                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS OF DIAGNOSING AND TREATING CANCER

<130>  BIO14125 POIROT / MC

<160>  16    

<170>  PatentIn version 3.3

<210>  1
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Phe Met Lys Lys Tyr Leu Leu Pro Ile Leu Gly Leu Phe Met 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Ala Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ala Lys Met Gly Ala His Val Val Val Thr 
    50                  55                  60                  


Ala Arg Ser Lys Glu Thr Leu Gln Lys Val Val Ser His Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Val Ala Gln Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Asn Thr Ser Leu Asn Leu 
        115                 120                 125             


Phe His Asp Asp Ile His His Val Arg Lys Ser Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Leu Thr Val Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Val Val Val Ser Ser Leu Ala Gly Lys Val Ala 
                165                 170                 175     


Tyr Pro Met Val Ala Ala Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Ser Ile Arg Lys Glu Tyr Ser Val Ser Arg Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Ala Val Ser Gly Ile Val His Met Gln Ala Ala Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Gly Ala Leu Arg Gln Glu Glu Val 
                245                 250                 255     


Tyr Tyr Asp Ser Ser Leu Trp Thr Thr Leu Leu Ile Arg Asn Pro Cys 
            260                 265                 270         


Arg Lys Ile Leu Glu Phe Leu Tyr Ser Thr Ser Tyr Asn Met Asp Arg 
        275                 280                 285             


Phe Ile Asn Lys 
    290         


<210>  2
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Arg Trp Pro Trp Pro Ser Gly Gly Ala Trp Leu Leu Val Ala 
1               5                   10                  15      


Ala Arg Ala Leu Leu Gln Leu Leu Arg Ser Asp Leu Arg Leu Gly Arg 
            20                  25                  30          


Pro Leu Leu Ala Ala Leu Ala Leu Leu Ala Ala Leu Asp Trp Leu Cys 
        35                  40                  45              


Gln Arg Leu Leu Pro Pro Pro Ala Ala Leu Ala Val Leu Ala Ala Ala 
    50                  55                  60                  


Gly Trp Ile Ala Leu Ser Arg Leu Ala Arg Pro Gln Arg Leu Pro Val 
65                  70                  75                  80  


Ala Thr Arg Ala Val Leu Ile Thr Gly Cys Asp Ser Gly Phe Gly Lys 
                85                  90                  95      


Glu Thr Ala Lys Lys Leu Asp Ser Met Gly Phe Thr Val Leu Ala Thr 
            100                 105                 110         


Val Leu Glu Leu Asn Ser Pro Gly Ala Ile Glu Leu Arg Thr Cys Cys 
        115                 120                 125             


Ser Pro Arg Leu Arg Leu Leu Gln Met Asp Leu Thr Lys Pro Gly Asp 
    130                 135                 140                 


Ile Ser Arg Val Leu Glu Phe Thr Lys Ala His Thr Thr Ser Thr Gly 
145                 150                 155                 160 


Leu Trp Gly Leu Val Asn Asn Ala Gly His Asn Glu Val Val Ala Asp 
                165                 170                 175     


Ala Glu Leu Ser Pro Val Ala Thr Phe Arg Ser Cys Met Glu Val Asn 
            180                 185                 190         


Phe Phe Gly Ala Leu Glu Leu Thr Lys Gly Leu Leu Pro Leu Leu Arg 
        195                 200                 205             


Ser Ser Arg Gly Arg Ile Val Thr Val Gly Ser Pro Ala Gly Asp Met 
    210                 215                 220                 


Pro Tyr Pro Cys Leu Gly Ala Tyr Gly Thr Ser Lys Ala Ala Val Ala 
225                 230                 235                 240 


Leu Leu Met Asp Thr Phe Ser Cys Glu Leu Leu Pro Trp Gly Val Lys 
                245                 250                 255     


Val Ser Ile Ile Gln Pro Gly Cys Phe Lys Thr Glu Ser Val Arg Asn 
            260                 265                 270         


Val Gly Gln Trp Glu Lys Arg Lys Gln Leu Leu Leu Ala Asn Leu Pro 
        275                 280                 285             


Gln Glu Leu Leu Gln Ala Tyr Gly Lys Asp Tyr Ile Glu His Leu His 
    290                 295                 300                 


