                         SEQUENCE LISTING

<110>  The State of Israel, Ministry of Agriculture & Rural
       Development, Agricultural Research Organization (ARO) 
       (Volcani
       Center)
       ITKIN, Maxim
       Rachel, DAVIDOVICH-RIKANATI
       Shahar, COHEN
       Vitaly, PORTNOY
       Adi, DORON-FAIGENBOIM
       Marina, PETREIKOV
       Shmuel, SHEN
       Yaakov, TADMOR
       Yosef, BURGER
       Efraim, LEWINSOHN
       Nurit, KATZIR
       SCHAFFER, Arthur A
       Elad, OREN
 
<120>  METHODS OF PRODUCING MOGROSIDES AND COMPOSITIONS COMPRISING SAME 
       AND USES THEREOF

<130>  63579

<150>  US 62/048,924
<151>  2014-09-11

<150>  US 62/089,929
<151>  2014-12-10

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  1647
<212>  DNA
<213>  Siraitia grosvenori

<400>  1
atggacgaaa attataattt tttaaaagtt caaaccttca atctcaagaa attcaacaaa       60

aattttccat cgcaacgacg ccgttcacct gcaccaagta actacttcat gtgtacttca      120

cttgctgaat tccttccgtg taaaacgtgg ttccagtttg tctcagcaat attctattta      180

aatggtcctt cgcacgattt ccaccatttg cctgctgcac cgggcggcga ttccgacgga      240

agagagaaga gccgatcgcc ggaaatggac gagacgacgg tgaacggagg gcggagagcg      300

agtgatgtgg tggtgttcgc tttcccgagg cacggccata tgagtccgat gctccaattc      360

tccaagcgtt tggtctccaa aggcctccgc gtcacgtttc tcatcaccac ctctgcaact      420

gaatccctcc gactaaatct tcctccctct tcttctctcg atcttcaagt tatctccgac      480

gtccctgaaa gtaacgacat cgcgacgctc gaagggtatc ttcgaagctt caaggccact      540

gtttccaaaa ccttggcgga tttcatcgac ggaatcggaa atcctccaaa gttcatcgtt      600

tacgattcgg tcatgccgtg ggtgcaggag gtagccagag ggcgcggcct cgatgcggcg      660

ccgtttttca ctcaatcgtc cgccgttaat cacatcctca atcatgtgta cggaggatct      720

ttgagcattc cggccccgga gaacacggca gtttcgcttc cttcgatgcc ggttcttcaa      780

gccgaggatc tgccggcctt ccccgacgac ccagaagtgg ttatgaactt catgaccagt      840

caattctcca atttccagga tgcaaaatgg attttcttca acacattcga tcagctggag      900

tgcaagaaac aaagtcaggt tgttaattgg atggccgaca gatggcccat caagacagtg      960

ggaccgacca ttccatcggc atatttggac gacggtcggt tggaggatga cagggcgttt     1020

ggtctgaatc tcctaaaacc tgaagatggg aagaacacta ggcagtggca gtggttagac     1080

tcaaaagaca ctgcttctgt cctttatatt tcatttggaa gcttggctat cttacaagaa     1140

gaacaagtga aggaactggc atatttcctc aaagacacca atctttcctt cttatgggtc     1200

cttagagact cagaactcca aaagcttccc cacaactttg tacaagagac atcacacaga     1260

ggtctggttg taaactggtg ctctcaacta caagttctgt ctcacagggc tgtaagttgc     1320

tttgtgactc attgtggttg gaattcgacg ctcgaagctt tgagcttggg ggtgccgatg     1380

gtcgcaattc cacagtgggt tgatcaaacg acaaacgcca agttcgttgc agatgtttgg     1440

agagtgggag ttagagtgaa gaagaaggac gaacgcatcg taaccaagga agaactagaa     1500

gcctccatcc gacaggttgt tcaaggagag gggagaaatg agtttaaaca taatgcaatc     1560

aagtggaaga agctggctaa agaagcagtg gatgaaggtg gcagctctga taaaaacatt     1620

gaagaatttg tcaagacaat tgcatga                                         1647


<210>  2
<211>  456
<212>  PRT
<213>  Siraitia grosvenori

<400>  2

Met Asp Glu Thr Thr Val Asn Gly Gly Arg Arg Ala Ser Asp Val Val 
1               5                   10                  15      


Val Phe Ala Phe Pro Arg His Gly His Met Ser Pro Met Leu Gln Phe 
            20                  25                  30          


Ser Lys Arg Leu Val Ser Lys Gly Leu Arg Val Thr Phe Leu Ile Thr 
        35                  40                  45              


Thr Ser Ala Thr Glu Ser Leu Arg Leu Asn Leu Pro Pro Ser Ser Ser 
    50                  55                  60                  


Leu Asp Leu Gln Val Ile Ser Asp Val Pro Glu Ser Asn Asp Ile Ala 
65                  70                  75                  80  


Thr Leu Glu Gly Tyr Leu Arg Ser Phe Lys Ala Thr Val Ser Lys Thr 
                85                  90                  95      


Leu Ala Asp Phe Ile Asp Gly Ile Gly Asn Pro Pro Lys Phe Ile Val 
            100                 105                 110         


Tyr Asp Ser Val Met Pro Trp Val Gln Glu Val Ala Arg Gly Arg Gly 
        115                 120                 125             


Leu Asp Ala Ala Pro Phe Phe Thr Gln Ser Ser Ala Val Asn His Ile 
    130                 135                 140                 


Leu Asn His Val Tyr Gly Gly Ser Leu Ser Ile Pro Ala Pro Glu Asn 
145                 150                 155                 160 


Thr Ala Val Ser Leu Pro Ser Met Pro Val Leu Gln Ala Glu Asp Leu 
                165                 170                 175     


Pro Ala Phe Pro Asp Asp Pro Glu Val Val Met Asn Phe Met Thr Ser 
            180                 185                 190         


Gln Phe Ser Asn Phe Gln Asp Ala Lys Trp Ile Phe Phe Asn Thr Phe 
        195                 200                 205             


Asp Gln Leu Glu Cys Lys Val Val Asn Trp Met Ala Asp Arg Trp Pro 
    210                 215                 220                 


Ile Lys Thr Val Gly Pro Thr Ile Pro Ser Ala Tyr Leu Asp Asp Gly 
225                 230                 235                 240 


Arg Leu Glu Asp Asp Arg Ala Phe Gly Leu Asn Leu Leu Lys Pro Glu 
                245                 250                 255     


Asp Gly Lys Asn Thr Arg Gln Trp Gln Trp Leu Asp Ser Lys Asp Thr 
            260                 265                 270         


Ala Ser Val Leu Tyr Ile Ser Phe Gly Ser Leu Ala Ile Leu Gln Glu 
        275                 280                 285             


Glu Gln Val Lys Glu Leu Ala Tyr Phe Leu Lys Asp Thr Asn Leu Ser 
    290                 295                 300                 


Phe Leu Trp Val Leu Arg Asp Ser Glu Leu Gln Lys Leu Pro His Asn 
305                 310                 315                 320 


Phe Val Gln Glu Thr Ser His Arg Gly Leu Val Val Asn Trp Cys Ser 
                325                 330                 335     


Gln Leu Gln Val Leu Ser His Arg Ala Val Ser Cys Phe Val Thr His 
            340                 345                 350         


Cys Gly Trp Asn Ser Thr Leu Glu Ala Leu Ser Leu Gly Val Pro Met 
        355                 360                 365             


Val Ala Ile Pro Gln Trp Val Asp Gln Thr Thr Asn Ala Lys Phe Val 
    370                 375                 380                 


Ala Asp Val Trp Arg Val Gly Val Arg Val Lys Lys Lys Asp Glu Arg 
385                 390                 395                 400 


Ile Val Thr Lys Glu Glu Leu Glu Ala Ser Ile Arg Gln Val Val Gln 
                405                 410                 415     


Gly Glu Gly Arg Asn Glu Phe Lys His Asn Ala Ile Lys Trp Lys Lys 
            420                 425                 430         


Leu Ala Lys Glu Ala Val Asp Glu Gly Gly Ser Ser Asp Lys Asn Ile 
        435                 440                 445             


Glu Glu Phe Val Lys Thr Ile Ala 
    450                 455     


<210>  3
<211>  1479
<212>  DNA
<213>  Siraitia grosvenori

<400>  3
atggcttctc ttctcagcca gattcacatt gttgtgattc cattgatgac tcaaggtcac       60

ctgatccctg cagccgacat ggcaaagcta ttggcagagc gcggcgttac cgtcactatc      120

atcaccaccc ctctcaacgc caagcggatt cagacgctcg ttgatcgcgc tcgagaggcc      180

aatctcgatc tccgacttgt cgaccgactc aacattccgc tcgctgagtt cggcttgccg      240

gaagggtgtg agagcgtaga tcgagtcccc tcgcgggaac tgtttaagaa tttctttttg      300

gctctcaacg acttgcaaaa acccctcgag aggctcgtcg ctaggttgca accacgcccc      360

agctgcgtaa ttgctgataa aaatctgcca tgggtggtag gtgtttgtga aaagttccaa      420

gtgacgaggt tttcgtttga tggcactagt tgtttttctc tgttatgttc taacaacata      480

cgtgcgtcta aggtcctcga gagtgtgaat tcggtatcag agagcttttt ggttcctggg      540

ttacctgata ggattgaagt tactgcagct caattaccag cagacttgaa tccaggttca      600

tatttaaaag agctacatga aagtggaaga attgctcatg agaatgccta tgggttgctg      660

gttaatagtt tcgaggagtt ggaatctgaa tacttgaagg aatatcgaaa ggtgaaaggc      720

gataaaatct ggtgcattgg ccctgtgtcc ctatccaata agacaggcgt ggaaagggcc      780

caacgcggcg gcatagccgc acaagatgct gacaagtgct tgcgctggct cgattcatgg      840

cctaagagct ctgttgttta cgtttgtatt gggagcctca gccggctttc atctcaacaa      900

agttcagagc ttgctttagc cttagaagaa tcaaaccaac cattcatttg ggtcgtaaag      960

gaagaggaga agcatgaaac atcaaagact acatcgacgg tcggatccat gagagctttt     1020

gaagaaagga cgaagggaag agggattctg ctgaagggtt gggctccgca gctgcagatc     1080

ttgtcgcacc cggccgtcgg agcatttcta acccactgcg gctggaactc tgttctggaa     1140

ggcgtctgcg ccggtgttcc attgatcaca tggcccatgt tcgccgacca gttctttaac     1200

gagaaggaag ttgttgaagt tttgaagatt ggggaagaag ttggaaacaa gaagacggtg     1260

ccattggggg atgaagagaa gagcgaggtg gtgatcggca gagaggagat taagaaggct     1320

attggtgcgg taatggagga aggagcagag gcagagagaa gaaagagagc gagaaggctg     1380

gctgagaagg caaacaaagc tatggaagat ggggggagtt cttatgttaa tgttacacga     1440

ttggttgaac atatcaagca actggtgctt gaaaaatga                            1479


<210>  4
<211>  492
<212>  PRT
<213>  Siraitia grosvenori

<400>  4

Met Ala Ser Leu Leu Ser Gln Ile His Ile Val Val Ile Pro Leu Met 
1               5                   10                  15      


Thr Gln Gly His Leu Ile Pro Ala Ala Asp Met Ala Lys Leu Leu Ala 
            20                  25                  30          


Glu Arg Gly Val Thr Val Thr Ile Ile Thr Thr Pro Leu Asn Ala Lys 
        35                  40                  45              


Arg Ile Gln Thr Leu Val Asp Arg Ala Arg Glu Ala Asn Leu Asp Leu 
    50                  55                  60                  


Arg Leu Val Asp Arg Leu Asn Ile Pro Leu Ala Glu Phe Gly Leu Pro 
65                  70                  75                  80  


Glu Gly Cys Glu Ser Val Asp Arg Val Pro Ser Arg Glu Leu Phe Lys 
                85                  90                  95      


Asn Phe Phe Leu Ala Leu Asn Asp Leu Gln Lys Pro Leu Glu Arg Leu 
            100                 105                 110         


Val Ala Arg Leu Gln Pro Arg Pro Ser Cys Val Ile Ala Asp Lys Asn 
        115                 120                 125             


Leu Pro Trp Val Val Gly Val Cys Glu Lys Phe Gln Val Thr Arg Phe 
    130                 135                 140                 


Ser Phe Asp Gly Thr Ser Cys Phe Ser Leu Leu Cys Ser Asn Asn Ile 
145                 150                 155                 160 


Arg Ala Ser Lys Val Leu Glu Ser Val Asn Ser Val Ser Glu Ser Phe 
                165                 170                 175     


Leu Val Pro Gly Leu Pro Asp Arg Ile Glu Val Thr Ala Ala Gln Leu 
            180                 185                 190         


Pro Ala Asp Leu Asn Pro Gly Ser Tyr Leu Lys Glu Leu His Glu Ser 
        195                 200                 205             


Gly Arg Ile Ala His Glu Asn Ala Tyr Gly Leu Leu Val Asn Ser Phe 
    210                 215                 220                 


Glu Glu Leu Glu Ser Glu Tyr Leu Lys Glu Tyr Arg Lys Val Lys Gly 
225                 230                 235                 240 


Asp Lys Ile Trp Cys Ile Gly Pro Val Ser Leu Ser Asn Lys Thr Gly 
                245                 250                 255     


Val Glu Arg Ala Gln Arg Gly Gly Ile Ala Ala Gln Asp Ala Asp Lys 
            260                 265                 270         


Cys Leu Arg Trp Leu Asp Ser Trp Pro Lys Ser Ser Val Val Tyr Val 
        275                 280                 285             


Cys Ile Gly Ser Leu Ser Arg Leu Ser Ser Gln Gln Ser Ser Glu Leu 
    290                 295                 300                 


Ala Leu Ala Leu Glu Glu Ser Asn Gln Pro Phe Ile Trp Val Val Lys 
305                 310                 315                 320 


Glu Glu Glu Lys His Glu Thr Ser Lys Thr Thr Ser Thr Val Gly Ser 
                325                 330                 335     


Met Arg Ala Phe Glu Glu Arg Thr Lys Gly Arg Gly Ile Leu Leu Lys 
            340                 345                 350         


Gly Trp Ala Pro Gln Leu Gln Ile Leu Ser His Pro Ala Val Gly Ala 
        355                 360                 365             


Phe Leu Thr His Cys Gly Trp Asn Ser Val Leu Glu Gly Val Cys Ala 
    370                 375                 380                 


Gly Val Pro Leu Ile Thr Trp Pro Met Phe Ala Asp Gln Phe Phe Asn 
385                 390                 395                 400 


Glu Lys Glu Val Val Glu Val Leu Lys Ile Gly Glu Glu Val Gly Asn 
                405                 410                 415     


Lys Lys Thr Val Pro Leu Gly Asp Glu Glu Lys Ser Glu Val Val Ile 
            420                 425                 430         


Gly Arg Glu Glu Ile Lys Lys Ala Ile Gly Ala Val Met Glu Glu Gly 
        435                 440                 445             


Ala Glu Ala Glu Arg Arg Lys Arg Ala Arg Arg Leu Ala Glu Lys Ala 
    450                 455                 460                 


Asn Lys Ala Met Glu Asp Gly Gly Ser Ser Tyr Val Asn Val Thr Arg 
465                 470                 475                 480 


Leu Val Glu His Ile Lys Gln Leu Val Leu Glu Lys 
                485                 490         


<210>  5
<211>  1362
<212>  DNA
<213>  Siraitia grosvenori

<400>  5
atggatgccc agcgaggtca caccacaacc attttgatgt ttccatggct cggctatggc       60

catctttcgg ctttcctaga gttggccaaa agcctctcaa ggaggaactt ccatatctac      120

ttctgttcaa cctctgttaa cctcgacgcc attaaaccaa agcttccttc ttcttcctct      180

tctgattcca tccaacttgt ggaactttgt cttccatctt ctcctgatca gctccctcct      240

catcttcaca caaccaacgc cctcccccct cacctcatgc ccactctcca ccaagccttc      300

tccatggctg cccaacactt tgctgccatt ttacacacac ttgctccgca tctcctcatt      360

tacgactctt tccaaccttg ggctcctcaa ctagcttcat ccctcaacat tccagccatc      420

aacttcaata ctacgggagc ttcagtcctg acccgaatgc ttcacgctac tcactaccca      480

agttctaaat tcccaatttc agagtttgtt ctccacgatt attggaaagc catgtacagc      540

gccgccggtg gggctgttac aaaaaaagac cacaaaattg gagaaacact tgcgaattgc      600

ttgcatgctt cttgtagtgt aattctaatc aatagtttca gagagctcga ggagaaatat      660

atggattatc tctccgttct cttgaacaag aaagttgttc cggttggtcc tttggtttac      720

gaaccgaatc aagacgggga agatgaaggt tattcaagca tcaaaaattg gcttgacaaa      780

aaggaaccgt cctccaccgt cttcgtttca tttggaagcg aatacttccc gtcaaaggaa      840

gaaatggaag agatagccca tgggttagag gcgagcgagg ttcatttcat ctgggtcgtt      900

aggtttcctc aaggagacaa caccagcgcc attgaagatg ccttgccgaa ggggtttctg      960

gagagggtgg gagagagagg gatggtggtg aagggttggg ctcctcaggc gaagatactg     1020

aagcattgga gcacaggggg attcgtgagc cactgtggat ggaactcggt gatggaaagc     1080

atgatgtttg gcgttcccat aataggggtt ccgatgcatc tggaccagcc ctttaacgcc     1140

ggactcgcgg aagaagctgg cgtcggcgtg gaggccaagc gagatccaga cggcaaaatt     1200

caaagagacg aagttgcaaa gttgatcaaa gaagtggtgg ttgagaaaac cagagaagac     1260

gtgcggaaga aagcaagaga aatgagtgag attttgagga gcaaaggaga ggagaagatg     1320

gatgagatgg tggctgcaat ctctctcttt cttaaaatat ga                        1362


<210>  6
<211>  453
<212>  PRT
<213>  Siraitia grosvenori

<400>  6

Met Asp Ala Gln Arg Gly His Thr Thr Thr Ile Leu Met Phe Pro Trp 
1               5                   10                  15      


Leu Gly Tyr Gly His Leu Ser Ala Phe Leu Glu Leu Ala Lys Ser Leu 
            20                  25                  30          


Ser Arg Arg Asn Phe His Ile Tyr Phe Cys Ser Thr Ser Val Asn Leu 
        35                  40                  45              


Asp Ala Ile Lys Pro Lys Leu Pro Ser Ser Ser Ser Ser Asp Ser Ile 
    50                  55                  60                  


Gln Leu Val Glu Leu Cys Leu Pro Ser Ser Pro Asp Gln Leu Pro Pro 
65                  70                  75                  80  


His Leu His Thr Thr Asn Ala Leu Pro Pro His Leu Met Pro Thr Leu 
                85                  90                  95      


His Gln Ala Phe Ser Met Ala Ala Gln His Phe Ala Ala Ile Leu His 
            100                 105                 110         


Thr Leu Ala Pro His Leu Leu Ile Tyr Asp Ser Phe Gln Pro Trp Ala 
        115                 120                 125             


Pro Gln Leu Ala Ser Ser Leu Asn Ile Pro Ala Ile Asn Phe Asn Thr 
    130                 135                 140                 


Thr Gly Ala Ser Val Leu Thr Arg Met Leu His Ala Thr His Tyr Pro 
145                 150                 155                 160 


Ser Ser Lys Phe Pro Ile Ser Glu Phe Val Leu His Asp Tyr Trp Lys 
                165                 170                 175     


Ala Met Tyr Ser Ala Ala Gly Gly Ala Val Thr Lys Lys Asp His Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Ala Asn Cys Leu His Ala Ser Cys Ser Val Ile 
        195                 200                 205             


Leu Ile Asn Ser Phe Arg Glu Leu Glu Glu Lys Tyr Met Asp Tyr Leu 
    210                 215                 220                 


Ser Val Leu Leu Asn Lys Lys Val Val Pro Val Gly Pro Leu Val Tyr 
225                 230                 235                 240 


Glu Pro Asn Gln Asp Gly Glu Asp Glu Gly Tyr Ser Ser Ile Lys Asn 
                245                 250                 255     


Trp Leu Asp Lys Lys Glu Pro Ser Ser Thr Val Phe Val Ser Phe Gly 
            260                 265                 270         


Ser Glu Tyr Phe Pro Ser Lys Glu Glu Met Glu Glu Ile Ala His Gly 
        275                 280                 285             


Leu Glu Ala Ser Glu Val His Phe Ile Trp Val Val Arg Phe Pro Gln 
    290                 295                 300                 


Gly Asp Asn Thr Ser Ala Ile Glu Asp Ala Leu Pro Lys Gly Phe Leu 
305                 310                 315                 320 


Glu Arg Val Gly Glu Arg Gly Met Val Val Lys Gly Trp Ala Pro Gln 
                325                 330                 335     


Ala Lys Ile Leu Lys His Trp Ser Thr Gly Gly Phe Val Ser His Cys 
            340                 345                 350         


Gly Trp Asn Ser Val Met Glu Ser Met Met Phe Gly Val Pro Ile Ile 
        355                 360                 365             


Gly Val Pro Met His Leu Asp Gln Pro Phe Asn Ala Gly Leu Ala Glu 
    370                 375                 380                 


Glu Ala Gly Val Gly Val Glu Ala Lys Arg Asp Pro Asp Gly Lys Ile 
385                 390                 395                 400 


Gln Arg Asp Glu Val Ala Lys Leu Ile Lys Glu Val Val Val Glu Lys 
                405                 410                 415     


Thr Arg Glu Asp Val Arg Lys Lys Ala Arg Glu Met Ser Glu Ile Leu 
            420                 425                 430         


Arg Ser Lys Gly Glu Glu Lys Met Asp Glu Met Val Ala Ala Ile Ser 
        435                 440                 445             


Leu Phe Leu Lys Ile 
    450             


<210>  7
<211>  1476
<212>  DNA
<213>  Siraitia grosvenori

<400>  7
atgggctccg ccggcgtcga actgaaggtg gctttcctgc catttgcagc tccaggtcac       60

atgattccct tgatgaacat agccagactc ttcgccatgc acggcgccga cgtcaccttc      120

atcaccaccc cggccactgc ctcccgcttc caaaacgtcg tcgactccga tctccgacgc      180

ggccacaaaa tcaaactcca tacatttcaa ctgccctctg cagaagccgg tctccccccc      240

ggcgtcgaga gcttcaacga atgcacttct aaagagatga ccgaaaaact cttcggcgca      300

tttgaaatgc tcaacggaga catcgaacag ttcctcaaag gggctaaagt cgactgcatt      360

gtgagcgata cgattctcgt ttggaccttg gacgccgctg caaggctcgg gattccgagg      420

atagctttcc gatcttcagg attcttttcg gaatgtattc atcactcttt aaggtgtcac      480

aagcctcaca agaaggtggg atccgataca gagccgttta tatttcctgg tttaccgcat      540

aagattgaga taacgagatt gaatatacca caatggtatt cagaagaagg ctatattcag      600

catattgaaa agatgaaaga aatggacaaa aagagttatg cggtactgct aaataccttc      660

tatgagcttg aggctgatta tgttgaatat tttgaatctg ttattgggtt gaaaacatgg      720

atcgtagggc cagtttcctt atgggctaac gagggtggag gcaaaaacga ctcaagaact      780

gagaacaaca acgctgagtt gatggaatgg ctggactcca aacagcctaa ttcagttctg      840

tatgttagtt ttggtagcat gacgaagttc ccatctgctc aggtgctcga aatagctcac      900

ggccttgaag attctggctg ccatttcatt tgggtggttc gaaagatgaa cgaaagtgaa      960

gcagctgatg aagaatttcc agaggggttc gaggagagag tgagagagag caagagaggt     1020

ttgatcataa gagattgggc gccgcaagaa ttgattttga atcatgcagc tgttgggggg     1080

tttgtcactc actgtggctg gaattcaatt ctcgaaagtg tatgtgctgg tcggccgatc     1140

atcgcgtggc cgttgtcggc ggaacagttt ttcaacgaga agtttgtaac tcgtgtattg     1200

aaagttggag tttcaattgg tgtaagaaaa tggtggggct cgacgagttc agaaacttta     1260

gatgtggtga aaagggatcg aattgcagaa gcagtggcga ggttgatggg agatgacaga     1320

gaggtggttg aaatgagaga tggagttaga gaactttcac atgcagcgaa gagagcaata     1380

aaggaaggtg gatcttctca ctcaaccttg ctctcattga tccatgaact caagaccatg     1440

aaatttaaac gccaaagtag taatgtggat ggataa                               1476


<210>  8
<211>  491
<212>  PRT
<213>  Siraitia grosvenori

<400>  8

Met Gly Ser Ala Gly Val Glu Leu Lys Val Ala Phe Leu Pro Phe Ala 
1               5                   10                  15      


Ala Pro Gly His Met Ile Pro Leu Met Asn Ile Ala Arg Leu Phe Ala 
            20                  25                  30          


Met His Gly Ala Asp Val Thr Phe Ile Thr Thr Pro Ala Thr Ala Ser 
        35                  40                  45              


Arg Phe Gln Asn Val Val Asp Ser Asp Leu Arg Arg Gly His Lys Ile 
    50                  55                  60                  


Lys Leu His Thr Phe Gln Leu Pro Ser Ala Glu Ala Gly Leu Pro Pro 
65                  70                  75                  80  


Gly Val Glu Ser Phe Asn Glu Cys Thr Ser Lys Glu Met Thr Glu Lys 
                85                  90                  95      


Leu Phe Gly Ala Phe Glu Met Leu Asn Gly Asp Ile Glu Gln Phe Leu 
            100                 105                 110         


Lys Gly Ala Lys Val Asp Cys Ile Val Ser Asp Thr Ile Leu Val Trp 
        115                 120                 125             


Thr Leu Asp Ala Ala Ala Arg Leu Gly Ile Pro Arg Ile Ala Phe Arg 
    130                 135                 140                 


