                               SEQUENCE LISTING

<110> TRUSTEES OF BOSTON UNIVERSITY
 
<120> THERAPEUTIC AND RESEARCH APPLICATION OF PDCL3

<130> 701586-082551-PCT

<140> PCT/US2015/050108
<141> 2015-09-15

<150> 62/050,375
<151> 2014-09-15

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 239
<212> PRT
<213> Homo sapiens

<400> 1
Met Gln Asp Pro Asn Ala Asp Thr Glu Trp Asn Asp Ile Leu Arg Lys 
1               5                   10                  15      


Lys Gly Ile Leu Pro Pro Lys Glu Ser Leu Lys Glu Leu Glu Glu Glu 
            20                  25                  30          


Ala Glu Glu Glu Gln Arg Ile Leu Gln Gln Ser Val Val Lys Thr Tyr 
        35                  40                  45              


Glu Asp Met Thr Leu Glu Glu Leu Glu Asp His Glu Asp Glu Phe Asn 
    50                  55                  60                  


Glu Glu Asp Glu Arg Ala Ile Glu Met Tyr Arg Arg Arg Arg Leu Ala 
65                  70                  75                  80  


Glu Trp Lys Ala Thr Lys Leu Lys Asn Lys Phe Gly Glu Val Leu Glu 
                85                  90                  95      


Ile Ser Gly Lys Asp Tyr Val Gln Glu Val Thr Lys Ala Gly Glu Gly 
            100                 105                 110         


Leu Trp Val Ile Leu His Leu Tyr Lys Gln Gly Ile Pro Leu Cys Ala 
        115                 120                 125             


Leu Ile Asn Gln His Leu Ser Gly Leu Ala Arg Lys Phe Pro Asp Val 
    130                 135                 140                 


Lys Phe Ile Lys Ala Ile Ser Thr Thr Cys Ile Pro Asn Tyr Pro Asp 
145                 150                 155                 160 


Arg Asn Leu Pro Thr Ile Phe Val Tyr Leu Glu Gly Asp Ile Lys Ala 
                165                 170                 175     


Gln Phe Ile Gly Pro Leu Val Phe Gly Gly Met Asn Leu Thr Arg Asp 
            180                 185                 190         


Glu Leu Glu Trp Lys Leu Ser Glu Ser Gly Ala Ile Met Thr Asp Leu 
        195                 200                 205             


Glu Glu Asn Pro Lys Lys Pro Ile Glu Asp Val Leu Leu Ser Ser Val 
    210                 215                 220                 


Arg Arg Ser Val Leu Met Lys Arg Asp Ser Asp Ser Glu Gly Asp 
225                 230                 235                 


<210> 2
<211> 1086
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
gaaggctggg ctgggggaag aggcgtggcg gcgctgtgcg cgtgcacaaa agagagctga       60

