                         SEQUENCE LISTING

<110>  The Research Foundation of State University of New York 
       SUNY at Stony Brook
       Wimmer, Eckard
       Mueller, Steffen
       Futcher, Bruce
       Shen, Sam
       Stauft, Charles
       Ward, Charles
 
<120>  RECODED ARBOVIRUS AND VACCINES

<130>  14421/495p2

<140>  not assigned
<141>  2014-09-12

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  10723
<212>  DNA
<213>  Dengue virus

<400>  1
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaacgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acacgtaacg gagaaccaca catgatcgtc      480

agcagacaag agaaagggaa aagtcttctg tttaaaacag aggatggcgt gaacatgtgt      540

accctcatgg ccatggacct tggtgaattg tgtgaagaca caatcacgta caagtgtccc      600

cttctcaggc agaatgagcc agaagacata gactgttggt gcaactctac gtccacgtgg      660

gtaacttatg ggacgtgtac caccatggga gaacatagaa gagaaaaaag atcagtggca      720

ctcgttccac atgtgggaat gggactggag acacgaactg aaacatggat gtcatcagaa      780

ggggcctgga aacatgtcca gagaattgaa acttggatct tgagacatcc aggcttcacc      840

atgatggcag caatcctggc atacaccata ggaacgacac atttccaaag agccctgatt      900

ttcatcttac tgacagctgt cactccttca atgacaatgc gttgcatagg aatgtcaaat      960

agagactttg tggaaggggt ttcaggagga agctgggttg acatagtctt agaacatgga     1020

agctgtgtga cgacgatggc aaaaaacaaa ccaacattgg attttgaact gataaaaaca     1080

gaagccaaac agcctgccac cctaaggaag tactgtatag aggcaaagct aaccaacaca     1140

acaacagaat ctcgctgccc aacacaaggg gaacccagcc taaatgaaga gcaggacaaa     1200

aggttcgtct gcaaacactc catggtagac agaggatggg gaaatggatg tggactattt     1260

ggaaagggag gcattgtgac ctgtgctatg ttcagatgca aaaagaacat ggaaggaaaa     1320

gttgtgcaac cagaaaactt ggaatacacc attgtgataa cacctcactc aggggaagag     1380

catgcagtcg gaaatgacac aggaaaacat ggcaaggaaa tcaaaataac accacagagt     1440

tccatcacag aagcagaatt gacaggttat ggcactgtca caatggagtg ctctccaaga     1500

acgggcctcg acttcaatga gatggtgttg ctgcagatgg aaaataaagc ttggctggtg     1560

cacaggcaat ggttcctaga cctgccgtta ccatggttgc ccggagcgga cacacaaggg     1620

tcaaattgga tacagaaaga gacattggtc actttcaaaa atccccatgc gaagaaacag     1680

gatgttgttg ttttaggatc ccaagaaggg gccatgcaca cagcacttac aggggccaca     1740

gaaatccaaa tgtcatcagg aaacttactc ttcacaggac atctcaagtg caggctgaga     1800

atggacaagc tacagctcaa aggaatgtca tactctatgt gcacaggaaa gtttaaagtt     1860

gtgaaggaaa tagcagaaac acaacatgga acaatagtta tcagagtgca atatgaaggg     1920

gacggctctc catgcaagat cccttttgag ataatggatt tggaaaaaag acatgtctta     1980

ggtcgcctga ttacagtcaa cccaattgtg acagaaaaag atagcccagt caacatagaa     2040

gcagaacctc cattcggaga cagctacatc atcataggag tagagccggg acaactgaag     2100

ctcaactggt ttaagaaagg aagttctatc ggccaaatgt ttgagacaac aatgaggggg     2160

gcgaagagaa tggccatttt aggtgacaca gcctgggatt ttggatcctt gggaggagtg     2220

tttacatcta taggaaaggc tctccaccaa gtctttggag caatctatgg agctgccttc     2280

agtggggttt catggactat gaaaatcctc ataggagtca ttatcacatg gataggaatg     2340

aattcacgca gcacctcact gtctgtgaca ctagtattgg tgggaattgt gacactgtat     2400

ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa caaagaactg     2460

aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag     2520

ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca tgaagagggc     2580

atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca     2640

gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc     2700

aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat     2760

tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt     2820

ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg     2880

gaagttgaag actatggctt tggagtattc accaccaata tatggctaaa attgaaagaa     2940

aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc     3000

gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag     3060

aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc     3120

aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa     3180

cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagctt     3240

gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat     3300

agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc     3360

cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg     3420

gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga     3480

catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa     3540

atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg     3600

acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc     3660

gccactatga cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc     3720

aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc caaggaattg     3780

atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga gaccattctt     3840

gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa     3900

aagtatcaat tggcagtgac tatcatggct atcttgtgcg tcccaaacgc agtgatatta     3960

caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgctc     4020

ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc     4080

aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca     4140

ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa     4200

aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt gtgctacgtg     4260

ctcactggac gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac     4320

caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc     4380

atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag aacaggattg     4440

ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg     4500

tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc cccacccatg     4560

ggaaaggctg aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat     4620

tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca     4680

cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag     4740

aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa     4800

gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca aacgaaacct     4860

ggtcttttca aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga     4920

acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt     4980

gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa     5040

gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc     5100

cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga agctataaaa     5160

cggggtttga gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa     5220

gcccttagag gacttccaat aagataccag accccagcca tcagagctga gcacaccggg     5280

cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt     5340

agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga cccagcaagt     5400

atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc tgggattttt     5460

atgacagcca ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata     5520

gatgaagaaa gagaaatccc tgaacgttcg tggaattccg gacatgaatg ggtcacggat     5580

tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct     5640

tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag     5700

tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat ttcagaaatg     5760

ggtgccaatt tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata     5820

ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt     5880

gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata     5940

tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg     6000

ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga accagagcgt     6060

gaaaaggtgg atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt     6120

gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa     6180

ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta     6240

gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc     6300

agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt taaggaattt     6360

gcagccggaa gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc     6420

ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag     6480

gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg     6540

cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgga     6600

aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggctag catcctccta     6660

tggtacgcac aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc     6720

atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc     6780

tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc     6840

ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc     6900

aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc cgtggccaca     6960

acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta     7020

acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca     7080

aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata     7140

actctcacag cagctctttt cttattggta gcacattatg ccatcatagg gccaggactc     7200

caagcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca     7260

actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa     7320

aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg     7380

actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc cacattgtgg     7440

gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt     7500

agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac     7560

acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg     7620

aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat     7680

agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc tgtgtcgcga     7740

ggctcagcaa aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta     7800

gtggacctcg gttgtggcag aggaggctgg tcatactatt gtggaggact aaagaatgta     7860

agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca     7920

acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca     7980

gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc cacagtggaa     8040

gcaggacgaa cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa     8100

ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta     8160

caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag     8220

atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg     8280

atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc ggatgttgac     8340

ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt     8400

gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac     8460

cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca     8520

tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg     8580

gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt ttttaaagag     8640

aaagtggaca cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca     8700

gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa     8760

gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac     8820

aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag     8880

gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa     8940

agagagaaga agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg     9000

tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg     9060

ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac     9120

attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga     9180

tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac aaaccacatg     9240

gaaggagaac acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg     9300

gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac     9360

caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc     9420

caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc     9480

acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga     9540

atggccatca gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct     9600

ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca     9660

agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc     9720

atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact gattggcaga     9780

gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt ggggaagtct     9840

tacgcccaaa tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat     9900

gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgaacaac ctggtccata     9960

catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg    10020

attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca    10080

tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac aagcagggcc    10140

acctgggcaa agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa    10200

gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga    10260

gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc    10320

catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca    10380

ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg    10440

tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc    10500

ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga    10560

agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag    10620

catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca    10680

gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct                      10723


<210>  2
<211>  10723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Accession #U87411 containing new restriction sites

<400>  2
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaacgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acacgtaacg gagaaccaca catgatcgtc      480

