaagg ggctggagtg ggtggcattt atatcaaatg ataaaagtaa taaatattat 180
gcagactcct tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgac agctgaagac acggctgttt attactgtgc gaaagagtcc 300
attttagcag ccctctttga ctattggggc cagggaaccc tggtcaccgt ctcctca    357

<210> 98
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 98
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Phe Ile Ser Asn Asp Lys Ser Asn Lys Tyr Tyr Ala Asp Ser Leu
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 99
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 99
ggattcacct ttagtagcta tggc                                        24

<210> 100
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 100
Gly Phe Thr Phe Ser Ser Tyr Gly
 1               5              


<210> 101
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 101
atatcaaatg ataaaagtaa taaa                                        24

<210> 102
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 102
Ile Ser Asn Asp Lys Ser Asn Lys
 1               5              


<210> 103
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 103
gcgaaagagt ccattttagc agccctcttt gactat                           36

<210> 104
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 104
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr
 1               5                  10          


<210> 105
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 105
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct 120
tggtaccagc agaaaccaag acagcctcct aagctactca tttactgggc atctattcgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240
atcagcagcc tgcaggctga agatgtggca gtttattact gtcaacaatt ttatagtgtt 300
cccacttttg gccaggggac caagctggag atcaaa                           336

<210> 106
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 106
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Arg Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Phe Tyr Ser Val Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 107
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 107
cagagtgttt tatacagctc caacaataag aactac                           36

<210> 108
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 108
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 109
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 109
tgggcatct                                                         9

<210> 110
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 110
Trp Ala Ser
 1          


<210> 111
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 111
caacaatttt atagtgttcc cact                                        24

<210> 112
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 112
Gln Gln Phe Tyr Ser Val Pro Thr
 1               5              


<210> 113
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 113
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct 120
ccagtcaagg ggctggagtg ggtggcattt atatcatttg atggaagtaa taaatactat 180
acagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctccaaatga acagcctgac agctgaggac acggctattt attactgtgc gaaagagtcc 300
attttagcag ccctctttga ctactggggc cagggaaccc tggtcactgt ctcctca    357

<210> 114
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 114
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Phe Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Thr Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 115
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 115
ggattcacct tcagtagcta tggc                                        24

<210> 116
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 116
Gly Phe Thr Phe Ser Ser Tyr Gly
 1               5              


<210> 117
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 117
atatcatttg atggaagtaa taaa                                        24

<210> 118
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 118
Ile Ser Phe Asp Gly Ser Asn Lys
 1               5              


<210> 119
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 119
gcgaaagagt ccattttagc agccctcttt gactac                           36

<210> 120
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 120
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr
 1               5                  10          


<210> 121
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 121
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct 120
tggtaccagc agaaaccaag acagcctcct aacctgctca tttactgggc atctattcgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240
atcagcagcc tgcaggctga agatgtggca ttttattact gtcagcaatt ttatagtatt 300
cccacttttg gccaggggac caagctggag atcaaa                           336

<210> 122
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 122
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Arg Gln
        35                  40                  45              
Pro Pro Asn Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Phe Tyr Tyr Cys Gln Gln
                85                  90                  95      
Phe Tyr Ser Ile Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 123
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 123
cagagtgttt tatacagctc caacaataag aactac                           36

<210> 124
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 124
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 125
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 125
tgggcatct                                                         9

<210> 126
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 126
Trp Ala Ser
 1          


<210> 127
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 127
cagcaatttt atagtattcc cact                                        24

<210> 128
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 128
Gln Gln Phe Tyr Ser Ile Pro Thr
 1               5              


<210> 129
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 129
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttagg acctatggca tgcactgggt ccgccaggct 120
ccagtcaagg ggctggagtg ggtggcattt atatcaaagg atggaagtga taaatactat 180
gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgttt 240
ctgcaaatga acagcctgac agctgaggac acggctgttt attattgtgc gaaagagtcc 300
attttagcag ccctctttga ctactggggc cagggaaccc tggtcactgt ctcctca    357

<210> 130
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 130
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Phe Ile Ser Lys Asp Gly Ser Asp Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 131
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 131
ggattcacct ttaggaccta tggc                                        24

<210> 132
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 132
Gly Phe Thr Phe Arg Thr Tyr Gly
 1               5              


<210> 133
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 133
atatcaaagg atggaagtga taaa                                        24

<210> 134
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 134
Ile Ser Lys Asp Gly Ser Asp Lys
 1               5              


<210> 135
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 135
gcgaaagagt ccattttagc agccctcttt gactac                           36

<210> 136
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 136
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Tyr
 1               5                  10          


<210> 137
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 137
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct 120
tggtaccagc agaaaccaag acagcctcct aaactcctca tttactgggc atctaatcgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240
atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaatt ttatagtgtt 300
cccacttttg gccaggggac caagctggag atcaaa                           336

<210> 138
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 138
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Arg Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Asn Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Phe Tyr Ser Val Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 139
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 139
cagagtgttt tatacagctc caacaataag aactac                           36

<210> 140
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 140
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 141
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 141
tgggcatct                                                         9

<210> 142
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 142
Trp Ala Ser
 1          


<210> 143
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 143
cagcaatttt atagtgttcc cact                                        24

<210> 144
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 144
Gln Gln Phe Tyr Ser Val Pro Thr
 1               5              


<210> 145
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 145
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttagt agctatggca tgcactgggt ccgccaggct 120
ccagtcaagg ggctggagtg ggtggcattt atatcaaatg ataaaagtaa taaatactat 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgac agctgaggac acggctgttt attactgtgc gaaagagtcc 300
attttagcag ccctctttga ctcctggggc cagggaaccc tggtcaccgt ctcctca    357

