                         SEQUENCE LISTING

<110>  Fraunhofer-Gesellschaft zur Frderung der angewandten 
       Forschung e.V
 
<120>  THREE-COMPONENT-MULTISTAGE MALARIA VACCINE

<130>  FRA-PA11_PCT

<150>  EP14183995
<151>  2014-09-08

<150>  US62/047,286
<151>  2014-09-08

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  521
<212>  PRT
<213>  Plasmodium falciparum

<400>  1

Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr His Pro 
1               5                   10                  15      


Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro Leu His 
            20                  25                  30          


Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu Asn Thr 
        35                  40                  45              


Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro Ala Pro 
    50                  55                  60                  


Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg Ser Asn 
65                  70                  75                  80  


Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp Ile Glu 
                85                  90                  95      


Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp Ala Glu 
            100                 105                 110         


Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro Val Phe 
        115                 120                 125             


Gly Lys Gly Ile Ile Ile Glu Asn Ser Gln Thr Thr Phe Leu Thr Pro 
    130                 135                 140                 


Val Ala Thr Glu Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala Phe Pro 
145                 150                 155                 160 


Pro Thr Lys Pro Leu Met Ser Pro Met Thr Leu Asp Gln Met Arg His 
                165                 170                 175     


Phe Tyr Lys Asp Asn Glu Tyr Val Lys Asn Leu Asp Glu Leu Thr Leu 
            180                 185                 190         


Cys Ser Arg His Ala Gly Asn Met Asn Pro Asp Asn Asp Lys Asn Ser 
        195                 200                 205             


Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Asp Lys Asp Lys Lys Cys His 
    210                 215                 220                 


Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr Cys Asn 
225                 230                 235                 240 


Lys Asp Glu Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro Ala Lys 
                245                 250                 255     


Asp Lys Ser Phe Gln Asn Tyr Val Tyr Leu Ser Lys Asn Val Val Asp 
            260                 265                 270         


Asn Trp Glu Lys Val Cys Pro Arg Lys Asn Leu Glu Asn Ala Lys Phe 
        275                 280                 285             


Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val Asn Glu 
    290                 295                 300                 


Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn Lys Leu Val Phe Glu Leu 
305                 310                 315                 320 


Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr Asp Tyr 
                325                 330                 335     


Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met Ile Arg 
            340                 345                 350         


Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr Lys Ser 
        355                 360                 365             


His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Arg Lys Thr Gln Lys 
    370                 375                 380                 


Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp Lys Ser 
385                 390                 395                 400 


Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Ile Glu Val Glu His Asn 
                405                 410                 415     


Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile Lys Lys Glu Ile Glu Arg 
            420                 425                 430         


Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly Asn Lys 
        435                 440                 445             


Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Lys Asp Ser Leu 
    450                 455                 460                 


Lys Cys Pro Cys Asp Pro Glu Ile Val Ser Gln Ser Thr Cys Asn Phe 
465                 470                 475                 480 


Phe Val Cys Lys Cys Val Glu Lys Arg Ala Glu Val Thr Ser Asn Asn 
                485                 490                 495     


Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp Ile Pro 
            500                 505                 510         


Glu His Lys Pro Thr Tyr Asp Lys Met 
        515                 520     


<210>  2
<211>  521
<212>  PRT
<213>  Plasmodium falciparum

<400>  2

Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr His Pro 
1               5                   10                  15      


Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro Leu His 
            20                  25                  30          


Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu Asn Thr 
        35                  40                  45              


Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro Ala Pro 
    50                  55                  60                  


Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg Ser Asn 
65                  70                  75                  80  


Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp Ile Glu 
                85                  90                  95      


Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp Ala Glu 
            100                 105                 110         


Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro Val Phe 
        115                 120                 125             


Gly Lys Gly Ile Ile Ile Glu Asn Ser Gln Thr Thr Phe Leu Lys Pro 
    130                 135                 140                 


Val Ala Thr Gly Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala Phe Pro 
145                 150                 155                 160 


Pro Thr Asn Pro Leu Ile Ser Pro Met Thr Leu Asn Gly Met Arg Asp 
                165                 170                 175     


Phe Tyr Lys Asn Asn Glu Tyr Val Lys Asn Leu Asp Glu Leu Thr Leu 
            180                 185                 190         


