                         SEQUENCE LISTING

<110>  HudsonAlpha Institute for Biotechnology
 
<120>  BIOMARKERS FOR TRIPLE-NEGATIVE BREAST CANCER

<130>  00H670-301084

<150>  us62/045,204
<151>  2014-09-03

<150>  us 62/069,706
<151>  2014-10-28

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  1131
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Ile Glu His Ile Gly Pro Asp Glu Val 
        115                 120                 125             


Ile Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln 
    130                 135                 140                 


Lys Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys 
145                 150                 155                 160 


Pro Ala Glu Pro Pro Thr Val Val Thr Gly Ser Leu Leu Val Gly Pro 
                165                 170                 175     


Val Ser Asp Cys Ser Thr Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe 
            180                 185                 190         


Asn Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Thr Asp Gln 
        195                 200                 205             


Ile Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro 
    210                 215                 220                 


Glu Gly Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly 
225                 230                 235                 240 


Leu Trp Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile 
                245                 250                 255     


Tyr His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly 
            260                 265                 270         


Phe Thr Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr 
        275                 280                 285             


Ser Pro Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro 
    290                 295                 300                 


Ala Leu Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr 
305                 310                 315                 320 


Gln Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro 
                325                 330                 335     


Glu Pro Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Thr Tyr Gly Ala 
            340                 345                 350         


Glu Pro Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln 
        355                 360                 365             


Ala Arg Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala 
    370                 375                 380                 


Thr Pro Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu 
385                 390                 395                 400 


Val Leu Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Thr Arg Val 
                405                 410                 415     


Ile Ala Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly 
            420                 425                 430         


Ala Val Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe 
        435                 440                 445             


Val Phe Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr 
    450                 455                 460                 


Gly Leu Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala 
465                 470                 475                 480 


Ala Asp Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu 
                485                 490                 495     


Leu Ile Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu 
            500                 505                 510         


His Ser Thr Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly 
        515                 520                 525             


Leu Leu Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Thr Leu 
    530                 535                 540                 


Leu Leu Thr Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys 
545                 550                 555                 560 


Ala Asp Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln 
                565                 570                 575     


Ala Tyr Val Met Arg Tyr Phe Glu Ser Ser Gly Met Thr Glu His Gln 
            580                 585                 590         


Asp Arg Ala Leu Thr Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His 
        595                 600                 605             


Ser His Ser Pro Thr Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala 
    610                 615                 620                 


Leu Leu Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Thr Leu Thr Gly 
625                 630                 635                 640 


Leu Tyr Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly 
                645                 650                 655     


Ala Leu Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His 
            660                 665                 670         


Gln Ser Thr Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Thr 
        675                 680                 685             


Trp Ala Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu 
    690                 695                 700                 


Ser Glu Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala 
705                 710                 715                 720 


Leu Trp Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln 
                725                 730                 735     


Tyr Leu Ala Leu Thr Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu 
            740                 745                 750         


Glu Gly Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala 
        755                 760                 765             


Arg Cys Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp 
    770                 775                 780                 


Arg Lys Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly 
785                 790                 795                 800 


Thr Leu Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu 
                805                 810                 815     


Ala Glu Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly 
            820                 825                 830         


Arg Leu Ser Phe Leu Gly Thr Arg Leu Thr Pro Pro Asp Ala His Val 
        835                 840                 845             


Leu Gly Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu 
    850                 855                 860                 


Arg Ser Thr Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu 
865                 870                 875                 880 


Ser Cys Val Thr Arg Phe Arg Ala Ala Leu Ser Asp Thr Val Ala Leu 
                885                 890                 895     


Trp Glu Ser Leu Gln Gln His Gly Glu Thr Lys Leu Leu Gln Ala Ala 
            900                 905                 910         


Glu Glu Lys Phe Thr Ile Glu Pro Phe Lys Ala Lys Ser Leu Lys Asp 
        915                 920                 925             


Val Glu Asp Leu Gly Lys Leu Val Gln Thr Gln Arg Thr Arg Ser Ser 
    930                 935                 940                 


Ser Glu Asp Thr Ala Gly Glu Leu Pro Ala Val Arg Asp Leu Lys Lys 
945                 950                 955                 960 


Leu Glu Phe Ala Leu Gly Pro Val Ser Gly Pro Gln Ala Phe Pro Lys 
                965                 970                 975     


Leu Val Arg Ile Leu Thr Ala Phe Ser Ser Leu Gln His Leu Asp Leu 
            980                 985                 990         


Asp Ala Leu Ser Glu Asn Lys Ile  Gly Asp Glu Gly Val  Ser Gln Leu 
        995                 1000                 1005             


Ser Ala  Thr Phe Pro Gln Leu  Lys Ser Leu Glu Thr  Leu Asn Leu 
    1010                 1015                 1020             


Ser Gln  Asn Asn Ile Thr Asp  Leu Gly Ala Tyr Lys  Leu Ala Glu 
    1025                 1030                 1035             


Ala Leu  Pro Ser Leu Ala Ala  Ser Leu Leu Arg Leu  Ser Leu Tyr 
    1040                 1045                 1050             


Asn Asn  Cys Ile Cys Asp Val  Gly Ala Glu Ser Leu  Ala Arg Val 
    1055                 1060                 1065             


Leu Pro  Asp Met Val Ser Leu  Arg Val Met Asp Val  Gln Tyr Asn 
    1070                 1075                 1080             


Lys Phe  Thr Ala Ala Gly Ala  Gln Gln Leu Ala Ala  Ser Leu Arg 
    1085                 1090                 1095             


Arg Cys  Pro His Val Glu Thr  Leu Ala Met Trp Thr  Pro Thr Ile 
    1100                 1105                 1110             


Pro Phe  Ser Val Gln Glu His  Leu Gln Gln Gln Asp  Ser Arg Ile 
    1115                 1120                 1125             


Ser Leu  Arg 
    1130     


<210>  2
<211>  1130
<212>  PRT
<213>  homo sapiens

<400>  2

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Ala Glu Pro Pro Thr Val Val Thr Gly Ser Leu Leu Val Gly Pro Val 
                165                 170                 175     


Ser Asp Cys Ser Thr Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe Asn 
            180                 185                 190         


Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Thr Asp Gln Ile 
        195                 200                 205             


Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu 
    210                 215                 220                 


Gly Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly Leu 
225                 230                 235                 240 


Trp Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile Tyr 
                245                 250                 255     


His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe 
            260                 265                 270         


Thr Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr Ser 
        275                 280                 285             


Pro Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro Ala 
    290                 295                 300                 


Leu Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr Gln 
305                 310                 315                 320 


Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Glu 
                325                 330                 335     


Pro Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Thr Tyr Gly Ala Glu 
            340                 345                 350         


Pro Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln Ala 
        355                 360                 365             


Arg Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala Thr 
    370                 375                 380                 


Pro Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu Val 
385                 390                 395                 400 


Leu Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Thr Arg Val Ile 
                405                 410                 415     


Ala Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly Ala 
            420                 425                 430         


Val Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe Val 
        435                 440                 445             


Phe Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr Gly 
    450                 455                 460                 


Leu Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala Ala 
465                 470                 475                 480 


Asp Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu Leu 
                485                 490                 495     


Ile Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu His 
            500                 505                 510         


Ser Thr Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly Leu 
        515                 520                 525             


Leu Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Thr Leu Leu 
    530                 535                 540                 


Leu Thr Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys Ala 
545                 550                 555                 560 


Asp Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln Ala 
                565                 570                 575     


Tyr Val Met Arg Tyr Phe Glu Ser Ser Gly Met Thr Glu His Gln Asp 
            580                 585                 590         


Arg Ala Leu Thr Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His Ser 
        595                 600                 605             


His Ser Pro Thr Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala Leu 
    610                 615                 620                 


Leu Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Thr Leu Thr Gly Leu 
625                 630                 635                 640 


Tyr Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly Ala 
                645                 650                 655     


Leu Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His Gln 
            660                 665                 670         


Ser Thr Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Thr Trp 
        675                 680                 685             


Ala Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu Ser 
    690                 695                 700                 


Glu Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala Leu 
705                 710                 715                 720 


Trp Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln Tyr 
                725                 730                 735     


Leu Ala Leu Thr Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu Glu 
            740                 745                 750         


Gly Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala Arg 
        755                 760                 765             


Cys Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp Arg 
    770                 775                 780                 


Lys Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly Thr 
785                 790                 795                 800 


Leu Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu Ala 
                805                 810                 815     


Glu Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly Arg 
            820                 825                 830         


Leu Ser Phe Leu Gly Thr Arg Leu Thr Pro Pro Asp Ala His Val Leu 
        835                 840                 845             


Gly Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu Arg 
    850                 855                 860                 


Ser Thr Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu Ser 
865                 870                 875                 880 


Cys Val Thr Arg Phe Arg Ala Ala Leu Ser Asp Thr Val Ala Leu Trp 
                885                 890                 895     


Glu Ser Leu Gln Gln His Gly Glu Thr Lys Leu Leu Gln Ala Ala Glu 
            900                 905                 910         


Glu Lys Phe Thr Ile Glu Pro Phe Lys Ala Lys Ser Leu Lys Asp Val 
        915                 920                 925             


Glu Asp Leu Gly Lys Leu Val Gln Thr Gln Arg Thr Arg Ser Ser Ser 
    930                 935                 940                 


Glu Asp Thr Ala Gly Glu Leu Pro Ala Val Arg Asp Leu Lys Lys Leu 
945                 950                 955                 960 


Glu Phe Ala Leu Gly Pro Val Ser Gly Pro Gln Ala Phe Pro Lys Leu 
                965                 970                 975     


Val Arg Ile Leu Thr Ala Phe Ser Ser Leu Gln His Leu Asp Leu Asp 
            980                 985                 990         


Ala Leu Ser Glu Asn Lys Ile Gly  Asp Glu Gly Val Ser  Gln Leu Ser 
        995                 1000                 1005             


Ala Thr  Phe Pro Gln Leu Lys  Ser Leu Glu Thr Leu  Asn Leu Ser 
    1010                 1015                 1020             


Gln Asn  Asn Ile Thr Asp Leu  Gly Ala Tyr Lys Leu  Ala Glu Ala 
    1025                 1030                 1035             


Leu Pro  Ser Leu Ala Ala Ser  Leu Leu Arg Leu Ser  Leu Tyr Asn 
    1040                 1045                 1050             


Asn Cys  Ile Cys Asp Val Gly  Ala Glu Ser Leu Ala  Arg Val Leu 
    1055                 1060                 1065             


Pro Asp  Met Val Ser Leu Arg  Val Met Asp Val Gln  Tyr Asn Lys 
    1070                 1075                 1080             


Phe Thr  Ala Ala Gly Ala Gln  Gln Leu Ala Ala Ser  Leu Arg Arg 
    1085                 1090                 1095             


Cys Pro  His Val Glu Thr Leu  Ala Met Trp Thr Pro  Thr Ile Pro 
    1100                 1105                 1110             


Phe Ser  Val Gln Glu His Leu  Gln Gln Gln Asp Ser  Arg Ile Ser 
    1115                 1120                 1125             


Leu Arg  
    1130 


<210>  3
<211>  546
<212>  PRT
<213>  homo sapiens

<400>  3

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Val Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu Gly 
                165                 170                 175     


Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly Leu Trp 
            180                 185                 190         


Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile Tyr His 
        195                 200                 205             


Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe Thr 
    210                 215                 220                 


Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr Ser Pro 
225                 230                 235                 240 


Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro Ala Leu 
                245                 250                 255     


Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr Gln Cys 
            260                 265                 270         


Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Gly Leu 
        275                 280                 285             


Ala Trp Ser Pro Cys Leu Gly Leu Arg Pro Ser Leu His Arg Ala Ala 
    290                 295                 300                 


Leu Ser Asp Thr Val Ala Leu Trp Glu Ser Leu Gln Gln His Gly Glu 
305                 310                 315                 320 


Thr Lys Leu Leu Gln Ala Ala Glu Glu Lys Phe Thr Ile Glu Pro Phe 
                325                 330                 335     


Lys Ala Lys Ser Leu Lys Asp Val Glu Asp Leu Gly Lys Leu Val Gln 
            340                 345                 350         


Thr Gln Arg Thr Arg Ser Ser Ser Glu Asp Thr Ala Gly Glu Leu Pro 
        355                 360                 365             


Ala Val Arg Asp Leu Lys Lys Leu Glu Phe Ala Leu Gly Pro Val Ser 
    370                 375                 380                 


Gly Pro Gln Ala Phe Pro Lys Leu Val Arg Ile Leu Thr Ala Phe Ser 
385                 390                 395                 400 


Ser Leu Gln His Leu Asp Leu Asp Ala Leu Ser Glu Asn Lys Ile Gly 
                405                 410                 415     


Asp Glu Gly Val Ser Gln Leu Ser Ala Thr Phe Pro Gln Leu Lys Ser 
            420                 425                 430         


Leu Glu Thr Leu Asn Leu Ser Gln Asn Asn Ile Thr Asp Leu Gly Ala 
        435                 440                 445             


Tyr Lys Leu Ala Glu Ala Leu Pro Ser Leu Ala Ala Ser Leu Leu Arg 
    450                 455                 460                 


Leu Ser Leu Tyr Asn Asn Cys Ile Cys Asp Val Gly Ala Glu Ser Leu 
465                 470                 475                 480 


Ala Arg Val Leu Pro Asp Met Val Ser Leu Arg Val Met Asp Val Gln 
                485                 490                 495     


Tyr Asn Lys Phe Thr Ala Ala Gly Ala Gln Gln Leu Ala Ala Ser Leu 
            500                 505                 510         


Arg Arg Cys Pro His Val Glu Thr Leu Ala Met Trp Thr Pro Thr Ile 
        515                 520                 525             


Pro Phe Ser Val Gln Glu His Leu Gln Gln Gln Asp Ser Arg Ile Ser 
    530                 535                 540                 


Leu Arg 
545     


<210>  4
<211>  296
<212>  PRT
<213>  homo sapiens

<400>  4

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                 215                 220                 


Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                 230                 235                 240 


Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                 250                 255     


Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
            260                 265                 270         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        275                 280                 285             


Gln Asp Leu Gly Pro Val Pro Met 
    290                 295     


<210>  5
<211>  232
<212>  PRT
<213>  homo sapiens

<400>  5

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
    210                 215                 220                 


Gln Asp Leu Gly Pro Val Pro Met 
225                 230         


<210>  6
<211>  160
<212>  PRT
<213>  homo sapiens

<400>  6

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Ser His Trp Asn Trp Arg Thr Arg Leu Leu Gly Trp Val 
145                 150                 155                 160 


<210>  7
<211>  260
<212>  PRT
<213>  homo sapiens

<400>  7

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210>  8
<211>  258
<212>  PRT
<213>  homo sapiens

<400>  8

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  9
<211>  805
<212>  DNA
<213>  homo sapiens

<400>  9
atgatgatcc tgcaggtttc agcgggcccc cggacagtgg ctctgacagc attactgatg       60

gtgcggctca tatctgtggt ccagagcagg accactccag agaattccgt ctaccaggaa      120

cggcaggaat gctatgcgtt caatgggact cagcgcgttg tggacgggct catctacaac      180

cgggaggaat acgtgcattt tgacagcgca gtgggggagt tcctagcagt gatggagctg      240

gggcggccca taggcgagta cttcaatagc cagaaggact ttatggaacg gaagcgagcc      300

gaggtggaca aggtgtgcag acacaagtac gagctgatgg agccactcat ccggcagcgc      360

cgagtccagc ctagggtgaa catctcccct ccaagaagga gccccagcag caccacgacc      420

tgcttgtcta ccacgtgaca gatttctacc cagacagcat tcaagtccga tgcttcctga      480

atggacagga ggaaacagct ggggtcgtgt ccaccaacct gatccgtaat ggagactgga      540

ccttccagat cctggagatg ctggaaatga ccccccagca gggaaacatc tacacctgcc      600

aagtggagca ccccagcctg gacagtcctg tcaccgtgga gtggaaggca cagtctgatt      660

ctgtgcagag caagatgctg acaggagcta ggggcttcat gctggggctc atcatctgtg      720

gagtggacat cttcacgcac agaaggagga agaaagttca acaaggacct gcataaacag      780

gcaatattcc tgctttgatt tcctt                                            805


<210>  10
<211>  255
<212>  PRT
<213>  homo sapiens

<400>  10

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  11
<211>  266
<212>  PRT
<213>  homo sapiens

<400>  11

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  12
<211>  266
<212>  PRT
<213>  homo sapiens

<400>  12

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  13
<211>  266
<212>  PRT
<213>  homo sapiens

<400>  13

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Tyr Met Ala Lys Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Asp Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Arg Thr Gln Thr Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Lys Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu His Pro Thr Gly Leu Val Ser 
            260                 265     


