                               SEQUENCE LISTING

<110> SYMPHOGEN A/S
 
<120> ANTI-MET ANTIBODIES AND COMPOSITIONS

<130> 110285-0051-WO1

<140>
<141>

<150> 62/051,190
<151> 2014-09-16

<160> 39    

<170> PatentIn version 3.5

<210> 1
<211> 1390
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210> 2
<211> 1408
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu 
        755                 760                 765             


Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn 
    770                 775                 780                 


Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala 
785                 790                 795                 800 


Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile 
                805                 810                 815     


Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro 
            820                 825                 830         


Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr 
        835                 840                 845             


Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys 
    850                 855                 860                 


Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly 
865                 870                 875                 880 


Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly 
                885                 890                 895     


Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys 
            900                 905                 910         


Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu 
        915                 920                 925             


Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln 
    930                 935                 940                 


Pro Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser 
945                 950                 955                 960 


Thr Ala Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg 
                965                 970                 975     


Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg 
            980                 985                 990         


Val His Thr Pro His Leu Asp Arg  Leu Val Ser Ala Arg  Ser Val Ser 
        995                 1000                 1005             


Pro Thr  Thr Glu Met Val Ser  Asn Glu Ser Val Asp  Tyr Arg Ala 
    1010                 1015                 1020             


Thr Phe  Pro Glu Asp Gln Phe  Pro Asn Ser Ser Gln  Asn Gly Ser 
    1025                 1030                 1035             


Cys Arg  Gln Val Gln Tyr Pro  Leu Thr Asp Met Ser  Pro Ile Leu 
    1040                 1045                 1050             


Thr Ser  Gly Asp Ser Asp Ile  Ser Ser Pro Leu Leu  Gln Asn Thr 
    1055                 1060                 1065             


Val His  Ile Asp Leu Ser Ala  Leu Asn Pro Glu Leu  Val Gln Ala 
    1070                 1075                 1080             


Val Gln  His Val Val Ile Gly  Pro Ser Ser Leu Ile  Val His Phe 
    1085                 1090                 1095             


Asn Glu  Val Ile Gly Arg Gly  His Phe Gly Cys Val  Tyr His Gly 
    1100                 1105                 1110             


Thr Leu  Leu Asp Asn Asp Gly  Lys Lys Ile His Cys  Ala Val Lys 
    1115                 1120                 1125             


Ser Leu  Asn Arg Ile Thr Asp  Ile Gly Glu Val Ser  Gln Phe Leu 
    1130                 1135                 1140             


Thr Glu  Gly Ile Ile Met Lys  Asp Phe Ser His Pro  Asn Val Leu 
    1145                 1150                 1155             


Ser Leu  Leu Gly Ile Cys Leu  Arg Ser Glu Gly Ser  Pro Leu Val 
    1160                 1165                 1170             


Val Leu  Pro Tyr Met Lys His  Gly Asp Leu Arg Asn  Phe Ile Arg 
    1175                 1180                 1185             


Asn Glu  Thr His Asn Pro Thr  Val Lys Asp Leu Ile  Gly Phe Gly 
    1190                 1195                 1200             


Leu Gln  Val Ala Lys Gly Met  Lys Tyr Leu Ala Ser  Lys Lys Phe 
    1205                 1210                 1215             


Val His  Arg Asp Leu Ala Ala  Arg Asn Cys Met Leu  Asp Glu Lys 
    1220                 1225                 1230             


Phe Thr  Val Lys Val Ala Asp  Phe Gly Leu Ala Arg  Asp Met Tyr 
    1235                 1240                 1245             


Asp Lys  Glu Tyr Tyr Ser Val  His Asn Lys Thr Gly  Ala Lys Leu 
    1250                 1255                 1260             


Pro Val  Lys Trp Met Ala Leu  Glu Ser Leu Gln Thr  Gln Lys Phe 
    1265                 1270                 1275             


Thr Thr  Lys Ser Asp Val Trp  Ser Phe Gly Val Leu  Leu Trp Glu 
    1280                 1285                 1290             


