                               SEQUENCE LISTING

<110> WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
 
<120> METHODS OF IDENTIFYING MODULATORS OF SESTRIN-GATOR2 INTERACTION 
      AND USE OF SAME TO MODULATE MTORC1

<130> WIBR-150-WO1

<140> PCT/US2015/049727
<141> 2015-09-11

<150> 62/155,795
<151> 2015-05-01

<150> 62/049,922
<151> 2014-09-12

<160> 31    

<170> PatentIn version 3.5

<210> 1
<211> 551
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Glu Gly Glu Asn Glu Val Arg Trp Asp Gly Leu Cys Ser Arg 
1               5                   10                  15      


Asp Ser Thr Thr Arg Glu Thr Ala Leu Glu Asn Ile Arg Gln Thr Ile 
            20                  25                  30          


Leu Arg Lys Thr Glu Tyr Leu Arg Ser Val Lys Glu Thr Pro His Arg 
        35                  40                  45              


Pro Ser Asp Gly Leu Ser Asn Thr Glu Ser Ser Asp Gly Leu Asn Lys 
    50                  55                  60                  


Leu Leu Ala His Leu Leu Met Leu Ser Lys Arg Cys Pro Phe Lys Asp 
65                  70                  75                  80  


Val Arg Glu Lys Ser Glu Phe Ile Leu Lys Ser Ile Gln Glu Leu Gly 
                85                  90                  95      


Ile Arg Ile Pro Arg Pro Leu Gly Gln Gly Pro Ser Arg Phe Ile Pro 
            100                 105                 110         


Glu Lys Glu Ile Leu Gln Val Gly Ser Glu Asp Ala Gln Met His Ala 
        115                 120                 125             


Leu Phe Ala Asp Ser Phe Ala Ala Leu Gly Arg Leu Asp Asn Ile Thr 
    130                 135                 140                 


Leu Val Met Val Phe His Pro Gln Tyr Leu Glu Ser Phe Leu Lys Thr 
145                 150                 155                 160 


Gln His Tyr Leu Leu Gln Met Asp Gly Pro Leu Pro Leu His Tyr Arg 
                165                 170                 175     


His Tyr Ile Gly Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu 
            180                 185                 190         


Val Asn Leu His Val Asn Asp Phe Leu His Val Gly Gly Asp Pro Lys 
        195                 200                 205             


Trp Leu Asn Gly Leu Glu Asn Ala Pro Gln Lys Leu Gln Asn Leu Gly 
    210                 215                 220                 


Glu Leu Asn Lys Val Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu 
225                 230                 235                 240 


His Ile Glu Gly Leu Leu Lys Ala Glu Glu His Ser Trp Ser Leu Ala 
                245                 250                 255     


Glu Leu Val His Ala Val Val Leu Leu Thr His Tyr His Ser Leu Ala 
            260                 265                 270         


Ser Phe Thr Phe Gly Cys Gly Ile Ser Pro Glu Ile His Cys Asp Gly 
        275                 280                 285             


Gly His Thr Phe Arg Pro Pro Ser Val Ser Asn Tyr Cys Ile Cys Asp 
    290                 295                 300                 


Ile Thr Asn Gly Asn His Ser Val Asp Glu Met Pro Val Asn Ser Ala 
305                 310                 315                 320 


Glu Asn Val Ser Val Ser Asp Ser Phe Phe Glu Val Glu Ala Leu Met 
                325                 330                 335     


Glu Lys Met Arg Gln Leu Gln Glu Cys Arg Asp Glu Glu Glu Ala Ser 
            340                 345                 350         


Gln Glu Glu Met Ala Ser Arg Phe Glu Ile Glu Lys Arg Glu Ser Met 
        355                 360                 365             


Phe Val Phe Ser Ser Asp Asp Glu Glu Val Thr Pro Ala Arg Ala Val 
    370                 375                 380                 


Ser Arg His Phe Glu Asp Thr Ser Tyr Gly Tyr Lys Asp Phe Ser Arg 
385                 390                 395                 400 


His Gly Met His Val Pro Thr Phe Arg Val Gln Asp Tyr Cys Trp Glu 
                405                 410                 415     


Asp His Gly Tyr Ser Leu Val Asn Arg Leu Tyr Pro Asp Val Gly Gln 
            420                 425                 430         


Leu Ile Asp Glu Lys Phe His Ile Ala Tyr Asn Leu Thr Tyr Asn Thr 
        435                 440                 445             


Met Ala Met His Lys Asp Val Asp Thr Ser Met Leu Arg Arg Ala Ile 
    450                 455                 460                 


Trp Asn Tyr Ile His Cys Met Phe Gly Ile Arg Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Tyr Gly Glu Ile Asn Gln Leu Leu Asp Arg Ser Phe Lys Val Tyr Ile 
                485                 490                 495     


Lys Thr Val Val Cys Thr Pro Glu Lys Val Thr Lys Arg Met Tyr Asp 
            500                 505                 510         


Ser Phe Trp Arg Gln Phe Lys His Ser Glu Lys Val His Val Asn Leu 
        515                 520                 525             


Leu Leu Ile Glu Ala Arg Met Gln Ala Glu Leu Leu Tyr Ala Leu Arg 
    530                 535                 540                 


Ala Ile Thr Arg Tyr Met Thr 
545                 550     


<210> 2
<211> 480
<212> PRT
<213> Homo sapiens

<400> 2
Met Ile Val Ala Asp Ser Glu Cys Arg Ala Glu Leu Lys Asp Tyr Leu 
1               5                   10                  15      


Arg Phe Ala Pro Gly Gly Val Gly Asp Ser Gly Pro Gly Glu Glu Gln 
            20                  25                  30          


Arg Glu Ser Arg Ala Arg Arg Gly Pro Arg Gly Pro Ser Ala Phe Ile 
        35                  40                  45              


Pro Val Glu Glu Val Leu Arg Glu Gly Ala Glu Ser Leu Glu Gln His 
    50                  55                  60                  


Leu Gly Leu Glu Ala Leu Met Ser Ser Gly Arg Val Asp Asn Leu Ala 
65                  70                  75                  80  


Val Val Met Gly Leu His Pro Asp Tyr Phe Thr Ser Phe Trp Arg Leu 
                85                  90                  95      


His Tyr Leu Leu Leu His Thr Asp Gly Pro Leu Ala Ser Ser Trp Arg 
            100                 105                 110         


His Tyr Ile Ala Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu 
        115                 120                 125             


Val Gly Ser His Met Ala Glu Phe Leu Gln Thr Gly Gly Asp Pro Glu 
    130                 135                 140                 


Trp Leu Leu Gly Leu His Arg Ala Pro Glu Lys Leu Arg Lys Leu Ser 
145                 150                 155                 160 


Glu Ile Asn Lys Leu Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu 
                165                 170                 175     


His Ile Gln Ala Leu Leu Lys Thr Gly Glu His Thr Trp Ser Leu Ala 
            180                 185                 190         


Glu Leu Ile Gln Ala Leu Val Leu Leu Thr His Cys His Ser Leu Ser 
        195                 200                 205             


Ser Phe Val Phe Gly Cys Gly Ile Leu Pro Glu Gly Asp Ala Asp Gly 
    210                 215                 220                 


Ser Pro Ala Pro Gln Ala Pro Thr Pro Pro Ser Glu Gln Ser Ser Pro 
225                 230                 235                 240 


