                         SEQUENCE LISTING

<110>  Shen, Che-Kun James
       Shyu, Yu-Chiau
 
<120>  EKLF K74R KNOCK-IN NON-HUMAN ANIMAL

<130>  MYHO-001/01WO

<150>  62/039,899
<151>  2014-09-01

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  376
<212>  PRT
<213>  Mus musculus

<400>  1

Met Arg Gln Lys Arg Glu Arg Arg Pro Glu Val Gln Gly Gly His Gln 
1               5                   10                  15      


Pro Ala Met Ala Ser Ala Glu Thr Val Leu Pro Ser Ile Ser Thr Leu 
            20                  25                  30          


Thr Thr Leu Gly Gln Phe Leu Asp Thr Gln Glu Asp Phe Leu Lys Trp 
        35                  40                  45              


Trp Arg Ser Glu Glu Thr Gln Asp Leu Gly Pro Gly Pro Pro Asn Pro 
    50                  55                  60                  


Thr Gly Pro Ser His His Val Ser Leu Lys Ser Glu Asp Pro Ser Gly 
65                  70                  75                  80  


Glu Asp Asp Glu Arg Asp Val Thr Cys Ala Trp Asp Pro Asp Leu Phe 
                85                  90                  95      


Leu Thr Asn Phe Pro Gly Ser Glu Ser Pro Gly Thr Ser Arg Thr Cys 
            100                 105                 110         


Ala Leu Ala Pro Ser Val Gly Pro Val Ala Gln Phe Glu Pro Pro Glu 
        115                 120                 125             


Ser Leu Gly Ala Tyr Ala Gly Gly Pro Gly Leu Val Thr Gly Pro Leu 
    130                 135                 140                 


Gly Ser Glu Glu His Thr Ser Trp Ala His Pro Thr Pro Arg Pro Pro 
145                 150                 155                 160 


Ala Pro Glu Pro Phe Val Ala Pro Ala Leu Ala Pro Gly Leu Ala Pro 
                165                 170                 175     


Lys Ala Gln Pro Ser Tyr Ser Asp Ser Arg Ala Gly Ser Val Gly Gly 
            180                 185                 190         


Phe Phe Pro Arg Ala Gly Leu Ala Val Pro Ala Ala Pro Gly Ala Pro 
        195                 200                 205             


Tyr Gly Leu Leu Ser Gly Tyr Pro Ala Leu Tyr Pro Ala Pro Gln Tyr 
    210                 215                 220                 


Gln Gly His Phe Gln Leu Phe Arg Gly Leu Ala Ala Pro Ser Ala Gly 
225                 230                 235                 240 


Pro Thr Ala Pro Pro Ser Phe Leu Asn Cys Leu Gly Pro Gly Thr Val 
                245                 250                 255     


Ala Thr Glu Leu Gly Ala Thr Ala Ile Ala Gly Asp Ala Gly Leu Ser 
            260                 265                 270         


Pro Gly Thr Ala Pro Pro Lys Arg Ser Arg Arg Thr Leu Ala Pro Lys 
        275                 280                 285             


Arg Gln Ala Ala His Thr Cys Gly His Glu Gly Cys Gly Lys Ser Tyr 
    290                 295                 300                 


Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu 
305                 310                 315                 320 


Lys Pro Tyr Ala Cys Ser Trp Asp Gly Cys Asp Trp Arg Phe Ala Arg 
                325                 330                 335     


Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly His Arg Pro 
            340                 345                 350         


Phe Cys Cys Gly Leu Cys Pro Arg Ala Phe Ser Arg Ser Asp His Leu 
        355                 360                 365             


Ala Leu His Met Lys Arg His Leu 
    370                 375     


<210>  2
<211>  376
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Arg Gln Lys Arg Glu Arg Arg Pro Glu Ala Gln Gly Gly Gln Gln 
1               5                   10                  15      


Pro Val Met Ala Ser Ala Glu Thr Val Leu Pro Ser Ile Ser Thr Leu 
            20                  25                  30          


Thr Thr Leu Gly Gln Phe Leu Asp Thr Gln Glu Asp Phe Leu Lys Trp 
        35                  40                  45              


Trp Arg Ser Glu Glu Thr Gln Asp Leu Gly Pro Gly Pro Pro Asn Pro 
    50                  55                  60                  


Thr Glu Pro Ser Phe His Val Ser Leu Lys Ser Glu Asp Pro Pro Gly 
65                  70                  75                  80  


Glu Asp Asp Glu Arg Asp Val Thr Cys Ala Trp Asp Pro Asp Leu Phe 
                85                  90                  95      


Leu Thr Asn Phe Ser Gly Pro Glu Pro Pro Ser Thr Pro Arg Thr Cys 
            100                 105                 110         


Ala Leu Ala Pro Ser Gly Gly Pro Val Ala Gln Phe Ala Pro Pro Glu 
        115                 120                 125             


Ser Leu Ser Ala Tyr Ala Gly Gly Pro Gly Leu Val Thr Gly Pro Leu 
    130                 135                 140                 


Gly Ser Glu Glu His Ala Gly Trp Ala His Pro Thr Pro Arg Pro Pro 
145                 150                 155                 160 


Thr Pro Glu Pro Phe Val Ala Pro Val Leu Ala Pro Gly Leu Ala Pro 
                165                 170                 175     


Lys Ala Gln Pro Ala Phe Ser Glu Ser Arg Ala Val Ser Ala Gly Gly 
            180                 185                 190         


Phe Phe Pro Arg Ala Gly Leu Ala Val Pro Ala Ala Pro Ser Ala Pro 
        195                 200                 205             


