                         SEQUENCE LISTING

<110>  Bavarian Nordic A/S
 
<120>  RECOMBINANT MODIFIED VACCINIA VIRUS ANKARA (MVA) FILOVIRUS 
       VACCINE

<130>  BN89PCT

<150>  US 62/045,538
<151>  2014-09-03

<150>  US 62/055,154
<151>  2014-09-25

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  2362
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence encoding GP-SEBOV-Maleo (GenBank Accession No. 
       U23069.1)

<400>  1
atttgatgaa gattaagcct gattaaggcc caaccttcat ctttttacca taatcttgtt       60

ctcaatacca tttaataggg gtatacttgc caaagcgccc ccatcttcag gatctcgcaa      120

tggagggtct tagcctactc caattgccca gagataaatt tcgaaaaagc tctttctttg      180

tttgggtcat catcttattt caaaaggcct tttccatgcc tttgggtgtt gtgaccaaca      240

gcactttaga agtaacagag attgaccagc tagtctgcaa ggatcatctt gcatcaactg      300

accagctgaa atcagttggt ctcaacctcg aggggagcgg agtatctact gatatcccat      360

ctgcgacaaa gcgttggggc ttcagatctg gtgtgcctcc ccaagtggtc agctatgaag      420

caggagaatg ggctgaaaat tgctacaatc ttgaaataaa gaaaccggac gggagcgaat      480

gcttaccccc accgccggat ggtgtcagag gctttccaag gtgccgctat gttcacaaag      540

cccaaggaac cgggccctgc ccgggtgact atgcctttca caaggatgga gctttcttcc      600

tctatgacag gctggcttca actgtaattt acagaggagt caattttgct gagggggtaa      660

tcgcattctt gatattggct aaaccaaagg aaacgttcct tcaatcaccc cccattcgag      720

aggcagcaaa ctacactgaa aatacatcaa gttactatgc cacatcctac ttggagtacg      780

aaatcgaaaa ttttggtgct caacactcca cgaccctttt caaaattaac aataatactt      840

ttgttcttct ggacaggccc cacacgcctc agttcctttt ccagctgaat gataccattc      900

aacttcacca acagttgagc aacacaactg ggaaactaat ttggacacta gatgctaata      960

tcaatgctga tattggtgaa tgggcttttt gggaaaataa aaaaatctct ccgaacaact     1020

acgtggagaa gagctgtctt tcgaaacttt atcgctcaac gagacagaag acgatgatgc     1080

gacatcgtcg agaactacaa agggaagaat ctccgaccgg gccaccagga agtattcgga     1140

cctggttcca aaggattccc ctgggatggt ttcattgcac gtaccagaag gggaaacaac     1200

attgccgtct cagaattcga cagaaggtcg aagagtagat gtgaatactc aggaaactat     1260

cacagagaca actgcaacaa tcataggcac taacggtaac aacatgcaga tctccaccat     1320

cgggacagga ctgagctcca gccaaatcct gagttcctca ccgaccatgg caccaagccc     1380

tgagactcag acctccacaa cctacacacc aaaactacca gtgatgacca ccgaggaacc     1440

aacaacacca ccgagaaact ctcctggctc aacaacagaa gcacccactc tcaccacccc     1500

agagaatata acaacagcgg ttaaaactgt ttgggcacaa gagtccacaa gcaacggtct     1560

aataacttca acagtaacag gtattcttgg gagccttgga cttcgaaaac gcagcagaag     1620

acaagttaac accagggcca cgggtaaatg caatcccaac ttacactact ggactgcaca     1680

agaacaacat aatgctgctg ggattgcctg gatcccgtac tttggaccgg gtgcagaagg     1740

catatacact gaaggcctta tgcacaacca aaatgcctta gtctgtggac tcagacaact     1800

tgcaaatgaa acaactcaag ctctgcagct tttcttaagg gccacgacgg agctgcggac     1860

atataccata ctcaatagga aggccataga tttccttctg cgacgatggg gcgggacatg     1920

taggatcctg ggaccagatt gttgcattga gccacatgat tggaccaaaa acatcactga     1980

taaaatcaac caaatcatcc atgatttcat cgacaaccct ttacccaatc aggataatga     2040

tgataattgg tggacgggct ggagacagtg gatccctgca ggaataggca ttactggaat     2100

tattattgca atcattgctc ttctttgcgt ctgcaagctg ctttgttgaa tatcaacttg     2160

aatcattaat ttaaagttga tacatttcta acattataaa ttataatctg atattaatac     2220

ttgaaaataa ggctaatgcc aaattctgtg ccaaacttga aagtaggttt accaaaatcc     2280

tttgaactgg aatgctttaa tgctctttct caatactata taagttcctt cccaaaataa     2340

tattgatgaa gattaagaaa aa                                              2362


<210>  2
<211>  676
<212>  PRT
<213>  SEBOV-MALEO

<400>  2

Met Glu Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Gln Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Ala Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Ala Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asn Asn Asn Thr 
225                 230                 235                 240 


Phe Val Leu Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile Gln Leu His Gln Gln Leu Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Leu Ser Glu Gln Leu Arg Gly Glu 
    290                 295                 300                 


Glu Leu Ser Phe Glu Thr Leu Ser Leu Asn Glu Thr Glu Asp Asp Asp 
305                 310                 315                 320 


Ala Thr Ser Ser Arg Thr Thr Lys Gly Arg Ile Ser Asp Arg Ala Thr 
                325                 330                 335     


Arg Lys Tyr Ser Asp Leu Val Pro Lys Asp Ser Pro Gly Met Val Ser 
            340                 345                 350         


Leu His Val Pro Glu Gly Glu Thr Thr Leu Pro Ser Gln Asn Ser Thr 
        355                 360                 365             


Glu Gly Arg Arg Val Asp Val Asn Thr Gln Glu Thr Ile Thr Glu Thr 
    370                 375                 380                 


Thr Ala Thr Ile Ile Gly Thr Asn Gly Asn Asn Met Gln Ile Ser Thr 
385                 390                 395                 400 


Ile Gly Thr Gly Leu Ser Ser Ser Gln Ile Leu Ser Ser Ser Pro Thr 
                405                 410                 415     


Met Ala Pro Ser Pro Glu Thr Gln Thr Ser Thr Thr Tyr Thr Pro Lys 
            420                 425                 430         


Leu Pro Val Met Thr Thr Glu Glu Pro Thr Thr Pro Pro Arg Asn Ser 
        435                 440                 445             


Pro Gly Ser Thr Thr Glu Ala Pro Thr Leu Thr Thr Pro Glu Asn Ile 
    450                 455                 460                 


Thr Thr Ala Val Lys Thr Val Trp Ala Gln Glu Ser Thr Ser Asn Gly 
465                 470                 475                 480 


Leu Ile Thr Ser Thr Val Thr Gly Ile Leu Gly Ser Leu Gly Leu Arg 
                485                 490                 495     


Lys Arg Ser Arg Arg Gln Val Asn Thr Arg Ala Thr Gly Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Ala Gln Glu Gln His Asn Ala Ala Gly 
        515                 520                 525             


Ile Ala Trp Ile Pro Tyr Phe Gly Pro Gly Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asn Ala Leu Val Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Tyr Thr Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Arg Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asn 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Ile Asp Asn Pro Leu Pro Asn Gln Asp Asn 
625                 630                 635                 640 


Asp Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Ile Ile Ile Ala Ile Ile Ala Leu Leu Cys Val Cys 
            660                 665                 670         


Lys Leu Leu Cys 
        675     


<210>  3
<211>  2926
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence encoding NP-SEBOV-Boniface (GenBank Accession No. 
       AF173836.1)

<400>  3
ctcaaactca aactaatatt gacattgaga ttgatctcat catttaccaa ttggagacaa       60

