﻿               SEQUENCE LISTING

<110> Ruprecht-Karls-Universität Heidelberg

<120> CONSTRUCT FOR THE DELIVERY OF A MOLECULE INTO THE CYTOPLASM OF A CELL

<130> X1963 PCT S3

<150> EP 14 18 3990.2
<151> 2014-09-08

<160> 26

<170> BiSSAP 1.2

<210> 1
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 1
Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly Ile 
1               5                   10                  15      



<210> 2
<211> 242
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe 
    130                 135                 140                 
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 
Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     
Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val 
            180                 185                 190         
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 
Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 
Lys Arg 
        

<210> 3
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 3
Met Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
1               5                   10                  15      
Gly Ile Val 
            

<210> 4
<211> 104
<212> PRT
<213> Rana pipiens


<220> 
<221> MOD_RES
<222> 1
<223> Pyroglutamate

<400> 4
Gln Asp Trp Leu Thr Phe Gln Lys Lys His Ile Thr Asn Thr Arg Asp 
1               5                   10                  15      
Val Asp Cys Asp Asn Ile Met Ser Thr Asn Leu Phe His Cys Lys Asp 
            20                  25                  30          
Lys Asn Thr Phe Ile Tyr Ser Arg Pro Glu Pro Val Lys Ala Ile Cys 
        35                  40                  45              
Lys Gly Ile Ile Ala Ser Lys Asn Val Leu Thr Thr Ser Glu Phe Tyr 
    50                  55                  60                  
Leu Ser Asp Cys Asn Val Thr Ser Arg Pro Cys Lys Tyr Lys Leu Lys 
65                  70                  75                  80  
Lys Ser Thr Asn Lys Phe Cys Val Thr Cys Glu Asn Gln Ala Pro Val 
                85                  90                  95      
His Phe Val Gly Val Gly Ser Cys 
            100                 

<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 5
Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile 
1               5                   10                  15      



<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 6
Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu 
1               5                   10                  15      



<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 7
Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly Val 
1               5                   10                  15      



<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 8
Asp Arg Gly Trp His Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile 
1               5                   10                  15      



<210> 9
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 9
Asp Arg Gly Trp His Asn Gly Cys Gly Phe Phe Gly Lys Gly Ser Ile 
1               5                   10                  15      



<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 10
Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Met 
1               5                   10                  15      



<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 11
Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Tyr 
1               5                   10                  15      



<210> 12
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 12
Asp Arg Gly Trp Asn Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu 
1               5                   10                  15      



<210> 13
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 13
Asn Arg Gly Trp Asn Asn Gly Cys Gly Leu Phe Gly Lys Gly Asp Ile 
1               5                   10                  15      



<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 14
Asp Arg Gly Trp Gly Asn His Cys Gly Leu Phe Gly Lys Gly Ser Ile 
1               5                   10                  15      



<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 15
Asp Arg Gly Trp Gly Asn Asn Cys Gly Leu Phe Gly Lys Gly Ser Ile 
1               5                   10                  15      



<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 16
Asp Arg Gly Trp Gly Asn Gly Cys Ala Leu Phe Gly Lys Gly Ser Ile 
1               5                   10                  15      



<210> 17
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 17
Asp Arg Gly Trp Gly Asn His Cys Gly Phe Phe Gly Lys Gly Ser Ile 
1               5                   10                  15      



<210> 18
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 18
Asp Arg Gly Trp Asp Ser Gly Cys Phe Ile Phe Gly Lys Gly Glu Val 
1               5                   10                  15      



<210> 19
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 19
Asn Arg Gly Trp Gly Thr Gly Cys Phe Lys Trp Gly Ile Gly Phe Val 
1               5                   10                  15      



<210> 20
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> viral fusogenic sequence

<400> 20
Asn Arg Gly Trp Gly Thr Gly Cys Phe Glu Trp Gly Leu Gly Gln Val 
1               5                   10                  15      



<210> 21
<211> 495
<212> PRT
<213> Dengue virus (Glycoprotein E Serotype 2)


<400> 21
Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      
Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          
Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              
Glu Ala Lys His Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  
Leu Thr Asn Thr Thr Thr Ala Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  
Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      
Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         
Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             
Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 
Ser Gly Glu Glu Asn Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 
Glu Ile Lys Val Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     
Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         
Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val 
        195                 200                 205             
His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 
Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 
Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     
Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         
Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             
Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 
Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 
Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     
Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         
Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             
Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 
Gly Gln Leu Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 
Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     
Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         
Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             
Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Val Ile Thr 
    450                 455                 460                 
Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser Leu Val 
465                 470                 475                 480 
Leu Val Gly Val Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 

<210> 22
<211> 156
<212> PRT
<213> Homo sapiens

<220> 
<223> Human pancreatic RNase (RNase 1)

<400> 22
Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      
Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          
Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              
Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  
Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  
Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      
Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         
Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             
Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 
Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
145                 150                 155     

<210> 23
<211> 147
<212> PRT
<213> Homo sapiens

<220> 
<223> Human Angiogenin (RNase 5) P03950

<400> 23
Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      
Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg Tyr Thr His 
            20                  25                  30          
Phe Leu Thr Gln His Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg 
        35                  40                  45              
Tyr Cys Glu Ser Ile Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys 
    50                  55                  60                  
Asp Ile Asn Thr Phe Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile 
65                  70                  75                  80  
Cys Glu Asn Lys Asn Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser 
                85                  90                  95      
Lys Ser Ser Phe Gln Val Thr Thr Cys Lys Leu His Gly Gly Ser Pro 
            100                 105                 110         
Trp Pro Pro Cys Gln Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val 
        115                 120                 125             
Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe 
    130                 135                 140                 
Arg Arg Pro 
145         

<210> 24
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized anti-CD22 scFv (SGIII)

<400> 24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr 
            20                  25                  30          
Asp Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Ser Gly Tyr Gly Ser Ser Tyr Gly Val Leu Phe Ala Tyr 
            100                 105                 110         
Trp Gly Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Leu Gln Gln Lys 
                165                 170                 175     
Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Ile Leu His 
            180                 185                 190         
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        195                 200                 205             
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 
Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 
Leu Glu Ile Lys Arg 
                245 

<210> 25
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..25
<223> /mol_type="unassigned DNA"
      /note="ESR-1s fwd"
      /organism="Artificial Sequence"

<400> 25
tatagaagtg cagctggttg aaagc                                          25


<210> 26
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..25
<223> /mol_type="unassigned DNA"
      /note="ESR-2as rev"
      /organism="Artificial Sequence"

<400> 26
tataggatcc acgtttaatt tccag                                          25