<210>  14
<211>  1235
<212>  DNA
<213>  homo sapiens

<400>  14
gaatacagaa tgtgggcaaa ctcgcttctg tgccggccgc cagaaggttt gctgagggca       60

atcactccct ggtgccgggc tccttgaggt tatgcactgg gacatctaga gcctattgtt      120

tgaggaatgc agtcttgcaa gcctgctctg gatcaagcca cagactgaaa cacccccgaa      180

gagcaagcac gtttcttgga gcaggctaag tgtgagtgtc atatcttcaa tgggatgaag      240

cgggtgcagt acctgaacag atacatccat aaacgggagg agaacctgcg cttcgacagc      300

aacgtggagg agttccaggc agttacggaa ctggggcggc ctgtcgcaga gaactggaac      360

agccagaagg gcatcccgga ggagaagcgg gacaagatgg acgactactg cagatacaat      420

tacggggttt tttgagagct tcacagtgca gccgcgagtc catcctaagg tgactgtgta      480

tcctgcaaag acccagcccc tgcatcaccg caaccccctg gtcggctctg tgagtggttt      540

ctatccaggc agcattaaag tcaggtggtt ccagaatggt caggaagaga aggctgcggt      600

ggtctccata ggcctgatcc agaatggaga ttggaccttc cagaccctgg tgatgctgga      660

aacagttcct cggagtggag aggtttacac ctgccaagtg gagcatccaa gcgtgacgag      720

ccctctcaca gtggaatgga gtacacggac tgaatctgca cagagcaaga tgctgagtgg      780

agtcgggggc tttgtgctgg gcctgctctt ccttgggaca gggctgttca tctacttcag      840

gaatcagaaa ggacactctg gacttcagcc aacaggactc ctgcgctgga ctcctgagct      900

gaagtgcaca tgaccacatt caaggaagaa ccttctgcca cagctttgca ggatgaaaag      960

ctttcccact tggctcttat tcttccacaa gagctctctc aggaccaggt tgttactcgt     1020

tcagcaactc tgcagaaaat gccctccctt gtggcttcct cagctcctgt tcttggcctg     1080

aaaccccaca gccttgatgg cagcgcctcg tcttcaactt ttgtgcttcc ttttacctaa     1140

attttcctgc ctcccctggg tctgtattcc ccttgtgcca caaacacatt gcattattca     1200

atgtttctca aacatggagt taaaaattat ctggt                                1235


<210>  15
<211>  335
<212>  PRT
<213>  homo sapiens

<400>  15

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Glu Lys 
            20                  25                  30          


Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys Thr Tyr Ser Thr 
        35                  40                  45              


Glu Glu Tyr His His Arg Leu Gln Thr Phe Ala Ser Asn Trp Arg Lys 
    50                  55                  60                  


Ile Asn Ala His Asn Asn Gly Asn His Thr Phe Lys Met Ala Leu Asn 
65                  70                  75                  80  


Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His Lys Tyr Leu Trp 
                85                  90                  95      


Ser Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn Tyr Leu Arg Gly 
            100                 105                 110         


Thr Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys Lys Gly Asn Phe 
        115                 120                 125             


Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Thr Phe 
    130                 135                 140                 


Ser Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile Ala Thr Gly Lys 
145                 150                 155                 160 


Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys Ala Gln Asp Phe 
                165                 170                 175     


Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr 
            180                 185                 190         


Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr Tyr Pro Tyr Gln 
        195                 200                 205             


Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe 
    210                 215                 220                 


Val Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu Glu Ala Met Val 
225                 230                 235                 240 


Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala Phe Glu Val Thr 
                245                 250                 255     


Gln Asp Phe Met Met Tyr Arg Thr Gly Ile Tyr Ser Ser Thr Ser Cys 
            260                 265                 270         


His Lys Thr Pro Asp Lys Val Asn His Ala Val Leu Ala Val Gly Tyr 
        275                 280                 285             


Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn 
305                 310                 315                 320 


Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile Pro Leu Val 
                325                 330                 335 


<210>  16
<211>  1441
<212>  PRT
<213>  homo sapiens

<400>  16

Met Ser Gly Leu Gly Asp Ser Ser Ser Asp Pro Ala Asn Pro Asp Ser 
1               5                   10                  15      


His Lys Arg Lys Gly Ser Pro Cys Asp Thr Leu Ala Ser Ser Thr Glu 
            20                  25                  30          


Lys Arg Arg Arg Glu Gln Glu Asn Lys Tyr Leu Glu Glu Leu Ala Glu 
        35                  40                  45              


Leu Leu Ser Ala Asn Ile Ser Asp Ile Asp Ser Leu Ser Val Lys Pro 
    50                  55                  60                  


Asp Lys Cys Lys Ile Leu Lys Lys Thr Val Asp Gln Ile Gln Leu Met 
65                  70                  75                  80  


Lys Arg Met Glu Gln Glu Lys Ser Thr Thr Asp Asp Asp Val Gln Lys 
                85                  90                  95      


Ser Asp Ile Ser Ser Ser Ser Gln Gly Val Ile Glu Lys Glu Ser Leu 
            100                 105                 110         


Gly Pro Leu Leu Leu Glu Ala Leu Asp Gly Phe Phe Phe Val Val Asn 
        115                 120                 125             


Cys Glu Gly Arg Ile Val Phe Val Ser Glu Asn Val Thr Ser Tyr Leu 
    130                 135                 140                 


Gly Tyr Asn Gln Glu Glu Leu Met Asn Thr Ser Val Tyr Ser Ile Leu 
145                 150                 155                 160 


His Val Gly Asp His Ala Glu Phe Val Lys Asn Leu Leu Pro Lys Ser 
                165                 170                 175     


Leu Val Asn Gly Val Pro Trp Pro Gln Glu Ala Thr Arg Arg Asn Ser 
            180                 185                 190         


His Thr Phe Asn Cys Arg Met Leu Ile His Pro Pro Asp Glu Pro Gly 
        195                 200                 205             


Thr Glu Asn Gln Glu Ala Cys Gln Arg Tyr Glu Val Met Gln Cys Phe 
    210                 215                 220                 


Thr Val Ser Gln Pro Lys Ser Ile Gln Glu Asp Gly Glu Asp Phe Gln 
225                 230                 235                 240 


Ser Cys Leu Ile Cys Ile Ala Arg Arg Leu Pro Arg Pro Pro Ala Ile 
                245                 250                 255     


Thr Gly Val Glu Ser Phe Met Thr Lys Gln Asp Thr Thr Gly Lys Ile 
            260                 265                 270         


Ile Ser Ile Asp Thr Ser Ser Leu Arg Ala Ala Gly Arg Thr Gly Trp 
        275                 280                 285             


Glu Asp Leu Val Arg Lys Cys Ile Tyr Ala Phe Phe Gln Pro Gln Gly 
    290                 295                 300                 


Arg Glu Pro Ser Tyr Ala Arg Gln Leu Phe Gln Glu Val Met Thr Arg 
305                 310                 315                 320 


Gly Thr Ala Ser Ser Pro Ser Tyr Arg Phe Ile Leu Asn Asp Gly Thr 
                325                 330                 335     


Met Leu Ser Ala His Thr Lys Cys Lys Leu Cys Tyr Pro Gln Ser Pro 
            340                 345                 350         


Asp Met Gln Pro Phe Ile Met Gly Ile His Ile Ile Asp Arg Glu His 
        355                 360                 365             


Ser Gly Leu Ser Pro Gln Asp Asp Thr Asn Ser Gly Met Ser Ile Pro 
    370                 375                 380                 


Arg Val Asn Pro Ser Val Asn Pro Ser Ile Ser Pro Ala His Gly Val 
385                 390                 395                 400 


Ala Arg Ser Ser Thr Leu Pro Pro Ser Asn Ser Asn Met Val Ser Thr 
                405                 410                 415     


Arg Ile Asn Arg Gln Gln Ser Ser Asp Leu His Ser Ser Ser His Ser 
            420                 425                 430         


Asn Ser Ser Asn Ser Gln Gly Ser Phe Gly Cys Ser Pro Gly Ser Gln 
        435                 440                 445             


Ile Val Ala Asn Val Ala Leu Asn Gln Gly Gln Ala Ser Ser Gln Ser 
    450                 455                 460                 


Ser Asn Pro Ser Leu Asn Leu Asn Asn Ser Pro Met Glu Gly Thr Gly 
465                 470                 475                 480 


Ile Ser Leu Ala Gln Phe Met Ser Pro Arg Arg Gln Val Thr Ser Gly 
                485                 490                 495     


Leu Ala Thr Arg Pro Arg Met Pro Asn Asn Ser Phe Pro Pro Asn Ile 
            500                 505                 510         


Ser Thr Leu Ser Ser Pro Val Gly Met Thr Ser Ser Ala Cys Asn Asn 
        515                 520                 525             


Asn Asn Arg Ser Tyr Ser Asn Ile Pro Val Thr Ser Leu Gln Gly Met 
    530                 535                 540                 


Asn Glu Gly Pro Asn Asn Ser Val Gly Phe Ser Ala Ser Ser Pro Val 
545                 550                 555                 560 


Leu Arg Gln Met Ser Ser Gln Asn Ser Pro Ser Arg Leu Asn Ile Gln 
                565                 570                 575     


Pro Ala Lys Ala Glu Ser Lys Asp Asn Lys Glu Ile Ala Ser Ile Leu 
            580                 585                 590         


Asn Glu Met Ile Gln Ser Asp Asn Ser Ser Ser Asp Gly Lys Pro Leu 
        595                 600                 605             


Asp Ser Gly Leu Leu His Asn Asn Asp Arg Leu Ser Asp Gly Asp Ser 
    610                 615                 620                 


Lys Tyr Ser Gln Thr Ser His Lys Leu Val Gln Leu Leu Thr Thr Thr 
625                 630                 635                 640 


Ala Glu Gln Gln Leu Arg His Ala Asp Ile Asp Thr Ser Cys Lys Asp 
                645                 650                 655     


Val Leu Ser Cys Thr Gly Thr Ser Asn Ser Ala Ser Ala Asn Ser Ser 
            660                 665                 670         


Gly Gly Ser Cys Pro Ser Ser His Ser Ser Leu Thr Glu Arg His Lys 
        675                 680                 685             


Ile Leu His Arg Leu Leu Gln Glu Gly Ser Pro Ser Asp Ile Thr Thr 
    690                 695                 700                 


Leu Ser Val Glu Pro Asp Lys Lys Asp Ser Ala Ser Thr Ser Val Ser 
705                 710                 715                 720 


Val Thr Gly Gln Val Gln Gly Asn Ser Ser Ile Lys Leu Glu Leu Asp 
                725                 730                 735     


Ala Ser Lys Lys Lys Glu Ser Lys Asp His Gln Leu Leu Arg Tyr Leu 
            740                 745                 750         


Leu Asp Lys Asp Glu Lys Asp Leu Arg Ser Thr Pro Asn Leu Ser Leu 
        755                 760                 765             


Asp Asp Val Lys Val Lys Val Glu Lys Lys Glu Gln Met Asp Pro Cys 
    770                 775                 780                 


Asn Thr Asn Pro Thr Pro Met Thr Lys Pro Thr Pro Glu Glu Ile Lys 
785                 790                 795                 800 


Leu Glu Ala Gln Ser Gln Phe Thr Ala Asp Leu Asp Gln Phe Asp Gln 
                805                 810                 815     


Leu Leu Pro Thr Leu Glu Lys Ala Ala Gln Leu Pro Gly Leu Cys Glu 
            820                 825                 830         


Thr Asp Arg Met Asp Gly Ala Val Thr Ser Val Thr Ile Lys Ser Glu 
        835                 840                 845             


Ile Leu Pro Ala Ser Leu Gln Ser Ala Thr Ala Arg Pro Thr Ser Arg 
    850                 855                 860                 


Leu Asn Arg Leu Pro Glu Leu Glu Leu Glu Ala Ile Asp Asn Gln Phe 
865                 870                 875                 880 


Gly Gln Pro Gly Thr Gly Asp Gln Ile Pro Trp Thr Asn Asn Thr Val 
                885                 890                 895     


Thr Ala Ile Asn Gln Ser Lys Ser Glu Asp Gln Cys Ile Ser Ser Gln 
            900                 905                 910         


Leu Asp Glu Leu Leu Cys Pro Pro Thr Thr Val Glu Gly Arg Asn Asp 
        915                 920                 925             


Glu Lys Ala Leu Leu Glu Gln Leu Val Ser Phe Leu Ser Gly Lys Asp 
    930                 935                 940                 


Glu Thr Glu Leu Ala Glu Leu Asp Arg Ala Leu Gly Ile Asp Lys Leu 
945                 950                 955                 960 


Val Gln Gly Gly Gly Leu Asp Val Leu Ser Glu Arg Phe Pro Pro Gln 
                965                 970                 975     


Gln Ala Thr Pro Pro Leu Ile Met Glu Glu Arg Pro Asn Leu Tyr Ser 
            980                 985                 990         


Gln Pro Tyr Ser Ser Pro Ser Pro  Thr Ala Asn Leu Pro  Ser Pro Phe 
        995                 1000                 1005             


Gln Gly  Met Val Arg Gln Lys  Pro Ser Leu Gly Thr  Met Pro Val 
    1010                 1015                 1020             


Gln Val  Thr Pro Pro Arg Gly  Ala Phe Ser Pro Gly  Met Gly Met 
    1025                 1030                 1035             


Gln Pro  Arg Gln Thr Leu Asn  Arg Pro Pro Ala Ala  Pro Asn Gln 
    1040                 1045                 1050             


Leu Arg  Leu Gln Leu Gln Gln  Arg Leu Gln Gly Gln  Gln Gln Leu 
    1055                 1060                 1065             


Ile His  Gln Asn Arg Gln Ala  Ile Leu Asn Gln Phe  Ala Ala Thr 
    1070                 1075                 1080             


Ala Pro  Val Gly Ile Asn Met  Arg Ser Gly Met Gln  Gln Gln Ile 
    1085                 1090                 1095             


Thr Pro  Gln Pro Pro Leu Asn  Ala Gln Met Leu Ala  Gln Arg Gln 
    1100                 1105                 1110             


Arg Glu  Leu Tyr Ser Gln Gln  His Arg Gln Arg Gln  Leu Ile Gln 
    1115                 1120                 1125             


Gln Gln  Arg Ala Met Leu Met  Arg Gln Gln Ser Phe  Gly Asn Asn 
    1130                 1135                 1140             


Leu Pro  Pro Ser Ser Gly Leu  Pro Val Gln Met Gly  Asn Pro Arg 
    1145                 1150                 1155             


Leu Pro  Gln Gly Ala Pro Gln  Gln Phe Pro Tyr Pro  Pro Asn Tyr 
    1160                 1165                 1170             


Gly Thr  Asn Pro Gly Thr Pro  Pro Ala Ser Thr Ser  Pro Phe Ser 
    1175                 1180                 1185             


Gln Leu  Ala Ala Asn Pro Glu  Ala Ser Leu Ala Asn  Arg Asn Ser 
    1190                 1195                 1200             


Met Val  Ser Arg Gly Met Thr  Gly Asn Ile Gly Gly  Gln Phe Gly 
    1205                 1210                 1215             


Thr Gly  Ile Asn Pro Gln Met  Gln Gln Asn Val Phe  Gln Tyr Pro 
    1220                 1225                 1230             


Gly Ala  Gly Met Val Pro Gln  Gly Glu Ala Asn Phe  Ala Pro Ser 
    1235                 1240                 1245             


Leu Ser  Pro Gly Ser Ser Met  Val Pro Met Pro Ile  Pro Pro Pro 
    1250                 1255                 1260             


Gln Ser  Ser Leu Leu Gln Gln  Thr Pro Pro Ala Ser  Gly Tyr Gln 
    1265                 1270                 1275             


Ser Pro  Asp Met Lys Ala Trp  Gln Gln Gly Ala Ile  Gly Asn Asn 
    1280                 1285                 1290             


Asn Val  Phe Ser Gln Ala Val  Gln Asn Gln Pro Thr  Pro Ala Gln 
    1295                 1300                 1305             


Pro Gly  Val Tyr Asn Asn Met  Ser Ile Thr Val Ser  Met Ala Gly 
    1310                 1315                 1320             


Gly Asn  Thr Asn Val Gln Asn  Met Asn Pro Met Met  Ala Gln Met 
    1325                 1330                 1335             


Gln Met  Ser Ser Leu Gln Met  Pro Gly Met Asn Thr  Val Cys Pro 
    1340                 1345                 1350             


Glu Gln  Ile Asn Asp Pro Ala  Leu Arg His Thr Gly  Leu Tyr Cys 
    1355                 1360                 1365             


Asn Gln  Leu Ser Ser Thr Asp  Leu Leu Lys Thr Glu  Ala Asp Gly 
    1370                 1375                 1380             


Thr Gln  Gln Val Gln Gln Val  Gln Val Phe Ala Asp  Val Gln Cys 
    1385                 1390                 1395             


Thr Val  Asn Leu Val Gly Gly  Asp Pro Tyr Leu Asn  Gln Pro Gly 
    1400                 1405                 1410             


Pro Leu  Gly Thr Gln Lys Pro  Thr Ser Gly Pro Gln  Thr Pro Gln 
    1415                 1420                 1425             


Ala Gln  Gln Lys Ser Leu Leu  Gln Gln Leu Leu Thr  Glu 
    1430                 1435                 1440     


<210>  17
<211>  1399
<212>  PRT
<213>  homo sapiens

<400>  17

Met Ser Gly Leu Gly Asp Ser Ser Ser Asp Pro Ala Asn Pro Asp Ser 
1               5                   10                  15      


His Lys Arg Lys Gly Ser Pro Cys Asp Thr Leu Ala Ser Ser Thr Glu 
            20                  25                  30          


Lys Arg Arg Arg Glu Gln Glu Asn Lys Tyr Leu Glu Glu Leu Ala Glu 
        35                  40                  45              


Leu Leu Ser Ala Asn Ile Ser Asp Ile Asp Ser Leu Ser Val Lys Pro 
    50                  55                  60                  


