﻿               SEQUENCE LISTING

<110> Ruprecht-Karl Universität Heidelberg

<120> Monoclonal antibodies for the treatment of Osteoporosis, Multiple Sclerosis and neoplastic diseases

<130> 141221EP

<160> 21

<170> BiSSAP 1.2

<210> 1
<211> 2135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Plexin-B1

<400> 1
Met Pro Ala Leu Gly Pro Ala Leu Leu Gln Ala Leu Trp Ala Gly Trp 
1               5                   10                  15      
Val Leu Thr Leu Gln Pro Leu Pro Pro Thr Ala Phe Thr Pro Asn Gly 
            20                  25                  30          
Thr Tyr Leu Gln His Leu Ala Arg Asp Pro Thr Ser Gly Thr Leu Tyr 
        35                  40                  45              
Leu Gly Ala Thr Asn Phe Leu Phe Gln Leu Ser Pro Gly Leu Gln Leu 
    50                  55                  60                  
Glu Ala Thr Val Ser Thr Gly Pro Val Leu Asp Ser Arg Asp Cys Leu 
65                  70                  75                  80  
Pro Pro Val Met Pro Asp Glu Cys Pro Gln Ala Gln Pro Thr Asn Asn 
                85                  90                  95      
Pro Asn Gln Leu Leu Leu Val Ser Pro Gly Ala Leu Val Val Cys Gly 
            100                 105                 110         
Ser Val His Gln Gly Val Cys Glu Gln Arg Arg Leu Gly Gln Leu Glu 
        115                 120                 125             
Gln Leu Leu Leu Arg Pro Glu Arg Pro Gly Asp Thr Gln Tyr Val Ala 
    130                 135                 140                 
Ala Asn Asp Pro Ala Val Ser Thr Val Gly Leu Val Ala Gln Gly Leu 
145                 150                 155                 160 
Ala Gly Glu Pro Leu Leu Phe Val Gly Arg Gly Tyr Thr Ser Arg Gly 
                165                 170                 175     
Val Gly Gly Gly Ile Pro Pro Ile Thr Thr Arg Ala Leu Trp Pro Pro 
            180                 185                 190         
Asp Pro Gln Ala Ala Phe Ser Tyr Glu Glu Thr Ala Lys Leu Ala Val 
        195                 200                 205             
Gly Arg Leu Ser Glu Tyr Ser His His Phe Val Ser Ala Phe Ala Arg 
    210                 215                 220                 
Gly Ala Ser Ala Tyr Phe Leu Phe Leu Arg Arg Asp Leu Gln Ala Gln 
225                 230                 235                 240 
Ser Arg Ala Phe Arg Ala Tyr Val Ser Arg Val Cys Leu Arg Asp Gln 
                245                 250                 255     
His Tyr Tyr Ser Tyr Val Glu Leu Pro Leu Ala Cys Glu Gly Gly Arg 
            260                 265                 270         
Tyr Gly Leu Ile Gln Ala Ala Ala Val Ala Thr Ser Arg Glu Val Ala 
        275                 280                 285             
His Gly Glu Val Leu Phe Ala Ala Phe Ser Ser Ala Ala Pro Pro Thr 
    290                 295                 300                 
Val Gly Arg Pro Pro Ser Ala Ala Ala Gly Ala Ser Gly Ala Ser Ala 
305                 310                 315                 320 
Leu Cys Ala Phe Pro Leu Asp Glu Val Asp Arg Leu Ala Asn Arg Thr 
                325                 330                 335     
Arg Asp Ala Cys Tyr Thr Arg Glu Gly Arg Ala Glu Asp Gly Thr Glu 
            340                 345                 350         
Val Ala Tyr Ile Glu Tyr Asp Val Asn Ser Asp Cys Ala Gln Leu Pro 
        355                 360                 365             
Val Asp Thr Leu Asp Ala Tyr Pro Cys Gly Ser Asp His Thr Pro Ser 
    370                 375                 380                 
Pro Met Ala Ser Arg Val Pro Leu Glu Ala Thr Pro Ile Leu Glu Trp 
