                         SEQUENCE LISTING

<110>  REPROPHARM
       KARA, Elodie
       DECOURTYE, Jrmye
       CASTERET, Sophie
       MAUREL, Marie-Christine
 
<120>  LIGANDS POTENTIALISANTS DE LA BIOACTIVITE DES GONADOTROPHINES

<130>  BNT213486PC01

<150>  FR1558078
<151>  2014-09-10

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH CA5

<400>  1
gaggtgaagc tggtggaatc tggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcagt gatttctaca tggagtgggt ccgccagcct      120

ccagggaaga gactggagtg gattgctgca agtagaaaca aagctaagga ttatacaaca      180

gagtacagtg catctgtgaa gggtcggttc atcgtctcca gagacacttc ccaaagcatc      240

ctctaccttc agatgaatgc cctgagagct gaggacactg ccatttattt ctgtgcaaga      300

gatgcaaggt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  2
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CA5

<400>  2

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Lys Asp Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Ala Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  3
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL CA5

<400>  3
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaagattact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

cctcggacgt tcggtggagg caccaagctg gaaatcaaa                             339


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CA5

<400>  4

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Ile Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  5
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH CH10

<400>  5
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat acctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtgaga      300

caggattact acggtagtag ctactttgac tactggggcc aaggcaccac tctcacagtc      360

tcctca                                                                 366


<210>  6
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CH10

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gln Asp Tyr Tyr Gly Ser Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  7
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL CH10

<400>  7
gacattgtga tgactcagtc tccagccacc ctgtctgtga ctccaggaga tagagtctct       60

ctttcctgca gggccagcca gagtattagc gactacttac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaaatat gcttcccaat ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggtcagat ttcactctca gtatcaacag tgtggaacct      240

gaagatgttg gagtgtatta ctgtcaaaat ggtcacagct ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CH10

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 CA5

<400>  9

Gly Phe Thr Phe Ser Asp Phe Tyr 
1               5               


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 CA5

<400>  10

Ser Arg Asn Lys Ala Lys Asp Tyr Thr Thr 
1               5                   10  


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 CA5

<400>  11

Ala Arg Asp Ala Arg Phe Ala Tyr 
1               5               


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 CA5

<400>  12

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 CA5

<400>  13

Gln Gln Tyr Tyr Ser Tyr Pro Arg Thr 
1               5                   


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 CH10

<400>  14

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 CH10

<400>  15

Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 CH10

<400>  16

Val Arg Gln Asp Tyr Tyr Gly Ser Ser Tyr Phe Asp Tyr 
1               5                   10              


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 CH10

<400>  17

Gln Ser Ile Ser Asp Tyr 
1               5       


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 CH10

<400>  18

Gln Asn Gly His Ser Phe Pro Tyr Thr 
1               5                   


<210>  19
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv CA5

<400>  19
caggtgcagc tgcagcagtc aggcggcggc ctggtacaac ctggtggctc actgcgcctg       60

agctgcgcaa ccagcggttt tacctttagc gatttctaca tggaatgggt tcgccaaccg      120

ccgggtaagc gtctggaatg gatcgcggcg agccgtaaca aggcgaaaga ttataccact      180

gaatatagcg cgtcggtgaa aggtcgcttc attgtctcgc gcgataccag ccagtcgatt      240

ctgtatctgc aaatgaatgc cctgcgtgcc gaagacacgg ccatctactt ctgtgcgcgt      300

gatgcacgct ttgcctattg gggccaaggc accctggtga ccgttagcgc cggtggtggc      360

ggttcaggtg gtggcggtag cggtggcggt ggctcagata ttcagatgac ccagaccccg      420

tcaagcctgg cggtgtcagt cggcgaagag attactatga gctgtaaaag ctcgcagagc      480

ctgctgtact catcgaacca gaaaaattac ctggcatggt atcaacagaa gccgggtcag      540

tcgccgaaac tgctgatcta ctgggcctca acccgtgaga gcggcgtacc ggatcgcttt      600

actggcagcg gcagcggcac ggactttacg ctgacgatta gctcggtgaa ggccgaagac      660

ctggcggttt attattgcca acagtactat agctaccctc gtaccttcgg cggcggcacg      720

aaactcgaga ttaaacatca ccatcaccat cactaactcg agatcaagta a               771


<210>  20
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv CA5

<400>  20

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Lys Asp Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Ala Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ala 
    130                 135                 140                 