Asp Lys Cys Lys Ile Leu Lys Lys Thr Val Asp Gln Ile Gln Leu Met 
65                  70                  75                  80  


Lys Arg Met Glu Gln Glu Lys Ser Thr Thr Asp Asp Asp Val Gln Lys 
                85                  90                  95      


Ser Asp Ile Ser Ser Ser Ser Gln Gly Val Ile Glu Lys Glu Ser Leu 
            100                 105                 110         


Gly Pro Leu Leu Leu Glu Ala Leu Asp Gly Phe Phe Phe Val Val Asn 
        115                 120                 125             


Cys Glu Gly Arg Ile Val Phe Val Ser Glu Asn Val Thr Ser Tyr Leu 
    130                 135                 140                 


Gly Tyr Asn Gln Glu Glu Leu Met Asn Thr Ser Val Tyr Ser Ile Leu 
145                 150                 155                 160 


His Val Gly Asp His Ala Glu Phe Val Lys Asn Leu Leu Pro Lys Ser 
                165                 170                 175     


Leu Val Asn Gly Val Pro Trp Pro Gln Glu Ala Thr Arg Arg Asn Ser 
            180                 185                 190         


His Thr Phe Asn Cys Arg Met Leu Ile His Pro Pro Asp Glu Pro Gly 
        195                 200                 205             


Thr Glu Asn Gln Glu Ala Cys Gln Arg Tyr Glu Val Met Gln Cys Phe 
    210                 215                 220                 


Thr Val Ser Gln Pro Lys Ser Ile Gln Glu Asp Gly Glu Asp Phe Gln 
225                 230                 235                 240 


Ser Cys Leu Ile Cys Ile Ala Arg Arg Leu Pro Arg Pro Pro Ala Ile 
                245                 250                 255     


Thr Gly Val Glu Ser Phe Met Thr Lys Gln Asp Thr Thr Gly Lys Ile 
            260                 265                 270         


Ile Ser Ile Asp Thr Ser Ser Leu Arg Ala Ala Gly Arg Thr Gly Trp 
        275                 280                 285             


Glu Asp Leu Val Arg Lys Cys Ile Tyr Ala Phe Phe Gln Pro Gln Gly 
    290                 295                 300                 


Arg Glu Pro Ser Tyr Ala Arg Gln Leu Phe Gln Glu Val Met Thr Arg 
305                 310                 315                 320 


Gly Thr Ala Ser Ser Pro Ser Tyr Arg Phe Ile Leu Asn Asp Gly Thr 
                325                 330                 335     


Met Leu Ser Ala His Thr Lys Cys Lys Leu Cys Tyr Pro Gln Ser Pro 
            340                 345                 350         


Asp Met Gln Pro Phe Ile Met Gly Ile His Ile Ile Asp Arg Glu His 
        355                 360                 365             


Ser Gly Leu Ser Pro Gln Asp Asp Thr Asn Ser Gly Met Ser Ile Pro 
    370                 375                 380                 


Arg Val Asn Pro Ser Val Asn Pro Ser Ile Ser Pro Ala His Gly Val 
385                 390                 395                 400 


Ala Arg Ser Ser Thr Leu Pro Pro Ser Asn Ser Asn Met Val Ser Thr 
                405                 410                 415     


Arg Ile Asn Arg Gln Gln Ser Ser Asp Leu His Ser Ser Ser His Ser 
            420                 425                 430         


Asn Ser Ser Asn Ser Gln Gly Ser Phe Gly Cys Ser Pro Gly Ser Gln 
        435                 440                 445             


Ile Val Ala Asn Val Ala Leu Asn Gln Gly Gln Ala Ser Ser Gln Ser 
    450                 455                 460                 


Ser Asn Pro Ser Leu Asn Leu Asn Asn Ser Pro Met Glu Gly Thr Gly 
465                 470                 475                 480 


Ile Ser Leu Ala Gln Phe Met Ser Pro Arg Arg Gln Val Thr Ser Gly 
                485                 490                 495     


Leu Ala Thr Arg Pro Arg Met Pro Asn Asn Ser Phe Pro Pro Asn Ile 
            500                 505                 510         


Ser Thr Leu Ser Ser Pro Val Gly Met Thr Ser Ser Ala Cys Asn Asn 
        515                 520                 525             


Asn Asn Arg Ser Tyr Ser Asn Ile Pro Val Thr Ser Leu Gln Gly Met 
    530                 535                 540                 


Asn Glu Gly Pro Asn Asn Ser Val Gly Phe Ser Ala Ser Ser Pro Val 
545                 550                 555                 560 


Leu Arg Gln Met Ser Ser Gln Asn Ser Pro Ser Arg Leu Asn Ile Gln 
                565                 570                 575     


Pro Ala Lys Ala Glu Ser Lys Asp Asn Lys Glu Ile Ala Ser Ile Leu 
            580                 585                 590         


Asn Glu Met Ile Gln Ser Asp Asn Ser Ser Ser Asp Gly Lys Pro Leu 
        595                 600                 605             


Asp Ser Gly Leu Leu His Asn Asn Asp Arg Leu Ser Asp Gly Asp Ser 
    610                 615                 620                 


Lys Tyr Ser Gln Thr Ser His Lys Leu Val Gln Leu Leu Thr Thr Thr 
625                 630                 635                 640 


Ala Glu Gln Gln Leu Arg His Ala Asp Ile Asp Thr Ser Cys Lys Asp 
                645                 650                 655     


Val Leu Ser Cys Thr Gly Thr Ser Asn Ser Ala Ser Ala Asn Ser Ser 
            660                 665                 670         


Gly Gly Ser Cys Pro Ser Ser His Ser Ser Leu Thr Glu Arg His Lys 
        675                 680                 685             


Ile Leu His Arg Leu Leu Gln Glu Gly Ser Pro Ser Asp Ile Thr Thr 
    690                 695                 700                 


Leu Ser Val Glu Pro Asp Lys Lys Asp Ser Ala Ser Thr Ser Val Ser 
705                 710                 715                 720 


Val Thr Gly Gln Val Gln Gly Asn Ser Ser Ile Lys Leu Glu Leu Asp 
                725                 730                 735     


Ala Ser Lys Lys Lys Glu Ser Lys Asp His Gln Leu Leu Arg Tyr Leu 
            740                 745                 750         


Leu Asp Lys Asp Glu Lys Asp Leu Arg Ser Thr Pro Asn Leu Ser Leu 
        755                 760                 765             


Asp Asp Val Lys Val Lys Val Glu Lys Lys Glu Gln Met Asp Pro Cys 
    770                 775                 780                 


Asn Thr Asn Pro Thr Pro Met Thr Lys Pro Thr Pro Glu Glu Ile Lys 
785                 790                 795                 800 


Leu Glu Ala Gln Ser Gln Phe Thr Ala Asp Leu Asp Gln Phe Asp Gln 
                805                 810                 815     


Leu Leu Pro Thr Leu Glu Lys Ala Ala Gln Leu Pro Gly Leu Cys Glu 
            820                 825                 830         


Thr Asp Arg Met Asp Gly Ala Val Thr Ser Val Thr Ile Lys Ser Glu 
        835                 840                 845             


Ile Leu Pro Ala Ser Leu Gln Ser Ala Thr Ala Arg Pro Thr Ser Arg 
    850                 855                 860                 


Leu Asn Arg Leu Pro Glu Leu Glu Leu Glu Ala Ile Asp Asn Gln Phe 
865                 870                 875                 880 


Gly Gln Pro Gly Thr Gly Asp Gln Ile Pro Trp Thr Asn Asn Thr Val 
                885                 890                 895     


Thr Ala Ile Asn Gln Ser Lys Ser Glu Asp Gln Cys Ile Ser Ser Gln 
            900                 905                 910         


Leu Asp Glu Leu Leu Cys Pro Pro Thr Thr Val Glu Gly Arg Asn Asp 
        915                 920                 925             


Glu Lys Ala Leu Leu Glu Gln Leu Val Ser Phe Leu Ser Gly Lys Asp 
    930                 935                 940                 


Glu Thr Glu Leu Ala Glu Leu Asp Arg Ala Leu Gly Ile Asp Lys Leu 
945                 950                 955                 960 


Val Gln Gly Gly Gly Leu Asp Val Leu Ser Glu Arg Phe Pro Pro Gln 
                965                 970                 975     


Gln Ala Thr Pro Pro Leu Ile Met Glu Glu Arg Pro Asn Leu Tyr Ser 
            980                 985                 990         


Gln Pro Tyr Ser Ser Pro Ser Pro  Thr Ala Asn Leu Pro  Ser Pro Phe 
        995                 1000                 1005             


Gln Gly  Met Val Arg Gln Lys  Pro Ser Leu Gly Thr  Met Pro Val 
    1010                 1015                 1020             


Gln Val  Thr Pro Pro Arg Gly  Ala Phe Ser Pro Gly  Met Gly Met 
    1025                 1030                 1035             


Gln Pro  Arg Gln Thr Leu Asn  Arg Pro Pro Ala Ala  Pro Asn Gln 
    1040                 1045                 1050             


Leu Arg  Leu Gln Leu Gln Gln  Arg Leu Gln Gly Gln  Gln Gln Leu 
    1055                 1060                 1065             


Ile His  Gln Asn Arg Gln Ala  Ile Leu Asn Gln Phe  Ala Ala Thr 
    1070                 1075                 1080             


Ala Pro  Val Gly Ile Asn Met  Arg Ser Gly Met Gln  Gln Gln Ile 
    1085                 1090                 1095             


Thr Pro  Gln Pro Pro Leu Asn  Ala Gln Met Leu Ala  Gln Arg Gln 
    1100                 1105                 1110             


Arg Glu  Leu Tyr Ser Gln Gln  His Arg Gln Arg Gln  Leu Ile Gln 
    1115                 1120                 1125             


Gln Gln  Arg Ala Met Leu Met  Arg Gln Gln Ser Phe  Gly Asn Asn 
    1130                 1135                 1140             


Leu Pro  Pro Ser Ser Gly Leu  Pro Val Gln Met Gly  Asn Pro Arg 
    1145                 1150                 1155             


Leu Pro  Gln Gly Ala Pro Gln  Gln Phe Pro Tyr Pro  Pro Asn Tyr 
    1160                 1165                 1170             


Gly Thr  Asn Pro Gly Thr Pro  Pro Ala Ser Thr Ser  Pro Phe Ser 
    1175                 1180                 1185             


Gln Leu  Ala Ala Asn Pro Glu  Ala Ser Leu Ala Asn  Arg Asn Ser 
    1190                 1195                 1200             


Met Val  Ser Arg Gly Met Thr  Gly Asn Ile Gly Gly  Gln Phe Gly 
    1205                 1210                 1215             


Thr Gly  Ile Asn Pro Gln Met  Gln Gln Asn Val Phe  Gln Tyr Pro 
    1220                 1225                 1230             


Gly Ala  Gly Met Val Pro Gln  Gly Glu Ala Asn Phe  Ala Pro Ser 
    1235                 1240                 1245             


Leu Ser  Pro Gly Ser Ser Met  Val Pro Met Pro Ile  Pro Pro Pro 
    1250                 1255                 1260             


Gln Ser  Ser Leu Leu Gln Gln  Thr Pro Pro Ala Ser  Gly Tyr Gln 
    1265                 1270                 1275             


Ser Pro  Asp Met Lys Ala Trp  Gln Gln Gly Ala Ile  Gly Asn Asn 
    1280                 1285                 1290             


Asn Val  Phe Ser Gln Ala Val  Gln Asn Gln Pro Thr  Pro Ala Gln 
    1295                 1300                 1305             


Pro Gly  Val Tyr Asn Asn Met  Ser Ile Thr Val Ser  Met Ala Gly 
    1310                 1315                 1320             


Gly Asn  Thr Asn Val Gln Asn  Met Asn Pro Met Met  Ala Gln Met 
    1325                 1330                 1335             


Gln Met  Ser Ser Leu Gln Met  Pro Gly Met Asn Thr  Val Cys Pro 
    1340                 1345                 1350             


Glu Gln  Ile Asn Asp Pro Ala  Leu Arg His Thr Gly  Leu Tyr Cys 
    1355                 1360                 1365             


Asn Gln  Leu Ser Ser Thr Asp  Leu Leu Lys Thr Glu  Ala Asp Gly 
    1370                 1375                 1380             


Thr Gln  Asp Lys Lys Thr Glu  Glu Phe Phe Ser Val  Val Thr Thr 
    1385                 1390                 1395             


Asp 
    


<210>  18
<211>  1440
<212>  PRT
<213>  homo sapiens

<400>  18

Met Ser Gly Leu Gly Asp Ser Ser Ser Asp Pro Ala Asn Pro Asp Ser 
1               5                   10                  15      


His Lys Arg Lys Gly Ser Pro Cys Asp Thr Leu Ala Ser Ser Thr Glu 
            20                  25                  30          


Lys Arg Arg Arg Glu Gln Glu Asn Lys Tyr Leu Glu Glu Leu Ala Glu 
        35                  40                  45              


Leu Leu Ser Ala Asn Ile Ser Asp Ile Asp Ser Leu Ser Val Lys Pro 
    50                  55                  60                  


Asp Lys Cys Lys Ile Leu Lys Lys Thr Val Asp Gln Ile Gln Leu Met 
65                  70                  75                  80  


Lys Arg Met Glu Gln Glu Lys Ser Thr Thr Asp Asp Asp Val Gln Lys 
                85                  90                  95      


Ser Asp Ile Ser Ser Ser Ser Gln Gly Val Ile Glu Lys Glu Ser Leu 
            100                 105                 110         


Gly Pro Leu Leu Leu Glu Ala Leu Asp Gly Phe Phe Phe Val Val Asn 
        115                 120                 125             


Cys Glu Gly Arg Ile Val Phe Val Ser Glu Asn Val Thr Ser Tyr Leu 
    130                 135                 140                 


Gly Tyr Asn Gln Glu Glu Leu Met Asn Thr Ser Val Tyr Ser Ile Leu 
145                 150                 155                 160 


His Val Gly Asp His Ala Glu Phe Val Lys Asn Leu Leu Pro Lys Ser 
                165                 170                 175     


Leu Val Asn Gly Val Pro Trp Pro Gln Glu Ala Thr Arg Arg Asn Ser 
            180                 185                 190         


His Thr Phe Asn Cys Arg Met Leu Ile His Pro Pro Asp Glu Pro Gly 
        195                 200                 205             


Thr Glu Asn Gln Glu Ala Cys Gln Arg Tyr Glu Val Met Gln Cys Phe 
    210                 215                 220                 


Thr Val Ser Gln Pro Lys Ser Ile Gln Glu Asp Gly Glu Asp Phe Gln 
225                 230                 235                 240 


Ser Cys Leu Ile Cys Ile Ala Arg Arg Leu Pro Arg Pro Pro Ala Ile 
                245                 250                 255     


Thr Gly Val Glu Ser Phe Met Thr Lys Gln Asp Thr Thr Gly Lys Ile 
            260                 265                 270         


Ile Ser Ile Asp Thr Ser Ser Leu Arg Ala Ala Gly Arg Thr Gly Trp 
        275                 280                 285             


Glu Asp Leu Val Arg Lys Cys Ile Tyr Ala Phe Phe Gln Pro Gln Gly 
    290                 295                 300                 


Arg Glu Pro Ser Tyr Ala Arg Gln Leu Phe Gln Glu Val Met Thr Arg 
305                 310                 315                 320 


Gly Thr Ala Ser Ser Pro Ser Tyr Arg Phe Ile Leu Asn Asp Gly Thr 
                325                 330                 335     


Met Leu Ser Ala His Thr Lys Cys Lys Leu Cys Tyr Pro Gln Ser Pro 
            340                 345                 350         


Asp Met Gln Pro Phe Ile Met Gly Ile His Ile Ile Asp Arg Glu His 
        355                 360                 365             


Ser Gly Leu Ser Pro Gln Asp Asp Thr Asn Ser Gly Met Ser Ile Pro 
    370                 375                 380                 


Arg Val Asn Pro Ser Val Asn Pro Ser Ile Ser Pro Ala His Gly Val 
385                 390                 395                 400 


Ala Arg Ser Ser Thr Leu Pro Pro Ser Asn Ser Asn Met Val Ser Thr 
                405                 410                 415     


Arg Ile Asn Arg Gln Gln Ser Ser Asp Leu His Ser Ser Ser His Ser 
            420                 425                 430         


Asn Ser Ser Asn Ser Gln Gly Ser Phe Gly Cys Ser Pro Gly Ser Gln 
        435                 440                 445             


Ile Val Ala Asn Val Ala Leu Asn Gln Gly Gln Ala Ser Ser Gln Ser 
    450                 455                 460                 


Ser Asn Pro Ser Leu Asn Leu Asn Asn Ser Pro Met Glu Gly Thr Gly 
465                 470                 475                 480 


Ile Ser Leu Ala Gln Phe Met Ser Pro Arg Arg Gln Val Thr Ser Gly 
                485                 490                 495     


Leu Ala Thr Arg Pro Arg Met Pro Asn Asn Ser Phe Pro Pro Asn Ile 
            500                 505                 510         


Ser Thr Leu Ser Ser Pro Val Gly Met Thr Ser Ser Ala Cys Asn Asn 
        515                 520                 525             


Asn Asn Arg Ser Tyr Ser Asn Ile Pro Val Thr Ser Leu Gln Gly Met 
    530                 535                 540                 