Leu Met  Thr Arg Gly Ala Pro  Pro Tyr Pro Asp Val  Asn Thr Phe 
    1295                 1300                 1305             


Asp Ile  Thr Val Tyr Leu Leu  Gln Gly Arg Arg Leu  Leu Gln Pro 
    1310                 1315                 1320             


Glu Tyr  Cys Pro Asp Pro Leu  Tyr Glu Val Met Leu  Lys Cys Trp 
    1325                 1330                 1335             


His Pro  Lys Ala Glu Met Arg  Pro Ser Phe Ser Glu  Leu Val Ser 
    1340                 1345                 1350             


Arg Ile  Ser Ala Ile Phe Ser  Thr Phe Ile Gly Glu  His Tyr Val 
    1355                 1360                 1365             


His Val  Asn Ala Thr Tyr Val  Asn Val Lys Cys Val  Ala Pro Tyr 
    1370                 1375                 1380             


Pro Ser  Leu Leu Ser Ser Glu  Asp Asn Ala Asp Asp  Glu Val Asp 
    1385                 1390                 1395             


Thr Arg  Pro Ala Ser Phe Trp  Glu Thr Ser 
    1400                 1405             


<210> 3
<211> 1382
<212> PRT
<213> Gallus gallus

<400> 3
Met Lys Pro Val Thr Ala Tyr Pro Ser Gly Ile Ile Leu Phe Leu Phe 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser His Gly Gln Cys Lys Glu Ala Ala Lys Lys 
            20                  25                  30          


Ser Glu Met Asn Leu Asn Val Lys Tyr Asp Leu Pro Asn Phe Ile Thr 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Val Leu Tyr Lys His His Val Tyr Ile 
    50                  55                  60                  


Gly Ala Val Asn Lys Ile Tyr Val Leu Asn Glu Thr Leu Gln Asn Ile 
65                  70                  75                  80  


Ser Val Tyr Lys Thr Gly Pro Ile Leu Glu Ser Pro Gly Cys Ala Pro 
                85                  90                  95      


Cys Glu Asp Cys Lys Asp Lys Ala Asn Leu Ser Asn Ser Val Trp Lys 
            100                 105                 110         


Asp Asn Val Asn Met Ala Leu Leu Leu Glu Thr Tyr Tyr Asp Asp Gln 
        115                 120                 125             


Leu Ile Ser Cys Gly Ser Val Ser Gly Gly Val Cys His Arg His Ile 
    130                 135                 140                 


Ile Pro Pro Asp Asn Pro Ala Asp Ile Glu Ser Glu Val His Cys Met 
145                 150                 155                 160 


Tyr Ser Pro Gln Val Asp Gly Glu Ala Asp Asn Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Thr Leu Gly Thr Lys Val Leu Val Thr Glu Lys Asp Arg Phe 
            180                 185                 190         


Val Asn Phe Phe Val Gly Asn Thr Met Thr Ser Ala Phe Gln Pro Pro 
        195                 200                 205             


His Val Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Gln Asp 
    210                 215                 220                 


Gly Phe Glu Phe Leu Thr Asp Gln Ser Tyr Ile Asp Ile Leu Pro Gln 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu His Asp 
                245                 250                 255     


His Phe Val Tyr Phe Leu Thr Val Gln Arg Glu Ser Leu Asp Ser Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Thr Leu Asp Ser Glu Met 
        275                 280                 285             


Arg Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Phe Thr Glu Lys Arg 
    290                 295                 300                 


Arg Lys Arg Ser Ile Arg Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Ala Leu Ala His Glu Met Gly Leu Gly 
                325                 330                 335     


Leu Ile Asp Asp Ile Leu Tyr Gly Val Phe Ala Gln Thr Asn Gln Ile 
            340                 345                 350         


Pro Gln Glu Pro Thr Asn Arg Ser Ala Val Cys Ala Val Ser Val Arg 
        355                 360                 365             