Ser Ser Gly Phe Phe Ser Glu Cys Ile His His Ser Leu Arg Cys His 
145                 150                 155                 160 


Lys Pro His Lys Lys Val Gly Ser Asp Thr Glu Pro Phe Ile Phe Pro 
                165                 170                 175     


Gly Leu Pro His Lys Ile Glu Ile Thr Arg Leu Asn Ile Pro Gln Trp 
            180                 185                 190         


Tyr Ser Glu Glu Gly Tyr Ile Gln His Ile Glu Lys Met Lys Glu Met 
        195                 200                 205             


Asp Lys Lys Ser Tyr Ala Val Leu Leu Asn Thr Phe Tyr Glu Leu Glu 
    210                 215                 220                 


Ala Asp Tyr Val Glu Tyr Phe Glu Ser Val Ile Gly Leu Lys Thr Trp 
225                 230                 235                 240 


Ile Val Gly Pro Val Ser Leu Trp Ala Asn Glu Gly Gly Gly Lys Asn 
                245                 250                 255     


Asp Ser Arg Thr Glu Asn Asn Asn Ala Glu Leu Met Glu Trp Leu Asp 
            260                 265                 270         


Ser Lys Gln Pro Asn Ser Val Leu Tyr Val Ser Phe Gly Ser Met Thr 
        275                 280                 285             


Lys Phe Pro Ser Ala Gln Val Leu Glu Ile Ala His Gly Leu Glu Asp 
    290                 295                 300                 


Ser Gly Cys His Phe Ile Trp Val Val Arg Lys Met Asn Glu Ser Glu 
305                 310                 315                 320 


Ala Ala Asp Glu Glu Phe Pro Glu Gly Phe Glu Glu Arg Val Arg Glu 
                325                 330                 335     


Ser Lys Arg Gly Leu Ile Ile Arg Asp Trp Ala Pro Gln Glu Leu Ile 
            340                 345                 350         


Leu Asn His Ala Ala Val Gly Gly Phe Val Thr His Cys Gly Trp Asn 
        355                 360                 365             


Ser Ile Leu Glu Ser Val Cys Ala Gly Arg Pro Ile Ile Ala Trp Pro 
    370                 375                 380                 


Leu Ser Ala Glu Gln Phe Phe Asn Glu Lys Phe Val Thr Arg Val Leu 
385                 390                 395                 400 


Lys Val Gly Val Ser Ile Gly Val Arg Lys Trp Trp Gly Ser Thr Ser 
                405                 410                 415     


Ser Glu Thr Leu Asp Val Val Lys Arg Asp Arg Ile Ala Glu Ala Val 
            420                 425                 430         


Ala Arg Leu Met Gly Asp Asp Arg Glu Val Val Glu Met Arg Asp Gly 
        435                 440                 445             


Val Arg Glu Leu Ser His Ala Ala Lys Arg Ala Ile Lys Glu Gly Gly 
    450                 455                 460                 


Ser Ser His Ser Thr Leu Leu Ser Leu Ile His Glu Leu Lys Thr Met 
465                 470                 475                 480 


Lys Phe Lys Arg Gln Ser Ser Asn Val Asp Gly 
                485                 490     


<210>  9
<211>  1422
<212>  DNA
<213>  Siraitia grosvenori

<400>  9
atgtggactg tcgtgctcgg tttggcgacg ctgtttgtcg cctactacat ccattggatt       60

aacaaatgga gagattccaa gttcaacgga gttctgccgc cgggcaccat gggtttgccg      120

ctcatcggag agacgattca actgagtcga cccagtgact ccctcgacgt tcaccctttc      180

atccagaaaa aagttgaaag atacgggccg atcttcaaaa catgtctggc cggaaggccg      240

gtggtggtgt cggcggacgc agagttcaac aactacataa tgctgcagga aggaagagca      300

gtggaaatgt ggtatttgga tacgctctcc aaatttttcg gcctcgacac cgagtggctc      360

aaagctctgg gcctcatcca caagtacatc agaagcatta ctctcaatca cttcggcgcc      420

gaggccctgc gggagagatt tcttcctttt attgaagcat cctccatgga agcccttcac      480

tcctggtcta ctcaacctag cgtcgaagtc aaaaatgcct ccgctctcat ggtttttagg      540

acctcggtga ataagatgtt cggtgaggat gcgaagaagc tatcgggaaa tatccctggg      600

aagttcacga agcttctagg aggatttctc agtttaccac tgaattttcc cggcaccacc      660

taccacaaat gcttgaagga tatgaaggaa atccagaaga agctaagaga ggttgtagac      720

gatagattgg ctaatgtggg ccctgatgtg gaagatttct tggggcaagc ccttaaagat      780

aaggaatcag agaagttcat ttcagaggag ttcatcatcc aactgttgtt ttctatcagt      840

tttgctagct ttgagtccat ctccaccact cttactttga ttctcaagct ccttgatgaa      900

cacccagaag tagtgaaaga gttggaagct gaacacgagg cgattcgaaa agctagagca      960

gatccagatg gaccaattac ttgggaagaa tacaaatcca tgacttttac attacaagtc     1020

atcaatgaaa ccctaaggtt ggggagtgtc acacctgcct tgttgaggaa aacagttaaa     1080

gatcttcaag taaaaggata cataatcccg gaaggatgga caataatgct tgtcaccgct     1140

tcacgtcaca gagacccaaa agtctataag gaccctcata tcttcaatcc atggcgttgg     1200

aaggacttgg actcaattac catccaaaag aacttcatgc cttttggggg aggcttaagg     1260

cattgtgctg gtgctgagta ctctaaagtc tacttgtgca ccttcttgca catcctctgt     1320

accaaatacc gatggaccaa acttggggga ggaaggattg caagagctca tatattgagt     1380

tttgaagatg ggttacatgt gaagttcaca cccaaggaat ga                        1422


<210>  10
<211>  473
<212>  PRT
<213>  Siraitia grosvenori

<400>  10

Met Trp Thr Val Val Leu Gly Leu Ala Thr Leu Phe Val Ala Tyr Tyr 
1               5                   10                  15      


Ile His Trp Ile Asn Lys Trp Arg Asp Ser Lys Phe Asn Gly Val Leu 
            20                  25                  30          


Pro Pro Gly Thr Met Gly Leu Pro Leu Ile Gly Glu Thr Ile Gln Leu 
        35                  40                  45              


Ser Arg Pro Ser Asp Ser Leu Asp Val His Pro Phe Ile Gln Lys Lys 
    50                  55                  60                  


Val Glu Arg Tyr Gly Pro Ile Phe Lys Thr Cys Leu Ala Gly Arg Pro 
65                  70                  75                  80  


Val Val Val Ser Ala Asp Ala Glu Phe Asn Asn Tyr Ile Met Leu Gln 
                85                  90                  95      


Glu Gly Arg Ala Val Glu Met Trp Tyr Leu Asp Thr Leu Ser Lys Phe 
            100                 105                 110         


Phe Gly Leu Asp Thr Glu Trp Leu Lys Ala Leu Gly Leu Ile His Lys 
        115                 120                 125             


Tyr Ile Arg Ser Ile Thr Leu Asn His Phe Gly Ala Glu Ala Leu Arg 
    130                 135                 140                 


Glu Arg Phe Leu Pro Phe Ile Glu Ala Ser Ser Met Glu Ala Leu His 
145                 150                 155                 160 


Ser Trp Ser Thr Gln Pro Ser Val Glu Val Lys Asn Ala Ser Ala Leu 
                165                 170                 175     


Met Val Phe Arg Thr Ser Val Asn Lys Met Phe Gly Glu Asp Ala Lys 
            180                 185                 190         


Lys Leu Ser Gly Asn Ile Pro Gly Lys Phe Thr Lys Leu Leu Gly Gly 
        195                 200                 205             


Phe Leu Ser Leu Pro Leu Asn Phe Pro Gly Thr Thr Tyr His Lys Cys 
    210                 215                 220                 


Leu Lys Asp Met Lys Glu Ile Gln Lys Lys Leu Arg Glu Val Val Asp 
225                 230                 235                 240 


Asp Arg Leu Ala Asn Val Gly Pro Asp Val Glu Asp Phe Leu Gly Gln 
                245                 250                 255     


Ala Leu Lys Asp Lys Glu Ser Glu Lys Phe Ile Ser Glu Glu Phe Ile 
            260                 265                 270         


Ile Gln Leu Leu Phe Ser Ile Ser Phe Ala Ser Phe Glu Ser Ile Ser 
        275                 280                 285             


Thr Thr Leu Thr Leu Ile Leu Lys Leu Leu Asp Glu His Pro Glu Val 
    290                 295                 300                 


Val Lys Glu Leu Glu Ala Glu His Glu Ala Ile Arg Lys Ala Arg Ala 
305                 310                 315                 320 


Asp Pro Asp Gly Pro Ile Thr Trp Glu Glu Tyr Lys Ser Met Thr Phe 
                325                 330                 335     


Thr Leu Gln Val Ile Asn Glu Thr Leu Arg Leu Gly Ser Val Thr Pro 
            340                 345                 350         


Ala Leu Leu Arg Lys Thr Val Lys Asp Leu Gln Val Lys Gly Tyr Ile 
        355                 360                 365             


Ile Pro Glu Gly Trp Thr Ile Met Leu Val Thr Ala Ser Arg His Arg 
    370                 375                 380                 


Asp Pro Lys Val Tyr Lys Asp Pro His Ile Phe Asn Pro Trp Arg Trp 
385                 390                 395                 400 


Lys Asp Leu Asp Ser Ile Thr Ile Gln Lys Asn Phe Met Pro Phe Gly 
                405                 410                 415     


Gly Gly Leu Arg His Cys Ala Gly Ala Glu Tyr Ser Lys Val Tyr Leu 
            420                 425                 430         


Cys Thr Phe Leu His Ile Leu Cys Thr Lys Tyr Arg Trp Thr Lys Leu 
        435                 440                 445             


Gly Gly Gly Arg Ile Ala Arg Ala His Ile Leu Ser Phe Glu Asp Gly 
    450                 455                 460                 


Leu His Val Lys Phe Thr Pro Lys Glu 
465                 470             


<210>  11
<211>  2277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised Nucleic Acid sequence encoding SgCDS cucurbitadienol 
       synthase

<400>  11
atgtggaggt taaaggtcgg agcggaatcc gttggtgaga acgacgaaaa atggttaaag       60

tcaatatcaa accatttggg taggcaagtt tgggaatttt gtccagatgc gggtactcaa      120

caacagctgc tacaagttca taaagcacgt aaagctttcc acgatgaccg tttccacaga      180

aaacagtcat cagacttgtt catcacgatc cagtacggca aagaggttga aaacggaggc      240

aaaaccgctg gagtaaaatt aaaagaaggc gaggaagtca ggaaagaagc cgtagaaagc      300

tcacttgaaa gagctctatc tttttactca tctatacaaa cgagtgacgg aaactgggct      360

tccgatctag gtggaccaat gttcttactg cctggtttag ttattgcact ttatgtcaca      420

ggggttttaa actccgtatt atctaaacat catagacaag agatgtgtag atacgtttat      480

aatcatcaaa acgaggatgg cggatggggg ttacacatcg agggaccttc aacaatgttt      540

ggttcagctc taaactatgt agctcttagg ttattgggcg aagatgctaa tgctggtgca      600

atgcccaaag caagagcatg gatcttagat catggaggtg ccacggggat tacaagttgg      660

gggaaattgt ggctaagtgt tctgggtgta tatgagtggt ccggaaataa tccactacca      720

cccgaattct ggttatttcc atactttctg ccttttcatc caggcagaat gtggtgtcat      780

tgcagaatgg tctatttacc tatgagttac ctatacggta aaagattcgt aggtccaatt      840

actcccatcg tgttgtcttt gagaaaggaa ttatacgcag ttccgtatca cgaaattgac      900

tggaataaat ctagaaatac ttgtgctaaa gaagatctat actatcctca tcccaagatg      960

caagacattt tgtggggaag tttacaccat gtctatgaac ccttatttac aagatggcct     1020

gcgaaaagat tgagagaaaa agcgctacag actgccatgc agcatattca ttatgaagat     1080

gaaaacacaa gatatatttg tttaggacct gtaaataaag tattgaatct tttatgttgt     1140

tgggttgaag acccttattc agacgccttc aagttgcatt tacaaagagt acatgactac     1200

ttatgggtcg ctgaagacgg aatgaaaatg caaggctata atggaagtca gctgtgggac     1260

acagcctttt caatacaagc aattgtttct accaagctag tagataacta cggcccaact     1320

ttgagaaagg cccatgactt tgttaagtcc agccagatcc aacaagattg tcctggtgat     1380

ccaaacgtct ggtataggca tattcacaag ggtgcctggc cctttagcac tagagaccat     1440

ggttggttga tttccgactg tacggccgaa ggcttaaaag ctgcattgat gctaagtaag     1500

ttaccctccg aaacagtagg ggagagttta gaaagaaata gactatgcga cgctgtaaat     1560

gtcttattat ctttacaaaa cgacaatgga ggttttgctt catacgaatt aacaagatcc     1620

tacccttggt tagaactgat taacccagct gaaacttttg gtgatattgt catcgattat     1680

ccctatgttg aatgtacgtc tgcgactatg gaagccttga ctttatttaa gaaacttcat     1740

ccaggccaca ggactaagga gatagatact gctattgttc gtgcggctaa cttcttggaa     1800

aacatgcaaa gaactgatgg aagttggtac ggttgttggg gggtgtgttt cacatatgct     1860

ggctggtttg gaataaaggg tttggttgcc gctgggagaa cgtataataa ttgtttagca     1920

ataaggaaag cttgcgactt tcttttgagt aaggaattac ctggcggtgg atggggagag     1980

tcttaccttt catgccaaaa taaggtgtac acgaacctag aaggtaatag acctcacttg     2040

gtaaataccg cctgggtttt aatggccttg atcgaagcag gacaagccga gagagatcca     2100

acaccattgc atcgtgctgc cagactatta ataaatagtc aactagagaa cggtgacttc     2160

ccacagcaag aaatcatggg tgtttttaat aaaaactgta tgataactta tgccgcatat     2220

cgtaatatat tcccaatttg ggcgttagga gagtattgtc acagagtact tactgaa        2277


<210>  12
<211>  759
<212>  PRT
<213>  Siraitia grosvenori

<400>  12

Met Trp Arg Leu Lys Val Gly Ala Glu Ser Val Gly Glu Asn Asp Glu 
1               5                   10                  15      


Lys Trp Leu Lys Ser Ile Ser Asn His Leu Gly Arg Gln Val Trp Glu 
            20                  25                  30          


Phe Cys Pro Asp Ala Gly Thr Gln Gln Gln Leu Leu Gln Val His Lys 
        35                  40                  45              


Ala Arg Lys Ala Phe His Asp Asp Arg Phe His Arg Lys Gln Ser Ser 
    50                  55                  60                  


Asp Leu Phe Ile Thr Ile Gln Tyr Gly Lys Glu Val Glu Asn Gly Gly 
65                  70                  75                  80  


Lys Thr Ala Gly Val Lys Leu Lys Glu Gly Glu Glu Val Arg Lys Glu 
                85                  90                  95      


Ala Val Glu Ser Ser Leu Glu Arg Ala Leu Ser Phe Tyr Ser Ser Ile 
            100                 105                 110         


Gln Thr Ser Asp Gly Asn Trp Ala Ser Asp Leu Gly Gly Pro Met Phe 
        115                 120                 125             


Leu Leu Pro Gly Leu Val Ile Ala Leu Tyr Val Thr Gly Val Leu Asn 
    130                 135                 140                 


Ser Val Leu Ser Lys His His Arg Gln Glu Met Cys Arg Tyr Val Tyr 
145                 150                 155                 160 


Asn His Gln Asn Glu Asp Gly Gly Trp Gly Leu His Ile Glu Gly Pro 
                165                 170                 175     


Ser Thr Met Phe Gly Ser Ala Leu Asn Tyr Val Ala Leu Arg Leu Leu 
            180                 185                 190         


Gly Glu Asp Ala Asn Ala Gly Ala Met Pro Lys Ala Arg Ala Trp Ile 
        195                 200                 205             


Leu Asp His Gly Gly Ala Thr Gly Ile Thr Ser Trp Gly Lys Leu Trp 
    210                 215                 220                 


Leu Ser Val Leu Gly Val Tyr Glu Trp Ser Gly Asn Asn Pro Leu Pro 
225                 230                 235                 240 


Pro Glu Phe Trp Leu Phe Pro Tyr Phe Leu Pro Phe His Pro Gly Arg 
                245                 250                 255     


Met Trp Cys His Cys Arg Met Val Tyr Leu Pro Met Ser Tyr Leu Tyr 
            260                 265                 270         


Gly Lys Arg Phe Val Gly Pro Ile Thr Pro Ile Val Leu Ser Leu Arg 
        275                 280                 285             


Lys Glu Leu Tyr Ala Val Pro Tyr His Glu Ile Asp Trp Asn Lys Ser 
    290                 295                 300                 


Arg Asn Thr Cys Ala Lys Glu Asp Leu Tyr Tyr Pro His Pro Lys Met 
305                 310                 315                 320 


Gln Asp Ile Leu Trp Gly Ser Leu His His Val Tyr Glu Pro Leu Phe 
                325                 330                 335     


Thr Arg Trp Pro Ala Lys Arg Leu Arg Glu Lys Ala Leu Gln Thr Ala 
            340                 345                 350         


Met Gln His Ile His Tyr Glu Asp Glu Asn Thr Arg Tyr Ile Cys Leu 
        355                 360                 365             


Gly Pro Val Asn Lys Val Leu Asn Leu Leu Cys Cys Trp Val Glu Asp 
    370                 375                 380                 


Pro Tyr Ser Asp Ala Phe Lys Leu His Leu Gln Arg Val His Asp Tyr 
385                 390                 395                 400 


Leu Trp Val Ala Glu Asp Gly Met Lys Met Gln Gly Tyr Asn Gly Ser 
                405                 410                 415     


Gln Leu Trp Asp Thr Ala Phe Ser Ile Gln Ala Ile Val Ser Thr Lys 
            420                 425                 430         


Leu Val Asp Asn Tyr Gly Pro Thr Leu Arg Lys Ala His Asp Phe Val 
        435                 440                 445             


Lys Ser Ser Gln Ile Gln Gln Asp Cys Pro Gly Asp Pro Asn Val Trp 
    450                 455                 460                 


Tyr Arg His Ile His Lys Gly Ala Trp Pro Phe Ser Thr Arg Asp His 
465                 470                 475                 480 


Gly Trp Leu Ile Ser Asp Cys Thr Ala Glu Gly Leu Lys Ala Ala Leu 
                485                 490                 495     


Met Leu Ser Lys Leu Pro Ser Glu Thr Val Gly Glu Ser Leu Glu Arg 
            500                 505                 510         


Asn Arg Leu Cys Asp Ala Val Asn Val Leu Leu Ser Leu Gln Asn Asp 
        515                 520                 525             


Asn Gly Gly Phe Ala Ser Tyr Glu Leu Thr Arg Ser Tyr Pro Trp Leu 
    530                 535                 540                 


Glu Leu Ile Asn Pro Ala Glu Thr Phe Gly Asp Ile Val Ile Asp Tyr 
545                 550                 555                 560 


Pro Tyr Val Glu Cys Thr Ser Ala Thr Met Glu Ala Leu Thr Leu Phe 
                565                 570                 575     


Lys Lys Leu His Pro Gly His Arg Thr Lys Glu Ile Asp Thr Ala Ile 
            580                 585                 590         


Val Arg Ala Ala Asn Phe Leu Glu Asn Met Gln Arg Thr Asp Gly Ser 
        595                 600                 605             


Trp Tyr Gly Cys Trp Gly Val Cys Phe Thr Tyr Ala Gly Trp Phe Gly 
    610                 615                 620                 


Ile Lys Gly Leu Val Ala Ala Gly Arg Thr Tyr Asn Asn Cys Leu Ala 
625                 630                 635                 640 


Ile Arg Lys Ala Cys Asp Phe Leu Leu Ser Lys Glu Leu Pro Gly Gly 
                645                 650                 655     


Gly Trp Gly Glu Ser Tyr Leu Ser Cys Gln Asn Lys Val Tyr Thr Asn 
            660                 665                 670         


Leu Glu Gly Asn Arg Pro His Leu Val Asn Thr Ala Trp Val Leu Met 
        675                 680                 685             


Ala Leu Ile Glu Ala Gly Gln Ala Glu Arg Asp Pro Thr Pro Leu His 
    690                 695                 700                 


Arg Ala Ala Arg Leu Leu Ile Asn Ser Gln Leu Glu Asn Gly Asp Phe 
705                 710                 715                 720 


Pro Gln Gln Glu Ile Met Gly Val Phe Asn Lys Asn Cys Met Ile Thr 
                725                 730                 735     


Tyr Ala Ala Tyr Arg Asn Ile Phe Pro Ile Trp Ala Leu Gly Glu Tyr 
            740                 745                 750         


Cys His Arg Val Leu Thr Glu 
        755                 


<210>  13
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised Nucleic Acid sequence encoding squalene epoxidase

<400>  13
atggtcgatc agtgtgctct gggctggatc ctggcgtcag tgcttggtgc agctgcatta       60

tatttcctat ttggaagaaa aaacggggga gtttcaaacg aaagaagaca tgaatcaatt      120

aagaacattg caactacgaa tggtgaatac aagtcttcca actctgatgg tgatatcatt      180

atcgtgggcg ccggtgtagc aggatctgct ttggcatata cattagggaa agacggtcgt      240

agagttcatg tgatagagag agatcttacg gaaccggaca ggattgttgg tgaacttttg      300

cagccgggcg gatacttaaa actgacggaa ctaggtttag aggattgcgt tgatgacatt      360

gatgctcaaa gagtttacgg ctacgccttg ttcaaagacg gtaaagatac taggttaagt      420

tatcctctag aaaaatttca ttccgacgtt gctggcagat cctttcacaa cggaagattt      480

atacaaagaa tgagagaaaa agccgctagt ctaccaaatg tatccttgga acaaggtaca      540

gttacatcct tattagaaga gaatggtatt atcaaaggcg tgcaatataa aacgaaaacc      600

ggacaagaaa tgactgctta tgccccatta acaatcgtgt gtgatggctg cttctctaat      660

ttgagaagat ctctttgtaa tccaaaggtt gacgttccta gctgctttgt tggtttggtt      720

ttggaaaatt gcgatttacc gtatgctaac catggacatg ttatcctagc agatccgtct      780

ccaattctgt tctacagaat tagttcaact gaaattagat gtttggttga tgtccctggt      840

cagaaggttc caagtatctc caacggtgaa atggctaatt acctaaaaaa cgttgttgct      900

ccgcaaattc ccagccagtt gtacgactct ttcgttgccg cgatagacaa aggtaatatc      960

agaacgatgc cgaataggtc catgcctgct gacccatatc ccaccccagg agcgttattg     1020

atgggtgatg cttttaatat gagacatcca ttaacaggcg gagggatgac tgttgctttg     1080

tctgatgttg tcgtcttgag agatttatta aaaccgcttc gtgatctaaa cgatgcacct     1140

acattgtcaa agtatttaga ggccttttac acgttgagga agcctgttgc tagtaccatt     1200

aatacgttgg ctggagctct gtataaggtg ttttgcgcct caccagacca agctagaaaa     1260

gaaatgcgtc aagcttgttt cgactaccta agtctgggtg gtatatttag taacggtcct     1320

gtctctctat tgtcagggct aaacccacgt cctattagtc ttgtcttgca cttcttcgca     1380

gtggcgattt atggtgttgg taggttgctg attccgtttc ccagtcctaa acgtgtgtgg     1440

ataggtgcaa gaattatctc tggtgcgtca gcgattattt ttccaattat taaggctgaa     1500

ggtgtgagac aaatgttttt ccctgctact gttgccgcgt attacagagc accaagggtt     1560

gtcaagggca gataa                                                      1575


<210>  14
<211>  524
<212>  PRT
<213>  Siraitia grosvenori

<400>  14

Met Val Asp Gln Cys Ala Leu Gly Trp Ile Leu Ala Ser Val Leu Gly 
1               5                   10                  15      


Ala Ala Ala Leu Tyr Phe Leu Phe Gly Arg Lys Asn Gly Gly Val Ser 
            20                  25                  30          


Asn Glu Arg Arg His Glu Ser Ile Lys Asn Ile Ala Thr Thr Asn Gly 
        35                  40                  45              


Glu Tyr Lys Ser Ser Asn Ser Asp Gly Asp Ile Ile Ile Val Gly Ala 
    50                  55                  60                  


Gly Val Ala Gly Ser Ala Leu Ala Tyr Thr Leu Gly Lys Asp Gly Arg 
65                  70                  75                  80  


Arg Val His Val Ile Glu Arg Asp Leu Thr Glu Pro Asp Arg Ile Val 
                85                  90                  95      


Gly Glu Leu Leu Gln Pro Gly Gly Tyr Leu Lys Leu Thr Glu Leu Gly 
            100                 105                 110         


Leu Glu Asp Cys Val Asp Asp Ile Asp Ala Gln Arg Val Tyr Gly Tyr 
        115                 120                 125             


Ala Leu Phe Lys Asp Gly Lys Asp Thr Arg Leu Ser Tyr Pro Leu Glu 
    130                 135                 140                 


Lys Phe His Ser Asp Val Ala Gly Arg Ser Phe His Asn Gly Arg Phe 
145                 150                 155                 160 


Ile Gln Arg Met Arg Glu Lys Ala Ala Ser Leu Pro Asn Val Ser Leu 
                165                 170                 175     


Glu Gln Gly Thr Val Thr Ser Leu Leu Glu Glu Asn Gly Ile Ile Lys 
            180                 185                 190         


Gly Val Gln Tyr Lys Thr Lys Thr Gly Gln Glu Met Thr Ala Tyr Ala 
        195                 200                 205             


Pro Leu Thr Ile Val Cys Asp Gly Cys Phe Ser Asn Leu Arg Arg Ser 
    210                 215                 220                 