Asn Glu Gly Pro Asn Asn Ser Val Gly Phe Ser Ala Ser Ser Pro Val 
545                 550                 555                 560 


Leu Arg Gln Met Ser Ser Gln Asn Ser Pro Ser Arg Leu Asn Ile Gln 
                565                 570                 575     


Pro Ala Lys Ala Glu Ser Lys Asp Asn Lys Glu Ile Ala Ser Ile Leu 
            580                 585                 590         


Asn Glu Met Ile Gln Ser Asp Asn Ser Ser Ser Asp Gly Lys Pro Leu 
        595                 600                 605             


Asp Ser Gly Leu Leu His Asn Asn Asp Arg Leu Ser Asp Gly Asp Ser 
    610                 615                 620                 


Lys Tyr Ser Gln Thr Ser His Lys Leu Val Gln Leu Leu Thr Thr Thr 
625                 630                 635                 640 


Ala Glu Gln Gln Leu Arg His Ala Asp Ile Asp Thr Ser Cys Lys Asp 
                645                 650                 655     


Val Leu Ser Cys Thr Gly Thr Ser Asn Ser Ala Ser Ala Asn Ser Ser 
            660                 665                 670         


Gly Gly Ser Cys Pro Ser Ser His Ser Ser Leu Thr Glu Arg His Lys 
        675                 680                 685             


Ile Leu His Arg Leu Leu Gln Glu Gly Ser Pro Ser Asp Ile Thr Thr 
    690                 695                 700                 


Leu Ser Val Glu Pro Asp Lys Lys Asp Ser Ala Ser Thr Ser Val Ser 
705                 710                 715                 720 


Val Thr Gly Gln Val Gln Gly Asn Ser Ser Ile Lys Leu Glu Leu Asp 
                725                 730                 735     


Ala Ser Lys Lys Lys Glu Ser Lys Asp His Gln Leu Leu Arg Tyr Leu 
            740                 745                 750         


Leu Asp Lys Asp Glu Lys Asp Leu Arg Ser Thr Pro Asn Leu Ser Leu 
        755                 760                 765             


Asp Asp Val Lys Val Lys Val Glu Lys Lys Glu Gln Met Asp Pro Cys 
    770                 775                 780                 


Asn Thr Asn Pro Thr Pro Met Thr Lys Pro Thr Pro Glu Glu Ile Lys 
785                 790                 795                 800 


Leu Glu Ala Gln Ser Gln Phe Thr Ala Asp Leu Asp Gln Phe Asp Gln 
                805                 810                 815     


Leu Leu Pro Thr Leu Glu Lys Ala Ala Gln Leu Pro Gly Leu Cys Glu 
            820                 825                 830         


Thr Asp Arg Met Asp Gly Ala Val Thr Ser Val Thr Ile Lys Ser Glu 
        835                 840                 845             


Ile Leu Pro Ala Ser Leu Gln Ser Ala Thr Ala Arg Pro Thr Ser Arg 
    850                 855                 860                 


Leu Asn Arg Leu Pro Glu Leu Glu Leu Glu Ala Ile Asp Asn Gln Phe 
865                 870                 875                 880 


Gly Gln Pro Gly Thr Gly Asp Gln Ile Pro Trp Thr Asn Asn Thr Val 
                885                 890                 895     


Thr Ala Ile Asn Gln Ser Lys Ser Glu Asp Gln Cys Ile Ser Ser Gln 
            900                 905                 910         


Leu Asp Glu Leu Leu Cys Pro Pro Thr Thr Val Glu Gly Arg Asn Asp 
        915                 920                 925             


Glu Lys Ala Leu Leu Glu Gln Leu Val Ser Phe Leu Ser Gly Lys Asp 
    930                 935                 940                 


Glu Thr Glu Leu Ala Glu Leu Asp Arg Ala Leu Gly Ile Asp Lys Leu 
945                 950                 955                 960 


Val Gln Gly Gly Gly Leu Asp Val Leu Ser Glu Arg Phe Pro Pro Gln 
                965                 970                 975     


Gln Ala Thr Pro Pro Leu Ile Met Glu Glu Arg Pro Asn Leu Tyr Ser 
            980                 985                 990         


Gln Pro Tyr Ser Ser Pro Ser Pro  Thr Ala Asn Leu Pro  Ser Pro Phe 
        995                 1000                 1005             


Gln Gly  Met Val Arg Gln Lys  Pro Ser Leu Gly Thr  Met Pro Val 
    1010                 1015                 1020             


Gln Val  Thr Pro Pro Arg Gly  Ala Phe Ser Pro Gly  Met Gly Met 
    1025                 1030                 1035             


Gln Pro  Arg Gln Thr Leu Asn  Arg Pro Pro Ala Ala  Pro Asn Gln 
    1040                 1045                 1050             


Leu Arg  Leu Gln Leu Gln Gln  Arg Leu Gln Gly Gln  Gln Gln Leu 
    1055                 1060                 1065             


Ile His  Gln Asn Arg Gln Ala  Ile Leu Asn Gln Phe  Ala Ala Thr 
    1070                 1075                 1080             


Ala Pro  Val Gly Ile Asn Met  Arg Ser Gly Met Gln  Gln Gln Ile 
    1085                 1090                 1095             


Thr Pro  Gln Pro Pro Leu Asn  Ala Gln Met Leu Ala  Gln Arg Gln 
    1100                 1105                 1110             


Arg Glu  Leu Tyr Ser Gln Gln  His Arg Gln Arg Gln  Leu Ile Gln 
    1115                 1120                 1125             


Gln Gln  Arg Ala Met Leu Met  Arg Gln Gln Ser Phe  Gly Asn Asn 
    1130                 1135                 1140             


Leu Pro  Pro Ser Ser Gly Leu  Pro Val Gln Met Gly  Asn Pro Arg 
    1145                 1150                 1155             


Leu Pro  Gln Gly Ala Pro Gln  Gln Phe Pro Tyr Pro  Pro Asn Tyr 
    1160                 1165                 1170             


Gly Thr  Asn Pro Gly Thr Pro  Pro Ala Ser Thr Ser  Pro Phe Ser 
    1175                 1180                 1185             


Gln Leu  Ala Ala Asn Pro Glu  Ala Ser Leu Ala Asn  Arg Asn Ser 
    1190                 1195                 1200             


Met Val  Ser Arg Gly Met Thr  Gly Asn Ile Gly Gly  Gln Phe Gly 
    1205                 1210                 1215             


Thr Gly  Ile Asn Pro Gln Met  Gln Gln Asn Val Phe  Gln Tyr Pro 
    1220                 1225                 1230             


Gly Ala  Gly Met Val Pro Gln  Gly Glu Ala Asn Phe  Ala Pro Ser 
    1235                 1240                 1245             


Leu Ser  Pro Gly Ser Ser Met  Val Pro Met Pro Ile  Pro Pro Pro 
    1250                 1255                 1260             


Gln Ser  Ser Leu Leu Gln Gln  Thr Pro Pro Ala Ser  Gly Tyr Gln 
    1265                 1270                 1275             


Ser Pro  Asp Met Lys Ala Trp  Gln Gln Gly Ala Ile  Gly Asn Asn 
    1280                 1285                 1290             


Asn Val  Phe Ser Gln Ala Val  Gln Asn Gln Pro Thr  Pro Ala Gln 
    1295                 1300                 1305             


Pro Gly  Val Tyr Asn Asn Met  Ser Ile Thr Val Ser  Met Ala Gly 
    1310                 1315                 1320             


Gly Asn  Thr Asn Val Gln Asn  Met Asn Pro Met Met  Ala Gln Met 
    1325                 1330                 1335             


Gln Met  Ser Ser Leu Gln Met  Pro Gly Met Asn Thr  Val Cys Pro 
    1340                 1345                 1350             


Glu Gln  Ile Asn Asp Pro Ala  Leu Arg His Thr Gly  Leu Tyr Cys 
    1355                 1360                 1365             


Asn Gln  Leu Ser Ser Thr Asp  Leu Leu Lys Thr Glu  Ala Asp Gly 
    1370                 1375                 1380             


Thr Gln  Val Gln Gln Val Gln  Val Phe Ala Asp Val  Gln Cys Thr 
    1385                 1390                 1395             


Val Asn  Leu Val Gly Gly Asp  Pro Tyr Leu Asn Gln  Pro Gly Pro 
    1400                 1405                 1410             


Leu Gly  Thr Gln Lys Pro Thr  Ser Gly Pro Gln Thr  Pro Gln Ala 
    1415                 1420                 1425             


Gln Gln  Lys Ser Leu Leu Gln  Gln Leu Leu Thr Glu  
    1430                 1435                 1440 


<210>  19
<211>  388
<212>  PRT
<213>  homo sapiens

<400>  19

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys 
                325                 330                 335     


Asn Ile Leu Ser Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala 
            340                 345                 350         


Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln 
        355                 360                 365             


Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu 
    370                 375                 380                 


Asn Gln Leu Trp 
385             


<210>  20
<211>  376
<212>  PRT
<213>  homo sapiens

<400>  20

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Pro Val Phe 
                325                 330                 335     


Leu Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe 
            340                 345                 350         


Cys Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp 
        355                 360                 365             


Lys Thr Arg Leu Asn Gln Leu Trp 
    370                 375     


<210>  21
<211>  290
<212>  PRT
<213>  homo sapiens

<400>  21

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Trp Ile Phe His Leu 
            260                 265                 270         


Ser His Pro Asp Leu Phe Asp Cys Asp Ser Tyr Pro Gly His Ile Gly 
        275                 280                 285             


Cys Ser 
    290 


<210>  22
<211>  321
<212>  PRT
<213>  homo sapiens

<400>  22

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile 
                245                 250                 255     


Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val Val Val Asp Ser 
            260                 265                 270         


Arg Leu Lys Lys Gln Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln 
        275                 280                 285             


Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp 
    290                 295                 300                 


Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu 
305                 310                 315                 320 


Trp 
    


<210>  23
<211>  187
<212>  PRT
<213>  homo sapiens

<400>  23

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly 
    50                  55                  60                  


Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu 
65                  70                  75                  80  


Arg Ala Thr Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys 
                85                  90                  95      


Arg Val Lys His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp 
            100                 105                 110         


Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val 
        115                 120                 125             


Thr Leu Val Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser 
    130                 135                 140                 


Pro Val Phe Leu Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg 
145                 150                 155                 160 


His Gln Phe Cys Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu 
                165                 170                 175     


Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu Trp 
            180                 185         


<210>  24
<211>  101
<212>  PRT
<213>  homo sapiens

<400>  24

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly 
    50                  55                  60                  


Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Trp Ile 
65                  70                  75                  80  


Phe His Leu Ser His Pro Asp Leu Phe Asp Cys Asp Ser Tyr Pro Gly 
                85                  90                  95      


His Ile Gly Cys Ser 
            100     


<210>  25
<211>  298
<212>  PRT
<213>  homo sapiens

<400>  25

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Leu Lys Pro Glu Ala Trp Leu Ser Cys Gly 
        115                 120                 125             


Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly 
    130                 135                 140                 


Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu 
145                 150                 155                 160 


Gln Arg Gly Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr 
                165                 170                 175     


Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Ala Gly Glu Ala Ala Gly 
            180                 185                 190         


Leu Ser Cys Arg Val Lys His Ser Ser Leu Gly Gly His Asp Leu Ile 
        195                 200                 205             


Ile His Trp Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr 
    210                 215                 220                 


Val Ile Val Thr Leu Val Ile Leu Val Val Val Asp Ser Arg Leu Lys 
225                 230                 235                 240 


Lys Gln Ser Ser Asn Lys Asn Ile Leu Ser Pro His Thr Pro Ser Pro 
                245                 250                 255     


Val Phe Leu Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His 
            260                 265                 270         


Gln Phe Cys Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys 
        275                 280                 285             


Lys Trp Lys Thr Arg Leu Asn Gln Leu Trp 
    290                 295             


<210>  26
<211>  286
<212>  PRT
<213>  homo sapiens

<400>  26

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Leu Lys Pro Glu Ala Trp Leu Ser Cys Gly 
        115                 120                 125             


Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly 
    130                 135                 140                 


Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu 
145                 150                 155                 160 


Gln Arg Gly Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr 
                165                 170                 175     


Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Ala Gly Glu Ala Ala Gly 
            180                 185                 190         


Leu Ser Cys Arg Val Lys His Ser Ser Leu Gly Gly His Asp Leu Ile 
        195                 200                 205             


Ile His Trp Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr 
    210                 215                 220                 


Val Ile Val Thr Leu Val Ile Leu Val Val Val Asp Ser Arg Leu Lys 
225                 230                 235                 240 


Lys Gln Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln Asp Thr Lys 
                245                 250                 255     


Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp Ile Lys Asn 
            260                 265                 270         


Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu Trp 
        275                 280                 285     


<210>  27
<211>  230
<212>  PRT
<213>  homo sapiens

<400>  27

Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu Asn 
1               5                   10                  15      


Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu Glu 
            20                  25                  30          


Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His Ser 
        35                  40                  45              


Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr His 
    50                  55                  60                  


Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp Ser 
65                  70                  75                  80  


His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu Phe 
                85                  90                  95      


Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala Gly 
            100                 105                 110         


Gln Phe Gln Leu Glu Leu Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro 
        115                 120                 125             


Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe 
    130                 135                 140                 


Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly Gly Tyr Ser Ile 
145                 150                 155                 160 


Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu 
                165                 170                 175     


Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Pro Val Phe Leu Met 
            180                 185                 190         


Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu 
        195                 200                 205             


Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr 
    210                 215                 220                 


Arg Leu Asn Gln Leu Trp 
225                 230 


<210>  28
<211>  199
<212>  PRT
<213>  homo sapiens

<400>  28

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly 
    50                  55                  60                  


Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu 
65                  70                  75                  80  


Arg Ala Thr Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys 
                85                  90                  95      


Arg Val Lys His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp 
            100                 105                 110         


Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val 
        115                 120                 125             


Thr Leu Val Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser 
    130                 135                 140                 


Ser Asn Lys Asn Ile Leu Ser Pro His Thr Pro Ser Pro Val Phe Leu 
145                 150                 155                 160 


Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys 
                165                 170                 175     


Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys 
            180                 185                 190         


Thr Arg Leu Asn Gln Leu Trp 
        195                 


<210>  29
<211>  144
<212>  PRT
<213>  homo sapiens

<400>  29

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Gly Tyr Ser Ile Phe Leu 
    50                  55                  60                  


Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val Val 
65                  70                  75                  80  


Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys Asn Ile Leu Ser 
                85                  90                  95      


Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln Asp 
            100                 105                 110         


Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp Ile 
        115                 120                 125             


Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu Trp 
    130                 135                 140                 


<210>  30
<211>  132
<212>  PRT
<213>  homo sapiens

<400>  30

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Gly Tyr Ser Ile Phe Leu 
    50                  55                  60                  


Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val Val 
65                  70                  75                  80  


Val Asp Ser Arg Leu Lys Lys Gln Ser Pro Val Phe Leu Met Gly Ala 
                85                  90                  95      


Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln 
            100                 105                 110         


Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu 
        115                 120                 125             


Asn Gln Leu Trp 
    130         


<210>  31
<211>  289
<212>  PRT
<213>  homo sapiens

<400>  31

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Asp Pro Phe Glu Ile Gln Ile Leu Ala Gly Cys Arg Met 
            20                  25                  30          


Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly Ser Asp Phe 
        35                  40                  45              


Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly Ala Gly Ile 
    50                  55                  60                  


Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu Asp Ile Lys 
65                  70                  75                  80  


Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg Phe Leu Ala 
                85                  90                  95      


Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys Val Lys Pro 
            100                 105                 110         


Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly Arg Leu Gln 
        115                 120                 125             


Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met 
    130                 135                 140                 


Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg Gly Asp Val 
145                 150                 155                 160 


Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val 
                165                 170                 175     


Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser 
            180                 185                 190         


Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr Ser Ile Phe 
        195                 200                 205             


Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val 
    210                 215                 220                 


Val Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys Asn Ile Leu 
225                 230                 235                 240 


Ser Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln 
                245                 250                 255     


Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp 
            260                 265                 270         


Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu 
        275                 280                 285             


Trp 
    


<210>  32
<211>  365
<212>  PRT
<213>  homo sapiens

<400>  32

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  33
<211>  472
<212>  PRT
<213>  homo sapiens

<400>  33

Met Thr Thr Cys Ser Arg Gln Phe Thr Ser Ser Ser Ser Met Lys Gly 
1               5                   10                  15      


Ser Cys Gly Ile Gly Gly Gly Ile Gly Gly Gly Ser Ser Arg Ile Ser 
            20                  25                  30          


Ser Val Leu Ala Gly Gly Ser Cys Arg Ala Pro Ser Thr Tyr Gly Gly 
        35                  40                  45              


Gly Leu Ser Val Ser Ser Ser Arg Phe Ser Ser Gly Gly Ala Tyr Gly 
    50                  55                  60                  


Leu Gly Gly Gly Tyr Gly Gly Gly Phe Ser Ser Ser Ser Ser Ser Phe 
65                  70                  75                  80  


Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly Gly Leu Gly Ala Gly Leu 
                85                  90                  95      


Gly Gly Gly Phe Gly Gly Gly Phe Ala Gly Gly Asp Gly Leu Leu Val 
            100                 105                 110         


Gly Ser Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser 
        115                 120                 125             


Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu 
    130                 135                 140                 


Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Arg Pro Ala Glu Ile Lys 
145                 150                 155                 160 