385                 390                 395                 400 
Pro Gly Ile Gln Leu Thr Ala Val Ala Val Thr Met Glu Asp Gly His 
                405                 410                 415     
Thr Ile Ala Phe Leu Gly Asp Ser Gln Gly Gln Leu His Arg Val Tyr 
            420                 425                 430         
Leu Gly Pro Gly Ser Asp Gly His Pro Tyr Ser Thr Gln Ser Ile Gln 
        435                 440                 445             
Gln Gly Ser Ala Val Ser Arg Asp Leu Thr Phe Asp Gly Thr Phe Glu 
    450                 455                 460                 
His Leu Tyr Val Met Thr Gln Ser Thr Leu Leu Lys Val Pro Val Ala 
465                 470                 475                 480 
Ser Cys Ala Gln His Leu Asp Cys Ala Ser Cys Leu Ala His Arg Asp 
                485                 490                 495     
Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            500                 505                 510         
Glu Cys Ser Arg Gly Gln Gly Pro Glu Gln Trp Leu Trp Ser Phe Gln 
        515                 520                 525             
Pro Glu Leu Gly Cys Leu Gln Val Ala Ala Met Ser Pro Ala Asn Ile 
    530                 535                 540                 
Ser Arg Glu Glu Thr Arg Glu Val Phe Leu Ser Val Pro Asp Leu Pro 
545                 550                 555                 560 
Pro Leu Trp Pro Gly Glu Ser Tyr Ser Cys His Phe Gly Glu His Gln 
                565                 570                 575     
Ser Pro Ala Leu Leu Thr Gly Ser Gly Val Met Cys Pro Ser Pro Asp 
            580                 585                 590         
Pro Ser Glu Ala Pro Val Leu Pro Arg Gly Ala Asp Tyr Val Ser Val 
        595                 600                 605             
Ser Val Glu Leu Arg Phe Gly Ala Val Val Ile Ala Lys Thr Ser Leu 
    610                 615                 620                 
Ser Phe Tyr Asp Cys Val Ala Val Thr Glu Leu Arg Pro Ser Ala Gln 
625                 630                 635                 640 
Cys Gln Ala Cys Val Ser Ser Arg Trp Gly Cys Asn Trp Cys Val Trp 
                645                 650                 655     
Gln His Leu Cys Thr His Lys Ala Ser Cys Asp Ala Gly Pro Met Val 
            660                 665                 670         
Ala Ser His Gln Ser Pro Leu Val Ser Pro Asp Pro Pro Ala Arg Gly 
        675                 680                 685             
Gly Pro Ser Pro Ser Pro Pro Thr Ala Pro Lys Ala Leu Ala Thr Pro 
    690                 695                 700                 
Ala Pro Asp Thr Leu Pro Val Glu Pro Gly Ala Pro Ser Thr Ala Thr 
705                 710                 715                 720 
Ala Ser Asp Ile Ser Pro Gly Ala Ser Pro Ser Leu Leu Ser Pro Trp 
                725                 730                 735     
Gly Pro Trp Ala Gly Ser Gly Ser Ile Ser Ser Pro Gly Ser Thr Gly 
            740                 745                 750         
Ser Pro Leu His Glu Glu Pro Ser Pro Pro Ser Pro Gln Asn Gly Pro 
        755                 760                 765             
Gly Thr Ala Val Pro Ala Pro Thr Asp Phe Arg Pro Ser Ala Thr Pro 
    770                 775                 780                 
Glu Asp Leu Leu Ala Ser Pro Leu Ser Pro Ser Glu Val Ala Ala Val 
785                 790                 795                 800 
Pro Pro Ala Asp Pro Gly Pro Glu Ala Leu His Pro Thr Val Pro Leu 
                805                 810                 815     
Asp Leu Pro Pro Ala Thr Val Pro Ala Thr Thr Phe Pro Gly Ala Met 
            820                 825                 830         