tttaactagt taatccccca tttgggggca ttcctaaagt gttgcgaagg tatgtgggtc      120

gtattgcttg gccttttcct aacctggctc ctcctacaat tctaaccttc ttgataagtg      180

tggttaccag agtaatagac taaatttgtc ctggtagtta gcattttcta gtaagaccga      240

tactatccca agtctcaaga gagggtgaga ggagggcccc gaggtatccc tttagtccac      300

aaaatctagc caattttagc taagtggact gattaccttc atcacacgct atctactaag      360

ggtttacctg agagcctaca acatggataa acgggtgaga ggttcatggg ccctgggagg      420

acaatctgag gttgatcttg actaccacaa gatattaaca gccgggcttt cagtccaaca      480

ggggattgtg cgacagagag tcatcccggt atatgtcgtg aatgatcttg agggtatttg      540

tcaacatatc attcaggctt ttgaagcagg tgtagatttc caggataatg ctgatagctt      600

ccttttactt ttatgtttac atcatgccta ccaaggagat cataggctct tcctcaaaag      660

tgatgcagtt caatatttag agggccatgg cttcaggttt gaggtccgag aaaaggagaa      720

tgtgcaccgt ctggatgaat tgttgcccaa tgttaccggt ggaaaaaatc tcaggagaac      780

attggctgct atgcccgaag aggagacaac ggaagctaat gctggtcagt ttctatcctt      840

tgccagtttg tttctaccca aacttgtcgt tggggagaaa gcgtgcctgg aaaaagtaca      900

aaggcaaatt caggtccatg cagaacaagg gctcattcaa tatccaactt cctggcaatc      960

agttggacac atgatggtga tcttccgttt gatgaggaca aactttttaa tcaagtttct     1020

actaatacat caagggatgc acatggttgc aggtcatgat gcgaatgaca cagtaatatc     1080

taattctgtt gcccaggcaa ggttctctgg tcttctgatt gtaaagactg ttctggatca     1140

catcctacaa aaaacagatc tcggagtacg acttcatcca ctggccagga cagcaaaagt     1200

gaagaatgag gtcagttcat tcaaggcggc tcttggttca cttgccaagc atggagaata     1260

tgctccgttt gcacgtctcc ttaatctttc tggagtcaac aacttggaac atgggcttta     1320

tccacaactt tcagccatcg ctttgggtgt tgcaactgcc cacgggagta cgcttgctgg     1380

tgtgaatgta ggggagcaat atcagcaact gcgtgaggct gctactgagg ctgaaaagca     1440

actccaacaa tatgctgaaa cacgtgagtt ggataacctt gggcttgatg aacaggagaa     1500

gaagattctc atgagcttcc accagaagaa gaatgagatc agcttccagc agactaatgc     1560

aatggtaacc ttaaggaaag aacggctggc taaattgacc gaagccatca cgactgcatc     1620

gaagatcaag gttggagacc gttatcctga tgacaatgat attccatttc ccgggccgat     1680

ctatgatgac actcacccca atccctctga tgacaatcct gatgattcac gtgatacaac     1740

tattccaggt ggtgttgttg acccgtatga tgatgagagt aataattatc ctgactacga     1800

ggattcggct gaaggcacca caggagatct tgatctcttc aatttggacg acgacgatga     1860

tgacagccga ccaggaccac cagacagggg gcagaacaag gagagggcgg cccggacata     1920

tggcctccaa gatccgacct tggacggagc gaaaaaggtg ccggagttga ccccaggttc     1980

ccatcaacca ggcaacctcc acatcaccaa gtcgggttca aacaccaacc aaccacaagg     2040

caatatgtca tctactctcc atagtatgac ccctatacag gaagaatcag agcccgatga     2100

tcaaaaagat aatgatgacg agagtctcac atcccttgac tctgaaggtg acgaagatgg     2160

tgagagcatc tctgaggaga acaccccaac tgtagctcca ccagcaccag tctacaaaga     2220

cactggagta gacactaatc agcagaatgg accaagcagt actgtagata gtcaaggttc     2280

tgaaagtgaa gctctcccaa tcaactctaa aaagagttcc gcactagaag aaacatatta     2340

tcatctccta aaaacacagg gtccatttga ggcaatcaat tattatcacc taatgagtga     2400

tgaacccatt gcttttagca ctgaaagtgg caaggaatat atctttccag actcccttga     2460

agaagcctac ccgccgtggt tgagtgagaa ggaggcctta gagaaggaaa atcgttatct     2520

ggtcattgat ggccagcaat tcctctggcc ggtaatgagc ctacgggaca agttccttgc     2580

cgttcttcaa catgactgag gacctatgat tggtggatct tgtttattcc gagcctgatt     2640

ataattgttc tgataattca agtataagca cctaccccga aatataaacc ctatcttagt     2700

tataaggaaa ttaaataaat aacctgtaag ttataggact acgaagagct gcttgtgtca     2760

atttatcatg ggttgatacc cgtaccgcaa gaatcattat ttagtagttt tggtcagctt     2820

ctgatatgta ccaataagaa aacattatag cattaaaaca taaggtatct ttcaatgagc     2880

ttaggaggat aatatcctga taaattctat agaacttaag attaag                    2926


<210>  4
<211>  738
<212>  PRT
<213>  SEBOV-Boniface

<400>  4

Met Asp Lys Arg Val Arg Gly Ser Trp Ala Leu Gly Gly Gln Ser Glu 
1               5                   10                  15      


Val Asp Leu Asp Tyr His Lys Ile Leu Thr Ala Gly Leu Ser Val Gln 
            20                  25                  30          


Gln Gly Ile Val Arg Gln Arg Val Ile Pro Val Tyr Val Val Asn Asp 
        35                  40                  45              


Leu Glu Gly Ile Cys Gln His Ile Ile Gln Ala Phe Glu Ala Gly Val 
    50                  55                  60                  


Asp Phe Gln Asp Asn Ala Asp Ser Phe Leu Leu Leu Leu Cys Leu His 
65                  70                  75                  80  


His Ala Tyr Gln Gly Asp His Arg Leu Phe Leu Lys Ser Asp Ala Val 
                85                  90                  95      


Gln Tyr Leu Glu Gly His Gly Phe Arg Phe Glu Val Arg Glu Lys Glu 
            100                 105                 110         


Asn Val His Arg Leu Asp Glu Leu Leu Pro Asn Val Thr Gly Gly Lys 
        115                 120                 125             


Asn Leu Arg Arg Thr Leu Ala Ala Met Pro Glu Glu Glu Thr Thr Glu 
    130                 135                 140                 


Ala Asn Ala Gly Gln Phe Leu Ser Phe Ala Ser Leu Phe Leu Pro Lys 
145                 150                 155                 160 


Leu Val Val Gly Glu Lys Ala Cys Leu Glu Lys Val Gln Arg Gln Ile 
                165                 170                 175     


Gln Val His Ala Glu Gln Gly Leu Ile Gln Tyr Pro Thr Ser Trp Gln 
            180                 185                 190         


Ser Val Gly His Met Met Val Ile Phe Arg Leu Met Arg Thr Asn Phe 
        195                 200                 205             


Leu Ile Lys Phe Leu Leu Ile His Gln Gly Met His Met Val Ala Gly 
    210                 215                 220                 


His Asp Ala Asn Asp Thr Val Ile Ser Asn Ser Val Ala Gln Ala Arg 
225                 230                 235                 240 


Phe Ser Gly Leu Leu Ile Val Lys Thr Val Leu Asp His Ile Leu Gln 
                245                 250                 255     


Lys Thr Asp Leu Gly Val Arg Leu His Pro Leu Ala Arg Thr Ala Lys 
            260                 265                 270         


Val Lys Asn Glu Val Ser Ser Phe Lys Ala Ala Leu Gly Ser Leu Ala 
        275                 280                 285             


Lys His Gly Glu Tyr Ala Pro Phe Ala Arg Leu Leu Asn Leu Ser Gly 
    290                 295                 300                 


Val Asn Asn Leu Glu His Gly Leu Tyr Pro Gln Leu Ser Ala Ile Ala 
305                 310                 315                 320 


Leu Gly Val Ala Thr Ala His Gly Ser Thr Leu Ala Gly Val Asn Val 
                325                 330                 335     


Gly Glu Gln Tyr Gln Gln Leu Arg Glu Ala Ala Thr Glu Ala Glu Lys 
            340                 345                 350         


Gln Leu Gln Gln Tyr Ala Glu Thr Arg Glu Leu Asp Asn Leu Gly Leu 
        355                 360                 365             


Asp Glu Gln Glu Lys Lys Ile Leu Met Ser Phe His Gln Lys Lys Asn 
    370                 375                 380                 


Glu Ile Ser Phe Gln Gln Thr Asn Ala Met Val Thr Leu Arg Lys Glu 
385                 390                 395                 400 


Arg Leu Ala Lys Leu Thr Glu Ala Ile Thr Thr Ala Ser Lys Ile Lys 
                405                 410                 415     


Val Gly Asp Arg Tyr Pro Asp Asp Asn Asp Ile Pro Phe Pro Gly Pro 
            420                 425                 430         


Ile Tyr Asp Asp Thr His Pro Asn Pro Ser Asp Asp Asn Pro Asp Asp 
        435                 440                 445             


Ser Arg Asp Thr Thr Ile Pro Gly Gly Val Val Asp Pro Tyr Asp Asp 
    450                 455                 460                 


Glu Ser Asn Asn Tyr Pro Asp Tyr Glu Asp Ser Ala Glu Gly Thr Thr 
465                 470                 475                 480 


Gly Asp Leu Asp Leu Phe Asn Leu Asp Asp Asp Asp Asp Asp Ser Arg 
                485                 490                 495     


Pro Gly Pro Pro Asp Arg Gly Gln Asn Lys Glu Arg Ala Ala Arg Thr 
            500                 505                 510         


Tyr Gly Leu Gln Asp Pro Thr Leu Asp Gly Ala Lys Lys Val Pro Glu 
        515                 520                 525             


Leu Thr Pro Gly Ser His Gln Pro Gly Asn Leu His Ile Thr Lys Ser 
    530                 535                 540                 


Gly Ser Asn Thr Asn Gln Pro Gln Gly Asn Met Ser Ser Thr Leu His 
545                 550                 555                 560 


Ser Met Thr Pro Ile Gln Glu Glu Ser Glu Pro Asp Asp Gln Lys Asp 
                565                 570                 575     


Asn Asp Asp Glu Ser Leu Thr Ser Leu Asp Ser Glu Gly Asp Glu Asp 
            580                 585                 590         


Gly Glu Ser Ile Ser Glu Glu Asn Thr Pro Thr Val Ala Pro Pro Ala 
        595                 600                 605             


Pro Val Tyr Lys Asp Thr Gly Val Asp Thr Asn Gln Gln Asn Gly Pro 
    610                 615                 620                 


Ser Ser Thr Val Asp Ser Gln Gly Ser Glu Ser Glu Ala Leu Pro Ile 
625                 630                 635                 640 


Asn Ser Lys Lys Ser Ser Ala Leu Glu Glu Thr Tyr Tyr His Leu Leu 
                645                 650                 655     


Lys Thr Gln Gly Pro Phe Glu Ala Ile Asn Tyr Tyr His Leu Met Ser 
            660                 665                 670         


Asp Glu Pro Ile Ala Phe Ser Thr Glu Ser Gly Lys Glu Tyr Ile Phe 
        675                 680                 685             


Pro Asp Ser Leu Glu Glu Ala Tyr Pro Pro Trp Leu Ser Glu Lys Glu 
    690                 695                 700                 


Ala Leu Glu Lys Glu Asn Arg Tyr Leu Val Ile Asp Gly Gln Gln Phe 
705                 710                 715                 720 


Leu Trp Pro Val Met Ser Leu Arg Asp Lys Phe Leu Ala Val Leu Gln 
                725                 730                 735     


His Asp 
        


<210>  5
<211>  2046
<212>  DNA
<213>  Artificial sequence

<220>
<223>  codon-optimized DNA sequence encoding GP-MARV-Musoke (GenBank 
       Accession No. ABA87127.1 for protein sequence)