Tyr Gly Leu Leu Ser Gly Tyr Pro Ala Leu Tyr Pro Ala Pro Gln Tyr 
    210                 215                 220                 


Gln Gly His Phe Gln Leu Phe Arg Gly Leu Ala Ala Pro Ser Ala Gly 
225                 230                 235                 240 


Pro Thr Ala Pro Pro Ser Phe Leu Asn Cys Leu Gly Pro Gly Ala Val 
                245                 250                 255     


Gly Thr Glu Leu Gly Ala Thr Ala Ile Ala Gly Asp Ala Gly Leu Ser 
            260                 265                 270         


Pro Gly Ala Ala Pro Pro Lys Arg Ser Arg Arg Thr Leu Ala Gln Lys 
        275                 280                 285             


Arg Gln Ala Ala His Thr Cys Gly His Glu Gly Cys Gly Lys Ser Tyr 
    290                 295                 300                 


Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu 
305                 310                 315                 320 


Lys Pro Tyr Ala Cys Ser Trp Asp Gly Cys Asn Trp Arg Phe Ala Arg 
                325                 330                 335     


Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly His Arg Pro 
            340                 345                 350         


Phe Cys Cys Gly Leu Cys Pro Arg Ala Phe Ser Arg Ser Asp His Leu 
        355                 360                 365             


Ala Leu His Met Lys Arg His Leu 
    370                 375     


<210>  3
<211>  362
<212>  PRT
<213>  Homo sapients

<400>  3

Met Ala Thr Ala Glu Thr Ala Leu Pro Ser Ile Ser Thr Leu Thr Ala 
1               5                   10                  15      


Leu Gly Pro Phe Pro Asp Thr Gln Asp Asp Phe Leu Lys Trp Trp Arg 
            20                  25                  30          


Ser Glu Glu Ala Gln Asp Met Gly Pro Gly Pro Pro Asp Pro Thr Glu 
        35                  40                  45              


Pro Pro Leu His Val Lys Ser Glu Asp Gln Pro Gly Glu Glu Glu Asp 
    50                  55                  60                  


Asp Glu Arg Gly Ala Asp Ala Thr Trp Asp Leu Asp Leu Leu Leu Thr 
65                  70                  75                  80  


Asn Phe Ser Gly Pro Glu Pro Gly Gly Ala Pro Gln Thr Cys Ala Leu 
                85                  90                  95      


Ala Pro Ser Glu Ala Ser Gly Ala Gln Tyr Pro Pro Pro Pro Glu Thr 
            100                 105                 110         


Leu Gly Ala Tyr Ala Gly Gly Pro Gly Leu Val Ala Gly Leu Leu Gly 
        115                 120                 125             


Ser Glu Asp His Ser Gly Trp Val Arg Pro Ala Leu Arg Ala Arg Ala 
    130                 135                 140                 


Pro Asp Ala Phe Val Gly Pro Ala Leu Ala Pro Ala Pro Ala Pro Glu 
145                 150                 155                 160 


Pro Lys Ala Leu Ala Leu Gln Pro Val Tyr Pro Gly Pro Gly Ala Gly 
                165                 170                 175     


Ser Ser Gly Gly Tyr Phe Pro Arg Thr Gly Leu Ser Val Pro Ala Ala 
            180                 185                 190         


Ser Gly Ala Pro Tyr Gly Leu Leu Ser Gly Tyr Pro Ala Met Tyr Pro 
        195                 200                 205             


Ala Pro Gln Tyr Gln Gly His Phe Gln Leu Phe Arg Gly Leu Gln Gly 
    210                 215                 220                 


Pro Ala Pro Gly Pro Ala Thr Ser Pro Ser Phe Leu Ser Cys Leu Gly 
225                 230                 235                 240 


Pro Gly Thr Val Gly Thr Gly Leu Gly Gly Thr Ala Glu Asp Pro Gly 
                245                 250                 255     


Val Ile Ala Glu Thr Ala Pro Ser Lys Arg Gly Arg Arg Ser Trp Ala 
            260                 265                 270         


Arg Lys Arg Gln Ala Ala His Thr Cys Ala His Pro Gly Cys Gly Lys 
        275                 280                 285             


Ser Tyr Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Tyr Ala Cys Thr Trp Glu Gly Cys Gly Trp Arg Phe 
305                 310                 315                 320 


Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly Gln 
                325                 330                 335     


Arg Pro Phe Arg Cys Gln Leu Cys Pro Arg Ala Phe Ser Arg Ser Asp 
            340                 345                 350         


His Leu Ala Leu His Met Lys Arg His Leu 
        355                 360         


<210>  4
<211>  362
<212>  PRT
<213>  Pan troglodytes

<400>  4

Met Ala Thr Ala Glu Thr Ala Leu Pro Ser Ile Ser Thr Leu Thr Ala 
1               5                   10                  15      


Leu Gly Pro Phe Pro Asp Thr Gln Asp Asp Phe Leu Lys Trp Trp Arg 
            20                  25                  30          


Ser Glu Glu Ala Gln Asp Met Gly Pro Gly Pro Pro Asp Pro Thr Glu 
        35                  40                  45              


Pro Pro Leu His Val Lys Ser Glu Asp Gln Pro Gly Glu Glu Glu Asp 
    50                  55                  60                  


Asp Glu Arg Gly Ala Asp Ala Thr Trp Asp Leu Asp Leu Leu Leu Thr 
65                  70                  75                  80  


