                         SEQUENCE LISTING

<110>  Tel HaShomer Medical Research Infrastructure and Services 
       Ltd.
       Ramot at Tel Aviv University Ltd.
       KOSTENICH, Genady
       ORON-HERMAN, Mor
       ORENSTEIN, Arie
       SHEKHTER, Talia
       GAZIT, Ehud
       SALITRA, Yoseph
       BUZHANSKY, Ludmilla
 
<120>  SYNTHETIC SOMATOSTATIN RECEPTOR LIGANDS

<130>  196'03

<150>  US 62/050,153
<151>  2014-09-14

<150>  US 62/050,155
<151>  2014-09-14

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  HOMO_SAPIENS

<300>
<308>  NP_001039
<309>  2015-03-15
<313>  (1)..(116)

<400>  1

Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Ser Ile Val 
1               5                   10                  15      


Leu Ala Leu Gly Cys Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg 
            20                  25                  30          


Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Ala Gly Lys Gln Glu Leu 
        35                  40                  45              


Ala Lys Tyr Phe Leu Ala Glu Leu Leu Ser Glu Pro Asn Gln Thr Glu 
    50                  55                  60                  


Asn Asp Ala Leu Glu Pro Glu Asp Leu Ser Gln Ala Ala Glu Gln Asp 
65                  70                  75                  80  


Glu Met Arg Leu Glu Leu Gln Arg Ser Ala Asn Ser Asn Pro Ala Met 
                85                  90                  95      


Ala Pro Arg Glu Arg Lys Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr 
            100                 105                 110         


Phe Thr Ser Cys 
        115     


<210>  2
<211>  14
<212>  PRT
<213>  HOMO_SAPIENS

<400>  2

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  


<210>  3
<211>  28
<212>  PRT
<213>  HOMO_SAPIENS

<400>  3

Ser Ala Asn Ser Asn Pro Ala Met Ala Pro Arg Glu Arg Lys Ala Gly 
1               5                   10                  15      


Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
            20                  25              


<210>  4
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-naphthylalanine (D-Nal)

<220>
<221>  DISULFID
<222>  (2)..(7)

<400>  4

Xaa Cys Tyr Trp Lys Val Cys Thr 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(7)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-tryptophan

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-threoninol

<400>  5

Xaa Cys Phe Xaa Lys Thr Cys Xaa 
1               5               


<210>  6
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  FITC-GABA covalently attached to D-Phe at position 1

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Optional FITC-GABA covalently attached to D-Phe at position 1

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<300>
<310>  US7,700,717
<311>  2004-09-24
<312>  2010-04-20
<313>  (1)..(9)

<400>  6

Xaa Cys Phe Trp Xaa Lys Thr Phe Xaa 
1               5                   


<210>  7
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  selected from the group consisting of Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  at least one of: X at position 1 is Tyr,  X at position 2 is 
       present or absent but if present is Phe, X at position 4 is other
       than Lys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  present or absent and if present is selected from the group 
       consisting of Trp and Phe

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-tryptophan

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  group consisting of amino acid residues having a side chain with 
       at least one nitrogen atom

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  "A" a chemical entity covalently attached to Phe

<400>  7

Xaa Xaa Xaa Xaa Thr Phe 
1               5       


<210>  8
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  selected from the group consisting of Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  at least one of: X at position 2 is Tyr,  X at position 3 is 
       present or absent but if present is Phe, X at position 5 is other
       than Lys

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  s present or absent and if present is selected from the group 
       consisting of Trp and Phe

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  selected from the group consisting of amino acid residues having 
       a side chain with at least one nitrogen atom

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  "A" a chemical entity covalently attached to Phe

<400>  8

Arg Xaa Xaa Xaa Xaa Thr Phe 
1               5           


<210>  9
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is selected from HomoCysteine and D-Cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is selected from GlyS2, Cys, HomoCysteine and D-Cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is selected from Cysteine, HomoCysteine and D-Cysteine.

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is present or absent but if present is Arg

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  selected from the group consisting of Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X present or absent and if present is selected from the group 
       consisting of Trp and Phe

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-tryptophan

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is selected from the group consisting of amino acid residues 
       having a side chain with at least one nitrogen atom

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  9

Xaa Xaa Xaa Xaa Xaa Xaa Thr Phe 
1               5               


<210>  10
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  X selected from the group consisting of HomoCysteine and 
       D-Cysteine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is present or absent but if present is Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is selected from the group consisting of Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is present or absent and if present is selected from the group 
       consisting of Trp and Phe

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X is D-tryptophan

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is selected from the group consisting of amino acid residues 
       having a side chain with at least one nitrogen atom

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  A chemical entity covalently bound to Phe

