                         SEQUENCE LISTING

<110>  Pfeifer & Langen GmbH & Co. KG
 
<120>  Cellobiose-Phosphorylase

<130>  PFL0002-WO

<150>  EP14184301
<151>  2014-09-10

<150>  EP14190891
<151>  2014-10-29

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  822
<212>  PRT
<213>  Cellulomonas uda

<400>  1

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Gln Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asp His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Ala Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  2
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  2

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asp His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Ala Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  3
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  3

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Gln Thr Asn Phe Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asp His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Ala Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  4
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  4

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Gln Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asp His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Ala Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  5
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  5

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Gln Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Ala Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  6
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  6

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Gln Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asp His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  7
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  7

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Gln Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asp His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Ala Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  8
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  8

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  9
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  9

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Lys Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  10
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  10

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Met Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  11
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  11

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Phe Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  12
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  12

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Ser Val Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  13
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  13

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  14
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  14

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  15
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  15

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Val Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Glu His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  16
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  16

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Ser Thr Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  17
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  17

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Ile Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Val 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  18
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  18

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Phe Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Val 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  19
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  19

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Phe Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Val 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  20
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtye sequence

<400>  20

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Met Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Val 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  21
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtype sequence

<400>  21

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Val Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Val 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  22
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtype sequence

<400>  22

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Val Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Glu His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Val 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  23
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtype sequence

<400>  23

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Val Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asn Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Val 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  24
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtype sequence

<400>  24

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Val Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Val 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Asn Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  25
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtype sequence

<400>  25

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Val Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Ile Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  26
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtype sequence

<400>  26

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Val Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Ile Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  27
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtype sequence

<400>  27

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Val Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asn Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Glu His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Val 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  28
<211>  822
<212>  PRT
<213>  artificial

<220>
<223>  modified wildtype sequence

<400>  28

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Met Thr Asn Tyr Gln Arg Asn Leu Val Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asn His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Leu Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Ala Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asn Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Ile Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Thr Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Val Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


