                         SEQUENCE LISTING

<110>  MOLMED SpA
 
<120>  Chimeric Antigen Receptors

<130>  P105739PCT

<150>  EP 14184838.2
<151>  2014-09-15

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer LNGFR wild-type long (NWL)

<400>  1

Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
1               5                   10                  15      


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
            20                  25                  30          


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
        35                  40                  45              


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
    50                  55                  60                  


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
65                  70                  75                  80  


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
                85                  90                  95      


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
            100                 105                 110         


Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
        115                 120                 125             


Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp 
    130                 135                 140                 


Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys 
145                 150                 155                 160 


Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly 
                165                 170                 175     


Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu 
            180                 185                 190         


Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met 
        195                 200                 205             


Gly Ser Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn 
    210                 215                 220         


<210>  2
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer LNGFR wild-type long (NWL)

<400>  2
aaagaggcct gccccaccgg cctgtacacc cacagcggag agtgctgcaa ggcctgcaac       60

ctgggagagg gcgtggccca gccttgcggc gccaatcaga ccgtgtgcga gccctgcctg      120

gacagcgtga ccttcagcga cgtggtgtcc gccaccgagc cctgcaagcc ttgcaccgag      180

tgtgtgggcc tgcagagcat gagcgccccc tgcgtggaag ccgacgacgc cgtgtgtaga      240

tgcgcctacg gctactacca ggacgagaca accggcagat gcgaggcctg tagagtgtgc      300

gaggccggca gcggcctggt gttcagttgt caagacaagc agaataccgt gtgtgaagag      360

tgccccgacg gcacctacag cgacgaggcc aaccacgtgg acccctgcct gccctgcact      420

gtgtgcgagg acaccgagcg gcagctgcgc gagtgcacaa gatgggccga cgccgagtgc      480

gaagagatcc ccggcagatg gatcaccaga agcacccccc ctgagggcag cgacagcacc      540

gcccctagca cccaggaacc tgaggcccct cccgagcagg acctgatcgc ctctacagtg      600

gccggcgtgg tgacaaccgt gatgggcagc tctcagcccg tggtgacacg gggcaccacc      660

gacaat                                                                 666


<210>  3
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer LNGFR wild-type short (NWS)

<400>  3

Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
1               5                   10                  15      


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
            20                  25                  30          


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
        35                  40                  45              


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
    50                  55                  60                  


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
65                  70                  75                  80  


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
                85                  90                  95      


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
            100                 105                 110         


Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
        115                 120                 125             


Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp 
    130                 135                 140                 


Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys 
145                 150                 155                 160 


Glu Glu 
        


<210>  4
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer LNGFR wild-type short (NWS)

<400>  4
aaagaggcct gccccaccgg cctgtacacc cacagcggag agtgctgcaa ggcctgcaac       60

ctgggagagg gcgtggccca gccttgcggc gccaatcaga ccgtgtgcga gccctgcctg      120

gacagcgtga ccttcagcga cgtggtgtcc gccaccgagc cctgcaagcc ttgcaccgag      180

tgtgtgggcc tgcagagcat gagcgccccc tgcgtggaag ccgacgacgc cgtgtgtaga      240

tgcgcctacg gctactacca ggacgagaca accggcagat gcgaggcctg tagagtgtgc      300

gaggccggca gcggcctggt gttcagttgt caggacaagc agaacaccgt gtgtgaagag      360

tgccccgacg gcacctacag cgacgaggcc aaccacgtgg acccctgcct gccctgcact      420

gtgtgcgagg acaccgagcg gcagctgcgc gagtgcacaa gatgggccga cgccgagtgc      480

gaggaa                                                                 486


<210>  5
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer LNGFR mutated long (NML)

<400>  5

Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
1               5                   10                  15      


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
            20                  25                  30          


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
        35                  40                  45              


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
    50                  55                  60                  


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
65                  70                  75                  80  


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
                85                  90                  95      


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
            100                 105                 110         


Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
        115                 120                 125             


Glu Ala Ala Arg Ala Ala Asp Ala Glu Cys Glu Glu Ile Pro Gly Arg 
    130                 135                 140                 


Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr Ala Pro 
145                 150                 155                 160 


Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile Ala Ser 
                165                 170                 175     


Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln Pro Val 
            180                 185                 190         


Val Thr Arg Gly Thr Thr Asp Asn 
        195                 200 


<210>  6
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer LNGFR mutated long (NML)

<400>  6
aaagaggcct gccccaccgg cctgtacacc cacagcggag agtgctgcaa ggcctgcaac       60

ctgggagagg gcgtggccca gccttgcggc gccaatcaga ccgtgtgcga gccctgcctg      120

gacagcgtga ccttcagcga cgtggtgtcc gccaccgagc cctgcaagcc ttgcaccgag      180

tgtgtgggcc tgcagagcat gagcgccccc tgcgtggaag ccgacgacgc cgtgtgtaga      240

tgcgcctacg gctactacca ggacgagaca accggcagat gcgaggcctg tagagtgtgc      300

gaggccggca gcggcctggt gttcagttgt caagacaagc agaataccgt gtgtgaagag      360

tgccccgacg gcacctacag cgacgaagcc gccagagccg ccgacgccga gtgcgaagag      420

atccccggca gatggatcac cagaagcacc ccccctgagg gcagcgacag caccgcccct      480

agcacccagg aacctgaggc ccctcccgag caggacctga tcgcctctac agtggccggc      540

gtggtgacaa ccgtgatggg cagctctcag cccgtggtga cacggggcac caccgacaat      600


<210>  7
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer LNGFR mutated short (NMS)

<400>  7

Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
1               5                   10                  15      


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
            20                  25                  30          


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
        35                  40                  45              


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
    50                  55                  60                  


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
65                  70                  75                  80  


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
                85                  90                  95      


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
            100                 105                 110         


Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
        115                 120                 125             


Glu Ala Ala Arg Ala Ala Asp Ala Glu Cys Glu Glu 
    130                 135                 140 


<210>  8
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer LNGFR mutated short (NMS)

<400>  8
aaagaggcct gccccaccgg cctgtacacc cacagcggag agtgctgcaa ggcctgcaac       60

ctgggagagg gcgtggccca gccttgcggc gccaatcaga ccgtgtgcga gccctgcctg      120

gacagcgtga ccttcagcga cgtggtgtcc gccaccgagc cctgcaagcc ttgcaccgag      180

tgtgtgggcc tgcagagcat gagcgccccc tgcgtggaag ccgacgacgc cgtgtgtaga      240

tgcgcctacg gctactacca ggacgagaca accggcagat gcgaggcctg tagagtgtgc      300

gaggccggca gcggcctggt gttcagttgt caggacaagc agaacaccgt gtgtgaagag      360

tgccccgacg gcacctacag cgacgaggcc gcccgggccg ccgacgccga gtgcgaggaa      420


<210>  9
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala 
1               5                   10                  15      


Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr 
            20                  25                  30          


Val Cys 
        


<210>  10
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  10

Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu 
1               5                   10                  15      


Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala 
            20                  25                  30          


Pro Cys Val Glu Ala Asp Asp Ala Val Cys 
        35                  40          


<210>  11
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu 
1               5                   10                  15      


Ala Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln 
            20                  25                  30          


Asp Lys Gln Asn Thr Val Cys 
        35                  


<210>  12
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp Pro 
1               5                   10                  15      


Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu 
            20                  25                  30          


Cys Thr Arg Trp Ala Asp Ala Glu Cys 
        35                  40      


<210>  13
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  13

Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu 
1               5                   10                  15      


Arg Gln Leu Arg Glu Cys Thr Arg Trp 
            20                  25  


<210>  14
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 
            20                  25                  30          


Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn 
        35                  40                  45              


Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 
    50                  55                  60                  


Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 
65                  70                  75                  80  


Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 
                85                  90                  95      


Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 
            100                 105                 110         


Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 
        115                 120                 125             


Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 
    130                 135                 140                 


Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 
145                 150                 155                 160 


Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 
                165                 170                 175     


Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 
            180                 185                 190         


Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 
        195                 200                 205             


Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 
    210                 215                 220                 


Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln 
225                 230                 235                 240 


Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 
                245                 250                 255     


Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 
            260                 265                 270         


Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg 
        275                 280                 285             


Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp 
    290                 295                 300                 


Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Pro His 
305                 310                 315                 320 


Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Gly Leu Tyr 
                325                 330                 335     


Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu Leu Asn 
            340                 345                 350         


Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr 
        355                 360                 365             


Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg 
    370                 375                 380                 


Ala Leu Leu Ala Ser Trp Ala Thr Gln Asp Ser Ala Thr Leu Asp Ala 
385                 390                 395                 400 


Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Leu Val Glu Ser 
                405                 410                 415     


Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 
            420                 425         


<210>  15
<211>  2046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD44v6-specific second-generation CAR construct sequence, 
       CD44v6-CAR.28z

<400>  15
atggaagccc ctgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggc       60

gagatcgtgc tgacacagag ccccgccacc ctgtctctga gccctggcga gagagccacc      120

ctgagctgta gcgccagcag cagcatcaac tacatctact ggctgcagca gaagcccggc      180

caggccccca gaatcctgat ctacctgacc agcaacctgg ccagcggcgt gcccgccaga      240

ttttctggca gcggcagcgg caccgacttc accctgacca tcagcagcct ggaacccgag      300

gacttcgccg tgtactactg cctgcagtgg tccagcaacc ccctgacctt cggcggaggc      360

accaaggtgg aaatcaagcg gggtggtggt ggttctggtg gtggtggttc tggcggcggc      420

ggctccggtg gtggtggatc tgaggtgcag ctggtggaaa gcggcggagg cctggtcaag      480

cctggcggca gcctgagact gagctgtgcc gccagcggct tcaccttcag cagctacgac      540

atgagctggg tccgacaggc tccaggcaag ggactggaat gggtgtccac catcagcagc      600

ggcggcagct acacctacta cctggacagc atcaagggcc ggttcaccat cagccgggac      660

aacgccaaga acagcctgta cctgcagatg aacagcctgc gggccgagga caccgccgtc      720

tactactgtg cccggcaggg cctcgactac tggggcagag gcaccctggt caccgtgtcc      780

agcggggatc ccgccgagcc caaatctcct gacaaaactc acacatgccc accgtgccca      840

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      900

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      960

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1020

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1080

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1140

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1200

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1260

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcaacc ggagaacaac     1320

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1380

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1440

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa aaaagatccc     1500

aaattttggg tgctggtggt ggttggtgga gtcctggctt gctatagctt gctagtaaca     1560

gtggccttta ttattttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac     1620

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca     1680

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc     1740

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1800

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1860

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1920

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1980

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     2040

cgctaa                                                                2046


<210>  16
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-CAR.28z protein

<400>  16

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
305                 310                 315                 320 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495     


Lys Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
            500                 505                 510         


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
        515                 520                 525             


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    530                 535                 540                 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
545                 550                 555                 560 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
                565                 570                 575     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            580                 585                 590         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        595                 600                 605             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    610                 615                 620                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
625                 630                 635                 640 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                645                 650                 655     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            660                 665                 670         


Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680     


<210>  17
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-specific single-chain fragment

<400>  17

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  18
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  19
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  19

Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
1               5                   10                  15      


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
            20                  25                  30          


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
        35                  40                  45              


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
    50                  55                  60                  


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
65                  70                  75                  80  


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
                85                  90                  95      


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
            100                 105                 110         


Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
        115                 120                 125             


Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp 
    130                 135                 140                 


Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys 
145                 150                 155                 160 


Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly 
                165                 170                 175     


Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu 
            180                 185                 190         


Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met 
        195                 200                 205             


Gly Ser Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn 
    210                 215                 220         


<210>  20
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  21
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-CAR28z with spacer LNGFR wild-type long (NWL)

<400>  21

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Asp Pro Lys Glu Ala Cys Pro Thr Gly Leu 
            260                 265                 270         


Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly 
        275                 280                 285             


Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu 
    290                 295                 300                 


Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys 
305                 310                 315                 320 


Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val 
                325                 330                 335     


Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp 
            340                 345                 350         


Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser 
        355                 360                 365             


Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu 
    370                 375                 380                 


Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys 
385                 390                 395                 400 


Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys 
                405                 410                 415     


Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro Gly Arg Trp Ile 
            420                 425                 430         


Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr Ala Pro Ser Thr 
        435                 440                 445             


Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile Ala Ser Thr Val 
    450                 455                 460                 


Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln Pro Val Val Thr 
465                 470                 475                 480 


Arg Gly Thr Thr Asp Asn Pro Lys Phe Trp Val Leu Val Val Val Gly 
                485                 490                 495     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            500                 505                 510         


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        515                 520                 525             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    530                 535                 540                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
545                 550                 555                 560 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                565                 570                 575     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            580                 585                 590         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
        595                 600                 605             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    610                 615                 620                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
625                 630                 635                 640 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                645                 650                 655     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 


<210>  22
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-CAR28z with spacer LNGFR wild-type short (NWS)

<400>  22

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Asp Pro Lys Glu Ala Cys Pro Thr Gly Leu 
            260                 265                 270         


Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly 
        275                 280                 285             


Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu 
    290                 295                 300                 


Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys 
305                 310                 315                 320 


Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val 
                325                 330                 335     


Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp 
            340                 345                 350         


Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser 
        355                 360                 365             


Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu 
    370                 375                 380                 


Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys 
385                 390                 395                 400 


Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys 
                405                 410                 415     


Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Pro Lys Phe Trp Val Leu 
            420                 425                 430         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        435                 440                 445             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    450                 455                 460                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
465                 470                 475                 480 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                485                 490                 495     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            500                 505                 510         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        515                 520                 525             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    530                 535                 540                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
545                 550                 555                 560 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                565                 570                 575     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            580                 585                 590         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        595                 600                 605             


Arg 
    


<210>  23
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-CAR28z with spacer LNGFR mutated long (NML)

<400>  23

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Asp Pro Lys Glu Ala Cys Pro Thr Gly Leu 
            260                 265                 270         


Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly 
        275                 280                 285             


Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu 
    290                 295                 300                 


Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys 
305                 310                 315                 320 


Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val 
                325                 330                 335     


Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp 
            340                 345                 350         


Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser 
        355                 360                 365             


Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu 
    370                 375                 380                 


Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Ala Arg Ala Ala Asp Ala 
385                 390                 395                 400 


Glu Cys Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro 
                405                 410                 415     


Glu Gly Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro 
            420                 425                 430         


Pro Glu Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr 
        435                 440                 445             


Val Met Gly Ser Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn 
    450                 455                 460                 


Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
465                 470                 475                 480 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
                485                 490                 495     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            500                 505                 510         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        515                 520                 525             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    530                 535                 540                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
545                 550                 555                 560 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                565                 570                 575     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            580                 585                 590         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        595                 600                 605             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    610                 615                 620                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
625                 630                 635                 640 


Met Gln Ala Leu Pro Pro Arg 
                645         


<210>  24
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-CAR28z with spacer LNGFR mutated short (NMS)

<400>  24

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Asp Pro Lys Glu Ala Cys Pro Thr Gly Leu 
            260                 265                 270         


Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly 
        275                 280                 285             


Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu 
    290                 295                 300                 


Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys 
305                 310                 315                 320 


Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val 
                325                 330                 335     


Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp 
            340                 345                 350         


Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser 
        355                 360                 365             


Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu 
    370                 375                 380                 


Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Ala Arg Ala Ala Asp Ala 
385                 390                 395                 400 


Glu Cys Glu Glu Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val 
                405                 410                 415     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            420                 425                 430         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        435                 440                 445             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    450                 455                 460                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
465                 470                 475                 480 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                485                 490                 495     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            500                 505                 510         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585         


<210>  25
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-CAR28z with spacer LNGFR wild-type long (NWL)

<400>  25

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Asp Pro Lys Glu Ala Cys Pro Thr Gly Leu 
            260                 265                 270         


Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly 
        275                 280                 285             


Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu 
    290                 295                 300                 


Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys 
305                 310                 315                 320 


Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val 
                325                 330                 335     


Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp 
            340                 345                 350         


Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser 
        355                 360                 365             


Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu 
    370                 375                 380                 


Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys 
385                 390                 395                 400 


Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys 
                405                 410                 415     


Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro Gly Arg Trp Ile 
            420                 425                 430         


Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr Ala Pro Ser Thr 
        435                 440                 445             


Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile Ala Ser Thr Val 
    450                 455                 460                 


Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln Pro Val Val Thr 
465                 470                 475                 480 


Arg Gly Thr Thr Asp Asn Pro Lys Phe Trp Val Leu Val Val Val Gly 
                485                 490                 495     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            500                 505                 510         


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        515                 520                 525             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    530                 535                 540                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
545                 550                 555                 560 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                565                 570                 575     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            580                 585                 590         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        595                 600                 605             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    610                 615                 620                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
625                 630                 635                 640 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                645                 650                 655     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665             


<210>  26
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-CAR28z with spacer LNGFR wild-type short (NWS)

<400>  26

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Asp Pro Lys Glu Ala Cys Pro Thr Gly Leu 
            260                 265                 270         


Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly 
        275                 280                 285             


Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu 
    290                 295                 300                 


Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys 
305                 310                 315                 320 


Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val 
                325                 330                 335     


Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp 
            340                 345                 350         


Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser 
        355                 360                 365             


Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu 
    370                 375                 380                 


Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys 
385                 390                 395                 400 


Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys 
                405                 410                 415     


Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Pro Lys Phe Trp Val Leu 
            420                 425                 430         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        435                 440                 445             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    450                 455                 460                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
465                 470                 475                 480 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                485                 490                 495     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            500                 505                 510         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        515                 520                 525             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    530                 535                 540                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
545                 550                 555                 560 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                565                 570                 575     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            580                 585                 590         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600                 605             


<210>  27
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-CAR28z with spacer LNGFR mutated long (NWL)

<400>  27

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Asp Pro Lys Glu Ala Cys Pro Thr Gly Leu 
            260                 265                 270         


Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly 
        275                 280                 285             


Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu 
    290                 295                 300                 


Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys 
305                 310                 315                 320 


Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val 
                325                 330                 335     


Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp 
            340                 345                 350         


Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser 
        355                 360                 365             


Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu 
    370                 375                 380                 


Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Ala Arg Ala Ala Asp Ala 
385                 390                 395                 400 


Glu Cys Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro 
                405                 410                 415     


Glu Gly Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro 
            420                 425                 430         


Pro Glu Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr 
        435                 440                 445             


Val Met Gly Ser Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn 
    450                 455                 460                 


Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
465                 470                 475                 480 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
                485                 490                 495     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            500                 505                 510         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        515                 520                 525             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    530                 535                 540                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
545                 550                 555                 560 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                565                 570                 575     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            580                 585                 590         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        595                 600                 605             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    610                 615                 620                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
625                 630                 635                 640 


Gln Ala Leu Pro Pro Arg 
                645     


<210>  28
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-CAR28z with spacer LNGFR mutated short (NWL)

<400>  28

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu 
        195                 200                 205             


Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr Trp Gly Arg Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Asp Pro Lys Glu Ala Cys Pro Thr Gly Leu 
            260                 265                 270         


Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly 
        275                 280                 285             


Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu 
    290                 295                 300                 


Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys 
305                 310                 315                 320 


Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val 
                325                 330                 335     


Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp 
            340                 345                 350         


Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser 
        355                 360                 365             


Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu 
    370                 375                 380                 


Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Ala Arg Ala Ala Asp Ala 
385                 390                 395                 400 


Glu Cys Glu Glu Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val 
                405                 410                 415     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            420                 425                 430         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        435                 440                 445             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    450                 455                 460                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
465                 470                 475                 480 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                485                 490                 495     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            500                 505                 510         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        515                 520                 525             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    530                 535                 540                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
545                 550                 555                 560 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                565                 570                 575     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585     


<210>  29
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  29

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  30
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  31
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-4GS2, CD44v6-specific single chain fragment

<400>  31

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met Ser Trp Val Arg Gln 
                165                 170                 175     


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Ser Tyr Thr Tyr Tyr Leu Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr 
225                 230                 235                 240 


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  32
<211>  658
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-4GS2-CAR28z with spacer LNGFR wild-type long (NWL)

<400>  32

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met Ser Trp Val Arg Gln 
                165                 170                 175     


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Ser Tyr Thr Tyr Tyr Leu Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr 
225                 230                 235                 240 


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Asp Pro Lys Glu 
                245                 250                 255     


Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala 
            260                 265                 270         


Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr 
        275                 280                 285             


Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser 
    290                 295                 300                 


Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser 
305                 310                 315                 320 


Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala 
                325                 330                 335     


Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg 
            340                 345                 350         


Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln 
        355                 360                 365             


Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala 
    370                 375                 380                 


Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu 
385                 390                 395                 400 


Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu 
                405                 410                 415     


Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp 
            420                 425                 430         


Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp 
        435                 440                 445             


Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser 
    450                 455                 460                 


Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn Pro Lys Phe Trp 
465                 470                 475                 480 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                485                 490                 495     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            500                 505                 510         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        515                 520                 525             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    530                 535                 540                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
545                 550                 555                 560 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                565                 570                 575     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            580                 585                 590         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        595                 600                 605             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    610                 615                 620                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
625                 630                 635                 640 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                645                 650                 655     


Pro Arg 
        


<210>  33
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-4GS2-CAR28z with spacer LNGFR wild-type short (NWS)

<400>  33

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met Ser Trp Val Arg Gln 
                165                 170                 175     


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Ser Tyr Thr Tyr Tyr Leu Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr 
225                 230                 235                 240 


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Asp Pro Lys Glu 
                245                 250                 255     


Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala 
            260                 265                 270         


Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr 
        275                 280                 285             


Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser 
    290                 295                 300                 


Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser 
305                 310                 315                 320 


Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala 
                325                 330                 335     


Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg 
            340                 345                 350         


Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln 
        355                 360                 365             


Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala 
    370                 375                 380                 


Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu 
385                 390                 395                 400 


Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu 
                405                 410                 415     


Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
            420                 425                 430         


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
        435                 440                 445             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    450                 455                 460                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
465                 470                 475                 480 


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                485                 490                 495     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            500                 505                 510         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        515                 520                 525             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    530                 535                 540                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
545                 550                 555                 560 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                565                 570                 575     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            580                 585                 590         


Gln Ala Leu Pro Pro Arg 
        595             


<210>  34
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-4GS2-CAR28z with spacer LNGFR mutated long (NML)

<400>  34

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met Ser Trp Val Arg Gln 
                165                 170                 175     


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Ser Tyr Thr Tyr Tyr Leu Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr 
225                 230                 235                 240 


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Asp Pro Lys Glu 
                245                 250                 255     


Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala 
            260                 265                 270         


Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr 
        275                 280                 285             


Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser 
    290                 295                 300                 


Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser 
305                 310                 315                 320 


Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala 
                325                 330                 335     


Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg 
            340                 345                 350         


Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln 
        355                 360                 365             


Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala 
    370                 375                 380                 


Ala Arg Ala Ala Asp Ala Glu Cys Glu Glu Ile Pro Gly Arg Trp Ile 
385                 390                 395                 400 


Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr Ala Pro Ser Thr 
                405                 410                 415     


Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile Ala Ser Thr Val 
            420                 425                 430         


Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln Pro Val Val Thr 
        435                 440                 445             


Arg Gly Thr Thr Asp Asn Pro Lys Phe Trp Val Leu Val Val Val Gly 
    450                 455                 460                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
465                 470                 475                 480 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                485                 490                 495     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            500                 505                 510         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
        515                 520                 525             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    530                 535                 540                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
545                 550                 555                 560 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                565                 570                 575     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            580                 585                 590         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        595                 600                 605             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    610                 615                 620                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635     


<210>  35
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44v6-4GS2-CAR28z with spacer LNGFR mutated short (NMS)

<400>  35

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Asn Tyr Ile Tyr Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Ile Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met Ser Trp Val Arg Gln 
                165                 170                 175     


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Ser Tyr Thr Tyr Tyr Leu Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr 
225                 230                 235                 240 


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Asp Pro Lys Glu 
                245                 250                 255     


Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala 
            260                 265                 270         


Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr 
        275                 280                 285             


Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser 
    290                 295                 300                 


Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser 
305                 310                 315                 320 


Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala 
                325                 330                 335     


Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg 
            340                 345                 350         


Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln 
        355                 360                 365             


Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala 
    370                 375                 380                 