ggggcggggg cgctgcggca cagctggttt gagcaactga actggaaaca agatgcagga      120

ccccaacgca gacactgaat ggaatgacat cttacgcaaa aagggtatct taccccccaa      180

ggaaagtctg aaagaattgg aagaggaggc agaagaggag cagcgcatcc tccagcagtc      240

agtggtgaaa acatatgaag atatgacttt ggaagagctg gaggatcatg aagacgagtt      300

taatgaggag gatgaacgtg ctattgaaat gtacagacgg cggagactgg ctgagtggaa      360

agcaactaaa ctgaagaata aattcggaga agttttggag atctcaggga aggattatgt      420

tcaagaagtt accaaagctg gcgagggctt gtgggtcatc ttgcaccttt acaaacaagg      480

aattcccctc tgtgccctga taaatcagca cctcagtgga cttgccagga agtttcctga      540

tgtcaaattt atcaaagcca tttcaacaac ctgcataccc aattatcctg ataggaatct      600

gcccacgata tttgtttacc tggaaggaga tatcaaggct cagtttattg gtcctctggt      660

gtttggcggc atgaacctga caagagatga gttggaatgg aaactgtctg aatctggagc      720

aattatgaca gacctggagg aaaaccctaa gaagccgatt gaagacgtgt tgctgtcctc      780

agtgcggcgc tctgtcctca tgaagaggga cagcgattcc gagggtgact gaggctacag      840

cttctatcac atgccgaact ttcttgtgac aaattgtctg gattttttaa aaaaggaaaa      900

agcaagaatg aatccttgtg gtttttagtt ttgtataaat tatgtttcaa atctttacat      960

tttggaaata atcattgctg gagattctgt taaatatttt ggaactcttt ttttttttaa     1020

attatagtat ttcctctaaa aaaaattaaa accagccatt tgtatggcaa atgtcaaaaa     1080

aaaaaa                                                                1086


<210> 3
<211> 240
<212> PRT
<213> Mus musculus

<400> 3
Met Gln Asp Pro Asn Ala Asp Thr Glu Trp Asn Asp Ile Leu Arg Lys 
1               5                   10                  15      


Lys Gly Ile Leu Pro Pro Lys Glu Ser Leu Lys Glu Leu Glu Glu Glu 
            20                  25                  30          


Glu Ala Glu Lys Glu Glu Gln Leu Leu Gln Gln Ser Val Val Lys Thr 
        35                  40                  45              


Tyr Glu Asp Met Thr Leu Glu Glu Leu Glu Glu Asn Glu Asp Glu Phe 
    50                  55                  60                  


Ser Glu Glu Asp Glu Arg Ala Ile Glu Met Tyr Arg Gln Gln Arg Leu 
65                  70                  75                  80  


Ala Glu Trp Lys Ala Thr Gln Leu Lys Asn Lys Phe Gly Glu Val Leu 
                85                  90                  95      


Glu Ile Ser Gly Lys Asp Tyr Val Gln Glu Val Thr Lys Ala Gly Glu 
            100                 105                 110         


Gly Leu Trp Val Ile Leu His Leu Tyr Lys Gln Gly Ile Pro Leu Cys 
        115                 120                 125             


Ser Leu Ile Asn His His Leu Ser Gly Leu Ala Arg Lys Phe Pro Asp 
    130                 135                 140                 


Val Lys Phe Ile Lys Ala Ile Ser Thr Thr Cys Ile Pro Asn Tyr Pro 
145                 150                 155                 160 


Asp Arg Asn Leu Pro Thr Val Phe Val Tyr Arg Glu Gly Asp Ile Lys 
                165                 170                 175     


Ala Gln Phe Ile Gly Pro Leu Val Phe Gly Gly Met Asn Leu Thr Ile 
            180                 185                 190         


Asp Glu Leu Glu Trp Lys Leu Ser Glu Ser Gly Ala Ile Lys Thr Ala 
        195                 200                 205             


Leu Glu Glu Asn Pro Lys Lys Pro Ile Gln Asp Leu Leu Leu Ser Ser 
    210                 215                 220                 


Val Arg Gly Pro Val Pro Met Arg Arg Asp Ser Asp Ser Glu Asp Asp 
225                 230                 235                 240 


<210> 4
<211> 1706
<212> DNA
<213> Mus musculus

<400> 4
agagggctgg tttgagtgac tgaaggcaag atgcaggacc ccaatgcaga caccgagtgg       60