<210> 146
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 146
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Phe Ile Ser Asn Asp Lys Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Ser Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 147
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 147
ggattcacct ttagtagcta tggc                                        24

<210> 148
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 148
Gly Phe Thr Phe Ser Ser Tyr Gly
 1               5              


<210> 149
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 149
atatcaaatg ataaaagtaa taaa                                        24

<210> 150
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 150
Ile Ser Asn Asp Lys Ser Asn Lys
 1               5              


<210> 151
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 151
gcgaaagagt ccattttagc agccctcttt gactcc                           36

<210> 152
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 152
Ala Lys Glu Ser Ile Leu Ala Ala Leu Phe Asp Ser
 1               5                  10          


<210> 153
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 153
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct 120
tggtaccagc agaaaccaag acagcctcct aagctgctca tttactgggc atctattcgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg gggcagattt cactctcacc 240
atcagcagcc tgcaggctgc agatgtggca gtttattact gtcagcaatt ttatagtgtt 300
cccacttttg gccaggggac caagctggag atcaaa                           336

<210> 154
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 154
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Arg Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Ala Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Phe Tyr Ser Val Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 155
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 155
cagagtgttt tatacagctc caacaataag aactac                           36

<210> 156
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 156
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 157
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 157
tgggcatct                                                         9

<210> 158
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 158
Trp Ala Ser
 1          


<210> 159
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 159
cagcaatttt atagtgttcc cact                                        24

<210> 160
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic
      

<400> 160
Gln Gln Phe Tyr Ser Val Pro Thr
 1               5              


<210> 161
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> GCG mature peptide: aa 53-81 of NP_002045.1
      

<400> 161
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
 1               5                  10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr
            20                  25                  


<210> 162
<211> 2076
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCSK9 DNA
      

<400> 162
datgggcacc gtcagctcca ggcggtcctg gtggccgctg ccactgctgc tgctgctgct 60
gctgctcctg ggtcccgcgg gcgcccgtgc gcaggaggac gaggacggcg actacgagga 120
gctggtgcta gccttgcgtt ccgaggagga cggcctggcc gaagcacccg agcacggaac 180
cacagccacc ttccaccgct gcgccaagga tccgtggagg ttgcctggca cctacgtggt 240
ggtgctgaag gaggagaccc acctctcgca gtcagagcgc actgcccgcc gcctgcaggc 300
ccaggctgcc cgccggggat acctcaccaa gatcctgcat gtcttccatg gccttcttcc 360
tggcttcctg gtgaagatga gtggcgacct gctggagctg gccttgaagt tgccccatgt 420
cgactacatc gaggaggact cctctgtctt tgcccagagc atcccgtgga acctggagcg 480
gattacccct ccacggtacc gggcggatga ataccagccc cccgacggag gcagcctggt 540
ggaggtgtat ctcctagaca ccagcataca gagtgaccac cgggaaatcg agggcagggt 600
catggtcacc gacttcgaga atgtgcccga ggaggacggg acccgcttcc acagacaggc 660
cagcaagtgt gacagtcatg gcacccacct ggcaggggtg gtcagcggcc gggatgccgg 720
cgtggccaag ggtgccagca tgcgcagcct gcgcgtgctc aactgccaag ggaagggcac 780
ggttagcggc accctcatag gcctggagtt tattcggaaa agccagctgg tccagcctgt 840
ggggccactg gtggtgctgc tgcccctggc gggtgggtac agccgcgtcc caacgccgcc 900
tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac 960
gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat 1020
gcccaggacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac 1080
ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg 1140
tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg 1200
tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc 1260
aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg 1320
gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgtg 1380
tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat 1440
gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg 1500
gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc 1560
tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca 1620
ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca 1680
ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg 1740
ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc 1800
tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag 1860
caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg 1920
acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac 1980
gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg 2040
agccggcacc tggcgcaggc ctcccaggag ctccag                           2076

<210> 163
<211> 693
<212> PRT
<213> Artificial Sequence

<220> 
<223> PCSK9 aa
      

<400> 163
Pro Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln
            20                  25                  30          
Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser
        35                  40                  45              
Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr
    50                  55                  60                  
Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val
65                  70                  75                  80  
Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala
                85                  90                  95      
Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile
            100                 105                 110         
Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser
        115                 120                 125             
Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile
    130                 135                 140                 
Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu
145                 150                 155                 160 
Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp
                165                 170                 175     
Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser
            180                 185                 190         
Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn
        195                 200                 205             
Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys
    210                 215                 220                 
Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala
225                 230                 235                 240 
Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys
                245                 250                 255     
Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile
            260                 265                 270         
Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu
        275                 280                 285             
Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg
    290                 295                 300                 
Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg
305                 310                 315                 320 
Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr
                325                 330                 335     
Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu
            340                 345                 350         
Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp
        355                 360                 365             
Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser
    370                 375                 380                 
Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met
385                 390                 395                 400 
Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu
                405                 410                 415     
Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu
            420                 425                 430         
Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser
        435                 440                 445             
Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala
    450                 455                 460                 
His Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro
465                 470                 475                 480 
Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg
                485                 490                 495     
Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala
            500                 505                 510         
His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys
        515                 520                 525             
Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu
    530                 535                 540                 
Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu
545                 550                 555                 560 
Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys
                565                 570                 575     
Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His
            580                 585                 590         
Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu
        595                 600                 605             
Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr
    610                 615                 620                 
Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro
625                 630                 635                 640 
Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val
                645                 650                 655     
Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala
            660                 665                 670         
Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala
        675                 680                 685             
Ser Gln Glu Leu Gln
    690             