Cys Ser Arg His Ala Gly Asn Met Asn Pro Asp Asn Asp Glu Asn Ser 
        195                 200                 205             


Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr Asn Asp Lys Lys Cys His 
    210                 215                 220                 


Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr Cys Asn 
225                 230                 235                 240 


Lys Asp Glu Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro Ala Lys 
                245                 250                 255     


Asp Lys Leu Phe Glu Asn Tyr Val Tyr Leu Ser Lys Asn Val Val His 
            260                 265                 270         


Asn Trp Glu Glu Val Cys Pro Arg Lys Asn Leu Glu Asn Ala Lys Phe 
        275                 280                 285             


Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val Asn Glu 
    290                 295                 300                 


Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn Lys Leu Val Phe Glu Leu 
305                 310                 315                 320 


Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr Asp Tyr 
                325                 330                 335     


Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met Ile Arg 
            340                 345                 350         


Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr Lys Ser 
        355                 360                 365             


Arg Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Arg Lys Thr Gln Lys 
    370                 375                 380                 


Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp Lys Ser 
385                 390                 395                 400 


Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Ile Glu Val Glu Asn Asn 
                405                 410                 415     


Phe Pro Cys Ser Leu Tyr Lys Asn Glu Ile Met Lys Glu Ile Glu Arg 
            420                 425                 430         


Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly Asn Lys 
        435                 440                 445             


Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Lys Asp Ser Leu 
    450                 455                 460                 


Lys Cys Pro Cys Asp Pro Glu Met Val Ser Gln Ser Thr Cys Arg Phe 
465                 470                 475                 480 


Phe Val Cys Lys Cys Val Glu Arg Arg Ala Glu Val Thr Ser Asn Asn 
                485                 490                 495     


Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp Ile Pro 
            500                 505                 510         


Glu His Lys Pro Thr Tyr Asp Asn Met 
        515                 520     


<210>  3
<211>  521
<212>  PRT
<213>  Plasmodium falciparum

<400>  3

Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr His Pro 
1               5                   10                  15      


Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro Leu His 
            20                  25                  30          


Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu Asn Thr 
        35                  40                  45              


Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro Ala Pro 
    50                  55                  60                  


Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg Ser Asn 
65                  70                  75                  80  


Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp Ile Glu 
                85                  90                  95      


Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp Ala Glu 
            100                 105                 110         


Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro Val Phe 
        115                 120                 125             


Gly Lys Gly Ile Ile Ile Glu Asn Ser Lys Thr Thr Phe Leu Thr Pro 
    130                 135                 140                 


Val Ala Thr Glu Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala Phe Pro 
145                 150                 155                 160 


Pro Thr Glu Pro Leu Met Ser Pro Met Thr Leu Asp Asp Met Arg Asp 
                165                 170                 175     


Leu Tyr Lys Asp Asn Lys Tyr Val Lys Asn Leu Asp Glu Leu Thr Leu 
            180                 185                 190         


Cys Ser Arg His Ala Gly Asn Met Ile Pro Asp Asn Asp Lys Asn Ser 
        195                 200                 205             


Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr Glu Asp Lys Lys Cys His 
    210                 215                 220                 


Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr Cys Asn 
225                 230                 235                 240 


Lys Asp Gln Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro Ala Lys 
                245                 250                 255     


Asp Ile Ser Phe Gln Asn Tyr Val Tyr Leu Ser Lys Asn Val Val Asp 
            260                 265                 270         


Asn Trp Glu Lys Val Cys Pro Arg Lys Asn Leu Gln Asn Ala Lys Phe 
        275                 280                 285             


Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val Asn Glu 
    290                 295                 300                 


Phe Ser Ala Ile Asp Leu Phe Glu Cys Asn Lys Leu Val Phe Glu Leu 
305                 310                 315                 320 


Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr Asp Tyr 
                325                 330                 335     


Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met Ile Arg 
            340                 345                 350         


Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr Lys Ser 
        355                 360                 365             


His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Thr Glu Thr Gln Lys 
    370                 375                 380                 


Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp Lys Ser 
385                 390                 395                 400 


Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Asn Glu Val Glu His Asn 
                405                 410                 415     


Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile Lys Lys Glu Ile Glu Arg 
            420                 425                 430         


Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly Asn Lys 
        435                 440                 445             


Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Ile Asp Ser Leu 
    450                 455                 460                 