Asn Phe Ser Gly Pro Glu Pro Gly Gly Ala Pro Gln Thr Cys Ala Leu 
                85                  90                  95      


Ala Pro Ser Glu Ala Pro Gly Ala Gln Tyr Pro Pro Pro Pro Glu Thr 
            100                 105                 110         


Leu Gly Ala Tyr Ala Gly Gly Pro Gly Leu Val Ala Gly Leu Leu Gly 
        115                 120                 125             


Ser Glu Asp His Ser Gly Trp Val Arg Pro Ala Leu Arg Ala Arg Ala 
    130                 135                 140                 


Pro Asp Ala Phe Val Gly Pro Ala Leu Ala Pro Ala Pro Ala Pro Glu 
145                 150                 155                 160 


Pro Lys Ala Leu Ala Leu Gln Pro Val Tyr Pro Gly Pro Gly Ala Gly 
                165                 170                 175     


Ser Ser Gly Gly Tyr Phe Pro Arg Thr Gly Leu Ser Val Pro Ala Ala 
            180                 185                 190         


Ser Gly Ala Pro Tyr Gly Leu Leu Ser Gly Tyr Pro Ala Met Tyr Pro 
        195                 200                 205             


Ala Pro Gln Tyr Gln Gly His Phe Gln Leu Phe Arg Gly Leu Gln Gly 
    210                 215                 220                 


Pro Ala Pro Gly Pro Ala Thr Ser Pro Ser Phe Leu Ser Cys Leu Gly 
225                 230                 235                 240 


Pro Gly Thr Val Gly Thr Gly Leu Gly Gly Thr Ala Glu Asp Pro Gly 
                245                 250                 255     


Val Ile Ala Glu Thr Ala Pro Ser Lys Arg Gly Arg Arg Ser Trp Ala 
            260                 265                 270         


Arg Lys Arg Gln Ala Ala His Thr Cys Ala His Pro Gly Cys Gly Lys 
        275                 280                 285             


Ser Tyr Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Tyr Ala Cys Thr Trp Glu Gly Cys Gly Trp Arg Phe 
305                 310                 315                 320 


Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly Gln 
                325                 330                 335     


Arg Pro Phe Arg Cys Gln Leu Cys Pro Arg Ala Phe Ser Arg Ser Asp 
            340                 345                 350         


His Leu Ala Leu His Met Lys Arg His Leu 
        355                 360         


<210>  5
<211>  362
<212>  PRT
<213>  Macaca mulatta

<400>  5

Met Ala Thr Ala Lys Thr Ala Leu Pro Ser Ile Ser Thr Leu Thr Ala 
1               5                   10                  15      


Leu Gly Pro Phe Pro Asp Thr Gln Asp Asp Phe Leu Lys Trp Trp Arg 
            20                  25                  30          


Ser Glu Glu Ala Gln Asp Met Gly Pro Gly Pro Pro Asp Pro Thr Glu 
        35                  40                  45              


Pro Pro Leu His Val Lys Ser Glu Asp Gln Pro Gly Glu Glu Glu Asp 
    50                  55                  60                  


Asp Glu Arg Gly Ala Asp Ala Thr Trp Asp Leu Asp Leu Phe Leu Thr 
65                  70                  75                  80  


Asn Phe Ser Gly Pro Glu Pro Gly Gly Ala Pro Gln Thr Cys Ala Leu 
                85                  90                  95      


Ala Pro Ser Glu Ala Pro Gly Val Gln Tyr Pro Pro Pro Pro Glu Thr 
            100                 105                 110         


Leu Gly Ala Tyr Ala Gly Gly Pro Gly Met Val Ala Gly Leu Leu Gly 
        115                 120                 125             


Ser Glu Asp His Ser Gly Trp Val Arg Pro Ala Leu Arg Ala Pro Ala 
    130                 135                 140                 


Pro Asp Ala Phe Val Gly Pro Ala Leu Ala Pro Ala Pro Ala Pro Glu 
145                 150                 155                 160 


Pro Lys Ala Leu Ala Leu Gln Pro Val Tyr Pro Gly Pro Gly Ala Gly 
                165                 170                 175     


Ser Ser Gly Gly Tyr Phe Gln Arg Thr Gly Leu Ser Val Pro Ala Ala 
            180                 185                 190         


Ser Gly Ala Pro Tyr Gly Leu Leu Ser Gly Tyr Pro Ala Val Tyr Pro 
        195                 200                 205             


Ala Pro Gln Tyr Gln Gly His Phe Gln Leu Phe Arg Gly Leu Gln Gly 
    210                 215                 220                 


Pro Ala Pro Gly Pro Ala Thr Ser Pro Ser Phe Leu Ser Cys Leu Gly 
225                 230                 235                 240 


Pro Gly Thr Val Gly Thr Gly Leu Gly Gly Thr Ala Gly Asp Pro Gly 
                245                 250                 255     


Val Ile Ala Glu Ala Ala Pro Ser Lys Arg Gly Arg Arg Ser Trp Ala 
            260                 265                 270         


Arg Lys Arg Gln Ala Ala His Thr Cys Ala His Pro Gly Cys Gly Lys 
        275                 280                 285             


Ser Tyr Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Tyr Ala Cys Thr Trp Glu Gly Cys Gly Trp Arg Phe 
305                 310                 315                 320 


Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly Gln 
                325                 330                 335     


Arg Pro Phe Arg Cys Gln Leu Cys Pro Arg Ala Phe Ser Arg Ser Asp 
            340                 345                 350         