<400>  10

Arg Xaa Xaa Xaa Xaa Xaa Xaa Thr Phe 
1               5                   


<210>  11
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is present or absent and if present is Arg

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  X is selected from the group consisting of HomoCysteine and 
       D-Cysteine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is present or absent and if present is Arg

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is selected from the group consisting of Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is present or absent and if present is selected from the group 
       consisting of Trp and Phe

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-tryptophan

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is selected from the group consisting of amino acid residues 
       having a side chain with at least one nitrogen atom

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  A chemical entity covalently bound to Phe

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  A chemical entity covalently bound to Phe

<400>  11

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Phe 
1               5                   10  


<210>  12
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to D-Phe at 
       position 1

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  12

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-tryptophan

<220>
<221>  BINDING
<222>  (5)..(5)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  13

Phe Xaa Lys Thr Phe 
1               5   


<210>  14
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-tryptophan

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  14

Cys Phe Xaa Lys Thr Phe 
1               5       


<210>  15
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-tryptophan

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  15

Arg Cys Phe Xaa Lys Thr Phe 
1               5           


<210>  16
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-tryptophan

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  16

Xaa Arg Cys Phe Xaa Lys Thr Phe 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to D-Phe

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ornithine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  17

Xaa Cys Phe Trp Xaa Xaa Thr Phe Xaa 
1               5                   


<210>  18
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-tryptophan

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Ornithine

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  18

Phe Trp Xaa Xaa Thr Phe 
1               5       


<210>  19
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Ornithine

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  19

Cys Phe Trp Xaa Xaa Thr Phe 
1               5           


<210>  20
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ornithine

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  20

Xaa Cys Phe Trp Xaa Xaa Thr Phe 
1               5               


<210>  21
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to D-Phe

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  21

Xaa Cys Tyr Trp Xaa Lys Thr Phe Xaa 
1               5                   


<210>  22
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Tryptophan

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  22

Tyr Trp Xaa Lys Thr Phe 
1               5       


<210>  23
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  23

Cys Tyr Trp Xaa Lys Thr Phe 
1               5           


<210>  24
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  24

Xaa Cys Tyr Trp Xaa Lys Thr Phe 
1               5               


<210>  25
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to DPhe

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  FITC-GABA covalently attached to D-Phe at position 1

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ornithine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  25

Xaa Arg Cys Phe Xaa Xaa Thr Phe Xaa 
1               5                   


<210>  26
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ornithine

<220>
<221>  BINDING
<222>  (5)..(5)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  26

Phe Xaa Xaa Thr Phe 
1               5   


<210>  27
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Ornithine

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  27

Cys Phe Xaa Xaa Thr Phe 
1               5       


<210>  28
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Ornithine

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  28

Arg Cys Phe Xaa Xaa Thr Phe 
1               5           


<210>  29
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ornithine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  29

Xaa Arg Cys Phe Xaa Xaa Thr Phe 
1               5               


<210>  30
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to DPhe

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  FITC-GABA covalently attached to D-Phe at position 1

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  30

Xaa Arg Cys Tyr Xaa Lys Thr Phe Xaa 
1               5                   


<210>  31
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (5)..(5)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  31

Tyr Xaa Lys Thr Phe 
1               5   


<210>  32
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Phenylalanine

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  32

Cys Tyr Xaa Lys Thr Phe 
1               5       


<210>  33
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  33

Arg Cys Tyr Xaa Lys Thr Phe 
1               5           


<210>  34
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  34

Xaa Arg Cys Tyr Xaa Lys Thr Phe 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to DPhe

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(8)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Ornithine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  N-Thioethyl glycine

<400>  35

Xaa Cys Tyr Xaa Xaa Thr Phe Xaa 
1               5               


<210>  36
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ornithine

<220>
<221>  BINDING
<222>  (5)..(5)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  36

Tyr Xaa Xaa Thr Phe 
1               5   


<210>  37
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Ornithine

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  37

Cys Tyr Xaa Xaa Thr Phe 
1               5       


<210>  38
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Ornithine

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  38

Xaa Cys Tyr Xaa Xaa Thr Phe 
1               5           


<210>  39
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to DPhe

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(10)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  N-Thioethyl glycine

<400>  39

Xaa Cys Arg Phe Phe Xaa Lys Thr Phe Xaa 
1               5                   10  


<210>  40
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (5)..(5)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  40

Phe Xaa Lys Thr Phe 
1               5   


<210>  41
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  41

Phe Phe Xaa Lys Thr Phe 
1               5       


<210>  42
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Tryptophan

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  42

Arg Phe Phe Xaa Lys Thr Phe 
1               5           


<210>  43
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  43

Cys Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  44
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (9)..(9)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  44

Xaa Cys Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  45
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to  Cys at 
       position 1