Asp Tyr Ser Pro Tyr Phe Lys Thr Ile Glu Asp Leu Arg Asn Lys Ile 
                165                 170                 175     


Leu Thr Ala Thr Val Asp Asn Ala Asn Val Leu Leu Gln Ile Asp Asn 
            180                 185                 190         


Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Tyr Glu Thr Glu Leu 
        195                 200                 205             


Asn Leu Arg Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val 
    210                 215                 220                 


Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile Glu 
225                 230                 235                 240 


Ser Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu 
                245                 250                 255     


Met Asn Ala Leu Arg Gly Gln Val Gly Gly Asp Val Asn Val Glu Met 
            260                 265                 270         


Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met Arg 
        275                 280                 285             


Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu Glu 
    290                 295                 300                 


Trp Phe Phe Thr Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr Asn 
305                 310                 315                 320 


Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg Arg 
                325                 330                 335     


Thr Met Gln Asn Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys 
            340                 345                 350         


Ala Ser Leu Glu Asn Ser Leu Glu Glu Thr Lys Gly Arg Tyr Cys Met 
        355                 360                 365             


Gln Leu Ala Gln Ile Gln Glu Met Ile Gly Ser Val Glu Glu Gln Leu 
    370                 375                 380                 


Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys Ile 
385                 390                 395                 400 


Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg 
                405                 410                 415     


Arg Leu Leu Glu Gly Glu Asp Ala His Leu Ser Ser Ser Gln Phe Ser 
            420                 425                 430         


Ser Gly Ser Gln Ser Ser Arg Asp Val Thr Ser Ser Ser Arg Gln Ile 
        435                 440                 445             


Arg Thr Lys Val Met Asp Val His Asp Gly Lys Val Val Ser Thr His 
    450                 455                 460                 


Glu Gln Val Leu Arg Thr Lys Asn 
465                 470         


<210>  34
<211>  372
<212>  PRT
<213>  homo sapiens

<400>  34

Met Leu Ala Asn Ser Ser Ser Thr Asn Ser Ser Val Leu Pro Cys Pro 
1               5                   10                  15      


Asp Tyr Arg Pro Thr His Arg Leu His Leu Val Val Tyr Ser Leu Val 
            20                  25                  30          


Leu Ala Ala Gly Leu Pro Leu Asn Ala Leu Ala Leu Trp Val Phe Leu 
        35                  40                  45              


Arg Ala Leu Arg Val His Ser Val Val Ser Val Tyr Met Cys Asn Leu 
    50                  55                  60                  


Ala Ala Ser Asp Leu Leu Phe Thr Leu Ser Leu Pro Val Arg Leu Ser 
65                  70                  75                  80  


Tyr Tyr Ala Leu His His Trp Pro Phe Pro Asp Leu Leu Cys Gln Thr 
                85                  90                  95      


Thr Gly Ala Ile Phe Gln Met Asn Met Tyr Gly Ser Cys Ile Phe Leu 
            100                 105                 110         


Met Leu Ile Asn Val Asp Arg Tyr Ala Ala Ile Val His Pro Leu Arg 
        115                 120                 125             


Leu Arg His Leu Arg Arg Pro Arg Val Ala Arg Leu Leu Cys Leu Gly 
    130                 135                 140                 


Val Trp Ala Leu Ile Leu Val Phe Ala Val Pro Ala Ala Arg Val His 
145                 150                 155                 160 


Arg Pro Ser Arg Cys Arg Tyr Arg Asp Leu Glu Val Arg Leu Cys Phe 
                165                 170                 175     


Glu Ser Phe Ser Asp Glu Leu Trp Lys Gly Arg Leu Leu Pro Leu Val 
            180                 185                 190         


Leu Leu Ala Glu Ala Leu Gly Phe Leu Leu Pro Leu Ala Ala Val Val 
        195                 200                 205             


Tyr Ser Ser Gly Arg Val Phe Trp Thr Leu Ala Arg Pro Asp Ala Thr 
    210                 215                 220                 


Gln Ser Gln Arg Arg Arg Lys Thr Val Arg Leu Leu Leu Ala Asn Leu 
225                 230                 235                 240 


Val Ile Phe Leu Leu Cys Phe Val Pro Tyr Asn Ser Thr Leu Ala Val 
                245                 250                 255     


Tyr Gly Leu Leu Arg Ser Lys Leu Val Ala Ala Ser Val Pro Ala Arg 
            260                 265                 270         


Asp Arg Val Arg Gly Val Leu Met Val Met Val Leu Leu Ala Gly Ala 
        275                 280                 285             


Asn Cys Val Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ala Glu Gly Phe 
    290                 295                 300                 


Arg Asn Thr Leu Arg Gly Leu Gly Thr Pro His Arg Ala Arg Thr Ser 
305                 310                 315                 320 


Ala Thr Asn Gly Thr Arg Ala Ala Leu Ala Gln Ser Glu Arg Ser Ala 
                325                 330                 335     


Val Thr Thr Asp Ala Thr Arg Pro Asp Ala Ala Ser Gln Gly Leu Leu 
            340                 345                 350         


Arg Pro Ser Asp Ser His Ser Leu Ser Ser Phe Thr Gln Cys Pro Gln 
        355                 360                 365             


Asp Ser Ala Leu 
    370         


<210>  35
<211>  725
<212>  PRT
<213>  homo sapiens

<400>  35

Met Glu Ser Gly Arg Gly Ser Ser Thr Pro Pro Gly Pro Ile Ala Ala 
1               5                   10                  15      


Leu Gly Met Pro Asp Thr Gly Pro Gly Ser Ser Ser Leu Gly Lys Leu 
            20                  25                  30          


Gln Ala Leu Pro Val Gly Pro Arg Ala His Cys Gly Asp Pro Val Ser 
        35                  40                  45              


Leu Ala Ala Ala Gly Asp Gly Ser Pro Asp Ile Gly Pro Thr Gly Glu 
    50                  55                  60                  


Leu Ser Gly Ser Leu Lys Ile Pro Asn Arg Asp Ser Gly Ile Asp Ser 
65                  70                  75                  80  


Pro Ser Ser Ser Val Ala Gly Glu Asn Phe Pro Cys Glu Glu Gly Leu 
                85                  90                  95      


Glu Ala Gly Pro Ser Pro Thr Val Leu Gly Ala His Ala Glu Met Ala 
            100                 105                 110         


Leu Asp Ser Gln Val Pro Lys Val Thr Pro Gln Glu Glu Ala Asp Ser 
        115                 120                 125             


Asp Val Gly Glu Glu Pro Asp Ser Glu Asn Thr Pro Gln Lys Ala Asp 
    130                 135                 140                 


Lys Asp Ala Gly Leu Ala Gln His Ser Gly Pro Gln Lys Leu Leu His 
145                 150                 155                 160 


Ile Ala Gln Glu Leu Leu His Thr Glu Glu Thr Tyr Val Lys Arg Leu 
                165                 170                 175     


His Leu Leu Asp Gln Val Phe Cys Thr Arg Leu Thr Asp Ala Gly Ile 
            180                 185                 190         


Pro Pro Glu Val Ile Met Gly Ile Phe Ser Asn Ile Ser Ser Ile His 
        195                 200                 205             


Arg Phe His Gly Gln Phe Leu Leu Pro Glu Leu Lys Thr Arg Ile Thr 
    210                 215                 220                 


Glu Glu Trp Asp Thr Asn Pro Arg Leu Gly Asp Ile Leu Gln Lys Leu 
225                 230                 235                 240 


Ala Pro Phe Leu Lys Met Tyr Gly Glu Tyr Val Lys Asn Phe Asp Arg 
                245                 250                 255     


Ala Val Gly Leu Val Ser Thr Trp Thr Gln Arg Ser Pro Leu Phe Lys 
            260                 265                 270         


Asp Val Val His Ser Ile Gln Lys Gln Glu Val Cys Gly Asn Leu Thr 
        275                 280                 285             


Leu Gln His His Met Leu Glu Pro Val Gln Arg Val Pro Arg Tyr Glu 
    290                 295                 300                 


Leu Leu Leu Lys Asp Tyr Leu Lys Arg Leu Pro Gln Asp Ala Pro Asp 
305                 310                 315                 320 


Arg Lys Asp Ala Glu Arg Ser Leu Glu Leu Ile Ser Thr Ala Ala Asn 
                325                 330                 335     


His Ser Asn Ala Ala Ile Arg Lys Val Glu Lys Met His Lys Leu Leu 
            340                 345                 350         


Glu Val Tyr Glu Gln Leu Gly Gly Glu Glu Asp Ile Val Asn Pro Ala 
        355                 360                 365             


Asn Glu Leu Ile Lys Glu Gly Gln Ile Gln Lys Leu Ser Ala Lys Asn 
    370                 375                 380                 


Gly Thr Pro Gln Asp Arg His Leu Phe Leu Phe Asn Ser Met Ile Leu 
385                 390                 395                 400 


Tyr Cys Val Pro Lys Leu Arg Leu Met Gly Gln Lys Phe Ser Val Arg 
                405                 410                 415     


Glu Lys Met Asp Ile Ser Gly Leu Gln Val Gln Asp Ile Val Lys Pro 
            420                 425                 430         


Asn Thr Ala His Thr Phe Ile Ile Thr Gly Arg Lys Arg Ser Leu Glu 
        435                 440                 445             


Leu Gln Thr Arg Thr Glu Glu Glu Lys Lys Glu Trp Ile Gln Ile Ile 
    450                 455                 460                 


Gln Ala Thr Ile Glu Lys His Lys Gln Asn Ser Glu Thr Phe Lys Ala 
465                 470                 475                 480 


Phe Gly Gly Ala Phe Ser Gln Asp Glu Asp Pro Ser Leu Ser Pro Asp 
                485                 490                 495     


Met Pro Ile Thr Ser Thr Ser Pro Val Glu Pro Val Val Thr Thr Glu 
            500                 505                 510         


Gly Ser Ser Gly Ala Ala Gly Leu Glu Pro Arg Lys Leu Ser Ser Lys 
        515                 520                 525             


Thr Arg Arg Asp Lys Glu Lys Gln Ser Cys Lys Ser Cys Gly Glu Thr 
    530                 535                 540                 


Phe Asn Ser Ile Thr Lys Arg Arg His His Cys Lys Leu Cys Gly Ala 
545                 550                 555                 560 


Val Ile Cys Gly Lys Cys Ser Glu Phe Lys Ala Glu Asn Ser Arg Gln 
                565                 570                 575     


Ser Arg Val Cys Arg Asp Cys Phe Leu Thr Gln Pro Val Ala Pro Glu 
            580                 585                 590         


Ser Thr Glu Lys Thr Pro Thr Ala Asp Pro Gln Pro Ser Leu Leu Cys 
        595                 600                 605             


Gly Pro Leu Arg Leu Ser Glu Ser Gly Glu Thr Trp Ser Glu Val Trp 
    610                 615                 620                 


Ala Ala Ile Pro Met Ser Asp Pro Gln Val Leu His Leu Gln Gly Gly 
625                 630                 635                 640 


Ser Gln Asp Gly Arg Leu Pro Arg Thr Ile Pro Leu Pro Ser Cys Lys 
                645                 650                 655     


Leu Ser Val Pro Asp Pro Glu Glu Arg Leu Asp Ser Gly His Val Trp 
            660                 665                 670         


Lys Leu Gln Trp Ala Lys Gln Ser Trp Tyr Leu Ser Ala Ser Ser Ala 
        675                 680                 685             


Glu Leu Gln Gln Gln Trp Leu Glu Thr Leu Ser Thr Ala Ala His Gly 
    690                 695                 700                 


Asp Thr Ala Gln Asp Ser Pro Gly Ala Leu Gln Leu Gln Val Pro Met 
705                 710                 715                 720 


Gly Ala Ala Ala Pro 
                725 


<210>  36
<211>  725
<212>  PRT
<213>  homo sapiens

<400>  36

Met Glu Ser Gly Arg Gly Ser Ser Thr Pro Pro Gly Pro Ile Ala Ala 
1               5                   10                  15      


Leu Gly Met Pro Asp Thr Gly Pro Gly Ser Ser Ser Leu Gly Lys Leu 
            20                  25                  30          


Gln Ala Leu Pro Val Gly Pro Arg Ala His Cys Gly Asp Pro Val Ser 
        35                  40                  45              


Leu Ala Ala Ala Gly Asp Gly Ser Pro Asp Ile Gly Pro Thr Gly Glu 
    50                  55                  60                  


Leu Ser Gly Ser Leu Lys Ile Pro Asn Arg Asp Ser Gly Ile Asp Ser 
65                  70                  75                  80  


Pro Ser Ser Ser Val Ala Gly Glu Asn Phe Pro Cys Glu Glu Gly Leu 
                85                  90                  95      


Glu Ala Gly Pro Ser Pro Thr Val Leu Gly Ala His Ala Glu Met Ala 
            100                 105                 110         


Leu Asp Ser Gln Val Pro Lys Val Thr Pro Gln Glu Glu Ala Asp Ser 
        115                 120                 125             


Asp Val Gly Glu Glu Pro Asp Ser Glu Asn Thr Pro Gln Lys Ala Asp 
    130                 135                 140                 


Lys Asp Ala Gly Leu Ala Gln His Ser Gly Pro Gln Lys Leu Leu His 
145                 150                 155                 160 


Ile Ala Gln Glu Leu Leu His Thr Glu Glu Thr Tyr Val Lys Arg Leu 
                165                 170                 175     


His Leu Leu Asp Gln Val Phe Cys Thr Arg Leu Thr Asp Ala Gly Ile 
            180                 185                 190         


Pro Pro Glu Val Ile Met Gly Ile Phe Ser Asn Ile Ser Ser Ile His 
        195                 200                 205             


Arg Phe His Gly Gln Phe Leu Leu Pro Glu Leu Lys Thr Arg Ile Thr 
    210                 215                 220                 


Glu Glu Trp Asp Thr Asn Pro Arg Leu Gly Asp Ile Leu Gln Lys Leu 
225                 230                 235                 240 


Ala Pro Phe Leu Lys Met Tyr Gly Glu Tyr Val Lys Asn Phe Asp Arg 
                245                 250                 255     


Ala Val Gly Leu Val Ser Thr Trp Thr Gln Arg Ser Pro Leu Phe Lys 
            260                 265                 270         


Asp Val Val His Ser Ile Gln Lys Gln Glu Val Cys Gly Asn Leu Thr 
        275                 280                 285             


Leu Gln His His Met Leu Glu Pro Val Gln Arg Val Pro Arg Tyr Glu 
    290                 295                 300                 


Leu Leu Leu Lys Asp Tyr Leu Lys Arg Leu Pro Gln Asp Ala Pro Asp 
305                 310                 315                 320 


Arg Lys Asp Ala Glu Arg Ser Leu Glu Leu Ile Ser Thr Ala Ala Asn 
                325                 330                 335     


His Ser Asn Ala Ala Ile Arg Lys Val Glu Lys Met His Lys Leu Leu 
            340                 345                 350         


Glu Val Tyr Glu Gln Leu Gly Gly Glu Glu Asp Ile Val Asn Pro Ala 
        355                 360                 365             


Asn Glu Leu Ile Lys Glu Gly Gln Ile Gln Lys Leu Ser Ala Lys Asn 
    370                 375                 380                 


Gly Thr Pro Gln Asp Arg His Leu Phe Leu Phe Asn Ser Met Ile Leu 
385                 390                 395                 400 


Tyr Cys Val Pro Lys Leu Arg Leu Met Gly Gln Lys Phe Ser Val Arg 
                405                 410                 415     


Glu Lys Met Asp Ile Ser Gly Leu Gln Val Gln Asp Ile Val Lys Pro 
            420                 425                 430         


Asn Thr Ala His Thr Phe Ile Ile Thr Gly Arg Lys Arg Ser Leu Glu 
        435                 440                 445             


Leu Gln Thr Arg Thr Glu Glu Glu Lys Lys Glu Trp Ile Gln Ile Ile 
    450                 455                 460                 


Gln Ala Thr Ile Glu Lys His Lys Gln Asn Ser Glu Thr Phe Lys Ala 
465                 470                 475                 480 


Phe Gly Gly Ala Phe Ser Gln Asp Glu Asp Pro Ser Leu Ser Pro Asp 
                485                 490                 495     


Met Pro Ile Thr Ser Thr Ser Pro Val Glu Pro Val Val Thr Thr Glu 
            500                 505                 510         


Gly Ser Ser Gly Ala Ala Gly Leu Glu Pro Arg Lys Leu Ser Ser Lys 
        515                 520                 525             


Thr Arg Arg Asp Lys Glu Lys Gln Ser Cys Lys Ser Cys Gly Glu Thr 
    530                 535                 540                 


Phe Asn Ser Ile Thr Lys Arg Arg His His Cys Lys Leu Cys Gly Ala 
545                 550                 555                 560 


Val Ile Cys Gly Lys Cys Ser Glu Phe Lys Ala Glu Asn Ser Arg Gln 
                565                 570                 575     


Ser Arg Val Cys Arg Asp Cys Phe Leu Thr Gln Pro Val Ala Pro Glu 
            580                 585                 590         


Ser Thr Glu Lys Thr Pro Thr Ala Asp Pro Gln Pro Ser Leu Leu Cys 
        595                 600                 605             


Gly Pro Leu Arg Leu Ser Glu Ser Gly Glu Thr Trp Ser Glu Val Trp 
    610                 615                 620                 


Ala Ala Ile Pro Met Ser Asp Pro Gln Val Leu His Leu Gln Gly Gly 
625                 630                 635                 640 