Pro Ser Arg Asp Pro Leu Asn Asn Ser Gly Gly Phe Glu Ser Ala Arg 
                245                 250                 255     


Asp Val Glu Ala Leu Met Glu Arg Met Gln Gln Leu Gln Glu Ser Leu 
            260                 265                 270         


Leu Arg Asp Glu Gly Thr Ser Gln Glu Glu Met Glu Ser Arg Phe Glu 
        275                 280                 285             


Leu Glu Lys Ser Glu Ser Leu Leu Val Thr Pro Ser Ala Asp Ile Leu 
    290                 295                 300                 


Glu Pro Ser Pro His Pro Asp Met Leu Cys Phe Val Glu Asp Pro Thr 
305                 310                 315                 320 


Phe Gly Tyr Glu Asp Phe Thr Arg Arg Gly Ala Gln Ala Pro Pro Thr 
                325                 330                 335     


Phe Arg Ala Gln Asp Tyr Thr Trp Glu Asp His Gly Tyr Ser Leu Ile 
            340                 345                 350         


Gln Arg Leu Tyr Pro Glu Gly Gly Gln Leu Leu Asp Glu Lys Phe Gln 
        355                 360                 365             


Ala Ala Tyr Ser Leu Thr Tyr Asn Thr Ile Ala Met His Ser Gly Val 
    370                 375                 380                 


Asp Thr Ser Val Leu Arg Arg Ala Ile Trp Asn Tyr Ile His Cys Val 
385                 390                 395                 400 


Phe Gly Ile Arg Tyr Asp Asp Tyr Asp Tyr Gly Glu Val Asn Gln Leu 
                405                 410                 415     


Leu Glu Arg Asn Leu Lys Val Tyr Ile Lys Thr Val Ala Cys Tyr Pro 
            420                 425                 430         


Glu Lys Thr Thr Arg Arg Met Tyr Asn Leu Phe Trp Arg His Phe Arg 
        435                 440                 445             


His Ser Glu Lys Val His Val Asn Leu Leu Leu Leu Glu Ala Arg Met 
    450                 455                 460                 


Gln Ala Ala Leu Leu Tyr Ala Leu Arg Ala Ile Thr Arg Tyr Met Thr 
465                 470                 475                 480 


<210> 3
<211> 492
<212> PRT
<213> Homo sapiens

<400> 3
Met Asn Arg Gly Gly Gly Ser Pro Ser Ala Ala Ala Asn Tyr Leu Leu 
1               5                   10                  15      


Cys Thr Asn Cys Arg Lys Val Leu Arg Lys Asp Lys Arg Ile Arg Val 
            20                  25                  30          


Ser Gln Pro Leu Thr Arg Gly Pro Ser Ala Phe Ile Pro Glu Lys Glu 
        35                  40                  45              


Val Val Gln Ala Asn Thr Val Asp Glu Arg Thr Asn Phe Leu Val Glu 
    50                  55                  60                  


Glu Tyr Ser Thr Ser Gly Arg Leu Asp Asn Ile Thr Gln Val Met Ser 
65                  70                  75                  80  


Leu His Thr Gln Tyr Leu Glu Ser Phe Leu Arg Ser Gln Phe Tyr Met 
                85                  90                  95      


Leu Arg Met Asp Gly Pro Leu Pro Leu Pro Tyr Arg His Tyr Ile Ala 
            100                 105                 110         


Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu Ile Asn Met His 
        115                 120                 125             


Val Asp Glu Phe Leu Lys Thr Gly Gly Ile Ala Glu Trp Leu Asn Gly 
    130                 135                 140                 


Leu Glu Tyr Val Pro Gln Arg Leu Lys Asn Leu Asn Glu Ile Asn Lys 
145                 150                 155                 160 


Leu Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu His Ile Gln Lys 
                165                 170                 175     


Leu Val Lys Thr Gly Glu Asn Asn Trp Ser Leu Pro Glu Leu Val His 
            180                 185                 190         


Ala Val Val Leu Leu Ala His Tyr His Ala Leu Ala Ser Phe Val Phe 
        195                 200                 205             


Gly Ser Gly Ile Asn Pro Glu Arg Asp Pro Glu Ile Ser Asn Gly Phe 
    210                 215                 220                 


Arg Leu Ile Ser Val Asn Asn Phe Cys Val Cys Asp Leu Ala Asn Asp 
225                 230                 235                 240 


Asn Asn Ile Glu Asn Ala Ser Leu Ser Gly Ser Asn Phe Gly Ile Val 
                245                 250                 255     


Asp Ser Leu Ser Glu Leu Glu Ala Leu Met Glu Arg Met Lys Arg Leu 
            260                 265                 270         


Gln Glu Glu Arg Glu Asp Glu Glu Ala Ser Gln Glu Glu Met Ser Thr 
        275                 280                 285             


Arg Phe Glu Lys Glu Lys Lys Glu Ser Leu Phe Val Val Ser Gly Asp 
    290                 295                 300                 


Thr Phe His Ser Phe Pro His Ser Asp Phe Glu Asp Asp Met Ile Ile 
305                 310                 315                 320 


Thr Ser Asp Val Ser Arg Tyr Ile Glu Asp Pro Gly Phe Gly Tyr Glu 
                325                 330                 335     


Asp Phe Ala Arg Arg Gly Glu Glu His Leu Pro Thr Phe Arg Ala Gln 
            340                 345                 350         


Asp Tyr Thr Trp Glu Asn His Gly Phe Ser Leu Val Asn Arg Leu Tyr 
        355                 360                 365             


Ser Asp Ile Gly His Leu Leu Asp Glu Lys Phe Arg Met Val Tyr Asn 
    370                 375                 380                 


Leu Thr Tyr Asn Thr Met Ala Thr His Glu Asp Val Asp Thr Thr Met 
385                 390                 395                 400 


Leu Arg Arg Ala Leu Phe Asn Tyr Val His Cys Met Phe Gly Ile Arg 
                405                 410                 415     


Tyr Asp Asp Tyr Asp Tyr Gly Glu Val Asn Gln Leu Leu Glu Arg Ser 
            420                 425                 430         


Leu Lys Val Tyr Ile Lys Thr Val Thr Cys Tyr Pro Glu Arg Thr Thr 
        435                 440                 445             


Lys Arg Met Tyr Asp Ser Tyr Trp Arg Gln Phe Lys His Ser Glu Lys 
    450                 455                 460                 


Val His Val Asn Leu Leu Leu Met Glu Ala Arg Met Gln Ala Glu Leu 
465                 470                 475                 480 


Leu Tyr Ala Leu Arg Ala Ile Thr Arg His Leu Thr 
                485                 490         


<210> 4
<211> 875
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Gly Thr Lys Pro Asp Ile Leu Trp Ala Pro His His Val Asp 
1               5                   10                  15      


Arg Phe Val Val Cys Asp Ser Glu Leu Ser Leu Tyr His Val Glu Ser 
            20                  25                  30          


Thr Val Asn Ser Glu Leu Lys Ala Gly Ser Leu Arg Leu Ser Glu Asp 
        35                  40                  45              


Ser Ala Ala Thr Leu Leu Ser Ile Asn Ser Asp Thr Pro Tyr Met Lys 
    50                  55                  60                  


Cys Val Ala Trp Tyr Leu Asn Tyr Asp Pro Glu Cys Leu Leu Ala Val 
65                  70                  75                  80  


