                               SEQUENCE LISTING

<110> BIOGEN MA INC.
 
<120> HUMANIZED ANTI-ALPHA V BETA 5 ANTIBODIES AND USES THEREOF

<130> 13751-0221WO1

<140> PCT/US2015/049746
<141> 2015-09-11

<150> 62/049,987
<151> 2014-09-12

<160> 102   

<170> PatentIn version 3.5

<210> 1
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 2
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Glu Val Gln Val Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Phe Thr Ile Ser Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Phe Thr Leu Ser Ala Val Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Glu Val Gln Val Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Phe Thr Ile Ser Ala Asp Thr Ser Pro Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Glu Val Gln Val Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Val Thr Ser Pro Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 7
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 8
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 9
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 10
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 11
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 12
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Ser Tyr Trp Met His 
1               5   


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr 
1               5                   10  


<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
His Gln Tyr Leu Ser Ser Leu Thr 
1               5               


<210> 19
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 20
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210> 21
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr 
            20                  25                  30          


<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210> 23
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 24
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr 
            20                  25                  30          


<210> 25
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Glu Val Gln Val Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 26
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210> 27
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Lys Phe Thr Ile Ser Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr 
            20                  25                  30          


<210> 28
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser 
            20                  25  


<210> 29
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Lys Phe Thr Leu Ser Ala Val Thr Ser Ser Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr 
            20                  25                  30          


<210> 30
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Glu Val Gln Val Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser 
            20                  25  


<210> 31
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Lys Phe Thr Ile Ser Ala Asp Thr Ser Pro Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr 
            20                  25                  30          


<210> 32
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Glu Val Gln Val Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser 
            20                  25  


<210> 33
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Lys Ala Thr Leu Ser Ala Val Thr Ser Pro Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr 
            20                  25                  30          


<210> 34
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 34
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga cagggtgacc       60

atgacctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caaggccccc aagctgctga tctactgggc ctccaccagg      180

gagtccggcg tgcccgacag gttctccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccc tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gccagggcac caagctggag atcaag                                336


<210> 35
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 36
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 38
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210> 39
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210> 40
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys 
            20              


<210> 41
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210> 42
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210> 43
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys 
            20              


<210> 44
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 45
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210> 46
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys 
            20              


<210> 47
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210> 48
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 50
<211> 1048
<212> PRT
<213> Homo sapiens

<400> 50
Met Ala Phe Pro Pro Arg Arg Arg Leu Arg Leu Gly Pro Arg Gly Leu 
1               5                   10                  15      


Pro Leu Leu Leu Ser Gly Leu Leu Leu Pro Leu Cys Arg Ala Phe Asn 
            20                  25                  30          


Leu Asp Val Asp Ser Pro Ala Glu Tyr Ser Gly Pro Glu Gly Ser Tyr 
        35                  40                  45              


Phe Gly Phe Ala Val Asp Phe Phe Val Pro Ser Ala Ser Ser Arg Met 
    50                  55                  60                  


Phe Leu Leu Val Gly Ala Pro Lys Ala Asn Thr Thr Gln Pro Gly Ile 
65                  70                  75                  80  


Val Glu Gly Gly Gln Val Leu Lys Cys Asp Trp Ser Ser Thr Arg Arg 
                85                  90                  95      


Cys Gln Pro Ile Glu Phe Asp Ala Thr Gly Asn Arg Asp Tyr Ala Lys 
            100                 105                 110         


Asp Asp Pro Leu Glu Phe Lys Ser His Gln Trp Phe Gly Ala Ser Val 
        115                 120                 125             


Arg Ser Lys Gln Asp Lys Ile Leu Ala Cys Ala Pro Leu Tyr His Trp 
    130                 135                 140                 


Arg Thr Glu Met Lys Gln Glu Arg Glu Pro Val Gly Thr Cys Phe Leu 
145                 150                 155                 160 


Gln Asp Gly Thr Lys Thr Val Glu Tyr Ala Pro Cys Arg Ser Gln Asp 
                165                 170                 175     


Ile Asp Ala Asp Gly Gln Gly Phe Cys Gln Gly Gly Phe Ser Ile Asp 
            180                 185                 190         


Phe Thr Lys Ala Asp Arg Val Leu Leu Gly Gly Pro Gly Ser Phe Tyr 
        195                 200                 205             


Trp Gln Gly Gln Leu Ile Ser Asp Gln Val Ala Glu Ile Val Ser Lys 
    210                 215                 220                 


Tyr Asp Pro Asn Val Tyr Ser Ile Lys Tyr Asn Asn Gln Leu Ala Thr 
225                 230                 235                 240 