Ser Gln Asp Gly Arg Leu Pro Arg Thr Ile Pro Leu Pro Ser Cys Lys 
                645                 650                 655     


Leu Ser Val Pro Asp Pro Glu Glu Arg Leu Asp Ser Gly His Val Trp 
            660                 665                 670         


Lys Leu Gln Trp Ala Lys Gln Ser Trp Tyr Leu Ser Ala Ser Ser Ala 
        675                 680                 685             


Glu Leu Gln Gln Gln Trp Leu Glu Thr Leu Ser Thr Ala Ala His Gly 
    690                 695                 700                 


Asp Thr Ala Gln Asp Ser Pro Gly Ala Leu Gln Leu Gln Val Pro Met 
705                 710                 715                 720 


Gly Ala Ala Ala Pro 
                725 


<210>  37
<211>  724
<212>  PRT
<213>  homo sapiens

<400>  37

Met Glu Ser Gly Arg Gly Ser Ser Thr Pro Pro Gly Pro Ile Ala Ala 
1               5                   10                  15      


Leu Gly Met Pro Asp Thr Gly Pro Gly Ser Ser Ser Leu Gly Lys Leu 
            20                  25                  30          


Gln Ala Leu Pro Val Gly Pro Arg Ala His Cys Gly Asp Pro Val Ser 
        35                  40                  45              


Leu Ala Ala Ala Gly Asp Gly Ser Pro Asp Ile Gly Pro Thr Gly Glu 
    50                  55                  60                  


Leu Ser Gly Ser Leu Lys Ile Pro Asn Arg Asp Ser Gly Ile Asp Ser 
65                  70                  75                  80  


Pro Ser Ser Ser Val Ala Gly Glu Asn Phe Pro Cys Glu Glu Gly Leu 
                85                  90                  95      


Glu Ala Gly Pro Ser Pro Thr Val Leu Gly Ala His Ala Glu Met Ala 
            100                 105                 110         


Leu Asp Ser Gln Val Pro Lys Val Thr Pro Gln Glu Glu Ala Asp Ser 
        115                 120                 125             


Asp Val Gly Glu Glu Pro Asp Ser Glu Asn Thr Pro Gln Lys Ala Asp 
    130                 135                 140                 


Lys Asp Ala Gly Leu Ala Gln His Ser Gly Pro Gln Lys Leu Leu His 
145                 150                 155                 160 


Ile Ala Gln Glu Leu Leu His Thr Glu Glu Thr Tyr Val Lys Arg Leu 
                165                 170                 175     


His Leu Leu Asp Gln Val Phe Cys Thr Arg Leu Thr Asp Ala Gly Ile 
            180                 185                 190         


Pro Pro Glu Val Ile Met Gly Ile Phe Ser Asn Ile Ser Ser Ile His 
        195                 200                 205             


Arg Phe His Gly Gln Phe Leu Leu Pro Glu Leu Lys Thr Arg Ile Thr 
    210                 215                 220                 


Glu Glu Trp Asp Thr Asn Pro Arg Leu Gly Asp Ile Leu Gln Lys Leu 
225                 230                 235                 240 


Ala Pro Phe Leu Lys Met Tyr Gly Glu Tyr Val Lys Asn Phe Asp Arg 
                245                 250                 255     


Ala Val Gly Leu Val Ser Thr Trp Thr Gln Arg Ser Pro Leu Phe Lys 
            260                 265                 270         


Asp Val Val His Ser Ile Gln Lys Gln Glu Val Cys Gly Asn Leu Thr 
        275                 280                 285             


Leu Gln His His Met Leu Glu Pro Val Gln Arg Val Pro Arg Tyr Glu 
    290                 295                 300                 


Leu Leu Leu Lys Asp Tyr Leu Lys Arg Leu Pro Gln Asp Ala Pro Asp 
305                 310                 315                 320 


Arg Lys Asp Ala Glu Arg Ser Leu Glu Leu Ile Ser Thr Ala Ala Asn 
                325                 330                 335     


His Ser Asn Ala Ala Ile Arg Lys Val Glu Lys Met His Lys Leu Leu 
            340                 345                 350         


Glu Val Tyr Glu Gln Leu Gly Gly Glu Glu Asp Ile Val Asn Pro Ala 
        355                 360                 365             


Asn Glu Leu Ile Lys Glu Gly Gln Ile Gln Lys Leu Ser Ala Lys Asn 
    370                 375                 380                 


Gly Thr Pro Gln Asp Arg His Leu Phe Leu Phe Asn Ser Met Ile Leu 
385                 390                 395                 400 


Tyr Cys Val Pro Lys Leu Arg Leu Met Gly Gln Lys Phe Ser Val Arg 
                405                 410                 415     


Glu Lys Met Asp Ile Ser Gly Leu Gln Val Gln Asp Ile Val Lys Pro 
            420                 425                 430         


Asn Thr Ala His Thr Phe Ile Ile Thr Gly Arg Lys Arg Ser Leu Glu 
        435                 440                 445             


Leu Gln Thr Arg Thr Glu Glu Glu Lys Lys Glu Trp Ile Gln Ile Ile 
    450                 455                 460                 


Gln Ala Thr Ile Glu Lys His Lys Gln Asn Ser Glu Thr Phe Lys Ala 
465                 470                 475                 480 


Phe Gly Gly Ala Phe Ser Gln Asp Glu Asp Pro Ser Leu Ser Pro Asp 
                485                 490                 495     


Met Pro Ile Thr Ser Thr Ser Pro Val Glu Pro Val Val Thr Thr Glu 
            500                 505                 510         


Gly Ser Ser Gly Ala Ala Gly Leu Glu Pro Arg Lys Leu Ser Ser Lys 
        515                 520                 525             


Thr Arg Arg Asp Lys Glu Lys Gln Ser Cys Lys Ser Cys Gly Glu Thr 
    530                 535                 540                 


Phe Asn Ser Ile Thr Lys Arg Arg His His Cys Lys Leu Cys Gly Ala 
545                 550                 555                 560 


Val Ile Cys Gly Lys Cys Ser Glu Phe Lys Ala Glu Asn Ser Arg Gln 
                565                 570                 575     


Ser Arg Val Cys Arg Asp Cys Phe Leu Thr Gln Pro Val Ala Pro Glu 
            580                 585                 590         


Ser Thr Glu Thr Pro Thr Ala Asp Pro Gln Pro Ser Leu Leu Cys Gly 
        595                 600                 605             


Pro Leu Arg Leu Ser Glu Ser Gly Glu Thr Trp Ser Glu Val Trp Ala 
    610                 615                 620                 


Ala Ile Pro Met Ser Asp Pro Gln Val Leu His Leu Gln Gly Gly Ser 
625                 630                 635                 640 


Gln Asp Gly Arg Leu Pro Arg Thr Ile Pro Leu Pro Ser Cys Lys Leu 
                645                 650                 655     


Ser Val Pro Asp Pro Glu Glu Arg Leu Asp Ser Gly His Val Trp Lys 
            660                 665                 670         


Leu Gln Trp Ala Lys Gln Ser Trp Tyr Leu Ser Ala Ser Ser Ala Glu 
        675                 680                 685             


Leu Gln Gln Gln Trp Leu Glu Thr Leu Ser Thr Ala Ala His Gly Asp 
    690                 695                 700                 


Thr Ala Gln Asp Ser Pro Gly Ala Leu Gln Leu Gln Val Pro Met Gly 
705                 710                 715                 720 


Ala Ala Ala Pro 
                


<210>  38
<211>  116
<212>  PRT
<213>  homo sapiens

<400>  38

Met Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu 
1               5                   10                  15      


Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu 
            20                  25                  30          


Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val 
        35                  40                  45              


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
    50                  55                  60                  


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser 
65                  70                  75                  80  


Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met 
                85                  90                  95      


Ile Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val 
            100                 105                 110         


Tyr Phe Ser Thr 
        115     


<210>  39
<211>  2527
<212>  PRT
<213>  homo sapiens

<400>  39

Met Ala Ser Gly Ser Cys Gln Gly Cys Glu Glu Asp Glu Glu Thr Leu 
1               5                   10                  15      


Lys Lys Leu Ile Val Arg Leu Asn Asn Val Gln Glu Gly Lys Gln Ile 
            20                  25                  30          


Glu Thr Leu Val Gln Ile Leu Glu Asp Leu Leu Val Phe Thr Tyr Ser 
        35                  40                  45              


Glu His Ala Ser Lys Leu Phe Gln Gly Lys Asn Ile His Val Pro Leu 
    50                  55                  60                  


Leu Ile Val Leu Asp Ser Tyr Met Arg Val Ala Ser Val Gln Gln Val 
65                  70                  75                  80  


Gly Trp Ser Leu Leu Cys Lys Leu Ile Glu Val Cys Pro Gly Thr Met 
                85                  90                  95      


Gln Ser Leu Met Gly Pro Gln Asp Val Gly Asn Asp Trp Glu Val Leu 
            100                 105                 110         


Gly Val His Gln Leu Ile Leu Lys Met Leu Thr Val His Asn Ala Ser 
        115                 120                 125             


Val Asn Leu Ser Val Ile Gly Leu Lys Thr Leu Asp Leu Leu Leu Thr 
    130                 135                 140                 


Ser Gly Lys Ile Thr Leu Leu Ile Leu Asp Glu Glu Ser Asp Ile Phe 
145                 150                 155                 160 


Met Leu Ile Phe Asp Ala Met His Ser Phe Pro Ala Asn Asp Glu Val 
                165                 170                 175     


Gln Lys Leu Gly Cys Lys Ala Leu His Val Leu Phe Glu Arg Val Ser 
            180                 185                 190         


Glu Glu Gln Leu Thr Glu Phe Val Glu Asn Lys Asp Tyr Met Ile Leu 
        195                 200                 205             


Leu Ser Ala Leu Thr Asn Phe Lys Asp Glu Glu Glu Ile Val Leu His 
    210                 215                 220                 


Val Leu His Cys Leu His Ser Leu Ala Ile Pro Cys Asn Asn Val Glu 
225                 230                 235                 240 


Val Leu Met Ser Gly Asn Val Arg Cys Tyr Asn Ile Val Val Glu Ala 
                245                 250                 255     


Met Lys Ala Phe Pro Met Ser Glu Arg Ile Gln Glu Val Ser Cys Cys 
            260                 265                 270         


Leu Leu His Arg Leu Thr Leu Gly Asn Phe Phe Asn Ile Leu Val Leu 
        275                 280                 285             


Asn Glu Val His Glu Phe Val Val Lys Ala Val Gln Gln Tyr Pro Glu 
    290                 295                 300                 


Asn Ala Ala Leu Gln Ile Ser Ala Leu Ser Cys Leu Ala Leu Leu Thr 
305                 310                 315                 320 


Glu Thr Ile Phe Leu Asn Gln Asp Leu Glu Glu Lys Asn Glu Asn Gln 
                325                 330                 335     


Glu Asn Asp Asp Glu Gly Glu Glu Asp Lys Leu Phe Trp Leu Glu Ala 
            340                 345                 350         


Cys Tyr Lys Ala Leu Thr Trp His Arg Lys Asn Lys His Val Gln Glu 
        355                 360                 365             


Ala Ala Cys Trp Ala Leu Asn Asn Leu Leu Met Tyr Gln Asn Ser Leu 
    370                 375                 380                 


His Glu Lys Ile Gly Asp Glu Asp Gly His Phe Pro Ala His Arg Glu 
385                 390                 395                 400 


Val Met Leu Ser Met Leu Met His Ser Ser Ser Lys Glu Val Phe Gln 
                405                 410                 415     


Ala Ser Ala Asn Ala Leu Ser Thr Leu Leu Glu Gln Asn Val Asn Phe 
            420                 425                 430         


Arg Lys Ile Leu Leu Ser Lys Gly Ile His Leu Asn Val Leu Glu Leu 
        435                 440                 445             


Met Gln Lys His Ile His Ser Pro Glu Val Ala Glu Ser Gly Cys Lys 
    450                 455                 460                 


Met Leu Asn His Leu Phe Glu Gly Ser Asn Thr Ser Leu Asp Ile Met 
465                 470                 475                 480 


Ala Ala Val Val Pro Lys Ile Leu Thr Val Met Lys Arg His Glu Thr 
                485                 490                 495     


Ser Leu Pro Val Gln Leu Glu Ala Leu Arg Ala Ile Leu His Phe Ile 
            500                 505                 510         


Val Pro Gly Met Pro Glu Glu Ser Arg Glu Asp Thr Glu Phe His His 
        515                 520                 525             


Lys Leu Asn Met Val Lys Lys Gln Cys Phe Lys Asn Asp Ile His Lys 
    530                 535                 540                 


Leu Val Leu Ala Ala Leu Asn Arg Phe Ile Gly Asn Pro Gly Ile Gln 
545                 550                 555                 560 


Lys Cys Gly Leu Lys Val Ile Ser Ser Ile Val His Phe Pro Asp Ala 
                565                 570                 575     


Leu Glu Met Leu Ser Leu Glu Gly Ala Met Asp Ser Val Leu His Thr 
            580                 585                 590         


Leu Gln Met Tyr Pro Asp Asp Gln Glu Ile Gln Cys Leu Gly Leu Ser 
        595                 600                 605             


Leu Ile Gly Tyr Leu Ile Thr Lys Lys Asn Val Phe Ile Gly Thr Gly 
    610                 615                 620                 


His Leu Leu Ala Lys Ile Leu Val Ser Ser Leu Tyr Arg Phe Lys Asp 
625                 630                 635                 640 


Val Ala Glu Ile Gln Thr Lys Gly Phe Gln Thr Ile Leu Ala Ile Leu 
                645                 650                 655     


Lys Leu Ser Ala Ser Phe Ser Lys Leu Leu Val His His Ser Phe Asp 
            660                 665                 670         


Leu Val Ile Phe His Gln Met Ser Ser Asn Ile Met Glu Gln Lys Asp 
        675                 680                 685             


Gln Gln Phe Leu Asn Leu Cys Cys Lys Cys Phe Ala Lys Val Ala Met 
    690                 695                 700                 


Asp Asp Tyr Leu Lys Asn Val Met Leu Glu Arg Ala Cys Asp Gln Asn 
705                 710                 715                 720 


Asn Ser Ile Met Val Glu Cys Leu Leu Leu Leu Gly Ala Asp Ala Asn 
                725                 730                 735     


Gln Ala Lys Glu Gly Ser Ser Leu Ile Cys Gln Val Cys Glu Lys Glu 
            740                 745                 750         


Ser Ser Pro Lys Leu Val Glu Leu Leu Leu Asn Ser Gly Ser Arg Glu 
        755                 760                 765             


Gln Asp Val Arg Lys Ala Leu Thr Ile Ser Ile Gly Lys Gly Asp Ser 
    770                 775                 780                 


Gln Ile Ile Ser Leu Leu Leu Arg Arg Leu Ala Leu Asp Val Ala Asn 
785                 790                 795                 800 


Asn Ser Ile Cys Leu Gly Gly Phe Cys Ile Gly Lys Val Glu Pro Ser 
                805                 810                 815     


Trp Leu Gly Pro Leu Phe Pro Asp Lys Thr Ser Asn Leu Arg Lys Gln 
            820                 825                 830         


Thr Asn Ile Ala Ser Thr Leu Ala Arg Met Val Ile Arg Tyr Gln Met 
        835                 840                 845             


Lys Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe 
    850                 855                 860                 


Ser Glu Asp Val Leu Ser Lys Phe Asp Glu Trp Thr Phe Ile Pro Asp 
865                 870                 875                 880 


Ser Ser Met Asp Ser Val Phe Ala Gln Ser Asp Asp Leu Asp Ser Glu 
                885                 890                 895     


Gly Ser Glu Gly Ser Phe Leu Val Lys Lys Lys Ser Asn Ser Ile Ser 
            900                 905                 910         


Val Gly Glu Phe Tyr Arg Asp Ala Val Leu Gln Arg Cys Ser Pro Asn 
        915                 920                 925             


Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp 
    930                 935                 940                 


Leu Leu Lys Arg Lys Arg Lys Ile Leu Ser Ser Asp Asp Ser Leu Arg 
945                 950                 955                 960 


Ser Ser Lys Leu Gln Ser His Met Arg His Ser Asp Ser Ile Ser Ser 
                965                 970                 975     


Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp Leu Ser Ala Asn 
            980                 985                 990         


Glu Leu Arg Asp Ile Asp Ala Leu  Ser Gln Lys Cys Cys  Ile Ser Val 
        995                 1000                 1005             


His Leu  Glu His Leu Glu Lys  Leu Glu Leu His Gln  Asn Ala Leu 
    1010                 1015                 1020             


Thr Ser  Phe Pro Gln Gln Leu  Cys Glu Thr Leu Lys  Ser Leu Thr 
    1025                 1030                 1035             


His Leu  Asp Leu His Ser Asn  Lys Phe Thr Ser Phe  Pro Ser Tyr 
    1040                 1045                 1050             


Leu Leu  Lys Met Ser Cys Ile  Ala Asn Leu Asp Val  Ser Arg Asn 
    1055                 1060                 1065             


Asp Ile  Gly Pro Ser Val Val  Leu Asp Pro Thr Val  Lys Cys Pro 
    1070                 1075                 1080             


Thr Leu  Lys Gln Phe Asn Leu  Ser Tyr Asn Gln Leu  Ser Phe Val 
    1085                 1090                 1095             