Val Ser Val Gly Glu Glu Ile Thr Met Ser Cys Lys Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys His His His His His His 
                245                 250     


<210>  21
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv CH10

<400>  21
caggtgcagc tgcagcaatc aggcggcggc ctggtccaac cgaaaggtag cctgaaactg       60

tcgtgcgccg ccagcggctt tacgttcaac acttacgcga tgaattgggt gcgtcaggcg      120

cctggtaaag gcctggaatg ggtggcacgc atccgttcaa aaagcaacaa ttacgcgacg      180

tattatgcag acagcgtaaa agatcgcttt accatcagcc gtgatgattc acagtcaatg      240

ctgtacctgc aaatgaataa cctgaaaact gaagacactg cgatgtatta ttgtgttcgc      300

caggactatt acggtagctc gtatttcgat tactggggcc aaggcaccac cctgacggtg      360

agctcgggtg gcggtggctc aggtggtggt ggtagcggcg gtggcggtag cgatatccag      420

atgacccaga ccccggcaac cctgagcgtt acccctggtg accgcgtttc gctgagctgc      480

cgtgcctcgc agagcatttc ggactatctg cactggtatc agcaaaaatc acacgaatca      540

ccgcgtctgc tgattaagta cgccagccaa tcgattagcg gtattccgag ccgcttttcg      600

ggctcgggtt cgggctcgga ttttaccctg tcaattaata gcgtagagcc ggaagatgta      660

ggcgtctact attgtcagaa cggccattca ttcccgtaca cgtttggcgg cggcaccaag      720

ctcgagatta agcatcacca tcatcaccat taactcgaga tcaagtaa                   768


<210>  22
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv CH10

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gln Asp Tyr Tyr Gly Ser Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
    130                 135                 140                 


Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile 
            180                 185                 190         


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe 
        195                 200                 205             


Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Asn Gly His Ser Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys His His His His His His 
                245                 250 


<210>  23
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHRev1

<400>  23
cgggatcctc tagaggtcca actgcaggag tcagg                                  35


<210>  24
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHFor

<400>  24
caggggccag tggatagac                                                    19


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MKRev5

<400>  25
gacattgtga tgacccagtc t                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MKC5For

<400>  26
ggatacagtt ggtgcagcat c                                                 21


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CA5VH_Fw

<400>  27
cacttttaca tggtatccag tg                                                22


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CA5VH_Rev

<400>  28
gtttctactt gcagcaatcc act                                               23


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CA5VL_Fw


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  W = A ou T

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  R = G ou A

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Y = T ou C

<400>  29
gawtcacagr cccaggtyc                                                    19


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CA5VL_Rev

<400>  30
cccagtaaat cagcagttta gga                                               23


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MuCFor

<400>  31
ggggaagaca tttgggaagg                                                   20


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MKRev2

<400>  32
gatattgtga tgacgcaggc t                                                 21


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MKRev3

<400>  33
gatattgtga taacccag                                                     18


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MKRev4

<400>  34
gacattgtgc tgacccaatc t                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MKRev6

<400>  35
gatattgtgc taactcagtc t                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MKRev8

<400>  36
gacatccagc tgactcagtc t                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MKC5for

<400>  37
ggatacagtt ggtgcagcat c                                                 21


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH10VH_Fw

<400>  38
atggtgttgg ggctgaagtg                                                   20


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH10VH_Rev

<400>  39
cagttcatgg cgtaggtatt ga                                                22


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH10VL_Fw

<400>  40
ttctggaytt cagcctccag                                                   20


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH10VL_Rev

<400>  41
gattgggaag catatttgat gag                                               23