Arg Thr Ala Gln Ala Ile Phe Asp Asp Ser Tyr Leu Gly Tyr Ser Val 
                245                 250                 255     


Ala Val Gly Asp Phe Asn Gly Asp Gly Ile Asp Asp Phe Val Ser Gly 
            260                 265                 270         


Val Pro Arg Ala Ala Arg Thr Leu Gly Met Val Tyr Ile Tyr Asp Gly 
        275                 280                 285             


Lys Asn Met Ser Ser Leu Tyr Asn Phe Thr Gly Glu Gln Met Ala Ala 
    290                 295                 300                 


Tyr Phe Gly Phe Ser Val Ala Ala Thr Asp Ile Asn Gly Asp Asp Tyr 
305                 310                 315                 320 


Ala Asp Val Phe Ile Gly Ala Pro Leu Phe Met Asp Arg Gly Ser Asp 
                325                 330                 335     


Gly Lys Leu Gln Glu Val Gly Gln Val Ser Val Ser Leu Gln Arg Ala 
            340                 345                 350         


Ser Gly Asp Phe Gln Thr Thr Lys Leu Asn Gly Phe Glu Val Phe Ala 
        355                 360                 365             


Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Gln Asp Gly 
    370                 375                 380                 


Phe Asn Asp Ile Ala Ile Ala Ala Pro Tyr Gly Gly Glu Asp Lys Lys 
385                 390                 395                 400 


Gly Ile Val Tyr Ile Phe Asn Gly Arg Ser Thr Gly Leu Asn Ala Val 
                405                 410                 415     


Pro Ser Gln Ile Leu Glu Gly Gln Trp Ala Ala Arg Ser Met Pro Pro 
            420                 425                 430         


Ser Phe Gly Tyr Ser Met Lys Gly Ala Thr Asp Ile Asp Lys Asn Gly 
        435                 440                 445             


Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Val Asp Arg Ala Ile Leu 
    450                 455                 460                 


Tyr Arg Ala Arg Pro Val Ile Thr Val Asn Ala Gly Leu Glu Val Tyr 
465                 470                 475                 480 


Pro Ser Ile Leu Asn Gln Asp Asn Lys Thr Cys Ser Leu Pro Gly Thr 
                485                 490                 495     


Ala Leu Lys Val Ser Cys Phe Asn Val Arg Phe Cys Leu Lys Ala Asp 
            500                 505                 510         


Gly Lys Gly Val Leu Pro Arg Lys Leu Asn Phe Gln Val Glu Leu Leu 
        515                 520                 525             


Leu Asp Lys Leu Lys Gln Lys Gly Ala Ile Arg Arg Ala Leu Phe Leu 
    530                 535                 540                 


Tyr Ser Arg Ser Pro Ser His Ser Lys Asn Met Thr Ile Ser Arg Gly 
545                 550                 555                 560 


Gly Leu Met Gln Cys Glu Glu Leu Ile Ala Tyr Leu Arg Asp Glu Ser 
                565                 570                 575     


Glu Phe Arg Asp Lys Leu Thr Pro Ile Thr Ile Phe Met Glu Tyr Arg 
            580                 585                 590         


Leu Asp Tyr Arg Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro Ile Leu 
        595                 600                 605             


Asn Gln Phe Thr Pro Ala Asn Ile Ser Arg Gln Ala His Ile Leu Leu 
    610                 615                 620                 


Asp Cys Gly Glu Asp Asn Val Cys Lys Pro Lys Leu Glu Val Ser Val 
625                 630                 635                 640 


Asp Ser Asp Gln Lys Lys Ile Tyr Ile Gly Asp Asp Asn Pro Leu Thr 
                645                 650                 655     


Leu Ile Val Lys Ala Gln Asn Gln Gly Glu Gly Ala Tyr Glu Ala Glu 
            660                 665                 670         


Leu Ile Val Ser Ile Pro Leu Gln Ala Asp Phe Ile Gly Val Val Arg 
        675                 680                 685             


Asn Asn Glu Ala Leu Ala Arg Leu Ser Cys Ala Phe Lys Thr Glu Asn 
    690                 695                 700                 


Gln Thr Arg Gln Val Val Cys Asp Leu Gly Asn Pro Met Lys Ala Gly 
705                 710                 715                 720 


Thr Gln Leu Leu Ala Gly Leu Arg Phe Ser Val His Gln Gln Ser Glu 
                725                 730                 735     


Met Asp Thr Ser Val Lys Phe Asp Leu Gln Ile Gln Ser Ser Asn Leu 
            740                 745                 750         


