                         SEQUENCE LISTING

<110>  EPIZYME, INC.
       Mitchell, Lorna H
       Foley, Megan  A
       Kuntz, Kevin W
       Munchhof, Michael  J
 
<120>  SUBSTITUTED CYCLOHEXYLAMINE COMPOUNDS 

<130>  3562.002PC01/JMC/MFG

<140>  To be assigned
<141>  Herewith

<150>  62/048,756
<151>  2014-09-10

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein

<400>  1

Met Ala Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Thr Met Asp Asp Gln 
225                 230                 235                 240 


Gln Ala Leu Asn Ser Ile Met Gln Asp Leu Ala Val Leu His Lys Ala 
                245                 250                 255     


Ser Arg Pro Ala Leu Ser Leu Gln Glu Thr Arg Lys Ala Lys Ser Ser 
            260                 265                 270         


Ser Pro Lys Lys Gln Asn Asp Val Arg Val Lys Phe Glu His Arg Gly 
        275                 280                 285             


Glu Lys Arg Ile Leu Gln Phe Pro Arg Pro Val Lys Leu Glu Asp Leu 
    290                 295                 300                 


Arg Ser Lys Ala Lys Ile Ala Phe Gly Gln Ser Met Asp Leu His Tyr 
305                 310                 315                 320 


Thr Asn Asn Glu Leu Val Ile Pro Leu Thr Thr Gln Asp Asp Leu Asp 
                325                 330                 335     


Lys Ala Leu Glu Leu Leu Asp Arg Ser Ile His Met Lys Ser Leu Lys 
            340                 345                 350         


Ile Leu Leu Val Ile Asn Gly Ser Thr Gln Ala Thr Asn Leu Glu Pro 
        355                 360                 365             


Leu Pro Ser Leu Glu Asp Leu Asp Asn Thr Val Phe Gly Ala Glu Arg 
    370                 375                 380                 


Lys Lys Arg Leu Ser Ile Ile Gly Pro Thr Ser Arg Asp Arg Ser Ser 
385                 390                 395                 400 


Pro Pro Pro Gly Tyr Ile Pro Asp Glu Leu His Gln Val Ala Arg Asn 
                405                 410                 415     


Gly Ser Phe Thr Ser Ile Asn Ser Glu Gly Glu Phe Ile Pro Glu Ser 
            420                 425                 430         


Met Glu Gln Met Leu Asp Pro Leu Ser Leu Ser Ser Pro Glu Asn Ser 
        435                 440                 445             


Gly Ser Gly Ser Cys Pro Ser Leu Asp Ser Pro Leu Asp Gly Glu Ser 
    450                 455                 460                 


Tyr Pro Lys Ser Arg Met Pro Arg Ala Gln Ser Tyr Pro Asp Asn His 
465                 470                 475                 480 


Gln Glu Phe Ser Asp Tyr Asp Asn Pro Ile Phe Glu Lys Phe Gly Lys 
                485                 490                 495     


Gly Gly Thr Tyr Pro Arg Arg Tyr His Val Ser Tyr His His Gln Glu 
            500                 505                 510         


Tyr Asn Asp Gly Arg Lys Thr Phe Pro Arg Ala Arg Arg Thr Gln Gly 
        515                 520                 525             


Asn Gln Leu Thr Ser Pro Val Ser Phe Ser Pro Thr Asp His Ser Leu 
    530                 535                 540                 


Ser Thr Ser Ser Gly Ser Ser Ile Phe Thr Pro Glu Tyr Asp Asp Ser 
545                 550                 555                 560 


Arg Ile Arg Arg Arg Gly Ser Asp Ile Asp Asn Pro Thr Leu Thr Val 
                565                 570                 575     


Met Asp Ile Ser Pro Pro Ser Arg Ser Pro Arg Ala Pro Thr Asn Trp 
            580                 585                 590         


Arg Leu Gly Lys Leu Leu Gly Gln Gly Ala Phe Gly Arg Val Tyr Leu 
        595                 600                 605             


Cys Tyr Asp Val Asp Thr Gly Arg Glu Leu Ala Val Lys Gln Val Gln 
    610                 615                 620                 


Phe Asp Pro Asp Ser Pro Glu Thr Ser Lys Glu Val Asn Ala Leu Glu 
625                 630                 635                 640 


Cys Glu Ile Gln Leu Leu Lys Asn Leu Leu His Glu Arg Ile Val Gln 
                645                 650                 655     


Tyr Tyr Gly Cys Leu Arg Asp Pro Gln Glu Lys Thr Leu Ser Ile Phe 
            660                 665                 670         


Met Glu Tyr Met Pro Gly Gly Ser Ile Lys Asp Gln Leu Lys Ala Tyr 
        675                 680                 685             


Gly Ala Leu Thr Glu Asn Val Thr Arg Lys Tyr Thr Arg Gln Ile Leu 
    690                 695                 700                 


Glu Gly Val His Tyr Leu His Ser Asn Met Ile Val His Arg Asp Ile 
705                 710                 715                 720 


Lys Gly Ala Asn Ile Leu Arg Asp Ser Thr Gly Asn Val Lys Leu Gly 
                725                 730                 735     