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lieur

<400>  42

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment VL de scFv

<400>  43

Leu Glu Ile Lys His His His His His His Leu Glu Ile Lys Val Asp 
1               5                   10                  15      


<210>  44
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL CA5

<400>  44
gatattcaga tgacccagac cccgtcaagc ctggcggtgt cagtcggcga agagattact       60

atgagctgta aaagctcgca gagcctgctg tactcatcga accagaaaaa ttacctggca      120

tggtatcaac agaagccggg tcagtcgccg aaactgctga tctactgggc ctcaacccgt      180

gagagcggcg taccggatcg ctttactggc agcggcagcg gcacggactt tacgctgacg      240

attagctcgg tgaaggccga agacctggcg gtttattatt gccaacagta ctatagctac      300

cctcgtacct tcggcggcgg cacgaaactt gagattaaac atcaccatca ccatcactaa      360


<210>  45
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CA5

<400>  45

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Glu Ile Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys His His His His His His 
        115                 


<210>  46
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH CA5

<400>  46
caggtgcagc tgcagcagtc aggcggcggc ctggtacaac ctggtggctc actgcgcctg       60

agctgcgcaa ccagcggttt tacctttagc gatttctaca tggaatgggt tcgccaaccg      120

ccgggtaagc gtctggaatg gatcgcggcg agccgtaaca aggcgaaaga ttataccact      180

gaatatagcg cgtcggtgaa aggtcgcttc attgtctcgc gcgataccag ccagtcgatt      240

ctgtatctgc aaatgaatgc cctgcgtgcc gaagacacgg ccatctactt ctgtgcgcgt      300

gatgcacgct ttgcctattg gggccaaggc accctggtga ccgttagcgc ccatcaccat      360

caccatcact aa                                                          372


<210>  47
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CA5

<400>  47

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Lys Asp Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Ala Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala His His His His His His 
        115                 120             


<210>  48
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScFv CA5 inverse

<400>  48
gatattcaga tgacccagac cccgtcaagc ctggcggtgt cagtcggcga agagattact       60

atgagctgta aaagctcgca gagcctgctg tactcatcga accagaaaaa ttacctggca      120

tggtatcaac agaagccggg tcagtcgccg aaactgctga tctactgggc ctcaacccgt      180

gagagcggcg taccggatcg ctttactggc agcggcagcg gcacggactt tacgctgacg      240

attagctcgg tgaaggccga agacctggcg gtttattatt gccaacagta ctatagctac      300

cctcgtacct tcggcggcgg cacgaaactt gagattaaag gtggtggcgg ttcaggtggt      360

ggcggtagcg gtggcggtgg ctcacaggtg cagctgcagc agtcaggcgg cggcctggta      420

caacctggtg gctcactgcg cctgagctgc gcaaccagcg gttttacctt tagcgatttc      480

tacatggaat gggttcgcca accgccgggt aagcgtctgg aatggatcgc ggcgagccgt      540

aacaaggcga aagattatac cactgaatat agcgcgtcgg tgaaaggtcg cttcattgtc      600

tcgcgcgata ccagccagtc gattctgtat ctgcaaatga atgccctgcg tgccgaagac      660

acggccatct acttctgtgc gcgtgatgca cgctttgcct attggggcca aggcaccctg      720

gtgaccgtta gcgcccatca ccatcaccat cactaa                                756


<210>  49
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScFv CA5 inverse

<400>  49

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Glu Ile Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
145                 150                 155                 160 


Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
                165                 170                 175     


Ala Ala Ser Arg Asn Lys Ala Lys Asp Tyr Thr Thr Glu Tyr Ser Ala 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
        195                 200                 205             


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
    210                 215                 220                 


Phe Cys Ala Arg Asp Ala Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ala His His His His His His 
                245                 250     


<210>  50
<211>  92
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  sous-unit alpha hFSH, hCG et hLH

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = Leu ou Phe

<400>  50

Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro 
1               5                   10                  15      


Xaa Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys 
            20                  25                  30          


Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu 
        35                  40                  45              


Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ser 
    50                  55                  60                  


Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys Val Glu Asn His Thr 
65                  70                  75                  80  


Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90          


<210>  51
<211>  96
<212>  PRT
<213>  Ovis aries


<220>
<221>  misc_feature
<223>  sous-unit alpha oLH et oFSH

<400>  51

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Pro Asp Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Val Arg Val 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  52
<211>  96
<212>  PRT
<213>  Sus scrofa


<220>
<221>  misc_feature
<223>  sous-unit alpha pLH et pFSH

<400>  52

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Leu Gly Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Ala Arg Val 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  53
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  sous-unit bta hFSH

<400>  53

Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu 
1               5                   10                  15      


Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys 
            20                  25                  30          


Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
        35                  40                  45              


Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro 
    50                  55                  60                  


Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr 
65                  70                  75                  80  


Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val 
                85                  90                  95      


Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys Glu 
            100                 105                 110     


<210>  54
<211>  132
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  sous-unit bta hCG

<400>  54

Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala Thr Leu 
1               5                   10                  15      


Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr Val Asn Thr Thr 
            20                  25                  30          


Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val Leu Gln Gly Val 
        35                  40                  45              


Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg Asp Val Arg Phe 
    50                  55                  60                  


Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val Asn Pro Val Val 
65                  70                  75                  80  


Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg Arg Ser 
                85                  90                  95      


Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu Thr Cys Asp Asp 
            100                 105                 110         


Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
        115                 120                 125             


Pro Ser Pro Ser 
    130         


<210>  55
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  sous-unit bta hLH

<400>  55

Ser Arg Glu Pro Leu Arg Pro Arg Pro Trp Cys His Pro Ile Asn Ala 
1               5                   10                  15      


Ile Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr Val Asn 
            20                  25                  30          


Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Met Arg Val Leu Gln 
        35                  40                  45              


Ala Val Leu Pro Pro Leu Pro Gln Val Val Cys Thr Tyr Arg Asp Val 
    50                  55                  60                  


Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val Asp Pro 
65                  70                  75                  80  


Val Val Ser Phe Pro Val Ala Leu Ser Cys Arg Cys Gly Pro Cys Arg 
                85                  90                  95      


Arg Ser Thr Ser Asp Cys Gly Gly Pro Lys Asp His Pro Leu Thr Cys 
            100                 105                 110         


Asp His Pro Gln Leu Ser Gly Leu Leu Phe Leu 
        115                 120             


<210>  56
<211>  121
<212>  PRT
<213>  Ovis aries


<220>
<221>  misc_feature
<223>  sous-unit bta oLH

<400>  56

Ser Arg Gly Pro Leu Arg Pro Leu Cys Gln Pro Ile Asn Ala Thr Leu 
1               5                   10                  15      


Ala Ala Glu Lys Glu Ala Cys Pro Val Cys Ile Thr Phe Thr Thr Ser 
            20                  25                  30          


Ile Cys Ala Gly Tyr Cys Leu Ser Met Lys Arg Val Leu Pro Val Ile 
        35                  40                  45              


Leu Pro Pro Met Pro Gln Arg Val Cys Thr Tyr His Glu Leu Arg Phe 
    50                  55                  60                  


Ala Ser Val Arg Leu Pro Gly Cys Pro Pro Gly Val Asp Pro Met Val 
65                  70                  75                  80  


Ser Phe Pro Val Ala Leu Ser Cys His Cys Gly Pro Cys Arg Leu Ser 
                85                  90                  95      


Ser Thr Asp Cys Gly Gly Pro Arg Thr Gln Pro Leu Ala Cys Asp His 
            100                 105                 110         


Pro Pro Leu Pro Asp Ile Leu Phe Leu 
        115                 120     


<210>  57
<211>  121
<212>  PRT
<213>  Sus scrofa


<220>
<221>  misc_feature
<223>  sous-unit bta pLH

<400>  57

Ser Arg Gly Pro Leu Arg Pro Leu Cys Arg Pro Ile Asn Ala Thr Leu 
1               5                   10                  15      