aatgacatcc tacgtaaaaa gggcatcctt cccccgaagg agagcctgaa ggagctggag      120

gaggaggagg cggagaagga ggagcagctc ctccagcagt cagtggtgaa aacatacgag      180

gacatgactc tggaagagct ggaggagaac gaggatgagt tcagtgagga ggatgaacga      240

gctatcgaga tgtaccggca acagaggttg gctgagtgga aagcaactca gctgaagaac      300

aaatttggag aagttttaga gatctcagga aaggactatg ttcaagaagt tacgaaagcc      360

ggcgagggcc tgtgggtgat cttacacctg tacaaacaag ggattcccct ctgttccttg      420

ataaaccatc acttgagtgg actcgccagg aagtttcccg atgtgaaatt tatcaaagcc      480

atttcaacga cctgcatacc caactacccc gacaggaatc tccccacggt gttcgtctac      540

cgggaagggg atatcaaggc acagttcatt ggtcctctgg tgttcggtgg catgaacctg      600

accatagacg agttggagtg gaaactgtct gagtcaggag cgatcaagac agccctggag      660

gagaacccca agaagcccat ccaggacctg ctgctgtcct cagtccgggg ccctgtcccc      720

atgaggaggg acagtgattc tgaggacgac taagatggca gtgatggaac ctttgaacct      780

tcttgatatg acgcattgtc tgggtttttt ataaggaggg aaaagcaaaa tgtatcattt      840

tggtttttaa cctttttata attatttaaa ttttatacat ttcggatata atcattgctg      900

aactttttta agaaatttgt tggaactctt taattaatca tgtttcttta agagaaattt      960

aagcaagctt gttatgtcac atatctatgt tttcctatgt gtatttcagg aaaccatgaa     1020

actgttcagt attttttgac atgtaactct atagaaagga atgtggactt aaaaaatata     1080

atgcgaataa atttaagtta aaatctctat aaaaaataac agtgcaaaaa atgagaactc     1140

agctttctag ttagatcgtt cgttttcctt ttgtaaagct agcaaaagga gtatcagcta     1200

aaagaaatgg ctgataattt tgagacagat actgatttat caaattagct gacagatttc     1260

agctcactgc catgtctgtt tgctttcagc ccagtcttcc aggtaaacta atgttctcta     1320

tggctgttaa gacaccagct attctttgta gtggcacatg cctttaatct cagcactggg     1380

agacaggggc aggcaggtca tgtgagatca aggccagtct ggtttgcata gttaccagct     1440

agccagggct gcgttaccaa gaccctgtct ccaaaccaag cagctcttct tggctgtaag     1500

gtcctgttag agttggtttg ggggaataag gtttaagcag atacatatat aagctctatc     1560

ccagtcgatt tgtaaaaata tttcaggata tcctgtaaag tgacaatgaa agccgaaaaa     1620

tatctataat atttttgttg aatgctatac cctgtatagc tgattggaat cttagagata     1680

agagtctaag aatacagggt ttactc                                          1706


<210> 5
<211> 240
<212> PRT
<213> Rattus norvegicus

<400> 5
Met Gln Asp Pro Asn Ala Asp Thr Glu Trp Asn Asp Ile Leu Arg Lys 
1               5                   10                  15      


Lys Gly Ile Leu Pro Pro Lys Glu Ser Leu Lys Glu Leu Glu Glu Glu 
            20                  25                  30          


Glu Glu Gly Lys Glu Glu Gln Arg Leu Gln Gln Ser Val Val Lys Thr 
        35                  40                  45              


Tyr Glu Asp Met Thr Leu Glu Glu Leu Gln Glu Asn Glu Asp Glu Phe 
    50                  55                  60                  


Ser Glu Glu Asp Glu Arg Ala Ile Glu Met Tyr Arg Gln Gln Arg Leu 
65                  70                  75                  80  


Ala Glu Trp Lys Ala Thr Gln Leu Arg Asn Lys Phe Gly Glu Val Leu 
                85                  90                  95      


Glu Ile Ser Gly Lys Asp Tyr Val Gln Glu Val Thr Lys Ala Gly Glu 
            100                 105                 110         


Gly Leu Trp Val Val Leu His Leu Tyr Lys Gln Gly Ile Pro Leu Cys 
        115                 120                 125             


Ser Leu Ile Asn His His Leu Ser Gly Leu Ala Arg Lys Phe Pro Asp 
    130                 135                 140                 


Val Lys Phe Ile Lys Ala Ile Ser Thr Thr Cys Ile Pro Asn Tyr Pro 
145                 150                 155                 160 


Asp Arg Asn Leu Pro Thr Val Phe Val Tyr Arg Glu Gly Asp Ile Lys 
                165                 170                 175     


Ala Gln Phe Ile Gly Pro Leu Val Phe Gly Gly Met Asn Leu Thr Ile 
            180                 185                 190         