Thr Ile Asn Glu Phe Phe Asn Lys Ile Val Asp Lys Gln Asn Met Lys 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Lys Asp Ser Lys Tyr Cys Leu Asn Arg 
385                 390                 395                 400 


Ala Phe Ser Arg Asn Ala Ser Tyr Cys Arg Ala Gln Asp Asp Glu Tyr 
                405                 410                 415     


Arg Leu Glu Val Thr Thr Pro Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Asn Asn Ile Leu Leu Thr Ser Ile Ser Val Phe Thr Lys Gly 
        435                 440                 445             


Asn Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Ile Val Val Ser Arg Ser Glu Pro Thr Ala Pro His Val Ser Phe Gln 
465                 470                 475                 480 


Leu Asp Ser His Ala Val Ser Pro Gln Val Val Val Glu Gln Ser Ala 
                485                 490                 495     


Ala Ala Asp Gly Tyr Thr Leu Val Val Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Val Pro Leu Asn Gly Pro Gly Cys His His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Leu Ala Pro Ala Phe Met Arg Cys Gly Trp Cys Gly Gln Gln 
    530                 535                 540                 


Cys Leu Arg Ala Pro Glu Cys Asn Gly Gly Thr Trp Thr Gln Glu Thr 
545                 550                 555                 560 


Cys Leu Pro Arg Val Tyr Glu Ile Leu Pro Ser Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Lys Leu Thr Leu Cys Gly Trp Asp Phe Gly Phe Ser Lys 
            580                 585                 590         


Asn Asn Arg Phe Glu Leu Arg Asn Thr Val Val His Ile Gly Gly Gln 
        595                 600                 605             


Ile Cys Ala Leu Glu Ala Lys Ser Ser Asn Lys Asn Lys Leu Glu Cys 
    610                 615                 620                 


Thr Ala Pro Ala Ala Lys Asn Ala Ser Phe Asn Ile Ser Ser Ser Val 
625                 630                 635                 640 


Ser Val Gly His Gly Lys Thr Leu Phe Asn Thr Phe Ser Tyr Val Asn 
                645                 650                 655     


Pro Ile Ile Thr Ser Ile Ser Pro Thr Tyr Gly Pro Lys Ser Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Ile Ala Gly Lys Tyr Leu Asn Ser Gly Lys Ser Arg 
        675                 680                 685             


Arg Ile Phe Val Gly Glu Lys Pro Cys Ser Leu Lys Ser Thr Ser Glu 
    690                 695                 700                 


Ser Ser Val Glu Cys Tyr Thr Pro Ala Gln Arg Ile Pro Gln Glu Tyr 
705                 710                 715                 720 


Arg Val Arg Val Gly Ile Asp Gly Ala Ile Arg Asp Ala Lys Gly Tyr 
                725                 730                 735     


Phe Thr Tyr Arg Glu Asp Pro Val Val Leu Lys Ile His Pro Ala Lys 
            740                 745                 750         


Ser Phe Leu Ser Gly Gly Ser Thr Ile Thr Ala Gln Gly Ile Asn Leu 
        755                 760                 765             


Asn Ser Val Cys Phe Pro Arg Met Val Ile Thr Val Pro Lys Leu Gly 
    770                 775                 780                 


Met Asn Phe Ser Val Ala Cys Ser His Arg Ser Ser Ser Glu Ile Ile 
785                 790                 795                 800 


Cys Cys Thr Thr Pro Ser Leu Lys Ala Phe Asn Leu Gln Pro Pro Phe 
                805                 810                 815     


Val Thr Lys Val Phe Phe Ile Phe Asp Gly Val Ser Ser Leu Tyr Phe 
            820                 825                 830         


Asp Phe Asp Tyr Val Asn Asn Pro Val Phe Lys His Phe Glu Lys Pro 
        835                 840                 845             


Val Leu Ile Ser Arg Ser Asn Pro Asn Val Leu Glu Ile Lys Gly Asn 
    850                 855                 860                 


His Ile Asp Ser Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn 
865                 870                 875                 880 