Phe Asp Lys Val Ser Pro Val Val Ser His Lys Val Asp Leu Ala Val 
        755                 760                 765             


Leu Ala Ala Val Glu Ile Arg Gly Val Ser Ser Pro Asp His Val Phe 
    770                 775                 780                 


Leu Pro Ile Pro Asn Trp Glu His Lys Glu Asn Pro Glu Thr Glu Glu 
785                 790                 795                 800 


Asp Val Gly Pro Val Val Gln His Ile Tyr Glu Leu Arg Asn Asn Gly 
                805                 810                 815     


Pro Ser Ser Phe Ser Lys Ala Met Leu His Leu Gln Trp Pro Tyr Lys 
            820                 825                 830         


Tyr Asn Asn Asn Thr Leu Leu Tyr Ile Leu His Tyr Asp Ile Asp Gly 
        835                 840                 845             


Pro Met Asn Cys Thr Ser Asp Met Glu Ile Asn Pro Leu Arg Ile Lys 
    850                 855                 860                 


Ile Ser Ser Leu Gln Thr Thr Glu Lys Asn Asp Thr Val Ala Gly Gln 
865                 870                 875                 880 


Gly Glu Arg Asp His Leu Ile Thr Lys Arg Asp Leu Ala Leu Ser Glu 
                885                 890                 895     


Gly Asp Ile His Thr Leu Gly Cys Gly Val Ala Gln Cys Leu Lys Ile 
            900                 905                 910         


Val Cys Gln Val Gly Arg Leu Asp Arg Gly Lys Ser Ala Ile Leu Tyr 
        915                 920                 925             


Val Lys Ser Leu Leu Trp Thr Glu Thr Phe Met Asn Lys Glu Asn Gln 
    930                 935                 940                 


Asn His Ser Tyr Ser Leu Lys Ser Ser Ala Ser Phe Asn Val Ile Glu 
945                 950                 955                 960 


Phe Pro Tyr Lys Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser Thr Leu 
                965                 970                 975     


Val Thr Thr Asn Val Thr Trp Gly Ile Gln Pro Ala Pro Met Pro Val 
            980                 985                 990         


Pro Val Trp Val Ile Ile Leu Ala  Val Leu Ala Gly Leu  Leu Leu Leu 
        995                 1000                 1005             


Ala Val  Leu Val Phe Val Met  Tyr Arg Met Gly Phe  Phe Lys Arg 
    1010                 1015                 1020             


Val Arg  Pro Pro Gln Glu Glu  Gln Glu Arg Glu Gln  Leu Gln Pro 
    1025                 1030                 1035             


His Glu  Asn Gly Glu Gly Asn  Ser Glu Thr 
    1040                 1045             


<210> 51
<211> 799
<212> PRT
<213> Homo sapiens

<400> 51
Met Pro Arg Ala Pro Ala Pro Leu Tyr Ala Cys Leu Leu Gly Leu Cys 
1               5                   10                  15      


Ala Leu Leu Pro Arg Leu Ala Gly Leu Asn Ile Cys Thr Ser Gly Ser 
            20                  25                  30          


Ala Thr Ser Cys Glu Glu Cys Leu Leu Ile His Pro Lys Cys Ala Trp 
        35                  40                  45              


Cys Ser Lys Glu Asp Phe Gly Ser Pro Arg Ser Ile Thr Ser Arg Cys 
    50                  55                  60                  


Asp Leu Arg Ala Asn Leu Val Lys Asn Gly Cys Gly Gly Glu Ile Glu 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Phe His Val Leu Arg Ser Leu Pro Leu Ser Ser 
                85                  90                  95      


Lys Gly Ser Gly Ser Ala Gly Trp Asp Val Ile Gln Met Thr Pro Gln 
            100                 105                 110         


Glu Ile Ala Val Asn Leu Arg Pro Gly Asp Lys Thr Thr Phe Gln Leu 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Leu Ser Met Lys Asp Asp Leu Asp Asn Ile Arg Ser Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Glu Glu Met Arg Lys Leu Thr Ser Asn Phe Arg 
                165                 170                 175     


Leu Gly Phe Gly Ser Phe Val Asp Lys Asp Ile Ser Pro Phe Ser Tyr 
            180                 185                 190         


Thr Ala Pro Arg Tyr Gln Thr Asn Pro Cys Ile Gly Tyr Lys Leu Phe 
        195                 200                 205             


Pro Asn Cys Val Pro Ser Phe Gly Phe Arg His Leu Leu Pro Leu Thr 
    210                 215                 220                 