Asp Phe Gly Ala Ser Lys Arg Leu Gln Thr Ile Cys Leu Ser Gly Thr 
            740                 745                 750         


Gly Met Lys Ser Val Thr Gly Thr Pro Tyr Trp Met Ser Pro Glu Val 
        755                 760                 765             


Ile Ser Gly Gln Gly Tyr Gly Arg Lys Ala Asp Ile Trp Ser Val Ala 
    770                 775                 780                 


Cys Thr Val Val Glu Met Leu Thr Glu Lys Pro Pro Trp Ala Glu Phe 
785                 790                 795                 800 


Glu Ala Met Ala Ala Ile Phe Lys Ile Ala Thr Gln Pro Thr Asn Pro 
                805                 810                 815     


Lys Leu Pro Pro His Val Ser Asp Tyr Thr Arg Asp Phe Leu Lys Arg 
            820                 825                 830         


Ile Phe Val Glu Ala Lys Leu Arg Pro Ser Ala Asp Glu Leu Leu Arg 
        835                 840                 845             


His Met Phe Val His Tyr His 
    850                 855 


<210>  2
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein

<400>  2

Met Glu Pro Leu Lys Val Glu Lys Phe Ala Thr Ala Lys Arg Gly Asn 
1               5                   10                  15      


Gly Leu Arg Ala Val Thr Pro Leu Arg Pro Gly Glu Leu Leu Phe Arg 
            20                  25                  30          


Ser Asp Pro Leu Ala Tyr Thr Val Cys Lys Gly Ser Arg Gly Val Val 
        35                  40                  45              


Cys Asp Arg Cys Leu Leu Gly Lys Glu Lys Leu Met Arg Cys Ser Gln 
    50                  55                  60                  


Cys Arg Val Ala Lys Tyr Cys Ser Ala Lys Cys Gln Lys Lys Ala Trp 
65                  70                  75                  80  


Pro Asp His Lys Arg Glu Cys Lys Cys Leu Lys Ser Cys Lys Pro Arg 
                85                  90                  95      


Tyr Pro Pro Asp Ser Val Arg Leu Leu Gly Arg Val Val Phe Lys Leu 
            100                 105                 110         


Met Asp Gly Ala Pro Ser Glu Ser Glu Lys Leu Tyr Ser Phe Tyr Asp 
        115                 120                 125             


Leu Glu Ser Asn Ile Asn Lys Leu Thr Glu Asp Lys Lys Glu Gly Leu 
    130                 135                 140                 


Arg Gln Leu Val Met Thr Phe Gln His Phe Met Arg Glu Glu Ile Gln 
145                 150                 155                 160 


Asp Ala Ser Gln Leu Pro Pro Ala Phe Asp Leu Phe Glu Ala Phe Ala 
                165                 170                 175     


Lys Val Ile Cys Asn Ser Phe Thr Ile Cys Asn Ala Glu Met Gln Glu 
            180                 185                 190         


Val Gly Val Gly Leu Tyr Pro Ser Ile Ser Leu Leu Asn His Ser Cys 
        195                 200                 205             


Asp Pro Asn Cys Ser Ile Val Phe Asn Gly Pro His Leu Leu Leu Arg 
    210                 215                 220                 


Ala Val Arg Asp Ile Glu Val Gly Glu Glu Leu Thr Ile Cys Tyr Leu 
225                 230                 235                 240 


Asp Met Leu Met Thr Ser Glu Glu Arg Arg Lys Gln Leu Arg Asp Gln 
                245                 250                 255     


Tyr Cys Phe Glu Cys Asp Cys Phe Arg Cys Gln Thr Gln Asp Lys Asp 
            260                 265                 270         


Ala Asp Met Leu Thr Gly Asp Glu Gln Val Trp Lys Glu Val Gln Glu 
        275                 280                 285             


Ser Leu Lys Lys Ile Glu Glu Leu Lys Ala His Trp Lys Trp Glu Gln 
    290                 295                 300                 


Val Leu Ala Met Cys Gln Ala Ile Ile Ser Ser Asn Ser Glu Arg Leu 
305                 310                 315                 320 


Pro Asp Ile Asn Ile Tyr Gln Leu Lys Val Leu Asp Cys Ala Met Asp 
                325                 330                 335     


Ala Cys Ile Asn Leu Gly Leu Leu Glu Glu Ala Leu Phe Tyr Gly Thr 
            340                 345                 350         


Arg Thr Met Glu Pro Tyr Arg Ile Phe Phe Pro Gly Ser His Pro Val 
        355                 360                 365             


Arg Gly Val Gln Val Met Lys Val Gly Lys Leu Gln Leu His Gln Gly 
    370                 375                 380                 


Met Phe Pro Gln Ala Met Lys Asn Leu Arg Leu Ala Phe Asp Ile Met 
385                 390                 395                 400 


Arg Val Thr His Gly Arg Glu His Ser Leu Ile Glu Asp Leu Ile Leu 
                405                 410                 415     


Leu Leu Glu Glu Cys Asp Ala Asn Ile Arg Ala Ser 
            420                 425             


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein


<220>
<221>  MISC_FEATURE
<223>  C-terminal amide cap

<400>  3

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala 
            20                  25                  