Ala Arg Ala Ala Asp Ala Glu Cys Glu Glu Pro Lys Phe Trp Val Leu 
385                 390                 395                 400 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                405                 410                 415     


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            420                 425                 430         


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
        435                 440                 445             


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    450                 455                 460                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
465                 470                 475                 480 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                485                 490                 495     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            500                 505                 510         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        515                 520                 525             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    530                 535                 540                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
545                 550                 555                 560 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                565                 570                 575     


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  36

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  37
<211>  8331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD44v6-4GS2-CAR.28Z NGFR WILD TYPE LONG (V6 NWL)

<400>  37
aagctttgct cttaggagtt tcctaataca tcccaaactc aaatatataa agcatttgac       60

ttgttctatg ccctaggggg cggggggaag ctaagccagc tttttttaac atttaaaatg      120

ttaattccat tttaaatgca cagatgtttt tatttcataa gggtttcaat gtgcatgaat      180

gctgcaatat tcctgttacc aaagctagta taaataaaaa tagataaacg tggaaattac      240

ttagagtttc tgtcattaac gtttccttcc tcagttgaca acataaatgc gctgctgagc      300

aagccagttt gcatctgtca ggatcaattt cccattatgc cagtcatatt aattactagt      360

caattagttg atttttattt ttgacatata catgtgaatg aaagacccca cctgtaggtt      420

tggcaagcta gcttaagtaa cgccattttg caaggcatgg aaaaatacat aactgagaat      480

agaaaagttc agatcaaggt caggaacaga tggaacagct gaatatgggc caaacaggat      540

atctgtggta agcagttcct gccccggctc agggccaaga acagatggaa cagctgaata      600

tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacaga      660

tggtccccag atgcggtcca gccctcagca gtttctagag aaccatcaga tgtttccagg      720

gtgccccaag gacctgaaat gaccctgtgc cttatttgaa ctaaccaatc agttcgcttc      780

tcgcttctgt tcgcgcgctt atgctccccg agctcaataa aagagcccac aacccctcac      840

tcggggcgcc agtcctccga ttgactgagt cgcccgggta cccgtgtatc caataaaccc      900

tcttgcagtt gcatccgact tgtggtctcg ctgttccttg ggagggtctc ctctgagtga      960

ttgactaccc gtcagcgggg gtctttcatt tgggggctcg tccgggatcg ggagacccct     1020

gcccagggac caccgaccca ccaccgggag gtaagctggc cagcaactta tctgtgtctg     1080

tccgattgtc tagtgtctat gactgatttt atgcgcctgc gtcggtacta gttagctaac     1140

tagctctgta tctggcggac ccgtggtgga actgacgagt tcggaacacc cggccgcaac     1200

cctgggagac gtcccaggga cttcgggggc cgtttttgtg gcccgacctg agtcctaaaa     1260

tcccgatcgt ttaggactct ttggtgcacc ccccttagag gagggatatg tggttctggt     1320

aggagacgag aacctaaaac agttcccgcc tccgtctgaa tttttgcttt cggtttggga     1380

ccgaagccgc gccgcgcgtc ttgtctgctg cagcatcgtt ctgtgttgtc tctgtctgac     1440

tgtgtttctg tatttgtctg aaaatatggg cccgggctag cctgttacca ctcccttaag     1500

tttgacctta ggtcactgga aagatgtcga gcggatcgct cacaaccagt cggtagatgt     1560

caagaagaga cgttgggtta ccttctgctc tgcagaatgg ccaaccttta acgtcggatg     1620

gccgcgagac ggcaccttta accgagacct catcacccag gttaagatca aggtcttttc     1680

acctggcccg catggacacc cagaccaggt ggggtacatc gtgacctggg aagccttggc     1740

ttttgacccc cctccctggg tcaagccctt tgtacaccct aagcctccgc ctcctcttcc     1800

tccatccgcc ccgtctctcc cccttgaacc tcctcgttcg accccgcctc gatcctccct     1860

ttatccagcc ctcactcctt ctctaggcgc ccccatatgg ccatatgaga tcttatatgg     1920

ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta ctaacagccc     1980

ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct ggagacctct     2040

ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt accgagtcgg     2100

cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct ggaaaggacc     2160

ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg cagcttggat     2220

acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta gactgccatg     2280

gaagcccctg cccagctgct gttcctgctg ctgctgtggc tgcccgacac caccggcgag     2340

atcgtgctga cacagagccc cgccaccctg tctctgagcc ctggcgagag agccaccctg     2400

agctgtagcg ccagcagcag catcaactac atctactggc tgcagcagaa gcccggccag     2460

gcccccagaa tcctgatcta cctgaccagc aacctggcca gcggcgtgcc cgccagattt     2520

tctggcagcg gcagcggcac cgacttcacc ctgaccatca gcagcctgga acccgaggac     2580

ttcgccgtgt actactgcct gcagtggtcc agcaaccccc tgaccttcgg cggaggcacc     2640

aaggtggaaa tcaagcgggg tggtggtggt tctggtggtg gtggttctga ggtgcagctg     2700

gtggaaagcg gcggaggcct ggtcaagcct ggcggcagcc tgagactgag ctgtgccgcc     2760

agcggcttca ccttcagcag ctacgacatg agctgggtcc gacaggctcc aggcaaggga     2820

ctggaatggg tgtccaccat cagcagcggc ggcagctaca cctactacct ggacagcatc     2880

aagggccggt tcaccatcag ccgggacaac gccaagaaca gcctgtacct gcagatgaac     2940

agcctgcggg ccgaggacac cgccgtctac tactgtgccc ggcagggcct cgactactgg     3000

ggcagaggca ccctggtcac cgtgtccagc ggggatccca aagaggcctg ccccaccggc     3060

ctgtacaccc acagcggaga gtgctgcaag gcctgcaacc tgggagaggg cgtggcccag     3120

ccttgcggcg ccaatcagac cgtgtgcgag ccctgcctgg acagcgtgac cttcagcgac     3180

gtggtgtccg ccaccgagcc ctgcaagcct tgcaccgagt gtgtgggcct gcagagcatg     3240

agcgccccct gcgtggaagc cgacgacgcc gtgtgtagat gcgcctacgg ctactaccag     3300

gacgagacaa ccggcagatg cgaggcctgt agagtgtgcg aggccggcag cggcctggtg     3360

ttcagttgtc aagacaagca gaataccgtg tgtgaagagt gccccgacgg cacctacagc     3420

gacgaggcca accacgtgga cccctgcctg ccctgcactg tgtgcgagga caccgagcgg     3480

cagctgcgcg agtgcacaag atgggccgac gccgagtgcg aagagatccc cggcagatgg     3540

atcaccagaa gcaccccccc tgagggcagc gacagcaccg cccctagcac ccaggaacct     3600

gaggcccctc ccgagcagga cctgatcgcc tctacagtgg ccggcgtggt gacaaccgtg     3660

atgggcagct ctcagcccgt ggtgacacgg ggcaccaccg acaatcccaa attttgggtg     3720

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt     3780

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact     3840

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc     3900

gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     3960

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     4020

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     4080

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     4140

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     4200

gccaccaagg acacctacga cgcccttcac atgcaggccc tgcctcctcg ctaagcatgc     4260

aacctcgatc cggattagtc caatttgtta aagacaggat atcagtggtc caggctctag     4320

ttttgactca acaatatcac cagctgaagc ctatagagta cgagccatag ataaaataaa     4380

agattttatt tagtctccag aaaaaggggg gaatgaaaga ccccacctgt aggtttggca     4440

agctagctta agtaacgcca ttttgcaagg catggaaaaa tacataactg agaatagaga     4500

agttcagatc aaggtcagga acagatggaa cagctgaata tgggccaaac aggatatctg     4560

tggtaagcag ttcctgcccc ggctcagggc caagaacaga tggaacagct gaatatgggc     4620

caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc     4680

cccagatgcg gtccagccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc     4740