His Leu Ala Leu His Met Lys Arg His Leu 
        355                 360         


<210>  6
<211>  369
<212>  PRT
<213>  Canis lupus

<400>  6

Met Ala Thr Ala Glu Thr Ala Leu Pro Ser Ile Ser Thr Leu Thr Thr 
1               5                   10                  15      


Leu Gly Pro Phe Pro Asp Thr Gln Glu Asp Phe Leu Lys Trp Trp Arg 
            20                  25                  30          


Ser Glu Glu Val Gln Asp Leu Gly Pro Gly Pro Pro Asp Pro Thr Gly 
        35                  40                  45              


Leu Pro Leu His Val Arg Pro Glu Ser Gln Asp Ala Pro Gly Glu Asp 
    50                  55                  60                  


Glu Asp Asp Glu Arg Asp Ser Ala Thr Ala Trp Asp Leu Asp Leu Leu 
65                  70                  75                  80  


Leu Thr Asn Phe Pro Cys Pro Glu Pro Gly Gly Ala Pro Gln Thr Cys 
                85                  90                  95      


Ala Leu Ala Pro Gly Glu Cys Ser Gly Val Gln Phe Pro Pro Pro Pro 
            100                 105                 110         


Leu Pro Pro Pro Gln Ala Pro Glu Thr Pro Cys Pro Tyr Val Gly Gly 
        115                 120                 125             


Pro Gly Leu Val Ala Gly Leu Leu Gly Pro Glu Glu His Pro Gly Trp 
    130                 135                 140                 


Ala Arg Pro Ala Pro Arg Ala Pro Val Pro Asp Ala Phe Val Gly Ser 
145                 150                 155                 160 


Ala Leu Gly Pro Ala Pro Glu Pro Lys Pro Leu Pro Leu Gln Pro Val 
                165                 170                 175     


Tyr Pro Gly Pro Gly Ala Gly Ser Ser Gly Ser Tyr Phe Ser Arg Thr 
            180                 185                 190         


Gly Leu Ser Val Pro Thr Ala Pro Gly Ala Pro Tyr Gly Leu Leu Pro 
        195                 200                 205             


Gly Tyr Pro Pro Leu Tyr Pro Val Pro Gln Tyr Gln Gly His Phe Gln 
    210                 215                 220                 


Leu Phe Arg Gly Leu Pro Ala Pro Ala Pro Gly Pro Thr Ser Pro Pro 
225                 230                 235                 240 


Ser Phe Leu Ser Cys Leu Gly Pro Gly Thr Ala Gly Ser Gly Leu Arg 
                245                 250                 255     


Gly Thr Ala Gly Asp Pro Gly Gly Val Ala Asp Ala Ala Pro Ser Lys 
            260                 265                 270         


Arg Ser Arg Arg Ser Trp Ala Arg Lys Arg Gln Ala Ala His Thr Cys 
        275                 280                 285             


Thr His Pro Gly Cys Gly Lys Ser Tyr Thr Lys Ser Ser His Leu Lys 
    290                 295                 300                 


Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Thr Trp 
305                 310                 315                 320 


Asp Gly Cys Gly Trp Arg Phe Ala Arg Ser Asp Glu Leu Thr Arg His 
                325                 330                 335     


Tyr Arg Lys His Thr Gly Gln Arg Pro Phe Arg Cys Gln Leu Cys Pro 
            340                 345                 350         


Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His 
        355                 360                 365             


Leu 
    


<210>  7
<211>  372
<212>  PRT
<213>  Bos taurus

<400>  7

Met Ala Ala Ala Glu Thr Ala Leu Pro Ser Ile Ser Thr Leu Thr Ala 
1               5                   10                  15      


Leu Gly Pro Phe Ser Asp Thr Gln Glu Asp Ile Leu Lys Trp Trp Arg 
            20                  25                  30          


Ser Glu Asp Val Gln Asp Leu Gly Pro Gly Pro Pro Asp His Thr Gly 
        35                  40                  45              


Pro Pro Leu His Val Arg Pro Glu Leu Glu Asp Ala Pro Gly Glu Asp 
    50                  55                  60                  


Glu Asp Asp Asp Arg Asp Ala Ala Thr Pro Trp Asp Leu Asp Leu Leu 
65                  70                  75                  80  


Phe Thr Asn Phe Pro Cys Pro Glu Pro Gly Gly Ala Pro Gln Thr Cys 
                85                  90                  95      


Ala Pro Gln Thr Cys Ala Pro Gln Ala Cys Ala Leu Ala Pro Ser Glu 
            100                 105                 110         


Gly Ser Gly Ala Gln Phe Pro Pro Pro Pro Glu Thr Leu Gly Ala Tyr 
        115                 120                 125             


Ala Gly Gly Pro Gly Leu Val Ala Gly Leu Leu Gly Pro Glu Glu His 
    130                 135                 140                 


Leu Gly Trp Ala Arg Pro Ala Pro Arg Thr Pro Ala Pro Asp Thr Phe 
145                 150                 155                 160 


Val Gly Pro Ser Leu Ile Pro Thr Pro Glu Pro Lys Ala Leu Pro Leu 
                165                 170                 175     


Gln Pro Leu Tyr Pro Gly Pro Gly Ser Gly Ser Ser Gly Ser Tyr Phe 
            180                 185                 190         


Pro Arg Thr Gly Leu Ser Val Pro Ala Ala Pro Gly Ala Pro Tyr Gly 
        195                 200                 205             


Leu Leu Ser Gly Tyr Pro Ala Leu Tyr Pro Met Pro Gln Tyr Gln Gly 
    210                 215                 220                 


