                               SEQUENCE LISTING

<110> WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
 
<120> CELLS EXPRESSING APOLIPOPROTEIN E AND USES THEREOF

<130> 26495-0017WO1

<140> PCT/US2015/049674
<141> 2015-09-11

<150> 62/050,045
<151> 2014-09-12

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1
Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu Arg Gln 
1               5                   10                  15      


Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg 
            20                  25                  30          


Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln Val Gln 
        35                  40                  45              


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
    50                  55                  60                  


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
65                  70                  75                  80  


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
                85                  90                  95      


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Cys 
            100                 105                 110         


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
        115                 120                 125             


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu 
    130                 135                 140                 


Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Cys Leu Ala 
145                 150                 155                 160 


Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu Ser Ala 
                165                 170                 175     


Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val Arg Ala 
            180                 185                 190         


Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg Ala Gln 
        195                 200                 205             


Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg 
    210                 215                 220                 


Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu Val Arg 
225                 230                 235                 240 


Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala Glu Ala 
                245                 250                 255     


Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu Asp Met 
            260                 265                 270         


Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala Val Gly 
        275                 280                 285             


Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
    290                 295                 


<210> 2
<211> 299
<212> PRT
<213> Homo sapiens

<400> 2
Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu Arg Gln 
1               5                   10                  15      


Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg 
            20                  25                  30          


Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln Val Gln 
        35                  40                  45              


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
    50                  55                  60                  


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
65                  70                  75                  80  


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
                85                  90                  95      


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Cys 
            100                 105                 110         


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
        115                 120                 125             


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu 
    130                 135                 140                 


Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala 
145                 150                 155                 160 


Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu Ser Ala 
                165                 170                 175     


Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val Arg Ala 
            180                 185                 190         


Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg Ala Gln 
        195                 200                 205             


Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg 
    210                 215                 220                 


Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu Val Arg 
225                 230                 235                 240 


Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala Glu Ala 
                245                 250                 255     


Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu Asp Met 
            260                 265                 270         


Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala Val Gly 
        275                 280                 285             


Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
    290                 295                 


<210> 3
<211> 299
<212> PRT
<213> Homo sapiens

<400> 3
Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu Arg Gln 
1               5                   10                  15      


Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg 
            20                  25                  30          


Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln Val Gln 
        35                  40                  45              


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
    50                  55                  60                  


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
65                  70                  75                  80  


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
                85                  90                  95      


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg 
            100                 105                 110         


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
        115                 120                 125             


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu 
    130                 135                 140                 


Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala 
145                 150                 155                 160 


Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu Ser Ala 
                165                 170                 175     


Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val Arg Ala 
            180                 185                 190         


Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg Ala Gln 
        195                 200                 205             


Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg 
    210                 215                 220                 


Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu Val Arg 
225                 230                 235                 240 


Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala Glu Ala 
                245                 250                 255     


Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu Asp Met 
            260                 265                 270         


Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala Val Gly 
        275                 280                 285             


Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
    290                 295                 


<210> 4
<211> 42
<212> PRT
<213> Saccharomyces sp.

<400> 4
Met Phe Phe Asn Arg Leu Ser Ala Gly Lys Leu Leu Val Pro Leu Ser 
1               5                   10                  15      


Val Val Leu Tyr Ala Leu Phe Val Val Ile Leu Pro Leu Gln Asn Ser 
            20                  25                  30          


Phe His Ser Ser Asn Val Leu Val Arg Gly 
        35                  40          


<210> 5
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala 
        


<210> 6
<211> 43
<212> PRT
<213> Homo sapiens

<400> 6
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr 
        35                  40              


<210> 7

<400> 7
000


<210> 8
<211> 1028
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atgtttttca acagactaag cgctggcaag ctgctggtac cactctccgt ggtcctgtac       60