ccaaggacct gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct     4800

tctgttcgcg cgcttctgct ccccgagctc aataaaagag cccacaaccc ctcactcggg     4860

gcgccagtcc tccgattgac tgagtcgccc gggtacccgt gtatccaata aaccctcttg     4920

cagttgcatc cgacttgtgg tctcgctgtt ccttgggagg gtctcctctg agtgattgac     4980

tacccgtcag cgggggtctt tcacacatgc agcatgtatc aaaattaatt tggttttttt     5040

tcttaagtat ttacattaaa tggccatagt acttaaagtt acattggctt ccttgaaata     5100

aacatggagt attcagaatg tgtcataaat atttctaatt ttaagatagt atctccattg     5160

gctttctact ttttctttta tttttttttg tcctctgtct tccatttgtt gttgttgttg     5220

tttgtttgtt tgtttgttgg ttggttggtt aatttttttt taaagatcct acactatagt     5280

tcaagctaga ctattagcta ctctgtaacc cagggtgacc ttgaagtcat gggtagcctg     5340

ctgttttagc cttcccacat ctaagattac aggtatgagc tatcattttt ggtatattga     5400

ttgattgatt gattgatgtg tgtgtgtgtg attgtgtttg tgtgtgtgac tgtgaaaatg     5460

tgtgtatggg tgtgtgtgaa tgtgtgtatg tatgtgtgtg tgtgagtgtg tgtgtgtgtg     5520

tgtgcatgtg tgtgtgtgtg actgtgtcta tgtgtatgac tgtgtgtgtg tgtgtgtgtg     5580

tgtgtgtgtg tgtgtgtgtg tgtgtgttgt gaaaaaatat tctatggtag tgagagccaa     5640

cgctccggct caggtgtcag gttggttttt gagacagagt ctttcactta gcttggaatt     5700

cactggccgt cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc caacttaatc     5760

gccttgcagc acatccccct ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc     5820

gcccttccca acagttgcgc agcctgaatg gcgaatggcg cctgatgcgg tattttctcc     5880

ttacgcatct gtgcggtatt tcacaccgca tatggtgcac tctcagtaca atctgctctg     5940

atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     6000

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     6060

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgatgac gaaagggcct cgtgatacgc     6120

ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt     6180

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat     6240

ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg     6300

agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt     6360

tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga     6420

gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa     6480

gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt     6540

attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt     6600

gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc     6660

agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga     6720

ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat     6780

cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct     6840

gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc     6900

cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg     6960

gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc     7020

ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg     7080

acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca     7140

ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta     7200

aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc     7260

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     7320

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     7380

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     7440

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     7500

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     7560

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     7620

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     7680

cgaacgacct acaccgaact gagataccta cagcgtgagc attgagaaag cgccacgctt     7740

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     7800

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     7860

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     7920

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc     7980

tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat     8040

accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag     8100

cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg cagctggcac     8160

gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt gagttagctc     8220

actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt     8280

gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc c              8331


<210>  38
<211>  8151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD44V6-4GS2-CAR.28Z NGFR WILD TYPE SHORT (V6 NWS)

<400>  38
aagctttgct cttaggagtt tcctaataca tcccaaactc aaatatataa agcatttgac       60