Gly Ser Val Lys Pro Ala Leu Asp Trp Leu Thr Arg Glu Gly Gly Glu 
        835                 840                 845             
Leu Pro Glu Ala Asp Glu Trp Thr Gly Gly Asp Ala Pro Ala Phe Ser 
    850                 855                 860                 
Thr Ser Thr Leu Leu Ser Gly Asp Gly Asp Ser Ala Glu Leu Glu Gly 
865                 870                 875                 880 
Pro Pro Ala Pro Leu Ile Leu Pro Ser Ser Leu Asp Tyr Gln Tyr Asp 
                885                 890                 895     
Thr Pro Gly Leu Trp Glu Leu Glu Glu Ala Thr Leu Gly Ala Ser Ser 
            900                 905                 910         
Cys Pro Cys Val Glu Ser Val Gln Gly Ser Thr Leu Met Pro Val His 
        915                 920                 925             
Val Glu Arg Glu Ile Arg Leu Leu Gly Arg Asn Leu His Leu Phe Gln 
    930                 935                 940                 
Asp Gly Pro Gly Asp Asn Glu Cys Val Met Glu Leu Glu Gly Leu Glu 
945                 950                 955                 960 
Val Val Val Glu Ala Arg Val Glu Cys Glu Pro Pro Pro Asp Thr Gln 
                965                 970                 975     
Cys His Val Thr Cys Gln Gln His Gln Leu Ser Tyr Glu Ala Leu Gln 
            980                 985                 990         
Pro Glu Leu Arg Val Gly Leu Phe Leu Arg Arg Ala Gly Arg Leu Arg 
        995                 1000                1005            
Val Asp Ser Ala Glu Gly Leu His Val Val Leu Tyr Asp Cys Ser Val 
    1010                1015                1020                
Gly His Gly Asp Cys Ser Arg Cys Gln Thr Ala Met Pro Gln Tyr Gly 
1025                1030                1035                1040
Cys Val Trp Cys Glu Gly Glu Arg Pro Arg Cys Val Thr Arg Glu Ala 
                1045                1050                1055    
Cys Gly Glu Ala Glu Ala Val Ala Thr Gln Cys Pro Ala Pro Leu Ile 
            1060                1065                1070        
His Ser Val Glu Pro Leu Thr Gly Pro Val Asp Gly Gly Thr Arg Val 
        1075                1080                1085            
Thr Ile Arg Gly Ser Asn Leu Gly Gln His Val Gln Asp Val Leu Gly 
    1090                1095                1100                
Met Val Thr Val Ala Gly Val Pro Cys Ala Val Asp Ala Gln Glu Tyr 
1105                1110                1115                1120
Glu Val Ser Ser Ser Leu Val Cys Ile Thr Gly Ala Ser Gly Glu Glu 
                1125                1130                1135    
Val Ala Gly Ala Thr Ala Val Glu Val Pro Gly Arg Gly Arg Gly Val 
            1140                1145                1150        
Ser Glu His Asp Phe Ala Tyr Gln Asp Pro Lys Val His Ser Ile Phe 
        1155                1160                1165            
Pro Ala Arg Gly Pro Arg Ala Gly Gly Thr Arg Leu Thr Leu Asn Gly 
    1170                1175                1180                
Ser Lys Leu Leu Thr Gly Arg Leu Glu Asp Ile Arg Val Val Val Gly 
1185                1190                1195                1200
Asp Gln Pro Cys His Leu Leu Pro Glu Gln Gln Ser Glu Gln Leu Arg 
                1205                1210                1215    
Cys Glu Thr Ser Pro Arg Pro Thr Pro Ala Thr Leu Pro Val Ala Val 
            1220                1225                1230        
Trp Phe Gly Ala Thr Glu Arg Arg Leu Gln Arg Gly Gln Phe Lys Tyr 
        1235                1240                1245            
Thr Leu Asp Pro Asn Ile Thr Ser Ala Gly Pro Thr Lys Ser Phe Leu 
    1250                1255                1260                