Lys Ser Cys Glu Asn Leu Leu Leu Gln Ser Glu Thr Ile Leu Cys Thr 
                885                 890                 895     


Val Pro Ser Asp Leu Leu Lys Ser Asn Ser Glu Leu Asn Ile Glu Trp 
            900                 905                 910         


Lys Gln Glu Val Leu Ser Thr Val Ile Gly Lys Val Leu Ile Arg Gln 
        915                 920                 925             


Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Thr Ser Val 
    930                 935                 940                 


Leu Ile Tyr Ile Phe Leu Val Phe Phe Leu Trp Arg Arg Lys Lys Lys 
945                 950                 955                 960 


Gln Ile Lys Asp Leu Gly Ser Asp Leu Val Arg Tyr Asp Gly Arg Val 
                965                 970                 975     


His Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro 
            980                 985                 990         


Thr Thr Glu Met Val Ser Ser Glu  Ser Val Asp Tyr Arg  Ser Thr Phe 
        995                 1000                 1005             


Leu Glu  Asp Gln Phe Pro Ser  Met Ser Gln Asn Gly  Ser Cys Arg 
    1010                 1015                 1020             


Pro Ala  Gln Tyr Pro His Ser  Asp Leu Ser Pro Ile  Leu Ser Ser 
    1025                 1030                 1035             


Gly Asp  Ser Asp Leu Ala Ser  Pro Leu Leu Gln Thr  Asn Val His 
    1040                 1045                 1050             


Ile Asp  Ile Ser Ala Leu Asn  Pro Asp Leu Val Lys  Glu Val Gln 
    1055                 1060                 1065             


His Val  Val Ile Gly Ala Asp  Ser Leu Met Val His  Phe Ser Glu 
    1070                 1075                 1080             


Val Ile  Gly Arg Gly His Phe  Gly Cys Val Ser His  Gly Thr Leu 
    1085                 1090                 1095             


Leu Asp  Asn Asp Gly Arg Lys  Ile His Cys Ala Val  Lys Ser Leu 
    1100                 1105                 1110             


Asn Arg  Ile Thr Asp Leu Glu  Glu Val Ala Gln Phe  Leu Lys Glu 
    1115                 1120                 1125             


Gly Ile  Ile Met Lys Asp Phe  Thr His Pro Asn Val  Leu Ser Leu 
    1130                 1135                 1140             


Leu Gly  Ile Cys Leu Pro Asn  Glu Gly Ser Pro Leu  Val Val Leu 
    1145                 1150                 1155             


Pro Tyr  Met Lys His Gly Asp  Leu Arg Asn Phe Ile  Arg Asn Glu 
    1160                 1165                 1170             


Thr His  Asn Pro Thr Val Lys  Asp Leu Ile Gly Phe  Gly Leu Gln 
    1175                 1180                 1185             


Val Ala  Lys Gly Met Lys Tyr  Leu Ala Ser Lys Lys  Phe Val His 
    1190                 1195                 1200             


Arg Asp  Leu Ala Ala Arg Asn  Cys Met Leu Asp Glu  Lys Phe Thr 
    1205                 1210                 1215             


Val Lys  Val Ala Asp Phe Gly  Leu Ala Arg Asp Val  Tyr Asp Lys 
    1220                 1225                 1230             


Glu Tyr  Tyr Ser Val His Asn  Lys Thr Gly Ala Lys  Leu Pro Val 
    1235                 1240                 1245             


Lys Trp  Met Ala Leu Glu Ser  Leu Gln Thr Gln Lys  Phe Thr Thr 
    1250                 1255                 1260             


Lys Ser  Asp Val Trp Ser Phe  Gly Val Leu Leu Trp  Glu Leu Met 
    1265                 1270                 1275             


Thr Arg  Gly Ala Pro Pro Tyr  Pro Asp Val Asn Ser  Phe Asp Ile 
    1280                 1285                 1290             


Thr Val  Tyr Leu Leu Gln Gly  Arg Arg Leu Leu Gln  Pro Glu Tyr 
    1295                 1300                 1305             