<400>  5
atgaaaacaa cctgcttcct gatcagcctg atcctgatcc agggcaccaa gaacctgccc       60

atcctggaaa tcgccagcaa caaccagccc cagaacgtgg atagcgtgtg cagcggcacc      120

ctgcagaaaa ccgaggacgt gcacctgatg ggcttcacac tgagcggcca gaaggtggcc      180

gatagccccc tggaagccag caagcgctgg gccttcagaa caggggtgcc acctaagaac      240

gtggagtaca cagagggcga ggaagccaag acctgctaca acatcagcgt gaccgacccc      300

agcggcaagt ccctgctgct ggacccccct accaacatca gagactaccc taagtgcaag      360

accatccacc acatccaggg ccagaatcct cacgctcagg gcattgctct gcacctgtgg      420

ggcgcattct tcctgtatga cagaatcgcc tccaccacca tgtaccgggg caaggtgttc      480

acagagggca atatcgccgc catgatcgtg aacaagaccg tgcacaagat gatcttcagc      540

agacagggcc agggctaccg gcacatgaac ctgaccagca ccaacaagta ctggaccagc      600

agcaacggca cccagaccaa cgacaccggc tgctttggcg ccctgcagga atacaacagc      660

accaagaatc agacctgcgc ccccagcaag atccctcctc ccctgcctac cgccagaccc      720

gagatcaagc tgacaagcac ccccaccgac gccaccaagc tgaacaccac cgacccctcc      780

agcgacgatg aggacctggc aactagtggt agcggcagcg gagagagaga gccccacacc      840

acctccgatg ccgtgaccaa gcagggcctg agcagcacaa tgccccctac ccccagccct      900

cagcctagca caccccagca gggcggcaat aacaccaacc actcccagga cgccgtgacc      960

gagctggaca agaacaatac caccgcccag cctagcatgc ccccccacaa cactactacc     1020

atctccacca acaataccag caagcacaac ttcagcaccc tgagcgcccc tctgcagaac     1080

accaccaacg acaacaccca gagcaccatc acagagaacg agcagaccag cgccccttcc     1140

atcaccaccc tgccccccac cggcaatcct accaccgcca agagcaccag ctccaagaag     1200

ggtcctgcaa ctaccgcccc caacacaacc aacgagcact tcaccagccc tcccccaacc     1260

cctagctcca cagcccagca cctggtgtac ttccggcgga agcggtccat cctgtggcgg     1320

gagggcgaca tgttcccctt tctggacggc ctgattaacg cccccatcga cttcgacccc     1380

gtgcccaata ccaagaccat cttcgacgag agtagttcat caggtgcatc agccgaagag     1440

gatcagcacg ccagccccaa catctccctg accctgagct acttccccaa catcaatgag     1500

aacaccgcct acagcggcga gaacgagaac gactgcgacg ccgagctgag aatttggagc     1560

gtgcaggaag atgacctggc cgctggcctg agttggatac cattcttcgg cccaggcatc     1620

gagggtctgt acaccgccgt gctgatcaag aaccagaaca acctcgtgtg cagactgcgg     1680

agactggcca accagaccgc caagtccctg gaactgctgc tgagagtgac caccgaagag     1740

agaaccttct ccctgatcaa ccggcacgcc attgattttc tgctgacccg ctggggcgga     1800

acatgcaagg tcctgggtcc agactgttgt atcggcatcg aggacctcag caagaacatc     1860

agcgaacaga ttgaccagat caagaaggac gagcagaaag agggcacagg ctggggcctg     1920

ggcggcaagt ggtggaccag cgactggggc gtgctgacaa acctgggcat cctgctgctg     1980

ctgtctatcg ctgtgctgat tgccctgagc tgcatctgtc ggatcttcac caagtacatc     2040

ggctga                                                                2046


<210>  6
<211>  681
<212>  PRT
<213>  MARV-Musoke

<400>  6

Met Lys Thr Thr Cys Phe Leu Ile Ser Leu Ile Leu Ile Gln Gly Thr 
1               5                   10                  15      


Lys Asn Leu Pro Ile Leu Glu Ile Ala Ser Asn Asn Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ala Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Ile Pro Pro Pro Leu Pro Thr Ala Arg Pro 
225                 230                 235                 240 


Glu Ile Lys Leu Thr Ser Thr Pro Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Ser Ser Asp Asp Glu Asp Leu Ala Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Arg Glu Pro His Thr Thr Ser Asp Ala Val Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Asp Ala Val Thr 
305                 310                 315                 320 


Glu Leu Asp Lys Asn Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Phe Ser 
            340                 345                 350         


Thr Leu Ser Ala Pro Leu Gln Asn Thr Thr Asn Asp Asn Thr Gln Ser 
        355                 360                 365             


Thr Ile Thr Glu Asn Glu Gln Thr Ser Ala Pro Ser Ile Thr Thr Leu 
    370                 375                 380                 


Pro Pro Thr Gly Asn Pro Thr Thr Ala Lys Ser Thr Ser Ser Lys Lys 
385                 390                 395                 400 


Gly Pro Ala Thr Thr Ala Pro Asn Thr Thr Asn Glu His Phe Thr Ser 
                405                 410                 415     


Pro Pro Pro Thr Pro Ser Ser Thr Ala Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Ser Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Pro Asn Ile Ser Leu Thr Leu Ser Tyr Phe Pro 
                485                 490                 495     


Asn Ile Asn Glu Asn Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Val Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  7
<211>  3642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence encoding TTC

<400>  7
atggagaccg acaccctgct gctgtgggtc ctgctcctgt gggtgcccgg cagcaccggc       60