Ser Gly Gly Arg Glu Ile Cys Val Arg Gly Gln Asn Leu Asp Val Val 
1265                1270                1275                1280
Gln Thr Pro Arg Ile Arg Val Thr Val Val Ser Arg Met Leu Gln Pro 
                1285                1290                1295    
Ser Gln Gly Leu Gly Arg Arg Arg Arg Val Val Pro Glu Thr Ala Cys 
            1300                1305                1310        
Ser Leu Gly Pro Ser Cys Ser Ser Gln Gln Phe Glu Glu Pro Cys His 
        1315                1320                1325            
Val Asn Ser Ser Gln Leu Ile Thr Cys Arg Thr Pro Ala Leu Pro Gly 
    1330                1335                1340                
Leu Pro Glu Asp Pro Trp Val Arg Val Glu Phe Ile Leu Asp Asn Leu 
1345                1350                1355                1360
Val Phe Asp Phe Ala Thr Leu Asn Pro Thr Pro Phe Ser Tyr Glu Ala 
                1365                1370                1375    
Asp Pro Thr Leu Gln Pro Leu Asn Pro Glu Asp Pro Thr Met Pro Phe 
            1380                1385                1390        
Arg His Lys Pro Gly Ser Val Phe Ser Val Glu Gly Glu Asn Leu Asp 
        1395                1400                1405            
Leu Ala Met Ser Lys Glu Glu Val Val Ala Met Ile Gly Asp Gly Pro 
    1410                1415                1420                
Cys Val Val Lys Thr Leu Thr Arg His His Leu Tyr Cys Glu Pro Pro 
1425                1430                1435                1440
Val Glu Gln Pro Leu Pro Arg His His Ala Leu Arg Glu Ala Pro Asp 
                1445                1450                1455    
Ser Leu Pro Glu Phe Thr Val Gln Met Gly Asn Leu Arg Phe Ser Leu 
            1460                1465                1470        
Gly His Val Gln Tyr Asp Gly Glu Ser Pro Gly Ala Phe Pro Val Ala 
        1475                1480                1485            
Ala Gln Val Gly Leu Gly Val Gly Thr Ser Leu Leu Ala Leu Gly Val 
    1490                1495                1500                
Ile Ile Ile Val Leu Met Tyr Arg Arg Lys Ser Lys Gln Ala Leu Arg 
1505                1510                1515                1520
Asp Tyr Lys Lys Val Gln Ile Gln Leu Glu Asn Leu Glu Ser Ser Val 
                1525                1530                1535    
Arg Asp Arg Cys Lys Lys Glu Phe Thr Asp Leu Met Thr Glu Met Thr 
            1540                1545                1550        
Asp Leu Thr Ser Asp Leu Leu Gly Ser Gly Ile Pro Phe Leu Asp Tyr 
        1555                1560                1565            
Lys Val Tyr Ala Glu Arg Ile Phe Phe Pro Gly His Arg Glu Ser Pro 
    1570                1575                1580                
Leu His Arg Asp Leu Gly Val Pro Glu Ser Arg Arg Pro Thr Val Glu 
1585                1590                1595                1600
Gln Gly Leu Gly Gln Leu Ser Asn Leu Leu Asn Ser Lys Leu Phe Leu 
                1605                1610                1615    
Thr Lys Phe Ile His Thr Leu Glu Ser Gln Arg Thr Phe Ser Ala Arg 
            1620                1625                1630        
Asp Arg Ala Tyr Val Ala Ser Leu Leu Thr Val Ala Leu His Gly Lys 
        1635                1640                1645            
Leu Glu Tyr Phe Thr Asp Ile Leu Arg Thr Leu Leu Ser Asp Leu Val 
    1650                1655                1660                
Ala Gln Tyr Val Ala Lys Asn Pro Lys Leu Met Leu Arg Arg Thr Glu 
1665                1670                1675                1680
Thr Val Val Glu Lys Leu Leu Thr Asn Trp Met Ser Ile Cys Leu Tyr 
                1685                1690                1695    
Thr Phe Val Arg Asp Ser Val Gly Glu Pro Leu Tyr Met Leu Phe Arg 
