                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       YARDEN, Yosef
       GABORIT, Nadege
       LINDZEN, Moshit
 
<120>  ANTI-HER3 ANTIBODIES AND USES OF SAME

<130>  63477

<150>  US 62/047,168
<151>  2014-09-08

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR Amino Acid sequence

<400>  1

Gly Tyr Ser Ile Thr Ser Gly Phe Tyr 
1               5                   


<210>  2
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR Amino Acid sequence

<400>  2

Ile Ala Tyr Asp Gly Thr Ser 
1               5           


<210>  3
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR Amino Acid sequence

<400>  3

Ala Arg Gly Gly Gly Tyr Tyr Gly Gln Leu Leu Asp Tyr 
1               5                   10              


<210>  4
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR Amino Acid sequence

<400>  4

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR Amino Acid sequence

<400>  5

Asn Thr Ala 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR Amino Acid sequence

<400>  6

Gln Gln Gly Lys Thr Leu Pro Trp Thr 
1               5                   


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  7

Gln Asp Ile Arg Asn Tyr 
1               5       


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  8

Tyr Thr Ser 
1           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  9

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  10

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  11

Ile Asn Thr Tyr Ala Gly Glu Pro 
1               5               


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  12

Ala Arg Gly Gly Ile Thr Gly Ala Met Asp Tyr 
1               5                   10      


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  13

Asp His Ile Asn Asn Trp 
1               5       


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  14

Gly Ala Thr 
1           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  15

Gln Gln Tyr Trp Ser Ile Pro Trp Thr 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  16

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
1               5                   


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  17

Ile Tyr Tyr Asp Gly Ser Asn 
1               5           


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Amino Acid sequence

<400>  18

Ala Arg Asp Tyr Asp Val Gly Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of NG 33 polypeptide

<400>  19

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Tyr Trp Ser Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ala Tyr Asp Gly Thr Ser Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Lys Ser Val Thr Asn Glu Asp Thr Pro Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Tyr Tyr Gly Gln Leu Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of NG 33 polypeptide

<400>  20

Asp Ala Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Val Leu Ile 
        35                  40                  45              


Tyr Asn Thr Ala Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  21
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acids sequence of heavy chain of  Clone NG33

<400>  21
gatgtgcagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttttt actggagctg gatccggcag      120

tttccaggaa acaagttgga atggatgggc tatatagcct acgacggtac cagtaactac      180

aatccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa tcagtttttc      240

ctgaagttga aatctgtgac taatgaggac acacctacat attactgtgc aagagggggg      300

ggctactatg gtcagcttct ggactactgg ggtcaaggaa cctcagtcac cgtgtcctca      360

g                                                                      361


<210>  22
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acids sequence of light chain of  Clone NG33

<400>  22
gatgcgcgca tgactcagtc tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaagtcct gatctacaac acagcaaaat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagtaa cctggagcaa      240

gaagattttg ccacttactt ttgccaacag ggtaaaacgc ttccgtggac gttcggtgga      300

ggcaccaagc tcgagctaaa ac                                               322


<210>  23
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CDR Nucleic Acid sequence

<400>  23
caggacatta gcaattat                                                     18


<210>  24
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CDR Nucleic Acid sequence

<400>  24
aacacagca                                                                9


<210>  25
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CDR Nucleic Acid sequence

<400>  25
caacagggta aaacgcttcc gtggacg                                           27


<210>  26
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CDR Nucleic Acid sequence

<400>  26
ggctactcca tcaccagtgg tttttac                                           27


<210>  27
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CDR Nucleic Acid sequence

<400>  27
atagcctacg acggtaccag t                                                 21


<210>  28
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CDR Nucleic Acid sequence

<400>  28
gcaagagggg ggggctacta tggtcagctt ctggactac                              39


<210>  29
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of NG83 polypeptide

<400>  29

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Arg Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Cys Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ala Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Asp Ser Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Ile Thr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of NG83 polypeptide