gacgaagtga agcaggaaaa ccggctgctg aacgagagcg agagcagcag ccagggcctg      120

ctgggctact acttcagcga cctgaacttc caggccccca tggtggtgac cagcagcacc      180

accggcgacc tgagcatccc cagcagcgag ctggaaaaca tccccagcga gaaccagtac      240

ttccagagcg ccatttggag cggcttcatc aaagtgaaga agtccgacga gtacaccttc      300

gccacctccg ccgacaacca cgtgaccatg tgggtggacg accaggaagt gatcaacaag      360

gccagcaaca gcaacaagat ccggctggaa aagggccggc tgtaccagat caagatccag      420

taccagagag agaaccccac cgagaagggc ctggacttca agctgtactg gaccgacagc      480

cagaacaaga aagaagtgat cagcagcgac aacctgcagc tgcccgagct gaagcagaag      540

tccagcaact cccggaagaa gcggagcacc agcgccggac ccaccgtgcc cgaccgggac      600

aacgacggca tccccgacag cctggaagtg gagggctaca ccgtggacgt gaagaacaag      660

cggaccttcc tgagcccctg gatcagcaac atccacgaga agaaggggct gaccaagtac      720

aagagcagcc ccgagaagtg gagcaccgcc agcgacccct acagcgactt cgagaaagtg      780

accggccgga tcgacaagaa cgtgtccccc gaggccagac accctctggt ggccgcctac      840

cccatcgtgc acgtggacat ggaaaatatc atcctgagca agaacgagga ccagagcacc      900

cagaacaccg actcccagac ccggaccatc agcaagaaca ccagcaccag cagaacccac      960

acaagcgaag tgcacggcaa cgccgaagtg cacgccagct ttttcgacat cggagggagc     1020

gtgtccgccg gcttcagcaa ctccaacagc agcaccgtgg ccatcgacca cagcctgagc     1080

ctggccggcg agagaacctg ggccgagaca atgggcctga acaccgccga caccgccaga     1140

ctgaacgcca acatccgcta cgtgaacacc ggcaccgccc ccatctacaa cgtgctgccc     1200

accacctccc tggtgctggg caagaaccag accctggcca ccatcaaggc caaagagaac     1260

cagctgtccc agatcctggc ccccaacaac tactacccca gcaagaacct ggcccctatc     1320

gccctgaacg cccaggacga cttctcttct acccccatca ccatgaacta caaccagttt     1380

ctggaactgg aaaagaccaa gcagctgcgg ctggacaccg accaggtgta cggcaatatc     1440

gccacctaca acttcgagaa cggcagagtg cgcgtggaca ccggcagcaa ttggagcgag     1500

gtgctgcctc agatccagga aaccaccgcc cggatcatct tcaacggcaa ggacctgaac     1560

ctggtggagc ggcggatcgc cgccgtgaac ccctccgacc ccctggaaac caccaagccc     1620

gacatgaccc tgaaagaggc cctgaagatc gccttcggct tcaacgagcc caacggcaac     1680

ctgcagtacc agggcaagga catcaccgag ttcgacttca acttcgacca gcagacctcc     1740

cagaacatca agaatcagct ggccgaactg aacgtgacca acatctacac agtgctggac     1800

aagatcaagc tgaatgccaa gatgaacatc ctgatccggg acaagcggtt ccactacgac     1860

cggaacaata tcgccgtggg cgccgacgag agcgtggtga aagaagccca ccgggaagtc     1920

attaacagct ccaccgaggg gctgctgctg aacatcgaca aggacatccg caagatcctg     1980

agcggctaca tcgtggagat cgaggacacc gagggcctga aagaagtcat taacgaccgc     2040

tacgacatgc tgaatatcag cagcctgcgg caggacggca agaccttcat cgacttcaag     2100

aagtacaacg acaagctgcc cctgtacatc agcaacccca actacaaagt gaacgtgtac     2160

gccgtgacca aagagaatac catcatcaac cctagcgaga acggcgacac ctccaccaac     2220

ggcatcaaga agatcctgat cttcagcaag aagggctacg agatcggcgg acccggccct     2280

aagaacctgg actgctgggt ggacaacgaa gaggacatcg acgtgatcct gaagaagtct     2340

accatcctga atctggacat caacaacgac atcatcagcg acatctccgg cttcaacagc     2400

agcgtgatca cctaccccga cgcccagctg gtgcctggca tcaatggcaa ggccatccac     2460

ctggtgaaca acgagagcag cgaagtgatc gtgcacaagg ccatggacat cgagtacaac     2520

gatatgttca acaacttcac cgtgtccttt tggctgcggg tgcccaaggt gtccgccagc     2580

cacctggaac agtacggcac caacgagtac agcatcatca gcagcatgaa gaagcacagc     2640

ctgtccatcg gcagcgggtg gagcgtgtcc ctgaagggca acaacctgat ctggaccctg     2700

aaggactctg ccggcgaagt gcggcagatc accttccgcg acctgcccga caagttcaac     2760

gcctacctgg ccaataagtg ggtgttcatc accatcacca acgacagact gtccagcgcc     2820

aacctgtata tcaacggcgt gctgatgggc agcgccgaga tcacaggcct gggcgccatc     2880

cgggaggaca acaacatcac cctgaagctg gaccggtgca acaacaacaa ccagtacgtg     2940

tccatcgaca agttccgcat cttctgcaag gccctgaatc ccaaagagat cgagaagctg     3000

tacaccagct acctgtccat cacctttctg cgggatttct ggggcaaccc tctgagatac     3060

gacaccgagt actacctgat ccccgtggcc agcagctcca aggacgtgca gctgaagaac     3120

atcaccgact acatgtacct gaccaacgcc cccagctaca ccaatggcaa gctgaacatc     3180

tactaccggc ggctgtacaa cggcctgaag ttcatcatca agcggtacac ccccaacaat     3240

gagatcgaca gcttcgtgaa gtccggcgac ttcatcaagc tgtatgtgtc ctacaacaac     3300

aatgagcaca tcgtgggcta ccccaaggac gggaacgcct tcaacaacct ggaccggatc     3360

ctgagagtgg gctacaacgc ccctggcatc cccctgtaca agaaaatgga agccgtgaag     3420

ctgcgggacc tgaaaaccta ctctgtgcag ctgaaactgt acgacgacaa gaacgccagc     3480

ctgggcctgg tggggaccca caacggccag atcggcaacg accccaaccg ggatatcctg     3540

atcgccagca actggtactt caaccacctg aaggacaaga tcctgggctg cgattggtac     3600

ttcgtgccca ccgacgaggg ctggaccaac gacaagcttt ga                        3642


<210>  8
<211>  1213
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Glu Val Lys Gln Glu Asn Arg Leu Leu Asn Glu 
            20                  25                  30          


Ser Glu Ser Ser Ser Gln Gly Leu Leu Gly Tyr Tyr Phe Ser Asp Leu 
        35                  40                  45              


Asn Phe Gln Ala Pro Met Val Val Thr Ser Ser Thr Thr Gly Asp Leu 
    50                  55                  60                  


Ser Ile Pro Ser Ser Glu Leu Glu Asn Ile Pro Ser Glu Asn Gln Tyr 
65                  70                  75                  80  


Phe Gln Ser Ala Ile Trp Ser Gly Phe Ile Lys Val Lys Lys Ser Asp 
                85                  90                  95      


Glu Tyr Thr Phe Ala Thr Ser Ala Asp Asn His Val Thr Met Trp Val 
            100                 105                 110         


Asp Asp Gln Glu Val Ile Asn Lys Ala Ser Asn Ser Asn Lys Ile Arg 
        115                 120                 125             


Leu Glu Lys Gly Arg Leu Tyr Gln Ile Lys Ile Gln Tyr Gln Arg Glu 
    130                 135                 140                 


Asn Pro Thr Glu Lys Gly Leu Asp Phe Lys Leu Tyr Trp Thr Asp Ser 
145                 150                 155                 160 


Gln Asn Lys Lys Glu Val Ile Ser Ser Asp Asn Leu Gln Leu Pro Glu 
                165                 170                 175     


Leu Lys Gln Lys Ser Ser Asn Ser Arg Lys Lys Arg Ser Thr Ser Ala 
            180                 185                 190         


Gly Pro Thr Val Pro Asp Arg Asp Asn Asp Gly Ile Pro Asp Ser Leu 
        195                 200                 205             


Glu Val Glu Gly Tyr Thr Val Asp Val Lys Asn Lys Arg Thr Phe Leu 
    210                 215                 220                 


Ser Pro Trp Ile Ser Asn Ile His Glu Lys Lys Gly Leu Thr Lys Tyr 
225                 230                 235                 240 


Lys Ser Ser Pro Glu Lys Trp Ser Thr Ala Ser Asp Pro Tyr Ser Asp 
                245                 250                 255     


Phe Glu Lys Val Thr Gly Arg Ile Asp Lys Asn Val Ser Pro Glu Ala 
            260                 265                 270         


Arg His Pro Leu Val Ala Ala Tyr Pro Ile Val His Val Asp Met Glu 
        275                 280                 285             


Asn Ile Ile Leu Ser Lys Asn Glu Asp Gln Ser Thr Gln Asn Thr Asp 
    290                 295                 300                 


Ser Gln Thr Arg Thr Ile Ser Lys Asn Thr Ser Thr Ser Arg Thr His 
305                 310                 315                 320 


Thr Ser Glu Val His Gly Asn Ala Glu Val His Ala Ser Phe Phe Asp 
                325                 330                 335     


Ile Gly Gly Ser Val Ser Ala Gly Phe Ser Asn Ser Asn Ser Ser Thr 
            340                 345                 350         


Val Ala Ile Asp His Ser Leu Ser Leu Ala Gly Glu Arg Thr Trp Ala 
        355                 360                 365             


Glu Thr Met Gly Leu Asn Thr Ala Asp Thr Ala Arg Leu Asn Ala Asn 
    370                 375                 380                 


Ile Arg Tyr Val Asn Thr Gly Thr Ala Pro Ile Tyr Asn Val Leu Pro 
385                 390                 395                 400 


Thr Thr Ser Leu Val Leu Gly Lys Asn Gln Thr Leu Ala Thr Ile Lys 
                405                 410                 415     


Ala Lys Glu Asn Gln Leu Ser Gln Ile Leu Ala Pro Asn Asn Tyr Tyr 
            420                 425                 430         


Pro Ser Lys Asn Leu Ala Pro Ile Ala Leu Asn Ala Gln Asp Asp Phe 
        435                 440                 445             


Ser Ser Thr Pro Ile Thr Met Asn Tyr Asn Gln Phe Leu Glu Leu Glu 
    450                 455                 460                 


Lys Thr Lys Gln Leu Arg Leu Asp Thr Asp Gln Val Tyr Gly Asn Ile 
465                 470                 475                 480 


Ala Thr Tyr Asn Phe Glu Asn Gly Arg Val Arg Val Asp Thr Gly Ser 
                485                 490                 495     


Asn Trp Ser Glu Val Leu Pro Gln Ile Gln Glu Thr Thr Ala Arg Ile 
            500                 505                 510         


Ile Phe Asn Gly Lys Asp Leu Asn Leu Val Glu Arg Arg Ile Ala Ala 
        515                 520                 525             


Val Asn Pro Ser Asp Pro Leu Glu Thr Thr Lys Pro Asp Met Thr Leu 
    530                 535                 540                 


Lys Glu Ala Leu Lys Ile Ala Phe Gly Phe Asn Glu Pro Asn Gly Asn 
545                 550                 555                 560 


Leu Gln Tyr Gln Gly Lys Asp Ile Thr Glu Phe Asp Phe Asn Phe Asp 
                565                 570                 575     


Gln Gln Thr Ser Gln Asn Ile Lys Asn Gln Leu Ala Glu Leu Asn Val 
            580                 585                 590         


Thr Asn Ile Tyr Thr Val Leu Asp Lys Ile Lys Leu Asn Ala Lys Met 
        595                 600                 605             


Asn Ile Leu Ile Arg Asp Lys Arg Phe His Tyr Asp Arg Asn Asn Ile 
    610                 615                 620                 


Ala Val Gly Ala Asp Glu Ser Val Val Lys Glu Ala His Arg Glu Val 
625                 630                 635                 640 


Ile Asn Ser Ser Thr Glu Gly Leu Leu Leu Asn Ile Asp Lys Asp Ile 
                645                 650                 655     


Arg Lys Ile Leu Ser Gly Tyr Ile Val Glu Ile Glu Asp Thr Glu Gly 
            660                 665                 670         


Leu Lys Glu Val Ile Asn Asp Arg Tyr Asp Met Leu Asn Ile Ser Ser 
        675                 680                 685             


Leu Arg Gln Asp Gly Lys Thr Phe Ile Asp Phe Lys Lys Tyr Asn Asp 
    690                 695                 700                 


Lys Leu Pro Leu Tyr Ile Ser Asn Pro Asn Tyr Lys Val Asn Val Tyr 
705                 710                 715                 720 


Ala Val Thr Lys Glu Asn Thr Ile Ile Asn Pro Ser Glu Asn Gly Asp 
                725                 730                 735     


Thr Ser Thr Asn Gly Ile Lys Lys Ile Leu Ile Phe Ser Lys Lys Gly 
            740                 745                 750         


Tyr Glu Ile Gly Gly Pro Gly Pro Lys Asn Leu Asp Cys Trp Val Asp 
        755                 760                 765             


Asn Glu Glu Asp Ile Asp Val Ile Leu Lys Lys Ser Thr Ile Leu Asn 
    770                 775                 780                 


Leu Asp Ile Asn Asn Asp Ile Ile Ser Asp Ile Ser Gly Phe Asn Ser 
785                 790                 795                 800 


Ser Val Ile Thr Tyr Pro Asp Ala Gln Leu Val Pro Gly Ile Asn Gly 
                805                 810                 815     


Lys Ala Ile His Leu Val Asn Asn Glu Ser Ser Glu Val Ile Val His 
            820                 825                 830         


Lys Ala Met Asp Ile Glu Tyr Asn Asp Met Phe Asn Asn Phe Thr Val 
        835                 840                 845             


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gln 
    850                 855                 860                 