Gly Gln Ala Asn Gly Arg Val Val Leu Thr Ser Leu Gly Gln Asp His 
                85                  90                  95      


Asn Ser Lys Phe Lys Asp Leu Ile Gly Lys Glu Phe Val Pro Lys His 
            100                 105                 110         


Ala Arg Gln Cys Asn Thr Leu Ala Trp Asn Pro Leu Asp Ser Asn Trp 
        115                 120                 125             


Leu Ala Ala Gly Leu Asp Lys His Arg Ala Asp Phe Ser Val Leu Ile 
    130                 135                 140                 


Trp Asp Ile Cys Ser Lys Tyr Thr Pro Asp Ile Val Pro Met Glu Lys 
145                 150                 155                 160 


Val Lys Leu Ser Ala Gly Glu Thr Glu Thr Thr Leu Leu Val Thr Lys 
                165                 170                 175     


Pro Leu Tyr Glu Leu Gly Gln Asn Asp Ala Cys Leu Ser Leu Cys Trp 
            180                 185                 190         


Leu Pro Arg Asp Gln Lys Leu Leu Leu Ala Gly Met His Arg Asn Leu 
        195                 200                 205             


Ala Ile Phe Asp Leu Arg Asn Thr Ser Gln Lys Met Phe Val Asn Thr 
    210                 215                 220                 


Lys Ala Val Gln Gly Val Thr Val Asp Pro Tyr Phe His Asp Arg Val 
225                 230                 235                 240 


Ala Ser Phe Tyr Glu Gly Gln Val Ala Ile Trp Asp Leu Arg Lys Phe 
                245                 250                 255     


Glu Lys Pro Val Leu Thr Leu Thr Glu Gln Pro Lys Pro Leu Thr Lys 
            260                 265                 270         


Val Ala Trp Cys Pro Thr Arg Thr Gly Leu Leu Ala Thr Leu Thr Arg 
        275                 280                 285             


Asp Ser Asn Ile Ile Arg Leu Tyr Asp Met Gln His Thr Pro Thr Pro 
    290                 295                 300                 


Ile Gly Asp Glu Thr Glu Pro Thr Ile Ile Glu Arg Ser Val Gln Pro 
305                 310                 315                 320 


Cys Asp Asn Tyr Ile Ala Ser Phe Ala Trp His Pro Thr Ser Gln Asn 
                325                 330                 335     


Arg Met Ile Val Val Thr Pro Asn Arg Thr Met Ser Asp Phe Thr Val 
            340                 345                 350         


Phe Glu Arg Ile Ser Leu Ala Trp Ser Pro Ile Thr Ser Leu Met Trp 
        355                 360                 365             


Ala Cys Gly Arg His Leu Tyr Glu Cys Thr Glu Glu Glu Asn Asp Asn 
    370                 375                 380                 


Ser Leu Glu Lys Asp Ile Ala Thr Lys Met Arg Leu Arg Ala Leu Ser 
385                 390                 395                 400 


Arg Tyr Gly Leu Asp Thr Glu Gln Val Trp Arg Asn His Ile Leu Ala 
                405                 410                 415     


Gly Asn Glu Asp Pro Gln Leu Lys Ser Leu Trp Tyr Thr Leu His Phe 
            420                 425                 430         


Met Lys Gln Tyr Thr Glu Asp Met Asp Gln Lys Ser Pro Gly Asn Lys 
        435                 440                 445             


Gly Ser Leu Val Tyr Ala Gly Ile Lys Ser Ile Val Lys Ser Ser Leu 
    450                 455                 460                 


Gly Met Val Glu Ser Ser Arg His Asn Trp Ser Gly Leu Asp Lys Gln 
465                 470                 475                 480 


Ser Asp Ile Gln Asn Leu Asn Glu Glu Arg Ile Leu Ala Leu Gln Leu 
                485                 490                 495     


Cys Gly Trp Ile Lys Lys Gly Thr Asp Val Asp Val Gly Pro Phe Leu 
            500                 505                 510         


Asn Ser Leu Val Gln Glu Gly Glu Trp Glu Arg Ala Ala Ala Val Ala 
        515                 520                 525             


Leu Phe Asn Leu Asp Ile Arg Arg Ala Ile Gln Ile Leu Asn Glu Gly 
    530                 535                 540                 


Ala Ser Ser Glu Lys Gly Asp Leu Asn Leu Asn Val Val Ala Met Ala 
545                 550                 555                 560 


Leu Ser Gly Tyr Thr Asp Glu Lys Asn Ser Leu Trp Arg Glu Met Cys 
                565                 570                 575     


Ser Thr Leu Arg Leu Gln Leu Asn Asn Pro Tyr Leu Cys Val Met Phe 
            580                 585                 590         


Ala Phe Leu Thr Ser Glu Thr Gly Ser Tyr Asp Gly Val Leu Tyr Glu 
        595                 600                 605             


Asn Lys Val Ala Val Arg Asp Arg Val Ala Phe Ala Cys Lys Phe Leu 
    610                 615                 620                 


Ser Asp Thr Gln Leu Asn Arg Tyr Ile Glu Lys Leu Thr Asn Glu Met 
625                 630                 635                 640 


Lys Glu Ala Gly Asn Leu Glu Gly Ile Leu Leu Thr Gly Leu Thr Lys 
                645                 650                 655     


Asp Gly Val Asp Leu Met Glu Ser Tyr Val Asp Arg Thr Gly Asp Val 
            660                 665                 670         


Gln Thr Ala Ser Tyr Cys Met Leu Gln Gly Ser Pro Leu Asp Val Leu 
        675                 680                 685             


Lys Asp Glu Arg Val Gln Tyr Trp Ile Glu Asn Tyr Arg Asn Leu Leu 
    690                 695                 700                 


Asp Ala Trp Arg Phe Trp His Lys Arg Ala Glu Phe Asp Ile His Arg 
705                 710                 715                 720 


Ser Lys Leu Asp Pro Ser Ser Lys Pro Leu Ala Gln Val Phe Val Ser 
                725                 730                 735     


Cys Asn Phe Cys Gly Lys Ser Ile Ser Tyr Ser Cys Ser Ala Val Pro 
            740                 745                 750         


His Gln Gly Arg Gly Phe Ser Gln Tyr Gly Val Ser Gly Ser Pro Thr 
        755                 760                 765             


Lys Ser Lys Val Thr Ser Cys Pro Gly Cys Arg Lys Pro Leu Pro Arg 
    770                 775                 780                 


Cys Ala Leu Cys Leu Ile Asn Met Gly Thr Pro Val Ser Ser Cys Pro 
785                 790                 795                 800 


Gly Gly Thr Lys Ser Asp Glu Lys Val Asp Leu Ser Lys Asp Lys Lys 
                805                 810                 815     


Leu Ala Gln Phe Asn Asn Trp Phe Thr Trp Cys His Asn Cys Arg His 
            820                 825                 830         


Gly Gly His Ala Gly His Met Leu Ser Trp Phe Arg Asp His Ala Glu 
        835                 840                 845             


Cys Pro Val Ser Ala Cys Thr Cys Lys Cys Met Gln Leu Asp Thr Thr 
    850                 855                 860                 


Gly Asn Leu Val Pro Ala Glu Thr Val Gln Pro 
865                 870                 875 


