                               SEQUENCE LISTING

<110> HIGGS, BRANDON
      HUANG, JIAQI
      XIAO, ZHAN
      YAO, XIN
      ZHONG, HAIHONG
      CONLEY, SARAH
      YAO, YIHONG
      JIANG, LIYAN
 
<120> COMPOSITIONS AND METHODS FOR DETECTING AND TREATING SMALL CELL 
      LUNG CANCER

<130> SRSF1-100WO1

<140> PCT/US2015/048602
<141> 2015-09-04

<150> 62/047,337
<151> 2014-09-08

<160> 5     

<170> PatentIn version 3.5

<210> 1
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
ccaacaagat agagtataa                                                    19


<210> 2
<211> 248
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 
            180                 185                 190         


Lys Val Asp Gly Pro Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg 
        195                 200                 205             


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg 
    210                 215                 220                 


Ser Tyr Ser Pro Arg Arg Ser Arg Gly Ser Pro Arg Tyr Ser Pro Arg 
225                 230                 235                 240 


His Ser Arg Ser Arg Ser Arg Thr 
                245             


<210> 3
<211> 5468
<212> DNA
<213> Homo sapiens

<400> 3
gttgcgctcc cgcgcgtgcg tgttgggatc gaatcgctgt ttccttccgc ttctcttcct       60