ttgttctatg ccctaggggg cggggggaag ctaagccagc tttttttaac atttaaaatg      120

ttaattccat tttaaatgca cagatgtttt tatttcataa gggtttcaat gtgcatgaat      180

gctgcaatat tcctgttacc aaagctagta taaataaaaa tagataaacg tggaaattac      240

ttagagtttc tgtcattaac gtttccttcc tcagttgaca acataaatgc gctgctgagc      300

aagccagttt gcatctgtca ggatcaattt cccattatgc cagtcatatt aattactagt      360

caattagttg atttttattt ttgacatata catgtgaatg aaagacccca cctgtaggtt      420

tggcaagcta gcttaagtaa cgccattttg caaggcatgg aaaaatacat aactgagaat      480

agaaaagttc agatcaaggt caggaacaga tggaacagct gaatatgggc caaacaggat      540

atctgtggta agcagttcct gccccggctc agggccaaga acagatggaa cagctgaata      600

tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacaga      660

tggtccccag atgcggtcca gccctcagca gtttctagag aaccatcaga tgtttccagg      720

gtgccccaag gacctgaaat gaccctgtgc cttatttgaa ctaaccaatc agttcgcttc      780

tcgcttctgt tcgcgcgctt atgctccccg agctcaataa aagagcccac aacccctcac      840

tcggggcgcc agtcctccga ttgactgagt cgcccgggta cccgtgtatc caataaaccc      900

tcttgcagtt gcatccgact tgtggtctcg ctgttccttg ggagggtctc ctctgagtga      960

ttgactaccc gtcagcgggg gtctttcatt tgggggctcg tccgggatcg ggagacccct     1020

gcccagggac caccgaccca ccaccgggag gtaagctggc cagcaactta tctgtgtctg     1080

tccgattgtc tagtgtctat gactgatttt atgcgcctgc gtcggtacta gttagctaac     1140

tagctctgta tctggcggac ccgtggtgga actgacgagt tcggaacacc cggccgcaac     1200

cctgggagac gtcccaggga cttcgggggc cgtttttgtg gcccgacctg agtcctaaaa     1260

tcccgatcgt ttaggactct ttggtgcacc ccccttagag gagggatatg tggttctggt     1320

aggagacgag aacctaaaac agttcccgcc tccgtctgaa tttttgcttt cggtttggga     1380

ccgaagccgc gccgcgcgtc ttgtctgctg cagcatcgtt ctgtgttgtc tctgtctgac     1440

tgtgtttctg tatttgtctg aaaatatggg cccgggctag cctgttacca ctcccttaag     1500

tttgacctta ggtcactgga aagatgtcga gcggatcgct cacaaccagt cggtagatgt     1560

caagaagaga cgttgggtta ccttctgctc tgcagaatgg ccaaccttta acgtcggatg     1620

gccgcgagac ggcaccttta accgagacct catcacccag gttaagatca aggtcttttc     1680

acctggcccg catggacacc cagaccaggt ggggtacatc gtgacctggg aagccttggc     1740

ttttgacccc cctccctggg tcaagccctt tgtacaccct aagcctccgc ctcctcttcc     1800

tccatccgcc ccgtctctcc cccttgaacc tcctcgttcg accccgcctc gatcctccct     1860

ttatccagcc ctcactcctt ctctaggcgc ccccatatgg ccatatgaga tcttatatgg     1920

ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta ctaacagccc     1980

ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct ggagacctct     2040

ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt accgagtcgg     2100

cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct ggaaaggacc     2160

ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg cagcttggat     2220

acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta gactgccatg     2280

gaagcccctg cccagctgct gttcctgctg ctgctgtggc tgcccgacac caccggcgag     2340

atcgtgctga cacagagccc cgccaccctg tctctgagcc ctggcgagag agccaccctg     2400

agctgtagcg ccagcagcag catcaactac atctactggc tgcagcagaa gcccggccag     2460

gcccccagaa tcctgatcta cctgaccagc aacctggcca gcggcgtgcc cgccagattt     2520

tctggcagcg gcagcggcac cgacttcacc ctgaccatca gcagcctgga acccgaggac     2580

ttcgccgtgt actactgcct gcagtggtcc agcaaccccc tgaccttcgg cggaggcacc     2640

aaggtggaaa tcaagcgggg tggtggtggt tctggtggtg gtggttctga ggtgcagctg     2700

gtggaaagcg gcggaggcct ggtcaagcct ggcggcagcc tgagactgag ctgtgccgcc     2760

agcggcttca ccttcagcag ctacgacatg agctgggtcc gacaggctcc aggcaaggga     2820

ctggaatggg tgtccaccat cagcagcggc ggcagctaca cctactacct ggacagcatc     2880

aagggccggt tcaccatcag ccgggacaac gccaagaaca gcctgtacct gcagatgaac     2940

agcctgcggg ccgaggacac cgccgtctac tactgtgccc ggcagggcct cgactactgg     3000

ggcagaggca ccctggtcac cgtgtccagc ggggatccca aagaggcctg ccccaccggc     3060

ctgtacaccc acagcggaga gtgctgcaag gcctgcaacc tgggagaggg cgtggcccag     3120

ccttgcggcg ccaatcagac cgtgtgcgag ccctgcctgg acagcgtgac cttcagcgac     3180

gtggtgtccg ccaccgagcc ctgcaagcct tgcaccgagt gtgtgggcct gcagagcatg     3240

agcgccccct gcgtggaagc cgacgacgcc gtgtgtagat gcgcctacgg ctactaccag     3300

gacgagacaa ccggcagatg cgaggcctgt agagtgtgcg aggccggcag cggcctggtg     3360

ttcagttgtc aggacaagca gaacaccgtg tgtgaagagt gccccgacgg cacctacagc     3420

gacgaggcca accacgtgga cccctgcctg ccctgcactg tgtgcgagga caccgagcgg     3480

cagctgcgcg agtgcacaag atgggccgac gccgagtgcg aggaacccaa attttgggtg     3540

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt     3600

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact     3660

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc     3720

gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     3780

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     3840

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     3900

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     3960

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     4020

gccaccaagg acacctacga cgcccttcac atgcaggccc tgcctcctcg ctaagcatgc     4080

aacctcgatc cggattagtc caatttgtta aagacaggat atcagtggtc caggctctag     4140

ttttgactca acaatatcac cagctgaagc ctatagagta cgagccatag ataaaataaa     4200

agattttatt tagtctccag aaaaaggggg gaatgaaaga ccccacctgt aggtttggca     4260

agctagctta agtaacgcca ttttgcaagg catggaaaaa tacataactg agaatagaga     4320

agttcagatc aaggtcagga acagatggaa cagctgaata tgggccaaac aggatatctg     4380

tggtaagcag ttcctgcccc ggctcagggc caagaacaga tggaacagct gaatatgggc     4440

caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc     4500

cccagatgcg gtccagccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc     4560

ccaaggacct gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct     4620

tctgttcgcg cgcttctgct ccccgagctc aataaaagag cccacaaccc ctcactcggg     4680

gcgccagtcc tccgattgac tgagtcgccc gggtacccgt gtatccaata aaccctcttg     4740

cagttgcatc cgacttgtgg tctcgctgtt ccttgggagg gtctcctctg agtgattgac     4800

tacccgtcag cgggggtctt tcacacatgc agcatgtatc aaaattaatt tggttttttt     4860

tcttaagtat ttacattaaa tggccatagt acttaaagtt acattggctt ccttgaaata     4920

aacatggagt attcagaatg tgtcataaat atttctaatt ttaagatagt atctccattg     4980

gctttctact ttttctttta tttttttttg tcctctgtct tccatttgtt gttgttgttg     5040

tttgtttgtt tgtttgttgg ttggttggtt aatttttttt taaagatcct acactatagt     5100

tcaagctaga ctattagcta ctctgtaacc cagggtgacc ttgaagtcat gggtagcctg     5160

ctgttttagc cttcccacat ctaagattac aggtatgagc tatcattttt ggtatattga     5220

ttgattgatt gattgatgtg tgtgtgtgtg attgtgtttg tgtgtgtgac tgtgaaaatg     5280

tgtgtatggg tgtgtgtgaa tgtgtgtatg tatgtgtgtg tgtgagtgtg tgtgtgtgtg     5340

tgtgcatgtg tgtgtgtgtg actgtgtcta tgtgtatgac tgtgtgtgtg tgtgtgtgtg     5400

tgtgtgtgtg tgtgtgtgtg tgtgtgttgt gaaaaaatat tctatggtag tgagagccaa     5460

cgctccggct caggtgtcag gttggttttt gagacagagt ctttcactta gcttggaatt     5520

cactggccgt cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc caacttaatc     5580

gccttgcagc acatccccct ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc     5640

gcccttccca acagttgcgc agcctgaatg gcgaatggcg cctgatgcgg tattttctcc     5700

ttacgcatct gtgcggtatt tcacaccgca tatggtgcac tctcagtaca atctgctctg     5760

atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     5820

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     5880

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgatgac gaaagggcct cgtgatacgc     5940

ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt     6000

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat     6060

ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg     6120

agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt     6180

tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga     6240

gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa     6300

gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt     6360

attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt     6420

gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc     6480

agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga     6540

ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat     6600

cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct     6660

gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc     6720

cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg     6780

gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc     6840

ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg     6900

acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca     6960

ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta     7020

aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc     7080

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     7140

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     7200

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     7260

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     7320

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     7380

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     7440

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     7500

cgaacgacct acaccgaact gagataccta cagcgtgagc attgagaaag cgccacgctt     7560

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     7620

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     7680

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     7740

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc     7800

tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat     7860

accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag     7920

cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg cagctggcac     7980

gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt gagttagctc     8040

actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt     8100

gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc c              8151


<210>  39
<211>  8265
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD44v6-4GS2-CAR.28Z NGFR MUTATED LONG (V6 NML)

<400>  39
aagctttgct cttaggagtt tcctaataca tcccaaactc aaatatataa agcatttgac       60