Asp Arg Val Asp Ser Phe Asn Glu Glu Val Arg Lys Gln Arg Val Ser 
225                 230                 235                 240 


Arg Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Val Leu Gln Ala 
                245                 250                 255     


Ala Val Cys Lys Glu Lys Ile Gly Trp Arg Lys Asp Ala Leu His Leu 
            260                 265                 270         


Leu Val Phe Thr Thr Asp Asp Val Pro His Ile Ala Leu Asp Gly Lys 
        275                 280                 285             


Leu Gly Gly Leu Val Gln Pro His Asp Gly Gln Cys His Leu Asn Glu 
    290                 295                 300                 


Ala Asn Glu Tyr Thr Ala Ser Asn Gln Met Asp Tyr Pro Ser Leu Ala 
305                 310                 315                 320 


Leu Leu Gly Glu Lys Leu Ala Glu Asn Asn Ile Asn Leu Ile Phe Ala 
                325                 330                 335     


Val Thr Lys Asn His Tyr Met Leu Tyr Lys Asn Phe Thr Ala Leu Ile 
            340                 345                 350         


Pro Gly Thr Thr Val Glu Ile Leu Asp Gly Asp Ser Lys Asn Ile Ile 
        355                 360                 365             


Gln Leu Ile Ile Asn Ala Tyr Asn Ser Ile Arg Ser Lys Val Glu Leu 
    370                 375                 380                 


Ser Val Trp Asp Gln Pro Glu Asp Leu Asn Leu Phe Phe Thr Ala Thr 
385                 390                 395                 400 


Cys Gln Asp Gly Val Ser Tyr Pro Gly Gln Arg Lys Cys Glu Gly Leu 
                405                 410                 415     


Lys Ile Gly Asp Thr Ala Ser Phe Glu Val Ser Leu Glu Ala Arg Ser 
            420                 425                 430         


Cys Pro Ser Arg His Thr Glu His Val Phe Ala Leu Arg Pro Val Gly 
        435                 440                 445             


Phe Arg Asp Ser Leu Glu Val Gly Val Thr Tyr Asn Cys Thr Cys Gly 
    450                 455                 460                 


Cys Ser Val Gly Leu Glu Pro Asn Ser Ala Arg Cys Asn Gly Ser Gly 
465                 470                 475                 480 


Thr Tyr Val Cys Gly Leu Cys Glu Cys Ser Pro Gly Tyr Leu Gly Thr 
                485                 490                 495     


Arg Cys Glu Cys Gln Asp Gly Glu Asn Gln Ser Val Tyr Gln Asn Leu 
            500                 505                 510         


Cys Arg Glu Ala Glu Gly Lys Pro Leu Cys Ser Gly Arg Gly Asp Cys 
        515                 520                 525             


Ser Cys Asn Gln Cys Ser Cys Phe Glu Ser Glu Phe Gly Lys Ile Tyr 
    530                 535                 540                 


Gly Pro Phe Cys Glu Cys Asp Asn Phe Ser Cys Ala Arg Asn Lys Gly 
545                 550                 555                 560 


Val Leu Cys Ser Gly His Gly Glu Cys His Cys Gly Glu Cys Lys Cys 
                565                 570                 575     


His Ala Gly Tyr Ile Gly Asp Asn Cys Asn Cys Ser Thr Asp Ile Ser 
            580                 585                 590         


Thr Cys Arg Gly Arg Asp Gly Gln Ile Cys Ser Glu Arg Gly His Cys 
        595                 600                 605             


Leu Cys Gly Gln Cys Gln Cys Thr Glu Pro Gly Ala Phe Gly Glu Met 
    610                 615                 620                 


Cys Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Ser Thr Lys Arg Asp 
625                 630                 635                 640 


Cys Val Glu Cys Leu Leu Leu His Ser Gly Lys Pro Asp Asn Gln Thr 
                645                 650                 655     


Cys His Ser Leu Cys Arg Asp Glu Val Ile Thr Trp Val Asp Thr Ile 
            660                 665                 670         


Val Lys Asp Asp Gln Glu Ala Val Leu Cys Phe Tyr Lys Thr Ala Lys 
        675                 680                 685             


Asp Cys Val Met Met Phe Thr Tyr Val Glu Leu Pro Ser Gly Lys Ser 
    690                 695                 700                 


Asn Leu Thr Val Leu Arg Glu Pro Glu Cys Gly Asn Thr Pro Asn Ala 
705                 710                 715                 720 


Met Thr Ile Leu Leu Ala Val Val Gly Ser Ile Leu Leu Val Gly Leu 
                725                 730                 735     