Cys Pro  Asp Pro Leu Tyr Glu  Val Met Leu Lys Cys  Trp His Pro 
    1310                 1315                 1320             


Lys Pro  Glu Met Arg Pro Ala  Phe Ser Glu Leu Val  Ser Lys Ile 
    1325                 1330                 1335             


Ser Thr  Ile Phe Ser Thr Phe  Ile Gly Glu His Tyr  Val His Val 
    1340                 1345                 1350             


Asn Ala  Thr Tyr Val Asn Val  Lys Cys Val Ala Pro  Tyr Pro Ser 
    1355                 1360                 1365             


Leu Leu  Ser Ser Gln Asp Asn  Thr Asp Met Asp Val  Asp Thr 
    1370                 1375                 1380         


<210> 4
<211> 1379
<212> PRT
<213> Mus musculus

<400> 4
Met Lys Ala Pro Thr Val Leu Ala Pro Gly Ile Leu Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Gln Arg Ser His Gly Glu Cys Lys Glu Ala Leu Val Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Val Leu His Gly His His Ile Tyr Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Asp Lys Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ser Glu Phe Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Leu 
                85                  90                  95      


Pro Cys Arg Asp Cys Ser Ser Lys Ala Asn Ser Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Leu Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Leu Pro Pro Asp Asn Ser Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Met Phe Ser Pro Glu Glu Glu Ser Gly Gln Cys Pro Asp Cys Val Val 
                165                 170                 175     


Ser Ala Leu Gly Ala Lys Val Leu Leu Ser Glu Lys Asp Arg Phe Ile 
            180                 185                 190         


Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Pro Pro Gly Tyr 
        195                 200                 205             


Ser Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Gln Asp Gly 
    210                 215                 220                 


Phe Lys Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu Phe 
225                 230                 235                 240 


Gln Asp Ser Tyr Pro Ile Lys Tyr Ile His Ala Phe Glu Ser Asn His 
                245                 250                 255     


Phe Ile Tyr Phe Leu Thr Val Gln Lys Glu Thr Leu Asp Ala Gln Thr 
            260                 265                 270         


Phe His Thr Arg Ile Ile Arg Phe Cys Ser Val Asp Ser Gly Leu His 
        275                 280                 285             


Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg Arg 
    290                 295                 300                 


Lys Arg Ser Thr Arg Glu Glu Val Phe Asn Ile Leu Gln Ala Ala Tyr 
305                 310                 315                 320 


Val Ser Lys Pro Gly Ala Asn Leu Ala Lys Gln Ile Gly Ala Ser Pro 
                325                 330                 335     


Ser Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp Ser 
            340                 345                 350         


Ala Glu Pro Val Asn Arg Ser Ala Val Cys Ala Phe Pro Ile Lys Tyr 
        355                 360                 365             


Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg Cys 
    370                 375                 380                 


Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg Thr 
385                 390                 395                 400 


Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Ser Asp Glu Tyr Arg 
                405                 410                 415     


Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly Arg 
            420                 425                 430         


Leu Asn Gln Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly Asp 
        435                 440                 445             


Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln Val 
    450                 455                 460                 


Val Leu Ser Arg Thr Ala His Leu Thr Pro His Val Asn Phe Leu Leu 
465                 470                 475                 480 


Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Pro Ser Asn 
                485                 490                 495     


Gln Asn Gly Tyr Thr Leu Val Val Thr Gly Lys Lys Ile Thr Lys Ile 
            500                 505                 510         


Pro Leu Asn Gly Leu Gly Cys Gly His Phe Gln Ser Cys Ser Gln Cys 
        515                 520                 525             


Leu Ser Ala Pro Tyr Phe Ile Gln Cys Gly Trp Cys His Asn Gln Cys 
    530                 535                 540                 


Val Arg Phe Asp Glu Cys Pro Ser Gly Thr Trp Thr Gln Glu Ile Cys 
545                 550                 555                 560 