Gly Gln Phe Leu His Ser Leu Arg Leu Ala Met Ser Asp Leu Thr Pro 
305                 310                 315                 320 


Val Val Asp Ala Ile Thr Asp Ala Leu Leu Ala Ala Arg Pro Arg Arg 
                325                 330                 335     


Arg Tyr Tyr Pro Gly Gln Gly Leu Gly Leu Met Tyr Phe Ile His Tyr 
            340                 345                 350         


Tyr Leu Pro Glu Gly Leu Arg Arg Arg Phe Leu Gln Ala Phe Phe Ile 
        355                 360                 365             


Ser His Cys Leu Pro Arg Ala Leu Gln Pro Gly Gln Pro Gly Thr Thr 
    370                 375                 380                 


Pro Pro Gln Asp Ala Ala Gln Asp Pro Asn Leu Ser Pro Gly Pro Ser 
385                 390                 395                 400 


Pro Ala Val Ala Arg 
                405 


<210>  3
<211>  1477
<212>  DNA
<213>  Homo sapiens

<400>  3
gggaaattgg ctagcactgc ctgagactac tccagcctcc cccgtccctg atgtcacaat     60

tcagaggctg ctgcctgctt aggaggttgt agaaagctct gtaggttctc tctgtgtgtc    120

ctacaggagt cttcaggcca gctccctgtc ggatggcttt tatgaaaaaa tatctcctcc    180

ccattctggg gctcttcatg gcctactact actattctgc aaacgaggaa ttcagaccag    240

agatgctcca aggaaagaaa gtgattgtca caggggccag caaagggatc ggaagagaga    300

tggcttatca tctggcgaag atgggagccc atgtggtggt gacagcgagg tcaaaagaaa    360

ctctacagaa ggtggtatcc cactgcctgg agcttggagc agcctcagca cactacattg    420

ctggcaccat ggaagacatg accttcgcag agcaatttgt tgcccaagca ggaaagctca    480

tgggaggact agacatgctc attctcaacc acatcaccaa cacttctttg aatctttttc    540

atgatgatat tcaccatgtg cgcaaaagca tggaagtcaa cttcctcagt tacgtggtcc    600

tgactgtagc tgccttgccc atgctgaagc agagcaatgg aagcattgtt gtcgtctcct    660

ctctggctgg gaaagtggct tatccaatgg ttgctgccta ttctgcaagc aagtttgctt    720

tggatgggtt cttctcctcc atcagaaagg aatattcagt gtccagggtc aatgtatcaa    780

tcactctctg tgttcttggc ctcatagaca cagaaacagc catgaaggca gtttctggga    840

tagtccatat gcaagcagct ccaaaggagg aatgtgccct ggagatcatc aaagggggag    900

ctctgcgcca agaagaagtg tattatgaca gctcactctg gaccactctt ctgatcagaa    960

atccatgcag gaagatcctg gaatttctct actcaacgag ctataatatg gacagattca   1020

taaacaagta ggaactccct gagggctggg catgctgagg gattttggga ctgttctgtc   1080

tcatgtttat ctgagctctt atctatgaag acatcttccc agagtgtccc cagagacatg   1140

caagtcatgg gtcacacctg acaaatggaa ggagttcctc taacatttgc aaaatggaaa   1200

tgtaataata atgaatgtca tgcaccgctg cagccagcag ttgtaaaatt gttagtaaac   1260

ataggtataa ttaccagata gttatattaa atttatatct tatatataat aatatgtgat   1320

gattaataca atattaatta taataaaggt cacataaact ttataaattc ataactggta   1380

gctataactt gagcttattc aggatggttt ctttaaaacc ataaactgta caaatgaaat   1440

ttttcaatat ttgtttctta aaaaaaaaaa aaaaaaa                            1477


<210>  4
<211>  1939
<212>  DNA
<213>  Homo sapiens

<400>  4
ccctctcgcg ccccaggccg gtgtaccccc gcactccgcg ccccggccta gaagctctct     60