Leu Cys Asn Pro Lys Val Asp Val Pro Ser Cys Phe Val Gly Leu Val 
225                 230                 235                 240 


Leu Glu Asn Cys Asp Leu Pro Tyr Ala Asn His Gly His Val Ile Leu 
                245                 250                 255     


Ala Asp Pro Ser Pro Ile Leu Phe Tyr Arg Ile Ser Ser Thr Glu Ile 
            260                 265                 270         


Arg Cys Leu Val Asp Val Pro Gly Gln Lys Val Pro Ser Ile Ser Asn 
        275                 280                 285             


Gly Glu Met Ala Asn Tyr Leu Lys Asn Val Val Ala Pro Gln Ile Pro 
    290                 295                 300                 


Ser Gln Leu Tyr Asp Ser Phe Val Ala Ala Ile Asp Lys Gly Asn Ile 
305                 310                 315                 320 


Arg Thr Met Pro Asn Arg Ser Met Pro Ala Asp Pro Tyr Pro Thr Pro 
                325                 330                 335     


Gly Ala Leu Leu Met Gly Asp Ala Phe Asn Met Arg His Pro Leu Thr 
            340                 345                 350         


Gly Gly Gly Met Thr Val Ala Leu Ser Asp Val Val Val Leu Arg Asp 
        355                 360                 365             


Leu Leu Lys Pro Leu Arg Asp Leu Asn Asp Ala Pro Thr Leu Ser Lys 
    370                 375                 380                 


Tyr Leu Glu Ala Phe Tyr Thr Leu Arg Lys Pro Val Ala Ser Thr Ile 
385                 390                 395                 400 


Asn Thr Leu Ala Gly Ala Leu Tyr Lys Val Phe Cys Ala Ser Pro Asp 
                405                 410                 415     


Gln Ala Arg Lys Glu Met Arg Gln Ala Cys Phe Asp Tyr Leu Ser Leu 
            420                 425                 430         


Gly Gly Ile Phe Ser Asn Gly Pro Val Ser Leu Leu Ser Gly Leu Asn 
        435                 440                 445             


Pro Arg Pro Ile Ser Leu Val Leu His Phe Phe Ala Val Ala Ile Tyr 
    450                 455                 460                 


Gly Val Gly Arg Leu Leu Ile Pro Phe Pro Ser Pro Lys Arg Val Trp 
465                 470                 475                 480 


Ile Gly Ala Arg Ile Ile Ser Gly Ala Ser Ala Ile Ile Phe Pro Ile 
                485                 490                 495     


Ile Lys Ala Glu Gly Val Arg Gln Met Phe Phe Pro Ala Thr Val Ala 
            500                 505                 510         


Ala Tyr Tyr Arg Ala Pro Arg Val Val Lys Gly Arg 
        515                 520                 


<210>  15
<211>  1587
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised Nucleic Acid sequence encoding squalene epoxidase

<400>  15
atggttgatc aatgtgcctt aggttggatc ttagcttccg ctttgggttt agtcattgct       60

ttgtgtttct tcgttgcccc aagaagaaac catagaggtg tcgattccaa agaaagagat      120

gaatgtgtcc aatctgctgc tactaccaag ggtgaatgca gatttaacga cagagatgtc      180

gatgtcattg ttgttggtgc tggtgttgcc ggttctgctt tggctcacac tttgggtaag      240

gatggtagaa gagttcatgt tatcgaaaga gacttaaccg aaccagacag aattgttggt      300

gagttgttgc aaccaggtgg ttacttgaaa ttgattgagt tgggtttgca agactgtgtt      360

gaagagatcg acgctcaaag agtttacggt tatgctttat tcaaggacgg taagaatacc      420

cgtttatcct acccattgga aaatttccat tctgacgttt ctggtagatc tttccacaac      480

ggtagattta ttcaaagaat gagagaaaaa gccgcttctt taccaaacgt tagattggaa      540

caaggtactg ttacttcttt gttagaagaa aaaggtacca ttaaaggtgt tcaatacaag      600

tccaaaaacg gtgaagaaaa gaccgcttac gctcctttga ccatcgtttg tgacggttgt      660

ttttctaact tgagaagatc tttgtgtaac cctatggttg atgttccatc ttactttgtc      720

ggtttggttt tggaaaattg tgaattgcca tttgccaacc atggtcacgt tattttgggt      780

gacccttccc caattttgtt ctaccaaatt tcccgtactg aaatcagatg tttggtcgat      840

gttccaggtc aaaaagttcc ttctatcgcc aacggtgaaa tggagaagta tttaaagacc      900

gtcgttgctc cacaagtccc tccacaaatt tacgactcct tcatcgctgc tattgacaag      960

ggtaacatca gaactatgcc aaatagatcc atgccagctg ctccacaccc aaccccaggt     1020

gccttattaa tgggtgacgc ttttaacatg cgtcacccat tgaccggtgg tggtatgact     1080

gtcgctttgt ctgacattgt tgtcttgcgt aacttattga agccattgaa ggacttgtct     1140

gacgcctcta ccttgtgtaa gtacttggaa tccttctaca ctttgagaaa gccagttgct     1200

tccactatca acaccttggc tggtgccttg tacaaggttt tctgtgcttc tccagaccaa     1260

gctagaaaag aaatgagaca agcttgtttt gactacttat ctttgggtgg tattttctct     1320

aacggtccag tttccttgtt gtccggtttg aaccctagac cattgtcctt agttttgcac     1380

tttttcgccg tcgctatcta cggtgttggt agattgttgt tgccattccc ttctgtcaag     1440

ggtatctgga ttggtgctag attgatctac tctgcttctg gtattatctt cccaatcatt     1500

agagccgaag gtgtcagaca aatgttcttc ccagccactg ttcctgctta ctaccgttcc     1560

ccaccagttt tcaagccaat cgtttaa                                         1587


<210>  16
<211>  528
<212>  PRT
<213>  Siraitia grosvenori

<400>  16

Met Val Asp Gln Cys Ala Leu Gly Trp Ile Leu Ala Ser Ala Leu Gly 
1               5                   10                  15      


Leu Val Ile Ala Leu Cys Phe Phe Val Ala Pro Arg Arg Asn His Arg 
            20                  25                  30          


Gly Val Asp Ser Lys Glu Arg Asp Glu Cys Val Gln Ser Ala Ala Thr 
        35                  40                  45              


Thr Lys Gly Glu Cys Arg Phe Asn Asp Arg Asp Val Asp Val Ile Val 
    50                  55                  60                  


Val Gly Ala Gly Val Ala Gly Ser Ala Leu Ala His Thr Leu Gly Lys 
65                  70                  75                  80  


Asp Gly Arg Arg Val His Val Ile Glu Arg Asp Leu Thr Glu Pro Asp 
                85                  90                  95      


Arg Ile Val Gly Glu Leu Leu Gln Pro Gly Gly Tyr Leu Lys Leu Ile 
            100                 105                 110         


Glu Leu Gly Leu Gln Asp Cys Val Glu Glu Ile Asp Ala Gln Arg Val 
        115                 120                 125             


Tyr Gly Tyr Ala Leu Phe Lys Asp Gly Lys Asn Thr Arg Leu Ser Tyr 
    130                 135                 140                 


Pro Leu Glu Asn Phe His Ser Asp Val Ser Gly Arg Ser Phe His Asn 
145                 150                 155                 160 


Gly Arg Phe Ile Gln Arg Met Arg Glu Lys Ala Ala Ser Leu Pro Asn 
                165                 170                 175     


Val Arg Leu Glu Gln Gly Thr Val Thr Ser Leu Leu Glu Glu Lys Gly 
            180                 185                 190         


Thr Ile Lys Gly Val Gln Tyr Lys Ser Lys Asn Gly Glu Glu Lys Thr 
        195                 200                 205             


Ala Tyr Ala Pro Leu Thr Ile Val Cys Asp Gly Cys Phe Ser Asn Leu 
    210                 215                 220                 


Arg Arg Ser Leu Cys Asn Pro Met Val Asp Val Pro Ser Tyr Phe Val 
225                 230                 235                 240 


Gly Leu Val Leu Glu Asn Cys Glu Leu Pro Phe Ala Asn His Gly His 
                245                 250                 255     


Val Ile Leu Gly Asp Pro Ser Pro Ile Leu Phe Tyr Gln Ile Ser Arg 
            260                 265                 270         


Thr Glu Ile Arg Cys Leu Val Asp Val Pro Gly Gln Lys Val Pro Ser 
        275                 280                 285             


Ile Ala Asn Gly Glu Met Glu Lys Tyr Leu Lys Thr Val Val Ala Pro 
    290                 295                 300                 


Gln Val Pro Pro Gln Ile Tyr Asp Ser Phe Ile Ala Ala Ile Asp Lys 
305                 310                 315                 320 


Gly Asn Ile Arg Thr Met Pro Asn Arg Ser Met Pro Ala Ala Pro His 
                325                 330                 335     


Pro Thr Pro Gly Ala Leu Leu Met Gly Asp Ala Phe Asn Met Arg His 
            340                 345                 350         


Pro Leu Thr Gly Gly Gly Met Thr Val Ala Leu Ser Asp Ile Val Val 
        355                 360                 365             


Leu Arg Asn Leu Leu Lys Pro Leu Lys Asp Leu Ser Asp Ala Ser Thr 
    370                 375                 380                 


Leu Cys Lys Tyr Leu Glu Ser Phe Tyr Thr Leu Arg Lys Pro Val Ala 
385                 390                 395                 400 


Ser Thr Ile Asn Thr Leu Ala Gly Ala Leu Tyr Lys Val Phe Cys Ala 
                405                 410                 415     


Ser Pro Asp Gln Ala Arg Lys Glu Met Arg Gln Ala Cys Phe Asp Tyr 
            420                 425                 430         


Leu Ser Leu Gly Gly Ile Phe Ser Asn Gly Pro Val Ser Leu Leu Ser 
        435                 440                 445             


Gly Leu Asn Pro Arg Pro Leu Ser Leu Val Leu His Phe Phe Ala Val 
    450                 455                 460                 


Ala Ile Tyr Gly Val Gly Arg Leu Leu Leu Pro Phe Pro Ser Val Lys 
465                 470                 475                 480 


Gly Ile Trp Ile Gly Ala Arg Leu Ile Tyr Ser Ala Ser Gly Ile Ile 
                485                 490                 495     


Phe Pro Ile Ile Arg Ala Glu Gly Val Arg Gln Met Phe Phe Pro Ala 
            500                 505                 510         


Thr Val Pro Ala Tyr Tyr Arg Ser Pro Pro Val Phe Lys Pro Ile Val 
        515                 520                 525             


<210>  17
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised Nucleic Acid sequence encoding epoxy hydratase

<400>  17
atggaaaaca tcgaacacac cactgtccaa actaacggta tcaagatgca cgtcgctgct       60

attggtactg gtccaccagt tttgttgttg catggtttcc cagaattgtg gtattcttgg      120

agacaccaat tgttgtactt gtcttctgct ggttacagag ctatcgctcc agacttgaga      180

ggttacggtg ataccgacgc tccaccttcc ccatcttcct ataccgcttt acacattgtc      240

ggtgatttgg tcggtttgtt ggacgtcttg ggtatcgaaa aagtcttctt aatcggtcac      300

gactggggtg ccatcatcgc ctggtacttc tgtttattca gacctgatag aatcaaagct      360

ttggttaact tgtctgttca attcttccca agaaacccaa ccaccccatt tgttaagggt      420

ttcagagccg tcttgggtga tcaattttac atggttagat tccaagaacc aggtaaagct      480

gaagaagaat tcgcttccgt tgatattaga gaattcttca agaatgtttt gtccaacaga      540

gatccacaag ctccatattt gccaaatgaa gttaagttcg aaggtgtccc accaccagct      600

ttggctccat ggttgacccc agaagatatc gatgtctacg ctgacaaatt cgctgaaact      660

ggtttcactg gtggtttgaa ctactacaga gcctttgaca gaacctggga attaactgct      720

ccatggaccg gtgcccgtat tggtgtccca gtcaagttca ttgtcggtga tttggacttg      780

acttaccact ttccaggtgc tcaaaaatac attcacggtg aaggtttcaa gaaggctgtc      840

ccaggtttgg aagaagttgt cgttatggag gatacctctc acttcattaa ccaagaaaga      900

ccacacgaaa ttaattctca catccacgat ttcttctcta agttctgtta a               951


<210>  18
<211>  316
<212>  PRT
<213>  Siraitia grosvenori

<400>  18

Met Glu Asn Ile Glu His Thr Thr Val Gln Thr Asn Gly Ile Lys Met 
1               5                   10                  15      


His Val Ala Ala Ile Gly Thr Gly Pro Pro Val Leu Leu Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Leu Leu Tyr Leu Ser 
        35                  40                  45              


Ser Ala Gly Tyr Arg Ala Ile Ala Pro Asp Leu Arg Gly Tyr Gly Asp 
    50                  55                  60                  


Thr Asp Ala Pro Pro Ser Pro Ser Ser Tyr Thr Ala Leu His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Val Gly Leu Leu Asp Val Leu Gly Ile Glu Lys Val Phe 
                85                  90                  95      


Leu Ile Gly His Asp Trp Gly Ala Ile Ile Ala Trp Tyr Phe Cys Leu 
            100                 105                 110         


Phe Arg Pro Asp Arg Ile Lys Ala Leu Val Asn Leu Ser Val Gln Phe 
        115                 120                 125             


Phe Pro Arg Asn Pro Thr Thr Pro Phe Val Lys Gly Phe Arg Ala Val 
    130                 135                 140                 


Leu Gly Asp Gln Phe Tyr Met Val Arg Phe Gln Glu Pro Gly Lys Ala 
145                 150                 155                 160 


Glu Glu Glu Phe Ala Ser Val Asp Ile Arg Glu Phe Phe Lys Asn Val 
                165                 170                 175     


Leu Ser Asn Arg Asp Pro Gln Ala Pro Tyr Leu Pro Asn Glu Val Lys 
            180                 185                 190         


Phe Glu Gly Val Pro Pro Pro Ala Leu Ala Pro Trp Leu Thr Pro Glu 
        195                 200                 205             


Asp Ile Asp Val Tyr Ala Asp Lys Phe Ala Glu Thr Gly Phe Thr Gly 
    210                 215                 220                 


Gly Leu Asn Tyr Tyr Arg Ala Phe Asp Arg Thr Trp Glu Leu Thr Ala 
225                 230                 235                 240 


Pro Trp Thr Gly Ala Arg Ile Gly Val Pro Val Lys Phe Ile Val Gly 
                245                 250                 255     


Asp Leu Asp Leu Thr Tyr His Phe Pro Gly Ala Gln Lys Tyr Ile His 
            260                 265                 270         


Gly Glu Gly Phe Lys Lys Ala Val Pro Gly Leu Glu Glu Val Val Val 
        275                 280                 285             


Met Glu Asp Thr Ser His Phe Ile Asn Gln Glu Arg Pro His Glu Ile 
    290                 295                 300                 


Asn Ser His Ile His Asp Phe Phe Ser Lys Phe Cys 
305                 310                 315     


<210>  19
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised Nucleic Acid sequence encoding epoxy hydratase

<400>  19
atggatcaaa ttgaacacat cactattaac accaacggta tcaaaatgca tatcgcctct       60

gttggtactg gtcctgttgt tttgttgttg catggtttcc cagaattgtg gtactcttgg      120

cgtcatcaat tgttgtattt gtcctctgtc ggttacagag ctattgctcc agatttaaga      180

ggttacggtg atactgactc tccagcctct ccaacttctt ataccgcttt gcatatcgtt      240

ggtgacttgg tcggtgcttt ggatgaattg ggtattgaaa aggtcttctt ggtcggtcat      300

gattgggctg ccatcatcgc ttggtacttt tgtttgttta gaccagatcg tattaaagct      360

ttagttaatt tgtctgttca attcatccca agaaacccag ctatcccatt tattgaaggt      420

ttcagaaccg cttttggtga tgatttctac atgtgtagat tccaagttcc aggtgaagct      480

gaagaagact ttgcttctat tgatactgct caattgttca aaacctcctt gtgtaacaga      540

tcctccgctc caccatgctt gccaaaagaa atcggtttca gagctattcc accaccagaa      600

aatttgccat cttggttgac cgaggaagac attaattact acgctgctaa gttcaagcaa      660

accggtttca ctggtgcttt aaactactat agagctttcg atttgacctg ggaattaact      720

gctccatgga ccggtgctca aattcaagtc ccagtcaagt tcattgttgg tgattctgac      780

ttgacttacc attttccagg tgctaaggaa tacatccaca acggtggttt caagaaggac      840

gttccattgt tggaagaagt tgttgttgtc aaggacgctt gtcacttcat caaccaagaa      900

agaccacaag aaattaacgc tcacattcat gactttatta acaagttcta a               951


<210>  20
<211>  316
<212>  PRT
<213>  Siraitia grosvenori

<400>  20

Met Asp Gln Ile Glu His Ile Thr Ile Asn Thr Asn Gly Ile Lys Met 
1               5                   10                  15      


His Ile Ala Ser Val Gly Thr Gly Pro Val Val Leu Leu Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Leu Leu Tyr Leu Ser 
        35                  40                  45              


Ser Val Gly Tyr Arg Ala Ile Ala Pro Asp Leu Arg Gly Tyr Gly Asp 
    50                  55                  60                  


Thr Asp Ser Pro Ala Ser Pro Thr Ser Tyr Thr Ala Leu His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Val Gly Ala Leu Asp Glu Leu Gly Ile Glu Lys Val Phe 
                85                  90                  95      


Leu Val Gly His Asp Trp Ala Ala Ile Ile Ala Trp Tyr Phe Cys Leu 
            100                 105                 110         


Phe Arg Pro Asp Arg Ile Lys Ala Leu Val Asn Leu Ser Val Gln Phe 
        115                 120                 125             


Ile Pro Arg Asn Pro Ala Ile Pro Phe Ile Glu Gly Phe Arg Thr Ala 
    130                 135                 140                 


Phe Gly Asp Asp Phe Tyr Met Cys Arg Phe Gln Val Pro Gly Glu Ala 
145                 150                 155                 160 


Glu Glu Asp Phe Ala Ser Ile Asp Thr Ala Gln Leu Phe Lys Thr Ser 
                165                 170                 175     


Leu Cys Asn Arg Ser Ser Ala Pro Pro Cys Leu Pro Lys Glu Ile Gly 
            180                 185                 190         


Phe Arg Ala Ile Pro Pro Pro Glu Asn Leu Pro Ser Trp Leu Thr Glu 
        195                 200                 205             


Glu Asp Ile Asn Tyr Tyr Ala Ala Lys Phe Lys Gln Thr Gly Phe Thr 
    210                 215                 220                 


Gly Ala Leu Asn Tyr Tyr Arg Ala Phe Asp Leu Thr Trp Glu Leu Thr 
225                 230                 235                 240 


Ala Pro Trp Thr Gly Ala Gln Ile Gln Val Pro Val Lys Phe Ile Val 
                245                 250                 255     


Gly Asp Ser Asp Leu Thr Tyr His Phe Pro Gly Ala Lys Glu Tyr Ile 
            260                 265                 270         


His Asn Gly Gly Phe Lys Lys Asp Val Pro Leu Leu Glu Glu Val Val 
        275                 280                 285             


Val Val Lys Asp Ala Cys His Phe Ile Asn Gln Glu Arg Pro Gln Glu 
    290                 295                 300                 


Ile Asn Ala His Ile His Asp Phe Ile Asn Lys Phe 
305                 310                 315     


<210>  21
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised Nucleic Acid sequence encoding epoxy hydratase

<400>  21
atggagaaga ttgaacactc tactatcgct actaatggta tcaatatgca cgttgcctct       60

gctggttctg gtccagctgt tttgtttttg cacggtttcc cagaattatg gtattcctgg      120

agacaccaat tgttgtactt gtcttctttg ggttacagag ctattgctcc agatttgaga      180

ggtttcggtg acaccgatgc tccaccatct ccatcctcct acaccgccca ccacatcgtt      240

ggtgatttgg tcggtttgtt ggatcaatta ggtgtcgatc aagtcttttt ggttggtcat      300

gattggggtg ctatgatggc ctggtacttc tgtttgttcc gtccagacag agtcaaggcc      360

ttagttaatt tatctgtcca cttcacccca cgtaacccag ctatctctcc attagatggt      420

ttccgtttga tgttgggtga tgatttctac gtttgtaagt ttcaagaacc aggtgtcgct      480

gaagccgatt tcggttctgt tgatactgcc actatgttta aaaagttctt gaccatgaga      540

gatccacgtc cacctattat tccaaacggt ttcagatcct tggccacccc agaagctttg      600

ccatcctggt tgactgaaga ggatatcgat tactttgctg ccaaattcgc taagactggt      660

tttactggtg gtttcaacta ctacagagct atcgacttga cctgggagtt gactgctcca      720

tggtccggtt ctgaaatcaa ggttccaact aagtttattg ttggtgactt agacttggtt      780

taccatttcc caggtgttaa ggaatacatt cacggtggtg gtttcaagaa ggacgttcca      840

ttcttggaag aagttgtcgt catggaaggt gctgctcatt ttatcaacca agaaaaagct      900

gacgaaatta attctttgat ctatgacttc attaaacaat tctag                      945


<210>  22
<211>  314
<212>  PRT
<213>  Siraitia grosvenori

<400>  22

Met Glu Lys Ile Glu His Ser Thr Ile Ala Thr Asn Gly Ile Asn Met 
1               5                   10                  15      


His Val Ala Ser Ala Gly Ser Gly Pro Ala Val Leu Phe Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Leu Leu Tyr Leu Ser 
        35                  40                  45              


Ser Leu Gly Tyr Arg Ala Ile Ala Pro Asp Leu Arg Gly Phe Gly Asp 
    50                  55                  60                  


Thr Asp Ala Pro Pro Ser Pro Ser Ser Tyr Thr Ala His His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Val Gly Leu Leu Asp Gln Leu Gly Val Asp Gln Val Phe 
                85                  90                  95      


Leu Val Gly His Asp Trp Gly Ala Met Met Ala Trp Tyr Phe Cys Leu 
            100                 105                 110         


Phe Arg Pro Asp Arg Val Lys Ala Leu Val Asn Leu Ser Val His Phe 
        115                 120                 125             


Thr Pro Arg Asn Pro Ala Ile Ser Pro Leu Asp Gly Phe Arg Leu Met 
    130                 135                 140                 


Leu Gly Asp Asp Phe Tyr Val Cys Lys Phe Gln Glu Pro Gly Val Ala 
145                 150                 155                 160 


Glu Ala Asp Phe Gly Ser Val Asp Thr Ala Thr Met Phe Lys Lys Phe 
                165                 170                 175     


Leu Thr Met Arg Asp Pro Arg Pro Pro Ile Ile Pro Asn Gly Phe Arg 
            180                 185                 190         


Ser Leu Ala Thr Pro Glu Ala Leu Pro Ser Trp Leu Thr Glu Glu Asp 
        195                 200                 205             


Ile Asp Tyr Phe Ala Ala Lys Phe Ala Lys Thr Gly Phe Thr Gly Gly 
    210                 215                 220                 


Phe Asn Tyr Tyr Arg Ala Ile Asp Leu Thr Trp Glu Leu Thr Ala Pro 
225                 230                 235                 240 


Trp Ser Gly Ser Glu Ile Lys Val Pro Thr Lys Phe Ile Val Gly Asp 
                245                 250                 255     


Leu Asp Leu Val Tyr His Phe Pro Gly Val Lys Glu Tyr Ile His Gly 
            260                 265                 270         


Gly Gly Phe Lys Lys Asp Val Pro Phe Leu Glu Glu Val Val Val Met 
        275                 280                 285             


Glu Gly Ala Ala His Phe Ile Asn Gln Glu Lys Ala Asp Glu Ile Asn 
    290                 295                 300                 


Ser Leu Ile Tyr Asp Phe Ile Lys Gln Phe 
305                 310                 


<210>  23
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised Nucleic Acid sequence encoding epoxy hydratase

<400>  23
atggaaaaga ttgaacacac cactatttct accaatggta tcaacatgca tgttgcctct       60

attggttctg gtccagctgt cttgttcttg cacggtttcc cagaattgtg gtattcttgg      120

agacaccaat tattattctt gtcttccatg ggttacagag ctatcgctcc agacttaaga      180

ggttttggtg acaccgacgc tccaccatct ccatcttctt acaccgctca ccacattgtc      240

ggtgacttgg tcggtttgtt agaccaattg ggtattgacc aagttttttt ggttggtcac      300

gactggggtg ctatgatggc ctggtacttt tgtttgttcc gtccagatag agttaaggct      360

ttggtcaatt tatctgtcca cttcttacgt agacacccat ctatcaaatt tgttgatggt      420

ttcagagcct tattaggtga tgatttttac ttctgtcaat tccaagaacc aggtgtcgct      480

gaagccgact tcggttctgt cgatgttgct accatgttga agaaattctt gaccatgaga      540

gatccaagac ctccaatgat tcctaaggaa aagggtttca gagccttgga aactccagat      600

ccattgccag cctggttaac tgaagaagac attgactact tcgccggtaa gtttcgtaag      660

accggtttta ccggtggttt taattactac agagccttca acttgacttg ggagttgacc      720

gctccatggt ctggttctga aatcaaggtc gctgccaagt tcattgttgg tgatttagac      780

ttggtttatc acttccctgg tgccaaggag tatatccatg gtggtggttt caaaaaggac      840

gtccctttgt tggaggaagt tgttgttgtt gatggtgctg ctcacttcat caaccaagaa      900

agaccagctg aaatttcttc cttgatttac gactttatca agaagttcta a               951


<210>  24
<211>  316
<212>  PRT
<213>  Siraitia grosvenori

<400>  24

Met Glu Lys Ile Glu His Thr Thr Ile Ser Thr Asn Gly Ile Asn Met 
1               5                   10                  15      


His Val Ala Ser Ile Gly Ser Gly Pro Ala Val Leu Phe Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Leu Leu Phe Leu Ser 
        35                  40                  45              