Leu Pro Ala Val Tyr Lys Val Phe Pro Thr Ser Ala Pro Leu Glu Gly 
                565                 570                 575     


Gly Thr Val Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Lys Asn 
            580                 585                 590         


Asn Lys Phe Asp Leu Arg Lys Thr Lys Val Leu Leu Gly Asn Glu Ser 
        595                 600                 605             


Cys Thr Leu Thr Leu Ser Glu Ser Thr Thr Asn Thr Leu Lys Cys Thr 
    610                 615                 620                 


Val Gly Pro Ala Met Ser Glu His Phe Asn Val Ser Val Ile Ile Ser 
625                 630                 635                 640 


Asn Ser Arg Glu Thr Thr Gln Tyr Ser Ala Phe Ser Tyr Val Asp Pro 
                645                 650                 655     


Val Ile Thr Ser Ile Ser Pro Arg Tyr Gly Pro Gln Ala Gly Gly Thr 
            660                 665                 670         


Leu Leu Thr Leu Thr Gly Lys Tyr Leu Asn Ser Gly Asn Ser Arg His 
        675                 680                 685             


Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asp Ser 
    690                 695                 700                 


Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Thr Ser Asp Glu Phe Pro 
705                 710                 715                 720 


Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ser Phe Ser 
                725                 730                 735     


Tyr Arg Glu Asp Pro Val Val Tyr Glu Ile His Pro Thr Lys Ser Phe 
            740                 745                 750         


Ile Ser Gly Gly Ser Thr Ile Thr Gly Ile Gly Lys Thr Leu Asn Ser 
        755                 760                 765             


Val Ser Leu Pro Lys Leu Val Ile Asp Val His Glu Val Gly Val Asn 
    770                 775                 780                 


Tyr Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys Cys 
785                 790                 795                 800 


Thr Thr Pro Ser Leu Lys Gln Leu Gly Leu Gln Leu Pro Leu Lys Thr 
                805                 810                 815     


Lys Ala Phe Phe Leu Leu Asp Gly Ile Leu Ser Lys His Phe Asp Leu 
            820                 825                 830         


Thr Tyr Val His Asn Pro Val Phe Glu Pro Phe Glu Lys Pro Val Met 
        835                 840                 845             


Ile Ser Ile Gly Asn Glu Asn Val Val Glu Ile Lys Gly Asn Asn Ile 
    850                 855                 860                 


Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Gln Ser 
865                 870                 875                 880 


Cys Glu Ser Leu His Trp His Ser Gly Ala Val Leu Cys Thr Val Pro 
                885                 890                 895     


Ser Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys Gln 
            900                 905                 910         


Ala Val Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp Gln 
        915                 920                 925             


Asn Phe Ala Gly Leu Ile Ile Gly Ala Val Ser Ile Ser Val Val Val 
    930                 935                 940                 


Leu Leu Leu Ser Gly Leu Phe Leu Trp Met Arg Lys Arg Lys His Lys 
945                 950                 955                 960 


Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His Thr Pro 
                965                 970                 975     


His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr Thr Glu 
            980                 985                 990         


Met Val Ser Asn Glu Ser Val Asp  Tyr Arg Ala Thr Phe  Pro Glu Asp 
        995                 1000                 1005             


Gln Phe  Pro Asn Ser Ser Gln  Asn Gly Ala Cys Arg  Gln Val Gln 
    1010                 1015                 1020             


Tyr Pro  Leu Thr Asp Leu Ser  Pro Ile Leu Thr Ser  Gly Asp Ser 
    1025                 1030                 1035             


Asp Ile  Ser Ser Pro Leu Leu  Gln Asn Thr Val His  Ile Asp Leu 
    1040                 1045                 1050             


Ser Ala  Leu Asn Pro Glu Leu  Val Gln Ala Val Gln  His Val Val 
    1055                 1060                 1065             


Ile Gly  Pro Ser Ser Leu Ile  Val His Phe Asn Glu  Val Ile Gly 
    1070                 1075                 1080             