agcagacaag agaaagggaa aagtcttctg tttaaaacag aggatggcgt gaacatgtgt      540

accctcatgg ccatggacct tggtgaattg tgtgaagaca caatcacgta caagtgtccc      600

cttctcaggc agaatgagcc agaagacata gactgttggt gcaactctac gtccacgtgg      660

gtaacttatg ggacgtgtac caccatggga gaacatagaa gagaaaaaag atcagtggca      720

ctcgttccac atgtgggaat gggactggag acgcgtactg aaacatggat gtcatcagaa      780

ggggcctgga aacatgtcca gagaattgaa acttggatct tgagacatcc aggcttcacc      840

atgatggcag caatcctggc atacaccata ggaacgacac atttccaaag agccctgatt      900

ttcatcttac tgacagctgt cactccttca atgacaatgc gttgcatagg aatgtcaaat      960

agagactttg tggaaggggt ttcaggagga agctgggttg acatagtctt agaacatgga     1020

agctgtgtga cgacgatggc aaaaaacaaa ccaacattgg attttgaact gataaaaaca     1080

gaagccaaac agcctgccac cctaaggaag tactgtatag aggcaaagct aaccaacaca     1140

acaacagaat ctcgctgccc aacacaaggg gaacccagcc taaatgaaga gcaggacaaa     1200

aggttcgtct gcaaacactc catggtagac agaggatggg gaaatggatg tggactattt     1260

ggaaagggag gcattgtgac ctgtgctatg ttcagatgca aaaagaacat ggaaggaaaa     1320

gttgtgcaac cagaaaactt ggaatacacc attgtgataa cacctcactc aggggaagaa     1380

catgcagtcg gaaatgacac aggaaaacat ggcaaggaaa tcaaaataac accacagagt     1440

tccatcacag aagcagaatt gacaggttat ggcactgtca caatggagtg ctctccaaga     1500

acgggcctcg acttcaatga gatggtgttg ctgcagatgg aaaataaggc ttggctggtg     1560

cacaggcaat ggttcctaga cctgccgtta ccatggttgc ccggagcgga cacacaaggg     1620

tcaaattgga tacagaaaga gacattggtc actttcaaaa atccccatgc gaagaaacag     1680

gatgttgttg ttttaggatc ccaagaaggg gccatgcaca cagcacttac aggggccaca     1740

gaaatccaaa tgagctcagg aaacttactc ttcacaggac atctcaagtg caggctgaga     1800

atggacaagc tacagctcaa aggaatgtca tactctatgt gcacaggaaa gtttaaagtt     1860

gtgaaggaaa tagcagaaac acaacatgga acaatagtta tcagagtgca atatgaaggg     1920

gacggctctc catgcaagat cccttttgag ataatggatt tggaaaaaag acatgtctta     1980

ggtcgcctga ttacagtcaa cccaattgtg acagaaaaag atagcccagt caacatagaa     2040

gcagaacctc cattcggaga cagctacatc atcataggag tagagccggg acaactgaag     2100

ctcaactggt ttaagaaagg aagttctatc ggccaaatgt ttgagacaac aatgaggggg     2160

gcgaagagaa tggccatttt aggtgacaca gcctgggatt ttggatcctt gggaggagtg     2220

tttacatcta taggaaaggc tctccaccaa gtctttggag caatctatgg agctgccttc     2280

agtggggttt catggactat gaaaatcctc ataggagtca ttatcacatg gataggaatg     2340

aattcacgca gcacctcact gtctgtgaca ttagtattgg tgggaattgt gacactgtat     2400

ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa caaagaactg     2460

aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag     2520

ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca tgaagagggc     2580

atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca     2640

gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc     2700

aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat     2760

tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt     2820

ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg     2880

gaagttgaag actatggctt tggagtattc accaccaata tatggcttaa gttgaaagaa     2940

aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc     3000

gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag     3060

aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc     3120

aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa     3180

cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagcta     3240

gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat     3300

agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc     3360

cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg     3420

gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga     3480

catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa     3540

atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg     3600

acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc     3660

gccactatga cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc     3720

aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc caaggaattg     3780

atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga gaccattctt     3840

gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa     3900

aagtatcagt tggcagtgac tatcatggct atcttgtgcg tcccaaacgc agtgatatta     3960

caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgctc     4020

ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc     4080

aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca     4140

ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa     4200

aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt gtgctacgtg     4260

ctcactggac gatcggcaga tttggaactg gagagagcag ccgatgtcaa atgggaagac     4320

caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc     4380

atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag aaccggtttg     4440

ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg     4500

tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc cccacccatg     4560

ggaaaggctg aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat     4620

tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca     4680

cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag     4740

aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa     4800

gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca aacgaaacct     4860

ggtcttttca aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga     4920

acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt     4980

gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa     5040

gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc     5100

cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga agctataaaa     5160

cggggtttga gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa     5220

gcccttagag gacttccaat aagataccag accccagcca tcagagctga gcacaccggg     5280

cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt     5340

agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga cccagcaagt     5400

atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc tgggattttt     5460

atgacagcca ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata     5520

gatgaagaaa gagaaatccc tgaacgttcg tggaattccg gtcatgaatg ggtcacggat     5580

tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct     5640

tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag     5700

tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat ttcagaaatg     5760

ggtgccaatt tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata     5820

ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt     5880

gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata     5940

tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg     6000

ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga accagagcgt     6060

gaaaaggtgg atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt     6120

gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa     6180

ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta     6240

gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc     6300

agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt taaggaattt     6360

gcagccggaa gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc     6420

ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag     6480

gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg     6540

cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgga     6600

aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggcaag catcctccta     6660

tggtacgcac aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc     6720

atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc     6780

tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc     6840

ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc     6900

aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc cgtggccaca     6960

acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta     7020

acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca     7080

aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata     7140

actctcacag cagctctttt cttattggta gcacattatg ccatcatagg gcctggcctg     7200

caggcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca     7260

actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa     7320

aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg     7380

actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc cacattgtgg     7440

gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt     7500

agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac     7560

acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg     7620

aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat     7680

agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc tgtgtcgcgt     7740

ggctcagcaa aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta     7800

gtggacctcg gttgtggccg cggaggctgg tcatactatt gtggaggact aaagaatgta     7860

agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca     7920

acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca     7980

gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc cacagtggaa     8040

gcaggacgaa cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa     8100

ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta     8160

caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag     8220

atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg     8280

atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc ggatgttgac     8340

ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt     8400

gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac     8460

cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca     8520

tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg     8580

gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt ttttaaagag     8640

aaagtggaca cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca     8700

gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa     8760

gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac     8820

aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag     8880

gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa     8940

agagagaaga agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg     9000

tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg     9060

ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac     9120

attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga     9180

tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac aaaccacatg     9240

gaaggagaac acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg     9300

gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac     9360

caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc     9420

caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc     9480

acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga     9540

atggccatca gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct     9600

ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca     9660

agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc     9720

atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact gattggcaga     9780

gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt ggggaagtct     9840

tacgcccaaa tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat     9900

gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgtacgac ctggtccata     9960

catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg    10020

attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca    10080

tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac aagcagggcc    10140

acctgggcaa agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa    10200

gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga    10260

gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc    10320

catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca    10380

ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg    10440

tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc    10500

ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga    10560

agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag    10620

catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca    10680

gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct                      10723


<210>  3
<211>  10723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recoded E


<220>
<221>  misc_feature
<222>  (937)..(2421)
<223>  deoptimized region

<400>  3
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaacgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acacgtaacg gagaaccaca catgatcgtc      480