Tyr Gly Thr Asn Glu Tyr Ser Ile Ile Ser Ser Met Lys Lys His Ser 
865                 870                 875                 880 


Leu Ser Ile Gly Ser Gly Trp Ser Val Ser Leu Lys Gly Asn Asn Leu 
                885                 890                 895     


Ile Trp Thr Leu Lys Asp Ser Ala Gly Glu Val Arg Gln Ile Thr Phe 
            900                 905                 910         


Arg Asp Leu Pro Asp Lys Phe Asn Ala Tyr Leu Ala Asn Lys Trp Val 
        915                 920                 925             


Phe Ile Thr Ile Thr Asn Asp Arg Leu Ser Ser Ala Asn Leu Tyr Ile 
    930                 935                 940                 


Asn Gly Val Leu Met Gly Ser Ala Glu Ile Thr Gly Leu Gly Ala Ile 
945                 950                 955                 960 


Arg Glu Asp Asn Asn Ile Thr Leu Lys Leu Asp Arg Cys Asn Asn Asn 
                965                 970                 975     


Asn Gln Tyr Val Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala Leu 
            980                 985                 990         


Asn Pro Lys Glu Ile Glu Lys Leu  Tyr Thr Ser Tyr Leu  Ser Ile Thr 
        995                 1000                 1005             


Phe Leu  Arg Asp Phe Trp Gly  Asn Pro Leu Arg Tyr  Asp Thr Glu 
    1010                 1015                 1020             


Tyr Tyr  Leu Ile Pro Val Ala  Ser Ser Ser Lys Asp  Val Gln Leu 
    1025                 1030                 1035             


Lys Asn  Ile Thr Asp Tyr Met  Tyr Leu Thr Asn Ala  Pro Ser Tyr 
    1040                 1045                 1050             


Thr Asn  Gly Lys Leu Asn Ile  Tyr Tyr Arg Arg Leu  Tyr Asn Gly 
    1055                 1060                 1065             


Leu Lys  Phe Ile Ile Lys Arg  Tyr Thr Pro Asn Asn  Glu Ile Asp 
    1070                 1075                 1080             


Ser Phe  Val Lys Ser Gly Asp  Phe Ile Lys Leu Tyr  Val Ser Tyr 
    1085                 1090                 1095             


Asn Asn  Asn Glu His Ile Val  Gly Tyr Pro Lys Asp  Gly Asn Ala 
    1100                 1105                 1110             


Phe Asn  Asn Leu Asp Arg Ile  Leu Arg Val Gly Tyr  Asn Ala Pro 
    1115                 1120                 1125             


Gly Ile  Pro Leu Tyr Lys Lys  Met Glu Ala Val Lys  Leu Arg Asp 
    1130                 1135                 1140             


Leu Lys  Thr Tyr Ser Val Gln  Leu Lys Leu Tyr Asp  Asp Lys Asn 
    1145                 1150                 1155             


Ala Ser  Leu Gly Leu Val Gly  Thr His Asn Gly Gln  Ile Gly Asn 
    1160                 1165                 1170             


Asp Pro  Asn Arg Asp Ile Leu  Ile Ala Ser Asn Trp  Tyr Phe Asn 
    1175                 1180                 1185             


His Leu  Lys Asp Lys Ile Leu  Gly Cys Asp Trp Tyr  Phe Val Pro 
    1190                 1195                 1200             


Thr Asp  Glu Gly Trp Thr Asn  Asp Lys Leu 
    1205                 1210             


<210>  9
<211>  786
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence encoding hCD40L

<400>  9
atgatcgaaa catacaacca aacttctccc cgatctgcgg ccactggact gcccatcagc       60

atgaaaattt tcatgtattt acttactgtc tttcttatca cccagatgat tgggtcagca      120

ctttttgctg tgtatcttca tagaaggttg gacaagatag aagatgaaag gaatcttcat      180

gaagattttg tattcatgaa aacgatacag agatgcaaca caggagaaag atccttatcc      240

ttactgaact gtgaggagat taaaagccag tttgaaggct ttgtgaagga tataatgtta      300

aacaaagagg agacgaagaa agaaaacagc tttgaaatgc aaaaaggtga tcagaatcct      360

caaattgcgg cacatgtcat aagtgaggcc agcagtaaaa caacatctgt gttacagtgg      420

gctgaaaaag gatactacac catgagcaac aacttggtaa ccctggaaaa tgggaaacag      480

ctgaccgtta aaagacaagg actctattat atctatgccc aagtcacctt ctgttccaat      540

cgggaagctt cgagtcaagc tccatttata gccagcctct gcctaaagtc tcccggtaga      600

ttcgagagaa tcttactcag agctgcaaat acccacagtt ccgccaaacc ttgcgggcaa      660

caatccattc acttgggagg agtatttgaa ttgcaaccag gtgcttcggt gtttgtcaat      720

gtgactgatc caagccaagt gagccatggc actggcttca cgtcctttgg cttactcaaa      780

ctctga                                                                 786


<210>  10
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  11
<211>  726
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence encoding hIL15R-Sushi

<400>  11
atggccccca gacgggccag aggctgtaga accctgggac tgcctgccct gctgctgctc       60

ctcctgctga ggcctcctgc cacccggggc atcacctgtc ccccacccat gagcgtggaa      120

cacgccgaca tctgggtcaa gagctacagc ctgtacagca gagagcggta catctgcaac      180

agcggcttca agcggaaggc cggcaccagc agcctgaccg agtgcgtgct gaacaaggcc      240

accaacgtgg cccactggac cacccccagc ctgaagtgca tcagggaccc cgccctggtg      300

catcagaggc ctgctcctcc aagcggcgga tctggcggcg gaggaagtgg cggaggatca      360

ggcggaggcg gcagcctgca gaactgggtc aacgtgatca gcgacctgaa gaagatcgag      420

gacctgatcc agagcatgca catcgacgcc accctgtaca ccgagagcga cgtgcacccc      480

agctgcaaag tgaccgccat gaagtgcttt ctgctggaac tgcaggtcat cagcctggaa      540

agcggcgacg ccagcatcca cgacaccgtg gaaaacctga tcatcctggc caacaacagc      600

ctgagcagca acggcaacgt gaccgagagc ggctgcaaag agtgcgagga actggaagag      660

aagaatatca aagagttcct gcagagcttc gtgcacatcg tgcagatgtt catcaacacc      720

agctga                                                                 726


<210>  12
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn 
        115                 120                 125             


Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
    130                 135                 140                 


Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
145                 150                 155                 160 


Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
                165                 170                 175     


Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
            180                 185                 190         


Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr 
        195                 200                 205             


Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
    210                 215                 220                 


Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
225                 230                 235                 240 


Ser 
    


<210>  13
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  13
atggttgctg ggagcgacgc ggggcgggcc ctgggggtcc tcagcgtggt ctgcctgctg       60

cactgctttg gtttcatcag ctgtttttcc caacaaatat atggtgttgt gtatgggaat      120

gtaactttcc atgtaccaag caatgtgcct ttaaaagagg tcctatggaa aaaacaaaag      180

gataaagttg cagaactgga aaattctgaa ttcagagctt tctcatcttt taaaaatagg      240

gtttatttag acactgtgtc aggtagcctc actatctaca acttaacatc atcagatgaa      300

gatgagtatg aaatggaatc gccaaatatt actgatacca tgaagttctt tctttatgtg      360

cttgagtctc ttccatctcc cacactaact tgtgcattga ctaatggaag cattgaagtc      420

caatgcatga taccagagca ttacaacagc catcgaggac ttataatgta ctcatgggat      480

tgtcctatgg agcaatgtaa acgtaactca accagtatat attttaagat ggaaaatgat      540

cttccacaaa aaatacagtg tactcttagc aatccattat ttaatacaac atcatcaatc      600

attttgacaa cctgtatccc aagcagcggt cattcaagac acagatatgc acttataccc      660

ataccattag cagtaattac aacatgtatt gtgctgtata tgaatggtat tctgaaatgt      720

gacagaaaac cagacagaac caactccaat tga                                   753


<210>  14
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Ala Gly Ser Asp Ala Gly Arg Ala Leu Gly Val Leu Ser Val 
1               5                   10                  15      


Val Cys Leu Leu His Cys Phe Gly Phe Ile Ser Cys Phe Ser Gln Gln 
            20                  25                  30          


Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val Pro Ser Asn 
        35                  40                  45              


Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp Lys Val Ala 
    50                  55                  60                  


Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe Lys Asn Arg 
65                  70                  75                  80  


Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu Thr 
                85                  90                  95      


Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr Asp 
            100                 105                 110         


Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Leu Pro Ser Pro Thr 
        115                 120                 125             


Leu Thr Cys Ala Leu Thr Asn Gly Ser Ile Glu Val Gln Cys Met Ile 
    130                 135                 140                 


Pro Glu His Tyr Asn Ser His Arg Gly Leu Ile Met Tyr Ser Trp Asp 
145                 150                 155                 160 


Cys Pro Met Glu Gln Cys Lys Arg Asn Ser Thr Ser Ile Tyr Phe Lys 
                165                 170                 175     


Met Glu Asn Asp Leu Pro Gln Lys Ile Gln Cys Thr Leu Ser Asn Pro 
            180                 185                 190         


Leu Phe Asn Thr Thr Ser Ser Ile Ile Leu Thr Thr Cys Ile Pro Ser 
        195                 200                 205             


Ser Gly His Ser Arg His Arg Tyr Ala Leu Ile Pro Ile Pro Leu Ala 
    210                 215                 220                 


Val Ile Thr Thr Cys Ile Val Leu Tyr Met Asn Gly Ile Leu Lys Cys 
225                 230                 235                 240 