Arg Gly  His Phe Gly Cys Val  Tyr His Gly Thr Leu  Leu Asp Asn 
    1085                 1090                 1095             


Asp Gly  Lys Lys Ile His Cys  Ala Val Lys Ser Leu  Asn Arg Ile 
    1100                 1105                 1110             


Thr Asp  Ile Glu Glu Val Ser  Gln Phe Leu Thr Glu  Gly Ile Ile 
    1115                 1120                 1125             


Met Lys  Asp Phe Ser His Pro  Asn Val Leu Ser Leu  Leu Gly Ile 
    1130                 1135                 1140             


Cys Leu  Arg Ser Glu Gly Ser  Pro Leu Val Val Leu  Pro Tyr Met 
    1145                 1150                 1155             


Lys His  Gly Asp Leu Arg Asn  Phe Ile Arg Asn Glu  Thr His Asn 
    1160                 1165                 1170             


Pro Thr  Val Lys Asp Leu Ile  Gly Phe Gly Leu Gln  Val Ala Lys 
    1175                 1180                 1185             


Gly Met  Lys Tyr Leu Ala Ser  Lys Lys Phe Val His  Arg Asp Leu 
    1190                 1195                 1200             


Ala Ala  Arg Asn Cys Met Leu  Asp Glu Lys Phe Thr  Val Lys Val 
    1205                 1210                 1215             


Ala Asp  Phe Gly Leu Ala Arg  Asp Met Tyr Asp Lys  Glu Tyr Tyr 
    1220                 1225                 1230             


Ser Val  His Asn Lys Thr Gly  Ala Lys Leu Pro Val  Lys Trp Met 
    1235                 1240                 1245             


Ala Leu  Glu Ser Leu Gln Thr  Gln Lys Phe Thr Thr  Lys Ser Asp 
    1250                 1255                 1260             


Val Trp  Ser Phe Gly Val Leu  Leu Trp Glu Leu Met  Thr Arg Gly 
    1265                 1270                 1275             


Ala Pro  Pro Tyr Pro Asp Val  Asn Thr Phe Asp Ile  Thr Ile Tyr 
    1280                 1285                 1290             


Leu Leu  Gln Gly Arg Arg Leu  Leu Gln Pro Glu Tyr  Cys Pro Asp 
    1295                 1300                 1305             


Ala Leu  Tyr Glu Val Met Leu  Lys Cys Trp His Pro  Lys Ala Glu 
    1310                 1315                 1320             


Met Arg  Pro Ser Phe Ser Glu  Leu Val Ser Arg Ile  Ser Ser Ile 
    1325                 1330                 1335             


Phe Ser  Thr Phe Ile Gly Glu  His Tyr Val His Val  Asn Ala Thr 
    1340                 1345                 1350             


Tyr Val  Asn Val Lys Cys Val  Ala Pro Tyr Pro Ser  Leu Leu Pro 
    1355                 1360                 1365             


Ser Gln  Asp Asn Ile Asp Gly  Glu Gly Asn Thr 
    1370                 1375                 


<210> 5
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
cagatccatt tggggcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactttagaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gttgatgact tgaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aaggaaaggg      300

attgcgaggg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc gagt            354


<210> 6
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Gln Ile His Leu Gly Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Arg Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Gly Ile Ala Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210> 7
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 7
aacattgtga tgacacagtc tccatcctcc ctgagtgtgt cagcaggaga gatggtcact       60

atgagttgta agtccagtca gagtctgtta gacagtggaa atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagcctcct caacttttga tcttcggggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      240

gtcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      300

ccgtacacgt tcggaggggg gaccaagctg gaaataaaa                             339


<210> 8
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Asn Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Met Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Gln Leu Leu Ile Phe Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Val Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 9
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 9
caggtccaac tgcaacagcc tggggctgaa ctggcaaaac ctggggcctc agtgaggatg       60

tcctgcaagg cttctggcta cacctttact agttactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gcagtggtca tattgagaac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atttgaggac tctgcagtct attactgtgc aagaggacgg      300