<210> 5
<211> 322
<212> PRT
<213> Homo sapiens

<400> 5
Met Val Ser Val Ile Asn Thr Val Asp Thr Ser His Glu Asp Met Ile 
1               5                   10                  15      


His Asp Ala Gln Met Asp Tyr Tyr Gly Thr Arg Leu Ala Thr Cys Ser 
            20                  25                  30          


Ser Asp Arg Ser Val Lys Ile Phe Asp Val Arg Asn Gly Gly Gln Ile 
        35                  40                  45              


Leu Ile Ala Asp Leu Arg Gly His Glu Gly Pro Val Trp Gln Val Ala 
    50                  55                  60                  


Trp Ala His Pro Met Tyr Gly Asn Ile Leu Ala Ser Cys Ser Tyr Asp 
65                  70                  75                  80  


Arg Lys Val Ile Ile Trp Arg Glu Glu Asn Gly Thr Trp Glu Lys Ser 
                85                  90                  95      


His Glu His Ala Gly His Asp Ser Ser Val Asn Ser Val Cys Trp Ala 
            100                 105                 110         


Pro His Asp Tyr Gly Leu Ile Leu Ala Cys Gly Ser Ser Asp Gly Ala 
        115                 120                 125             


Ile Ser Leu Leu Thr Tyr Thr Gly Glu Gly Gln Trp Glu Val Lys Lys 
    130                 135                 140                 


Ile Asn Asn Ala His Thr Ile Gly Cys Asn Ala Val Ser Trp Ala Pro 
145                 150                 155                 160 


Ala Val Val Pro Gly Ser Leu Ile Asp His Pro Ser Gly Gln Lys Pro 
                165                 170                 175     


Asn Tyr Ile Lys Arg Phe Ala Ser Gly Gly Cys Asp Asn Leu Ile Lys 
            180                 185                 190         


Leu Trp Lys Glu Glu Glu Asp Gly Gln Trp Lys Glu Glu Gln Lys Leu 
        195                 200                 205             


Glu Ala His Ser Asp Trp Val Arg Asp Val Ala Trp Ala Pro Ser Ile 
    210                 215                 220                 


Gly Leu Pro Thr Ser Thr Ile Ala Ser Cys Ser Gln Asp Gly Arg Val 
225                 230                 235                 240 


Phe Ile Trp Thr Cys Asp Asp Ala Ser Ser Asn Thr Trp Ser Pro Lys 
                245                 250                 255     


Leu Leu His Lys Phe Asn Asp Val Val Trp His Val Ser Trp Ser Ile 
            260                 265                 270         


Thr Ala Asn Ile Leu Ala Val Ser Gly Gly Asp Asn Lys Val Thr Leu 
        275                 280                 285             


Trp Lys Glu Ser Val Asp Gly Gln Trp Val Cys Ile Ser Asp Val Asn 
    290                 295                 300                 


Lys Gly Gln Gly Ser Val Ser Ala Ser Val Thr Glu Gly Gln Gln Asn 
305                 310                 315                 320 


Glu Gln 
        


<210> 6
<211> 920
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Lys Lys Arg Thr Thr Ser Gly Glu Gly Arg Glu Arg Gln Arg 
1               5                   10                  15      


Leu Pro Ala Arg Arg Phe Arg Thr Thr Ser Pro Ala Ala Leu Arg Ala 
            20                  25                  30          


Asp Ser Val Asp Gly Gly Ser Leu Leu Ala Pro Leu Leu Gly Leu Thr 
        35                  40                  45              


Asp Arg Ala Phe Ser Asp Cys Pro Asp Leu Ala Asp Gly Ala Met Glu 
    50                  55                  60                  


Lys Met Ser Arg Val Thr Thr Ala Leu Gly Gly Ser Val Leu Thr Gly 
65                  70                  75                  80  


Arg Thr Met His Cys His Leu Asp Ala Pro Ala Asn Ala Ile Ser Val 
                85                  90                  95      


Cys Arg Asp Ala Ala Gln Val Val Val Ala Gly Arg Ser Ile Phe Lys 
            100                 105                 110         


Ile Tyr Ala Ile Glu Glu Glu Gln Phe Val Glu Lys Leu Asn Leu Arg 
        115                 120                 125             


Val Gly Arg Lys Pro Ser Leu Asn Leu Ser Cys Ala Asp Val Val Trp 
    130                 135                 140                 


His Gln Met Asp Glu Asn Leu Leu Ala Thr Ala Ala Thr Asn Gly Val 
145                 150                 155                 160 


Val Val Thr Trp Asn Leu Gly Arg Pro Ser Arg Asn Lys Gln Asp Gln 
                165                 170                 175     


Leu Phe Thr Glu His Lys Arg Thr Val Asn Lys Val Cys Phe His Pro 
            180                 185                 190         


Thr Glu Ala His Val Leu Leu Ser Gly Ser Gln Asp Gly Phe Met Lys 
        195                 200                 205             


Cys Phe Asp Leu Arg Arg Lys Asp Ser Val Ser Thr Phe Ser Gly Glu 
    210                 215                 220                 


Ala Thr Glu Ala Gly Pro Arg Glu Trp Ala Met Ala Gly Cys Val Pro 
225                 230                 235                 240 


Ile Leu Pro Val Leu Ser Cys Arg Ile Leu Arg Leu His His Ser Phe 
                245                 250                 255     


Ala His Gly Pro Met Gln Asp Ala Glu Ser Thr Ala Asn Asp Ala Arg 
            260                 265                 270         


Glu Ser Trp Gly Cys Pro Leu Tyr Pro Leu Gly Leu Cys Ser Gly Pro 
        275                 280                 285             


Gln Ala Gly Gln Ser Glu Ser Val Arg Asp Val Gln Phe Ser Ile Arg 
    290                 295                 300                 


Asp Tyr Phe Thr Phe Ala Ser Thr Phe Glu Asn Gly Asn Val Gln Leu 
305                 310                 315                 320 


Trp Asp Ile Arg Arg Pro Asp Arg Cys Glu Arg Met Phe Thr Ala His 
                325                 330                 335     


Asn Gly Pro Val Phe Cys Cys Asp Trp His Pro Glu Asp Arg Gly Trp 
            340                 345                 350         


Leu Ala Thr Gly Gly Arg Asp Lys Met Val Lys Val Trp Asp Met Thr 
        355                 360                 365             


Thr His Arg Ala Lys Glu Met His Cys Val Gln Thr Ile Ala Ser Val 
    370                 375                 380                 


Ala Arg Val Lys Trp Arg Pro Glu Cys Arg His His Leu Ala Thr Cys 
385                 390                 395                 400 


Ser Met Met Val Asp His Asn Ile Tyr Val Trp Asp Val Arg Arg Pro 
                405                 410                 415     


Phe Val Pro Ala Ala Met Phe Glu Glu His Arg Asp Val Thr Thr Gly 
            420                 425                 430         


Ile Ala Trp Arg His Pro His Asp Pro Ser Phe Leu Leu Ser Gly Ser 
        435                 440                 445             


Lys Asp Ser Ser Leu Cys Gln His Leu Phe Arg Asp Ala Ser Gln Pro 
    450                 455                 460                 


Val Glu Arg Ala Asn Pro Glu Gly Leu Cys Tyr Gly Leu Phe Gly Asp 
465                 470                 475                 480 