Pro Glu  Asn Leu Thr Asp Val  Val Glu Lys Leu Glu  Gln Leu Ile 
    1100                 1105                 1110             


Leu Glu  Gly Asn Lys Ile Ser  Gly Ile Cys Ser Pro  Leu Arg Leu 
    1115                 1120                 1125             


Lys Glu  Leu Lys Ile Leu Asn  Leu Ser Lys Asn His  Ile Ser Ser 
    1130                 1135                 1140             


Leu Ser  Glu Asn Phe Leu Glu  Ala Cys Pro Lys Val  Glu Ser Phe 
    1145                 1150                 1155             


Ser Ala  Arg Met Asn Phe Leu  Ala Ala Met Pro Phe  Leu Pro Pro 
    1160                 1165                 1170             


Ser Met  Thr Ile Leu Lys Leu  Ser Gln Asn Lys Phe  Ser Cys Ile 
    1175                 1180                 1185             


Pro Glu  Ala Ile Leu Asn Leu  Pro His Leu Arg Ser  Leu Asp Met 
    1190                 1195                 1200             


Ser Ser  Asn Asp Ile Gln Tyr  Leu Pro Gly Pro Ala  His Trp Lys 
    1205                 1210                 1215             


Ser Leu  Asn Leu Arg Glu Leu  Leu Phe Ser His Asn  Gln Ile Ser 
    1220                 1225                 1230             


Ile Leu  Asp Leu Ser Glu Lys  Ala Tyr Leu Trp Ser  Arg Val Glu 
    1235                 1240                 1245             


Lys Leu  His Leu Ser His Asn  Lys Leu Lys Glu Ile  Pro Pro Glu 
    1250                 1255                 1260             


Ile Gly  Cys Leu Glu Asn Leu  Thr Ser Leu Asp Val  Ser Tyr Asn 
    1265                 1270                 1275             


Leu Glu  Leu Arg Ser Phe Pro  Asn Glu Met Gly Lys  Leu Ser Lys 
    1280                 1285                 1290             


Ile Trp  Asp Leu Pro Leu Asp  Glu Leu His Leu Asn  Phe Asp Phe 
    1295                 1300                 1305             


Lys His  Ile Gly Cys Lys Ala  Lys Asp Ile Ile Arg  Phe Leu Gln 
    1310                 1315                 1320             


Gln Arg  Leu Lys Lys Ala Val  Pro Tyr Asn Arg Met  Lys Leu Met 
    1325                 1330                 1335             


Ile Val  Gly Asn Thr Gly Ser  Gly Lys Thr Thr Leu  Leu Gln Gln 
    1340                 1345                 1350             


Leu Met  Lys Thr Lys Lys Ser  Asp Leu Gly Met Gln  Ser Ala Thr 
    1355                 1360                 1365             


Val Gly  Ile Asp Val Lys Asp  Trp Pro Ile Gln Ile  Arg Asp Lys 
    1370                 1375                 1380             


Arg Lys  Arg Asp Leu Val Leu  Asn Val Trp Asp Phe  Ala Gly Arg 
    1385                 1390                 1395             


Glu Glu  Phe Tyr Ser Thr His  Pro His Phe Met Thr  Gln Arg Ala 
    1400                 1405                 1410             


Leu Tyr  Leu Ala Val Tyr Asp  Leu Ser Lys Gly Gln  Ala Glu Val 
    1415                 1420                 1425             


Asp Ala  Met Lys Pro Trp Leu  Phe Asn Ile Lys Ala  Arg Ala Ser 
    1430                 1435                 1440             


Ser Ser  Pro Val Ile Leu Val  Gly Thr His Leu Asp  Val Ser Asp 
    1445                 1450                 1455             


Glu Lys  Gln Arg Lys Ala Cys  Met Ser Lys Ile Thr  Lys Glu Leu 
    1460                 1465                 1470             


Leu Asn  Lys Arg Gly Phe Pro  Ala Ile Arg Asp Tyr  His Phe Val 
    1475                 1480                 1485             


Asn Ala  Thr Glu Glu Ser Asp  Ala Leu Ala Lys Leu  Arg Lys Thr 
    1490                 1495                 1500             


Ile Ile  Asn Glu Ser Leu Asn  Phe Lys Ile Arg Asp  Gln Leu Val 
    1505                 1510                 1515             


Val Gly  Gln Leu Ile Pro Asp  Cys Tyr Val Glu Leu  Glu Lys Ile 
    1520                 1525                 1530             


Ile Leu  Ser Glu Arg Lys Asn  Val Pro Ile Glu Phe  Pro Val Ile 
    1535                 1540                 1545             


Asp Arg  Lys Arg Leu Leu Gln  Leu Val Arg Glu Asn  Gln Leu Gln 
    1550                 1555                 1560             


Leu Asp  Glu Asn Glu Leu Pro  His Ala Val His Phe  Leu Asn Glu 
    1565                 1570                 1575             


Ser Gly  Val Leu Leu His Phe  Gln Asp Pro Ala Leu  Gln Leu Ser 
    1580                 1585                 1590             


Asp Leu  Tyr Phe Val Glu Pro  Lys Trp Leu Cys Lys  Ile Met Ala 
    1595                 1600                 1605             


Gln Ile  Leu Thr Val Lys Val  Glu Gly Cys Pro Lys  His Pro Lys 
    1610                 1615                 1620             


Gly Ile  Ile Ser Arg Arg Asp  Val Glu Lys Phe Leu  Ser Lys Lys 
    1625                 1630                 1635             


Arg Lys  Phe Pro Lys Asn Tyr  Met Ser Gln Tyr Phe  Lys Leu Leu 
    1640                 1645                 1650             


Glu Lys  Phe Gln Ile Ala Leu  Pro Ile Gly Glu Glu  Tyr Leu Leu 
    1655                 1660                 1665             


Val Pro  Ser Ser Leu Ser Asp  His Arg Pro Val Ile  Glu Leu Pro 
    1670                 1675                 1680             


His Cys  Glu Asn Ser Glu Ile  Ile Ile Arg Leu Tyr  Glu Met Pro 
    1685                 1690                 1695             


Tyr Phe  Pro Met Gly Phe Trp  Ser Arg Leu Ile Asn  Arg Leu Leu 
    1700                 1705                 1710             


Glu Ile  Ser Pro Tyr Met Leu  Ser Gly Arg Glu Arg  Ala Leu Arg 
    1715                 1720                 1725             


Pro Asn  Arg Met Tyr Trp Arg  Gln Gly Ile Tyr Leu  Asn Trp Ser 
    1730                 1735                 1740             


Pro Glu  Ala Tyr Cys Leu Val  Gly Ser Glu Val Leu  Asp Asn His 
    1745                 1750                 1755             


Pro Glu  Ser Phe Leu Lys Ile  Thr Val Pro Ser Cys  Arg Lys Gly 
    1760                 1765                 1770             


Cys Ile  Leu Leu Gly Gln Val  Val Asp His Ile Asp  Ser Leu Met 
    1775                 1780                 1785             


Glu Glu  Trp Phe Pro Gly Leu  Leu Glu Ile Asp Ile  Cys Gly Glu 
    1790                 1795                 1800             


Gly Glu  Thr Leu Leu Lys Lys  Trp Ala Leu Tyr Ser  Phe Asn Asp 
    1805                 1810                 1815             


Gly Glu  Glu His Gln Lys Ile  Leu Leu Asp Asp Leu  Met Lys Lys 
    1820                 1825                 1830             


Ala Glu  Glu Gly Asp Leu Leu  Val Asn Pro Asp Gln  Pro Arg Leu 
    1835                 1840                 1845             


Thr Ile  Pro Ile Ser Gln Ile  Ala Pro Asp Leu Ile  Leu Ala Asp 
    1850                 1855                 1860             


Leu Pro  Arg Asn Ile Met Leu  Asn Asn Asp Glu Leu  Glu Phe Glu 
    1865                 1870                 1875             


Gln Ala  Pro Glu Phe Leu Leu  Gly Asp Gly Ser Phe  Gly Ser Val 
    1880                 1885                 1890             


Tyr Arg  Ala Ala Tyr Glu Gly  Glu Glu Val Ala Val  Lys Ile Phe 
    1895                 1900                 1905             


Asn Lys  His Thr Ser Leu Arg  Leu Leu Arg Gln Glu  Leu Val Val 
    1910                 1915                 1920             


Leu Cys  His Leu His His Pro  Ser Leu Ile Ser Leu  Leu Ala Ala 
    1925                 1930                 1935             


Gly Ile  Arg Pro Arg Met Leu  Val Met Glu Leu Ala  Ser Lys Gly 
    1940                 1945                 1950             


Ser Leu  Asp Arg Leu Leu Gln  Gln Asp Lys Ala Ser  Leu Thr Arg 
    1955                 1960                 1965             


Thr Leu  Gln His Arg Ile Ala  Leu His Val Ala Asp  Gly Leu Arg 
    1970                 1975                 1980             


Tyr Leu  His Ser Ala Met Ile  Ile Tyr Arg Asp Leu  Lys Pro His 
    1985                 1990                 1995             


Asn Val  Leu Leu Phe Thr Leu  Tyr Pro Asn Ala Ala  Ile Ile Ala 
    2000                 2005                 2010             


Lys Ile  Ala Asp Tyr Gly Ile  Ala Gln Tyr Cys Cys  Arg Met Gly 
    2015                 2020                 2025             


Ile Lys  Thr Ser Glu Gly Thr  Pro Gly Phe Arg Ala  Pro Glu Val 
    2030                 2035                 2040             


Ala Arg  Gly Asn Val Ile Tyr  Asn Gln Gln Ala Asp  Val Tyr Ser 
    2045                 2050                 2055             


Phe Gly  Leu Leu Leu Tyr Asp  Ile Leu Thr Thr Gly  Gly Arg Ile 
    2060                 2065                 2070             


Val Glu  Gly Leu Lys Phe Pro  Asn Glu Phe Asp Glu  Leu Glu Ile 
    2075                 2080                 2085             


Gln Gly  Lys Leu Pro Asp Pro  Val Lys Glu Tyr Gly  Cys Ala Pro 
    2090                 2095                 2100             


Trp Pro  Met Val Glu Lys Leu  Ile Lys Gln Cys Leu  Lys Glu Asn 
    2105                 2110                 2115             


Pro Gln  Glu Arg Pro Thr Ser  Ala Gln Val Phe Asp  Ile Leu Asn 
    2120                 2125                 2130             


Ser Ala  Glu Leu Val Cys Leu  Thr Arg Arg Ile Leu  Leu Pro Lys 
    2135                 2140                 2145             


Asn Val  Ile Val Glu Cys Met  Val Ala Thr His His  Asn Ser Arg 
    2150                 2155                 2160             


Asn Ala  Ser Ile Trp Leu Gly  Cys Gly His Thr Asp  Arg Gly Gln 
    2165                 2170                 2175             


Leu Ser  Phe Leu Asp Leu Asn  Thr Glu Gly Tyr Thr  Ser Glu Glu 
    2180                 2185                 2190             


Val Ala  Asp Ser Arg Ile Leu  Cys Leu Ala Leu Val  His Leu Pro 
    2195                 2200                 2205             


Val Glu  Lys Glu Ser Trp Ile  Val Ser Gly Thr Gln  Ser Gly Thr 
    2210                 2215                 2220             


Leu Leu  Val Ile Asn Thr Glu  Asp Gly Lys Lys Arg  His Thr Leu 
    2225                 2230                 2235             


Glu Lys  Met Thr Asp Ser Val  Thr Cys Leu Tyr Cys  Asn Ser Phe 
    2240                 2245                 2250             


Ser Lys  Gln Ser Lys Gln Lys  Asn Phe Leu Leu Val  Gly Thr Ala 
    2255                 2260                 2265             


Asp Gly  Lys Leu Ala Ile Phe  Glu Asp Lys Thr Val  Lys Leu Lys 
    2270                 2275                 2280             


Gly Ala  Ala Pro Leu Lys Ile  Leu Asn Ile Gly Asn  Val Ser Thr 
    2285                 2290                 2295             


Pro Leu  Met Cys Leu Ser Glu  Ser Thr Asn Ser Thr  Glu Arg Asn 
    2300                 2305                 2310             


Val Met  Trp Gly Gly Cys Gly  Thr Lys Ile Phe Ser  Phe Ser Asn 
    2315                 2320                 2325             


Asp Phe  Thr Ile Gln Lys Leu  Ile Glu Thr Arg Thr  Ser Gln Leu 
    2330                 2335                 2340             


Phe Ser  Tyr Ala Ala Phe Ser  Asp Ser Asn Ile Ile  Thr Val Val 
    2345                 2350                 2355             


Val Asp  Thr Ala Leu Tyr Ile  Ala Lys Gln Asn Ser  Pro Val Val 
    2360                 2365                 2370             


Glu Val  Trp Asp Lys Lys Thr  Glu Lys Leu Cys Gly  Leu Ile Asp 
    2375                 2380                 2385             


Cys Val  His Phe Leu Arg Glu  Val Met Val Lys Glu  Asn Lys Glu 
    2390                 2395                 2400             


Ser Lys  His Lys Met Ser Tyr  Ser Gly Arg Val Lys  Thr Leu Cys 
    2405                 2410                 2415             


Leu Gln  Lys Asn Thr Ala Leu  Trp Ile Gly Thr Gly  Gly Gly His 
    2420                 2425                 2430             


Ile Leu  Leu Leu Asp Leu Ser  Thr Arg Arg Leu Ile  Arg Val Ile 
    2435                 2440                 2445             


Tyr Asn  Phe Cys Asn Ser Val  Arg Val Met Met Thr  Ala Gln Leu 
    2450                 2455                 2460             


Gly Ser  Leu Lys Asn Val Met  Leu Val Leu Gly Tyr  Asn Arg Lys 
    2465                 2470                 2475             


Asn Thr  Glu Gly Thr Gln Lys  Gln Lys Glu Ile Gln  Ser Cys Leu 
    2480                 2485                 2490             


Thr Val  Trp Asp Ile Asn Leu  Pro His Glu Val Gln  Asn Leu Glu 
    2495                 2500                 2505             


Lys His  Ile Glu Val Arg Lys  Glu Leu Ala Glu Lys  Met Arg Arg 
    2510                 2515                 2520             


Thr Ser  Val Glu 
    2525         


<210>  40
<211>  382
<212>  PRT
<213>  homo sapiens

<400>  40

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro 
            260                 265                 270         


Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr 
        275                 280                 285             


Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln 
    290                 295                 300                 


Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro 
305                 310                 315                 320 


Gly Ser Ile Leu Cys Met Thr Pro Ala Thr Ser Val Val Pro Met Val 
                325                 330                 335     


His Gly Ala Thr Pro Ala Thr Val Ser Ala Ala Thr Thr Ser Ala Thr 
            340                 345                 350         


Ser Val Pro Phe Ala Ala Thr Ala Thr Ala Asn Gln Ile Pro Ile Ile 
        355                 360                 365             


Ser Ala Glu His Leu Thr Ser His Lys Tyr Val Thr Gln Met 
    370                 375                 380         


<210>  41
<211>  370
<212>  PRT
<213>  homo sapiens

<400>  41

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro 
            260                 265                 270         


Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr 
        275                 280                 285             


Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln 
    290                 295                 300                 


Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro 
305                 310                 315                 320 


Val Pro Met Val His Gly Ala Thr Pro Ala Thr Val Ser Ala Ala Thr 
                325                 330                 335     


Thr Ser Ala Thr Ser Val Pro Phe Ala Ala Thr Ala Thr Ala Asn Gln 
            340                 345                 350         


Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr Val Thr 
        355                 360                 365             


Gln Met 
    370 


<210>  42
<211>  388
<212>  PRT
<213>  homo sapiens

<400>  42

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Thr Gln Ser 
            260                 265                 270         


Ala Val Lys Ser Leu Lys Arg Pro Leu Glu Ala Thr Phe Asp Leu Gly 
        275                 280                 285             


Ile Pro Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu 
    290                 295                 300                 


Lys Thr Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr 
305                 310                 315                 320 


Gln Gln Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu 
                325                 330                 335     


Pro Pro Val Pro Met Val His Gly Ala Thr Pro Ala Thr Val Ser Ala 
            340                 345                 350         


Ala Thr Thr Ser Ala Thr Ser Val Pro Phe Ala Ala Thr Ala Thr Ala 
        355                 360                 365             


Asn Gln Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr 
    370                 375                 380                 


Val Thr Gln Met 
385             


<210>  43
<211>  302
<212>  PRT
<213>  homo sapiens

<400>  43

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Val Cys Arg Glu Tyr Gln Arg Gly Asn Cys Asn Arg Gly 
        115                 120                 125             


Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile Asp 
    130                 135                 140                 


Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly Arg 
145                 150                 155                 160 


Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu Gln 
                165                 170                 175     


Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln Ala Ala Ala Ala 
            180                 185                 190         


Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro Gln Ala Val Leu 
        195                 200                 205             


Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr Asn Gly Ala Thr 
    210                 215                 220                 


Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln Ala Leu Ala Asn 
225                 230                 235                 240 


Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro Val Pro Met Val 
                245                 250                 255     


His Gly Ala Thr Pro Ala Thr Val Ser Ala Ala Thr Thr Ser Ala Thr 
            260                 265                 270         


Ser Val Pro Phe Ala Ala Thr Ala Thr Ala Asn Gln Ile Pro Ile Ile 
        275                 280                 285             