tttgcttact ggggccaagg gactctggtc actgtctcga gt                         342


<210> 10
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly His Ile Glu Asn Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 11
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
gatattgtga tgacccagtc tccagcaatc atgtctgcat ctcctgggga gaaggtcacc       60

ttgacctgca gtgccagctc aagtgtaagt tccggctact tgtactggta ccagcagaag      120

ccaggatcct cccccaaact ctggatttat agcacatcca acctggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacagtcaa cagcatggag      240

gctgaagatg ctgcctctta tttctgccat cagtggagta gttacccatt cacgttcggc      300

tcggggacca agctggagct gaaa                                             324


<210> 12
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val Asn Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210> 13
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 13
caggtgcagc tggtgcagtc tggatccgag ctgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cttccggcta cacctttacc aacttccgga tgaactgggt caagcaggcc      120

ccaggccagg gcctgaaatg gatgggctgg atcaacacct acaccggcga gcccacctac      180

gtggacgacc tgaagggcag attcgtgttc tccctggaca cctccgtgtc caccgcctac      240

ctgcagatct ccagcctgaa ggccgaggat accgccgtgt actactgcgc ccggaaggga      300

atcgccagag ccatggatta ttggggccag ggcaccaccg tgacagtctc gagt            354


<210> 14
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Arg Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ile Ala Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210> 15
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 15
gacatcgtga tgacccagtc ccccgactct ctggccgtgt ctctgggcga gagagccacc       60

atcaactgca agtcctccca gtccctgctg gactccggca accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagcctccc aagctgctga tctttggcgc ctccacccgg      180

gaatctggcg tgcccgatag attctccggc tccggctctg gcaccgactt taccctgacc      240

atcagctccc tgcaggccga ggatgtggcc gtgtactact gccagaacga ccactcctac      300

ccctacacct tcggccaggg caccaagctg gaaatcaag                             339


<210> 16
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 17
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
caggtgcagc tggtgcagtc tggcgctgaa gtgaagaaac ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta cacctttacc agctactgga tgcactgggt gcgacaggcc      120

cctggacagg gcctggaatg gatgggctac atcaacccct ccagcggcca catcgagaac      180

aaccagaaat tcaaggaccg cgtgaccatc accgccgaca agtccacctc caccgcctac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgtgc cagaggcaga      300

ttcgcctact ggggccaggg caccctcgtg acagtctcga gt                         342


<210> 18
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly His Ile Glu Asn Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 19
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 19
gagatcgtgc tgacccagtc tcctgccacc ctgtctctga gccctggcga gagagctacc       60

ctgtcctgct ccgcctcctc ctctgtgtcc tccggctacc tgtactggta tcagcagaag      120

cccggccagg cccctcggct gctgatctac tctacctcca acctggcctc cggcatccct      180

gccagattct ccggctctgg ctctggcacc gactttaccc tgaccatctc cagcctggaa      240

cccgaggact tcgccgtgta ctactgccac cagtggtcca gctacccctt cacctttggc      300

tccggcacca agctggaaat caag                                             324


<210> 20
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Gly Tyr Thr Phe Thr Asn Phe Arg 
1               5               


<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Ala Arg Lys Gly Ile Ala Arg Ala Met Asp Tyr 
1               5                   10      


<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210> 25
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Gly Ala Ser 
1           


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Gln Asn Asp His Ser Tyr Pro Tyr Thr 
1               5                   


<210> 27
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210> 28
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Ile Asn Pro Ser Ser Gly His Ile 
1               5               


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Ala Arg Gly Arg Phe Ala Tyr 
1               5           


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Ser Ser Val Ser Ser Gly Tyr 
1               5           


<210> 31
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Ser Thr Ser 
1           


<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
His Gln Trp Ser Ser Tyr Pro Phe Thr 
1               5                   


<210> 33
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210> 34
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Arg Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ile Ala Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210> 35
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 36
<211> 443
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly His Ile Glu Asn Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210> 37
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu Phe Cys 
1               5                   10                  15      


Phe Ala Ser 
            


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