Ala Leu Leu Ala Ile Trp Lys Leu Leu Val Thr Ile His Asp Arg Arg 
            740                 745                 750         


Glu Phe Ala Lys Phe Gln Ser Glu Arg Ser Arg Ala Arg Tyr Glu Met 
        755                 760                 765             


Ala Ser Asn Pro Leu Tyr Arg Lys Pro Ile Ser Thr His Thr Val Asp 
    770                 775                 780                 


Phe Thr Phe Asn Lys Phe Asn Lys Ser Tyr Asn Gly Thr Val Asp 
785                 790                 795                 


<210> 52
<211> 799
<212> PRT
<213> Mus musculus

<400> 52
Met Pro Arg Val Pro Ala Thr Leu Tyr Ala Cys Leu Leu Gly Leu Cys 
1               5                   10                  15      


Ala Leu Val Pro Arg Leu Ala Gly Leu Asn Ile Cys Thr Ser Gly Ser 
            20                  25                  30          


Ala Thr Ser Cys Glu Glu Cys Leu Leu Ile His Pro Lys Cys Ala Trp 
        35                  40                  45              


Cys Ser Lys Glu Tyr Phe Gly Asn Pro Arg Ser Ile Thr Ser Arg Cys 
    50                  55                  60                  


Asp Leu Lys Ala Asn Leu Ile Arg Asn Gly Cys Glu Gly Glu Ile Glu 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Thr His Val Leu Arg Asn Leu Pro Leu Ser Ser 
                85                  90                  95      


Lys Gly Ser Ser Ala Thr Gly Ser Asp Val Ile Gln Met Thr Pro Gln 
            100                 105                 110         


Glu Ile Ala Val Ser Leu Arg Pro Gly Glu Gln Thr Thr Phe Gln Leu 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Leu Ser Met Lys Asp Asp Leu Glu Asn Ile Arg Ser Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Glu Glu Met Arg Lys Leu Thr Ser Asn Phe Arg 
                165                 170                 175     


Leu Gly Phe Gly Ser Phe Val Asp Lys Asp Ile Ser Pro Phe Ser Tyr 
            180                 185                 190         


Thr Ala Pro Arg Tyr Gln Thr Asn Pro Cys Ile Gly Tyr Lys Leu Phe 
        195                 200                 205             


Pro Asn Cys Val Pro Ser Phe Gly Phe Arg His Leu Leu Pro Leu Thr 
    210                 215                 220                 


Asp Arg Val Asp Ser Phe Asn Glu Glu Val Arg Lys Gln Arg Val Ser 
225                 230                 235                 240 


Arg Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Val Leu Gln Ala 
                245                 250                 255     


Ala Val Cys Lys Glu Lys Ile Gly Trp Arg Lys Asp Ala Leu His Leu 
            260                 265                 270         


Leu Val Phe Thr Thr Asp Asp Val Pro His Ile Ala Leu Asp Gly Lys 
        275                 280                 285             


Leu Gly Gly Leu Val Gln Pro His Asp Gly Gln Cys His Leu Asn Glu 
    290                 295                 300                 


Ala Asn Glu Tyr Thr Ala Ser Asn Gln Met Asp Tyr Pro Ser Leu Ala 
305                 310                 315                 320 


Leu Leu Gly Glu Lys Leu Ala Glu Asn Asn Ile Asn Leu Ile Phe Ala 
                325                 330                 335     


Val Thr Lys Asn His Tyr Met Leu Tyr Lys Asn Phe Thr Ala Leu Ile 
            340                 345                 350         


Pro Gly Thr Thr Val Glu Ile Leu His Gly Asp Ser Lys Asn Ile Ile 
        355                 360                 365             


Gln Leu Ile Ile Asn Ala Tyr Ser Ser Ile Arg Ala Lys Val Glu Leu 
    370                 375                 380                 


Ser Val Trp Asp Gln Pro Glu Asp Leu Asn Leu Phe Phe Thr Ala Thr 
385                 390                 395                 400 


Cys Gln Asp Gly Ile Ser Tyr Pro Gly Gln Arg Lys Cys Glu Gly Leu 
                405                 410                 415     


Lys Ile Gly Asp Thr Ala Ser Phe Glu Val Ser Val Glu Ala Arg Ser 
            420                 425                 430         


Cys Pro Gly Arg Gln Ala Ala Gln Ser Phe Thr Leu Arg Pro Val Gly 
        435                 440                 445             


Phe Arg Asp Ser Leu Gln Val Glu Val Ala Tyr Asn Cys Thr Cys Gly 
    450                 455                 460                 