Asp Glu Leu Glu Trp Lys Leu Ser Glu Ser Gly Ala Ile Lys Thr Glu 
        195                 200                 205             


Leu Glu Glu Asn Pro Lys Lys Ala Ile Lys Asp Val Leu Leu Ser Ser 
    210                 215                 220                 


Val Arg Asp Pro Val Pro Met Arg Arg Asp Ser Asp Ser Glu Asp Asp 
225                 230                 235                 240 


<210> 6
<211> 1784
<212> DNA
<213> Rattus norvegicus

<400> 6
ccgaaggggc ggtgctacaa ggcgccagag gagcggaggc tggggcctag gggctggtcg       60

gaacttctgg aagcaagatg caggacccca acgcagacac cgagtggaat gacatccttc      120

gtaaaaaggg catccttccc cctaaggaga gcctgaagga gctggaggag gaggaggagg      180

gaaaggagga gcagcgtctc cagcagtcag tggtgaagac atatgaagac atgaccctgg      240

aggagctgca ggagaacgaa gacgagttca gtgaggagga cgagcgagcc atcgagatgt      300

accggcagca aaggctggcc gagtggaagg cgactcagct gaggaacaag tttggagaag      360

ttttagagat ctcggggaag gattacgttc aagaagtcac caaggctggc gagggcttgt      420

gggtggtctt acacctgtac aaacaaggga ttcccctctg ttccttgata aaccatcact      480

tgagtgggct cgccaggaag tttcccgatg tgaaatttat caaagccatt tcaacgacct      540

gcatacccaa ttaccctgac aggaacctcc ccacagtgtt cgtctaccgg gagggggata      600

tcaaggcaca gttcatcggt cccctggtgt tcggtggcat gaacctgacc atagatgagt      660

tggagtggaa actatctgag tcaggagcaa tcaagacaga gctggaggag aaccccaaga      720

aagccatcaa agacgtgctg ctgtcctcag tgcgggaccc tgtccccatg aggagggaca      780

gtgattccga ggacgactaa gatagcagtg atgcagcctt tcgaactctc ttgataagac      840

gcattgtctg gagtttcaat aaggagggaa aagcaataat ttatcctttt gggttttaac      900

ctttttataa ttatttaaat tttatacatt tcagatataa tcattgctga aattttttaa      960

gaaatttgtt ggaactcttt ataatgtttc tttaagaatt taagctctta tgtcacatat     1020

ccatgttttc ctacatgtgt ttcagcaaac cctgtgactg tttagtatct tttgacatgc     1080

aactatagag aaaggaatgt ggagtttaaa aacacaatgc aaataaatta agttaaaaac     1140

taaaacataa cagtgcagaa aacaagaact cggctttata gttaagtcag actgtccatt     1200

ttcattttat aaagctagca aaagaaatat cagctgatag aaatggctga taattttgag     1260

acaaatactg tcttatcaaa ctagctgaca gatttcagct tacaccatgt ttgtattcag     1320

gtcagtcttc cagttaactc acgtgtgtct ctggctgtta agacaccagc tgttctttgt     1380

ggtggcacat gcttttaatc ccagcactgg gacacaggca ggcaggtcat gtgagttcaa     1440

ggctggtctg gcttgcaggg ccagggccac ctcaccaaga ccctgtcttg aagccaaaaa     1500

cagagctgtt cttggctcta aggtcctgtt aggttcggct tgggggactg aggtttaagc     1560

acacacacat gtaagctgtg tcccagctga tttataaaaa tgtttcggga tactctttga     1620

gtcagaatcc tataaattga tgatgaaagc tgaaaagtat caataatatt tttgttgaat     1680

gtggtaacat gtatagctga ttggaacctt agagataaga gtctaagaat acaggatttg     1740

ttcagaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1784


<210> 7
<211> 1356
<212> PRT
<213> Homo sapiens

<400> 7
Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210> 8
<211> 6055
<212> DNA
<213> Homo sapiens