gcccttttcg tggtaatatt acctttacag aattctttcc actcctccaa tgttttagtt      120

agaggtaagg tggagcaagc ggtggagaca gagccggagc ccgagctgcg ccagcagacc      180

gagtggcaga gcggccagcg ctgggaactg gcactgggtc gcttttggga ttacctgcgc      240

tgggtgcaga cactgtctga gcaggtgcag gaggagctgc tcagctccca ggtcacccag      300

gaactgaggg cgctgatgga cgagaccatg aaggagttga aggcctacaa atcggaactg      360

gaggaacaac tgaccccggt ggcggaggag acgcgggcac ggctgtccaa ggagctgcag      420

gcggcgcagg cccggctggg cgcggacatg gaggacgtgt gcggccgcct ggtgcagtac      480

cgcggcgagg tgcaggccat gctcggccag agcaccgagg agctgcgggt gcgcctcgcc      540

tcccacctgc gcaagctgcg taagcggctc ctccgcgatg ccgatgacct gcagaagtgc      600

ctggcagtgt accaggccgg ggcccgcgag ggcgccgagc gcggcctcag cgccatccgc      660

gagcgcctgg ggcccctggt ggaacagggc cgcgtgcggg ccgccactgt gggctccctg      720

gccggccagc cgctacagga gcgggcccag gcctggggcg agcggctgcg cgcgcggatg      780

gaggagatgg gcagccggac ccgcgaccgc ctggacgagg tgaaggagca ggtggcggag      840

gtgcgcgcca agctggagga gcaggcccag cagatacgcc tgcaggccga ggccttccag      900

gcccgcctca agagctggtt cgagcccctg gtggaagaca tgcagcgcca gtgggccggg      960

ctggtggaga aggtgcaggc tgccgtgggc accagcgccg cccctgtgcc cagcgacaat     1020

cactgccc                                                              1028


<210> 9
<211> 1028
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atgtttttca acagactaag cgctggcaag ctgctggtac cactctccgt ggtcctgtac       60

gcccttttcg tggtaatatt acctttacag aattctttcc actcctccaa tgttttagtt      120

agaggtaagg tggagcaagc ggtggagaca gagccggagc ccgagctgcg ccagcagacc      180

gagtggcaga gcggccagcg ctgggaactg gcactgggtc gcttttggga ttacctgcgc      240

tgggtgcaga cactgtctga gcaggtgcag gaggagctgc tcagctccca ggtcacccag      300

gaactgaggg cgctgatgga cgagaccatg aaggagttga aggcctacaa atcggaactg      360

gaggaacaac tgaccccggt ggcggaggag acgcgggcac ggctgtccaa ggagctgcag      420

gcggcgcagg cccggctggg cgcggacatg gaggacgtgc gcggccgcct ggtgcagtac      480

cgcggcgagg tgcaggccat gctcggccag agcaccgagg agctgcgggt gcgcctcgcc      540

tcccacctgc gcaagctgcg taagcggctc ctccgcgatg ccgatgacct gcagaagtgc      600

ctggcagtgt accaggccgg ggcccgcgag ggcgccgagc gcggcctcag cgccatccgc      660

gagcgcctgg ggcccctggt ggaacagggc cgcgtgcggg ccgccactgt gggctccctg      720

gccggccagc cgctacagga gcgggcccag gcctggggcg agcggctgcg cgcgcggatg      780

gaggagatgg gcagccggac ccgcgaccgc ctggacgagg tgaaggagca ggtggcggag      840

gtgcgcgcca agctggagga gcaggcccag cagatacgcc tgcaggccga ggccttccag      900

gcccgcctca agagctggtt cgagcccctg gtggaagaca tgcagcgcca gtgggccggg      960

ctggtggaga aggtgcaggc tgccgtgggc accagcgccg cccctgtgcc cagcgacaat     1020

cactgccc                                                              1028


<210> 10
<211> 1028
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atgtttttca acagactaag cgctggcaag ctgctggtac cactctccgt ggtcctgtac       60

gcccttttcg tggtaatatt acctttacag aattctttcc actcctccaa tgttttagtt      120

agaggtaagg tggagcaagc ggtggagaca gagccggagc ccgagctgcg ccagcagacc      180

gagtggcaga gcggccagcg ctgggaactg gcactgggtc gcttttggga ttacctgcgc      240

tgggtgcaga cactgtctga gcaggtgcag gaggagctgc tcagctccca ggtcacccag      300

gaactgaggg cgctgatgga cgagaccatg aaggagttga aggcctacaa atcggaactg      360

gaggaacaac tgaccccggt ggcggaggag acgcgggcac ggctgtccaa ggagctgcag      420

gcggcgcagg cccggctggg cgcggacatg gaggacgtgc gcggccgcct ggtgcagtac      480

cgcggcgagg tgcaggccat gctcggccag agcaccgagg agctgcgggt gcgcctcgcc      540

tcccacctgc gcaagctgcg taagcggctc ctccgcgatg ccgatgacct gcagaagcgc      600

ctggcagtgt accaggccgg ggcccgcgag ggcgccgagc gcggcctcag cgccatccgc      660

gagcgcctgg ggcccctggt ggaacagggc cgcgtgcggg ccgccactgt gggctccctg      720

gccggccagc cgctacagga gcgggcccag gcctggggcg agcggctgcg cgcgcggatg      780

gaggagatgg gcagccggac ccgcgaccgc ctggacgagg tgaaggagca ggtggcggag      840

gtgcgcgcca agctggagga gcaggcccag cagatacgcc tgcaggccga ggccttccag      900

gcccgcctca agagctggtt cgagcccctg gtggaagaca tgcagcgcca gtgggccggg      960

ctggtggaga aggtgcaggc tgccgtgggc accagcgccg cccctgtgcc cagcgacaat     1020

cactgccc                                                              1028


<210> 11
<211> 24
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala 
            20                  


<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 12
His His His His His His 
1               5       


<210> 13
<211> 4
<212> PRT
<213> Saccharomyces sp.

<400> 13
Asp Glu Ala Asp 
1               