Cys Ser Thr Gly Leu Glu Pro Asn Ser Ala Arg Cys Ser Gly Asn Gly 
465                 470                 475                 480 


Thr Tyr Thr Cys Gly Leu Cys Glu Cys Asp Pro Gly Tyr Leu Gly Thr 
                485                 490                 495     


Arg Cys Glu Cys Gln Glu Gly Glu Asn Gln Ser Gly Tyr Gln Asn Leu 
            500                 505                 510         


Cys Arg Glu Ala Glu Gly Lys Pro Leu Cys Ser Gly Arg Gly Glu Cys 
        515                 520                 525             


Ser Cys Asn Gln Cys Ser Cys Phe Glu Ser Glu Phe Gly Arg Ile Tyr 
    530                 535                 540                 


Gly Pro Phe Cys Glu Cys Asp Ser Phe Ser Cys Ala Arg Asn Lys Gly 
545                 550                 555                 560 


Val Leu Cys Ser Gly His Gly Glu Cys His Cys Gly Glu Cys Lys Cys 
                565                 570                 575     


His Ala Gly Tyr Ile Gly Asp Asn Cys Asn Cys Ser Thr Asp Val Ser 
            580                 585                 590         


Thr Cys Arg Ala Lys Asp Gly Gln Ile Cys Ser Asp Arg Gly Arg Cys 
        595                 600                 605             


Val Cys Gly Gln Cys Gln Cys Thr Glu Pro Gly Ala Phe Gly Glu Thr 
    610                 615                 620                 


Cys Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Ser Ser Lys Arg Asp 
625                 630                 635                 640 


Cys Val Glu Cys Leu Leu Leu His Gln Gly Lys Pro Asp Asn Gln Thr 
                645                 650                 655     


Cys His His Gln Cys Lys Asp Glu Val Ile Thr Trp Val Asp Thr Ile 
            660                 665                 670         


Val Lys Asp Asp Gln Glu Ala Val Leu Cys Phe Tyr Lys Thr Ala Lys 
        675                 680                 685             


Asp Cys Val Met Met Phe Ser Tyr Thr Glu Leu Pro Asn Gly Arg Ser 
    690                 695                 700                 


Asn Leu Thr Val Leu Arg Glu Pro Glu Cys Gly Ser Ala Pro Asn Ala 
705                 710                 715                 720 


Met Thr Ile Leu Leu Ala Val Val Gly Ser Ile Leu Leu Ile Gly Met 
                725                 730                 735     


Ala Leu Leu Ala Ile Trp Lys Leu Leu Val Thr Ile His Asp Arg Arg 
            740                 745                 750         


Glu Phe Ala Lys Phe Gln Ser Glu Arg Ser Arg Ala Arg Tyr Glu Met 
        755                 760                 765             


Ala Ser Asn Pro Leu Tyr Arg Lys Pro Ile Ser Thr His Thr Val Asp 
    770                 775                 780                 


Phe Ala Phe Asn Lys Phe Asn Lys Ser Tyr Asn Gly Ser Val Asp 
785                 790                 795                 


<210> 53
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 53
aacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga cagggtgacc       60

atgtcctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caagtccccc aagctgctga tctactgggc ctccaccagg      180

gagtccggcg tgcccgacag gttcaccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccc tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gccagggcac caagctggag atcaag                                336


<210> 54
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 54
gacatccaga tgacccagtc cccctcctcc ctgaccgtgt ccgtgggcga cagggtgacc       60

atgtcctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caagtccccc aagctgctga tctactgggc ctccaccagg      180

gagtccggcg tgcccgacag gttcaccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccg tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gcgccggcac caagctggag atcaag                                336


<210> 55
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 55
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga cagggtgacc       60

atgacctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caaggccccc aagctgctga tctacgccgc ctcctccctg      180

cagtccggcg tgccctccag gttctccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccc tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gccagggcac caagctggag atcaag                                336


<210> 56
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 57
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly 
                325     


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210> 59
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Tyr Pro Gly Asn Ser Asp 
1               5       


<210> 60
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210> 61
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser 
1               5                   10  


<210> 62
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Thr Ser Tyr Trp Met His 
1               5       


<210> 63
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser 
1               5                   10              


<210> 64
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala 
1               5                   10      


<210> 65
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
1               5                   10              


<210> 66
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
1               5                   10  


<210> 67
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
His Gln Tyr Leu Ser Ser Leu 
1               5           


<210> 68
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Gly Gly Gly Ser 
1               


<210> 69
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 69
Glu Val Gln Val Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Phe Thr Ile Ser Ala Asp Thr Ser Pro Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 70
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 70
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 71
<211> 119
<212> PRT
<213> Mus musculus