<400> 8
actgagtccc gggaccccgg gagagcggtc aatgtgtggt cgctgcgttt cctctgcctg       60

cgccgggcat cacttgcgcg ccgcagaaag tccgtctggc agcctggata tcctctccta      120

ccggcacccg cagacgcccc tgcagccgcg gtcggcgccc gggctcccta gccctgtgcg      180

ctcaactgtc ctgcgctgcg gggtgccgcg agttccacct ccgcgcctcc ttctctagac      240

aggcgctggg agaaagaacc ggctcccgag ttctgggcat ttcgcccggc tcgaggtgca      300

ggatgcagag caaggtgctg ctggccgtcg ccctgtggct ctgcgtggag acccgggccg      360

cctctgtggg tttgcctagt gtttctcttg atctgcccag gctcagcata caaaaagaca      420

tacttacaat taaggctaat acaactcttc aaattacttg caggggacag agggacttgg      480

actggctttg gcccaataat cagagtggca gtgagcaaag ggtggaggtg actgagtgca      540

gcgatggcct cttctgtaag acactcacaa ttccaaaagt gatcggaaat gacactggag      600

cctacaagtg cttctaccgg gaaactgact tggcctcggt catttatgtc tatgttcaag      660

attacagatc tccatttatt gcttctgtta gtgaccaaca tggagtcgtg tacattactg      720

agaacaaaaa caaaactgtg gtgattccat gtctcgggtc catttcaaat ctcaacgtgt      780

cactttgtgc aagataccca gaaaagagat ttgttcctga tggtaacaga atttcctggg      840

acagcaagaa gggctttact attcccagct acatgatcag ctatgctggc atggtcttct      900

gtgaagcaaa aattaatgat gaaagttacc agtctattat gtacatagtt gtcgttgtag      960

ggtataggat ttatgatgtg gttctgagtc cgtctcatgg aattgaacta tctgttggag     1020

aaaagcttgt cttaaattgt acagcaagaa ctgaactaaa tgtggggatt gacttcaact     1080

gggaataccc ttcttcgaag catcagcata agaaacttgt aaaccgagac ctaaaaaccc     1140

agtctgggag tgagatgaag aaatttttga gcaccttaac tatagatggt gtaacccgga     1200

gtgaccaagg attgtacacc tgtgcagcat ccagtgggct gatgaccaag aagaacagca     1260

catttgtcag ggtccatgaa aaaccttttg ttgcttttgg aagtggcatg gaatctctgg     1320

tggaagccac ggtgggggag cgtgtcagaa tccctgcgaa gtaccttggt tacccacccc     1380

cagaaataaa atggtataaa aatggaatac cccttgagtc caatcacaca attaaagcgg     1440

ggcatgtact gacgattatg gaagtgagtg aaagagacac aggaaattac actgtcatcc     1500

ttaccaatcc catttcaaag gagaagcaga gccatgtggt ctctctggtt gtgtatgtcc     1560

caccccagat tggtgagaaa tctctaatct ctcctgtgga ttcctaccag tacggcacca     1620

ctcaaacgct gacatgtacg gtctatgcca ttcctccccc gcatcacatc cactggtatt     1680

ggcagttgga ggaagagtgc gccaacgagc ccagccaagc tgtctcagtg acaaacccat     1740

acccttgtga agaatggaga agtgtggagg acttccaggg aggaaataaa attgaagtta     1800

ataaaaatca atttgctcta attgaaggaa aaaacaaaac tgtaagtacc cttgttatcc     1860

aagcggcaaa tgtgtcagct ttgtacaaat gtgaagcggt caacaaagtc gggagaggag     1920

agagggtgat ctccttccac gtgaccaggg gtcctgaaat tactttgcaa cctgacatgc     1980

agcccactga gcaggagagc gtgtctttgt ggtgcactgc agacagatct acgtttgaga     2040

acctcacatg gtacaagctt ggcccacagc ctctgccaat ccatgtggga gagttgccca     2100

cacctgtttg caagaacttg gatactcttt ggaaattgaa tgccaccatg ttctctaata     2160

gcacaaatga cattttgatc atggagctta agaatgcatc cttgcaggac caaggagact     2220

atgtctgcct tgctcaagac aggaagacca agaaaagaca ttgcgtggtc aggcagctca     2280

cagtcctaga gcgtgtggca cccacgatca caggaaacct ggagaatcag acgacaagta     2340