Ser Met Gly Tyr Arg Ala Ile Ala Pro Asp Leu Arg Gly Phe Gly Asp 
    50                  55                  60                  


Thr Asp Ala Pro Pro Ser Pro Ser Ser Tyr Thr Ala His His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Val Gly Leu Leu Asp Gln Leu Gly Ile Asp Gln Val Phe 
                85                  90                  95      


Leu Val Gly His Asp Trp Gly Ala Met Met Ala Trp Tyr Phe Cys Leu 
            100                 105                 110         


Phe Arg Pro Asp Arg Val Lys Ala Leu Val Asn Leu Ser Val His Phe 
        115                 120                 125             


Leu Arg Arg His Pro Ser Ile Lys Phe Val Asp Gly Phe Arg Ala Leu 
    130                 135                 140                 


Leu Gly Asp Asp Phe Tyr Phe Cys Gln Phe Gln Glu Pro Gly Val Ala 
145                 150                 155                 160 


Glu Ala Asp Phe Gly Ser Val Asp Val Ala Thr Met Leu Lys Lys Phe 
                165                 170                 175     


Leu Thr Met Arg Asp Pro Arg Pro Pro Met Ile Pro Lys Glu Lys Gly 
            180                 185                 190         


Phe Arg Ala Leu Glu Thr Pro Asp Pro Leu Pro Ala Trp Leu Thr Glu 
        195                 200                 205             


Glu Asp Ile Asp Tyr Phe Ala Gly Lys Phe Arg Lys Thr Gly Phe Thr 
    210                 215                 220                 


Gly Gly Phe Asn Tyr Tyr Arg Ala Phe Asn Leu Thr Trp Glu Leu Thr 
225                 230                 235                 240 


Ala Pro Trp Ser Gly Ser Glu Ile Lys Val Ala Ala Lys Phe Ile Val 
                245                 250                 255     


Gly Asp Leu Asp Leu Val Tyr His Phe Pro Gly Ala Lys Glu Tyr Ile 
            260                 265                 270         


His Gly Gly Gly Phe Lys Lys Asp Val Pro Leu Leu Glu Glu Val Val 
        275                 280                 285             


Val Val Asp Gly Ala Ala His Phe Ile Asn Gln Glu Arg Pro Ala Glu 
    290                 295                 300                 


Ile Ser Ser Leu Ile Tyr Asp Phe Ile Lys Lys Phe 
305                 310                 315     


<210>  25
<211>  1599
<212>  DNA
<213>  Siraitia grosvenori

<400>  25
atgctgatgc acgctctcac ccctacagct cctttcttct ctataaaacc taacacagaa       60

cccccttctg ctaccacacg gcagccaccc atggattccc caccccaaaa acctcacttc      120

cttctcttcc ctttcatggc tcagggccac atgatcccca tgattgacct tgccaagctt      180

ctggcccagc gaggagccat tattactgtc gtcaccacgc cccacaatgc tgctcgctac      240

cactctgttc tcgctcgcgc cattgattct gggttacaca tccatgtcct ccaacttcag      300

tttccatgca acgaaggcgg gttgccagaa gggtgcgaga atttcgactt gttaccttca      360

cttggttctg cctccacatt cttcagagca acattcctcc tttacgaacc atcggaaaaa      420

gtgttcgagg aactcatccc ccgccccacc tgcataatct ccgatatgtg tctgccctgg      480

accgtacgac ttgctcagaa atatcacgtc ccaaggctcg ttttctacag tttgagctgc      540

ttctttcttc tctgtatgcg gagtttaaaa aacaatcaag ctcttataag ctccaagtct      600

gattctgagt tggtaacttt ctcagacttg cctgatccag tcgagtttct caagtcgcag      660

ctgcctaaat ccaacgatga agaaatggca aagtttggtt atgaaatagg ggaggccgat      720

cggcaatcac acggcgttat tgtgaatgta tttgaggaga tggagccgaa gtatcttgcg      780

gagtatagaa aggaaagaga atcgccggaa aaagtgtggt gcgtcggccc agtttcgctt      840

tgcaacgaca acaaactcga caaggctcag agaggcaaca aagcctccat cgacgaacgc      900

gaatgcatcg agtggctcga cgggcagcag ccgtcttcag tggtttacgt gtctttagga      960

agtctgtgca atttggtgac ggcgcaactt attgagctgg gtttgggttt ggaggcatca     1020

aacaaaccat tcatttgggt catacgaaaa ggaaacataa cagaggagtt acagaaatgg     1080

ctggtggagt atgatttcga ggagaaaact aaagggagag ggctcgtgat tcttggctgg     1140

gctccccaag ttctgatact atcgcaccct gcaatcggat gctttttgac gcactgcggt     1200

tggaactcaa gcatcgaagg aatatcggcc ggcatgccca tgatcacttg gccacttttt     1260

gccgatcaag tcttcaacga gaagctaatc gtagagatac tcagaatcgg tgtaagtgtg     1320

ggcatggaaa cagctatgca ctggggagag gaagaggaga aaggggtggt ggtaaagaga     1380

gagaaagtga gagaagccat agaaagggcg atggatggag atgagagaga agagaggagg     1440

gagagatgca aagagcttgc tgaaatggcg aagagagccg tagaagaagg ggggtcgtct     1500

catcggaacc tgacgctgct aactgaagat attcttgtta atggaggagg tcaagagaga     1560

atggatgatg ctgatgattt tcctactata gttaattga                            1599


<210>  26
<211>  502
<212>  PRT
<213>  Siraitia grosvenori

<400>  26

Met Asp Ser Pro Pro Gln Lys Pro His Phe Leu Leu Phe Pro Phe Met 
1               5                   10                  15      


Ala Gln Gly His Met Ile Pro Met Ile Asp Leu Ala Lys Leu Leu Ala 
            20                  25                  30          


Gln Arg Gly Ala Ile Ile Thr Val Val Thr Thr Pro His Asn Ala Ala 
        35                  40                  45              


Arg Tyr His Ser Val Leu Ala Arg Ala Ile Asp Ser Gly Leu His Ile 
    50                  55                  60                  


His Val Leu Gln Leu Gln Phe Pro Cys Asn Glu Gly Gly Leu Pro Glu 
65                  70                  75                  80  


Gly Cys Glu Asn Phe Asp Leu Leu Pro Ser Leu Gly Ser Ala Ser Thr 
                85                  90                  95      


Phe Phe Arg Ala Thr Phe Leu Leu Tyr Glu Pro Ser Glu Lys Val Phe 
            100                 105                 110         


Glu Glu Leu Ile Pro Arg Pro Thr Cys Ile Ile Ser Asp Met Cys Leu 
        115                 120                 125             


Pro Trp Thr Val Arg Leu Ala Gln Lys Tyr His Val Pro Arg Leu Val 
    130                 135                 140                 


Phe Tyr Ser Leu Ser Cys Phe Phe Leu Leu Cys Met Arg Ser Leu Lys 
145                 150                 155                 160 


Asn Asn Gln Ala Leu Ile Ser Ser Lys Ser Asp Ser Glu Leu Val Thr 
                165                 170                 175     


Phe Ser Asp Leu Pro Asp Pro Val Glu Phe Leu Lys Ser Gln Leu Pro 
            180                 185                 190         


Lys Ser Asn Asp Glu Glu Met Ala Lys Phe Gly Tyr Glu Ile Gly Glu 
        195                 200                 205             


Ala Asp Arg Gln Ser His Gly Val Ile Val Asn Val Phe Glu Glu Met 
    210                 215                 220                 


Glu Pro Lys Tyr Leu Ala Glu Tyr Arg Lys Glu Arg Glu Ser Pro Glu 
225                 230                 235                 240 


Lys Val Trp Cys Val Gly Pro Val Ser Leu Cys Asn Asp Asn Lys Leu 
                245                 250                 255     


Asp Lys Ala Gln Arg Gly Asn Lys Ala Ser Ile Asp Glu Arg Glu Cys 
            260                 265                 270         


Ile Glu Trp Leu Asp Gly Gln Gln Pro Ser Ser Val Val Tyr Val Ser 
        275                 280                 285             


Leu Gly Ser Leu Cys Asn Leu Val Thr Ala Gln Leu Ile Glu Leu Gly 
    290                 295                 300                 


Leu Gly Leu Glu Ala Ser Asn Lys Pro Phe Ile Trp Val Ile Arg Lys 
305                 310                 315                 320 


Gly Asn Ile Thr Glu Glu Leu Gln Lys Trp Leu Val Glu Tyr Asp Phe 
                325                 330                 335     


Glu Glu Lys Thr Lys Gly Arg Gly Leu Val Ile Leu Gly Trp Ala Pro 
            340                 345                 350         


Gln Val Leu Ile Leu Ser His Pro Ala Ile Gly Cys Phe Leu Thr His 
        355                 360                 365             


Cys Gly Trp Asn Ser Ser Ile Glu Gly Ile Ser Ala Gly Met Pro Met 
    370                 375                 380                 


Ile Thr Trp Pro Leu Phe Ala Asp Gln Val Phe Asn Glu Lys Leu Ile 
385                 390                 395                 400 


Val Glu Ile Leu Arg Ile Gly Val Ser Val Gly Met Glu Thr Ala Met 
                405                 410                 415     


His Trp Gly Glu Glu Glu Glu Lys Gly Val Val Val Lys Arg Glu Lys 
            420                 425                 430         


Val Arg Glu Ala Ile Glu Arg Ala Met Asp Gly Asp Glu Arg Glu Glu 
        435                 440                 445             


Arg Arg Glu Arg Cys Lys Glu Leu Ala Glu Met Ala Lys Arg Ala Val 
    450                 455                 460                 


Glu Glu Gly Gly Ser Ser His Arg Asn Leu Thr Leu Leu Thr Glu Asp 
465                 470                 475                 480 


Ile Leu Val Asn Gly Gly Gly Gln Glu Arg Met Asp Asp Ala Asp Asp 
                485                 490                 495     


Phe Pro Thr Ile Val Asn 
            500         


<210>  27
<211>  1575
<212>  DNA
<213>  Siraitia grosvenori

<400>  27
atggagaaac tgcaggagaa gcttcggaaa ataaaacgtg ctgtccacgg ggctggcact       60

ctccaaagac caaaatgcta ttgtcaagtc aagctcttcc catctcccca agcaattaaa      120

agagaaagac ctcactttct gctcttccct ttcatggctc agggccacat gatccccatg      180

attgacctcg ccaagcttct ggctcagcga ggagccattg tcactatcct caccacgccc      240

cacaatgctg ctcgcaccca ctcagttctt gctcgcgcca tcgattctgg gttacaaatc      300

cgtgtccgcc cacttcagtt tccatgcaaa gaagccggcc tgccagaagg gtgcgagaat      360

ctcgacttgt taccttcact tggttctgcc tccacattct tcagagcaac atgtctcctt      420

tacgacccat cggaaaaact gttcgaggaa ctcagccccc ggccgacttg cataatctcc      480

gatatgtgtc tgccctggac catacgactt gctcagaaat atcacgtacc aaggctcgtt      540

ttctacagtt tgagctgctt ctttcttctc tgtatgcgga gtttaaaaaa caatccagcg      600

cttattagct ccaagtctga ttctgagttc gtaactttct ctgacttgcc tgatccagtc      660

gagtttctca agtcggagct acctaaatcc accgatgaag acttggtgaa gtttagttat      720

gaaatggggg aggccgatcg gaagtcatac ggcgttattt taaatatatt tgaggagatg      780

gaaccaaagt atcttgcgga atatggaaac gaaagagaat cgccggaaaa agtctggtgc      840

gtcggcccag tttcgctttg caacgacaac aaactcgaca aggctcagag aggcaacaaa      900

gcctccatcg acgaacgtga atgcatcaag tggctcggcg ggcagcagcc gtcttcagtg      960

gtttacgcgt ctttaggaag cttatgcaat ctggttacgg cgcaattcat agagttgggt     1020

ttgggtttgg aggcatcaaa taaaccattt atttgggtca ttagaaaagg aaacataaca     1080

gaagagctac aaaaatggct tgtggagtat gatttcgagg agaaaactaa agggagaggg     1140

ctggtgattc ttggctgggc tccccaagtt ctgatactgt cccacccttc aatcggatgc     1200

tttttgacgc actgtggttg gaactcaagc atcgaaggga tatcggccgg cgtgccaatg     1260

gtcacctggc cgcttttttc ggatcaagtc ttcaacgaga agctaattgt acaaatactc     1320

agaatcggcg taagtgtagg cgcggaaact gctatgaact ggggagagga agaggagaaa     1380

ggggtagtag tgaagagaga gaaagtgagg gaagccatag aaaggatgat ggatggagat     1440

gagagagaag agaggagaga gagatgcaaa gagcttgctg agacggcgaa gagagctata     1500

gaagaagggg gctcgtctca ccggaacctc acgctgttga ttgaagatat aggtacttca     1560

ttgaggaggt tgtga                                                      1575


<210>  28
<211>  488
<212>  PRT
<213>  Siraitia grosvenori

<400>  28

Met Asp Ser Pro Pro His Arg Pro His Phe Leu Leu Phe Pro Phe Met 
1               5                   10                  15      


Ala Gln Gly His Met Ile Pro Met Ile Asp Leu Ala Lys Leu Leu Ala 
            20                  25                  30          


Gln Arg Gly Ala Ile Val Thr Ile Leu Thr Thr Pro His Asn Ala Ala 
        35                  40                  45              


Arg Thr His Ser Val Leu Ala Arg Ala Ile Asp Ser Gly Leu Gln Ile 
    50                  55                  60                  


Arg Val Arg Pro Leu Gln Phe Pro Cys Lys Glu Ala Gly Leu Pro Glu 
65                  70                  75                  80  


Gly Cys Glu Asn Leu Asp Leu Leu Pro Ser Leu Gly Ser Ala Ser Thr 
                85                  90                  95      


Phe Phe Arg Ala Thr Cys Leu Leu Tyr Asp Pro Ser Glu Lys Leu Phe 
            100                 105                 110         


Glu Glu Leu Ser Pro Arg Pro Thr Cys Ile Ile Ser Asp Met Cys Leu 
        115                 120                 125             


Pro Trp Thr Ile Arg Leu Ala Gln Lys Tyr His Val Pro Arg Leu Val 
    130                 135                 140                 


Phe Tyr Ser Leu Ser Cys Phe Phe Leu Leu Cys Met Arg Ser Leu Lys 
145                 150                 155                 160 


Asn Asn Pro Ala Leu Ile Ser Ser Lys Ser Asp Ser Glu Phe Val Thr 
                165                 170                 175     


Phe Ser Asp Leu Pro Asp Pro Val Glu Phe Leu Lys Ser Glu Leu Pro 
            180                 185                 190         


Lys Ser Thr Asp Glu Asp Leu Val Lys Phe Ser Tyr Glu Met Gly Glu 
        195                 200                 205             


Ala Asp Arg Lys Ser Tyr Gly Val Ile Leu Asn Ile Phe Glu Glu Met 
    210                 215                 220                 


Glu Pro Lys Tyr Leu Ala Glu Tyr Gly Asn Glu Arg Glu Ser Pro Glu 
225                 230                 235                 240 


Lys Val Trp Cys Val Gly Pro Val Ser Leu Cys Asn Asp Asn Lys Leu 
                245                 250                 255     


Asp Lys Ala Gln Arg Gly Asn Lys Ala Ser Ile Asp Glu Arg Glu Cys 
            260                 265                 270         


Ile Lys Trp Leu Gly Gly Gln Gln Pro Ser Ser Val Val Tyr Ala Ser 
        275                 280                 285             


Leu Gly Ser Leu Cys Asn Leu Val Thr Ala Gln Phe Ile Glu Leu Gly 
    290                 295                 300                 


Leu Gly Leu Glu Ala Ser Asn Lys Pro Phe Ile Trp Val Ile Arg Lys 
305                 310                 315                 320 


Gly Asn Ile Thr Glu Glu Leu Gln Lys Trp Leu Val Glu Tyr Asp Phe 
                325                 330                 335     


Glu Glu Lys Thr Lys Gly Arg Gly Leu Val Ile Leu Gly Trp Ala Pro 
            340                 345                 350         


Gln Val Leu Ile Leu Ser His Pro Ser Ile Gly Cys Phe Leu Thr His 
        355                 360                 365             


Cys Gly Trp Asn Ser Ser Ile Glu Gly Ile Ser Ala Gly Val Pro Met 
    370                 375                 380                 


Val Thr Trp Pro Leu Phe Ser Asp Gln Val Phe Asn Glu Lys Leu Ile 
385                 390                 395                 400 


Val Gln Ile Leu Arg Ile Gly Val Ser Val Gly Ala Glu Thr Ala Met 
                405                 410                 415     


Asn Trp Gly Glu Glu Glu Glu Lys Gly Val Val Val Lys Arg Glu Lys 
            420                 425                 430         


Val Arg Glu Ala Ile Glu Arg Met Met Asp Gly Asp Glu Arg Glu Glu 
        435                 440                 445             


Arg Arg Glu Arg Cys Lys Glu Leu Ala Glu Thr Ala Lys Arg Ala Ile 
    450                 455                 460                 


Glu Glu Gly Gly Ser Ser His Arg Asn Leu Thr Leu Leu Ile Glu Asp 
465                 470                 475                 480 


Ile Gly Thr Ser Leu Arg Arg Leu 
                485             


<210>  29
<211>  1416
<212>  DNA
<213>  Siraitia grosvenori

<400>  29
atgatgagaa accaccattt ccttctggta tgtttccctt ctcaaggcta tataaaccct       60

tcccttcaac tcgccaggcg actgataagc ctcggcgtta atgtcacctt cgccaccacc      120

gtcctcgccg gccgccgcat gaagaacaaa acccaccaaa ctgcaacaac accaggcttg      180

tctttcgcta ctttctccga tggcttcgat gacgaaaccc tcaaacccaa cggcgacttg      240

acccactact tctcggagct caggcgctgc ggctctgaat ctctaaccca tctcattact      300

tctgcagcaa acgaaggtcg tccgattacc ttcgtaatct atagcctcct gctctcttgg      360

gcggctgata ttgccagcac atatgacatc ccgtcagcac ttttttttgc tcagcctgcg      420

acggttttgg ctttgtactt ctattacttc catggttatg gtgataccat ttgcagcaaa      480

ctccaagacc catcttcgta catagaatta ccaggtttgc cgttgctcac tagtcaggac      540

atgccctctt tcttctcccc ttccggcccc catgctttca ttctccctcc aatgagagag      600

caggctgaat tcctcggccg acaaagccaa ccaaaagtac tagtgaacac cttcgacgcg      660

ttagaggcag acgccttgag agccattgat aagttgaaga tgttggcgat tggacccttg      720

attccatctg ctttactggg tggaaacgat tcctctgatg catcattttg tggtgatctt      780

tttcaagtct cgtcagagga ttatatagaa tggttgaact ccaagcctga ctcgtcggtc      840

gtttacatat cagttggatc catctgcgtg ctgtctgatg aacaagagga cgagcttgtg      900

catgctttat taaacagtgg ccacacgttc ttgtgggtaa agagatcgaa agagaacaac      960

gaaggagtaa aacaagaaac agacgaggag aagttgaaga agctggaaga gcaagggaaa     1020

atggtgtcgt ggtgccgtca agttgaagtg ttgaaacacc ctgcgttggg ttgttttctg     1080

acgcactgtg ggtggaactc gactattgaa agcttggttt cagggctgcc ggtggttgct     1140

tttccgcagc agatagatca agccaccaac gcgaagctca tagaggacgt gtggaagacg     1200

ggagtgaggg tgaaggccaa tacagaagga attgtggaga gggaagaaat caggaggtgc     1260

ttggatttgg tgatggggag cagagatggg caaaaggaag agatagagag aaatgccaaa     1320

aagtggaaag aattggctag acaggccatc ggtgaaggtg ggtcatcaga ttcgaatctt     1380

aagacttttc tatgggagat tgatctagaa atttag                               1416


<210>  30
<211>  471
<212>  PRT
<213>  Siraitia grosvenori

<400>  30

Met Met Arg Asn His His Phe Leu Leu Val Cys Phe Pro Ser Gln Gly 
1               5                   10                  15      


Tyr Ile Asn Pro Ser Leu Gln Leu Ala Arg Arg Leu Ile Ser Leu Gly 
            20                  25                  30          


Val Asn Val Thr Phe Ala Thr Thr Val Leu Ala Gly Arg Arg Met Lys 
        35                  40                  45              


Asn Lys Thr His Gln Thr Ala Thr Thr Pro Gly Leu Ser Phe Ala Thr 
    50                  55                  60                  


Phe Ser Asp Gly Phe Asp Asp Glu Thr Leu Lys Pro Asn Gly Asp Leu 
65                  70                  75                  80  


Thr His Tyr Phe Ser Glu Leu Arg Arg Cys Gly Ser Glu Ser Leu Thr 
                85                  90                  95      


His Leu Ile Thr Ser Ala Ala Asn Glu Gly Arg Pro Ile Thr Phe Val 
            100                 105                 110         


Ile Tyr Ser Leu Leu Leu Ser Trp Ala Ala Asp Ile Ala Ser Thr Tyr 
        115                 120                 125             


Asp Ile Pro Ser Ala Leu Phe Phe Ala Gln Pro Ala Thr Val Leu Ala 
    130                 135                 140                 


Leu Tyr Phe Tyr Tyr Phe His Gly Tyr Gly Asp Thr Ile Cys Ser Lys 
145                 150                 155                 160 


Leu Gln Asp Pro Ser Ser Tyr Ile Glu Leu Pro Gly Leu Pro Leu Leu 
                165                 170                 175     


Thr Ser Gln Asp Met Pro Ser Phe Phe Ser Pro Ser Gly Pro His Ala 
            180                 185                 190         


Phe Ile Leu Pro Pro Met Arg Glu Gln Ala Glu Phe Leu Gly Arg Gln 
        195                 200                 205             


Ser Gln Pro Lys Val Leu Val Asn Thr Phe Asp Ala Leu Glu Ala Asp 
    210                 215                 220                 


Ala Leu Arg Ala Ile Asp Lys Leu Lys Met Leu Ala Ile Gly Pro Leu 
225                 230                 235                 240 


Ile Pro Ser Ala Leu Leu Gly Gly Asn Asp Ser Ser Asp Ala Ser Phe 
                245                 250                 255     


Cys Gly Asp Leu Phe Gln Val Ser Ser Glu Asp Tyr Ile Glu Trp Leu 
            260                 265                 270         


Asn Ser Lys Pro Asp Ser Ser Val Val Tyr Ile Ser Val Gly Ser Ile 
        275                 280                 285             


Cys Val Leu Ser Asp Glu Gln Glu Asp Glu Leu Val His Ala Leu Leu 
    290                 295                 300                 


Asn Ser Gly His Thr Phe Leu Trp Val Lys Arg Ser Lys Glu Asn Asn 
305                 310                 315                 320 


Glu Gly Val Lys Gln Glu Thr Asp Glu Glu Lys Leu Lys Lys Leu Glu 
                325                 330                 335     


Glu Gln Gly Lys Met Val Ser Trp Cys Arg Gln Val Glu Val Leu Lys 
            340                 345                 350         


His Pro Ala Leu Gly Cys Phe Leu Thr His Cys Gly Trp Asn Ser Thr 
        355                 360                 365             


Ile Glu Ser Leu Val Ser Gly Leu Pro Val Val Ala Phe Pro Gln Gln 
    370                 375                 380                 


Ile Asp Gln Ala Thr Asn Ala Lys Leu Ile Glu Asp Val Trp Lys Thr 
385                 390                 395                 400 


Gly Val Arg Val Lys Ala Asn Thr Glu Gly Ile Val Glu Arg Glu Glu 
                405                 410                 415     


Ile Arg Arg Cys Leu Asp Leu Val Met Gly Ser Arg Asp Gly Gln Lys 
            420                 425                 430         


Glu Glu Ile Glu Arg Asn Ala Lys Lys Trp Lys Glu Leu Ala Arg Gln 
        435                 440                 445             


Ala Ile Gly Glu Gly Gly Ser Ser Asp Ser Asn Leu Lys Thr Phe Leu 
    450                 455                 460                 


Trp Glu Ile Asp Leu Glu Ile 
465                 470     


<210>  31
<211>  1458
<212>  DNA
<213>  Siraitia grosvenori

<400>  31
atggcggagc aagctcatga tcttcttcac gtcctccttt ttccgtttcc ggcggagggc       60

cacatcaagc ccttcctctg tctcgccgag ctcctctgca acgccggctt ccatgtcacc      120

ttcctcaaca ccgactacaa ccaccgccgc ctccacaacc tccatctcct cgccgcccgc      180

tttccctcac ttcatttcga gtccatttcc gacggcctcc cgcccgatca gcctcgagat      240

atactggacc ccaagttttt tatatccatc tgtcaagtca ctaaacccct tttccgggag      300

ctcctccttt cctacaaacg catttccagt gtccagaccg gccgcccgcc aataacttgc      360

gttattacag atgtgatttt tcgttttccg atcgacgtag ctgaagaact ggatattcct      420

gtgtttagtt tctgtacttt cagtgcccgt ttcatgtttc tttacttctg gattcccaag      480

ctcattgaag atggccagct tccataccca aacggcaata tcaaccagaa actctacggt      540

gttgctcctg aggcggaagg ccttttaaga tgtaaagatt tgccgggaca ttgggctttc      600

gcagacgaac taaaagatga tcaacttaac tttgtggacc agacaacggc gtcatctcga      660

tcctccggtc tcattctcaa cacattcgac gacctcgaag ctccatttct ggggcgtctc      720

tccaccatct ttaagaaaat ctacgccgtt ggacccatcc actctctgtt gaactcccac      780

cactgtgggc tttggaaaga agatcacagt tgcctggcgt ggctcgactc ccgggccgcg      840

aaatccgtcg tgttcgtcag cttcgggagc ttggtgaaga taacaagtag gcagctgatg      900

gagttttggc atggcttgct caacagtgga aagtcgttcc tcttcgtgtt gagatctgac      960

gtagttgagg gcgatgatga aaaacaagtc gtcaaagaaa tttacgagac gaaggcagag     1020

gggaaatggt tggttgtggg gtgggctccg caagagaagg tgttagccca tgaagctgtt     1080

ggtggatttc tgacccattc gggctggaac tccattttag agagcattgc tgctggggtt     1140

cctatgatct cctgccccaa aattggagac cagtccagta actgtacgtg gatcagtaaa     1200

gtatggaaaa ttgggcttga aatggaggat cggtacgacc gggtttcggt cgaaacaatg     1260

gttagatcta taatggaaca agaaggtgag aaaatgcaga agacaattgc agaattagca     1320

aaacaagcta agtataaagt tagtaaagat ggaacatcat atcaaaattt agaatgttta     1380

atccaagata ttaaaaaact gaaccaaatt gagggtttta tcaacaaccc caattttagt     1440

gatttattaa gggtttag                                                   1458


<210>  32
<211>  485
<212>  PRT
<213>  Siraitia grosvenori

<400>  32

Met Ala Glu Gln Ala His Asp Leu Leu His Val Leu Leu Phe Pro Phe 
1               5                   10                  15      