ctgtctcccc cccatatccg tgcgccgagc tgataaaggc gccattttgg aggggccgcg      120

ggagacgtgg tgccgctgcg ggctcgctct gccgtgcgct aggcttggtg ggaaggcctg      180

ttctcgagtc cgcgcttttc gtcaccgcca tgtcgggagg tggtgtgatt cgtggccccg      240

cagggaacaa cgattgccgc atctacgtgg gtaacttacc tccagacatc cgaaccaagg      300

acattgagga cgtgttctac aaatacggcg ctatccgcga catcgacctc aagaatcgcc      360

gcgggggacc gcccttcgcc ttcgttgagt tcgaggaccc gcgagacgcg gaagacgcgg      420

tgtatggtcg cgacggctat gattacgatg ggtaccgtct gcgggtggag tttcctcgaa      480

gcggccgtgg aacaggccga ggcggcggcg ggggtggagg tggcggagct ccccgaggtc      540

gctatggccc cccatccagg cggtctgaaa acagagtggt tgtctctgga ctgcctccaa      600

gtggaagttg gcaggattta aaggatcaca tgcgtgaagc aggtgatgta tgttatgctg      660

atgtttaccg agatggcact ggtgtcgtgg agtttgtacg gaaagaagat atgacctatg      720

cagttcgaaa actggataac actaagttta gatctcatga gggagaaact gcctacatcc      780

gggttaaagt tgatgggccc agaagtccaa gttatggaag atctcgatct cgaagccgta      840

gtcgtagcag aagccgtagc agaagcaaca gcaggagtcg cagttactcc ccaaggagaa      900

gcagaggatc accacgctat tctccccgtc atagcagatc tcgctctcgt acataagatg      960

attggtgaca ctttttgtag aacccatgtt gtatacagtt ttcctttatt cagtacaatc     1020

ttttcatttt ttaattcaaa ctgttttgtt cagaatgggc taaagtgttg aattgcattc     1080

ttgtaatatc cccttgctcc taacatctac attcccttcg tgtctttgat aaattgtatt     1140

ttaagtgatg tcatagacag gattgtttaa atttagttaa ctccatactc ttcagactgt     1200

gatattgtgt aaatgtctat ctgccctggt ttgtgtgaac tgggatgttg ggggtgtttg     1260

tggttatctt acctggggaa gttcttatgt ttatcttgct tttcatgtgt ctttctgtag     1320

acatatctga agagatggat taagaatgct ttggattaag gattgtggag cacatttcaa     1380

tcattttagg attgtcaaaa ggaggattga ggaggatcag atcaataatg gaggcaatgg     1440

tatgactcca agtgctattg tcacagatga aattggcagt attgacctta tactaaaagg     1500

caggggttaa aaatgattat atacattttc cttaaaacac ttgcaaacat tttattcagt     1560

tgtctttagc tacaattgct ttgcttttta aaccttggca attgtggcaa aattatattg     1620

cccattttgt agcaacttat tttgctccct tccccccatt tttgttttaa tagggactaa     1680

tgtgggaaga actggctaat ttgtcacagt gcttagttac aactgttaat gtgtgacctg     1740

ctgttggtgt acatgtgggt acagggtgtt tttaaatcca acaagataga gtataatatc     1800

aatactgcta aatctgcatg tcctctgtgt gactgataga gcgttgctat ttcatttttt     1860

taagacaaaa tgaaagcaaa atatagagtt ccaatgtatt ggtgtagata atctagttgg     1920

gaatactttt aagtctcacc ttccccttta aactaatatt cataattggt tcatatgttt     1980

aaaagacttt aatttacaaa ttaaattgca aatgggagca ttagatttag ttttagactt     2040

aggtgggtag caatgccagt aaacttaaat tacgtaactt cttgcaacca cgaaacctgt     2100

aatacgctgt acagtaacaa gtgttggcat tatcagttga actgtaaata caaaatgctt     2160

cttccaatta gtctctatga tgattaagtt tctaaaattt atctgaacac cattcagaaa     2220

cttgttttgg ggaatttgat agttattgat gtgcatctgt taaactgatg acagacataa     2280

ctcatcattc cccagaaacc ttttttgatt acagtatcta acattttgcc tcctcttttt     2340

tggttttgct ggttataaag gtttggattg gagagggctc actggatccc aatccttgga     2400

gctggatcat tggattcaaa tcataatgtg gataggatag ggaggatgaa ttaccaggat     2460

tcatggagcg ggatcagatt accaggaaca taggagtgga ttcctgcccc aaccaaaccg     2520

cattcgtgtg gattttttta ttcaacttaa ttggctattc caaagatttt ttttttccta     2580

tttttgacga ttggagccct taagatgcac gatggaattg tgttttgcgt tttttggtaa     2640

aaggagcaaa gcgaggacct ggagataaac gctggagcaa tctccttgga aggattcagc     2700

acgagtagat ggtaaacatt taaaggggaa agggggggtt tgtttaaaat agtaaatcag     2760

taagtcactt ctaaatttaa agaaaacaaa attggagttg aagaataagt aggtttccaa     2820

ttggctattg ccgttttctt tgaaaaaata aacatttttt aaaaaactat gcatggttgt     2880