His Phe Gln Leu Phe Arg Gly Leu Gln Ala Pro Ala Pro Gly Pro Pro 
225                 230                 235                 240 


Ser Pro His Ser Phe Leu Ser Cys Leu Gly Pro Gly Thr Thr Gly Ala 
                245                 250                 255     


Gly Leu Gly Gly Thr Thr Gly Asp Pro Gly Gly Thr Thr Glu Ala Ala 
            260                 265                 270         


Pro Ser Lys Arg Ser Arg Arg Ser Trp Ala Arg Lys Arg Gln Ala Ala 
        275                 280                 285             


His Thr Cys Thr His Pro Gly Cys Gly Lys Ser Tyr Thr Lys Ser Ser 
    290                 295                 300                 


His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr Ala 
305                 310                 315                 320 


Cys Thr Trp Asp Gly Cys Gly Trp Arg Phe Ala Arg Ser Asp Glu Leu 
                325                 330                 335     


Thr Arg His Tyr Arg Lys His Thr Gly Gln Arg Pro Phe Arg Cys Gln 
            340                 345                 350         


Leu Cys Ser Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu His Met 
        355                 360                 365             


Lys Arg His Leu 
    370         


<210>  8
<211>  4946
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EKLF-PGK knock-in cassette

<400>  8
gtgggcagac aggagccctc caagaaactt tcctagcctc atagcccatg aggcagaaga       60