Pro Ala Glu Gly His Ile Lys Pro Phe Leu Cys Leu Ala Glu Leu Leu 
            20                  25                  30          


Cys Asn Ala Gly Phe His Val Thr Phe Leu Asn Thr Asp Tyr Asn His 
        35                  40                  45              


Arg Arg Leu His Asn Leu His Leu Leu Ala Ala Arg Phe Pro Ser Leu 
    50                  55                  60                  


His Phe Glu Ser Ile Ser Asp Gly Leu Pro Pro Asp Gln Pro Arg Asp 
65                  70                  75                  80  


Ile Leu Asp Pro Lys Phe Phe Ile Ser Ile Cys Gln Val Thr Lys Pro 
                85                  90                  95      


Leu Phe Arg Glu Leu Leu Leu Ser Tyr Lys Arg Ile Ser Ser Val Gln 
            100                 105                 110         


Thr Gly Arg Pro Pro Ile Thr Cys Val Ile Thr Asp Val Ile Phe Arg 
        115                 120                 125             


Phe Pro Ile Asp Val Ala Glu Glu Leu Asp Ile Pro Val Phe Ser Phe 
    130                 135                 140                 


Cys Thr Phe Ser Ala Arg Phe Met Phe Leu Tyr Phe Trp Ile Pro Lys 
145                 150                 155                 160 


Leu Ile Glu Asp Gly Gln Leu Pro Tyr Pro Asn Gly Asn Ile Asn Gln 
                165                 170                 175     


Lys Leu Tyr Gly Val Ala Pro Glu Ala Glu Gly Leu Leu Arg Cys Lys 
            180                 185                 190         


Asp Leu Pro Gly His Trp Ala Phe Ala Asp Glu Leu Lys Asp Asp Gln 
        195                 200                 205             


Leu Asn Phe Val Asp Gln Thr Thr Ala Ser Ser Arg Ser Ser Gly Leu 
    210                 215                 220                 


Ile Leu Asn Thr Phe Asp Asp Leu Glu Ala Pro Phe Leu Gly Arg Leu 
225                 230                 235                 240 


Ser Thr Ile Phe Lys Lys Ile Tyr Ala Val Gly Pro Ile His Ser Leu 
                245                 250                 255     


Leu Asn Ser His His Cys Gly Leu Trp Lys Glu Asp His Ser Cys Leu 
            260                 265                 270         


Ala Trp Leu Asp Ser Arg Ala Ala Lys Ser Val Val Phe Val Ser Phe 
        275                 280                 285             


Gly Ser Leu Val Lys Ile Thr Ser Arg Gln Leu Met Glu Phe Trp His 
    290                 295                 300                 


Gly Leu Leu Asn Ser Gly Lys Ser Phe Leu Phe Val Leu Arg Ser Asp 
305                 310                 315                 320 


Val Val Glu Gly Asp Asp Glu Lys Gln Val Val Lys Glu Ile Tyr Glu 
                325                 330                 335     


Thr Lys Ala Glu Gly Lys Trp Leu Val Val Gly Trp Ala Pro Gln Glu 
            340                 345                 350         


Lys Val Leu Ala His Glu Ala Val Gly Gly Phe Leu Thr His Ser Gly 
        355                 360                 365             


Trp Asn Ser Ile Leu Glu Ser Ile Ala Ala Gly Val Pro Met Ile Ser 
    370                 375                 380                 


Cys Pro Lys Ile Gly Asp Gln Ser Ser Asn Cys Thr Trp Ile Ser Lys 
385                 390                 395                 400 


Val Trp Lys Ile Gly Leu Glu Met Glu Asp Arg Tyr Asp Arg Val Ser 
                405                 410                 415     


Val Glu Thr Met Val Arg Ser Ile Met Glu Gln Glu Gly Glu Lys Met 
            420                 425                 430         


Gln Lys Thr Ile Ala Glu Leu Ala Lys Gln Ala Lys Tyr Lys Val Ser 
        435                 440                 445             


Lys Asp Gly Thr Ser Tyr Gln Asn Leu Glu Cys Leu Ile Gln Asp Ile 
    450                 455                 460                 


Lys Lys Leu Asn Gln Ile Glu Gly Phe Ile Asn Asn Pro Asn Phe Ser 
465                 470                 475                 480 


Asp Leu Leu Arg Val 
                485 


<210>  33
<211>  1425
<212>  DNA
<213>  Siraitia grosvenori

<400>  33
atggtgcaac ctcgggtact gctgtttcct ttcccggcac tgggccacgt gaagcccttc       60

ttatcactgg cggagctgct ttccgacgcc ggcatagacg tcgtcttcct cagcaccgag      120

tataaccacc gtcggatctc caacactgaa gccctagcct cccgcttccc gacgcttcat      180

ttcgaaacta taccggatgg cctgccgcct aatgagtcgc gcgctcttgc cgacggccca      240

ctgtatttct ccatgcgtga gggaactaaa ccgagattcc ggcaactgat tcaatctctt      300

aacgacggtc gttggcccat cacctgtatt atcactgaca tcatgttatc ttctccgatt      360

gaagtagcgg aagaatttgg gattccagta attgccttct gcccctgcag tgctcgctac      420

ttatcgattc acttttttat accgaagctc gttgaggaag gtcaaattcc atacgcagat      480

gacgatccga ttggagagat ccagggggtg cccttgttcg aaggtctttt gcgacggaat      540

catttgcctg gttcttggtc tgataaatct gcagatatat ctttctcgca tggcttgatt      600

aatcagaccc ttgcagctgg tcgagcctcg gctcttatac tcaacacctt cgacgagctc      660

gaagctccat ttctgaccca tctctcttcc attttcaaca aaatctacac cattggaccc      720

ctccatgctc tgtccaaatc aaggctcggc gactcctcct cctccgcttc tgccctctcc      780

ggattctgga aagaggatag agcctgcatg tcctggctcg actgtcagcc gccgagatct      840

gtggttttcg tcagtttcgg gagtacgatg aagatgaaag ccgatgaatt gagagagttc      900

tggtatgggt tggtgagcag cgggaaaccg ttcctctgcg tgttgagatc cgacgttgtt      960

tccggcggag aagcggcgga attgatcgaa cagatggcgg aggaggaggg agctggaggg     1020

aagctgggaa tggtagtgga gtgggcagcg caagagaagg tcctgagcca ccctgccgtc     1080

ggtgggtttt tgacgcactg cgggtggaac tcaacggtgg aaagcattgc cgcgggagtt     1140

ccgatgatgt gctggccgat tctcggcgac caacccagca acgccacttg gatcgacaga     1200

gtgtggaaaa ttggggttga aaggaacaat cgtgaatggg acaggttgac ggtggagaag     1260

atggtgagag cattgatgga aggccaaaag agagtggaga ttcagagatc aatggagaag     1320

ctttcaaagt tggcaaatga gaaggttgtc aggggtgggt tgtcttttga taacttggaa     1380

gttctcgttg aagacatcaa aaaattgaaa ccatataaat tttaa                     1425


<210>  34
<211>  419
<212>  PRT
<213>  Siraitia grosvenori

<400>  34

Met Val Gln Pro Arg Val Leu Leu Phe Pro Phe Pro Ala Leu Gly His 
1               5                   10                  15      


Val Lys Pro Phe Leu Ser Leu Ala Glu Leu Leu Ser Asp Ala Gly Ile 
            20                  25                  30          


Asp Val Val Phe Leu Ser Thr Glu Tyr Asn His Arg Arg Ile Ser Asn 
        35                  40                  45              


Thr Glu Ala Leu Ala Ser Arg Phe Pro Thr Leu His Phe Glu Thr Ile 
    50                  55                  60                  


Pro Asp Gly Leu Pro Pro Asn Glu Ser Arg Ala Leu Ala Asp Gly Pro 
65                  70                  75                  80  


Leu Tyr Phe Ser Met Arg Glu Gly Thr Lys Pro Arg Phe Arg Gln Leu 
                85                  90                  95      


Ile Gln Ser Leu Asn Asp Gly Arg Trp Pro Ile Thr Cys Ile Ile Thr 
            100                 105                 110         


Asp Ile Met Leu Ser Ser Pro Ile Glu Val Ala Glu Glu Phe Gly Ile 
        115                 120                 125             


Pro Val Ile Ala Phe Cys Pro Cys Ser Ala Arg Tyr Leu Ser Ile His 
    130                 135                 140                 


Phe Phe Ile Pro Lys Leu Val Glu Glu Gly Gln Ile Pro Tyr Ala Asp 
145                 150                 155                 160 


Asp Asp Pro Ile Gly Glu Ile Gln Gly Val Pro Leu Phe Glu Gly Leu 
                165                 170                 175     


Leu Arg Arg Asn His Leu Pro Gly Ser Trp Ser Asp Lys Ser Ala Asp 
            180                 185                 190         


Ile Ser Phe Ser His Gly Leu Ile Asn Gln Thr Leu Ala Ala Gly Arg 
        195                 200                 205             


Ala Ser Ala Leu Ile Leu Asn Thr Phe Asp Glu Leu Glu Ala Pro Phe 
    210                 215                 220                 


Leu Thr His Leu Ser Ser Ile Phe Asn Lys Ile Tyr Thr Ile Gly Pro 
225                 230                 235                 240 


Leu His Ala Leu Ser Lys Ser Arg Leu Gly Asp Ser Ser Ser Ser Ala 
                245                 250                 255     


Ser Ala Leu Ser Gly Phe Trp Lys Glu Asp Arg Ala Cys Met Ser Trp 
            260                 265                 270         


Leu Asp Cys Gln Pro Pro Arg Ser Val Val Phe Val Ser Phe Gly Ser 
        275                 280                 285             


Thr Met Lys Met Lys Ala Asp Glu Leu Arg Glu Phe Trp Tyr Gly Leu 
    290                 295                 300                 


Val Ser Ser Gly Lys Pro Phe Leu Cys Val Leu Arg Ser Asp Val Val 
305                 310                 315                 320 


Ser Gly Gly Glu Ala Ala Glu Leu Ile Glu Gln Met Ala Glu Glu Glu 
                325                 330                 335     


Gly Ala Gly Gly Lys Leu Gly Met Val Val Glu Trp Ala Ala Gln Glu 
            340                 345                 350         


Lys Val Leu Ser His Pro Ala Val Gly Gly Phe Leu Thr His Cys Gly 
        355                 360                 365             


Trp Asn Ser Thr Val Glu Ser Ile Ala Ala Gly Val Pro Met Met Cys 
    370                 375                 380                 


Trp Pro Ile Leu Gly Asp Gln Pro Ser Asn Ala Thr Trp Ile Asp Arg 
385                 390                 395                 400 


Val Trp Lys Ile Gly Val Glu Arg Asn Asn Arg Glu Trp Asp Arg Leu 
                405                 410                 415     


Thr Val Glu 
            


<210>  35
<211>  1422
<212>  DNA
<213>  Siraitia grosvenori

<400>  35
atggatgccc agcaaggtca caccaccacc attttgatgc ttccatgggt cggctacggc       60

catctcttgc ctttcctcga gctggccaaa agcctctcca ggaggaaatt attccacatc      120

tacttctgtt caacgtctgt tagcctcgac gccattaaac caaagcttcc tccttctatc      180

tcttctgatg attccatcca acttgtggaa cttcgtctcc cttcttctcc tgagttacct      240

cctcatcttc acacaaccaa cggccttccc tctcacctca tgcccgctct ccaccaagcc      300

ttcgtcatgg ctgcccaaca ctttcaggtc attttacaaa cacttgcccc gcatctcctc      360

atttatgaca ttctccaacc ttgggctcct caagtggctt catccctcaa cattccagcc      420

atcaacttca gtactaccgg agcttcaatg ctttctcgaa cgcttcaccc tactcactac      480

ccaagttcta aattcccaat ctcagagttt gttcttcaca atcactggag agccatgtac      540

accaccgccg atggggctct tacagaagaa ggccacaaaa ttgaagaaac acttgcgaat      600

tgcttgcata cttcttgcgg ggtagttttg gtcaatagtt tcagagagct tgagacgaaa      660

tatatcgatt atctctctgt tctcttgaac aagaaagttg ttccggtcgg tcctttggtt      720

tacgaaccga atcaagaagg ggaagatgaa ggttattcaa gcatcaaaaa ttggcttgac      780

aaaaaggaac cgtcctcaac cgtcttcgtt tcatttggaa ccgaatactt cccgtcaaag      840

gaagaaatgg aagagatagc gtatgggtta gagctgagcg aggttaattt catctgggtc      900

cttagatttc ctcaaggaga cagcaccagc accattgaag acgccttgcc gaaggggttt      960

ctggagagag cgggagagag ggcgatggtg gtgaagggtt gggctcctca ggcgaagata     1020

ctgaagcatt ggagcacagg ggggcttgtg agtcactgtg gatggaactc gatgatggag     1080

ggcatgatgt ttggcgtacc cataatagcg gttccgatgc atctggacca gccctttaac     1140

gccggactcg tggaagaagc tggcgtcggc gtggaagcca agcgagattc ggacggcaaa     1200

attcaaagag aagaagttgc aaagtcgatc aaagaagtgg tgattgagaa aaccagggaa     1260

gacgtgagga agaaagcaag agaaatggac accaaacacg gacctaccta ttttagtcgg     1320

tcgaaagtta gcagttttgg aaggctatat aaaatcaacc gaccaactac actgacggtt     1380

ggtcgatttt ggtcgaaaca gatcaagatg aagcgagagt aa                        1422


<210>  36
<211>  459
<212>  PRT
<213>  Siraitia grosvenori

<400>  36

Met Asp Ala Gln Gln Gly His Thr Thr Thr Ile Leu Met Leu Pro Trp 
1               5                   10                  15      


Val Gly Tyr Gly His Leu Leu Pro Phe Leu Glu Leu Ala Lys Ser Leu 
            20                  25                  30          


Ser Arg Arg Lys Leu Phe His Ile Tyr Phe Cys Ser Thr Ser Val Ser 
        35                  40                  45              


Leu Asp Ala Ile Lys Pro Lys Leu Pro Pro Ser Ile Ser Ser Asp Asp 
    50                  55                  60                  


Ser Ile Gln Leu Val Glu Leu Arg Leu Pro Ser Ser Pro Glu Leu Pro 
65                  70                  75                  80  


Pro His Leu His Thr Thr Asn Gly Leu Pro Ser His Leu Met Pro Ala 
                85                  90                  95      


Leu His Gln Ala Phe Val Met Ala Ala Gln His Phe Gln Val Ile Leu 
            100                 105                 110         


Gln Thr Leu Ala Pro His Leu Leu Ile Tyr Asp Ile Leu Gln Pro Trp 
        115                 120                 125             


Ala Pro Gln Val Ala Ser Ser Leu Asn Ile Pro Ala Ile Asn Phe Ser 
    130                 135                 140                 


Thr Thr Gly Ala Ser Met Leu Ser Arg Thr Leu His Pro Thr His Tyr 
145                 150                 155                 160 


Pro Ser Ser Lys Phe Pro Ile Ser Glu Phe Val Leu His Asn His Trp 
                165                 170                 175     


Arg Ala Met Tyr Thr Thr Ala Asp Gly Ala Leu Thr Glu Glu Gly His 
            180                 185                 190         


Lys Ile Glu Glu Thr Leu Ala Asn Cys Leu His Thr Ser Cys Gly Val 
        195                 200                 205             


Val Leu Val Asn Ser Phe Arg Glu Leu Glu Thr Lys Tyr Ile Asp Tyr 
    210                 215                 220                 


Leu Ser Val Leu Leu Asn Lys Lys Val Val Pro Val Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Glu Pro Asn Gln Glu Gly Glu Asp Glu Gly Tyr Ser Ser Ile Lys 
                245                 250                 255     


Asn Trp Leu Asp Lys Lys Glu Pro Ser Ser Thr Val Phe Val Ser Phe 
            260                 265                 270         


Gly Thr Glu Tyr Phe Pro Ser Lys Glu Glu Met Glu Glu Ile Ala Tyr 
        275                 280                 285             


Gly Leu Glu Leu Ser Glu Val Asn Phe Ile Trp Val Leu Arg Phe Pro 
    290                 295                 300                 


Gln Gly Asp Ser Thr Ser Thr Ile Glu Asp Ala Leu Pro Lys Gly Phe 
305                 310                 315                 320 


Leu Glu Arg Ala Gly Glu Arg Ala Met Val Val Lys Gly Trp Ala Pro 
                325                 330                 335     


Gln Ala Lys Ile Leu Lys His Trp Ser Thr Gly Gly Leu Val Ser His 
            340                 345                 350         


Cys Gly Trp Asn Ser Met Met Glu Gly Met Met Phe Gly Val Pro Ile 
        355                 360                 365             


Ile Ala Val Pro Met His Leu Asp Gln Pro Phe Asn Ala Gly Leu Val 
    370                 375                 380                 


Glu Glu Ala Gly Val Gly Val Glu Ala Lys Arg Asp Ser Asp Gly Lys 
385                 390                 395                 400 


Ile Gln Arg Glu Glu Val Ala Lys Ser Ile Lys Glu Val Val Ile Glu 
                405                 410                 415     


Lys Thr Arg Glu Asp Val Arg Lys Lys Ala Arg Glu Met Gly Glu Ile 
            420                 425                 430         


Leu Arg Ser Lys Gly Asp Glu Lys Ile Asp Glu Leu Val Ala Glu Ile 
        435                 440                 445             


Ser Leu Leu Arg Lys Lys Ala Pro Cys Ser Ile 
    450                 455                 


<210>  37
<211>  1359
<212>  DNA
<213>  Siraitia grosvenori

<400>  37
atggatgctg cccaacaagg tgacaccaca accattttga tgcttccatg gctcggctat       60

ggccatcttt cagcttttct cgagctggcc aaaagcctct caaggaggaa cttccatatc      120

tacttctgtt caacctctgt taatcttgac gccattaaac caaagcttcc ttcttctttc      180

tctgattcca ttcaatttgt ggagctccat ctcccttctt ctcctgagtt ccctcctcat      240

cttcacacaa ccaacggcct tccccctacc ctcatgcccg ctctccacca agccttctcc      300

atggctgccc agcactttga gtccatttta caaacacttg ccccgcacct tctcatttat      360

gactctcttc aaccttgggc tcctcgggta gcttcatccc tcaaaattcc ggccatcaac      420

ttcaatacca cgggagtttt cgtcatttct caagggyttc accctattca ctacccacat      480

tctaaattcc cattctcaga gttcgttctt cacaatcatt ggaaagccat gtactccact      540

gccgatggag cttctaccga aagaacccgc aaacgtggag aagcgtttct gtattgcttg      600

catgcttctt gtagtgtaat tctaatcaat agtttcagag agctcgaggg gaaatatatg      660

gattatctct ctgttctctt gaacaagaaa gttgttccgg ttggtccttt ggtttacgaa      720

ccgaatcaag acggggaaga tgaaggttat tcaagcatca aaaattggct tgacaaaaag      780

gaaccgtcct ccaccgtctt cgtgtcattt ggaagcgaat acttcccgtc aaaggaagaa      840

atggaagaga tagcccatgg gttagaggcg agcgaggtta atttcatctg ggtcgttagg      900

tttcctcaag gagacaacac cagcggcatt gaagatgcct tgccgaaggg ttttctggag      960

agggcgggag agagagggat ggtggtgaag ggttgggctc ctcaggcgaa gatactgaag     1020

cattggagca cagggggatt cgtgagccac tgtggatgga actcggtgat ggagagcatg     1080

atgtttggcg ttcccataat aggggttccg atgcatgtgg accagccctt taacgccgga     1140

ctcgtggaag aagctggcgt cggcgtggag gccaagcgag atccagacgg caaaattcaa     1200

agagacgaag ttgcaaagtt gatcaaagaa gtggtggttg agaaaaccag agaagatgtg     1260

cggaagaaag caagagaaat gagtgagatt ttgaggagca agggagagga gaagtttgat     1320

gagatggtcg ctgaaatttc tctcttgctt aaaatatga                            1359


<210>  38
<211>  452
<212>  PRT
<213>  Siraitia grosvenori

<400>  38

Met Asp Ala Ala Gln Gln Gly Asp Thr Thr Thr Ile Leu Met Leu Pro 
1               5                   10                  15      


Trp Leu Gly Tyr Gly His Leu Ser Ala Phe Leu Glu Leu Ala Lys Ser 
            20                  25                  30          


Leu Ser Arg Arg Asn Phe His Ile Tyr Phe Cys Ser Thr Ser Val Asn 
        35                  40                  45              


Leu Asp Ala Ile Lys Pro Lys Leu Pro Ser Ser Phe Ser Asp Ser Ile 
    50                  55                  60                  


Gln Phe Val Glu Leu His Leu Pro Ser Ser Pro Glu Phe Pro Pro His 
65                  70                  75                  80  


Leu His Thr Thr Asn Gly Leu Pro Pro Thr Leu Met Pro Ala Leu His 
                85                  90                  95      


Gln Ala Phe Ser Met Ala Ala Gln His Phe Glu Ser Ile Leu Gln Thr 
            100                 105                 110         


Leu Ala Pro His Leu Leu Ile Tyr Asp Ser Leu Gln Pro Trp Ala Pro 
        115                 120                 125             


Arg Val Ala Ser Ser Leu Lys Ile Pro Ala Ile Asn Phe Asn Thr Thr 
    130                 135                 140                 


Gly Val Phe Val Ile Ser Gln Gly Leu His Pro Ile His Tyr Pro His 
145                 150                 155                 160 


Ser Lys Phe Pro Phe Ser Glu Phe Val Leu His Asn His Trp Lys Ala 
                165                 170                 175     


Met Tyr Ser Thr Ala Asp Gly Ala Ser Thr Glu Arg Thr Arg Lys Arg 
            180                 185                 190         


Gly Glu Ala Phe Leu Tyr Cys Leu His Ala Ser Cys Ser Val Ile Leu 
        195                 200                 205             


Ile Asn Ser Phe Arg Glu Leu Glu Gly Lys Tyr Met Asp Tyr Leu Ser 
    210                 215                 220                 


Val Leu Leu Asn Lys Lys Val Val Pro Val Gly Pro Leu Val Tyr Glu 
225                 230                 235                 240 


Pro Asn Gln Asp Gly Glu Asp Glu Gly Tyr Ser Ser Ile Lys Asn Trp 
                245                 250                 255     


Leu Asp Lys Lys Glu Pro Ser Ser Thr Val Phe Val Ser Phe Gly Ser 
            260                 265                 270         


Glu Tyr Phe Pro Ser Lys Glu Glu Met Glu Glu Ile Ala His Gly Leu 
        275                 280                 285             


Glu Ala Ser Glu Val Asn Phe Ile Trp Val Val Arg Phe Pro Gln Gly 
    290                 295                 300                 


Asp Asn Thr Ser Gly Ile Glu Asp Ala Leu Pro Lys Gly Phe Leu Glu 
305                 310                 315                 320 


Arg Ala Gly Glu Arg Gly Met Val Val Lys Gly Trp Ala Pro Gln Ala 
                325                 330                 335     


Lys Ile Leu Lys His Trp Ser Thr Gly Gly Phe Val Ser His Cys Gly 
            340                 345                 350         


Trp Asn Ser Val Met Glu Ser Met Met Phe Gly Val Pro Ile Ile Gly 
        355                 360                 365             


Val Pro Met His Val Asp Gln Pro Phe Asn Ala Gly Leu Val Glu Glu 
    370                 375                 380                 


Ala Gly Val Gly Val Glu Ala Lys Arg Asp Pro Asp Gly Lys Ile Gln 
385                 390                 395                 400 


Arg Asp Glu Val Ala Lys Leu Ile Lys Glu Val Val Val Glu Lys Thr 
                405                 410                 415     


Arg Glu Asp Val Arg Lys Lys Ala Arg Glu Met Ser Glu Ile Leu Arg 
            420                 425                 430         


Ser Lys Gly Glu Glu Lys Phe Asp Glu Met Val Ala Glu Ile Ser Leu 
        435                 440                 445             


Leu Leu Lys Ile 
    450         


<210>  39
<211>  317
<212>  PRT
<213>  Siraitia grosvenori

<400>  39

Met Asp Ala Ile Glu His Arg Thr Val Ser Val Asn Gly Ile Asn Met 
1               5                   10                  15      


His Val Ala Glu Lys Gly Glu Gly Pro Val Val Leu Leu Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Ile Leu Ala Leu Ser 
        35                  40                  45              


Ser Leu Gly Tyr Arg Ala Val Ala Pro Asp Leu Arg Gly Tyr Gly Asp 
    50                  55                  60                  


Thr Asp Ala Pro Gly Ser Ile Ser Ser Tyr Thr Cys Phe His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Val Ala Leu Val Glu Ser Leu Gly Met Asp Arg Val Phe 
                85                  90                  95      


Val Val Ala His Asp Trp Gly Ala Met Ile Ala Trp Cys Leu Cys Leu 
            100                 105                 110         