Leu Ala Phe Ala Ala Lys Glu Ser Leu Val Ala Ala Glu Ser Gly Arg 
                485                 490                 495     


Lys Pro Tyr Thr Gly Asp Arg Arg His Pro Ile Phe Phe Lys Arg Lys 
            500                 505                 510         


Leu Asp Pro Ala Glu Pro Phe Ala Gly Leu Ala Ser Ser Ala Leu Ser 
        515                 520                 525             


Val Phe Glu Thr Glu Pro Gly Gly Gly Gly Met Arg Trp Phe Val Asp 
    530                 535                 540                 


Thr Ala Glu Arg Tyr Ala Leu Ala Gly Arg Pro Leu Ala Glu Leu Cys 
545                 550                 555                 560 


Asp His Asn Ala Lys Val Ala Arg Glu Leu Gly Arg Asn Gln Val Ala 
                565                 570                 575     


Gln Thr Trp Thr Met Leu Arg Ile Ile Tyr Cys Ser Pro Gly Leu Val 
            580                 585                 590         


Pro Thr Ala Asn Leu Asn His Ser Val Gly Lys Gly Gly Ser Cys Gly 
        595                 600                 605             


Leu Pro Leu Met Asn Ser Phe Asn Leu Lys Asp Met Ala Pro Gly Leu 
    610                 615                 620                 


Gly Ser Glu Thr Arg Leu Asp Arg Ser Lys Gly Asp Ala Arg Ser Asp 
625                 630                 635                 640 


Thr Val Leu Leu Asp Ser Ser Ala Thr Leu Ile Thr Asn Glu Asp Asn 
                645                 650                 655     


Glu Glu Thr Glu Gly Ser Asp Val Pro Ala Asp Tyr Leu Leu Gly Asp 
            660                 665                 670         


Val Glu Gly Glu Glu Asp Glu Leu Tyr Leu Leu Asp Pro Glu His Ala 
        675                 680                 685             


His Pro Glu Asp Pro Glu Cys Val Leu Pro Gln Glu Ala Phe Pro Leu 
    690                 695                 700                 


Arg His Glu Ile Val Asp Thr Pro Pro Gly Pro Glu His Leu Gln Asp 
705                 710                 715                 720 


Lys Ala Asp Ser Pro His Val Ser Gly Ser Glu Ala Asp Val Ala Ser 
                725                 730                 735     


Leu Ala Pro Val Asp Ser Ser Phe Ser Leu Leu Ser Val Ser His Ala 
            740                 745                 750         


Leu Tyr Asp Ser Arg Leu Pro Pro Asp Phe Phe Gly Val Leu Val Arg 
        755                 760                 765             


Asp Met Leu His Phe Tyr Ala Glu Gln Gly Asp Val Gln Met Ala Val 
    770                 775                 780                 


Ser Val Leu Ile Val Leu Gly Glu Arg Val Arg Lys Asp Ile Asp Glu 
785                 790                 795                 800 


Gln Thr Gln Glu His Trp Tyr Thr Ser Tyr Ile Asp Leu Leu Gln Arg 
                805                 810                 815     


Phe Arg Leu Trp Asn Val Ser Asn Glu Val Val Lys Leu Ser Thr Ser 
            820                 825                 830         


Arg Ala Val Ser Cys Leu Asn Gln Ala Ser Thr Thr Leu His Val Asn 
        835                 840                 845             


Cys Ser His Cys Lys Arg Pro Met Ser Ser Arg Gly Trp Val Cys Asp 
    850                 855                 860                 


Arg Cys His Arg Cys Ala Ser Met Cys Ala Val Cys His His Val Val 
865                 870                 875                 880 


Lys Gly Leu Phe Val Trp Cys Gln Gly Cys Ser His Gly Gly His Leu 
                885                 890                 895     


Gln His Ile Met Lys Trp Leu Glu Gly Ser Ser His Cys Pro Ala Gly 
            900                 905                 910         


Cys Gly His Leu Cys Glu Tyr Ser 
        915                 920 


<210> 7
<211> 974
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Ala Arg Trp Ser Ser Glu Asn Val Val Val Glu Phe Arg Asp 
1               5                   10                  15      


Ser Gln Ala Thr Ala Met Ser Val Asp Cys Leu Gly Gln His Ala Val 
            20                  25                  30          


Leu Ser Gly Arg Arg Phe Leu Tyr Ile Val Asn Leu Asp Ala Pro Phe 
        35                  40                  45              


Glu Gly His Arg Lys Ile Ser Arg Gln Ser Lys Trp Asp Ile Gly Ala 
    50                  55                  60                  


Val Gln Trp Asn Pro His Asp Ser Phe Ala His Tyr Phe Ala Ala Ser 
65                  70                  75                  80  


Ser Asn Gln Arg Val Asp Leu Tyr Lys Trp Lys Asp Gly Ser Gly Glu 
                85                  90                  95      


Val Gly Thr Thr Leu Gln Gly His Thr Arg Val Ile Ser Asp Leu Asp 
            100                 105                 110         


Trp Ala Val Phe Glu Pro Asp Leu Leu Val Thr Ser Ser Val Asp Thr 
        115                 120                 125             


Tyr Ile Tyr Ile Trp Asp Ile Lys Asp Thr Arg Lys Pro Thr Val Ala 
    130                 135                 140                 


Leu Ser Ala Val Ala Gly Ala Ser Gln Val Lys Trp Asn Lys Lys Asn 
145                 150                 155                 160 


Ala Asn Cys Leu Ala Thr Ser His Asp Gly Asp Val Arg Ile Trp Asp 
                165                 170                 175     


Lys Arg Lys Pro Ser Thr Ala Val Glu Tyr Leu Ala Ala His Leu Ser 
            180                 185                 190         


Lys Ile His Gly Leu Asp Trp His Pro Asp Ser Glu His Ile Leu Ala 
        195                 200                 205             


Thr Ser Ser Gln Asp Asn Ser Val Lys Phe Trp Asp Tyr Arg Gln Pro 
    210                 215                 220                 


Arg Lys Tyr Leu Asn Ile Leu Pro Cys Gln Val Pro Val Trp Lys Ala 
225                 230                 235                 240 


Arg Tyr Thr Pro Phe Ser Asn Gly Leu Val Thr Val Met Val Pro Gln 
                245                 250                 255     


Leu Arg Arg Glu Asn Ser Leu Leu Leu Trp Asn Val Phe Asp Leu Asn 
            260                 265                 270         


Thr Pro Val His Thr Phe Val Gly His Asp Asp Val Val Leu Glu Phe 
        275                 280                 285             


Gln Trp Arg Lys Gln Lys Glu Gly Ser Lys Asp Tyr Gln Leu Val Thr 
    290                 295                 300                 


Trp Ser Arg Asp Gln Thr Leu Arg Met Trp Arg Val Asp Ser Gln Met 
305                 310                 315                 320 


Gln Arg Leu Cys Ala Asn Asp Ile Leu Asp Gly Val Asp Glu Phe Ile 
                325                 330                 335     


Glu Ser Ile Ser Leu Leu Pro Glu Pro Glu Lys Thr Leu His Thr Glu 
            340                 345                 350         


Asp Thr Asp His Gln His Thr Ala Ser His Gly Glu Glu Glu Ala Leu 
        355                 360                 365             