agcagacaag agaaagggaa aagtcttctg tttaaaacag aggatggcgt gaacatgtgt      540

accctcatgg ccatggacct tggtgaattg tgtgaagaca caatcacgta caagtgtccc      600

cttctcaggc agaatgagcc agaagacata gactgttggt gcaactctac gtccacgtgg      660

gtaacttatg ggacgtgtac caccatggga gaacatagaa gagaaaaaag atcagtggca      720

ctcgttccac atgtgggaat gggactggag acgcgtactg aaacatggat gtcatcagaa      780

ggggcctgga aacatgtcca gagaattgaa acttggatct tgagacatcc aggcttcacc      840

atgatggcag caatcctggc atacaccata ggaacgacac atttccaaag agccctgatt      900

ttcatcttac tgacagctgt cactccttca atgacaatga gatgcatagg aatgagcaac      960

cgcgatttcg tcgaaggcgt ttccggaggg agttgggtcg acatagtgct cgaacacgga     1020

tcttgcgtta ccacaatggc caaaaataaa ccaacactcg actttgaact cataaaaacc     1080

gaagctaagc aaccggcaac acttaggaag tattgtatcg aagcgaaatt gactaacaca     1140

acaacagagt ctaggtgtcc aacacaaggc gaacctagct tgaacgaaga gcaagacaaa     1200

agattcgttt gcaaacattc tatggtcgat cgcggatggg gaaacggatg cggattgttc     1260

ggaaaggggg gaatcgttac atgcgctatg ttcagatgca aaaaaaacat ggagggaaag     1320

gtcgtgcaac ccgaaaatct ggagtataca atcgttataa caccacattc cggcgaagag     1380

catgccgtcg gaaacgacac gggtaagcac ggtaaggaaa tcaaaattac acctcaatct     1440

agcataaccg aagccgaact gacagggtac ggaacagtga caatggaatg ctcacctaga     1500

acagggttgg acttcaacga aatggtgcta ctgcaaatgg agaataaggc atggttagtg     1560

cataggcaat ggtttctcga tctgccacta ccatggttac ccggagccga tacacaggga     1620

tctaattgga tacagaagga aacattggtg acatttaaaa acccacacgc aaaaaaacag     1680

gacgtcgtcg ttctcggatc acaggaaggg gcaatgcata cagccctaac cggagcaacc     1740

gaaattcaga tgagctcagg gaatctatta tttacgggac atctgaaatg tagattgcgt     1800

atggacaaac tgcagttgaa gggaatgagc tattctatgt gtacaggtaa gtttaaggtc     1860

gttaaggaga tagccgaaac gcaacacgga acaatcgtaa ttagggtgca atacgaaggc     1920

gacggatcac cttgcaaaat accgtttgaa attatggacc tcgaaaaaag acacgtactc     1980

ggaagactga taacagtcaa tccaattgtg acagagaagg actcaccagt gaatatcgaa     2040

gccgaaccac cattcggaga tagctatatt ataatcggag tcgaacccgg acagttgaaa     2100

ctgaattggt ttaaaaaggg atcatcaatc ggacagatgt ttgaaacaac aatgcgcgga     2160

gcgaaaagaa tggcaatatt aggcgacact gcttgggact tcgggagctt agggggagtg     2220

tttacatcaa tcggaaaggc actacatcaa gtgttcggag cgatatacgg agccgcattt     2280

tccggagtga gttggactat gaagatactg ataggggtga taattacatg gatcggaatg     2340

aatagtaggt ctacatcact atccgttaca ttggtgttag tcggaatcgt tacattgtac     2400

ttaggcgtaa tggtgcaagc tgatagtggt tgcgttgtga gctggaaaaa caaagaactg     2460

aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag     2520

ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca tgaagagggc     2580

atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca     2640

gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc     2700

aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat     2760

tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt     2820

ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg     2880

gaagttgaag actatggctt tggagtattc accaccaata tatggcttaa gttgaaagaa     2940

aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc     3000

gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag     3060

aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc     3120

aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa     3180

cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagcta     3240

gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat     3300

agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc     3360

cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg     3420

gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga     3480

catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa     3540

atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg     3600

acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc     3660

gccactatga cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc     3720

aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc caaggaattg     3780

atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga gaccattctt     3840

gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa     3900

aagtatcagt tggcagtgac tatcatggct atcttgtgcg tcccaaacgc agtgatatta     3960

caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgctc     4020

ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc     4080

aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca     4140

ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa     4200

aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt gtgctacgtg     4260

ctcactggac gatcggcaga tttggaactg gagagagcag ccgatgtcaa atgggaagac     4320

caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc     4380

atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag aaccggtttg     4440

ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg     4500

tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc cccacccatg     4560

ggaaaggctg aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat     4620

tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca     4680

cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag     4740

aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa     4800

gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca aacgaaacct     4860

ggtcttttca aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga     4920

acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt     4980

gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa     5040

gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc     5100

cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga agctataaaa     5160

cggggtttga gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa     5220

gcccttagag gacttccaat aagataccag accccagcca tcagagctga gcacaccggg     5280

cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt     5340

agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga cccagcaagt     5400

atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc tgggattttt     5460

atgacagcca ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata     5520

gatgaagaaa gagaaatccc tgaacgttcg tggaattccg gtcatgaatg ggtcacggat     5580

tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct     5640

tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag     5700

tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat ttcagaaatg     5760

ggtgccaatt tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata     5820

ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt     5880

gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata     5940

tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg     6000

ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga accagagcgt     6060

gaaaaggtgg atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt     6120

gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa     6180

ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta     6240

gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc     6300

agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt taaggaattt     6360

gcagccggaa gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc     6420

ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag     6480

gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg     6540

cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgga     6600

aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggcaag catcctccta     6660

tggtacgcac aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc     6720

atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc     6780

tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc     6840

ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc     6900

aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc cgtggccaca     6960

acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta     7020

acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca     7080

aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata     7140

actctcacag cagctctttt cttattggta gcacattatg ccatcatagg gcctggcctg     7200

caggcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca     7260

actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa     7320

aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg     7380

actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc cacattgtgg     7440

gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt     7500

agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac     7560

acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg     7620

aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat     7680

agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc tgtgtcgcgt     7740

ggctcagcaa aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta     7800

gtggacctcg gttgtggccg cggaggctgg tcatactatt gtggaggact aaagaatgta     7860

agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca     7920

acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca     7980

gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc cacagtggaa     8040

gcaggacgaa cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa     8100

ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta     8160

caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag     8220

atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg     8280

atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc ggatgttgac     8340

ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt     8400

gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac     8460

cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca     8520

tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg     8580

gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt ttttaaagag     8640

aaagtggaca cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca     8700

gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa     8760

gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac     8820

aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag     8880

gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa     8940

agagagaaga agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg     9000

tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg     9060

ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac     9120

attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga     9180

tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac aaaccacatg     9240

gaaggagaac acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg     9300

gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac     9360

caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc     9420

caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc     9480

acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga     9540

atggccatca gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct     9600

ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca     9660

agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc     9720

atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact gattggcaga     9780

gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt ggggaagtct     9840

tacgcccaaa tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat     9900

gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgtacgac ctggtccata     9960

catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg    10020

attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca    10080

tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac aagcagggcc    10140

acctgggcaa agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa    10200

gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga    10260

gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc    10320

catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca    10380

ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg    10440

tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc    10500

ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga    10560

agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag    10620

catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca    10680

gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct                      10723


<210>  4
<211>  10723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recoded NS3


<220>
<221>  misc_feature
<222>  (4522)..(6375)
<223>  deoptimized region

<400>  4
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaacgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acacgtaacg gagaaccaca catgatcgtc      480

agcagacaag agaaagggaa aagtcttctg tttaaaacag aggatggcgt gaacatgtgt      540

accctcatgg ccatggacct tggtgaattg tgtgaagaca caatcacgta caagtgtccc      600

cttctcaggc agaatgagcc agaagacata gactgttggt gcaactctac gtccacgtgg      660

gtaacttatg ggacgtgtac caccatggga gaacatagaa gagaaaaaag atcagtggca      720

ctcgttccac atgtgggaat gggactggag acgcgtactg aaacatggat gtcatcagaa      780

ggggcctgga aacatgtcca gagaattgaa acttggatct tgagacatcc aggcttcacc      840

atgatggcag caatcctggc atacaccata ggaacgacac atttccaaag agccctgatt      900

ttcatcttac tgacagctgt cactccttca atgacaatgc gttgcatagg aatgtcaaat      960

agagactttg tggaaggggt ttcaggagga agctgggttg acatagtctt agaacatgga     1020

agctgtgtga cgacgatggc aaaaaacaaa ccaacattgg attttgaact gataaaaaca     1080

gaagccaaac agcctgccac cctaaggaag tactgtatag aggcaaagct aaccaacaca     1140

acaacagaat ctcgctgccc aacacaaggg gaacccagcc taaatgaaga gcaggacaaa     1200

aggttcgtct gcaaacactc catggtagac agaggatggg gaaatggatg tggactattt     1260

ggaaagggag gcattgtgac ctgtgctatg ttcagatgca aaaagaacat ggaaggaaaa     1320

gttgtgcaac cagaaaactt ggaatacacc attgtgataa cacctcactc aggggaagaa     1380

catgcagtcg gaaatgacac aggaaaacat ggcaaggaaa tcaaaataac accacagagt     1440

tccatcacag aagcagaatt gacaggttat ggcactgtca caatggagtg ctctccaaga     1500

acgggcctcg acttcaatga gatggtgttg ctgcagatgg aaaataaggc ttggctggtg     1560

cacaggcaat ggttcctaga cctgccgtta ccatggttgc ccggagcgga cacacaaggg     1620

tcaaattgga tacagaaaga gacattggtc actttcaaaa atccccatgc gaagaaacag     1680

gatgttgttg ttttaggatc ccaagaaggg gccatgcaca cagcacttac aggggccaca     1740

gaaatccaaa tgagctcagg aaacttactc ttcacaggac atctcaagtg caggctgaga     1800

atggacaagc tacagctcaa aggaatgtca tactctatgt gcacaggaaa gtttaaagtt     1860

gtgaaggaaa tagcagaaac acaacatgga acaatagtta tcagagtgca atatgaaggg     1920

gacggctctc catgcaagat cccttttgag ataatggatt tggaaaaaag acatgtctta     1980

ggtcgcctga ttacagtcaa cccaattgtg acagaaaaag atagcccagt caacatagaa     2040

gcagaacctc cattcggaga cagctacatc atcataggag tagagccggg acaactgaag     2100

ctcaactggt ttaagaaagg aagttctatc ggccaaatgt ttgagacaac aatgaggggg     2160

gcgaagagaa tggccatttt aggtgacaca gcctgggatt ttggatcctt gggaggagtg     2220

tttacatcta taggaaaggc tctccaccaa gtctttggag caatctatgg agctgccttc     2280

agtggggttt catggactat gaaaatcctc ataggagtca ttatcacatg gataggaatg     2340

aattcacgca gcacctcact gtctgtgaca ttagtattgg tgggaattgt gacactgtat     2400

ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa caaagaactg     2460

aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag     2520

ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca tgaagagggc     2580

atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca     2640

gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc     2700

aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat     2760

tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt     2820

ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg     2880

gaagttgaag actatggctt tggagtattc accaccaata tatggcttaa gttgaaagaa     2940

aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc     3000

gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag     3060

aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc     3120

aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa     3180

cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagcta     3240

gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat     3300

agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc     3360

cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg     3420

gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga     3480

catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa     3540

atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg     3600

acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc     3660

gccactatga cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc     3720

aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc caaggaattg     3780

atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga gaccattctt     3840

gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa     3900

aagtatcagt tggcagtgac tatcatggct atcttgtgcg tcccaaacgc agtgatatta     3960

caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgctc     4020

ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc     4080

aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca     4140

ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa     4200

aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt gtgctacgtg     4260

ctcactggac gatcggcaga tttggaactg gagagagcag ccgatgtcaa atgggaagac     4320

caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc     4380

atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag aaccggtttg     4440

ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg     4500

tgggaagtga agaaacaacg ggccggagtt ttatgggacg ttccatctcc accaccaatg     4560

ggtaaggccg agctggaaga cggagcatat cggatcaaac agaagggaat actagggtat     4620

tctcaaatcg gagccggagt gtacaaagaa ggaacctttc atacaatgtg gcacgttact     4680

aggggagccg tactgatgca caagggtaag agaatcgaac ctagttgggc agacgttaag     4740

aaagacctaa tctcatacgg aggaggatgg aaactggaag gcgaatggaa agagggagaa     4800

gaggtgcagg tgcttgcact cgaacccggt aagaatccta gagcagtgca aacgaaaccc     4860

ggtctattca aaactaatgc cggaacaatc ggtgccgtaa gtttggactt tagtccagga     4920

actagcggat caccaattat cgacaaaaag ggtaaggtcg tcggattgta cggtaacgga     4980

gtcgttacga gatctggagc atacgttagc gctatagcgc aaaccgaaaa gtcaatcgaa     5040

gacaatcccg aaatcgaaga cgacattttt agaaaaagaa ggttaacgat tatggaccta     5100