Phe Arg Pro Glu Met Val Lys Ala Phe Val Cys Leu Ser Val Pro Phe 
        115                 120                 125             


Arg Gln Arg Asn Pro Lys Met Lys Pro Val Gln Ser Met Arg Ala Phe 
    130                 135                 140                 


Phe Gly Asp Asp Tyr Tyr Ile Cys Arg Phe Gln Asn Pro Gly Glu Ile 
145                 150                 155                 160 


Glu Glu Glu Met Ala Gln Val Gly Ala Arg Glu Val Leu Arg Gly Ile 
                165                 170                 175     


Leu Thr Ser Arg Arg Pro Gly Pro Pro Ile Leu Pro Lys Gly Gln Ala 
            180                 185                 190         


Phe Arg Ala Arg Pro Gly Ala Ser Thr Ala Leu Pro Ser Trp Leu Ser 
        195                 200                 205             


Glu Lys Asp Leu Ser Phe Phe Ala Ser Lys Tyr Asp Gln Lys Gly Phe 
    210                 215                 220                 


Thr Gly Pro Leu Asn Tyr Tyr Arg Ala Met Asp Leu Asn Trp Glu Leu 
225                 230                 235                 240 


Thr Ala Ser Trp Thr Gly Val Gln Val Lys Val Pro Val Lys Tyr Ile 
                245                 250                 255     


Val Gly Asp Val Asp Met Val Phe Thr Thr Pro Gly Val Lys Glu Tyr 
            260                 265                 270         


Val Asn Gly Gly Gly Phe Lys Lys Asp Val Pro Phe Leu Gln Glu Val 
        275                 280                 285             


Val Ile Met Glu Gly Val Gly His Phe Ile Asn Gln Glu Lys Pro Glu 
    290                 295                 300                 


Glu Ile Ser Ser His Ile His Asp Phe Ile Ser Lys Phe 
305                 310                 315         


<210>  40
<211>  316
<212>  PRT
<213>  Siraitia grosvenori

<400>  40

Met Asp Glu Ile Glu His Ile Thr Ile Asn Thr Asn Gly Ile Lys Met 
1               5                   10                  15      


His Ile Ala Ser Val Gly Thr Gly Pro Val Val Leu Leu Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Leu Leu Tyr Leu Ser 
        35                  40                  45              


Ser Val Gly Tyr Arg Ala Ile Ala Pro Asp Leu Arg Gly Tyr Gly Asp 
    50                  55                  60                  


Thr Asp Ser Pro Ala Ser Pro Thr Ser Tyr Thr Ala Leu His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Val Gly Ala Leu Asp Glu Leu Gly Ile Glu Lys Val Phe 
                85                  90                  95      


Leu Val Gly His Asp Trp Gly Ala Ile Ile Ala Trp Tyr Phe Cys Leu 
            100                 105                 110         


Phe Arg Pro Asp Arg Ile Lys Ala Leu Val Asn Leu Ser Val Gln Phe 
        115                 120                 125             


Ile Pro Arg Asn Pro Ala Ile Pro Phe Ile Glu Gly Phe Arg Thr Ala 
    130                 135                 140                 


Phe Gly Asp Asp Phe Tyr Ile Cys Arg Phe Gln Val Pro Gly Glu Ala 
145                 150                 155                 160 


Glu Glu Asp Phe Ala Ser Ile Asp Thr Ala Gln Leu Phe Lys Thr Ser 
                165                 170                 175     


Leu Cys Asn Arg Ser Ser Ala Pro Pro Cys Leu Pro Lys Glu Ile Gly 
            180                 185                 190         


Phe Arg Ala Ile Pro Pro Pro Glu Asn Leu Pro Ser Trp Leu Thr Glu 
        195                 200                 205             


Glu Asp Ile Asn Phe Tyr Ala Ala Lys Phe Lys Gln Thr Gly Phe Thr 
    210                 215                 220                 


Gly Ala Leu Asn Tyr Tyr Arg Ala Phe Asp Leu Thr Trp Glu Leu Thr 
225                 230                 235                 240 


Ala Pro Trp Thr Gly Ala Gln Ile Gln Val Pro Val Lys Phe Ile Val 
                245                 250                 255     


Gly Asp Ser Asp Leu Thr Tyr His Phe Pro Gly Ala Lys Glu Tyr Ile 
            260                 265                 270         


His Asn Gly Gly Phe Lys Arg Asp Val Pro Leu Leu Glu Glu Val Val 
        275                 280                 285             


Val Val Lys Asp Ala Cys His Phe Ile Asn Gln Glu Arg Pro Gln Glu 
    290                 295                 300                 


Ile Asn Ala His Ile His Asp Phe Ile Asn Lys Phe 
305                 310                 315     


<210>  41
<211>  325
<212>  PRT
<213>  Siraitia grosvenori

<400>  41

Met Glu Lys Glu Ser Glu Ile His Ser Ile Arg His Thr Thr Val Ser 
1               5                   10                  15      


Val Asn Gly Ile Asn Met His Val Ala Glu Lys Gly Glu Gly Pro Leu 
            20                  25                  30          


Val Leu Phe Ile His Gly Phe Pro Glu Leu Trp Tyr Ser Trp Arg His 
        35                  40                  45              


Gln Ile Leu Asp Leu Ala Ser Leu Gly Tyr Arg Ala Val Ala Pro Asp 
    50                  55                  60                  


Leu Arg Gly Tyr Gly Asp Ser Asp Ala Pro Pro Ser Ala Ser Ser Tyr 
65                  70                  75                  80  


Thr Ser Phe His Ile Val Gly Asp Leu Ile Ala Leu Leu Asp Ala Ile 
                85                  90                  95      


Val Gly Val Glu Glu Lys Val Phe Val Val Ala His Asp Trp Gly Ala 
            100                 105                 110         


Ile Ile Ala Trp Tyr Leu Cys Leu Tyr Arg Pro Asp Arg Ile Lys Ala 
        115                 120                 125             


Leu Val Asn Leu Ser Val Ala Phe Ile Arg Arg Asn Pro Lys Gly Lys 
    130                 135                 140                 


Pro Val Glu Trp Ile Arg Ala Leu Tyr Gly Asp Asp His Tyr Met Cys 
145                 150                 155                 160 


Arg Cys Gln Glu Pro Gly Glu Ile Glu Gly Glu Phe Ala Glu Ile Gly 
                165                 170                 175     


Thr Glu Arg Val Leu Thr Gln Phe Leu Thr Tyr His Ser Pro Lys Pro 
            180                 185                 190         


Leu Met Leu Pro Lys Gly Lys Ala Phe Gly His Pro Leu Asp Thr Pro 
        195                 200                 205             


Ile Pro Leu Pro Pro Trp Leu Ser His Gln Asp Ile Glu Tyr Tyr Ala 
    210                 215                 220                 


Ser Lys Phe Asp Lys Lys Gly Phe Thr Gly Pro Val Asn Tyr Tyr Arg 
225                 230                 235                 240 


Asn Leu Asp Arg Asn Trp Glu Leu Asn Ala Pro Phe Thr Arg Ala Gln 
                245                 250                 255     


Val Lys Val Pro Val Lys Phe Ile Val Gly Asp Leu Asp Leu Thr Tyr 
            260                 265                 270         


His Ser Phe Gly Thr Lys Glu Tyr Ile His Ser Gly Glu Met Lys Lys 
        275                 280                 285             


Asp Val Pro Phe Leu Gln Glu Val Val Val Met Glu Gly Val Gly His 
    290                 295                 300                 


Phe Ile Gln Ser Glu Lys Pro His Glu Ile Ser Asp His Ile Tyr Gln 
305                 310                 315                 320 


Phe Ile Lys Lys Phe 
                325 


<210>  42
<211>  316
<212>  PRT
<213>  Siraitia grosvenori

<400>  42

Met Glu Lys Ile Glu His Thr Ile Ile Thr Thr Asn Gly Ile Asn Met 
1               5                   10                  15      


His Val Ala Ser Ile Gly Thr Gly Pro Ala Val Leu Phe Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Leu Leu Ser Phe Ser 
        35                  40                  45              


Ser Leu Gly Tyr Arg Ala Ile Ala Pro Asp Leu Arg Gly Tyr Gly Asp 
    50                  55                  60                  


Ser Asp Ala Pro Pro Ser Pro Ser Ser Tyr Thr Val Phe His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Val Gly Leu Leu Asp Gln Leu Gly Ile Asp Gln Val Phe 
                85                  90                  95      


Leu Val Gly His Asp Trp Gly Ala Ser Ile Ala Trp Tyr Phe Ser Leu 
            100                 105                 110         


Leu Arg Pro Asp Arg Ile Lys Ala Leu Val Asn Leu Ser Val Gln Tyr 
        115                 120                 125             


Phe Pro Arg Asn Pro Ala Arg Asn Thr Val Glu Ala Leu Arg Ala Leu 
    130                 135                 140                 


Phe Gly Asp Asp Tyr Tyr Val Cys Arg Phe Gln Glu Pro Gly Glu Met 
145                 150                 155                 160 


Glu Glu Asp Phe Ala Ser Ile Asp Thr Ala Val Ile Phe Lys Ile Phe 
                165                 170                 175     


Leu Ser Ser Arg Asp Pro Arg Pro Pro Cys Ile Pro Lys Ala Val Gly 
            180                 185                 190         


Phe Arg Ala Phe Pro Val Pro Asp Ser Leu Pro Ser Trp Leu Ser Glu 
        195                 200                 205             


Glu Asp Ile Ser Tyr Tyr Ala Ser Lys Phe Ser Lys Lys Gly Phe Thr 
    210                 215                 220                 


Gly Gly Leu Asn Tyr Tyr Arg Ala Leu Ala Leu Asn Trp Glu Leu Thr 
225                 230                 235                 240 


Ala Pro Trp Thr Gly Thr Gln Ile Lys Val Pro Thr Lys Phe Ile Val 
                245                 250                 255     


Gly Asp Leu Asp Leu Thr Tyr His Ile Pro Gly Ser Lys Glu Tyr Ile 
            260                 265                 270         


His Lys Gly Gly Phe Glu Arg Asp Val Pro Ser Leu Glu Glu Val Val 
        275                 280                 285             


Val Ile Glu Gly Ala Ala His Phe Val Asn Gln Glu Arg Pro Glu Glu 
    290                 295                 300                 


Ile Ser Lys His Ile Tyr Asp Phe Ile Lys Lys Phe 
305                 310                 315     


<210>  43
<211>  317
<212>  PRT
<213>  Siraitia grosvenori

<400>  43

Met Asp Ala Ile Glu His Arg Thr Val Ser Val Asn Gly Ile Asn Met 
1               5                   10                  15      


His Val Ala Glu Lys Gly Glu Gly Pro Val Val Leu Leu Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Ile Leu Ala Leu Ser 
        35                  40                  45              


Ser Leu Gly Tyr Arg Ala Val Ala Pro Asp Leu Arg Gly Tyr Gly Asp 
    50                  55                  60                  


Thr Asp Ala Pro Gly Ser Ile Ser Ser Tyr Thr Cys Phe His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Val Ala Leu Val Glu Ser Leu Gly Val Asp Arg Val Phe 
                85                  90                  95      


Val Val Ala His Asp Trp Gly Ala Met Ile Ala Trp Cys Leu Cys Leu 
            100                 105                 110         


Phe Arg Pro Glu Met Val Lys Ala Phe Val Cys Leu Ser Val Pro Phe 
        115                 120                 125             


Arg Gln Arg Asn Pro Lys Met Lys Pro Val Gln Ser Met Arg Ala Phe 
    130                 135                 140                 


Phe Gly Asp Asp Tyr Tyr Ile Cys Arg Phe Gln Asn Pro Gly Glu Ile 
145                 150                 155                 160 


Glu Glu Glu Met Ala Gln Val Gly Ala Arg Glu Val Leu Arg Gly Ile 
                165                 170                 175     


Leu Thr Ser Arg Arg Pro Gly Pro Pro Ile Leu Pro Lys Gly Gln Ala 
            180                 185                 190         


Phe Arg Ala Arg Pro Gly Ala Ser Thr Ala Leu Pro Ser Trp Leu Ser 
        195                 200                 205             


Glu Lys Asp Leu Ser Phe Phe Ala Ser Lys Tyr Asp Gln Lys Gly Phe 
    210                 215                 220                 


Thr Gly Pro Leu Asn Tyr Tyr Arg Ala Met Asp Leu Asn Trp Glu Leu 
225                 230                 235                 240 


Thr Ala Ser Trp Thr Gly Val Gln Val Lys Val Pro Val Lys Tyr Ile 
                245                 250                 255     


Val Gly Asp Val Asp Met Val Phe Thr Thr Pro Gly Val Lys Glu Tyr 
            260                 265                 270         


Val Asn Gly Gly Gly Phe Lys Lys Asp Val Pro Phe Leu Gln Glu Val 
        275                 280                 285             


Val Ile Met Glu Gly Val Gly His Phe Ile Asn Gln Glu Lys Pro Glu 
    290                 295                 300                 


Glu Ile Ser Ser His Ile His Asp Phe Ile Ser Arg Phe 
305                 310                 315         


<210>  44
<211>  311
<212>  PRT
<213>  Siraitia grosvenori

<400>  44

Met Asp Gln Ile Gln His Lys Phe Ile Asp Ile Arg Gly Leu Lys Leu 
1               5                   10                  15      


His Ile Ala Glu Ile Gly Thr Gly Ser Pro Ala Val Val Phe Leu His 
            20                  25                  30          


Gly Phe Pro Glu Ile Trp Tyr Ser Trp Arg His Gln Met Val Ala Ala 
        35                  40                  45              


Ala Ala Val Gly Tyr Arg Ala Ile Ser Pro Asp Leu Arg Gly Tyr Gly 
    50                  55                  60                  


Phe Ser Asp Pro His Pro Gln Pro Gln Asn Ala Ser Phe Asp Asp Phe 
65                  70                  75                  80  


Val Glu Asp Thr Leu Ala Ile Leu Asp Phe Leu His Ile Pro Lys Ala 
                85                  90                  95      


Phe Leu Val Gly Lys Asp Phe Gly Ser Trp Pro Val Tyr Leu Phe Ser 
            100                 105                 110         


Leu Val His Pro Thr Arg Val Ala Gly Ile Val Ser Leu Gly Val Pro 
        115                 120                 125             


Phe Leu Pro Pro Asn Pro Lys Arg Tyr Arg Asp Leu Pro Glu Gly Phe 
    130                 135                 140                 


Tyr Ile Phe Arg Trp Lys Glu Ser Gly Arg Ala Glu Ala Asp Phe Gly 
145                 150                 155                 160 


Arg Phe Asp Val Lys Thr Val Leu Arg Arg Ile Tyr Thr Leu Phe Ser 
                165                 170                 175     


Arg Ser Glu Ile Pro Ile Ala Glu Lys Asp Gln Glu Ile Met Asp Met 
            180                 185                 190         


Val Asp Glu Ser Thr Pro Pro Pro Pro Trp Leu Thr Asp Glu Asp Leu 
        195                 200                 205             


Ala Ala Tyr Ala Thr Ala Tyr Glu His Ser Gly Phe Glu Ser Ala Leu 
    210                 215                 220                 


Gln Val Pro Tyr Arg Arg Arg His Gln Glu Leu Gly Met Ser Asn Pro 
225                 230                 235                 240 


Arg Val Asp Val Pro Val Leu Leu Ile Ile Gly Gly Lys Asp Tyr Phe 
                245                 250                 255     


Leu Lys Phe Pro Gly Ile Glu Asp Tyr Ile Lys Ser Glu Lys Met Arg 
            260                 265                 270         


Glu Ile Val Pro Asp Leu Glu Val Ala Asp Leu Ala Asp Gly Thr His 
        275                 280                 285             


Phe Met Gln Glu Gln Phe Pro Ala Gln Val Asn His Leu Leu Ile Ser 
    290                 295                 300                 


Phe Leu Gly Lys Arg Asn Thr 
305                 310     


<210>  45
<211>  759
<212>  PRT
<213>  Siraitia grosvenorii

<400>  45

Met Trp Arg Leu Lys Val Gly Ala Glu Ser Val Gly Glu Asn Asp Glu 
1               5                   10                  15      


Lys Trp Leu Lys Ser Ile Ser Asn His Leu Gly Arg Gln Val Trp Glu 
            20                  25                  30          


Phe Cys Pro Asp Ala Gly Thr Gln Gln Gln Leu Leu Gln Val His Lys 
        35                  40                  45              


Ala Arg Lys Ala Phe His Asp Asp Arg Phe His Arg Lys Gln Ser Ser 
    50                  55                  60                  


Asp Leu Phe Ile Thr Ile Gln Tyr Gly Lys Glu Val Glu Asn Gly Gly 
65                  70                  75                  80  


Lys Thr Ala Gly Val Lys Leu Lys Glu Gly Glu Glu Val Arg Lys Glu 
                85                  90                  95      


Ala Val Glu Ser Ser Leu Glu Arg Ala Leu Ser Phe Tyr Ser Ser Ile 
            100                 105                 110         


Gln Thr Ser Asp Gly Asn Trp Ala Ser Asp Leu Gly Gly Pro Met Phe 
        115                 120                 125             


Leu Leu Pro Gly Leu Val Ile Ala Leu Tyr Val Thr Gly Val Leu Asn 
    130                 135                 140                 


Ser Val Leu Ser Lys His His Arg Gln Glu Met Cys Arg Tyr Val Tyr 
145                 150                 155                 160 


Asn His Gln Asn Glu Asp Gly Gly Trp Gly Leu His Ile Glu Gly Pro 
                165                 170                 175     


Ser Thr Met Phe Gly Ser Ala Leu Asn Tyr Val Ala Leu Arg Leu Leu 
            180                 185                 190         


Gly Glu Asp Ala Asn Ala Gly Ala Met Pro Lys Ala Arg Ala Trp Ile 
        195                 200                 205             


Leu Asp His Gly Gly Ala Thr Gly Ile Thr Ser Trp Gly Lys Leu Trp 
    210                 215                 220                 


Leu Ser Val Leu Gly Val Tyr Glu Trp Ser Gly Asn Asn Pro Leu Pro 
225                 230                 235                 240 


Pro Glu Phe Trp Leu Phe Pro Tyr Phe Leu Pro Phe His Pro Gly Arg 
                245                 250                 255     


Met Trp Cys His Cys Arg Met Val Tyr Leu Pro Met Ser Tyr Leu Tyr 
            260                 265                 270         


Gly Lys Arg Phe Val Gly Pro Ile Thr Pro Ile Val Leu Ser Leu Arg 
        275                 280                 285             


Lys Glu Leu Tyr Ala Val Pro Tyr His Glu Ile Asp Trp Asn Lys Ser 
    290                 295                 300                 


Arg Asn Thr Cys Ala Lys Glu Asp Leu Tyr Tyr Pro His Pro Lys Met 
305                 310                 315                 320 


Gln Asp Ile Leu Trp Gly Ser Leu His His Val Tyr Glu Pro Leu Phe 
                325                 330                 335     


Thr Arg Trp Pro Ala Lys Arg Leu Arg Glu Lys Ala Leu Gln Thr Ala 
            340                 345                 350         


Met Gln His Ile His Tyr Glu Asp Glu Asn Thr Arg Tyr Ile Cys Leu 
        355                 360                 365             


Gly Pro Val Asn Lys Val Leu Asn Leu Leu Cys Cys Trp Val Glu Asp 
    370                 375                 380                 


Pro Tyr Ser Asp Ala Phe Lys Leu His Leu Gln Arg Val His Asp Tyr 
385                 390                 395                 400 


Leu Trp Val Ala Glu Asp Gly Met Lys Met Gln Gly Tyr Asn Gly Ser 
                405                 410                 415     


Gln Leu Trp Asp Thr Ala Phe Ser Ile Gln Ala Ile Val Ser Thr Lys 
            420                 425                 430         


Leu Val Asp Asn Tyr Gly Pro Thr Leu Arg Lys Ala His Asp Phe Val 
        435                 440                 445             


Lys Ser Ser Gln Ile Gln Gln Asp Cys Pro Gly Asp Pro Asn Val Trp 
    450                 455                 460                 


Tyr Arg His Ile His Lys Gly Ala Trp Pro Phe Ser Thr Arg Asp His 
465                 470                 475                 480 


Gly Trp Leu Ile Ser Asp Cys Thr Ala Glu Gly Leu Lys Ala Ala Leu 
                485                 490                 495     


Met Leu Ser Lys Leu Pro Ser Glu Thr Val Gly Glu Ser Leu Glu Arg 
            500                 505                 510         


Asn Arg Leu Cys Asp Ala Val Asn Val Leu Leu Ser Leu Gln Asn Asp 
        515                 520                 525             


Asn Gly Gly Phe Ala Ser Tyr Glu Leu Thr Arg Ser Tyr Pro Trp Leu 
    530                 535                 540                 


Glu Leu Ile Asn Pro Ala Glu Thr Phe Gly Asp Ile Val Ile Asp Tyr 
545                 550                 555                 560 


Pro Tyr Val Glu Cys Thr Ser Ala Thr Met Glu Ala Leu Thr Leu Phe 
                565                 570                 575     


Lys Lys Leu His Pro Gly His Arg Thr Lys Glu Ile Asp Thr Ala Ile 
            580                 585                 590         


Val Arg Ala Ala Asn Phe Leu Glu Asn Met Gln Arg Thr Asp Gly Ser 
        595                 600                 605             


Trp Tyr Gly Cys Trp Gly Val Cys Phe Thr Tyr Ala Gly Trp Phe Gly 
    610                 615                 620                 


Ile Lys Gly Leu Val Ala Ala Gly Arg Thr Tyr Asn Asn Cys Leu Ala 
625                 630                 635                 640 


Ile Arg Lys Ala Cys Asp Phe Leu Leu Ser Lys Glu Leu Pro Gly Gly 
                645                 650                 655     


Gly Trp Gly Glu Ser Tyr Leu Ser Cys Gln Asn Lys Val Tyr Thr Asn 
            660                 665                 670         


Leu Glu Gly Asn Arg Pro His Leu Val Asn Thr Ala Trp Val Leu Met 
        675                 680                 685             


Ala Leu Ile Glu Ala Gly Gln Ala Glu Arg Asp Pro Thr Pro Leu His 
    690                 695                 700                 


Arg Ala Ala Arg Leu Leu Ile Asn Ser Gln Leu Glu Asn Gly Asp Phe 
705                 710                 715                 720 


Pro Gln Gln Glu Ile Met Gly Val Phe Asn Lys Asn Cys Met Ile Thr 
                725                 730                 735     


Tyr Ala Ala Tyr Arg Asn Ile Phe Pro Ile Trp Ala Leu Gly Glu Tyr 
            740                 745                 750         


Cys His Arg Val Leu Thr Glu 
        755                 


<210>  46
<211>  524
<212>  PRT
<213>  Cucumis melo

<400>  46

Met Val Asp Gln Cys Ala Leu Gly Trp Ile Leu Ala Ser Val Leu Gly 
1               5                   10                  15      


Ala Ser Ala Leu Tyr Leu Leu Phe Gly Lys Lys Asn Cys Gly Val Leu 
            20                  25                  30          


Asn Glu Arg Arg Arg Glu Ser Leu Lys Asn Ile Ala Thr Thr Asn Gly 
        35                  40                  45              


Glu Cys Lys Ser Ser Asn Ser Asp Gly Asp Ile Ile Ile Val Gly Ala 
    50                  55                  60                  


Gly Val Ala Gly Ser Ala Leu Ala Tyr Thr Leu Ala Lys Asp Gly Arg 
65                  70                  75                  80  


Gln Val His Val Ile Glu Arg Asp Leu Ser Glu Pro Asp Arg Ile Val 
                85                  90                  95      


Gly Glu Leu Leu Gln Pro Gly Gly Tyr Leu Lys Leu Thr Glu Leu Gly 
            100                 105                 110         


Leu Glu Asp Cys Val Asp Asp Ile Asp Ala Gln Arg Val Tyr Gly Tyr 
        115                 120                 125             


Ala Leu Phe Lys Asp Gly Lys Asp Thr Arg Leu Ser Tyr Pro Leu Glu 
    130                 135                 140                 


Lys Phe His Ser Asp Val Ser Gly Arg Ser Phe His Asn Gly Arg Phe 
145                 150                 155                 160 


Ile Gln Arg Met Arg Glu Lys Ala Ala Ser Leu Pro Asn Val Arg Leu 
                165                 170                 175     


Glu Gln Gly Thr Val Thr Ser Leu Leu Glu Glu Asn Gly Thr Ile Lys 
            180                 185                 190         


Gly Val Gln Tyr Lys Asn Lys Ser Gly Gln Glu Met Thr Ala Tyr Ala 
        195                 200                 205             


Pro Leu Thr Ile Val Cys Asp Gly Cys Phe Ser Asn Leu Arg Arg Ser 
    210                 215                 220                 


Leu Cys Asn Pro Lys Val Asp Val Pro Ser Cys Phe Val Gly Leu Ile 
225                 230                 235                 240 


Leu Glu Asn Cys Asp Leu Pro Tyr Ala Asn His Gly His Val Ile Leu 
                245                 250                 255     


Ala Asp Pro Ser Pro Ile Leu Phe Tyr Pro Ile Ser Ser Thr Glu Ile 
            260                 265                 270         


Arg Cys Leu Val Asp Val Pro Gly Gln Lys Val Pro Ser Ile Ser Asn 
        275                 280                 285             


Gly Glu Met Ala Asn Tyr Leu Lys Asn Val Val Ala Pro Gln Ile Pro 
    290                 295                 300                 


Pro Gln Leu Tyr Asn Ser Phe Ile Ala Ala Ile Asp Lys Gly Asn Ile 
305                 310                 315                 320 


Arg Thr Met Pro Asn Arg Ser Met Pro Ala Asp Pro Tyr Pro Thr Pro 
                325                 330                 335     


Gly Ala Leu Leu Met Gly Asp Ala Phe Asn Met Arg His Pro Leu Thr 
            340                 345                 350         


Gly Gly Gly Met Thr Val Ala Leu Ser Asp Ile Val Val Leu Arg Asp 
        355                 360                 365             