<220>
<221>  DISULFID
<222>  (1)..(8)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  N-Thioethyl glycine

<400>  45

Cys Arg Phe Xaa Lys Thr Phe Xaa 
1               5               


<210>  46
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to DPhe at 
       position 1

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  46

Xaa Cys Arg Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  47
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  47

Arg Phe Xaa Lys Thr Phe 
1               5       


<210>  48
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  48

Cys Arg Phe Xaa Lys Thr Phe 
1               5           


<210>  49
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  49

Xaa Cys Arg Phe Xaa Lys Thr Phe 
1               5               


<210>  50
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to D-Phe at 
       position 1

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  HomoCysteine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  50

Xaa Xaa Phe Trp Xaa Lys Thr Phe Xaa 
1               5                   


<210>  51
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Homocysteine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  51

Xaa Xaa Phe Trp Xaa Lys Thr Phe 
1               5               


<210>  52
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to D-Phe at 
       position 1

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Cysteine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  52

Xaa Xaa Phe Trp Xaa Lys Thr Phe Xaa 
1               5                   


<210>  53
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Cysteine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  53

Xaa Xaa Phe Trp Xaa Lys Thr Phe 
1               5               


<210>  54
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to D-Phe at 
       position 1

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  54

Phe Cys Phe Trp Xaa Xaa Thr Phe Xaa 
1               5                   


<210>  55
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-Aminoisobutyric acid

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  55

Phe Trp Xaa Xaa Thr Phe 
1               5       


<210>  56
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  2-Aminoisobutyric acid

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  56

Cys Phe Trp Xaa Xaa Thr Phe 
1               5           


<210>  57
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  2-Aminoisobutyric acid

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  57

Xaa Cys Phe Trp Xaa Xaa Thr Phe 
1               5               


<210>  58
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to D-Phe at 
       position 1

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  acetyllysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  58

Xaa Cys Phe Trp Xaa Xaa Thr Phe Xaa 
1               5                   


<210>  59
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Acetyllysine

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  59

Phe Trp Xaa Xaa Thr Phe 
1               5       


<210>  60
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Acetyllysine

<220>
<221>  BINDING
<222>  (5)..(5)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  60

Cys Phe Trp Xaa Xaa Thr Phe 
1               5           


<210>  61
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  acetyllysine

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  61

Xaa Cys Phe Trp Xaa Xaa Thr Phe 
1               5               


<210>  62
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to D-Phe at 
       position 1

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  62

Xaa Cys Phe Trp Xaa Arg Thr Phe Xaa 
1               5                   


<210>  63
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  63

Xaa Cys Phe Trp Xaa Arg Thr Phe 
1               5               


<210>  64
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Active agent Z or FITC-GABA covalently attached to D-Phe at 
       position 1

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  HomoLysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  64

Xaa Cys Phe Trp Xaa Xaa Thr Phe Xaa 
1               5                   


<210>  65
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  HomoLysine

<220>
<221>  BINDING
<222>  (6)..(6)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  65

Phe Trp Xaa Xaa Thr Phe 
1               5       


<210>  66
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  HomoLysine

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  66

Cys Phe Trp Xaa Xaa Thr Phe 
1               5           


<210>  67
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  HomoLysine

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  "A" is a chemical entity covalently attached to Phe

<400>  67

Xaa Cys Phe Trp Xaa Xaa Thr Phe 
1               5               


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(9)

<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  B' is any chemical entity covalently bonded to the terminal amino
       group of the N-terminal amino acid residue

<220>
<221>  MOD_RES
<222>  (2)..(8)
<223>  Peptide is 6-9 amino acid residues, therefore three of the seven

       internal residues are optionally present or absent.

<220>
<221>  MOD_RES
<222>  (4)..(7)
<223>  At least one of 4, 5, 6, 7 internal amino acids  includes a side 
       chain functional group having a nitrogen atom (N) to which a 
       nanoparticle active agent moiety is covalently attached (Q in 
       Figure 13)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  B is any chemical entity covalently bonded to the terminal 
       carbonyl group of the N-terminal amino acid residue

<400>  68

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-Thioethyl glycine

<220>
<221>  DISULFID
<222>  (1)..(8)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-tryptophan

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  N-Thioethyl glycine

<300>
<310>  US 7,700,717
<311>  2004-09-24
<312>  2010-04-20

<400>  69

Xaa Phe Trp Xaa Lys Thr Phe Xaa 
1               5               


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1 )
<223>  D-tryptophan

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-Thioethyl glycine

<220>
<221>  DISULFID
<222>  (2)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<300>
<310>  US 7,700,717
<311>  2004-09-24
<312>  2010-04-20

<400>  70

Xaa Xaa Phe Trp Xaa Lys Thr Phe Xaa 
1               5                   