catcccggag ccggtaagac taaacggtat ctgccagcaa tcgtgcgcga agcaatcaaa     5160

agggggttga gaacattgat tctagctcct actagggtag tcgcagccga gatggaagaa     5220

gcacttaggg ggttgccaat tagatatcag acacctgcta ttagggccga acataccgga     5280

agagagatag tcgatctgat gtgtcacgct acatttacga tgcgattgct atcaccagtt     5340

agagtgccta attacaatct gataattatg gacgaagcgc attttaccga tccagctagt     5400

atagccgcta ggggatacat atctactcga gtggaaatgg gcgaagctgc cggaattttt     5460

atgaccgcta cacctccagg atcaagagac ccatttccac aatctaacgc tccaattatc     5520

gacgaggaaa gagaaatacc ggagcggtca tggaattccg gacacgaatg ggttaccgat     5580

tttaagggta agaccgtttg gttcgtacct agtatcaaag ccggaaacga tatcgctgca     5640

tgccttagaa aaaacggtaa gaaagtgata cagctatcga gaaagacatt cgatagcgaa     5700

tacgttaaga ctagaacaaa cgattgggat ttcgtcgtta caaccgatat tagcgaaatg     5760

ggagctaatt ttaaggccga aagggtgatt gatcctagaa gatgtatgaa accagtgata     5820

cttaccgacg gagaggaaag agtgatacta gccggaccaa tgccagttac gcattctagt     5880

gcagctcaac gtagagggag aatcggacgt aatccgaaaa acgaaaacga tcagtatata     5940

tacatgggcg aaccactcga aaacgacgag gattgcgcac attggaagga agcgaaaatg     6000

ctattagaca atatcaatac acccgaaggg attataccat caatgttcga acccgagcgc     6060

gaaaaggtcg acgcaatcga cggagaatat agacttagag gcgaagctag aaagacattc     6120

gtcgatctga tgagaagggg ggatctgcca gtttggttgg catacagagt ggcagccgag     6180

gggataaact acgccgatag aagatggtgt ttcgacggag tgaaaaataa tcagatactc     6240

gaagaaaacg tcgaagtcga aatttggaca aaagaaggag aacgtaaaaa actgaaacct     6300

agatggttgg acgctaggat atattccgat ccacttgcac tgaaagaatt taaagagttc     6360

gcagccggaa gaaaatctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc     6420

ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag     6480

gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg     6540

cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgga     6600

aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggcaag catcctccta     6660

tggtacgcac aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc     6720

atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc     6780

tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc     6840

ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc     6900

aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc cgtggccaca     6960

acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta     7020

acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca     7080

aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata     7140

actctcacag cagctctttt cttattggta gcacattatg ccatcatagg gcctggcctg     7200

caggcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca     7260

actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa     7320

aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg     7380

actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc cacattgtgg     7440

gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt     7500

agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac     7560

acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg     7620

aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat     7680

agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc tgtgtcgcgt     7740

ggctcagcaa aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta     7800

gtggacctcg gttgtggccg cggaggctgg tcatactatt gtggaggact aaagaatgta     7860

agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca     7920

acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca     7980

gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc cacagtggaa     8040

gcaggacgaa cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa     8100

ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta     8160

caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag     8220

atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg     8280

atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc ggatgttgac     8340

ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt     8400

gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac     8460

cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca     8520

tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg     8580

gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt ttttaaagag     8640

aaagtggaca cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca     8700

gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa     8760

gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac     8820

aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag     8880

gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa     8940

agagagaaga agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg     9000

tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg     9060

ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac     9120

attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga     9180

tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac aaaccacatg     9240

gaaggagaac acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg     9300

gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac     9360

caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc     9420

caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc     9480

acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga     9540

atggccatca gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct     9600

ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca     9660

agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc     9720

atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact gattggcaga     9780

gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt ggggaagtct     9840

tacgcccaaa tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat     9900

gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgtacgac ctggtccata     9960

catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg    10020

attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca    10080

tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac aagcagggcc    10140

acctgggcaa agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa    10200

gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga    10260

gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc    10320

catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca    10380

ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg    10440

tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc    10500

ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga    10560

agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag    10620

catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca    10680

gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct                      10723


<210>  5
<211>  10723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recoded NS5