Asp Arg Lys Pro Asp Arg Thr Asn Ser Asn 
                245                 250 


<210>  15
<211>  1599
<212>  DNA
<213>  Homo sapiens

<400>  15
atggctccca gcagcccccg gcccgcgctg cccgcactcc tggtcctgct cggggctctg       60

ttcccaggac ctggcaatgc ccagacatct gtgtccccct caaaagtcat cctgccccgg      120

ggaggctccg tgctggtgac atgcagcacc tcctgtgacc agcccaagtt gttgggcata      180

gagaccccgt tgcctaaaaa ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa      240

ctgagcaatg tgcaagaaga tagccaacca atgtgctatt caaactgccc tgatgggcag      300

tcaacagcta aaaccttcct caccgtgtac tggactccag aacgggtgga actggcaccc      360

ctcccctctt ggcagccagt gggcaagaac cttaccctac gctgccaggt ggagggtggg      420

gcaccccggg ccaacctcac cgtggtgctg ctccgtgggg agaaggagct gaaacgggag      480

ccagctgtgg gggagcccgc tgaggtcacg accacggtgc tggtgaggag agatcaccat      540

ggagccaatt tctcgtgccg cactgaactg gacctgcggc cccaagggct ggagctgttt      600

gagaacacct cggcccccta ccagctccag acctttgtcc tgccagcgac tcccccacaa      660

cttgtcagcc cccgggtcct agaggtggac acgcagggga ccgtggtctg ttccctggac      720

gggctgttcc cagtctcgga ggcccaggtc cacctggcac tgggggacca gaggttgaac      780

cccacagtca cctatggcaa cgactccttc tcggccaagg cctcagtcag tgtgaccgca      840

gaggacgagg gcacccagcg gctgacgtgt gcagtaatac tggggaacca gagccaggag      900

acactgcaga cagtgaccat ctacagcttt ccggcgccca acgtgattct gacgaagcca      960

gaggtctcag aagggaccga ggtgacagtg aagtgtgagg cccaccctag agccaaggtg     1020

acgctgaatg gggttccagc ccagccactg ggcccgaggg cccagctcct gctgaaggcc     1080

accccagagg acaacgggcg cagcttctcc tgctctgcaa ccctggaggt ggccggccag     1140

cttatacaca agaaccagac ccgggagctt cgtgtcctgt atggcccccg actggacgag     1200

agggattgtc cgggaaactg gacgtggcca gaaaattccc agcagactcc aatgtgccag     1260

gcttggggga acccattgcc cgagctcaag tgtctaaagg atggcacttt cccactgccc     1320

atcggggaat cagtgactgt cactcgagat cttgagggca cctacctctg tcgggccagg     1380

agcactcaag gggaggtcac ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag     1440

attgtcatca tcactgtggt agcagccgca gtcataatgg gcactgcagg cctcagcacg     1500

tacctctata accgccagcg gaagatcaag aaatacagac tacaacaggc ccaaaaaggg     1560

acccccatga aaccgaacac acaagccacg cctccctag                            1599


<210>  16
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  17
<211>  867
<212>  DNA
<213>  Homo sapiens

<400>  17
atgggccaca cacggaggca gggaacatca ccatccaagt gtccatacct caatttcttt       60

cagctcttgg tgctggctgg tctttctcac ttctgttcag gtgttatcca cgtgaccaag      120

gaagtgaaag aagtggcaac gctgtcctgt ggtcacaatg tttctgttga agagctggca      180

caaactcgca tctactggca aaaggagaag aaaatggtgc tgactatgat gtctggggac      240

atgaatatat ggcccgagta caagaaccgg accatctttg atatcactaa taacctctcc      300

attgtgatcc tggctctgcg cccatctgac gagggcacat acgagtgtgt tgttctgaag      360

tatgaaaaag acgctttcaa gcgggaacac ctggctgaag tgacgttatc agtcaaagct      420

gacttcccta cacctagtat atctgacttt gaaattccaa cttctaatat tagaaggata      480

atttgctcaa cctctggagg ttttccagag cctcacctct cctggttgga aaatggagaa      540

gaattaaatg ccatcaacac aacagtttcc caagatcctg aaactgagct ctatgctgtt      600

agcagcaaac tggatttcaa tatgacaacc aaccacagct tcatgtgtct catcaagtat      660

ggacatttaa gagtgaatca gaccttcaac tggaatacaa ccaagcaaga gcattttcct      720

gataacctgc tcccatcctg ggccattacc ttaatctcag taaatggaat ttttgtgata      780

tgctgcctga cctactgctt tgccccaaga tgcagagaga gaaggaggaa tgagagattg      840

agaagggaaa gtgtacgccc tgtataa                                          867


<210>  18
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  19
<211>  2031
<212>  DNA
<213>  Artificial sequence

<220>
<223>  codon-optimized DNA encoding GP-ZEBOV-Mayinga (GenBank Accession 
       No. ABX75367.1)

<400>  19
atgggcgtga caggcattct gcagctcccc agagacagat tcaagcggac ctcctttttc       60

ctctgggtca tcattctgtt tcagcggacc ttctccatcc ctctgggcgt gatccacaat      120

agcaccctcc aggtgtccga cgtggacaag ctcgtgtgcc gggacaagct gtcctccacc      180

aaccagctga gaagcgtggg gctgaatctc gagggcaatg gcgtggccac agacgtgccc      240

tccgccacaa agcgctgggg ctttcggagc ggcgtccctc ctaaagtcgt gaactacgag      300

gcaggggaat gggctgaaaa ttgttacaat ctcgagatca aaaaaccaga tggctctgag      360

tgcctgcctg ccgcaccaga cggcatcagg ggcttcccta gatgccgcta tgtgcacaag      420

gtgagtggta caggcccttg tgccggcgat tttgcctttc acaaagaggg ggctttcttt      480

ctgtacgaca ggctcgccag tacagtgata taccgaggta ctaccttcgc cgaaggcgtg      540

gtggcctttc tgattctgcc ccaggccaag aaggacttct tcagcagcca ccccctgaga      600

gaacccgtga acgccacaga ggaccccagc agcggctact acagcaccac aatcagatac      660

caggccacag gcttcggcac caatgagaca gagtacctgt tcgaggtgga caacctgacc      720

tacgtgcagc tggaaagccg gtttacccct cagttcctcc tgcagctcaa cgagacaatc      780

tacacctccg gcaagcggag caacacaaca ggcaagctca tctggaaagt gaaccccgag      840

atcgatacca ctatagggga gtgggctttc tgggaaacta agaagaacct cacccggaag      900

atcagatccg aggaactgtc cttcaccgtg gtgtccaacg gcgccaagaa catttcagga      960

cagagccccg ccagaacaag cagcgacccc ggcaccaaca ccacaaccga ggaccacaag     1020

atcatggcca gcgagaactc cagcgccatg gtgcaggtcc acagccaggg aagagaagcc     1080

gccgtgagcc acctgaccac actggccacc atcagcacca gcccccagag cctgaccacc     1140

aagcctggcc ccgacaacag cacacacaac acccccgtgt acaagctgga catcagcgag     1200

gccacccagg tggagcagca ccacagacgg accgacaacg acagcaccgc cagcgatacc     1260

ccttctgcca ccacagccgc cggaccccct aaggccgaga ataccaacac cagcaagagc     1320

accgactttc tggatccagc caccaccacc agtccacaga accacagcga aaccgccggc     1380

aacaacaata cccaccacca ggacaccggc gaggaaagcg ccagctctgg caagctgggc     1440

ctgattacca acacaatcgc cggcgtggcc ggactgatca ccggcggcag acggaccaga     1500

cgggaggcca tcgtgaacgc ccagcccaaa tgtaatccta atctccacta ttggaccaca     1560

caggacgagg gcgctgccat cggactggca tggattcctt acttcggacc agccgctgaa     1620

gggatctata tcgaggggct catgcataac caggatggtc tgatttgtgg tctccggcag     1680

ctggctaatg agacaacaca ggctctccag ctgtttctga gagccacaac agagctgaga     1740

accttcagca ttctcaaccg caaggctatt gacttcctgc tccaacgatg gggaggcaca     1800

tgccacatcc tggggcctga ttgttgtatc gaacctcacg attggacaaa gaacattaca     1860

gataagatcg atcagattat ccatgacttt gtggacaaga ccctgcccga tcagggcgac     1920

aacgataatt ggtggacagg gtggagacag tggattccag ccgggattgg cgtgaccggc     1980

gtgattatcg ccgtgatcgc cctgttctgc atctgcaagt tcgtgttctg a              2031


<210>  20
<211>  676
<212>  PRT
<213>  ZEBOV-Mayinga

<400>  20

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  21
<211>  159
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence encoding VV B5R anchor

<400>  21
cctaagcctt ctacacctcc tggcagcagc gccacctacc acatcatcat cgtggccctg       60

acaattatgg gcgtgatctt cctgatcagc gtgatcgtgc tcgtgtgcag ctgcgacaag      120

aacaacgacc agtacaagtt ccacaagctg ctgccctga                             159


<210>  22
<211>  42
<212>  PRT
<213>  Vaccinia Virus

<400>  22

Ala Thr Tyr His Ile Ile Ile Val Ala Leu Thr Ile Met Gly Val Ile 
1               5                   10                  15      


Phe Leu Ile Ser Val Ile Val Leu Val Cys Ser Cys Asp Lys Asn Asn 
            20                  25                  30          


Asp Gln Tyr Lys Phe His Lys Leu Leu Pro 
        35                  40          


<210>  23
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  promoter sequence

<400>  23
aaaaattgaa attttatttt ttttttttgg aatataaata                             40


<210>  24
<211>  234
<212>  DNA
<213>  Artificial sequence

<220>
<223>  promoter sequence

<400>  24
aaaaattgaa attttatttt ttttttttgg aatataaata aaaaattgaa aaactattct       60

aatttattgc acggtccggt aaaaattgaa aaactattct aatttattgc acggtccggt      120

aaaaattgaa aaactattct aatttattgc acggtccggt aaaaattgaa aaactattct      180

aatttattgc acggtccggt aaaaattgaa aaactattct aatttattgc acgg            234


<210>  25
<211>  104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  promoter sequence