Lys Cys Pro Cys Ala Pro Glu Ile Val Ser Gln Ser Thr Cys Asn Phe 
465                 470                 475                 480 


Phe Val Cys Lys Cys Val Glu Lys Arg Ala Glu Val Thr Ser Asn Asn 
                485                 490                 495     


Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp Ile Pro 
            500                 505                 510         


Glu His Lys Pro Thr Tyr Asp Lys Met 
        515                 520     


<210>  4
<211>  169
<212>  PRT
<213>  Plasmodium falciparum

<400>  4

Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser 
1               5                   10                  15      


Gly His Leu Glu Cys Lys Cys Glu Asn Asp Leu Val Leu Val Asn Glu 
            20                  25                  30          


Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn 
        35                  40                  45              


Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro 
    50                  55                  60                  


Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn 
65                  70                  75                  80  


Val Cys Ile Pro Asn Glu Cys Lys Asn Val Ala Cys Gly Asn Gly Lys 
                85                  90                  95      


Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys 
            100                 105                 110         


Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp 
        115                 120                 125             


Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Ala Cys 
    130                 135                 140                 


Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile 
145                 150                 155                 160 


Ile Asp Asn Glu Ala Ser Ile Cys Thr 
                165                 


<210>  5
<211>  73
<212>  PRT
<213>  Plasmodium falciparum

<400>  5

Pro Ser Asp Lys His Ile Lys Glu Tyr Leu Asn Lys Ile Gln Asn Ser 
1               5                   10                  15      


Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile 
            20                  25                  30          


Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu 
        35                  40                  45              


Asp Tyr Ala Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys 
    50                  55                  60                  


Ser Ser Val Phe Asn Val Val Asn Ser 
65                  70              


<210>  6
<211>  95
<212>  PRT
<213>  Plasmodium falciparum

<400>  6

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Ala Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn 
                85                  90                  95  


<210>  7
<211>  16
<212>  PRT
<213>  Plasmodium falciparum

<400>  7

Ser Thr Tyr Gly Lys Ala Ile Ala Val Asp Ala Phe Ile Lys Lys Ile 
1               5                   10                  15      


<210>  8
<211>  13
<212>  PRT
<213>  Plasmodium falciparum

<400>  8

Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His 
1               5                   10              


<210>  9
<211>  769
<212>  PRT
<213>  Plasmodium falciparum

<400>  9

Glu Phe Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr 
1               5                   10                  15      


His Pro Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro 
            20                  25                  30          


Leu His Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu 
        35                  40                  45              


Asn Thr Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro 
    50                  55                  60                  


Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg 
65                  70                  75                  80  


Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp 
                85                  90                  95      


Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp 
            100                 105                 110         


Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro 
        115                 120                 125             


Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Gln Thr Thr Phe Leu 
    130                 135                 140                 


Thr Pro Val Ala Thr Glu Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala 
145                 150                 155                 160 


Phe Pro Pro Thr Lys Pro Leu Met Ser Pro Met Thr Leu Asp Gln Met 
                165                 170                 175     


Arg His Phe Tyr Lys Asp Asn Glu Tyr Val Lys Asn Leu Asp Glu Leu 
            180                 185                 190         


Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro Asp Asn Asp Lys 
        195                 200                 205             


Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Asp Lys Asp Lys Lys 
    210                 215                 220                 


Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr 
225                 230                 235                 240 


Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro 
                245                 250                 255     


Ala Lys Asp Lys Ser Phe Gln Asn Tyr Val Tyr Leu Ser Lys Asn Val 
            260                 265                 270         


Val Asp Asn Trp Glu Lys Val Cys Pro Arg Lys Asn Leu Glu Asn Ala 
        275                 280                 285             


Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val 
    290                 295                 300                 


Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn Lys Leu Val Phe 
305                 310                 315                 320 


Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr 
                325                 330                 335     


Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met 
            340                 345                 350         


Ile Arg Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr 
        355                 360                 365             


Lys Ser His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Arg Lys Thr 
    370                 375                 380                 


Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp 
385                 390                 395                 400 


Lys Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Ile Glu Val Glu 
                405                 410                 415     


His Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile Lys Lys Glu Ile 
            420                 425                 430         


Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly 
        435                 440                 445             


Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Lys Asp 
    450                 455                 460                 