gagagaggag gcctgaggtc cagggtggac accagccagc catggcctca gctgagactg      120

tcttaccctc catcagtaca ctcaccaccc tgggacagtt cctggacacc caggaggact      180

tcctcaaggt ggggccagtg tgagtgtgtg ggagggggca ggtggtcttg catagggcat      240

agtgcttagg ggtggggcgt ctatcttact ttaatatcct ctgctctgtt ttttgggggt      300

ggaggagtgg gagagcctct gagccttgtt tgggggagat gttctagggg tctgagatca      360

aggtgaggtg acactataga atactcaagc tatcgagata acttcgtata atgtatgcta      420

tacgaagtta tcgcgccgca cacaaaaacc aacacacaga tcatgaaaat aaagctcttt      480

tattggtacc gaattcgcca gggagctctc agacgtcgct tggtcggtct ttattcgaac      540

cccagagtcc cgctcagaag aactcgtcaa gaaggcgata gaaggcgatg cgctgcgaat      600

cgggggcggc gataccgtaa agcacgagga agcggtcagc ccattcgccg ccaagctctt      660

cagcaatatc acgggtagcc aacgctatgt cctgatagcg gtccgccaca cccagccggc      720

cacagtcgat gaatccagaa aagcggccat tttccaccat gatattcggc aagcaggcat      780

cgccatgggt cacgacgaga tcctcgccgt cgggcatgcg cgccttgagc ctggcgaaca      840

gttcggctgg cgcgagcccc tgatgctctt cgtccagatc atcctgatcg acaagaccgg      900

cttccatccg agtacgtgct cgctcgatgc gatgtttcgc ttggtggtcg aatgggcagg      960

tagccggatc aagcgtatgc agccgccgca ttgcatcagc catgatggat actttctcgg     1020

caggagcaag gtgagatgac aggagatcct gccccggcac ttcgcccaat agcagccagt     1080

cccttcccgc ttcagtgaca acgtcgagca cagctgcgca aggaacgccc gtcgtggcca     1140

gccacgatag ccgcgctgcc tcgtcctgca gttcattcag ggcaccggac aggtcggtct     1200

tgacaaaaag aaccgggcgc ccctgcgctg acagccggaa cacggcggca tcagagcagc     1260

cgatcgtctg ttgtgcccag tcatagccga atagcctctc cacccaagcg gccggagaac     1320

ctgcgtgcaa tccatcttgt tcaatggccg atcccatggt ttagttcctc accttgtcgt     1380

attatactat gccgatatac tatgccgatg attaattgtc aacacgtgct gctgcaggtc     1440

gaaaggcccg gagatgagga agaggagaac agcgcggcag acgtgcgctt ttgaagcgtg     1500

cagaatgccg ggcctccgga ggaccttcgg gcgcccgccc cgcccctgag cccgcccctg     1560

agcccgcccc cggacccacc ccttcccagc ctctgagccc agaaagcgaa ggagcaaagc     1620

tgctattggc cgctgcccca aaggcctacc cgcttccatt gctcagcggt gctgtccatc     1680

tgcacgagac tagtgagacg tgctacttcc atttgtcacg tcctgcacga cgcgagctgc     1740

ggggcggggg ggaacttcct gactagggga ggagtagaag gtggcgcgac ggggccacca     1800

aagaacggag ccggttggcg cctaccggtg gatgtggaat gtgtgcgagg ccagaggcca     1860

cttgtgtagc gccaagtgcc cagcggggct gctaaagcgc atgctccaga ctgccttggg     1920

aaaagcgcct cccctacccg gtagaatata acttcgtata atgtatgcta tacgaagtta     1980

tgcggcccta gtgatttagg ctcatagaga caaaggtcca gataaaggtg tcctgggatt     2040

tccaggcttt gagctgtaat tttctgggct atgtgaagac agggaaaggc tagggaaaac     2100

ggagtcgaag ctgtcccctt tgactcagaa ctctgcaacc ccttctccca tcctgaatac     2160

tattcttggt aagtgtctta gctgtctcta gcaagaccta atggagttgt ctggagctga     2220

gaaaggggtt aggggaaccg tgtgggtaaa tgacaggcac caacggtgtt tccagccagg     2280

gttgtttgag ggccaggtac ccagtgccta ccattcaagc agtacgctcc ctcccgcagt     2340

ggtggcggtc tgaggagacg caggatttgg ggccggggcc cccgaatccc acggggccgt     2400

cccatcacgt gagtctgaga tcggaggacc cttccggaga ggacgatgag agggacgtga     2460

cctgtgcgtg ggacccggat cttttcctta caaactttcc aggttccgag tctcccggca     2520

cttcccggac ctgtgccctg gcgcccagcg tggggccagt ggcacagttc gagccgcctg     2580

agtctctggg cgcctatgcg ggtggcccag ggttggtgac tgggcctttg ggctccgagg     2640

agcacacaag ctgggcgcac ccgactccga gacccccagc ccctgaaccc ttcgtggccc     2700

ctgccctggc cccgggactc gctcccaagg ctcagccctc gtactccgac tcgcgagcgg     2760

gctccgtagg gggcttcttc ccgcgggcgg ggcttgcggt gcccgcagct ccaggcgccc     2820

cctatgggct gctgtcggga taccccgcgc tgtaccccgc gccacagtac caaggccact     2880

tccagctctt tcgcgggctc gcggcgcctt ctgctggtcc cacggcgccc ccttccttct     2940

tgaattgtct gggacctggg actgtggcca cagaactcgg ggccactgcg atcgccggag     3000

acgcaggctt gtccccggga actgcgccgc ccaaacgcag ccggcgaact ttggcaccta     3060

agaggcaggc ggcacatacg tgcgggcacg aaggctgcgg gaagagctac accaagagct     3120

cgcacctcaa ggcgcacctg cgcacgcaca cgggtaaggg cggggccaga cgggcggggg     3180

cggggcggga gccgctagtg aacgaaggga ggggccggag ggtagtcaga ggcgtggcta     3240

aaggcggccc cagttctagg ggtcgtgaag accgcacctg agacactggg tcaagtctag     3300

aaggggcgat tccagaccca aatgggctaa tacaaacact cgggaggcag aggcaggtgg     3360

atagcagtga cttcgaggcc atttgggcta ttatagcgag tttcagcagc ctgagctact     3420

tagtgagatc ctggttcata aataaatagg tgtaacagag gacctgggga acactttggg     3480

gacttcggtg ttagaagtgg atgtgtaagg cctgggttag agatgggaga agaaactaga     3540

ggggtgaacc cgaaaggtac aagcttggaa tgccagagct caggatatag ccagtattta     3600

catgcatgct cgagctggaa ccatctggga tcaggaggtt gagacactca agtaaaatca     3660

gtttcagggg caactgacag aggtcccaga gttaagaaaa gaagagaagg gggctggaga     3720

gatggctcag tggttaagag cactgactgc tcttccagag gtcctgagtt taaatcccag     3780

caccacatgg tggctcacaa ccatctgtaa tgggatccga tgccctcttc tggtgtgact     3840

gaagacagct acagtgtact tacatataat aaataaataa attaaaaaaa aaaagaaaga     3900

aagaaaaaag aaaagaagag aaggaaatgc tgagagacag ggcctagaaa gagaaacggg     3960

gtcatcccag gactggaaga cagctgaggg tctcccaagc atggcagggc acgcaacagg     4020

ctgtaacagg aagagaggga atcaccagag acagggcctt gaacactggg gtggatttct     4080

gggcttgaac caagttgagg aacaagactg gatatcatcg ggaggctctg ccagagcaag     4140

aaatagctgc aacgcggaga acaaagaacg aaggtgcagc cacataaaaa ggcagggaac     4200

tagcacaccg gaagtgggat aggagaccgg aagtgagaaa actgcaggat tgcagctgta     4260

gatacagaaa aggattgagt cacagaaggc aggattatgt gaccttttaa ctgtgtgggc     4320

taggtatgtc ctaagacttg gctctacttc atcaagggtg caaactggag ctgggttgct     4380

tggagggtgg tacttacagc tccctgtcct tcaggagaga agccttatgc ctgctcctgg     4440

gacggctgtg actggaggtt cgctcgctca gacgaactga cgcgccacta ccggaagcac     4500

actggacatc gtcccttctg ctgtggcctc tgcccacgtg ctttttcacg ctctgaccac     4560

ttagctctgc acatgaagcg tcacctctga gtgatcctgc acaaggactg gggatgaaat     4620

aagagtggat ccaaggaccg tatcccaaaa gatgggccat tatatagtcc tacccagatc     4680

aaaaactgac cagaagacca tacaaaggag ccttcaggac aaacctcaca tgtcctcagg     4740

gagccccaca catggcccca cagacccagc aatatagacc accagataaa tcaactcaaa     4800

tggaccccta gaccagagga gtgaccctgt gtcctggacg cagatggact ggggtgagat     4860

ttcctaagat ctagaaggga gcttcacact gtgcccatct gctaggattg ttgtcgttac     4920

tataaaaatt tcccatataa aaccag                                          4946


<210>  9
<211>  2782
<212>  DNA
<213>  Homo sapiens

<400>  9
tcagagttca cgaggcagcc gaggaagagg aggcttgagg cccagggtgg gcaccagcca       60