ttgttctatg ccctaggggg cggggggaag ctaagccagc tttttttaac atttaaaatg      120

ttaattccat tttaaatgca cagatgtttt tatttcataa gggtttcaat gtgcatgaat      180

gctgcaatat tcctgttacc aaagctagta taaataaaaa tagataaacg tggaaattac      240

ttagagtttc tgtcattaac gtttccttcc tcagttgaca acataaatgc gctgctgagc      300

aagccagttt gcatctgtca ggatcaattt cccattatgc cagtcatatt aattactagt      360

caattagttg atttttattt ttgacatata catgtgaatg aaagacccca cctgtaggtt      420

tggcaagcta gcttaagtaa cgccattttg caaggcatgg aaaaatacat aactgagaat      480

agaaaagttc agatcaaggt caggaacaga tggaacagct gaatatgggc caaacaggat      540

atctgtggta agcagttcct gccccggctc agggccaaga acagatggaa cagctgaata      600

tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacaga      660

tggtccccag atgcggtcca gccctcagca gtttctagag aaccatcaga tgtttccagg      720

gtgccccaag gacctgaaat gaccctgtgc cttatttgaa ctaaccaatc agttcgcttc      780

tcgcttctgt tcgcgcgctt atgctccccg agctcaataa aagagcccac aacccctcac      840

tcggggcgcc agtcctccga ttgactgagt cgcccgggta cccgtgtatc caataaaccc      900

tcttgcagtt gcatccgact tgtggtctcg ctgttccttg ggagggtctc ctctgagtga      960

ttgactaccc gtcagcgggg gtctttcatt tgggggctcg tccgggatcg ggagacccct     1020

gcccagggac caccgaccca ccaccgggag gtaagctggc cagcaactta tctgtgtctg     1080

tccgattgtc tagtgtctat gactgatttt atgcgcctgc gtcggtacta gttagctaac     1140

tagctctgta tctggcggac ccgtggtgga actgacgagt tcggaacacc cggccgcaac     1200

cctgggagac gtcccaggga cttcgggggc cgtttttgtg gcccgacctg agtcctaaaa     1260

tcccgatcgt ttaggactct ttggtgcacc ccccttagag gagggatatg tggttctggt     1320

aggagacgag aacctaaaac agttcccgcc tccgtctgaa tttttgcttt cggtttggga     1380

ccgaagccgc gccgcgcgtc ttgtctgctg cagcatcgtt ctgtgttgtc tctgtctgac     1440

tgtgtttctg tatttgtctg aaaatatggg cccgggctag cctgttacca ctcccttaag     1500

tttgacctta ggtcactgga aagatgtcga gcggatcgct cacaaccagt cggtagatgt     1560

caagaagaga cgttgggtta ccttctgctc tgcagaatgg ccaaccttta acgtcggatg     1620

gccgcgagac ggcaccttta accgagacct catcacccag gttaagatca aggtcttttc     1680

acctggcccg catggacacc cagaccaggt ggggtacatc gtgacctggg aagccttggc     1740

ttttgacccc cctccctggg tcaagccctt tgtacaccct aagcctccgc ctcctcttcc     1800

tccatccgcc ccgtctctcc cccttgaacc tcctcgttcg accccgcctc gatcctccct     1860

ttatccagcc ctcactcctt ctctaggcgc ccccatatgg ccatatgaga tcttatatgg     1920

ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta ctaacagccc     1980

ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct ggagacctct     2040

ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt accgagtcgg     2100

cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct ggaaaggacc     2160

ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg cagcttggat     2220

acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta gactgccatg     2280

gaagcccctg cccagctgct gttcctgctg ctgctgtggc tgcccgacac caccggcgag     2340

atcgtgctga cacagagccc cgccaccctg tctctgagcc ctggcgagag agccaccctg     2400

agctgtagcg ccagcagcag catcaactac atctactggc tgcagcagaa gcccggccag     2460

gcccccagaa tcctgatcta cctgaccagc aacctggcca gcggcgtgcc cgccagattt     2520

tctggcagcg gcagcggcac cgacttcacc ctgaccatca gcagcctgga acccgaggac     2580

ttcgccgtgt actactgcct gcagtggtcc agcaaccccc tgaccttcgg cggaggcacc     2640

aaggtggaaa tcaagcgggg tggtggtggt tctggtggtg gtggttctga ggtgcagctg     2700

gtggaaagcg gcggaggcct ggtcaagcct ggcggcagcc tgagactgag ctgtgccgcc     2760

agcggcttca ccttcagcag ctacgacatg agctgggtcc gacaggctcc aggcaaggga     2820

ctggaatggg tgtccaccat cagcagcggc ggcagctaca cctactacct ggacagcatc     2880

aagggccggt tcaccatcag ccgggacaac gccaagaaca gcctgtacct gcagatgaac     2940

agcctgcggg ccgaggacac cgccgtctac tactgtgccc ggcagggcct cgactactgg     3000

ggcagaggca ccctggtcac cgtgtccagc ggggatccca aagaggcctg ccccaccggc     3060

ctgtacaccc acagcggaga gtgctgcaag gcctgcaacc tgggagaggg cgtggcccag     3120

ccttgcggcg ccaatcagac cgtgtgcgag ccctgcctgg acagcgtgac cttcagcgac     3180

gtggtgtccg ccaccgagcc ctgcaagcct tgcaccgagt gtgtgggcct gcagagcatg     3240

agcgccccct gcgtggaagc cgacgacgcc gtgtgtagat gcgcctacgg ctactaccag     3300

gacgagacaa ccggcagatg cgaggcctgt agagtgtgcg aggccggcag cggcctggtg     3360

ttcagttgtc aagacaagca gaataccgtg tgtgaagagt gccccgacgg cacctacagc     3420

gacgaagccg ccagagccgc cgacgccgag tgcgaagaga tccccggcag atggatcacc     3480

agaagcaccc cccctgaggg cagcgacagc accgccccta gcacccagga acctgaggcc     3540

cctcccgagc aggacctgat cgcctctaca gtggccggcg tggtgacaac cgtgatgggc     3600

agctctcagc ccgtggtgac acggggcacc accgacaatc ccaaattttg ggtgctggtg     3660

gtggttggtg gagtcctggc ttgctatagc ttgctagtaa cagtggcctt tattattttc     3720

tgggtgagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc     3780

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     3840

tatcgctcca gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     3900

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     3960

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     4020

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     4080

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     4140

aaggacacct acgacgccct tcacatgcag gccctgcctc ctcgctaagc atgcaacctc     4200

gatccggatt agtccaattt gttaaagaca ggatatcagt ggtccaggct ctagttttga     4260

ctcaacaata tcaccagctg aagcctatag agtacgagcc atagataaaa taaaagattt     4320

tatttagtct ccagaaaaag gggggaatga aagaccccac ctgtaggttt ggcaagctag     4380

cttaagtaac gccattttgc aaggcatgga aaaatacata actgagaata gagaagttca     4440

gatcaaggtc aggaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa     4500

gcagttcctg ccccggctca gggccaagaa cagatggaac agctgaatat gggccaaaca     4560

ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat ggtccccaga     4620

tgcggtccag ccctcagcag tttctagaga accatcagat gtttccaggg tgccccaagg     4680

acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct cgcttctgtt     4740

cgcgcgcttc tgctccccga gctcaataaa agagcccaca acccctcact cggggcgcca     4800

gtcctccgat tgactgagtc gcccgggtac ccgtgtatcc aataaaccct cttgcagttg     4860

catccgactt gtggtctcgc tgttccttgg gagggtctcc tctgagtgat tgactacccg     4920

tcagcggggg tctttcacac atgcagcatg tatcaaaatt aatttggttt tttttcttaa     4980

gtatttacat taaatggcca tagtacttaa agttacattg gcttccttga aataaacatg     5040

gagtattcag aatgtgtcat aaatatttct aattttaaga tagtatctcc attggctttc     5100

tactttttct tttatttttt tttgtcctct gtcttccatt tgttgttgtt gttgtttgtt     5160

tgtttgtttg ttggttggtt ggttaatttt tttttaaaga tcctacacta tagttcaagc     5220

tagactatta gctactctgt aacccagggt gaccttgaag tcatgggtag cctgctgttt     5280

tagccttccc acatctaaga ttacaggtat gagctatcat ttttggtata ttgattgatt     5340

gattgattga tgtgtgtgtg tgtgattgtg tttgtgtgtg tgactgtgaa aatgtgtgta     5400

tgggtgtgtg tgaatgtgtg tatgtatgtg tgtgtgtgag tgtgtgtgtg tgtgtgtgca     5460

tgtgtgtgtg tgtgactgtg tctatgtgta tgactgtgtg tgtgtgtgtg tgtgtgtgtg     5520

tgtgtgtgtg tgtgtgtgtg ttgtgaaaaa atattctatg gtagtgagag ccaacgctcc     5580

ggctcaggtg tcaggttggt ttttgagaca gagtctttca cttagcttgg aattcactgg     5640

ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg     5700

cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt     5760

cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc     5820

atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc tctgatgccg     5880

catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc     5940

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     6000

ggttttcacc gtcatcaccg aaacgcgcga tgacgaaagg gcctcgtgat acgcctattt     6060

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     6120

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     6180

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     6240

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     6300

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     6360

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     6420

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     6480

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     6540

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     6600

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     6660

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     6720

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     6780

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     6840

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     6900

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     6960

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     7020

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     7080

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     7140

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     7200

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     7260

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     7320

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     7380

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     7440

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     7500

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     7560

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     7620

acctacaccg aactgagata cctacagcgt gagcattgag aaagcgccac gcttcccgaa     7680

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     7740

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     7800

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     7860

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct     7920

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct     7980

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca     8040

atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg     8100

tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat     8160

taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc     8220

ggataacaat ttcacacagg aaacagctat gaccatgatt acgcc                     8265


<210>  40
<211>  8085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD44v6-4GS2-CAR.28Z NGFR MUTATED SHORT (V6 NMS)

<400>  40
aagctttgct cttaggagtt tcctaataca tcccaaactc aaatatataa agcatttgac       60