Lys Glu Asp Pro Pro Arg Asn Leu Leu Glu Glu Arg Lys Ser Asp Gln 
    370                 375                 380                 


Leu Gly Leu Pro Gln Thr Leu Gln Gln Glu Phe Ser Leu Ile Asn Val 
385                 390                 395                 400 


Gln Ile Arg Asn Val Asn Val Glu Met Asp Ala Ala Asp Arg Ser Cys 
                405                 410                 415     


Thr Val Ser Val His Cys Ser Asn His Arg Val Lys Met Leu Val Lys 
            420                 425                 430         


Phe Pro Ala Gln Tyr Pro Asn Asn Ala Ala Pro Ser Phe Gln Phe Ile 
        435                 440                 445             


Asn Pro Thr Thr Ile Thr Ser Thr Met Lys Ala Lys Leu Leu Lys Ile 
    450                 455                 460                 


Leu Lys Asp Thr Ala Leu Gln Lys Val Lys Arg Gly Gln Ser Cys Leu 
465                 470                 475                 480 


Glu Pro Cys Leu Arg Gln Leu Val Ser Cys Leu Glu Ser Phe Val Asn 
                485                 490                 495     


Gln Glu Asp Ser Ala Ser Ser Asn Pro Phe Ala Leu Pro Asn Ser Val 
            500                 505                 510         


Thr Pro Pro Leu Pro Thr Phe Ala Arg Val Thr Thr Ala Tyr Gly Ser 
        515                 520                 525             


Tyr Gln Asp Ala Asn Ile Pro Phe Pro Arg Thr Ser Gly Ala Arg Phe 
    530                 535                 540                 


Cys Gly Ala Gly Tyr Leu Val Tyr Phe Thr Arg Pro Met Thr Met His 
545                 550                 555                 560 


Arg Ala Val Ser Pro Thr Glu Pro Thr Pro Arg Ser Leu Ser Ala Leu 
                565                 570                 575     


Ser Ala Tyr His Thr Gly Leu Ile Ala Pro Met Lys Ile Arg Thr Glu 
            580                 585                 590         


Ala Pro Gly Asn Leu Arg Leu Tyr Ser Gly Ser Pro Thr Arg Ser Glu 
        595                 600                 605             


Lys Glu Gln Val Ser Ile Ser Ser Phe Tyr Tyr Lys Glu Arg Lys Ser 
    610                 615                 620                 


Arg Arg Trp Lys Ser Lys Arg Glu Gly Ser Asp Ser Gly Asn Arg Gln 
625                 630                 635                 640 


Ile Lys Ala Ala Gly Lys Val Ile Ile Gln Asp Ile Ala Cys Leu Leu 
                645                 650                 655     


Pro Val His Lys Ser Leu Gly Glu Leu Tyr Ile Leu Asn Val Asn Asp 
            660                 665                 670         


Ile Gln Glu Thr Cys Gln Lys Asn Ala Ala Ser Ala Leu Leu Val Gly 
        675                 680                 685             


Arg Lys Asp Leu Val Gln Val Trp Ser Leu Ala Thr Val Ala Thr Asp 
    690                 695                 700                 


Leu Cys Leu Gly Pro Lys Ser Asp Pro Asp Leu Glu Thr Pro Trp Ala 
705                 710                 715                 720 


Arg His Pro Phe Gly Arg Gln Leu Leu Glu Ser Leu Leu Ala His Tyr 
                725                 730                 735     


Cys Arg Leu Arg Asp Val Gln Thr Leu Ala Met Leu Cys Ser Val Phe 
            740                 745                 750         


Glu Ala Gln Ser Arg Pro Gln Gly Leu Pro Asn Pro Phe Gly Pro Phe 
        755                 760                 765             


Pro Asn Arg Ser Ser Asn Leu Val Val Ser His Ser Arg Tyr Pro Ser 
    770                 775                 780                 


Phe Thr Ser Ser Gly Ser Cys Ser Ser Met Ser Asp Pro Gly Leu Asn 
785                 790                 795                 800 


Thr Gly Gly Trp Asn Ile Ala Gly Arg Glu Ala Glu His Leu Ser Ser 
                805                 810                 815     


Pro Trp Gly Glu Ser Ser Pro Glu Glu Leu Arg Phe Gly Ser Leu Thr 
            820                 825                 830         


Tyr Ser Asp Pro Arg Glu Arg Glu Arg Asp Gln His Asp Lys Asn Lys 
        835                 840                 845             


Arg Leu Leu Asp Pro Ala Asn Thr Gln Gln Phe Asp Asp Phe Lys Lys 
    850                 855                 860                 


Cys Tyr Gly Glu Ile Leu Tyr Arg Trp Gly Leu Arg Glu Lys Arg Ala 
865                 870                 875                 880 


Glu Val Leu Lys Phe Val Ser Cys Pro Pro Asp Pro His Lys Gly Ile 
                885                 890                 895     


Glu Phe Gly Val Tyr Cys Ser His Cys Arg Ser Glu Val Arg Gly Thr 
            900                 905                 910         


Gln Cys Ala Ile Cys Lys Gly Phe Thr Phe Gln Cys Ala Ile Cys His 
        915                 920                 925             


Val Ala Val Arg Gly Ser Ser Asn Phe Cys Leu Thr Cys Gly His Gly 
    930                 935                 940                 


Gly His Thr Ser His Met Met Glu Trp Phe Arg Thr Gln Glu Val Cys 
945                 950                 955                 960 


Pro Thr Gly Cys Gly Cys His Cys Leu Leu Glu Ser Thr Phe 
                965                 970                 


<210> 8
<211> 360
<212> PRT
<213> Homo sapiens

<400> 8
Met Phe Val Ala Arg Ser Ile Ala Ala Asp His Lys Asp Leu Ile His 
1               5                   10                  15      


Asp Val Ser Phe Asp Phe His Gly Arg Arg Met Ala Thr Cys Ser Ser 
            20                  25                  30          


Asp Gln Ser Val Lys Val Trp Asp Lys Ser Glu Ser Gly Asp Trp His 
        35                  40                  45              


Cys Thr Ala Ser Trp Lys Thr His Ser Gly Ser Val Trp Arg Val Thr 
    50                  55                  60                  


Trp Ala His Pro Glu Phe Gly Gln Val Leu Ala Ser Cys Ser Phe Asp 
65                  70                  75                  80  


Arg Thr Ala Ala Val Trp Glu Glu Ile Val Gly Glu Ser Asn Asp Lys 
                85                  90                  95      


Leu Arg Gly Gln Ser His Trp Val Lys Arg Thr Thr Leu Val Asp Ser 
            100                 105                 110         


Arg Thr Ser Val Thr Asp Val Lys Phe Ala Pro Lys His Met Gly Leu 
        115                 120                 125             


Met Leu Ala Thr Cys Ser Ala Asp Gly Ile Val Arg Ile Tyr Glu Ala 
    130                 135                 140                 


Pro Asp Val Met Asn Leu Ser Gln Trp Ser Leu Gln His Glu Ile Ser 
145                 150                 155                 160 


Cys Lys Leu Ser Cys Ser Cys Ile Ser Trp Asn Pro Ser Ser Ser Arg 
                165                 170                 175     


Ala His Ser Pro Met Ile Ala Val Gly Ser Asp Asp Ser Ser Pro Asn 
            180                 185                 190         