<400>  30

Asp Val Val Met Thr Gln Lys Thr Ser Ser Leu Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asp Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Ala Ile Lys 
            100                 105         


<210>  31
<211>  355
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acids sequence of heavy chain of NG83

<400>  31
cagatccagt tggtgcagtc tggacctgaa ctgaagaaac gtggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca aactatggaa tgaactgggt gaggcaggct      120

cccggaaagg gtttaaagtg catgggctgg ataaacacct acgctggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggatt cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aagagggggg      300

attacggggg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctcag           355


<210>  32
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acids sequence of light chain of NG83

<400>  32
gatgtagtta tgacacagaa aacatcctcc ctatctacct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca agacattcgc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg ggtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagtga cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtggac gttcggtgga      300

ggcaccaagc tggcaatcaa ac                                               322


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG83

<400>  33
ggatatacct tcacaaacta tgga                                              24


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG83

<400>  34
ataaacacct acgctggaga gcca                                              24


<210>  35
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG83

<400>  35
gcaagagggg ggattacggg ggctatggac tac                                    33


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG83

<400>  36
caagacattc gcaattat                                                     18


<210>  37
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG83

<400>  37
tacacatca                                                                9


<210>  38
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG83

<400>  38
caacagggta atacgcttcc gtggacg                                           27


<210>  39
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of NG140 polypeptide

<400>  39

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Ser Ile Tyr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Val Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser 
        115                 


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of NG140 polypeptide

<400>  40

Asp Ile Val Leu Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  41
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acids sequence of heavy chain of NG140

<400>  41
caggtgcagc ttaaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaaactgga atggatgggc tccatatatt acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccgtc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc aagagattat      300

gacgtagggt atgctatgga ctactggggt caaggagcct cagtcaccgt ctcctcag        358


<210>  42
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acids sequence of light chain of NG140

<400>  42
gacatcgtgc tgacacaatc ttcatcctac ttgtctgtat ctctaggagg cagagtcacc       60

attacttgca aggcaagtga ccacattaat aattggttag cctggtatca gcagaaacca      120

ggaaatgctc ctaggctctt aatatctggt gcaaccagtt tggaaactgg ggttccttca      180

agattcagtg gcagtggatc tggaaaggac tacactctca gcattaccag tcttcagact      240

gaagatgttg ctacttatta ctgtcaacag tattggagta ttccgtggac gttcggtgga      300

ggcaccaagc tagaaatcaa ac                                               322


<210>  43
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG140

<400>  43
ggctactcca tcaccagtgg ttattac                                           27


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  44
atatattacg acggtagcaa t                                                 21


<210>  45
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG140

<400>  45
gcaagagatt atgacgtagg gtatgctatg gactac                                 36


<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  46
gaccacatta ataattgg                                                     18


<210>  47
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG140

<400>  47
ggtgcaacc                                                                9


<210>  48
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CDR of NG140

<400>  48
caacagtatt ggagtattcc gtggacg                                           27


<210>  49
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of XC252 polypeptide

<400>  49

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Tyr Gly Asp Pro Arg Asp Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Asp Trp Tyr Ala Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy CDR1 of XC252 polypeptide

<400>  50

Gly Tyr Thr Phe Thr Asp Tyr Ala 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2 of XC252 polypeptide

<400>  51

Ile Ser Thr Tyr Tyr Gly Asp Pro 
1               5               


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3 of XC252 polypeptide

<400>  52

Ala Arg Gly Asp Tyr Asp Trp Tyr Ala Ile Asp Tyr 
1               5                   10          


<210>  53
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of XC252 polypeptide

<400>  53

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR1 of XC252 polypeptide

<400>  54

Gln Ser Ile Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  55
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR2 of XC252 polypeptide

<400>  55

Lys Val Ser 
1           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3 of XC252 polypeptide

<400>  56

Phe Gln Gly Ser His Val Pro Pro Thr 
1               5                   