Leu Leu Lys Pro Leu Arg Asp Leu Asn Asp Ala Pro Thr Leu Cys Lys 
    370                 375                 380                 


Tyr Leu Glu Ala Phe Tyr Thr Leu Arg Lys Pro Val Ala Ser Thr Ile 
385                 390                 395                 400 


Asn Thr Leu Ala Gly Ala Leu Tyr Lys Val Phe Cys Ala Ser Pro Asp 
                405                 410                 415     


Gln Ala Arg Lys Glu Met Arg Gln Ala Cys Phe Asp Tyr Leu Ser Leu 
            420                 425                 430         


Gly Gly Ile Phe Ser Asn Gly Pro Val Ser Leu Leu Ser Gly Leu Asn 
        435                 440                 445             


Pro Arg Pro Leu Ser Leu Val Leu His Phe Phe Ala Val Ala Ile Tyr 
    450                 455                 460                 


Gly Val Gly Arg Leu Leu Ile Pro Phe Pro Ser Pro Lys Arg Val Trp 
465                 470                 475                 480 


Ile Gly Ala Arg Leu Ile Ser Gly Ala Ser Ala Ile Ile Phe Pro Ile 
                485                 490                 495     


Ile Lys Ala Glu Gly Val Arg Gln Met Phe Phe Pro Lys Thr Val Ala 
            500                 505                 510         


Ala Tyr Tyr Arg Ala Pro Pro Val Val Arg Glu Arg 
        515                 520                 


<210>  47
<211>  528
<212>  PRT
<213>  Cucumis sativus

<400>  47

Met Val Asp His Cys Thr Phe Gly Trp Ile Phe Ser Ala Phe Leu Ala 
1               5                   10                  15      


Phe Val Ile Ala Phe Ser Phe Phe Leu Ser Pro Arg Lys Asn Arg Arg 
            20                  25                  30          


Gly Arg Gly Thr Asn Ser Thr Pro Arg Arg Asp Cys Leu Ser Ser Ser 
        35                  40                  45              


Ala Thr Thr Asn Gly Glu Cys Arg Ser Val Asp Gly Asp Ala Asp Val 
    50                  55                  60                  


Ile Ile Val Gly Ala Gly Val Ala Gly Ser Ala Leu Ala His Thr Leu 
65                  70                  75                  80  


Gly Lys Asp Gly Arg Arg Val His Val Ile Glu Arg Asp Leu Thr Glu 
                85                  90                  95      


Pro Asp Arg Ile Val Gly Glu Leu Leu Gln Pro Gly Gly Tyr Leu Lys 
            100                 105                 110         


Leu Ile Glu Leu Gly Leu Gln Asp Cys Val Glu Glu Ile Asp Ala Gln 
        115                 120                 125             


Lys Val Tyr Gly Tyr Ala Leu Phe Lys Asp Gly Lys Ser Thr Arg Leu 
    130                 135                 140                 


Ser Tyr Pro Leu Glu Asn Phe Gln Ser Asp Val Ser Gly Arg Ser Phe 
145                 150                 155                 160 


His Asn Gly Arg Phe Ile Gln Arg Met Arg Glu Lys Ala Ala Phe Leu 
                165                 170                 175     


Pro Asn Val Arg Leu Glu Gln Gly Thr Val Thr Ser Leu Leu Glu Glu 
            180                 185                 190         


Lys Gly Thr Ile Thr Gly Val Gln Tyr Lys Ser Lys Asn Gly Glu Gln 
        195                 200                 205             


Lys Thr Ala Tyr Ala Pro Leu Thr Ile Val Cys Asp Gly Cys Phe Ser 
    210                 215                 220                 


Asn Leu Arg Arg Ser Leu Cys Asn Pro Met Val Asp Val Pro Ser Cys 
225                 230                 235                 240 


Phe Val Gly Leu Val Leu Glu Asn Cys Gln Leu Pro Tyr Ala Asn Leu 
                245                 250                 255     


Gly His Val Val Leu Gly Asp Pro Ser Pro Ile Leu Phe Tyr Pro Ile 
            260                 265                 270         


Ser Ser Thr Glu Ile Arg Cys Leu Val Asp Val Pro Gly Gln Lys Val 
        275                 280                 285             


Pro Ser Ile Ser Asn Gly Glu Met Glu Lys Tyr Leu Lys Thr Val Val 
    290                 295                 300                 


Ala Pro Gln Val Pro Pro Gln Ile His Asp Ala Phe Ile Ala Ala Ile 
305                 310                 315                 320 


Glu Lys Gly Asn Ile Arg Thr Met Pro Asn Arg Ser Met Pro Ala Ala 
                325                 330                 335     


Pro Gln Pro Thr Pro Gly Ala Leu Leu Met Gly Asp Ala Phe Asn Met 
            340                 345                 350         


Arg His Pro Leu Thr Gly Gly Gly Met Thr Val Ala Leu Ser Asp Ile 
        355                 360                 365             


Val Val Leu Arg Asn Leu Leu Lys Pro Leu Lys Asp Leu Asn Asp Ala 
    370                 375                 380                 


Pro Thr Leu Cys Lys Tyr Leu Glu Ser Phe Tyr Thr Leu Arg Lys Pro 
385                 390                 395                 400 


Val Ala Ser Thr Ile Asn Thr Leu Ala Gly Ala Leu Tyr Lys Val Phe 
                405                 410                 415     


Cys Ala Ser Ser Asp Gln Ala Arg Lys Glu Met Arg Gln Ala Cys Phe 
            420                 425                 430         


Asp Tyr Leu Ser Leu Gly Gly Ile Phe Ser Asn Gly Pro Val Ser Leu 
        435                 440                 445             


Leu Ser Gly Leu Asn Pro Arg Pro Leu Ser Leu Val Leu His Phe Phe 
    450                 455                 460                 


Ala Val Ala Ile Tyr Gly Val Gly Arg Leu Leu Leu Pro Phe Pro Ser 
465                 470                 475                 480 


Pro Lys Gly Ile Trp Ile Gly Ala Arg Leu Val Tyr Ser Ala Ser Gly 
                485                 490                 495     


Ile Ile Phe Pro Ile Ile Lys Ala Glu Gly Val Arg Gln Met Phe Phe 
            500                 505                 510         


Pro Ala Thr Val Pro Ala Tyr Tyr Arg Thr Pro Pro Val Phe Asn Ser 
        515                 520                 525             


<210>  48
<211>  318
<212>  PRT
<213>  Cucumis sativus

<400>  48

Met Glu Thr Ile Asn His Ile Thr Val Gln Thr Asn Gly Ile Asn Leu 
1               5                   10                  15      


His Val Ala Thr Ala Gly Pro Val Thr Gly Pro Pro Val Leu Leu Leu 
            20                  25                  30          


His Gly Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Ile Ile Phe 
        35                  40                  45              


Leu Ser Ser Val Gly Tyr Arg Val Ile Ala Pro Asp Leu Arg Gly Tyr 
    50                  55                  60                  


Gly Asp Ser Asp Ala Pro Pro Ser Ser Asp Thr Tyr Thr Ala Leu His 
65                  70                  75                  80  


Ile Val Gly Asp Val Val Gly Leu Leu Asn Glu Leu Gly Ile Asp Lys 
                85                  90                  95      


Val Leu Leu Val Gly His Asp Trp Gly Ala Leu Ile Ala Trp Tyr Phe 
            100                 105                 110         


Cys Leu Phe Arg Pro Asp Arg Ile Lys Ala Ser Val Ile Leu Ser Val 
        115                 120                 125             


Gln Phe Phe Pro Arg Asn Pro Lys Val Ser Phe Val Glu Gly Phe Lys 
    130                 135                 140                 


Ala Val Leu Gly Asp Gln Phe Tyr Met Val Arg Phe Gln Glu Pro Gly 
145                 150                 155                 160 


Lys Ala Glu Lys Glu Phe Ala Ser Val Asp Ile Arg Glu Phe Phe Lys 
                165                 170                 175     


Asn Val Met Ser Asn Arg Asp Pro Ser Ala Pro Tyr Leu Pro Gly Glu 
            180                 185                 190         


Glu Lys Phe Glu Gly Val Pro Pro Pro Ser Leu Ala Pro Trp Leu Thr 
        195                 200                 205             


Pro Gln Asp Ile Asp Tyr Tyr Ala Gln Lys Phe Ser His Ser Gly Phe 
    210                 215                 220                 


Thr Gly Gly Leu Asn Tyr Tyr Arg Ala Phe Asp Arg Thr Trp Glu Leu 
225                 230                 235                 240 


Thr Ala Pro Trp Thr Ala Ala Glu Ile Lys Val Pro Val Lys Phe Ile 
                245                 250                 255     


Val Gly Asp Leu Asp Leu Thr Tyr His Phe Pro Gly Gly Gln Asp Tyr 
            260                 265                 270         


Ile Asn Gly Asp Ala Phe Arg Lys Asp Val Pro Gly Leu Glu Glu Val 
        275                 280                 285             


Ile Val Met Lys Asp Thr Ser His Phe Ile Asn Gln Glu Arg Pro Asp 
    290                 295                 300                 


Glu Ile Asn Cys His Ile His Asp Phe Phe Asn Lys Phe Cys 
305                 310                 315             


<210>  49
<211>  316
<212>  PRT
<213>  Cucumis melo

<400>  49

Met Asp Ala Ile Gln His Thr Thr Ile Lys Thr Asn Gly Ile Lys Met 
1               5                   10                  15      


His Ile Ala Ser Val Gly Asn Gly Pro Val Val Leu Leu Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Leu Leu Tyr Leu Ser 
        35                  40                  45              


Ser Val Gly Tyr Arg Ala Ile Ala Pro Asp Leu Arg Gly Tyr Gly Asp 
    50                  55                  60                  


Thr Asp Ser Pro Glu Ser His Thr Ser Tyr Thr Ala Leu His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Val Gly Ala Leu Asp Glu Leu Gly Ile Glu Lys Val Phe 
                85                  90                  95      


Leu Val Gly His Asp Trp Gly Ala Ile Ile Ala Trp Tyr Phe Cys Leu 
            100                 105                 110         


Phe Arg Pro Glu Arg Ile Lys Ala Leu Val Asn Leu Ser Val Gln Phe 
        115                 120                 125             


Phe Pro Arg Asn Pro Ala Ile Ser Phe Ile Gln Arg Phe Arg Ala Ala 
    130                 135                 140                 


Tyr Gly Asp Asp Phe Tyr Met Cys Arg Phe Gln Val Pro Gly Glu Ala 
145                 150                 155                 160 


Glu Ala Asp Phe Ala Cys Ile Asp Thr Ala Gln Leu Phe Lys Thr Thr 
                165                 170                 175     


Leu Ser Asn Arg Ser Thr Lys Ala Pro Cys Leu Pro Lys Glu Tyr Gly 
            180                 185                 190         


Phe Arg Ala Ile Pro Pro Pro Glu Asn Leu Pro Ser Trp Leu Thr Glu 
        195                 200                 205             


Glu Asp Ile Asn Tyr Tyr Ala Ala Lys Phe Lys Glu Thr Gly Phe Thr 
    210                 215                 220                 


Gly Ala Leu Asn Tyr Tyr Arg Ala Phe Asp Leu Thr Trp Glu Leu Thr 
225                 230                 235                 240 


Ala Pro Trp Thr Gly Val Gln Ile Gln Val Pro Val Lys Phe Ile Val 
                245                 250                 255     


Gly Asp Ser Asp Leu Thr Tyr His Phe Lys Gly Ala Lys Glu Tyr Ile 
            260                 265                 270         


His Glu Gly Gly Phe Lys Arg Asp Val Pro Leu Leu Glu Glu Val Val 
        275                 280                 285             


Ile Val Glu Asn Ala Gly His Phe Val His Glu Glu Lys Pro His Glu 
    290                 295                 300                 


Ile Asn Thr His Ile His Asp Phe Ile Lys Lys Phe 
305                 310                 315     


<210>  50
<211>  315
<212>  PRT
<213>  Cucumis melo

<400>  50

Met Asp Lys Ile Gln His Ser Thr Ile Ser Thr Asn Gly Ile Asn Ile 
1               5                   10                  15      


His Phe Ala Ser Ile Gly Ser Gly Pro Val Val Leu Phe Leu His Gly 
            20                  25                  30          


Phe Pro Glu Leu Trp Tyr Ser Trp Arg His Gln Leu Leu Phe Leu Ala 
        35                  40                  45              


Ser Lys Gly Phe Arg Ala Ile Ala Pro Asp Leu Arg Gly Phe Gly Asp 
    50                  55                  60                  


Ser Asp Ala Pro Pro Ser Pro Ser Ser Tyr Thr Pro His His Ile Val 
65                  70                  75                  80  


Gly Asp Leu Ile Gly Leu Leu Asp His Leu Gly Ile Asp Gln Val Phe 
                85                  90                  95      


Leu Val Gly His Asp Trp Gly Ala Met Met Ala Trp Tyr Phe Cys Leu 
            100                 105                 110         


Phe Arg Pro Asp Arg Val Lys Ala Leu Val Asn Leu Ser Val His Tyr 
        115                 120                 125             


Thr Pro Arg Asn Pro Ala Gly Ser Pro Leu Ala Val Thr Arg Arg Tyr 
    130                 135                 140                 


Leu Gly Asp Asp Phe Tyr Ile Cys Lys Phe Gln Glu Pro Gly Val Ala 
145                 150                 155                 160 


Glu Ala Asp Phe Gly Ser Val Asp Thr Ala Thr Met Met Lys Lys Phe 
                165                 170                 175     


Leu Thr Met Arg Asp Pro Arg Pro Ala Ile Ile Pro Asn Gly Phe Lys 
            180                 185                 190         


Thr Leu Leu Glu Thr Pro Glu Ile Leu Pro Ser Trp Leu Thr Glu Glu 
        195                 200                 205             


Asp Ile Glu Tyr Phe Ala Ser Lys Phe Ser Lys Thr Gly Phe Thr Gly 
    210                 215                 220                 


Gly Phe Asn Tyr Tyr Arg Ala Leu Asp Ile Thr Trp Glu Leu Thr Gly 
225                 230                 235                 240 


Pro Trp Ser Arg Ala Gln Ile Lys Val Pro Thr Lys Phe Ile Val Gly 
                245                 250                 255     


Asp Leu Asp Leu Val Tyr Asn Phe Pro Gly Ala Lys Glu Tyr Ile His 
            260                 265                 270         


Gly Gly Gly Phe Lys Lys Asp Val Pro Leu Leu Glu Asp Val Val Val 
        275                 280                 285             


Ile Glu Gly Ala Ala His Phe Ile Asn Gln Glu Lys Pro Asp Glu Ile 
    290                 295                 300                 


Ser Ser Leu Ile Tyr Asp Phe Ile Thr Lys Phe 
305                 310                 315 


<210>  51
<211>  322
<212>  PRT
<213>  Cucumis sativus

<400>  51

Met Glu Lys Ile Glu His Thr Thr Ile Pro Thr Asn Gly Ile Asn Met 
1               5                   10                  15      


His Val Ala Ser Ile Gly Ser Gly Pro Ala Val Leu Phe Leu His Gly 
            20                  25                  30          


Phe Pro Gln Leu Trp Tyr Ser Trp Arg His Gln Leu Leu Phe Leu Ala 
        35                  40                  45              


Ser Lys Gly Phe Arg Ala Leu Ala Pro Asp Leu Arg Gly Phe Gly Asp 
    50                  55                  60                  


Thr Asp Ala Pro Pro Ser Pro Ser Ser Tyr Thr Phe His His Ile Ile 
65                  70                  75                  80  


Gly Asp Leu Ile Gly Leu Leu Asp His Phe Gly Leu Asp Lys Val Phe 
                85                  90                  95      


Leu Val Gly His Asp Trp Gly Ala Val Ile Ala Trp Tyr Phe Cys Leu 
            100                 105                 110         


Phe Arg Pro Asp Arg Val Lys Ala Leu Val Asn Leu Ser Val His Tyr 
        115                 120                 125             


Leu Lys Arg His Pro Ser Ile Asn Phe Val Asp Gly Phe Arg Ala Ser 
    130                 135                 140                 


Ala Gly Glu Asn Phe Tyr Ile Cys Gln Phe Gln Glu Ala Gly Val Ala 
145                 150                 155                 160 


Glu Ala Asp Phe Gly Ser Val Asp Thr Ala Thr Met Met Lys Lys Phe 
                165                 170                 175     


Met Gly Met Arg Asp Pro Val Ala Pro Pro Ile Tyr Asn Thr Lys Glu 
            180                 185                 190         


Lys Gly Phe Ser Ser Leu Glu Thr Pro Asn Pro Leu Pro Cys Trp Leu 
        195                 200                 205             


Thr Glu Glu Asp Val Asp Phe Phe Ala Ser Lys Phe Ser Lys Thr Gly 
    210                 215                 220                 


Phe Thr Gly Gly Phe Asn Tyr Tyr Arg Ala Leu Asn Leu Ser Trp Glu 
225                 230                 235                 240 


Leu Thr Ala Ala Trp Asn Gly Ser Lys Ile Glu Val Pro Val Lys Phe 
                245                 250                 255     


Ile Val Gly Asp Leu Asp Leu Val Tyr His Phe Pro Gly Ala Lys Glu 
            260                 265                 270         


Tyr Ile Asn Gly Gly Glu Phe Lys Lys Asp Val Pro Phe Leu Glu Glu 
        275                 280                 285             


Val Val Val Ile Lys Asp Ala Ala His Phe Ile Asn Gln Glu Lys Pro 
    290                 295                 300                 


His Gln Ile Asn Ser Leu Ile Tyr His Phe Ile Asn Lys Phe Val Ser 
305                 310                 315                 320 


Ser Ile 
        


<210>  52
<211>  473
<212>  PRT
<213>  Siraitia grosvenorii

<400>  52

Met Trp Thr Val Val Leu Gly Leu Ala Thr Leu Phe Val Ala Tyr Tyr 
1               5                   10                  15      


Ile His Trp Ile Asn Lys Trp Arg Asp Ser Lys Phe Asn Gly Val Leu 
            20                  25                  30          


Pro Pro Gly Thr Met Gly Leu Pro Leu Ile Gly Glu Thr Ile Gln Leu 
        35                  40                  45              


Ser Arg Pro Ser Asp Ser Leu Asp Val His Pro Phe Ile Gln Lys Lys 
    50                  55                  60                  


Val Glu Arg Tyr Gly Pro Ile Phe Lys Thr Cys Leu Ala Gly Arg Pro 
65                  70                  75                  80  


Val Val Val Ser Ala Asp Ala Glu Phe Asn Asn Tyr Ile Met Leu Gln 
                85                  90                  95      


Glu Gly Arg Ala Val Glu Met Trp Tyr Leu Asp Thr Leu Ser Lys Phe 
            100                 105                 110         


Phe Gly Leu Asp Thr Glu Trp Leu Lys Ala Leu Gly Leu Ile His Lys 
        115                 120                 125             


Tyr Ile Arg Ser Ile Thr Leu Asn His Phe Gly Ala Glu Ala Leu Arg 
    130                 135                 140                 


Glu Arg Phe Leu Pro Phe Ile Glu Ala Ser Ser Met Glu Ala Leu His 
145                 150                 155                 160 


Ser Trp Ser Thr Gln Pro Ser Val Glu Val Lys Asn Ala Ser Ala Leu 
                165                 170                 175     


Met Val Phe Arg Thr Ser Val Asn Lys Met Phe Gly Glu Asp Ala Lys 
            180                 185                 190         


Lys Leu Ser Gly Asn Ile Pro Gly Lys Phe Thr Lys Leu Leu Gly Gly 
        195                 200                 205             


Phe Leu Ser Leu Pro Leu Asn Phe Pro Gly Thr Thr Tyr His Lys Cys 
    210                 215                 220                 


Leu Lys Asp Met Lys Glu Ile Gln Lys Lys Leu Arg Glu Val Val Asp 
225                 230                 235                 240 


Asp Arg Leu Ala Asn Val Gly Pro Asp Val Glu Asp Phe Leu Gly Gln 
                245                 250                 255     


Ala Leu Lys Asp Lys Glu Ser Glu Lys Phe Ile Ser Glu Glu Phe Ile 
            260                 265                 270         


Ile Gln Leu Leu Phe Ser Ile Ser Phe Ala Ser Phe Glu Ser Ile Ser 
        275                 280                 285             


Thr Thr Leu Thr Leu Ile Leu Lys Leu Leu Asp Glu His Pro Glu Val 
    290                 295                 300                 


Val Lys Glu Leu Glu Ala Glu His Glu Ala Ile Arg Lys Ala Arg Ala 
305                 310                 315                 320 


Asp Pro Asp Gly Pro Ile Thr Trp Glu Glu Tyr Lys Ser Met Thr Phe 
                325                 330                 335     


Thr Leu Gln Val Ile Asn Glu Thr Leu Arg Leu Gly Ser Val Thr Pro 
            340                 345                 350         


Ala Leu Leu Arg Lys Thr Val Lys Asp Leu Gln Val Lys Gly Tyr Ile 
        355                 360                 365             


Ile Pro Glu Gly Trp Thr Ile Met Leu Val Thr Ala Ser Arg His Arg 
    370                 375                 380                 


Asp Pro Lys Val Tyr Lys Asp Pro His Ile Phe Asn Pro Trp Arg Trp 
385                 390                 395                 400 


Lys Asp Leu Asp Ser Ile Thr Ile Gln Lys Asn Phe Met Pro Phe Gly 
                405                 410                 415     


Gly Gly Leu Arg His Cys Ala Gly Ala Glu Tyr Ser Lys Val Tyr Leu 
            420                 425                 430         


Cys Thr Phe Leu His Ile Leu Cys Thr Lys Tyr Arg Trp Thr Lys Leu 
        435                 440                 445             


Gly Gly Gly Thr Ile Ala Arg Ala His Ile Leu Ser Phe Glu Asp Gly 
    450                 455                 460                 


Leu His Val Lys Phe Thr Pro Lys Glu 
465                 470             


<210>  53
<211>  480
<212>  PRT
<213>  Cucumis melo

<400>  53

Met Ala Ser Thr His Ile Leu Leu Phe Pro Phe Met Ala Gln Gly His 
1               5                   10                  15      


Met Ile Pro Met Ile Asp Leu Ala Lys Leu Leu Ala His His Gly Phe 
            20                  25                  30          


Ile Ile Thr Ile Val Thr Thr Pro His Asn Ala Asp Arg Tyr His Ser 
        35                  40                  45              


Val Leu Ala Arg Ala Thr His Ser Gly Leu Gln Ile His Val Ala Leu 
    50                  55                  60                  


Leu Pro Phe Pro Ser Thr Gln Val Gly Leu Pro Glu Gly Cys Glu Asn 
65                  70                  75                  80  


Leu Asp Leu Leu Pro Leu His Leu Ser Ser Ser Met Ser Ala Phe Cys 
                85                  90                  95      


Arg Ala Thr Ser Leu Leu Tyr Glu Pro Ser Glu Lys Leu Leu Gln Gln 
            100                 105                 110         


Leu Cys Pro Arg Pro Ser Cys Ile Ile Ser Asp Met Cys Leu Pro Trp 
        115                 120                 125             


Thr Leu Arg Leu Ala Gln Asn His Gln Ile Pro Arg Leu Val Phe Tyr 
    130                 135                 140                 


Ser Leu Ser Cys Phe Phe Leu Leu Cys Met Arg Ser Leu Lys Thr Asn 
145                 150                 155                 160 


His Ser Leu Val Thr Ser Ile Ser Asp Ser Glu Phe Leu Thr Leu Ser 
                165                 170                 175     


Asp Leu Pro Asp Pro Val Glu Ile Arg Lys Ser Gln Leu Ser Arg Val 
            180                 185                 190         


Lys Asn Glu Glu Met Gly Lys Leu Ser Tyr Glu Met Val Glu Ala Asp 
        195                 200                 205             


Arg Leu Ser His Gly Val Ile Leu Asn Val Phe Glu Glu Met Glu Ala 
    210                 215                 220                 


Glu Tyr Val Ala Glu Tyr Arg Lys Asn Arg Asp Leu Pro Gln Lys Val 
225                 230                 235                 240 


Trp Cys Val Gly Pro Leu Ser Leu Cys Asn Asp Asn Lys Leu Asp Lys 
                245                 250                 255     


Ala Glu Arg Gly Glu Lys Ser Ser Ile His Glu Asp Glu Cys Ile Lys 
            260                 265                 270         


Trp Leu Asn Gly Gln Gln Pro Ser Ser Val Val Tyr Val Ser Met Gly 
        275                 280                 285             


Ser Leu Cys Asn Leu Ser Thr Pro Gln Leu Val Glu Leu Gly Leu Gly 
    290                 295                 300                 


Leu Glu Ala Ser Lys Lys Pro Phe Ile Trp Val Ile Arg Lys Gly Asn 
305                 310                 315                 320 


Leu Thr Glu Glu Leu Gln Arg Trp Ile Met Glu Tyr Asp Phe Glu Arg 
                325                 330                 335     


Lys Thr Glu Gly Trp Gly Leu Val Ile Arg Gly Trp Ala Pro Gln Val 
            340                 345                 350         


Ala Ile Leu Ser His Ser Ala Ile Gly Gly Phe Leu Thr His Cys Gly 
        355                 360                 365             


Trp Asn Ser Ser Ile Glu Gly Ile Ala Ala Gly Val Pro Met Met Thr 
    370                 375                 380                 


Trp Pro Leu Phe Ala Asp Gln Val Phe Asn Ala Lys Leu Ile Val Glu 
385                 390                 395                 400 


Val Leu Lys Val Gly Val Ser Val Gly Glu Glu Thr Ala Leu His Trp 
                405                 410                 415     


Gly Glu Glu Ala Glu Lys Glu Val Met Val Lys Arg Glu Glu Val Arg 
            420                 425                 430         


Glu Ala Ile Glu Arg Val Met Asp Gly Glu Asn Arg Glu Glu Met Lys 
        435                 440                 445             