Ser Leu Lys Cys Pro Cys Asp Pro Glu Ile Val Ser Gln Ser Thr Cys 
465                 470                 475                 480 


Asn Phe Phe Val Cys Lys Cys Val Glu Lys Arg Ala Glu Val Thr Ser 
                485                 490                 495     


Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp 
            500                 505                 510         


Ile Pro Glu His Lys Pro Thr Tyr Asp Lys Met Ala Ala Val Thr Val 
        515                 520                 525             


Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser Gly His Leu 
    530                 535                 540                 


Glu Cys Lys Cys Glu Asn Asp Leu Val Leu Val Asn Glu Glu Thr Cys 
545                 550                 555                 560 


Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn Lys Pro Cys 
                565                 570                 575     


Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro Val Ser Tyr 
            580                 585                 590         


Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn Val Cys Ile 
        595                 600                 605             


Pro Asn Glu Cys Lys Asn Val Ala Cys Gly Asn Gly Lys Cys Ile Leu 
    610                 615                 620                 


Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys Asn Ile Gly 
625                 630                 635                 640 


Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp Gly Glu Thr 
                645                 650                 655     


Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Ala Cys Lys Ala Val 
            660                 665                 670         


Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile Ile Asp Asn 
        675                 680                 685             


Glu Ala Ser Ile Cys Thr Ala Ala Pro Ser Asp Lys His Ile Lys Glu 
    690                 695                 700                 


Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys 
705                 710                 715                 720 


Ser Val Thr Cys Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser 
                725                 730                 735     


Ala Asn Lys Pro Lys Asp Glu Leu Asp Tyr Ala Asn Asp Ile Glu Lys 
            740                 745                 750         


Lys Ile Cys Lys Met Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn 
        755                 760                 765             


Ser 
    


<210>  10
<211>  791
<212>  PRT
<213>  Plasmodium falciparum

<400>  10

Glu Phe Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr 
1               5                   10                  15      


His Pro Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro 
            20                  25                  30          


Leu His Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu 
        35                  40                  45              


Asn Thr Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro 
    50                  55                  60                  


Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg 
65                  70                  75                  80  


Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp 
                85                  90                  95      


Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp 
            100                 105                 110         


Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro 
        115                 120                 125             


Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Gln Thr Thr Phe Leu 
    130                 135                 140                 


Lys Pro Val Ala Thr Gly Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala 
145                 150                 155                 160 


Phe Pro Pro Thr Asn Pro Leu Ile Ser Pro Met Thr Leu Asn Gly Met 
                165                 170                 175     


Arg Asp Phe Tyr Lys Asn Asn Glu Tyr Val Lys Asn Leu Asp Glu Leu 
            180                 185                 190         


Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro Asp Asn Asp Glu 
        195                 200                 205             


Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr Asn Asp Lys Lys 
    210                 215                 220                 


Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr 
225                 230                 235                 240 


Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro 
                245                 250                 255     


Ala Lys Asp Lys Leu Phe Glu Asn Tyr Val Tyr Leu Ser Lys Asn Val 
            260                 265                 270         


Val His Asn Trp Glu Glu Val Cys Pro Arg Lys Asn Leu Glu Asn Ala 
        275                 280                 285             


Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val 
    290                 295                 300                 


Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn Lys Leu Val Phe 
305                 310                 315                 320 


Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr 
                325                 330                 335     


Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met 
            340                 345                 350         


Ile Arg Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr 
        355                 360                 365             


Lys Ser Arg Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Arg Lys Thr 
    370                 375                 380                 


Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp 
385                 390                 395                 400 


Lys Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Ile Glu Val Glu 
                405                 410                 415     


Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asn Glu Ile Met Lys Glu Ile 
            420                 425                 430         


Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly 
        435                 440                 445             


Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Lys Asp 
    450                 455                 460                 


Ser Leu Lys Cys Pro Cys Asp Pro Glu Met Val Ser Gln Ser Thr Cys 
465                 470                 475                 480 


Arg Phe Phe Val Cys Lys Cys Val Glu Arg Arg Ala Glu Val Thr Ser 
                485                 490                 495     


Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp 
            500                 505                 510         


Ile Pro Glu His Lys Pro Thr Tyr Asp Asn Met Ala Ala Val Thr Val 
        515                 520                 525             


Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser Gly His Leu 
    530                 535                 540                 