gccatggcca cagccgagac cgccttgccc tccatcagca cactgaccgc cctgggcccc      120

ttcccggaca cacaggatga cttcctcaag gtggggccta gaaggtgggg tctaggtggg      180

ctggctggaa tccagggcca cagtcacaga tcttggggtc cagacctgca tcttgacctg      240

aaatcaagag acttaaccag gactgaggta cgctcagtcc aggagaggag atctcagctt      300

agtctggcag ggggtgagga gggtggtcta ggggtttgag gttctaagtg tgatctattt      360

cggtaataga aaacgaaggt agcctgggca acatggtgaa accctatctc tacaaaaaat      420

accaaaaaca ttaggccagg catgggggcg tgtgcctgta gtcccaggta ctccgtaggc      480

tgatgcagga ggatcattag agcccaggag attaaggata cagtgagctg caccactgca      540

ctccagcctg ggcaaaagag taagacccta tctcaagaaa aaaaaaaaaa aaaaggaacg      600

agatctaggc tcacagacaa tcttccagat atcagcggga aatgatgagt gtgtctgggg      660

gacatccaaa atttcggaat taatcttgtt ttgggagaca gggaaggaga gggatgttct      720

gggggaaaac taagtcaagg ctggcatcct ctcccccgtc ccctgccagt tttccatctc      780

cagcagctct gctacccctt cccccatccc cgagtgtggt tccagatagt ggaagtctta      840

tctcctgtct ccagccagac ctgatcggtt tctgtccctg gagctggggg gggagcgggg      900

agaggggcgg ttagaggggc agtgttgggg aagtgggaca gacagacagg caaacaagac      960

ccctttccaa agcctctgcg tcagagtgtc cagcccgcga tgtccctggg cagggcaccc     1020

cagtgtccac cgaacctcga gctgcctgct ccctcccgca gtggtggcgc tccgaagagg     1080

cgcaggacat gggcccgggt cctcctgacc ccacggagcc gcccctccac gtgaagtctg     1140

aggaccagcc cggggaggaa gaggacgatg agaggggcgc ggacgccacc tgggacctgg     1200

atctcctcct caccaacttc tcgggcccgg agcccggtgg cgcgccccag acctgcgctc     1260

tggcgcccag cgaggcctcc ggggcgcaat atccgccgcc gcccgagact ctgggcgcat     1320

atgctggcgg cccggggctg gtggctgggc ttttgggttc ggaggatcac tcgggttggg     1380

tgcgccctgc cctgcgagcc cgggctcccg acgccttcgt gggcccagcc ctggctccag     1440

ccccggcccc cgagcccaag gcgctggcgc tgcaaccggt gtacccgggg cccggcgccg     1500

gctcctcggg tggctacttc ccgcggaccg ggctttcagt gcctgcggcg tcgggcgccc     1560

cctacgggct actgtccggg taccccgcga tgtacccggc gcctcagtac caagggcact     1620

tccagctctt ccgcgggctc cagggacccg cgcccggtcc cgccacgtcc ccctccttcc     1680

tgagttgttt gggacccggg acggtgggca ctggactcgg ggggactgca gaggatccag     1740

gtgtgatagc cgagaccgcg ccatccaagc gaggccgacg ttcgtgggcg cgcaagaggc     1800

aggcagcgca cacgtgcgcg cacccgggtt gcggcaagag ctacaccaag agctcccacc     1860

tgaaggcgca tctgcgcacg cacacaggtg agggggcggg gccccggaca tgagaaaggg     1920

cgcggcgccc gctgtagtta caggggaaga agggttgcag agggcgggac ttggacttgg     1980

ctggcctctg agagtgagtg cctccttaaa ttttgtgccc taggggcctc actttgttca     2040

tcctagtccc agcccaggct gagtaaaggg gtgtggccag atgcagggga cccggggaca     2100

tgactgggca gacagtggcg cttatggctt ccttgtcccc taggggagaa gccatacgcc     2160

tgcacgtggg aaggctgcgg ctggagattc gcgcgctcgg acgagctgac ccgccactac     2220

cggaaacaca cggggcagcg ccccttccgc tgccagctct gcccacgtgc tttttcgcgc     2280

tctgaccacc tggccttgca catgaagcgc cacctttgag ccctgccctg gcacttggac     2340

tctcctagtg actggggatg ggacaagaag cctgtttggt ggtctcttca cacggacgcg     2400

cgtgacacaa tgctgggtgg ttttcccacg aatggaccct ctcctggact cgcgttccca     2460

aagatccacc caaatatcaa acacggaccc atagacagcc ctgggggagc ctcttacgga     2520

aaatccgaca agccttcagc cacagggagc cacacagaga tgtccaaact gtcgtgcaaa     2580

cccagtgaga cagaccgcca aataaacgga ctcagtggac actcagacca gctcccagat     2640

ggccctggac agcaggagag ggtgtgggat gaggcttccc agagaccctg ggtctagaaa     2700

gcggctcctg aaggtccctt attgtggctg atattaactg tcaatggtta tgggtcctat     2760

aaaaatgccc ctcccagata aa                                              2782


<210>  10
<211>  3368
<212>  DNA
<213>  Mus musculus

<400>  10
gtgggcagac aggagccctc caagaaactt tcctagcctc atagcccatg aggcagaaga       60