ttgttctatg ccctaggggg cggggggaag ctaagccagc tttttttaac atttaaaatg      120

ttaattccat tttaaatgca cagatgtttt tatttcataa gggtttcaat gtgcatgaat      180

gctgcaatat tcctgttacc aaagctagta taaataaaaa tagataaacg tggaaattac      240

ttagagtttc tgtcattaac gtttccttcc tcagttgaca acataaatgc gctgctgagc      300

aagccagttt gcatctgtca ggatcaattt cccattatgc cagtcatatt aattactagt      360

caattagttg atttttattt ttgacatata catgtgaatg aaagacccca cctgtaggtt      420

tggcaagcta gcttaagtaa cgccattttg caaggcatgg aaaaatacat aactgagaat      480

agaaaagttc agatcaaggt caggaacaga tggaacagct gaatatgggc caaacaggat      540

atctgtggta agcagttcct gccccggctc agggccaaga acagatggaa cagctgaata      600

tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacaga      660

tggtccccag atgcggtcca gccctcagca gtttctagag aaccatcaga tgtttccagg      720

gtgccccaag gacctgaaat gaccctgtgc cttatttgaa ctaaccaatc agttcgcttc      780

tcgcttctgt tcgcgcgctt atgctccccg agctcaataa aagagcccac aacccctcac      840

tcggggcgcc agtcctccga ttgactgagt cgcccgggta cccgtgtatc caataaaccc      900

tcttgcagtt gcatccgact tgtggtctcg ctgttccttg ggagggtctc ctctgagtga      960

ttgactaccc gtcagcgggg gtctttcatt tgggggctcg tccgggatcg ggagacccct     1020

gcccagggac caccgaccca ccaccgggag gtaagctggc cagcaactta tctgtgtctg     1080

tccgattgtc tagtgtctat gactgatttt atgcgcctgc gtcggtacta gttagctaac     1140

tagctctgta tctggcggac ccgtggtgga actgacgagt tcggaacacc cggccgcaac     1200

cctgggagac gtcccaggga cttcgggggc cgtttttgtg gcccgacctg agtcctaaaa     1260

tcccgatcgt ttaggactct ttggtgcacc ccccttagag gagggatatg tggttctggt     1320

aggagacgag aacctaaaac agttcccgcc tccgtctgaa tttttgcttt cggtttggga     1380

ccgaagccgc gccgcgcgtc ttgtctgctg cagcatcgtt ctgtgttgtc tctgtctgac     1440

tgtgtttctg tatttgtctg aaaatatggg cccgggctag cctgttacca ctcccttaag     1500

tttgacctta ggtcactgga aagatgtcga gcggatcgct cacaaccagt cggtagatgt     1560

caagaagaga cgttgggtta ccttctgctc tgcagaatgg ccaaccttta acgtcggatg     1620

gccgcgagac ggcaccttta accgagacct catcacccag gttaagatca aggtcttttc     1680

acctggcccg catggacacc cagaccaggt ggggtacatc gtgacctggg aagccttggc     1740

ttttgacccc cctccctggg tcaagccctt tgtacaccct aagcctccgc ctcctcttcc     1800

tccatccgcc ccgtctctcc cccttgaacc tcctcgttcg accccgcctc gatcctccct     1860

ttatccagcc ctcactcctt ctctaggcgc ccccatatgg ccatatgaga tcttatatgg     1920

ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta ctaacagccc     1980

ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct ggagacctct     2040

ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt accgagtcgg     2100

cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct ggaaaggacc     2160

ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg cagcttggat     2220

acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta gactgccatg     2280

gaagcccctg cccagctgct gttcctgctg ctgctgtggc tgcccgacac caccggcgag     2340

atcgtgctga cacagagccc cgccaccctg tctctgagcc ctggcgagag agccaccctg     2400

agctgtagcg ccagcagcag catcaactac atctactggc tgcagcagaa gcccggccag     2460

gcccccagaa tcctgatcta cctgaccagc aacctggcca gcggcgtgcc cgccagattt     2520

tctggcagcg gcagcggcac cgacttcacc ctgaccatca gcagcctgga acccgaggac     2580

ttcgccgtgt actactgcct gcagtggtcc agcaaccccc tgaccttcgg cggaggcacc     2640

aaggtggaaa tcaagcgggg tggtggtggt tctggtggtg gtggttctga ggtgcagctg     2700

gtggaaagcg gcggaggcct ggtcaagcct ggcggcagcc tgagactgag ctgtgccgcc     2760

agcggcttca ccttcagcag ctacgacatg agctgggtcc gacaggctcc aggcaaggga     2820

ctggaatggg tgtccaccat cagcagcggc ggcagctaca cctactacct ggacagcatc     2880

aagggccggt tcaccatcag ccgggacaac gccaagaaca gcctgtacct gcagatgaac     2940

agcctgcggg ccgaggacac cgccgtctac tactgtgccc ggcagggcct cgactactgg     3000

ggcagaggca ccctggtcac cgtgtccagc ggggatccca aagaggcctg ccccaccggc     3060

ctgtacaccc acagcggaga gtgctgcaag gcctgcaacc tgggagaggg cgtggcccag     3120

ccttgcggcg ccaatcagac cgtgtgcgag ccctgcctgg acagcgtgac cttcagcgac     3180

gtggtgtccg ccaccgagcc ctgcaagcct tgcaccgagt gtgtgggcct gcagagcatg     3240

agcgccccct gcgtggaagc cgacgacgcc gtgtgtagat gcgcctacgg ctactaccag     3300

gacgagacaa ccggcagatg cgaggcctgt agagtgtgcg aggccggcag cggcctggtg     3360

ttcagttgtc aggacaagca gaacaccgtg tgtgaagagt gccccgacgg cacctacagc     3420

gacgaggccg cccgggccgc cgacgccgag tgcgaggaac ccaaattttg ggtgctggtg     3480

gtggttggtg gagtcctggc ttgctatagc ttgctagtaa cagtggcctt tattattttc     3540

tgggtgagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc     3600

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     3660

tatcgctcca gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     3720

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     3780

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     3840

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     3900

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     3960

aaggacacct acgacgccct tcacatgcag gccctgcctc ctcgctaagc atgcaacctc     4020

gatccggatt agtccaattt gttaaagaca ggatatcagt ggtccaggct ctagttttga     4080

ctcaacaata tcaccagctg aagcctatag agtacgagcc atagataaaa taaaagattt     4140

tatttagtct ccagaaaaag gggggaatga aagaccccac ctgtaggttt ggcaagctag     4200

cttaagtaac gccattttgc aaggcatgga aaaatacata actgagaata gagaagttca     4260

gatcaaggtc aggaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa     4320

gcagttcctg ccccggctca gggccaagaa cagatggaac agctgaatat gggccaaaca     4380

ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat ggtccccaga     4440

tgcggtccag ccctcagcag tttctagaga accatcagat gtttccaggg tgccccaagg     4500

acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct cgcttctgtt     4560

cgcgcgcttc tgctccccga gctcaataaa agagcccaca acccctcact cggggcgcca     4620

gtcctccgat tgactgagtc gcccgggtac ccgtgtatcc aataaaccct cttgcagttg     4680

catccgactt gtggtctcgc tgttccttgg gagggtctcc tctgagtgat tgactacccg     4740

tcagcggggg tctttcacac atgcagcatg tatcaaaatt aatttggttt tttttcttaa     4800

gtatttacat taaatggcca tagtacttaa agttacattg gcttccttga aataaacatg     4860

gagtattcag aatgtgtcat aaatatttct aattttaaga tagtatctcc attggctttc     4920

tactttttct tttatttttt tttgtcctct gtcttccatt tgttgttgtt gttgtttgtt     4980

tgtttgtttg ttggttggtt ggttaatttt tttttaaaga tcctacacta tagttcaagc     5040

tagactatta gctactctgt aacccagggt gaccttgaag tcatgggtag cctgctgttt     5100

tagccttccc acatctaaga ttacaggtat gagctatcat ttttggtata ttgattgatt     5160

gattgattga tgtgtgtgtg tgtgattgtg tttgtgtgtg tgactgtgaa aatgtgtgta     5220

tgggtgtgtg tgaatgtgtg tatgtatgtg tgtgtgtgag tgtgtgtgtg tgtgtgtgca     5280

tgtgtgtgtg tgtgactgtg tctatgtgta tgactgtgtg tgtgtgtgtg tgtgtgtgtg     5340

tgtgtgtgtg tgtgtgtgtg ttgtgaaaaa atattctatg gtagtgagag ccaacgctcc     5400

ggctcaggtg tcaggttggt ttttgagaca gagtctttca cttagcttgg aattcactgg     5460

ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg     5520

cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt     5580

cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc     5640

atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc tctgatgccg     5700

catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc     5760

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     5820

ggttttcacc gtcatcaccg aaacgcgcga tgacgaaagg gcctcgtgat acgcctattt     5880

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     5940

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     6000

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     6060

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     6120

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     6180

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     6240

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     6300

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     6360

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     6420

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     6480

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     6540

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     6600

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     6660

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     6720

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     6780

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     6840

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     6900

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     6960

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     7020

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     7080

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     7140

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     7200

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     7260

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     7320

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     7380

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     7440

acctacaccg aactgagata cctacagcgt gagcattgag aaagcgccac gcttcccgaa     7500

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     7560

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     7620

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     7680

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct     7740

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct     7800

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca     7860

atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg     7920

tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat     7980

taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc     8040

ggataacaat ttcacacagg aaacagctat gaccatgatt acgcc                     8085