<220>
<221>  misc_feature
<222>  (7570)..(10269)
<223>  deoptimized region

<400>  5
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaacgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acacgtaacg gagaaccaca catgatcgtc      480

agcagacaag agaaagggaa aagtcttctg tttaaaacag aggatggcgt gaacatgtgt      540

accctcatgg ccatggacct tggtgaattg tgtgaagaca caatcacgta caagtgtccc      600

cttctcaggc agaatgagcc agaagacata gactgttggt gcaactctac gtccacgtgg      660

gtaacttatg ggacgtgtac caccatggga gaacatagaa gagaaaaaag atcagtggca      720

ctcgttccac atgtgggaat gggactggag acgcgtactg aaacatggat gtcatcagaa      780

ggggcctgga aacatgtcca gagaattgaa acttggatct tgagacatcc aggcttcacc      840

atgatggcag caatcctggc atacaccata ggaacgacac atttccaaag agccctgatt      900

ttcatcttac tgacagctgt cactccttca atgacaatgc gttgcatagg aatgtcaaat      960

agagactttg tggaaggggt ttcaggagga agctgggttg acatagtctt agaacatgga     1020

agctgtgtga cgacgatggc aaaaaacaaa ccaacattgg attttgaact gataaaaaca     1080

gaagccaaac agcctgccac cctaaggaag tactgtatag aggcaaagct aaccaacaca     1140

acaacagaat ctcgctgccc aacacaaggg gaacccagcc taaatgaaga gcaggacaaa     1200

aggttcgtct gcaaacactc catggtagac agaggatggg gaaatggatg tggactattt     1260

ggaaagggag gcattgtgac ctgtgctatg ttcagatgca aaaagaacat ggaaggaaaa     1320

gttgtgcaac cagaaaactt ggaatacacc attgtgataa cacctcactc aggggaagaa     1380

catgcagtcg gaaatgacac aggaaaacat ggcaaggaaa tcaaaataac accacagagt     1440

tccatcacag aagcagaatt gacaggttat ggcactgtca caatggagtg ctctccaaga     1500

acgggcctcg acttcaatga gatggtgttg ctgcagatgg aaaataaggc ttggctggtg     1560

cacaggcaat ggttcctaga cctgccgtta ccatggttgc ccggagcgga cacacaaggg     1620

tcaaattgga tacagaaaga gacattggtc actttcaaaa atccccatgc gaagaaacag     1680

gatgttgttg ttttaggatc ccaagaaggg gccatgcaca cagcacttac aggggccaca     1740

gaaatccaaa tgagctcagg aaacttactc ttcacaggac atctcaagtg caggctgaga     1800

atggacaagc tacagctcaa aggaatgtca tactctatgt gcacaggaaa gtttaaagtt     1860

gtgaaggaaa tagcagaaac acaacatgga acaatagtta tcagagtgca atatgaaggg     1920

gacggctctc catgcaagat cccttttgag ataatggatt tggaaaaaag acatgtctta     1980

ggtcgcctga ttacagtcaa cccaattgtg acagaaaaag atagcccagt caacatagaa     2040

gcagaacctc cattcggaga cagctacatc atcataggag tagagccggg acaactgaag     2100

ctcaactggt ttaagaaagg aagttctatc ggccaaatgt ttgagacaac aatgaggggg     2160

gcgaagagaa tggccatttt aggtgacaca gcctgggatt ttggatcctt gggaggagtg     2220

tttacatcta taggaaaggc tctccaccaa gtctttggag caatctatgg agctgccttc     2280

agtggggttt catggactat gaaaatcctc ataggagtca ttatcacatg gataggaatg     2340

aattcacgca gcacctcact gtctgtgaca ttagtattgg tgggaattgt gacactgtat     2400

ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa caaagaactg     2460

aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag     2520

ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca tgaagagggc     2580

atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca     2640

gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc     2700

aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat     2760

tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt     2820

ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg     2880

gaagttgaag actatggctt tggagtattc accaccaata tatggcttaa gttgaaagaa     2940

aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc     3000

gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag     3060

aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc     3120

aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa     3180

cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagcta     3240

gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat     3300

agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc     3360

cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg     3420

gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga     3480

catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa     3540

atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg     3600

acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc     3660

gccactatga cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc     3720

aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc caaggaattg     3780

atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga gaccattctt     3840

gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa     3900

aagtatcagt tggcagtgac tatcatggct atcttgtgcg tcccaaacgc agtgatatta     3960

caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgctc     4020

ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc     4080

aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca     4140

ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa     4200

aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt gtgctacgtg     4260

ctcactggac gatcggcaga tttggaactg gagagagcag ccgatgtcaa atgggaagac     4320

caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc     4380

atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag aaccggtttg     4440

ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg     4500

tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc cccacccatg     4560

ggaaaggctg aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat     4620

tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca     4680

cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag     4740

aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa     4800

gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca aacgaaacct     4860

ggtcttttca aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga     4920

acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt     4980

gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa     5040

gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc     5100

cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga agctataaaa     5160

cggggtttga gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa     5220

gcccttagag gacttccaat aagataccag accccagcca tcagagctga gcacaccggg     5280

cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt     5340

agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga cccagcaagt     5400

atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc tgggattttt     5460

atgacagcca ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata     5520