            1700                1705                1710        
Gly Ile Lys His Gln Val Asp Lys Gly Pro Val Asp Ser Val Thr Gly 
        1715                1720                1725            
Lys Ala Lys Tyr Thr Leu Asn Asp Asn Arg Leu Leu Arg Glu Asp Val 
    1730                1735                1740                
Glu Tyr Arg Pro Leu Thr Leu Asn Ala Leu Leu Ala Val Gly Pro Gly 
1745                1750                1755                1760
Ala Gly Glu Ala Gln Gly Val Pro Val Lys Val Leu Asp Cys Asp Thr 
                1765                1770                1775    
Ile Ser Gln Ala Lys Glu Lys Met Leu Asp Gln Leu Tyr Lys Gly Val 
            1780                1785                1790        
Pro Leu Thr Gln Arg Pro Asp Pro Arg Thr Leu Asp Val Glu Trp Arg 
        1795                1800                1805            
Ser Gly Val Ala Gly His Leu Ile Leu Ser Asp Glu Asp Val Thr Ser 
    1810                1815                1820                
Glu Val Gln Gly Leu Trp Arg Arg Leu Asn Thr Leu Gln His Tyr Lys 
1825                1830                1835                1840
Val Pro Asp Gly Ala Thr Val Ala Leu Val Pro Cys Leu Thr Lys His 
                1845                1850                1855    
Val Leu Arg Glu Asn Gln Asp Tyr Val Pro Gly Glu Arg Thr Pro Met 
            1860                1865                1870        
Leu Glu Asp Val Asp Glu Gly Gly Ile Arg Pro Trp His Leu Val Lys 
        1875                1880                1885            
Pro Ser Asp Glu Pro Glu Pro Pro Arg Pro Arg Arg Gly Ser Leu Arg 
    1890                1895                1900                
Gly Gly Glu Arg Glu Arg Ala Lys Ala Ile Pro Glu Ile Tyr Leu Thr 
1905                1910                1915                1920
Arg Leu Leu Ser Met Lys Gly Thr Leu Gln Lys Phe Val Asp Asp Leu 
                1925                1930                1935    
Phe Gln Val Ile Leu Ser Thr Ser Arg Pro Val Pro Leu Ala Val Lys 
            1940                1945                1950        
Tyr Phe Phe Asp Leu Leu Asp Glu Gln Ala Gln Gln His Gly Ile Ser 
        1955                1960                1965            
Asp Gln Asp Thr Ile His Ile Trp Lys Thr Asn Ser Leu Pro Leu Arg 
    1970                1975                1980                
Phe Trp Ile Asn Ile Ile Lys Asn Pro Gln Phe Val Phe Asp Val Gln 
1985                1990                1995                2000
Thr Ser Asp Asn Met Asp Ala Val Leu Leu Val Ile Ala Gln Thr Phe 
                2005                2010                2015    
Met Asp Ala Cys Thr Leu Ala Asp His Lys Leu Gly Arg Asp Ser Pro 
            2020                2025                2030        
Ile Asn Lys Leu Leu Tyr Ala Arg Asp Ile Pro Arg Tyr Lys Arg Met 
        2035                2040                2045            
Val Glu Arg Tyr Tyr Ala Asp Ile Arg Gln Thr Val Pro Ala Ser Asp 
    2050                2055                2060                
Gln Glu Met Asn Ser Val Leu Ala Glu Leu Ser Trp Asn Tyr Ser Gly 
2065                2070                2075                2080
Asp Leu Gly Ala Arg Val Ala Leu His Glu Leu Tyr Lys Tyr Ile Asn 
                2085                2090                2095    
Lys Tyr Tyr Asp Gln Ile Ile Thr Ala Leu Glu Glu Asp Gly Thr Ala 
            2100                2105                2110        
Gln Lys Met Gln Leu Gly Tyr Arg Leu Gln Gln Ile Ala Ala Ala Val 
        2115                2120                2125            
Glu Asn Lys Val Thr Asp Leu 
    2130                2135