cctttttcct cttcatgtaa gattctaact gggtctatca gttaatcttt aaattgttaa     2940

gtaagataag attttgactc ttgtgttaat gtgttagcaa attaaaagtt cttaaaaggc     3000

aatctaatgg tattagccat cttttattgt taattgtaaa agtcttcagg ggaaagcaaa     3060

aggggagaat aaggcatttg tgtatgtaac ttggtaaatg acggtggggg atggatctag     3120

catctgaaag ataagcttct ctactttgtt ataaagtggt taaaaaacta tagatgctgc     3180

ttattttctg gtggtcatag acaacatagg cttttgtgca aaattggttg atggctacta     3240

atgttcactt ggagatagct tttgatattc tcaatgaaac tcatctcaaa aaaaggtaag     3300

tattaaatgt taacatcagc acagatgtat tagaactgtt ttttgttttt gagacagagt     3360

ctcgctctgt tctccagact ggagggcagt ggtgtgatct aggctcactg caacctccac     3420

ccctggattt gagtgattct cgtgcctcag tctcccaagt agctgagact acaagtgtgt     3480

gccacccttg cccggctaat tttgtatttt tagtagagat gtggtttctc tgtgttaccc     3540

aggctggtcc caaaactcct ggcctcaagt gatctgcctg ccttggcctc ccaaagtgtt     3600

aggattacag gtgtgagcca ccatgctcag cctgtagaac ttttaaccca agtctcattt     3660

cttttttgaa agggaagagt gcacaagatt aactgcttct ttggatgaat cattgttaat     3720

aaaaagctgg gcatttagaa ttttgcctta taagcccttc tccaaccata agattatttt     3780

gtaccaaaaa ctttggtgtt ctctaccaaa gcagttaaaa acttttagcc tgctacttct     3840

tgtatttgtc tactgacagc cccttggtac tatttaggtt gggggagggg acctaaaata     3900

aatagacttt aacatttccc ttgggtgcta atcatagttg gaagttgaat ttaaggtgat     3960

tatttgggtg acaattaaaa acctaaggaa aaccagaaat cttggtagtg gaagaaatgt     4020

gtaaggtcac cccaatcggt agattttaat gaacgttgtg gaatgttggg aagaggggat     4080

gttaagttga atgcagaatt tcactaagta cttagtgtaa gtttaaggat gtagctcttt     4140

ttatctaaga attcaatgta atggccaaaa ggcagattta ctgtttaaaa atttgaataa     4200

ttttacatga cattcttgaa attctaagaa gttttatgtg tagaacattt taaaaattca     4260

tcagattatt aaagggaaaa taaatgatta atgataattt tggaaggtta atgtgagcta     4320

gacttaagta aactttggtt catttgtgtt cattgaatgt tttggaaatg accaaaaaat     4380

gtaaatggcc ttcactcaag tttgagtgtt taaagttgaa agatgtgctc tactaaaagt     4440

tatagtaatt ctaacctcac attgaaatga gacagtattc cttgttatac aggctgaatt     4500

tgaagattag agaggatcta atgtttactt aggtaaaggg gcataggttt tgtagttaag     4560

atgaccagac agctaaaagc tgtgatggga agtatggact gctcctattt atagtctcag     4620

aaaatggacc tttaggtctc tatccgtatt ggcaattatt agaagaaagt tacacccttt     4680

tgaaactaca aaagctgtct tggaatttcc ccctcttctc cctatttatg tccccttaga     4740

atattttagg gagcctataa ttattttcta accaaggaaa aacttaagtc tctttaagaa     4800

gcaattactt ttcataacat cagattgaat aacccacctt gctgttcagc ccacatccta     4860

ctggaaacaa aaggtaagaa acccattttc tggttcttga ttgtttgggt ctgaattttg     4920

tttttaaaac taagctaagt ttaatgtttt ttaaaatgct gtttggaata tgaatagatt     4980

ccccgtaaaa tgatttttcc taagttttat gctttagtaa atattcagtg ctcacgtctg     5040

tgcatcatag tgcttgcgtt taatatgatt tattgtagaa tctcaacttt tcttggtgtt     5100

tgttgtcttt gaaacattgt cttggtcatt agggctggtg ttttcacatt tctgtggtca     5160

aggtggattt cttatgtgtg cctttttgct tactttgtat atgaattttg taatttaaat     5220

tgcaagtaag ttatatatat gtatttacca taaatagtat taaaagatga gaaactgtta     5280

gactgaagtt ctgttgtaac ataaccatta tttccatcac agtatgaaga ctgcaaacgc     5340

agaaaacaga ttacagtctc ttatccattt tttgaaatcc aaaaactacg aaaacaaaag     5400

attttctgtt gttgagctaa ttaaatgtga accctgacca gaaaaaaaaa aaaaaaaaaa     5460

aaaaaaaa                                                              5468


<210> 4
<211> 10
<212> DNA
<213> Homo sapiens

<400> 4
tgcacagggc                                                              10


<210> 5
<211> 10
<212> DNA
<213> Homo sapiens

<400> 5
gccctgtgca                                                              10