Glu Cys Lys Cys Glu Asn Asp Leu Val Leu Val Asn Glu Glu Thr Cys 
545                 550                 555                 560 


Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn Lys Pro Cys 
                565                 570                 575     


Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro Val Ser Tyr 
            580                 585                 590         


Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn Val Cys Ile 
        595                 600                 605             


Pro Asn Glu Cys Lys Asn Val Ala Cys Gly Asn Gly Lys Cys Ile Leu 
    610                 615                 620                 


Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys Asn Ile Gly 
625                 630                 635                 640 


Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp Gly Glu Thr 
                645                 650                 655     


Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Ala Cys Lys Ala Val 
            660                 665                 670         


Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile Ile Asp Asn 
        675                 680                 685             


Glu Ala Ser Ile Cys Thr Ala Ala Ile Ser Gln His Gln Cys Val Lys 
    690                 695                 700                 


Lys Gln Cys Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg 
705                 710                 715                 720 


Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys 
                725                 730                 735     


Val Glu Asn Pro Asn Pro Ala Cys Asn Glu Asn Asn Gly Gly Cys Asp 
            740                 745                 750         


Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys 
        755                 760                 765             


Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly 
    770                 775                 780                 


Ile Phe Cys Ser Ser Ser Asn 
785                 790     


<210>  11
<211>  710
<212>  PRT
<213>  Plasmodium falciparum

<400>  11

Glu Phe Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr 
1               5                   10                  15      


His Pro Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro 
            20                  25                  30          


Leu His Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu 
        35                  40                  45              


Asn Thr Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro 
    50                  55                  60                  


Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg 
65                  70                  75                  80  


Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp 
                85                  90                  95      


Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp 
            100                 105                 110         


Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro 
        115                 120                 125             


Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Lys Thr Thr Phe Leu 
    130                 135                 140                 


Thr Pro Val Ala Thr Glu Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala 
145                 150                 155                 160 


Phe Pro Pro Thr Glu Pro Leu Met Ser Pro Met Thr Leu Asp Asp Met 
                165                 170                 175     


Arg Asp Leu Tyr Lys Asp Asn Lys Tyr Val Lys Asn Leu Asp Glu Leu 
            180                 185                 190         


Thr Leu Cys Ser Arg His Ala Gly Asn Met Ile Pro Asp Asn Asp Lys 
        195                 200                 205             


Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr Glu Asp Lys Lys 
    210                 215                 220                 


Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr 
225                 230                 235                 240 


Cys Asn Lys Asp Gln Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro 
                245                 250                 255     


Ala Lys Asp Ile Ser Phe Gln Asn Tyr Val Tyr Leu Ser Lys Asn Val 
            260                 265                 270         


Val Asp Asn Trp Glu Lys Val Cys Pro Arg Lys Asn Leu Gln Asn Ala 
        275                 280                 285             


Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val 
    290                 295                 300                 


Asn Glu Phe Ser Ala Ile Asp Leu Phe Glu Cys Asn Lys Leu Val Phe 
305                 310                 315                 320 


Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr 
                325                 330                 335     


Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met 
            340                 345                 350         


Ile Arg Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr 
        355                 360                 365             


Lys Ser His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Thr Glu Thr 
    370                 375                 380                 


Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp 
385                 390                 395                 400 


Lys Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Asn Glu Val Glu 
                405                 410                 415     


His Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile Lys Lys Glu Ile 
            420                 425                 430         


Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly 
        435                 440                 445             


Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Ile Asp 
    450                 455                 460                 


Ser Leu Lys Cys Pro Cys Ala Pro Glu Ile Val Ser Gln Ser Thr Cys 
465                 470                 475                 480 


Asn Phe Phe Val Cys Lys Cys Val Glu Lys Arg Ala Glu Val Thr Ser 
                485                 490                 495     


Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp 
            500                 505                 510         


Ile Pro Glu His Lys Pro Thr Tyr Asp Lys Met Ala Ala Val Thr Val 
        515                 520                 525             


Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser Gly His Leu 
    530                 535                 540                 


Glu Cys Lys Cys Glu Asn Asp Leu Val Leu Val Asn Glu Glu Thr Cys 
545                 550                 555                 560 


Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn Lys Pro Cys 
                565                 570                 575     


Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro Val Ser Tyr 
            580                 585                 590         


Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn Val Cys Ile 
        595                 600                 605             


Pro Asn Glu Cys Lys Asn Val Ala Cys Gly Asn Gly Lys Cys Ile Leu 
    610                 615                 620                 


Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys Asn Ile Gly 
625                 630                 635                 640 


Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp Gly Glu Thr 
                645                 650                 655     


Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Ala Cys Lys Ala Val 
            660                 665                 670         


Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile Ile Asp Asn 
        675                 680                 685             


Glu Ala Ser Ile Cys Thr Ser Thr Tyr Gly Lys Ala Ile Ala Val Asp 
    690                 695                 700                 


Ala Phe Ile Lys Lys Ile 
705                 710 


<210>  12
<211>  707
<212>  PRT
<213>  Plasmodium falciparum

<400>  12

Glu Phe Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr 
1               5                   10                  15      


His Pro Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro 
            20                  25                  30          


Leu His Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu 
        35                  40                  45              


Asn Thr Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro 
    50                  55                  60                  


Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg 
65                  70                  75                  80  


Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp 
                85                  90                  95      


Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp 
            100                 105                 110         


Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro 
        115                 120                 125             


Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Lys Thr Thr Phe Leu 
    130                 135                 140                 


Thr Pro Val Ala Thr Glu Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala 
145                 150                 155                 160 


Phe Pro Pro Thr Glu Pro Leu Met Ser Pro Met Thr Leu Asp Asp Met 
                165                 170                 175     


Arg Asp Leu Tyr Lys Asp Asn Lys Tyr Val Lys Asn Leu Asp Glu Leu 
            180                 185                 190         


Thr Leu Cys Ser Arg His Ala Gly Asn Met Ile Pro Asp Asn Asp Lys 
        195                 200                 205             


Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr Glu Asp Lys Lys 
    210                 215                 220                 


Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr 
225                 230                 235                 240 


Cys Asn Lys Asp Gln Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro 
                245                 250                 255     


Ala Lys Asp Ile Ser Phe Gln Asn Tyr Val Tyr Leu Ser Lys Asn Val 
            260                 265                 270         


Val Asp Asn Trp Glu Lys Val Cys Pro Arg Lys Asn Leu Gln Asn Ala 
        275                 280                 285             


Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val 
    290                 295                 300                 


Asn Glu Phe Ser Ala Ile Asp Leu Phe Glu Cys Asn Lys Leu Val Phe 
305                 310                 315                 320 


Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr 
                325                 330                 335     


Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met 
            340                 345                 350         


Ile Arg Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr 
        355                 360                 365             


Lys Ser His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Thr Glu Thr 
    370                 375                 380                 


Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp 
385                 390                 395                 400 


Lys Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Asn Glu Val Glu 
                405                 410                 415     


His Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile Lys Lys Glu Ile 
            420                 425                 430         


Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly 
        435                 440                 445             


Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Ile Asp 
    450                 455                 460                 


Ser Leu Lys Cys Pro Cys Ala Pro Glu Ile Val Ser Gln Ser Thr Cys 
465                 470                 475                 480 


Asn Phe Phe Val Cys Lys Cys Val Glu Lys Arg Ala Glu Val Thr Ser 
                485                 490                 495     


Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp 
            500                 505                 510         


Ile Pro Glu His Lys Pro Thr Tyr Asp Lys Met Ala Ala Val Thr Val 
        515                 520                 525             


Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser Gly His Leu 
    530                 535                 540                 


Glu Cys Lys Cys Glu Asn Asp Leu Val Leu Val Asn Glu Glu Thr Cys 
545                 550                 555                 560 


Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn Lys Pro Cys 
                565                 570                 575     


Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro Val Ser Tyr 
            580                 585                 590         


Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn Val Cys Ile 
        595                 600                 605             


Pro Asn Glu Cys Lys Asn Val Ala Cys Gly Asn Gly Lys Cys Ile Leu 
    610                 615                 620                 


Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys Asn Ile Gly 
625                 630                 635                 640 


Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp Gly Glu Thr 
                645                 650                 655     


Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Ala Cys Lys Ala Val 
            660                 665                 670         


Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile Ile Asp Asn 
        675                 680                 685             


Glu Ala Ser Ile Cys Thr Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu 
    690                 695                 700                 


Tyr Ile His 
705         