<400>  25
tccaaaccca cccgcttttt atagtaagtt tttcacccat aaataataaa tacaataatt       60

aatttctcgt aaaagtagaa aatatattct aatttattgc acgg                       104


<210>  26
<211>  119
<212>  DNA
<213>  Fowlpox virus

<400>  26
ttaatgtata gaactaattt ataataaaca tagtaaatat gggtaacttc ttaatagcca       60

taattaaaat tgaaaaaaaa atatcattat aaaacgtaaa cgaacaaaaa acattaatt       119


<210>  27
<211>  227
<212>  DNA
<213>  Artificial sequence

<220>
<223>  promoter sequence

<400>  27
gttttgaaaa tttttttata ataaatatcc ggtaaaaatt gaaaaactat tctaatttat       60

tgcacggtcc ggtaaaaatt gaaaaactat tctaatttat tgcacggtcc ggtaaaaatt      120

gaaaaactat tctaatttat tgcacggtcc ggtaaaaatt gaaaaactat tctaatttat      180

tgcacggtcc ggtaaaaatt gaaaaactat tctaatttat tgcacgg                    227


<210>  28
<211>  2220
<212>  DNA
<213>  Artificial sequence

<220>
<223>  codon-optimized DNA sequence encoding NP-EBOV-CdI (GenBank 
       Accession No. ACI28629.1)

<400>  28
atggaaagca gggcccacaa ggcctggatg acacacaccg ccagcggctt cgagacagac       60

taccacaaga tcctgacagc cggcctgtct gtgcagcagg gcatcgtgcg gcagcgcgtg      120

atccaggtgc accaggtgac caacctggaa gagatctgcc agctgatcat ccaggccttc      180

gaggccggcg tggacttcca ggaaagcgcc gacagcttcc tgctgatgct gtgcctgcac      240

cacgcctacc agggcgacta caagcagttc ctggaaagca acgccgtgaa gtacctggaa      300

gggcacggct tcagattcga agtgcggaag aaagaaggcg tgaagcggct ggaagaactg      360

ctgcctgccg ccagctccgg caagagcatc agacgcaccc tggccgccat gcccgaggaa      420

gagacaaccg aggccaacgc tggccagttc ctgagcttcg ccagcctgtt cctgcctaag      480

ctggtggtgg gcgagaaggc ctgcctggaa aaggtgcagc ggcagattca ggtgcacagc      540

gagcagggcc tgatccagta ccctaccgcc tggcagagcg tgggccacat gatggtgatc      600

ttccggctga tgcggaccaa cttcctgatc aagtttctgc tgatccacca gggaatgcac      660

atggtggctg gccacgacgc caatgacgcc gtgatcgcca atagcgtggc ccaggccaga      720

ttcagcggcc tgctgatcgt gaaaacagtg ctggaccaca tcctgcagaa aaccgagcac      780

ggcgtgagac tgcaccctct ggcccggacc gccaaagtga agaacgaagt gaacagcttc      840

aaggccgccc tgtctagcct ggcccagcac ggcgagtacg cccctttcgc ccggctgctg      900

aacctgagcg gcgtgaacaa tctggaacac ggactgttcc cccagctgag cgccattgcc      960

ctgggagtgg ccacagccca cggctctaca ctggccggcg tgaacgtggg cgagcagtac     1020

cagcagctga gagaggccgc cacagaggcc gagaagcagc tgcagaagta cgccgagagc     1080

cgggagctgg atcacctggg cctggacgac caggaaaaga agatcctgaa ggacttccac     1140

cagaagaaga acgagatcag cttccagcag accaccgcca tggtgaccct gcggaaagag     1200

cggctggcca agctgaccga ggccatcacc tccaccagcc tgctgaaaac cggcaagcag     1260

tacgacgacg acaatgacat ccccttccct ggccccatca acgacaacga gaactccgag     1320

cagcaggacg atgaccccac cgatagccag gataccacca tccccgacat catcgtggac     1380

cccgacgacg gccggtacaa caactacggc gactacccca gcgagacagc caatgccccc     1440

gaggacctgg tgctgttcga cctggaagat ggcgacgagg acgaccacag acccagcagc     1500

tccagcgaga acaacaacaa gcacagcctg accggcaccg acagcaacaa gaccagcaac     1560

tggaaccgga accccaccaa catgcccaag aaggacagca cccagaacaa cgacaacccc     1620

gcccagagag cccaggaata cgcccgggac aacatccagg acacccctac ccctcacaga     1680

gccctgaccc ccatcagcga ggaaaccggc tccaacggcc acaacgagga cgatatcgac     1740

agcatccccc ccctggaatc cgacgaggaa aacaacaccg aaaccaccat caccaccaca     1800

aagaacacca ccgcccctcc cgcccctgtg taccggtcca acagcgagaa agagcccctg     1860

cctcaggaaa agagccagaa acagcccaat caggtgtccg gcagcgagaa taccgacaac     1920

aagccccaca gcgaacagag cgtggaggaa atgtaccggc acattctgca gacccagggc     1980

cccttcgacg ccatcctgta ctactacatg atgacagagg aacccatcgt gttcagcacc     2040

tccgacggca aagaatacgt gtaccccgac agcctggaag gcgagcaccc tccctggctg     2100

agcgaaaaag aggccctgaa cgaggacaac cggttcatca ccatggacga tcagcagttc     2160

tactggcccg tgatgaacca ccggaacaag ttcatggcca tcctgcagca ccacaagtga     2220


<210>  29
<211>  739
<212>  PRT
<213>  EBOV-CdI

<400>  29

Met Glu Ser Arg Ala His Lys Ala Trp Met Thr His Thr Ala Ser Gly 
1               5                   10                  15      


Phe Glu Thr Asp Tyr His Lys Ile Leu Thr Ala Gly Leu Ser Val Gln 
            20                  25                  30          


Gln Gly Ile Val Arg Gln Arg Val Ile Gln Val His Gln Val Thr Asn 
        35                  40                  45              


Leu Glu Glu Ile Cys Gln Leu Ile Ile Gln Ala Phe Glu Ala Gly Val 
    50                  55                  60                  


Asp Phe Gln Glu Ser Ala Asp Ser Phe Leu Leu Met Leu Cys Leu His 
65                  70                  75                  80  


His Ala Tyr Gln Gly Asp Tyr Lys Gln Phe Leu Glu Ser Asn Ala Val 
                85                  90                  95      


Lys Tyr Leu Glu Gly His Gly Phe Arg Phe Glu Val Arg Lys Lys Glu 
            100                 105                 110         


Gly Val Lys Arg Leu Glu Glu Leu Leu Pro Ala Ala Ser Ser Gly Lys 
        115                 120                 125             


Ser Ile Arg Arg Thr Leu Ala Ala Met Pro Glu Glu Glu Thr Thr Glu 
    130                 135                 140                 


Ala Asn Ala Gly Gln Phe Leu Ser Phe Ala Ser Leu Phe Leu Pro Lys 
145                 150                 155                 160 


Leu Val Val Gly Glu Lys Ala Cys Leu Glu Lys Val Gln Arg Gln Ile 
                165                 170                 175     


Gln Val His Ser Glu Gln Gly Leu Ile Gln Tyr Pro Thr Ala Trp Gln 
            180                 185                 190         


Ser Val Gly His Met Met Val Ile Phe Arg Leu Met Arg Thr Asn Phe 
        195                 200                 205             


Leu Ile Lys Phe Leu Leu Ile His Gln Gly Met His Met Val Ala Gly 
    210                 215                 220                 


His Asp Ala Asn Asp Ala Val Ile Ala Asn Ser Val Ala Gln Ala Arg 
225                 230                 235                 240 


Phe Ser Gly Leu Leu Ile Val Lys Thr Val Leu Asp His Ile Leu Gln 
                245                 250                 255     


Lys Thr Glu His Gly Val Arg Leu His Pro Leu Ala Arg Thr Ala Lys 
            260                 265                 270         


Val Lys Asn Glu Val Asn Ser Phe Lys Ala Ala Leu Ser Ser Leu Ala 
        275                 280                 285             


Gln His Gly Glu Tyr Ala Pro Phe Ala Arg Leu Leu Asn Leu Ser Gly 
    290                 295                 300                 


Val Asn Asn Leu Glu His Gly Leu Phe Pro Gln Leu Ser Ala Ile Ala 
305                 310                 315                 320 


Leu Gly Val Ala Thr Ala His Gly Ser Thr Leu Ala Gly Val Asn Val 
                325                 330                 335     


Gly Glu Gln Tyr Gln Gln Leu Arg Glu Ala Ala Thr Glu Ala Glu Lys 
            340                 345                 350         


Gln Leu Gln Lys Tyr Ala Glu Ser Arg Glu Leu Asp His Leu Gly Leu 
        355                 360                 365             


Asp Asp Gln Glu Lys Lys Ile Leu Lys Asp Phe His Gln Lys Lys Asn 
    370                 375                 380                 


Glu Ile Ser Phe Gln Gln Thr Thr Ala Met Val Thr Leu Arg Lys Glu 
385                 390                 395                 400 


Arg Leu Ala Lys Leu Thr Glu Ala Ile Thr Ser Thr Ser Leu Leu Lys 
                405                 410                 415     


Thr Gly Lys Gln Tyr Asp Asp Asp Asn Asp Ile Pro Phe Pro Gly Pro 
            420                 425                 430         


Ile Asn Asp Asn Glu Asn Ser Glu Gln Gln Asp Asp Asp Pro Thr Asp 
        435                 440                 445             


Ser Gln Asp Thr Thr Ile Pro Asp Ile Ile Val Asp Pro Asp Asp Gly 
    450                 455                 460                 


Arg Tyr Asn Asn Tyr Gly Asp Tyr Pro Ser Glu Thr Ala Asn Ala Pro 
465                 470                 475                 480 