Ala Met Ala Lys Val Gln Ile Phe Glu Tyr Asn Glu Asn Thr Arg Lys 
        195                 200                 205             


Tyr Ala Lys Ala Glu Thr Leu Met Thr Val Thr Asp Pro Val His Asp 
    210                 215                 220                 


Ile Ala Phe Ala Pro Asn Leu Gly Arg Ser Phe His Ile Leu Ala Ile 
225                 230                 235                 240 


Ala Thr Lys Asp Val Arg Ile Phe Thr Leu Lys Pro Val Arg Lys Glu 
                245                 250                 255     


Leu Thr Ser Ser Gly Gly Pro Thr Lys Phe Glu Ile His Ile Val Ala 
            260                 265                 270         


Gln Phe Asp Asn His Asn Ser Gln Val Trp Arg Val Ser Trp Asn Ile 
        275                 280                 285             


Thr Gly Thr Val Leu Ala Ser Ser Gly Asp Asp Gly Cys Val Arg Leu 
    290                 295                 300                 


Trp Lys Ala Asn Tyr Met Asp Asn Trp Lys Cys Thr Gly Ile Leu Lys 
305                 310                 315                 320 


Gly Asn Gly Ser Pro Val Asn Gly Ser Ser Gln Gln Gly Thr Ser Asn 
                325                 330                 335     


Pro Ser Leu Gly Ser Thr Ile Pro Ser Leu Gln Asn Ser Leu Asn Gly 
            340                 345                 350         


Ser Ser Ala Gly Arg Lys His Ser 
        355                 360 


<210> 9
<211> 492
<212> PRT
<213> Homo sapiens

<400> 9
Met Arg Leu Ala Ala Ala Ala Asn Glu Ala Tyr Thr Ala Pro Leu Ala 
1               5                   10                  15      


Val Ser Gly Leu Leu Gly Cys Lys Gln Cys Gly Gly Gly Arg Asp Gln 
            20                  25                  30          


Asp Glu Glu Leu Gly Ile Arg Ile Pro Arg Pro Leu Gly Gln Gly Pro 
        35                  40                  45              


Ser Arg Phe Ile Pro Glu Lys Glu Ile Leu Gln Val Gly Ser Glu Asp 
    50                  55                  60                  


Ala Gln Met His Ala Leu Phe Ala Asp Ser Phe Ala Ala Leu Gly Arg 
65                  70                  75                  80  


Leu Asp Asn Ile Thr Leu Val Met Val Phe His Pro Gln Tyr Leu Glu 
                85                  90                  95      


Ser Phe Leu Lys Thr Gln His Tyr Leu Leu Gln Met Asp Gly Pro Leu 
            100                 105                 110         


Pro Leu His Tyr Arg His Tyr Ile Gly Ile Met Ala Ala Ala Arg His 
        115                 120                 125             


Gln Cys Ser Tyr Leu Val Asn Leu His Val Asn Asp Phe Leu His Val 
    130                 135                 140                 


Gly Gly Asp Pro Lys Trp Leu Asn Gly Leu Glu Asn Ala Pro Gln Lys 
145                 150                 155                 160 


Leu Gln Asn Leu Gly Glu Leu Asn Lys Val Leu Ala His Arg Pro Trp 
                165                 170                 175     


Leu Ile Thr Lys Glu His Ile Glu Gly Leu Leu Lys Ala Glu Glu His 
            180                 185                 190         


Ser Trp Ser Leu Ala Glu Leu Val His Ala Val Val Leu Leu Thr His 
        195                 200                 205             


Tyr His Ser Leu Ala Ser Phe Thr Phe Gly Cys Gly Ile Ser Pro Glu 
    210                 215                 220                 


Ile His Cys Asp Gly Gly His Thr Phe Arg Pro Pro Ser Val Ser Asn 
225                 230                 235                 240 


Tyr Cys Ile Cys Asp Ile Thr Asn Gly Asn His Ser Val Asp Glu Met 
                245                 250                 255     


Pro Val Asn Ser Ala Glu Asn Val Ser Val Ser Asp Ser Phe Phe Glu 
            260                 265                 270         


Val Glu Ala Leu Met Glu Lys Met Arg Gln Leu Gln Glu Cys Arg Asp 
        275                 280                 285             


Glu Glu Glu Ala Ser Gln Glu Glu Met Ala Ser Arg Phe Glu Ile Glu 
    290                 295                 300                 


Lys Arg Glu Ser Met Phe Val Phe Ser Ser Asp Asp Glu Glu Val Thr 
305                 310                 315                 320 


Pro Ala Arg Ala Val Ser Arg His Phe Glu Asp Thr Ser Tyr Gly Tyr 
                325                 330                 335     


Lys Asp Phe Ser Arg His Gly Met His Val Pro Thr Phe Arg Val Gln 
            340                 345                 350         


Asp Tyr Cys Trp Glu Asp His Gly Tyr Ser Leu Val Asn Arg Leu Tyr 
        355                 360                 365             


Pro Asp Val Gly Gln Leu Ile Asp Glu Lys Phe His Ile Ala Tyr Asn 
    370                 375                 380                 


Leu Thr Tyr Asn Thr Met Ala Met His Lys Asp Val Asp Thr Ser Met 
385                 390                 395                 400 


Leu Arg Arg Ala Ile Trp Asn Tyr Ile His Cys Met Phe Gly Ile Arg 
                405                 410                 415     


Tyr Asp Asp Tyr Asp Tyr Gly Glu Ile Asn Gln Leu Leu Asp Arg Ser 
            420                 425                 430         


Phe Lys Val Tyr Ile Lys Thr Val Val Cys Thr Pro Glu Lys Val Thr 
        435                 440                 445             


Lys Arg Met Tyr Asp Ser Phe Trp Arg Gln Phe Lys His Ser Glu Lys 
    450                 455                 460                 


Val His Val Asn Leu Leu Leu Ile Glu Ala Arg Met Gln Ala Glu Leu 
465                 470                 475                 480 


Leu Tyr Ala Leu Arg Ala Ile Thr Arg Tyr Met Thr 
                485                 490         


<210> 10
<211> 426
<212> PRT
<213> Homo sapiens

<400> 10
Met His Ala Leu Phe Ala Asp Ser Phe Ala Ala Leu Gly Arg Leu Asp 
1               5                   10                  15      


Asn Ile Thr Leu Val Met Val Phe His Pro Gln Tyr Leu Glu Ser Phe 
            20                  25                  30          


Leu Lys Thr Gln His Tyr Leu Leu Gln Met Asp Gly Pro Leu Pro Leu 
        35                  40                  45              


His Tyr Arg His Tyr Ile Gly Ile Met Ala Ala Ala Arg His Gln Cys 
    50                  55                  60                  


Ser Tyr Leu Val Asn Leu His Val Asn Asp Phe Leu His Val Gly Gly 
65                  70                  75                  80  


Asp Pro Lys Trp Leu Asn Gly Leu Glu Asn Ala Pro Gln Lys Leu Gln 
                85                  90                  95      


Asn Leu Gly Glu Leu Asn Lys Val Leu Ala His Arg Pro Trp Leu Ile 
            100                 105                 110         


Thr Lys Glu His Ile Glu Gly Leu Leu Lys Ala Glu Glu His Ser Trp 
        115                 120                 125             


Ser Leu Ala Glu Leu Val His Ala Val Val Leu Leu Thr His Tyr His 
    130                 135                 140                 