Gln Arg Ser Lys Lys Leu Ala Glu Met Ala Lys Arg Ala Val Glu Glu 
    450                 455                 460                 


Gly Gly Ser Ser His Arg Asn Leu Lys Arg Leu Ile Glu Glu Ile Val 
465                 470                 475                 480 


<210>  54
<211>  497
<212>  PRT
<213>  Cucumis melo

<400>  54

Met Ala Ser Thr Leu Ser Asn Gln Leu Glu Leu Gln Pro His Phe Val 
1               5                   10                  15      


Leu Val Pro Leu Met Ala Gln Gly His Met Ile Pro Met Ile Asp Ile 
            20                  25                  30          


Ala Thr Leu Leu Ala Arg Arg Gly Val Phe Val Thr Phe Val Thr Thr 
        35                  40                  45              


Pro Tyr Asn Ala Thr Arg Leu Glu Ser Phe Phe Ala Arg Ala Lys Gln 
    50                  55                  60                  


Ser Ser Leu Ser Ile Ser Leu Leu Glu Ile Pro Phe Pro Cys Leu Gln 
65                  70                  75                  80  


Val Gly Leu Pro Leu Gly Cys Glu Asn Leu Asp Thr Leu Pro Ser Arg 
                85                  90                  95      


Ser Leu Leu Arg Asn Phe Tyr Lys Ala Leu Ser Leu Leu Gln Gln Pro 
            100                 105                 110         


Leu Glu Gln Phe Leu Ser Arg His His Leu Asn Pro Thr Cys Ile Ile 
        115                 120                 125             


Ser Asp Lys Tyr Leu Tyr Trp Thr Ala Gln Thr Ala His Lys Phe Lys 
    130                 135                 140                 


Cys Pro Arg Val Val Phe His Gly Thr Gly Cys Phe Ser Leu Leu Ser 
145                 150                 155                 160 


Ser His Asn Leu Gln Leu Tyr Ser Pro His Thr Ser Ile Asp Ser Asn 
                165                 170                 175     


Ser Gln Pro Phe Leu Val Pro Gly Leu Pro His Lys Ile Glu Ile Thr 
            180                 185                 190         


Lys Ser Gln Leu Pro Gly Ser Leu Ile Lys Ser Pro Asp Phe Asp Asp 
        195                 200                 205             


Phe Arg Asp Lys Ile Thr Lys Ala Glu Gln Glu Ala Tyr Gly Val Val 
    210                 215                 220                 


Val Asn Ser Phe Ser Glu Leu Glu Asn Gly Tyr Tyr Gln Asn Tyr Glu 
225                 230                 235                 240 


Arg Ala Ile Ser Lys Lys Leu Trp Cys Ile Gly Pro Val Ser Leu Cys 
                245                 250                 255     


Asn Glu Asn Ser Ile Glu Lys Tyr Asn Arg Gly Asn Lys Ala Ser Ile 
            260                 265                 270         


Glu Gln Ser Asn Cys Leu Asn Trp Leu Asp Ser Met Ile Pro Lys Ser 
        275                 280                 285             


Val Leu Tyr Ile Cys Leu Gly Ser Leu Cys Arg Met Leu Pro Ser Gln 
    290                 295                 300                 


Leu Ile Gln Leu Gly Gln Cys Leu Glu Ser Ser Thr Arg Pro Phe Ile 
305                 310                 315                 320 


Trp Val Ile Lys Asn Arg Asp Glu Asn Cys Ser Glu Leu Glu Lys Trp 
                325                 330                 335     


Leu Ser Glu Glu Glu Phe Glu Arg Lys Thr Lys Gly Arg Gly Leu Ile 
            340                 345                 350         


Ile Arg Gly Trp Ala Pro Gln Leu Leu Ile Leu Ser His Trp Ser Thr 
        355                 360                 365             


Gly Gly Phe Leu Thr His Cys Gly Trp Asn Ser Thr Val Glu Gly Ile 
    370                 375                 380                 


Gly Asn Gly Val Pro Met Ile Thr Trp Pro Gln Phe Ala Glu Gln Phe 
385                 390                 395                 400 


Leu Asn Glu Lys Leu Val Val Glu Ile Leu Lys Ile Gly Val Arg Val 
                405                 410                 415     


Gly Val Glu Gly Ala Val Arg Trp Gly Glu Glu Glu Arg Val Gly Val 
            420                 425                 430         


Met Ala Lys Lys Glu Glu Ile Glu Lys Ala Ile Glu Met Val Met Asp 
        435                 440                 445             


Gly Gly Glu Glu Gly Glu Glu Arg Arg Arg Arg Val Gly Asp Leu Ser 
    450                 455                 460                 


Lys Met Ala Pro Lys Ala Met Glu Asn Gly Gly Ser Ser Tyr Val Asn 
465                 470                 475                 480 


Leu Ser Leu Phe Ile Glu Asp Val Met Ala Gln Ser Ala His Leu Lys 
                485                 490                 495     


Ala 
    


<210>  55
<211>  477
<212>  PRT
<213>  Cucumis sativus

<400>  55

Met Asp Pro Lys Asn Thr Gln Leu Arg Ile Phe Phe Phe Pro Phe Met 
1               5                   10                  15      


Ala Gln Gly His Thr Ile Pro Ala Ile Asp Met Ala Lys Leu Phe Ala 
            20                  25                  30          


Ser Arg Gly Ala Asp Val Ala Ile Ile Thr Thr Pro Leu Asn Ala Pro 
        35                  40                  45              


Leu Ile Ala Lys Ser Ile Asn Lys Phe Asp Arg Pro Gly Arg Lys Ile 
    50                  55                  60                  


Glu Leu Leu Ile Ile Asp Phe Pro Ser Val Ala Val Gly Leu Pro Asp 
65                  70                  75                  80  


Gly Cys Glu Ser Leu Asp Leu Ala Arg Ser Pro Glu Met Phe Gln Ser 
                85                  90                  95      


Phe Phe Arg Ala Thr Thr Leu Leu Glu Pro Gln Ile Asp Gln Ile Leu 
            100                 105                 110         


Asp His His Arg Pro His Cys Leu Val Ala Asp Thr Phe Phe Pro Trp 
        115                 120                 125             


Thr Thr Asp Leu Ala Ala Lys Tyr Gly Ile Pro Arg Val Val Phe His 
    130                 135                 140                 


Gly Thr Cys Phe Phe Ala Leu Cys Ala Ala Ala Ser Leu Ile Ala Asn 
145                 150                 155                 160 


Arg Pro Tyr Lys Lys Val Ser Ser Asp Leu Glu Pro Phe Val Ile Pro 
                165                 170                 175     


Gly Leu Pro Asp Glu Ile Lys Leu Thr Arg Ser Gln Val Pro Gly Phe 
            180                 185                 190         


Leu Lys Glu Glu Val Glu Thr Asp Phe Ile Lys Leu Tyr Trp Ala Ser 
        195                 200                 205             


Lys Glu Val Glu Ser Arg Cys Tyr Gly Phe Leu Ile Asn Ser Phe Tyr 
    210                 215                 220                 


Glu Leu Glu Pro Ala Tyr Ala Asp Tyr Tyr Arg Asn Val Leu Gly Arg 
225                 230                 235                 240 


Arg Ala Trp His Ile Gly Pro Leu Ser Leu Tyr Ser Asn Val Glu Glu 
                245                 250                 255     


Asp Asn Val Gln Arg Gly Ser Ser Ser Ser Ile Ser Glu Asp Gln Cys 
            260                 265                 270         


Leu Lys Trp Leu Asp Ser Lys Asn Pro Asp Ser Val Leu Tyr Val Ser 
        275                 280                 285             


Phe Gly Ser Leu Ala Ser Leu Thr Asn Ser Gln Leu Leu Glu Ile Ala 
    290                 295                 300                 


Lys Gly Leu Glu Gly Thr Gly Gln Asn Phe Ile Trp Val Val Lys Lys 
305                 310                 315                 320 


Ala Lys Gly Asp Gln Glu Glu Trp Leu Pro Glu Gly Phe Glu Lys Arg 
                325                 330                 335     


Val Glu Gly Lys Gly Leu Ile Ile Arg Gly Trp Ala Pro Gln Val Leu 
            340                 345                 350         


Ile Leu Asp His Arg Ser Ile Gly Gly Phe Val Thr His Cys Gly Trp 
        355                 360                 365             


Asn Ser Ala Leu Glu Gly Val Thr Ala Gly Val Pro Met Val Thr Trp 
    370                 375                 380                 


Pro Asn Ser Ala Glu Gln Phe Tyr Asn Glu Lys Leu Ile Thr Asp Val 
385                 390                 395                 400 


Leu Gln Ile Gly Val Gly Val Gly Ala Leu Tyr Trp Gly Arg Ala Gly 
                405                 410                 415     


Lys Asp Glu Ile Lys Ser Glu Ala Ile Glu Lys Ala Val Asn Arg Val 
            420                 425                 430         


Met Val Gly Glu Glu Ala Glu Glu Met Arg Ser Arg Ala Lys Ala Leu 
        435                 440                 445             


Gly Ile Gln Ala Arg Lys Ala Ile Val Glu Gly Gly Ser Ser Ser Ser 
    450                 455                 460                 


Asp Leu Asn Ala Phe Phe Lys Asp Leu Arg Ser Gln Ile 
465                 470                 475         


<210>  56
<211>  467
<212>  PRT
<213>  Cucumis melo

<400>  56

Met Glu Met Thr Ala Ala Asn Gly Gly Gly Glu Arg Ile Lys Gln Ser 
1               5                   10                  15      


His Val Ile Val Phe Pro Phe Pro Arg His Gly His Met Ser Pro Met 
            20                  25                  30          


Leu Gln Phe Ser Lys Arg Leu Ile Ser Lys Gly Leu Leu Leu Thr Phe 
        35                  40                  45              


Leu Ile Thr Ser Ser Ala Ser Gln Ser Leu Thr Ile Asn Ile Pro Pro 
    50                  55                  60                  


Ser Pro Ser Phe His Phe Lys Ile Ile Ser Asp Leu Pro Glu Ser Asp 
65                  70                  75                  80  


Asp Val Ala Thr Leu Asp Ala Tyr Leu Arg Ser Phe Arg Ala Ala Val 
                85                  90                  95      


Thr Lys Ser Leu Ser Asn Phe Ile Asp Glu Val Leu Thr Ser Ser Ser 
            100                 105                 110         


Asn Glu Glu Val Pro Pro Thr Leu Ile Val Tyr Asp Ser Val Met Pro 
        115                 120                 125             


Trp Val Gln Ser Val Ala Ala Glu Arg Gly Leu Asp Ser Ala Pro Phe 
    130                 135                 140                 


Phe Thr Glu Ser Ala Ala Val Asn His Leu Leu His Leu Val Tyr Gly 
145                 150                 155                 160 


Gly Ser Leu Ser Ile Pro Pro Pro Asp Asn Val Val Val Ser Leu Pro 
                165                 170                 175     


Ser Glu Ile Val Leu Gln Pro Glu Asp Leu Pro Ser Phe Pro Asp Asp 
            180                 185                 190         


Pro Glu Val Val Leu Asp Phe Met Thr Ser Gln Phe Ser His Leu Glu 
        195                 200                 205             


Asn Val Lys Trp Ile Phe Ile Asn Thr Phe Asp Arg Leu Glu Ser Lys 
    210                 215                 220                 


Val Val Asn Trp Met Ala Lys Thr Leu Pro Ile Lys Thr Val Gly Pro 
225                 230                 235                 240 


Thr Ile Pro Ser Ala Tyr Leu Asp Gly Arg Leu Glu Lys Asp Lys Ala 
                245                 250                 255     


Tyr Gly Leu Asn Val Ser Lys Ser Asn Asn Gly Lys Cys Pro Ile Lys 
            260                 265                 270         


Trp Leu Asp Ser Lys Glu Thr Ala Ser Val Ile Tyr Ile Ser Phe Gly 
        275                 280                 285             


Ser Leu Val Ile Leu Ser Glu Glu Gln Val Lys Glu Leu Thr Asn Leu 
    290                 295                 300                 


Leu Arg Asp Thr Asp Phe Ser Phe Leu Trp Val Leu Arg Glu Ser Glu 
305                 310                 315                 320 


Met Val Lys Leu Pro Lys Asn Phe Val Gln Asp Thr Ser Asp Arg Gly 
                325                 330                 335     


Leu Ile Val Asn Trp Cys Cys Gln Leu Gln Val Leu Ser His Lys Ala 
            340                 345                 350         


Val Ser Cys Phe Val Thr His Cys Gly Trp Asn Ser Thr Leu Glu Ala 
        355                 360                 365             


Leu Ser Leu Gly Val Pro Met Val Ala Ile Pro Gln Trp Ile Asp Gln 
    370                 375                 380                 


Thr Thr Asn Ala Lys Phe Val Ala Asp Val Trp Arg Val Gly Val Arg 
385                 390                 395                 400 


Val Lys Lys Asn Glu Lys Ser Val Ala Ile Lys Glu Glu Leu Glu Ala 
                405                 410                 415     


Ser Ile Arg Lys Ile Val Val Gln Gly Asn Gly Thr Asn Glu Phe Lys 
            420                 425                 430         


Gln Asn Ala Ile Lys Trp Lys Asn Leu Ala Lys Glu Ala Val Asp Glu 
        435                 440                 445             


Arg Gly Ser Ser Asp Lys Asn Ile Glu Glu Phe Val Gln Ala Leu Val 
    450                 455                 460                 


Ala Ser Asn 
465         


<210>  57
<211>  464
<212>  PRT
<213>  Cucumis sativus

<400>  57

Met Arg Asn His His Phe Leu Ile Val Cys Phe Pro Ser Gln Gly Tyr 
1               5                   10                  15      


Ile Asn Pro Ser Leu Gln Leu Ala Asn Lys Leu Thr Ser Leu Asn Ile 
            20                  25                  30          


Glu Val Thr Phe Ala Thr Thr Val Thr Ala Ser Arg Arg Met Lys Ile 
        35                  40                  45              


Thr Gln Gln Ile Ser Ser Pro Ser Thr Leu Ser Phe Ala Thr Phe Ser 
    50                  55                  60                  


Asp Gly Phe Asp Asp Glu Asn His Lys Thr Ser Asp Phe Asn His Phe 
65                  70                  75                  80  


Phe Ser Glu Leu Lys Arg Cys Gly Ser Gln Ser Leu Thr Asp Leu Ile 
                85                  90                  95      


Thr Ser Phe Arg Asp Arg His Arg Arg Pro Phe Thr Phe Val Ile Tyr 
            100                 105                 110         


Ser Leu Leu Leu Asn Trp Ala Ala Asp Val Ala Thr Ser Phe Asn Ile 
        115                 120                 125             


Pro Ser Ala Leu Phe Ser Ala Gln Pro Ala Thr Val Leu Ala Leu Tyr 
    130                 135                 140                 


Tyr Tyr Tyr Phe His Gly Phe Glu Asp Glu Ile Thr Asn Lys Leu Gln 
145                 150                 155                 160 


Asn Asp Gly Pro Ser Ser Leu Ser Ile Glu Leu Pro Gly Leu Pro Leu 
                165                 170                 175     


Leu Phe Lys Ser His Glu Met Pro Ser Phe Phe Ser Pro Ser Gly Gln 
            180                 185                 190         


His Ala Phe Ile Ile Pro Trp Met Arg Glu Gln Met Glu Phe Leu Gly 
        195                 200                 205             


Gln Gln Lys Gln Pro Ile Lys Val Leu Val Asn Thr Phe His Ala Leu 
    210                 215                 220                 


Glu Asn Glu Ala Leu Arg Ala Ile His Glu Leu Glu Met Ile Ala Ile 
225                 230                 235                 240 


Gly Pro Leu Ile Ser Gln Phe Arg Gly Asp Leu Phe Gln Val Ser Asn 
                245                 250                 255     


Glu Asp Tyr Tyr Met Glu Trp Leu Asn Ser Lys Ser Asn Cys Ser Val 
            260                 265                 270         


Val Tyr Leu Ser Phe Gly Ser Ile Cys Val Leu Ser Lys Glu Gln Glu 
        275                 280                 285             


Glu Glu Ile Leu Tyr Gly Leu Phe Glu Ser Gly Tyr Pro Phe Leu Trp 
    290                 295                 300                 


Val Met Arg Ser Lys Ser Asp Glu Asp Glu Glu Lys Trp Lys Glu Leu 
305                 310                 315                 320 


Val Glu Gly Lys Gly Lys Ile Val Ser Trp Cys Arg Gln Ile Glu Val 
                325                 330                 335     


Leu Lys His Pro Ser Leu Gly Cys Phe Met Ser His Cys Gly Trp Asn 
            340                 345                 350         


Ser Thr Leu Glu Ser Leu Ser Phe Gly Leu Pro Met Val Ala Phe Pro 
        355                 360                 365             


Gln Gln Val Asp Gln Pro Thr Asn Ala Lys Leu Val Glu Asp Val Trp 
    370                 375                 380                 


Lys Met Gly Val Arg Val Lys Gly Asn Leu Glu Gly Ile Val Glu Arg 
385                 390                 395                 400 


Glu Glu Ile Arg Arg Cys Leu Asp Leu Val Met Asn Arg Lys Tyr Ile 
                405                 410                 415     


Asn Gly Glu Arg Glu Glu Thr Glu Lys Asn Val Glu Lys Trp Lys Lys 
            420                 425                 430         


Leu Ala Trp Glu Ala Met Asp Glu Gly Gly Ser Ser Ile Leu Asn Leu 
        435                 440                 445             


Ala Asn Phe Val Asp Glu Ile Asp Val Gly Asp Glu Leu Ala Asp Ser 
    450                 455                 460                 


<210>  58
<211>  471
<212>  PRT
<213>  Cucumis sativus

<400>  58

Met Gly Leu Ser Pro Thr Asp His Val Leu Leu Phe Pro Phe Pro Ala 
1               5                   10                  15      


Lys Gly His Ile Lys Pro Phe Phe Cys Leu Ala His Leu Leu Cys Asn 
            20                  25                  30          


Ala Gly Leu Arg Val Thr Phe Leu Ser Thr Glu His His His Gln Lys 
        35                  40                  45              


Leu His Asn Leu Thr His Leu Ala Ala Gln Ile Pro Ser Leu His Phe 
    50                  55                  60                  


Gln Ser Ile Ser Asp Gly Leu Ser Leu Asp His Pro Arg Asn Leu Leu 
65                  70                  75                  80  


Asp Gly Gln Leu Phe Lys Ser Met Pro Gln Val Thr Lys Pro Leu Phe 
                85                  90                  95      


Arg Gln Leu Leu Leu Ser Tyr Lys Asp Gly Thr Ser Pro Ile Thr Cys 
            100                 105                 110         


Val Ile Thr Asp Leu Ile Leu Arg Phe Pro Met Asp Val Ala Gln Glu 
        115                 120                 125             


Leu Asp Ile Pro Val Phe Cys Phe Ser Thr Phe Ser Ala Arg Phe Leu 
    130                 135                 140                 


Phe Leu Tyr Phe Ser Ile Pro Lys Leu Leu Glu Asp Gly Gln Ile Pro 
145                 150                 155                 160 


Tyr Pro Glu Gly Asn Ser Asn Gln Val Leu His Gly Ile Pro Gly Ala 
                165                 170                 175     


Glu Gly Leu Leu Arg Cys Lys Asp Leu Pro Gly Tyr Trp Ser Val Glu 
            180                 185                 190         


Ala Val Ala Asn Tyr Asn Pro Met Asn Phe Val Asn Gln Thr Ile Ala 
        195                 200                 205             


Thr Ser Lys Ser His Gly Leu Ile Leu Asn Thr Phe Asp Glu Leu Glu 
    210                 215                 220                 


Val Pro Phe Ile Thr Asn Leu Ser Lys Ile Tyr Lys Lys Val Tyr Thr 
225                 230                 235                 240 


Ile Gly Pro Ile His Ser Leu Leu Lys Lys Ser Val Gln Thr Gln Tyr 
                245                 250                 255     


Glu Phe Trp Lys Glu Asp His Ser Cys Leu Ala Trp Leu Asp Ser Gln 
            260                 265                 270         


Pro Pro Arg Ser Val Met Phe Val Ser Phe Gly Ser Ile Val Lys Leu 
        275                 280                 285             


Lys Ser Ser Gln Leu Lys Glu Phe Trp Asn Gly Leu Val Asp Ser Gly 
    290                 295                 300                 


Lys Ala Phe Leu Leu Val Leu Arg Ser Asp Ala Leu Val Glu Glu Thr 
305                 310                 315                 320 


Gly Glu Glu Asp Glu Lys Gln Lys Glu Leu Val Ile Lys Glu Ile Met 
                325                 330                 335     


Glu Thr Lys Glu Glu Gly Arg Trp Val Ile Val Asn Trp Ala Pro Gln 
            340                 345                 350         


Glu Lys Val Leu Glu His Lys Ala Ile Gly Gly Phe Leu Thr His Ser 
        355                 360                 365             


Gly Trp Asn Ser Thr Leu Glu Ser Val Ala Val Gly Val Pro Met Val 
    370                 375                 380                 


Ser Trp Pro Gln Ile Gly Asp Gln Pro Ser Asn Ala Thr Trp Leu Ser 
385                 390                 395                 400 


Lys Val Trp Lys Ile Gly Val Glu Met Glu Asp Ser Tyr Asp Arg Ser 
                405                 410                 415     


Thr Val Glu Ser Lys Val Arg Ser Ile Met Glu His Glu Asp Lys Lys 
            420                 425                 430         


Met Glu Asn Ala Ile Val Glu Leu Ala Lys Arg Val Asp Asp Arg Val 
        435                 440                 445             


Ser Lys Glu Gly Thr Ser Tyr Gln Asn Leu Gln Arg Leu Ile Glu Asp 
    450                 455                 460                 


Ile Glu Gly Phe Lys Leu Asn 
465                 470     


<210>  59
<211>  452
<212>  PRT
<213>  Cucumis sativus

<400>  59

Met Asp Val Gln Lys Ser Arg Asp Thr Pro Thr Thr Ile Leu Met Leu 
1               5                   10                  15      


Pro Trp Ile Gly Tyr Gly His Leu Ser Ala Tyr Leu Glu Leu Ala Lys 
            20                  25                  30          


Val Leu Ser Arg Arg Asn Asn Phe Leu Ile Tyr Phe Cys Ser Thr Pro 
        35                  40                  45              


Val Asn Leu Asp Ser Ile Lys Pro Arg Leu Ile Pro Ser Ser Ser Ile 
    50                  55                  60                  


Gln Phe Val Glu Leu His Leu Pro Ser Ser Pro Glu Phe Pro Pro His 
65                  70                  75                  80  


Leu His Thr Thr Asn Ala Leu Pro Pro Arg Leu Thr Pro Thr Leu His 
                85                  90                  95      


Lys Ala Phe Ala Ala Ala Ala Ser Pro Phe Glu Ala Ile Leu Gln Thr 
            100                 105                 110         


Leu Cys Pro His Leu Leu Ile Tyr Asp Ser Leu Gln Gln Trp Ala Pro 
        115                 120                 125             


Gln Ile Ala Ser Ser Leu Asn Ile Pro Ala Ile Asn Phe Asn Thr Thr 
    130                 135                 140                 


Ala Ala Ser Ile Ile Ser His Ala Leu His Asn Ile Asn Tyr Pro Asp 
145                 150                 155                 160 


Thr Lys Phe Pro Leu Ser Asp Trp Val Leu His Asn Tyr Trp Lys Gly 
                165                 170                 175     


Lys Tyr Thr Thr Ala Asn Glu Ala Thr Leu Glu Arg Ile Arg Arg Val 
            180                 185                 190         


Arg Glu Ser Phe Leu Tyr Cys Leu Ser Ala Ser Arg Asp Ile Thr Leu 
        195                 200                 205             


Ile Ser Ser Cys Arg Glu Ile Glu Gly Glu Tyr Met Asp Tyr Leu Ser 
    210                 215                 220                 


Val Leu Leu Lys Lys Lys Val Ile Ala Val Gly Pro Leu Val Tyr Glu 
225                 230                 235                 240 


Pro Arg Glu Asp Asp Glu Asp Glu Asp Tyr Ser Arg Ile Lys Asn Trp 
                245                 250                 255     


Leu Asp Lys Lys Glu Ala Leu Ser Thr Val Leu Val Ser Phe Gly Ser 
            260                 265                 270         


Glu Phe Phe Pro Ser Lys Glu Glu Met Glu Glu Ile Gly Cys Gly Leu 
        275                 280                 285             


Glu Glu Ser Gly Ala Asn Phe Ile Trp Val Ile Arg Ser Pro Lys Gly 
    290                 295                 300                 


Glu Glu Asn Lys Arg Val Glu Glu Ala Leu Pro Glu Gly Phe Val Glu 
305                 310                 315                 320 


Lys Ala Gly Glu Arg Ala Met Ile Val Lys Glu Trp Ala Pro Gln Gly 
                325                 330                 335     


Lys Ile Leu Lys His Arg Ser Ile Gly Gly Phe Val Ser His Cys Gly 
            340                 345                 350         


Trp Asn Ser Val Met Glu Ser Ile Met Leu Gly Val Pro Val Ile Ala 
        355                 360                 365             


Val Pro Met His Val Asp Gln Pro Tyr Asn Ala Gly Leu Val Glu Glu 
    370                 375                 380                 


Ala Gly Leu Gly Val Glu Ala Lys Arg Asp Pro Asp Gly Met Ile Gln 
385                 390                 395                 400 


Arg Glu Glu Val Ala Lys Leu Ile Arg Glu Val Val Val Asp Lys Ser 
                405                 410                 415     


Arg Glu Asp Leu Arg Thr Lys Val Ile Glu Met Gly Glu Ile Leu Arg 
            420                 425                 430         


Ser Lys Gly Asp Glu Lys Ile Asp Glu Met Val Ala Gln Ile Ser Leu 
        435                 440                 445             


Leu Leu Lys Ile 
    450         