ttggggaaag catcgaagtc tcatgcacgg catctgggaa tccccctcca cagatcatgt     2400

ggtttaaaga taatgagacc cttgtagaag actcaggcat tgtattgaag gatgggaacc     2460

ggaacctcac tatccgcaga gtgaggaagg aggacgaagg cctctacacc tgccaggcat     2520

gcagtgttct tggctgtgca aaagtggagg catttttcat aatagaaggt gcccaggaaa     2580

agacgaactt ggaaatcatt attctagtag gcacggcggt gattgccatg ttcttctggc     2640

tacttcttgt catcatccta cggaccgtta agcgggccaa tggaggggaa ctgaagacag     2700

gctacttgtc catcgtcatg gatccagatg aactcccatt ggatgaacat tgtgaacgac     2760

tgccttatga tgccagcaaa tgggaattcc ccagagaccg gctgaagcta ggtaagcctc     2820

ttggccgtgg tgcctttggc caagtgattg aagcagatgc ctttggaatt gacaagacag     2880

caacttgcag gacagtagca gtcaaaatgt tgaaagaagg agcaacacac agtgagcatc     2940

gagctctcat gtctgaactc aagatcctca ttcatattgg tcaccatctc aatgtggtca     3000

accttctagg tgcctgtacc aagccaggag ggccactcat ggtgattgtg gaattctgca     3060

aatttggaaa cctgtccact tacctgagga gcaagagaaa tgaatttgtc ccctacaaga     3120

ccaaaggggc acgattccgt caagggaaag actacgttgg agcaatccct gtggatctga     3180

aacggcgctt ggacagcatc accagtagcc agagctcagc cagctctgga tttgtggagg     3240

agaagtccct cagtgatgta gaagaagagg aagctcctga agatctgtat aaggacttcc     3300

tgaccttgga gcatctcatc tgttacagct tccaagtggc taagggcatg gagttcttgg     3360

catcgcgaaa gtgtatccac agggacctgg cggcacgaaa tatcctctta tcggagaaga     3420

acgtggttaa aatctgtgac tttggcttgg cccgggatat ttataaagat ccagattatg     3480

tcagaaaagg agatgctcgc ctccctttga aatggatggc cccagaaaca atttttgaca     3540

gagtgtacac aatccagagt gacgtctggt cttttggtgt tttgctgtgg gaaatatttt     3600

ccttaggtgc ttctccatat cctggggtaa agattgatga agaattttgt aggcgattga     3660

aagaaggaac tagaatgagg gcccctgatt atactacacc agaaatgtac cagaccatgc     3720

tggactgctg gcacggggag cccagtcaga gacccacgtt ttcagagttg gtggaacatt     3780

tgggaaatct cttgcaagct aatgctcagc aggatggcaa agactacatt gttcttccga     3840

tatcagagac tttgagcatg gaagaggatt ctggactctc tctgcctacc tcacctgttt     3900

cctgtatgga ggaggaggaa gtatgtgacc ccaaattcca ttatgacaac acagcaggaa     3960

tcagtcagta tctgcagaac agtaagcgaa agagccggcc tgtgagtgta aaaacatttg     4020

aagatatccc gttagaagaa ccagaagtaa aagtaatccc agatgacaac cagacggaca     4080

gtggtatggt tcttgcctca gaagagctga aaactttgga agacagaacc aaattatctc     4140

catcttttgg tggaatggtg cccagcaaaa gcagggagtc tgtggcatct gaaggctcaa     4200

accagacaag cggctaccag tccggatatc actccgatga cacagacacc accgtgtact     4260

ccagtgagga agcagaactt ttaaagctga tagagattgg agtgcaaacc ggtagcacag     4320

cccagattct ccagcctgac tcggggacca cactgagctc tcctcctgtt taaaaggaag     4380

catccacacc cccaactcct ggacatcaca tgagaggtgc tgctcagatt ttcaagtgtt     4440

gttctttcca ccagcaggaa gtagccgcat ttgattttca tttcgacaac agaaaaagga     4500

cctcggactg cagggagcca gtcttctagg catatcctgg aagaggcttg tgacccaaga     4560

atgtgtctgt gtcttctccc agtgttgacc tgatcctctt tttcattcat ttaaaaagca     4620

tttatcatgc cccctgctgc gggtctcacc atgggtttag aacaaagacg ttcaagaaat     4680