<400> 71
Glu Val Gln Val Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Pro Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210> 72
<211> 112
<212> PRT
<213> Mus musculus

<400> 72
Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Thr Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 73
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Ser Gly Gly Gly 
1               


<210> 74
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 74
Gly Gly Gly Gly Ser 
1               5   


<210> 75
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 75
Ser Gly Gly Gly Gly 
1               5   


<210> 76
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 76
Gly Gly Gly Gly Gly Ser 
1               5       


<210> 77
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 77
Ser Gly Gly Gly Gly Gly 
1               5       


<210> 78
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 78
Gly Gly Gly Gly Gly Gly Ser 
1               5           


<210> 79
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Ser Gly Gly Gly Gly Gly Gly 
1               5           


<210> 80
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 80
Glu Val Gln Val Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Phe Thr Ile Ser Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 81
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 81
Glu Val Gln Val Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Val Thr Ser Pro Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Thr Thr Tyr Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 82
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 83
<211> 1338
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 83
gaggtgcagc ttgtggagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcgccg cctccggcta caccttcacc tcctactgga tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcag gttcaccatc tccagggacg actccaagaa caccctgtac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagcgcc      360

tccaccaagg gcccatccgt cttccccctg gcgccctgct ccagatctac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc gtgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaagagc agttccagag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaagt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc ccggttga                                                   1338


<210> 84
<211> 1338
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 84
gaggtgcagg tggtggagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcgccg cctccggcta caccttcacc tcctactgga tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcag gttcaccatc tccgccgaca cctccaagaa caccctgtac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagcgcc      360

tccaccaagg gcccatccgt cttccccctg gcgccctgct ccagatctac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc gtgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaagagc agttccagag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaagt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc ccggttga                                                   1338


<210> 85
<211> 1338
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 85
gaggtgcagg tggtgcagtc cggcggcggc ctggtgaagc ccggcgagtc cctgaggctg       60

tcctgcgccg cctccggcta caccttcacc tcctactgga tgcactgggt gaagcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcaa gttcaccatc tccgccgaca cctcctccaa caccgcctac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagcgcc      360

tccaccaagg gcccatccgt cttccccctg gcgccctgct ccagatctac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc gtgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaagagc agttccagag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaagt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc ccggttga                                                   1338


<210> 86
<211> 1338
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 86
gaggtgcagg tggtggagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcaagg cctccggcta caccttcacc tcctactgga tgcactgggt gaagcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcaa gttcaccctg tccgccgtga cctcctccaa caccgcctac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagcgcc      360

tccaccaagg gcccatccgt cttccccctg gcgccctgct ccagatctac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc gtgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaagagc agttccagag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaagt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc ccggttga                                                   1338


<210> 87
<211> 1338
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 87
gaggtgcagg tggtgcagtc cggcggcggc ctggtgaagc ccggcgagtc cctgaggctg       60

tcctgcaagg cctccggcta caccttcacc tcctactgga tgcactgggt gaagcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcaa gttcaccatc tccgccgaca cctcccccaa caccgcctac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagcgcc      360

tccaccaagg gcccatccgt cttccccctg gcgccctgct ccagatctac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc gtgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaagagc agttccagag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaagt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc ccggttga                                                   1338


<210> 88
<211> 1338
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 88
gaggtgcagg tgcagcagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcaagg cctccggcta caccttcacc tcctactgga tgcactgggt gaagcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcaa ggccaccctg tccgccgtga cctcccccaa caccgcctac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagcgcc      360

tccaccaagg gcccatccgt cttccccctg gcgccctgct ccagatctac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc gtgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaagagc agttccagag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaagt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc ccggttga                                                   1338


<210> 89
<211> 1344
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 89
gaggtgcagg tggtggagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcgccg cctccggcta caccttcacc tcctactgga tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggcagg atcaagtcca agaccgacgg cggtaccacc      180

gactacgccg cccccgtgaa gggcaggttc accatctccg ccgacacctc caagaacacc      240

ctgtacctgc agatgaactc cctgaagacc gaggacaccg ccgtgtacta ctgcaccacc      300

accacctacg gctacgactg gttcgcctac tggggccagg gcaccctggt gaccgtctcg      360

agcgcctcca ccaagggccc atccgtcttc cccctggcgc cctgctccag atctacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      660

tccaaatatg gtcccccatg cccaccgtgc ccagcacctg agttcctggg gggaccatca      720

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      780

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      840

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aagagcagtt ccagagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagagcc acaagtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgttggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctcccgg ttga                                            1344