<210> 2
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..318
<223> /mol_type="unassigned DNA"
      /note="mAb #19 VL"
      /organism="Artificial Sequence"

<400> 2
gacccagact ccactcactt tgtcggttac cattggacaa ccagcctcta tctcttgcaa      60

gtcaagtcag agcctcttat atagtaatgg aaaaacctat ttgaattggt tattacagag     120

gccaggccag tctccaaagc gcctaatcta tctggtgtct aaactggact ctggagtccc     180

tgacaggttc actggcagtg gatcaggaac agattttaca ctgaaaatca gcagagtgga     240

ggctgaggat ttgggagttt attactgcgt gcaaggtaca cattttcctc acacgttcgg     300

aggggggacc aagctgg                                                    318


<210> 3
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #19 VL

<400> 3
Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala Ser 
1               5                   10                  15      
Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr 
            20                  25                  30          
Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu 
        35                  40                  45              
Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
65                  70                  75                  80  
Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly Thr His Phe Pro 
                85                  90                  95      
His Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105 

<210> 4
<211> 268
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..268
<223> /mol_type="unassigned DNA"
      /note="mAb #19 VH"
      /organism="Artificial Sequence"

<400> 4
tcctgcaagg ctactggcta cacattcagt agctactgga tagagtgggt aaagcagagg     60

cctggacatg gccttgagtg gattggagag attttacctg gaagtggtag tactaactac    120

aatgagaagt tcaagggcaa ggccacattc actgcagata catcctccaa cacagcctac    180

atgcaactca gcagcctgac atctgaggac tctgccgtct attactgtgt aagaaactat    240

ggttactggg gccaagggac tctggtca                                       268


<210> 5
<211> 89
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #19 VH

<400> 5
Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu Trp 
1               5                   10                  15      
Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu Ile Leu 
            20                  25                  30          
Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
        35                  40                  45              
Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser 
    50                  55                  60                  
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Arg Asn Tyr 
65                  70                  75                  80  
Gly Tyr Trp Gly Gln Gly Thr Leu Val 
                85                  

<210> 6
<211> 285
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..285
<223> /mol_type="unassigned DNA"
      /note="mAb #527 VL"
      /organism="Artificial Sequence"

<400> 6
gtcagcagga gagaaggtca ctatgagctg caaatccagt cagagtctgc tcaacagtag     60

aacccgaaag aactacttgg cttggtacca gcagaaacca gggcagtctc ctaaactgct    120

gatctactgg gcatccacta gggaatctgg ggtccctgat cgcttcacag gcagtggatc    180

tgggacagat ttcactctca ccatcagcag tgtgcaggct gaagacctgg cagtttatta    240

ctgcaagcaa tcttataatc tgtacacgtt cggagggggg accaa                    285


<210> 7
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #527 VL

<400> 7
Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu 
1               5                   10                  15      
Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
            20                  25                  30          
Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
        35                  40                  45              
Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
    50                  55                  60                  
Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
65                  70                  75                  80  
Cys Lys Gln Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys 
                85                  90                  95  

<210> 8
<211> 289
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..289
<223> /mol_type="unassigned DNA"
      /note="mAb #527 VH"
      /organism="Artificial Sequence"

<400> 8
gatgtcctgc aaggcttctg gctacacctt caccagctac tggataacct gggtgaagca     60

gaggcctgga caaggccttg agtggattgg agatatttat cctggtagtg gtagtactaa    120

ctacaatgag aagttcaaga gcaaggccac actgactgta gacacatcct ccagcacagc    180

ctacatgcag ctcagcagcc tgacatctga ggactctgcg gtctattact gtgcaagagc    240

gggatactac ggtagtagct cctggtttgc ttactggggc caagggacc                289


<210> 9
<211> 96
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #527 VH

<400> 9
Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Thr 
1               5                   10                  15      
Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile 
            20                  25                  30          
Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys Ser Lys 
        35                  40                  45              
Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu 
    50                  55                  60                  
Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ala 
65                  70                  75                  80  
Gly Tyr Tyr Gly Ser Ser Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
                85                  90                  95      



<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #19 VL CDR1

<400> 10
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #19 VL CDR2

<400> 11
Leu Val Ser Lys Leu Asp Ser 
1               5           

<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #19 VL CDR3

<400> 12
Val Gln Gly Thr His Phe Pro His Thr 
1               5                   

<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #19 VH CDR1

<400> 13
Ser Tyr Trp Ile Glu 
1               5   

<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #19 VH CDR2

<400> 14
Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 15
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #19 VH CDR3

<400> 15
Asn Tyr Gly Tyr 
1               

<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #527 VL CDR1

<400> 16
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #527 VL CDR2

<400> 17
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #527 VL CDR3

<400> 18
Lys Gln Ser Tyr Asn Leu Tyr Thr 
1               5               

<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #527 VH CDR1

<400> 19
Ser Tyr Trp Ile Thr 
1               5   

<210> 20
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #527 VH CDR2

<400> 20
Asp Ile Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Ser 
    

<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb #527 VH CDR3

<400> 21
Ala Gly Tyr Tyr Gly Ser Ser Ser Trp Phe Ala Tyr 
1               5                   10          