Ser Ala Glu His Leu Thr Ser His Lys Tyr Val Thr Gln Met 
    290                 295                 300         


<210>  44
<211>  314
<212>  PRT
<213>  homo sapiens

<400>  44

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Val Cys Arg Glu Tyr Gln Arg Gly Asn Cys Asn Arg Gly 
        115                 120                 125             


Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile Asp 
    130                 135                 140                 


Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly Arg 
145                 150                 155                 160 


Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu Gln 
                165                 170                 175     


Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln Ala Ala Ala Ala 
            180                 185                 190         


Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro Gln Ala Val Leu 
        195                 200                 205             


Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr Asn Gly Ala Thr 
    210                 215                 220                 


Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln Ala Leu Ala Asn 
225                 230                 235                 240 


Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro Gly Ser Ile Leu 
                245                 250                 255     


Cys Met Thr Pro Ala Thr Ser Val Val Pro Met Val His Gly Ala Thr 
            260                 265                 270         


Pro Ala Thr Val Ser Ala Ala Thr Thr Ser Ala Thr Ser Val Pro Phe 
        275                 280                 285             


Ala Ala Thr Ala Thr Ala Asn Gln Ile Pro Ile Ile Ser Ala Glu His 
    290                 295                 300                 


Leu Thr Ser His Lys Tyr Val Thr Gln Met 
305                 310                 


<210>  45
<211>  340
<212>  PRT
<213>  homo sapiens

<400>  45

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Phe Pro Trp 
            260                 265                 270         


Cys Thr Val Leu Arg Gln Pro Leu Cys Pro Gln Gln Gln His Leu Pro 
        275                 280                 285             


Gln Val Phe Pro Ser Leu Gln Gln Pro Gln Pro Thr Ser Pro Ile Leu 
    290                 295                 300                 


Asp Ala Ser Thr Leu Leu Gly Ala Thr Ser Cys Pro Ala Ala Ala Gly 
305                 310                 315                 320 


Lys Met Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr 
                325                 330                 335     


Val Thr Gln Met 
            340 


<210>  46
<211>  342
<212>  PRT
<213>  homo sapiens

<400>  46

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro 
            260                 265                 270         


Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr 
        275                 280                 285             


Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln 
    290                 295                 300                 


Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro 
305                 310                 315                 320 


Gly Ser Ile Leu Cys Met Thr Pro Ala Thr Ser Val Asp Thr His Asn 
                325                 330                 335     


Ile Cys Arg Thr Ser Asp 
            340         


<210>  47
<211>  839
<212>  PRT
<213>  homo sapiens

<400>  47

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe 
705                 710                 715                 720 


Cys Ile Trp Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp 
                725                 730                 735     


Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp 
            740                 745                 750         


Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys 
        755                 760                 765             


Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr 
    770                 775                 780                 


Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr 
785                 790                 795                 800 


Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn 
                805                 810                 815     


Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala Thr Pro 
            820                 825                 830         


Ile Tyr Leu Asp Ile Leu Gly 
        835                 


<210>  48
<211>  825
<212>  PRT
<213>  homo sapiens

<400>  48

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile 
705                 710                 715                 720 


Arg Trp Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu 
                725                 730                 735     


Ser Asp Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr 
            740                 745                 750         


Gly Lys Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys 
        755                 760                 765             


Ile Thr Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu 
    770                 775                 780                 


Val Tyr Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg 
785                 790                 795                 800 


Leu Asn Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala 
                805                 810                 815     


Thr Pro Ile Tyr Leu Asp Ile Leu Gly 
            820                 825 


<210>  49
<211>  612
<212>  PRT
<213>  homo sapiens

<400>  49

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Trp Val Phe Ser Asn Ile Asp Asn His Gly Ile Leu Asn Leu Lys Asp 
    530                 535                 540                 


Asn Arg Asp His Leu Val Pro Ser Thr His Tyr Ile Tyr Glu Glu Pro 
545                 550                 555                 560 


Glu Val Gln Ser Gly Glu Val Ser Tyr Pro Arg Ser His Gly Phe Arg 
                565                 570                 575     


Glu Ile Met Leu Asn Pro Ile Ser Leu Pro Gly His Ser Lys Pro Leu 
            580                 585                 590         


Asn His Gly Ile Tyr Val Glu Asp Val Asn Val Tyr Phe Ser Lys Gly 
        595                 600                 605             


Arg His Gly Phe 
    610         


<210>  50
<211>  817
<212>  PRT
<213>  homo sapiens

<400>  50

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Val Asp Glu Val Ser Pro Thr Pro Pro Ile Thr Val Thr His Lys 
                405                 410                 415     


Pro Glu Glu Asp Thr Phe Gly Val Ser Ile Ala Val Gly Leu Ala Ala 
            420                 425                 430         


Phe Ala Cys Val Leu Leu Val Val Leu Phe Val Met Ile Asn Lys Tyr 
        435                 440                 445             


Gly Arg Arg Ser Lys Phe Gly Met Lys Gly Pro Val Ala Val Ile Ser 
    450                 455                 460                 


Gly Glu Glu Asp Ser Ala Ser Pro Leu His His Ile Asn His Gly Ile 
465                 470                 475                 480 


Thr Thr Pro Ser Ser Leu Asp Ala Gly Pro Asp Thr Val Val Ile Gly 
                485                 490                 495     


Met Thr Arg Ile Pro Val Ile Glu Asn Pro Gln Tyr Phe Arg Gln Gly 
            500                 505                 510         


His Asn Cys His Lys Pro Asp Thr Tyr Val Gln His Ile Lys Arg Arg 
        515                 520                 525             


Asp Ile Val Leu Lys Arg Glu Leu Gly Glu Gly Ala Phe Gly Lys Val 
    530                 535                 540                 


Phe Leu Ala Glu Cys Tyr Asn Leu Ser Pro Thr Lys Asp Lys Met Leu 
545                 550                 555                 560 


Val Ala Val Lys Ala Leu Lys Asp Pro Thr Leu Ala Ala Arg Lys Asp 
                565                 570                 575     


Phe Gln Arg Glu Ala Glu Leu Leu Thr Asn Leu Gln His Glu His Ile 
            580                 585                 590         


Val Lys Phe Tyr Gly Val Cys Gly Asp Gly Asp Pro Leu Ile Met Val 
        595                 600                 605             


Phe Glu Tyr Met Lys His Gly Asp Leu Asn Lys Phe Leu Arg Ala His 
    610                 615                 620                 


Gly Pro Asp Ala Met Ile Leu Val Asp Gly Gln Pro Arg Gln Ala Lys 
625                 630                 635                 640 


Gly Glu Leu Gly Leu Ser Gln Met Leu His Ile Ala Ser Gln Ile Ala 
                645                 650                 655     


Ser Gly Met Val Tyr Leu Ala Ser Gln His Phe Val His Arg Asp Leu 
            660                 665                 670         


Ala Thr Arg Asn Cys Leu Val Gly Ala Asn Leu Leu Val Lys Ile Gly 
        675                 680                 685             


Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr Asp Tyr Tyr Arg Val 
    690                 695                 700                 


Gly Gly His Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile 
705                 710                 715                 720 


Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val 
                725                 730                 735     


Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Phe Gln Leu 
            740                 745                 750         


Ser Asn Thr Glu Val Ile Glu Cys Ile Thr Gln Gly Arg Val Leu Glu 
        755                 760                 765             


Arg Pro Arg Val Cys Pro Lys Glu Val Tyr Asp Val Met Leu Gly Cys 
    770                 775                 780                 


Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn Ile Lys Glu Ile Tyr Lys 
785                 790                 795                 800 


Ile Leu His Ala Leu Gly Lys Ala Thr Pro Ile Tyr Leu Asp Ile Leu 
                805                 810                 815     


Gly 
    


<210>  51
<211>  218
<212>  PRT
<213>  homo sapiens

<400>  51

Met Ala Ser Arg Gly Gly Gly Arg Gly Arg Gly Arg Gly Gln Leu Thr 
1               5                   10                  15      


Phe Asn Val Glu Ala Val Gly Ile Gly Lys Gly Asp Ala Leu Pro Pro 
            20                  25                  30          


Pro Thr Leu Gln Pro Ser Pro Leu Phe Pro Pro Leu Glu Phe Arg Pro 
        35                  40                  45              


Val Pro Leu Pro Ser Gly Glu Glu Gly Glu Tyr Val Leu Ala Leu Lys 
    50                  55                  60                  


Gln Glu Leu Arg Gly Ala Met Arg Gln Leu Pro Tyr Phe Ile Arg Pro 
65                  70                  75                  80  


Ala Val Pro Lys Arg Asp Val Glu Arg Tyr Ser Asp Lys Tyr Gln Met 
                85                  90                  95      


Ser Gly Pro Ile Asp Asn Ala Ile Asp Trp Asn Pro Asp Trp Arg Arg 
            100                 105                 110         


Leu Pro Arg Glu Leu Lys Ile Arg Val Arg Lys Leu Gln Lys Glu Arg 
        115                 120                 125             


Ile Thr Ile Leu Leu Pro Lys Arg Pro Pro Lys Thr Thr Glu Asp Lys 
    130                 135                 140                 


Glu Glu Thr Ile Gln Lys Leu Glu Thr Leu Glu Lys Lys Glu Glu Glu 
145                 150                 155                 160 


Val Thr Ser Glu Glu Asp Glu Glu Lys Glu Glu Glu Glu Glu Lys Glu 
                165                 170                 175     


Glu Glu Glu Glu Glu Glu Tyr Asp Glu Glu Glu His Glu Glu Glu Thr 
            180                 185                 190         


Asp Tyr Ile Met Ser Tyr Phe Asp Asn Gly Glu Asp Phe Gly Gly Asp 
        195                 200                 205             


Ser Asp Asp Asn Met Asp Glu Ala Ile Tyr 
    210                 215             


<210>  52
<211>  190
<212>  PRT
<213>  homo sapiens

<400>  52

Met Ala Thr His His Thr Leu Trp Met Gly Leu Ala Leu Leu Gly Val 
1               5                   10                  15      


Leu Gly Asp Leu Gln Ala Ala Pro Glu Ala Gln Val Ser Val Gln Pro 
            20                  25                  30          


Asn Phe Gln Gln Asp Lys Phe Leu Gly Arg Trp Phe Ser Ala Gly Leu 
        35                  40                  45              


Ala Ser Asn Ser Ser Trp Leu Arg Glu Lys Lys Ala Ala Leu Ser Met 
    50                  55                  60                  


Cys Lys Ser Val Val Ala Pro Ala Thr Asp Gly Gly Leu Asn Leu Thr 
65                  70                  75                  80  


Ser Thr Phe Leu Arg Lys Asn Gln Cys Glu Thr Arg Thr Met Leu Leu 
                85                  90                  95      


Gln Pro Ala Gly Ser Leu Gly Ser Tyr Ser Tyr Arg Ser Pro His Trp 
            100                 105                 110         


Gly Ser Thr Tyr Ser Val Ser Val Val Glu Thr Asp Tyr Asp Gln Tyr 
        115                 120                 125             


Ala Leu Leu Tyr Ser Gln Gly Ser Lys Gly Pro Gly Glu Asp Phe Arg 
    130                 135                 140                 


Met Ala Thr Leu Tyr Ser Arg Thr Gln Thr Pro Arg Ala Glu Leu Lys 
145                 150                 155                 160 


Glu Lys Phe Thr Ala Phe Cys Lys Ala Gln Gly Phe Thr Glu Asp Thr 
                165                 170                 175     


Ile Val Phe Leu Pro Gln Thr Asp Lys Cys Met Thr Glu Gln 
            180                 185                 190 


<210>  53
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Val Ile Arg Val Tyr Ile Ala Ser Ser Ser Gly Ser Thr Ala Ile 
1               5                   10                  15      


Lys Lys Lys Gln Gln Asp Val Leu Gly Phe Leu Glu Ala Asn Lys Ile 
            20                  25                  30          


Gly Phe Glu Glu Lys Asp Ile Ala Ala Asn Glu Glu Asn Arg Lys Trp 
        35                  40                  45              


Met Arg Glu Asn Val Pro Glu Asn Ser Arg Pro Ala Thr Gly Tyr Pro 
    50                  55                  60                  


Leu Pro Pro Gln Ile Phe Asn Glu Ser Gln Tyr Arg Gly Asp Tyr Asp 
65                  70                  75                  80  


Ala Phe Phe Glu Ala Arg Glu Asn Asn Ala Val Tyr Ala Phe Leu Gly 
                85                  90                  95      


Leu Thr Ala Pro Pro Gly Ser Lys Glu Ala Glu Val Gln Ala Lys Gln 
            100                 105                 110         


Gln Ala 
        


<210>  54
<211>  526
<212>  PRT
<213>  homo sapiens

<400>  54

Met Asp Val Arg Phe Tyr Pro Pro Pro Ala Gln Pro Ala Ala Ala Pro 
1               5                   10                  15      


Asp Ala Pro Cys Leu Gly Pro Ser Pro Cys Leu Asp Pro Tyr Tyr Cys 
            20                  25                  30          


Asn Lys Phe Asp Gly Glu Asn Met Tyr Met Ser Met Thr Glu Pro Ser 
        35                  40                  45              


Gln Asp Tyr Val Pro Ala Ser Gln Ser Tyr Pro Gly Pro Ser Leu Glu 
    50                  55                  60                  


Ser Glu Asp Phe Asn Ile Pro Pro Ile Thr Pro Pro Ser Leu Pro Asp 
65                  70                  75                  80  


His Ser Leu Val His Leu Asn Glu Val Glu Ser Gly Tyr His Ser Leu 
                85                  90                  95      


Cys His Pro Met Asn His Asn Gly Leu Leu Pro Phe His Pro Gln Asn 
            100                 105                 110         


Met Asp Leu Pro Glu Ile Thr Val Ser Asn Met Leu Gly Gln Asp Gly 
        115                 120                 125             


Thr Leu Leu Ser Asn Ser Ile Ser Val Met Pro Asp Ile Arg Asn Pro 
    130                 135                 140                 


Glu Gly Thr Gln Tyr Ser Ser His Pro Gln Met Ala Ala Met Arg Pro 
145                 150                 155                 160 


Arg Gly Gln Pro Ala Asp Ile Arg Gln Gln Pro Gly Met Met Pro His 
                165                 170                 175     


Gly Gln Leu Thr Thr Ile Asn Gln Ser Gln Leu Ser Ala Gln Leu Gly 
            180                 185                 190         


Leu Asn Met Gly Gly Ser Asn Val Pro His Asn Ser Pro Ser Pro Pro 
        195                 200                 205             


Gly Ser Lys Ser Ala Thr Pro Ser Pro Ser Ser Ser Val His Glu Asp 
    210                 215                 220                 


Glu Gly Asp Asp Thr Ser Lys Ile Asn Gly Gly Glu Lys Arg Pro Ala 
225                 230                 235                 240 


Ser Asp Met Gly Lys Lys Pro Lys Thr Pro Lys Lys Lys Lys Lys Lys 
                245                 250                 255     


Asp Pro Asn Glu Pro Gln Lys Pro Val Ser Ala Tyr Ala Leu Phe Phe 
            260                 265                 270         


Arg Asp Thr Gln Ala Ala Ile Lys Gly Gln Asn Pro Asn Ala Thr Phe 
        275                 280                 285             


Gly Glu Val Ser Lys Ile Val Ala Ser Met Trp Asp Gly Leu Gly Glu 
    290                 295                 300                 


Glu Gln Lys Gln Val Tyr Lys Lys Lys Thr Glu Ala Ala Lys Lys Glu 
305                 310                 315                 320 


Tyr Leu Lys Gln Leu Ala Ala Tyr Arg Ala Ser Leu Val Ser Lys Ser 
                325                 330                 335     


Tyr Ser Glu Pro Val Asp Val Lys Thr Ser Gln Pro Pro Gln Leu Ile 
            340                 345                 350         


Asn Ser Lys Pro Ser Val Phe His Gly Pro Ser Gln Ala His Ser Ala 
        355                 360                 365             


Leu Tyr Leu Ser Ser His Tyr His Gln Gln Pro Gly Met Asn Pro His 
    370                 375                 380                 


Leu Thr Ala Met His Pro Ser Leu Pro Arg Asn Ile Ala Pro Lys Pro 
385                 390                 395                 400 


Asn Asn Gln Met Pro Val Thr Val Ser Ile Ala Asn Met Ala Val Ser 
                405                 410                 415     


Pro Pro Pro Pro Leu Gln Ile Ser Pro Pro Leu His Gln His Leu Asn 
            420                 425                 430         


Met Gln Gln His Gln Pro Leu Thr Met Gln Gln Pro Leu Gly Asn Gln 
        435                 440                 445             


Leu Pro Met Gln Val Gln Ser Ala Leu His Ser Pro Thr Met Gln Gln 
    450                 455                 460                 


Gly Phe Thr Leu Gln Pro Asp Tyr Gln Thr Ile Ile Asn Pro Thr Ser 
465                 470                 475                 480 


Thr Ala Ala Gln Val Val Thr Gln Ala Met Glu Tyr Val Arg Ser Gly 
                485                 490                 495     


Cys Arg Asn Pro Pro Pro Gln Pro Val Asp Trp Asn Asn Asp Tyr Cys 
            500                 505                 510         


Ser Ser Gly Gly Met Gln Arg Asp Lys Ala Leu Tyr Leu Thr 
        515                 520                 525     