Ala Ala Glu Asn Glu Ala Cys Pro Val Cys Ile Thr Phe Thr Thr Ser 
            20                  25                  30          


Ile Cys Ala Gly Tyr Cys Pro Ser Met Val Arg Val Leu Pro Ala Ala 
        35                  40                  45              


Leu Pro Pro Val Pro Gln Pro Val Cys Thr Tyr Arg Glu Leu Ser Phe 
    50                  55                  60                  


Ala Ser Ile Arg Leu Pro Gly Cys Pro Pro Gly Val Asp Pro Thr Val 
65                  70                  75                  80  


Ser Phe Pro Val Ala Leu Ser Cys His Cys Gly Pro Cys Arg Leu Ser 
                85                  90                  95      


Ser Ser Asp Cys Gly Gly Pro Arg Ala Gln Pro Leu Ala Cys Asp Arg 
            100                 105                 110         


Pro Leu Leu Pro Gly Leu Leu Phe Leu 
        115                 120     


<210>  58
<211>  110
<212>  PRT
<213>  Ovis aries


<220>
<221>  misc_feature
<223>  sous-unit bta oFSH

<400>  58

Ser Cys Glu Leu Thr Asn Ile Thr Ile Thr Val Glu Lys Glu Glu Cys 
1               5                   10                  15      


Ser Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr 
            20                  25                  30          


Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Asn Ile Gln Lys 
        35                  40                  45              


Ala Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Lys Val Pro Gly 
    50                  55                  60                  


Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Glu 
65                  70                  75                  80  


Cys His Cys Gly Lys Cys Asp Arg Asp Ser Thr Asp Cys Thr Val Arg 
                85                  90                  95      


Gly Leu Gly Pro Ser Tyr Cys Ser Phe Ser Asp Ile Arg Glu 
            100                 105                 110 


<210>  59
<211>  109
<212>  PRT
<213>  Sus scrofa


<220>
<221>  misc_feature
<223>  sous-unit bta pFSH

<400>  59

Cys Glu Leu Thr Asn Ile Thr Ile Thr Val Glu Lys Glu Glu Cys Gly 
1               5                   10                  15      


Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr 
            20                  25                  30          


Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Asn Ile Gln Lys Thr 
        35                  40                  45              


Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Lys Val Pro Gly Cys 
    50                  55                  60                  


Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Glu Cys 
65                  70                  75                  80  


His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val Arg Gly 
                85                  90                  95      


Leu Gly Pro Ser Tyr Cys Ser Phe Ser Glu Met Lys Glu 
            100                 105                 


<210>  60
<211>  49
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Rgion N terminale du rcepteur de la hFSH

<400>  60

Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys Gln 
1               5                   10                  15      


Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala Ile 
            20                  25                  30          


Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly Ala 
        35                  40                  45              


Phe 
    


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CA5 sur btaFSH

<400>  61

Arg Phe Cys Ile Ser Ile Asn 
1               5           


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CA5 sur btaFSH

<400>  62

Arg Val Pro Gly Cys Ala 
1               5       


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CA5 sur btaFSH

<400>  63

Arg Gly Leu Gly Ser Tyr Cys Ser Phe Gly Glu Met 
1               5                   10          


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CA5 sur rcepteur de la hFSH

<400>  64

His His Arg Ile His 
1               5   


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CA5 sur rcepteur de la hFSH

<400>  65

Leu Gln Glu Lys 
1               


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CH10 sur alphaFSH

<400>  66

Gln Asp Cys Pro Glu 
1               5   


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CH10 sur btaFSH

<400>  67

Ser Cys Glu Leu Thr Asn Ile Thr 
1               5               


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CH10 sur btaFSH

<400>  68

Ser Asn Trp Ala Gly Tyr 
1               5       


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CH10 sur btaFSH

<400>  69

Leu Gly Pro Ser Tyr Gly Glu Met 
1               5               


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion pitopique de CH10 sur rcepteur de la hFSH

<400>  70

Cys His His Cys Ser 
1               5   