ggccccatcc tcaaagaagt agcagtacct ggggagctga cacttctgta aaactagaag     4740

ataaaccagg caatgtaagt gttcgaggtg ttgaagatgg gaaggatttg cagggctgag     4800

tctatccaag aggctttgtt taggacgtgg gtcccaagcc aagccttaag tgtggaattc     4860

ggattgatag aaaggaagac taacgttacc ttgctttgga gagtactgga gcctgcaaat     4920

gcattgtgtt tgctctggtg gaggtgggca tggggtctgt tctgaaatgt aaagggttca     4980

gacggggttt ctggttttag aaggttgcgt gttcttcgag ttgggctaaa gtagagttcg     5040

ttgtgctgtt tctgactcct aatgagagtt ccttccagac cgttacgtgt ctcctggcca     5100

agccccagga aggaaatgat gcagctctgg ctccttgtct cccaggctga tcctttattc     5160

agaataccac aaagaaagga cattcagctc aaggctccct gccgtgttga agagttctga     5220

ctgcacaaac cagcttctgg tttcttctgg aatgaatacc ctcatatctg tcctgatgtg     5280

atatgtctga gactgaatgc gggaggttca atgtgaagct gtgtgtggtg tcaaagtttc     5340

aggaaggatt ttaccctttt gttcttcccc ctgtccccaa cccactctca ccccgcaacc     5400

catcagtatt ttagttattt ggcctctact ccagtaaacc tgattgggtt tgttcactct     5460

ctgaatgatt attagccaga cttcaaaatt attttatagc ccaaattata acatctattg     5520

tattatttag acttttaaca tatagagcta tttctactga tttttgccct tgttctgtcc     5580

tttttttcaa aaaagaaaat gtgttttttg tttggtacca tagtgtgaaa tgctgggaac     5640

aatgactata agacatgcta tggcacatat atttatagtc tgtttatgta gaaacaaatg     5700

taatatatta aagccttata tataatgaac tttgtactat tcacattttg tatcagtatt     5760

atgtagcata acaaaggtca taatgctttc agcaattgat gtcattttat taaagaacat     5820

tgaaaaactt gaaggaatcc ctttgcaagg ttgcattact gtacccatca tttctaaaat     5880

ggaagagggg gtggctgggc acagtggccg acacctaaaa acccagcact ttggggggcc     5940

aaggtgggag gatcgcttga gcccaggagt tcaagaccag tctggccaac atggtcagat     6000

tccatctcaa agaaaaaagg taaaaataaa ataaaatgga gaagaaggaa tcaga          6055


<210> 9
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Gln Asp Pro Asn Ala Asp Thr Glu Trp Asn Asp Ile Leu Arg Lys 
1               5                   10                  15      


Lys Gly Ile Leu Pro Pro Lys Glu Ser Leu Lys Glu Leu Glu Glu Glu 
            20                  25                  30          


Ala Glu Glu Glu Gln Arg Ile Leu Gln Gln Ser Val Val Lys Thr Tyr 
        35                  40                  45              


Glu Asp 
    50  


<210> 10
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
cggtgtctgc gtttgggtcc tgcat                                             25


<210> 11
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(21)
<223> a, c, t, g, unknown or other

<400> 11
aannnnnnnn nnnnnnnnnn ntt                                               23


<210> 12
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      'KDEL' family peptide motif sequence

<400> 12
Lys Asp Glu Leu 
1               


<210> 13
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 13
His His His His His His 
1               5       


<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Met Gln Asp Pro Asn Ala Asp Thr Glu Trp Asn Asp Ile Leu Arg 
1               5                   10                  15  