gagagaggag gcctgaggtc cagggtggac accagccagc catggcctca gctgagactg      120

tcttaccctc catcagtaca ctcaccaccc tgggacagtt cctggacacc caggaggact      180

tcctcaaggt ggggccagtg tgagtgtgtg ggagggggca ggtggtcttg catagggcat      240

agtgcttagg ggtggggcgt ctatcttact ttaatatcct ctgctctgtt ttttgggggt      300

ggaggagtgg gagagcctct gagccttgtt tgggggagat gttctagggg tctgagatca      360

aggtgaggcc tatttctcca acaggaagca gaattctaag ctctatatct taagagacta      420

ggctcataga gacaaaggtc cagataaagg tgtcctggga tttccaggct ttgagctgta      480

attttctggg ctatgtgaag acagggaaag gctagggaaa acggagtcga agctgtcccc      540

tttgactcag aactctgcaa ccccttctcc catcctgaat actattcttg gtaagtgtct      600

tagctgtctc tagcaagacc taatggagtt gtctggagct gagaaagggg ttaggggaac      660

cgtgtgggta aatgacaggc accaacggtg tttccagcca gggttgtttg agggccaggt      720

acccagtgcc taccattcaa gcagtacgct ccctcccgca gtggtggcgg tctgaggaga      780

cgcaggattt ggggccgggg cccccgaatc ccacggggcc gtcccatcac gtgagtctga      840

aatcggagga cccttccgga gaggacgatg agagggacgt gacctgtgcg tgggacccgg      900

atcttttcct tacaaacttt ccaggttccg agtctcccgg cacttcccgg acctgtgccc      960

tggcgcccag cgtggggcca gtggcacagt tcgagccgcc tgagtctctg ggcgcctatg     1020

cgggtggccc agggttggtg actgggcctt tgggctccga ggagcacaca agctgggcgc     1080

acccgactcc gagaccccca gcccctgaac ccttcgtggc ccctgccctg gccccgggac     1140

tcgctcccaa ggctcagccc tcgtactccg actcgcgagc gggctccgta gggggcttct     1200

tcccgcgggc ggggcttgcg gtgcccgcag ctccaggcgc cccctatggg ctgctgtcgg     1260

gataccccgc gctgtacccc gcgccacagt accaaggcca cttccagctc tttcgcgggc     1320

tcgcggcgcc ttctgctggt cccacggcgc ccccttcctt cttgaattgt ctgggacctg     1380

ggactgtggc cacagaactc ggggccactg cgatcgccgg agacgcaggc ttgtccccgg     1440

gaactgcgcc gcccaaacgc agccggcgaa ctttggcacc taagaggcag gcggcacata     1500

cgtgcgggca cgaaggctgc gggaagagct acaccaagag ctcgcacctc aaggcgcacc     1560

tgcgcacgca cacgggtaag ggcggggcca gacgggcggg ggcggggcgg gagccgctag     1620

tgaacgaagg gaggggccgg agggtagtca gaggcgtggc taaaggcggc cccagttcta     1680

ggggtcgtga agaccgcacc tgagacactg ggtcaagtct agaaggggcg attccagacc     1740

caaatgggct aatacaaaca ctcgggaggc agaggcaggt ggatagcagt gacttcgagg     1800

ccatttgggc tattatagcg agtttcagca gcctgagcta cttagtgaga tcctggttca     1860

taaataaata ggtgtaacag aggacctggg gaacactttg gggacttcgg tgttagaagt     1920

ggatgtgtaa ggcctgggtt agagatggga gaagaaacta gaggggtgaa cccgaaaggt     1980

acaagcttgg aatgccagag ctcaggatat agccagtatt tacatgcatg ctcgagctgg     2040

aaccatctgg gatcaggagg ttgagacact caagtaaaat cagtttcagg ggcaactgac     2100

agaggtccca gagttaagaa aagaagagaa gggggctgga gagatggctc agtggttaag     2160

agcactgact gctcttccag aggtcctgag tttaaatccc agcaccacat ggtggctcac     2220

aaccatctgt aatgggatcc gatgccctct tctggtgtga ctgaagacag ctacagtgta     2280

cttacatata ataaataaat aaattaaaaa aaaaaagaaa gaaagaaaaa agaaaagaag     2340

agaaggaaat gctgagagac agggcctaga aagagaaacg gggtcatccc aggactggaa     2400

gacagctgag ggtctcccaa gcatggcagg gcacgcaaca ggctgtaaca ggaagagagg     2460

gaatcaccag agacagggcc ttgaacactg gggtggattt ctgggcttga accaagttga     2520

ggaacaagac tggatatcat cgggaggctc tgccagagca agaaatagct gcaacgcgga     2580

gaacaaagaa cgaaggtgca gccacataaa aaggcaggga actagcacac cggaagtggg     2640

ataggagacc ggaagtgaga aaactgcagg attgcagctg tagatacaga aaaggattga     2700

gtcacagaag gcaggattat gtgacctttt aactgtgtgg gctaggtatg tcctaagact     2760

tggctctact tcatcaaggg tgcaaactgg agctgggttg cttggagggt ggtacttaca     2820

gctccctgtc cttcaggaga gaagccttat gcctgctcct gggacggctg tgactggagg     2880

ttcgctcgct cagacgaact gacgcgccac taccggaagc acactggaca tcgtcccttc     2940

tgctgtggcc tctgcccacg tgctttttca cgctctgacc acttagctct gcacatgaag     3000

cgtcacctct gagtgatcct gcacaaggac tggggatgaa ataagagtgg atccaaggac     3060

cgtatcccaa aagatgggcc attatatagt cctacccaga tcaaaaactg accagaagac     3120

catacaaagg agccttcagg acaaacctca catgtcctca gggagcccca cacatggccc     3180

cacagaccca gcaatataga ccaccagata aatcaactca aatggacccc tagaccagag     3240

gagtgaccct gtgtcctgga cgcagatgga ctggggtgag atttcctaag atctagaagg     3300

gagcttcaca ctgtgcccat ctgctaggat tgttgtcgtt actataaaaa tttcccatat     3360

aaaaccag                                                              3368