gatgaagaaa gagaaatccc tgaacgttcg tggaattccg gtcatgaatg ggtcacggat     5580

tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct     5640

tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag     5700

tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat ttcagaaatg     5760

ggtgccaatt tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata     5820

ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt     5880

gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata     5940

tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg     6000

ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga accagagcgt     6060

gaaaaggtgg atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt     6120

gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa     6180

ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta     6240

gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc     6300

agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt taaggaattt     6360

gcagccggaa gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc     6420

ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag     6480

gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg     6540

cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgga     6600

aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggcaag catcctccta     6660

tggtacgcac aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc     6720

atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc     6780

tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc     6840

ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc     6900

aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc cgtggccaca     6960

acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta     7020

acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca     7080

aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata     7140

actctcacag cagctctttt cttattggta gcacattatg ccatcatagg gcctggcctg     7200

caggcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca     7260

actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa     7320

aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg     7380

actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc cacattgtgg     7440

gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt     7500

agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac     7560

acaagaaggg gaactggaaa catcggcgaa acattaggcg aaaagtggaa gagtagattg     7620

aacgctctcg gtaagtctga attccaaatc tacaagaaat ccgggataca agaagttgat     7680

agaacactcg caaaagaggg aatcaaaaga ggcgaaaccg atcatcacgc cgttagcaga     7740

gggtccgcta aacttagatg gttcgtcgaa cgtaacatgg tgacacccga aggtaaggta     7800

gtcgatctcg gatgtggccg cggagggtgg tcatactatt gtggcggatt gaagaatgta     7860

cgcgaagtga aaggcctaac gaaaggcgga cccggacacg aggaaccaat cccaatgagt     7920

acatacggat ggaatctagt gagactgcaa tccggcgttg acgttttctt catacctccc     7980

gaaaagtgcg atacactgtt atgtgacatc ggcgaatcta gtcccaatcc gacagtcgaa     8040

gccggaagaa cacttagggt gcttaaccta gtcgagaatt ggttgaacaa caatacgcaa     8100

ttttgtataa aggtgcttaa cccatatatg ccaagcgtaa tcgaaaaaat ggaagcactg     8160

caacgtaagt acggaggggc attagtgaga aatcccctat cacgtaacag tacacacgaa     8220

atgtattggg tgtcaaacgc atccggaaac atagtgtcaa gcgtaaacat gataagcaga     8280

atgctaatca atagattcac aatgcgatac aaaaaagcga catacgaacc ggacgttgat     8340

ctcggaagcg gaacacgtaa tatcggaatc gaaagcgaaa ttccgaatct ggacataatc     8400

ggaaagagaa tcgaaaagat taagcaagag cacgaaacca gttggcatta cgatcaggac     8460

catccataca aaacatgggc ataccacggg tcatacgaaa ctaagcaaac cggatccgct     8520

agttcaatgg tgaacggagt ggttagacta ctaacgaaac cttgggacgt agtgccaatg     8580

gtgacacaaa tggcaatgac cgatacaaca ccattcggac agcagcgcgt attcaaagag     8640

aaggtcgata cgagaacaca ggaaccaaaa gagggaacga aaaaactgat gaagattact     8700

gccgaatggt tatggaaaga gttagggaaa aaaaagactc ccagaatgtg tacgagagag     8760

gaattcacac gaaaagtgag atcaaacgca gcactcggag caatattcac agacgaaaac     8820

aaatggaaat ccgcacgcga agccgttgag gacagtagat tttgggagtt agtcgacaaa     8880

gagagaaatc tgcatctcga agggaaatgc gaaacatgcg tttacaatat gatgggtaag     8940

agagagaaaa agttaggcga attcggaaag gctaaggggt caagggcaat ttggtatatg     9000

tggttagggg ctagatttct cgaatttgaa gccctaggat tccttaacga agaccattgg     9060

tttagcagag agaatagtct atccggagtc gaaggcgaag ggttacacaa actagggtat     9120

atactgagag acgtctcgaa aaaagaggga ggcgcaatgt acgccgacga tacagccgga     9180

tgggacacta ggattacact cgaagatctg aaaaacgaag agatggttac gaaccatatg     9240

gaaggcgaac acaaaaaact agccgaagcc atattcaaac taacatacca aaacaaagtg     9300

gttagggtgc aacgaccaac acctagagga accgttatgg acataatatc gagaagggac     9360

caacgaggat ccggacaagt cggaacatac ggattgaaca cttttacgaa tatggaagcc     9420

caactgatta ggcaaatgga aggcgaagga gtgttcaaat caatccaaca cctaacgatt     9480

accgaagaga ttgccgttca gaattggtta gctagagtgg gacgcgaacg gttaagcaga     9540

atggcaatat ccggagacga ttgcgtagtg aaaccattgg acgatagatt cgcaagcgca     9600

ctaaccgcat tgaacgatat gggtaagatt agaaaggaca tacagcaatg ggaaccatca     9660

agggggtgga acgattggac acaagtgcca ttctgttcac atcattttca cgagttgatt     9720

atgaaagacg gaagggtgtt agtggtgcca tgtagaaacc aagacgaatt gatcggaagg     9780

gcacgtatat cgcaaggggc cggatggtca cttagggaaa cagcatgttt agggaaatca     9840

tacgctcaaa tgtggtcact gatgtatttc catagaaggg accttagatt ggcagcaaac     9900

gcaatttgtt ccgccgtacc atcacattgg gtgccaacat cacgtacgac atggtcaata     9960

cacgctaagc acgaatggat gacaaccgaa gacatgctaa ccgtttggaa tagggtttgg    10020

atacaagaga atccatggat ggaagacaaa acacccgtcg aaagttggga ggaaattcca    10080

tacctcggta agagagagga ccaatggtgt ggatcgctaa tcgggttgac tagcagagca    10140

acatgggcaa aaaacataca agccgcaatc aatcaggtta ggtcactaat cggaaacgaa    10200

gagtatactg actatatgcc atcaatgaaa agattcagac gcgaagagga ggaagccgga    10260

gtgttgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc    10320

catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca    10380

ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg    10440

tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc    10500

ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga    10560

agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag    10620

catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca    10680

gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct                      10723