<210> 90
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 90
gacatccaga tgacccagtc cccctcctcc gtgtccgcct ccgtgggcga cagggtgacc       60

atcacctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caaggccccc aagctgctga tctactgggc ctccaccagg      180

gagtccggcg tgccctccag gttctccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccc tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gccagggcac caaggtggag atcaagcgaa ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttga      660


<210> 91
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 91
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga cagggtgacc       60

atgacctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caaggccccc aagctgctga tctactgggc ctccaccagg      180

gagtccggcg tgcccgacag gttctccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccc tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gccagggcac caagctggag atcaagcgaa ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttga      660


<210> 92
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 92
aacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga cagggtgacc       60

atgtcctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caagtccccc aagctgctga tctactgggc ctccaccagg      180

gagtccggcg tgcccgacag gttcaccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccc tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gccagggcac caagctggag atcaagcgaa ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttga      660


<210> 93
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 93
gacatccaga tgacccagtc cccctcctcc ctgaccgtgt ccgtgggcga cagggtgacc       60

atgtcctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caagtccccc aagctgctga tctactgggc ctccaccagg      180

gagtccggcg tgcccgacag gttcaccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccg tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gcgccggcac caagctggag atcaagcgaa ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttga      660


<210> 94
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 94
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga cagggtgacc       60

atgacctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caaggccccc aagctgctga tctacgccgc ctcctccctg      180

cagtccggcg tgccctccag gttctccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccc tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gccagggcac caagctggag atcaagcgaa ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttga      660


<210> 95
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 95
gaggtgcagc ttgtggagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcgccg cctccggcta caccttcacc tcctactgga tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcag gttcaccatc tccagggacg actccaagaa caccctgtac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagc         357


<210> 96
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 96
gaggtgcagg tggtggagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcgccg cctccggcta caccttcacc tcctactgga tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcag gttcaccatc tccgccgaca cctccaagaa caccctgtac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagc         357


<210> 97
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 97
gaggtgcagg tggtgcagtc cggcggcggc ctggtgaagc ccggcgagtc cctgaggctg       60

tcctgcgccg cctccggcta caccttcacc tcctactgga tgcactgggt gaagcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcaa gttcaccatc tccgccgaca cctcctccaa caccgcctac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagc         357


<210> 98
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 98
gaggtgcagg tggtggagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcaagg cctccggcta caccttcacc tcctactgga tgcactgggt gaagcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcaa gttcaccctg tccgccgtga cctcctccaa caccgcctac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagc         357


<210> 99
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 99
gaggtgcagg tggtgcagtc cggcggcggc ctggtgaagc ccggcgagtc cctgaggctg       60

tcctgcaagg cctccggcta caccttcacc tcctactgga tgcactgggt gaagcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcaa gttcaccatc tccgccgaca cctcccccaa caccgcctac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagc         357


<210> 100
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 100
gaggtgcagg tgcagcagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcaagg cctccggcta caccttcacc tcctactgga tgcactgggt gaagcaggcc      120

cccggcaagg gcctggagtg ggtgggcgcc atctaccccg ggaattctga cacctcctac      180

aaccagaagt tcaagggcaa ggccaccctg tccgccgtga cctcccccaa caccgcctac      240

ctgcagatga actccctgaa gaccgaggac accgccgtgt actactgcac caccaccacc      300

tacggctacg actggttcgc ctactggggc cagggcaccc tggtgaccgt ctcgagc         357


<210> 101
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 101
gaggtgcagg tggtggagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg       60

tcctgcgccg cctccggcta caccttcacc tcctactgga tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggcagg atcaagtcca agaccgacgg cggtaccacc      180

gactacgccg cccccgtgaa gggcaggttc accatctccg ccgacacctc caagaacacc      240

ctgtacctgc agatgaactc cctgaagacc gaggacaccg ccgtgtacta ctgcaccacc      300

accacctacg gctacgactg gttcgcctac tggggccagg gcaccctggt gaccgtctcg      360

agc                                                                    363


<210> 102
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 102
gacatccaga tgacccagtc cccctcctcc gtgtccgcct ccgtgggcga cagggtgacc       60

atcacctgca agtcctccca gtccgtgctg tacagctcca accagaagaa ctacctggcc      120

tggtaccagc agaagcccgg caaggccccc aagctgctga tctactgggc ctccaccagg      180

gagtccggcg tgccctccag gttctccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccc tgcagcccga ggacttcgcc acctactact gccaccagta cctctcgagc      300

ctgaccttcg gccagggcac caaggtggag atcaag                                336