Ser Leu Ala Ser Phe Thr Phe Gly Cys Gly Ile Ser Pro Glu Ile His 
145                 150                 155                 160 


Cys Asp Gly Gly His Thr Phe Arg Pro Pro Ser Val Ser Asn Tyr Cys 
                165                 170                 175     


Ile Cys Asp Ile Thr Asn Gly Asn His Ser Val Asp Glu Met Pro Val 
            180                 185                 190         


Asn Ser Ala Glu Asn Val Ser Val Ser Asp Ser Phe Phe Glu Val Glu 
        195                 200                 205             


Ala Leu Met Glu Lys Met Arg Gln Leu Gln Glu Cys Arg Asp Glu Glu 
    210                 215                 220                 


Glu Ala Ser Gln Glu Glu Met Ala Ser Arg Phe Glu Ile Glu Lys Arg 
225                 230                 235                 240 


Glu Ser Met Phe Val Phe Ser Ser Asp Asp Glu Glu Val Thr Pro Ala 
                245                 250                 255     


Arg Ala Val Ser Arg His Phe Glu Asp Thr Ser Tyr Gly Tyr Lys Asp 
            260                 265                 270         


Phe Ser Arg His Gly Met His Val Pro Thr Phe Arg Val Gln Asp Tyr 
        275                 280                 285             


Cys Trp Glu Asp His Gly Tyr Ser Leu Val Asn Arg Leu Tyr Pro Asp 
    290                 295                 300                 


Val Gly Gln Leu Ile Asp Glu Lys Phe His Ile Ala Tyr Asn Leu Thr 
305                 310                 315                 320 


Tyr Asn Thr Met Ala Met His Lys Asp Val Asp Thr Ser Met Leu Arg 
                325                 330                 335     


Arg Ala Ile Trp Asn Tyr Ile His Cys Met Phe Gly Ile Arg Tyr Asp 
            340                 345                 350         


Asp Tyr Asp Tyr Gly Glu Ile Asn Gln Leu Leu Asp Arg Ser Phe Lys 
        355                 360                 365             


Val Tyr Ile Lys Thr Val Val Cys Thr Pro Glu Lys Val Thr Lys Arg 
    370                 375                 380                 


Met Tyr Asp Ser Phe Trp Arg Gln Phe Lys His Ser Glu Lys Val His 
385                 390                 395                 400 


Val Asn Leu Leu Leu Ile Glu Ala Arg Met Gln Ala Glu Leu Leu Tyr 
                405                 410                 415     


Ala Leu Arg Ala Ile Thr Arg Tyr Met Thr 
            420                 425     


<210> 11
<211> 353
<212> PRT
<213> Homo sapiens

<400> 11
Met Ser Leu His Thr Gln Tyr Leu Glu Ser Phe Leu Arg Ser Gln Phe 
1               5                   10                  15      


Tyr Met Leu Arg Met Asp Gly Pro Leu Pro Leu Pro Tyr Arg His Tyr 
            20                  25                  30          


Ile Ala Ile Met Lys Leu Val Lys Thr Gly Glu Asn Asn Trp Ser Leu 
        35                  40                  45              


Pro Glu Leu Val His Ala Val Val Leu Leu Ala His Tyr His Ala Leu 
    50                  55                  60                  


Ala Ser Phe Val Phe Gly Ser Gly Ile Asn Pro Glu Arg Asp Pro Glu 
65                  70                  75                  80  


Ile Ser Asn Gly Phe Arg Leu Ile Ser Val Asn Asn Phe Cys Val Cys 
                85                  90                  95      


Asp Leu Ala Asn Asp Asn Asn Ile Glu Asn Ala Ser Leu Ser Gly Ser 
            100                 105                 110         


Asn Phe Gly Ile Val Asp Ser Leu Ser Glu Leu Glu Ala Leu Met Glu 
        115                 120                 125             


Arg Met Lys Arg Leu Gln Glu Glu Arg Glu Asp Glu Glu Ala Ser Gln 
    130                 135                 140                 


Glu Glu Met Ser Thr Arg Phe Glu Lys Glu Lys Lys Glu Ser Leu Phe 
145                 150                 155                 160 


Val Val Ser Gly Asp Thr Phe His Ser Phe Pro His Ser Asp Phe Glu 
                165                 170                 175     


Asp Asp Met Ile Ile Thr Ser Asp Val Ser Arg Tyr Ile Glu Asp Pro 
            180                 185                 190         


Gly Phe Gly Tyr Glu Asp Phe Ala Arg Arg Gly Glu Glu His Leu Pro 
        195                 200                 205             


Thr Phe Arg Ala Gln Asp Tyr Thr Trp Glu Asn His Gly Phe Ser Leu 
    210                 215                 220                 


Val Asn Arg Leu Tyr Ser Asp Ile Gly His Leu Leu Asp Glu Lys Phe 
225                 230                 235                 240 


Arg Met Val Tyr Asn Leu Thr Tyr Asn Thr Met Ala Thr His Glu Asp 
                245                 250                 255     


Val Asp Thr Thr Met Leu Arg Arg Ala Leu Phe Asn Tyr Val His Cys 
            260                 265                 270         


Met Phe Gly Ile Arg Tyr Asp Asp Tyr Asp Tyr Gly Glu Val Asn Gln 
        275                 280                 285             


Leu Leu Glu Arg Ser Leu Lys Val Tyr Ile Lys Thr Val Thr Cys Tyr 
    290                 295                 300                 


Pro Glu Arg Thr Thr Lys Arg Met Tyr Asp Ser Tyr Trp Arg Gln Phe 
305                 310                 315                 320 


Lys His Ser Glu Lys Val His Val Asn Leu Leu Leu Met Glu Ala Arg 
                325                 330                 335     


Met Gln Ala Glu Leu Leu Tyr Ala Leu Arg Ala Ile Thr Arg His Leu 
            340                 345                 350         


Thr 
    


<210> 12
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
caccgatcac atcagtaaac atgag                                             25


<210> 13
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
aaacctcatg tttactgatg tgatc                                             25


<210> 14
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
caccgaccca gggctgtggt cacac                                             25


<210> 15
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
aaacgtgtga ccacagccct gggtc                                             25


<210> 16
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
caccgcgggg gagatggcgg cgcga                                             25


<210> 17
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
aaactcgcgc cgccatctcc cccgc                                             25


<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
caccgtgaac cgcatcgagc tgaa                                              24


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
aaacttcagc tcgatgcggt tcac                                              24


<210> 20
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
caccggcttt caggctccgt tcga                                              24


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
aaactcgaac ggagcctgaa agcc                                              24


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
tggcaatgca caaagatgtt g                                                 21


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
gctacgatcc aatagctggt t                                                 21


<210> 24
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
tgcgtttgtg atcttgctaa tg                                                22


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
cgcctcttca tcttcccttt c                                                 21


<210> 26
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
caccgagagc ctcgagcagc acctg                                             25


<210> 27
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
aaaccaggtg ctgctcgagg ctctc                                             25


<210> 28
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
caccggacta cctgcggttc gccc                                              24


<210> 29
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
aaacgggcga accgcaggta gtcc                                              24


<210> 30
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
caccgccaca gccaaacacg aagg                                              24


<210> 31
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
aaacccttcg tgtttggctg tggc                                              24