ctccccgctc cccggcccgg cccccgcccc gccccgcccc agcccgctgg gccgccatgg    120

agcgctggcc ttggccgtcg ggcggcgcct ggctgctcgt ggctgcccgc gcgctgctgc    180

agctgctgcg ctcagacctg cgtctgggcc gcccgctgct ggcggcgctg gcgctgctgg    240

ccgcgctcga ctggctgtgc cagcgcctgc tgcccccgcc ggccgcactc gccgtgctgg    300

ccgccgccgg ctggatcgcg ttgtcccgcc tggcgcgccc gcagcgcctg ccggtggcca    360

ctcgcgcggt gctcatcacc ggctgtgact ctggttttgg caaggagacg gccaagaaac    420

tggactccat gggcttcacg gtgctggcca ccgtattgga gttgaacagc cccggtgcca    480

tcgagctgcg tacctgctgc tcccctcgcc taaggctgct gcagatggac ctgaccaaac    540

caggagacat tagccgcgtg ctagagttca ccaaggccca caccaccagc accggcctgt    600

ggggcctcgt caacaacgca ggccacaatg aagtagttgc tgatgcggag ctgtctccag    660

tggccacttt ccgtagctgc atggaggtga atttctttgg cgcgctcgag ctgaccaagg    720

gcctcctgcc cctgctgcgc agctcaaggg gccgcatcgt gactgtgggg agcccagcgg    780

gggacatgcc atatccgtgc ttgggggcct atggaacctc caaagcggcc gtggcgctac    840

tcatggacac attcagctgt gaactccttc cctggggggt caaggtcagc atcatccagc    900

ctggctgctt caagacagag tcagtgagaa acgtgggtca gtgggaaaag cgcaagcaat    960

tgctgctggc caacctgcct caagagctgc tgcaggccta cggcaaggac tacatcgagc   1020

acttgcatgg gcagttcctg cactcgctac gcctggccat gtccgacctc accccagttg   1080

tagatgccat cacagatgcg ctgctggcag ctcggccccg ccgccgctat taccccggcc   1140

agggcctggg gctcatgtac ttcatccact actacctgcc tgaaggcctg cggcgccgct   1200

tcctgcaggc cttcttcatc agtcactgtc tgcctcgagc actgcagcct ggccagcctg   1260

gcactacccc accacaggac gcagcccagg acccaaacct gagccccggc ccttccccag   1320

cagtggctcg gtgagccatg tgcacctatg gcccagccac tgcagcacag gaggctccgt   1380

gagcccttgg ttcctccccg aaaaccccca gcattacgat cccccaagtg tcctggaccc   1440

tggcctaaag aatcccaccc ccacttcatg cccactgccg atgcccaatc caggcccggt   1500

gaggccaagg tttcccagtg agcctctgcg cctctccact gtttcatgag cccaaacacc   1560

ctcctggcac aacgctctac cctgcagctt ggagaactcc gctggatggg gagtctcatg   1620

caagacttca ctgcagcctt tcacaggact ctgcagatag tgcctctgca aactaaggag   1680

tgactaggtg ggttggggac cccctcagga ttgtttctcg gcaccagtgc ctcagtgctg   1740

caattgaggg ctaaatccca agtgtctctt gactggctca agaattaggg ccccaactac   1800

acacccccaa gccacaggga agcatgtact gtacttccca attgccacat tttaaataaa   1860

gacaaatttt tatttcttct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1920

aaaaaaaaaa aaaaaaaaa                                                1939


<210>  5
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  5
gcatacgggt cctggcatct tgtcc                                           25


<210>  6
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  6
atggtgatct tcttgctggt cttgc                                           25


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  7
gacagcgagg tcaaaagaaa                                                 20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  8
gtcctcccat gagctttcct g                                               21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  9
ccaccgtatt ggagttgaac a                                               21


<210>  10
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  10
cgcggctaat gtctcctgg                                                  19


<210>  11
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
cacaggggtc ttagtcgtga c                                               21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
ccaggtgaat gaacccacac a                                               21


<210>  13
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  13
actggcgagc gtcatcttc                                                  19


<210>  14
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  14
tcctcgttat aggtggagtc ttg                                             23


<210>  15
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  15
gcagagcaca aggatcagtt c                                               21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  16
ggcagctact gttgatgttg c                                               21