Glu Asp Leu Val Leu Phe Asp Leu Glu Asp Gly Asp Glu Asp Asp His 
                485                 490                 495     


Arg Pro Ser Ser Ser Ser Glu Asn Asn Asn Lys His Ser Leu Thr Gly 
            500                 505                 510         


Thr Asp Ser Asn Lys Thr Ser Asn Trp Asn Arg Asn Pro Thr Asn Met 
        515                 520                 525             


Pro Lys Lys Asp Ser Thr Gln Asn Asn Asp Asn Pro Ala Gln Arg Ala 
    530                 535                 540                 


Gln Glu Tyr Ala Arg Asp Asn Ile Gln Asp Thr Pro Thr Pro His Arg 
545                 550                 555                 560 


Ala Leu Thr Pro Ile Ser Glu Glu Thr Gly Ser Asn Gly His Asn Glu 
                565                 570                 575     


Asp Asp Ile Asp Ser Ile Pro Pro Leu Glu Ser Asp Glu Glu Asn Asn 
            580                 585                 590         


Thr Glu Thr Thr Ile Thr Thr Thr Lys Asn Thr Thr Ala Pro Pro Ala 
        595                 600                 605             


Pro Val Tyr Arg Ser Asn Ser Glu Lys Glu Pro Leu Pro Gln Glu Lys 
    610                 615                 620                 


Ser Gln Lys Gln Pro Asn Gln Val Ser Gly Ser Glu Asn Thr Asp Asn 
625                 630                 635                 640 


Lys Pro His Ser Glu Gln Ser Val Glu Glu Met Tyr Arg His Ile Leu 
                645                 650                 655     


Gln Thr Gln Gly Pro Phe Asp Ala Ile Leu Tyr Tyr Tyr Met Met Thr 
            660                 665                 670         


Glu Glu Pro Ile Val Phe Ser Thr Ser Asp Gly Lys Glu Tyr Val Tyr 
        675                 680                 685             


Pro Asp Ser Leu Glu Gly Glu His Pro Pro Trp Leu Ser Glu Lys Glu 
    690                 695                 700                 


Ala Leu Asn Glu Asp Asn Arg Phe Ile Thr Met Asp Asp Gln Gln Phe 
705                 710                 715                 720 


Tyr Trp Pro Val Met Asn His Arg Asn Lys Phe Met Ala Ile Leu Gln 
                725                 730                 735     


His His Lys 
            


<210>  30
<211>  2031
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized DNA sequence encoding GP-SEBOV-Gulu (GenBank 
       Accession No. AAU43887.1)

<400>  30
atgggcggcc tgagcctgct gcagctgccc cgggacaagt tccggaagtc cagcttcttc       60

gtgtgggtga tcatcctgtt ccagaaagcc ttcagcatgc ccctgggcgt ggtgaccaac      120

agcaccctgg aagtgaccga gatcgaccag ctggtgtgca aggaccacct ggccagcacc      180

gatcagctga agtccgtggg cctgaacctg gaaggcagcg gcgtgagcac cgacatcccc      240

agcgccacca agagatgggg cttcagatcc ggcgtgcccc ccaaggtggt gtcttatgag      300

gccggcgagt gggccgagaa ctgctacaac ctggaaatca agaagcccga cggcagcgag      360

tgtctgcctc cccctcccga tggcgtgaga ggcttccccc ggtgcagata cgtgcacaag      420

gcacaaggca ccggtccatg cccaggcgac tacgccttcc acaaggacgg cgcctttttc      480

ctgtacgacc ggctggcctc caccgtgatc taccggggcg tgaactttgc cgagggcgtg      540

atcgccttcc tgatcctggc caagcccaaa gagacattcc tgcagagccc ccccatccgg      600

gaggccgtga actacaccga gaacaccagc agctactacg ccacctccta cctggaatac      660

gagatcgaga acttcggcgc ccagcacagc accaccctgt tcaagatcga caacaacacc      720

ttcgtgcggc tggacagacc ccacaccccc cagtttctgt tccagctgaa cgacaccatc      780

catctgcatc agcagctgtc caacaccacc ggcagactga tctggaccct ggacgccaac      840

atcaacgccg acatcggtga atgggctttt tgggagaaca agaagaatct gagcgagcag      900

ctgcggggcg aagaactcag cttcgaggcc ctgagcctga acgagacaga ggacgacgac      960

gccgccagca gccggatcac caagggccgg atcagcgacc gggccaccag aaagtacagc     1020

gacctggtgc ccaagaacag ccccggcatg gtgcctctgc acatccccga gggcgagaca     1080

actctcccta gtcagaatag caccgagggc agacgggtgg gcgtgaacac ccaggaaacc     1140

atcaccgaga cagccgccac catcattggt actaacggca accacatgca gatcagcacc     1200

atcggcatcc ggcccagcag cagccagatc ccaagtagta gtcctaccac agcccctagc     1260

cctgaggccc agacccctac cacacacacc agcggcccta gcgtgatggc caccgaggaa     1320

cctaccaccc ctcctggcag cagcccaggt ccaactaccg aggcaccaac cctgaccacc     1380

cccgagaaca tcaccaccgc cgtgaaaacc gtgctgcccc aggaaagcac cagcaacggc     1440

ctgatcacca gcaccgtgac cggcatcctg ggcagcctgg gcctgcggaa gcggagcaga     1500

cggcagacca acaccaaggc caccggcaag tgcaacccca acctgcacta ctggaccgcc     1560

caggaacagc acaacgccgc tgggatcgcc tggatcccct actttggtcc tggtgctgag     1620

ggaatataca ccgagggcct gatgcacaac cagaacgccc tggtgtgcgg cctgagacag     1680

ctggccaacg aaaccactca ggcactgcag ctgttcctgc gggccaccac cgagctgcgg     1740

acctacacca tcctgaacag gaaggccatc gactttctgc tgcggagatg gggcggcacc     1800

tgtagaatcc tgggccccga ctgctgcatc gagccccacg actggaccaa gaatatcacc     1860

gacaagatca accagatcat ccacgacttc atcgacaacc ccctgcccaa ccaggacaac     1920

gacgacaact ggtggactgg ttggcgacag tggatccctg ccggcatcgg catcaccggc     1980

atcatcattg ccattatcgc tctcctctgc gtgtgcaagc tcctctgctg a              2031


<210>  31
<211>  676
<212>  PRT
<213>  SEBOV-Gulu

<400>  31

Met Gly Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Ala Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Val Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asp Asn Asn Thr 
225                 230                 235                 240 


Phe Val Arg Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile His Leu His Gln Gln Leu Ser Asn Thr Thr Gly Arg 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Leu Ser Glu Gln Leu Arg Gly Glu 
    290                 295                 300                 


Glu Leu Ser Phe Glu Ala Leu Ser Leu Asn Glu Thr Glu Asp Asp Asp 
305                 310                 315                 320 


Ala Ala Ser Ser Arg Ile Thr Lys Gly Arg Ile Ser Asp Arg Ala Thr 
                325                 330                 335     


Arg Lys Tyr Ser Asp Leu Val Pro Lys Asn Ser Pro Gly Met Val Pro 
            340                 345                 350         


Leu His Ile Pro Glu Gly Glu Thr Thr Leu Pro Ser Gln Asn Ser Thr 
        355                 360                 365             


Glu Gly Arg Arg Val Gly Val Asn Thr Gln Glu Thr Ile Thr Glu Thr 
    370                 375                 380                 


Ala Ala Thr Ile Ile Gly Thr Asn Gly Asn His Met Gln Ile Ser Thr 
385                 390                 395                 400 


Ile Gly Ile Arg Pro Ser Ser Ser Gln Ile Pro Ser Ser Ser Pro Thr 
                405                 410                 415     


Thr Ala Pro Ser Pro Glu Ala Gln Thr Pro Thr Thr His Thr Ser Gly 
            420                 425                 430         


Pro Ser Val Met Ala Thr Glu Glu Pro Thr Thr Pro Pro Gly Ser Ser 
        435                 440                 445             


Pro Gly Pro Thr Thr Glu Ala Pro Thr Leu Thr Thr Pro Glu Asn Ile 
    450                 455                 460                 


Thr Thr Ala Val Lys Thr Val Leu Pro Gln Glu Ser Thr Ser Asn Gly 
465                 470                 475                 480 


Leu Ile Thr Ser Thr Val Thr Gly Ile Leu Gly Ser Leu Gly Leu Arg 
                485                 490                 495     


Lys Arg Ser Arg Arg Gln Thr Asn Thr Lys Ala Thr Gly Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Ala Gln Glu Gln His Asn Ala Ala Gly 
        515                 520                 525             


Ile Ala Trp Ile Pro Tyr Phe Gly Pro Gly Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asn Ala Leu Val Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Tyr Thr Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Arg Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asn 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Ile Asp Asn Pro Leu Pro Asn Gln Asp Asn 
625                 630                 635                 640 


Asp Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Ile Ile Ile Ala Ile Ile Ala Leu Leu Cys Val Cys 
            660                 665                 670         


Lys Leu Leu Cys 
        675     


<210>  32
<211>  187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  promoter sequence

<400>  32
gttttgaaaa tttttttata ataaatatcc ggtaaaaatt gaaaaactat tctaatttat       60

tgcacggtcc ggtaaaaatt gaaaaactat tctaatttat tgcacggtcc ggtaaaaatt      120

gaaaaactat tctaatttat tgcacggtcc ggtaaaaatt gaaaaactat tctaatttat      180

tgcacgg                                                                187


<210>  33
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  codon-optimized VP40 sequence

<400>  33
atgcggcgcg tgatcctgcc caccgcccct ccagagtaca tggaagccat ctaccccgtg       60

cggagcaaca gcacaatcgc cagaggcggc aacagcaata ccggcttcct gacccccgag      120

agcgtgaacg gcgacacccc cagcaacccc ctgaggccta tcgccgacga caccatcgac      180

cacgccagcc acacccctgg cagcgtgtcc agcgccttca tcctggaagc catggtgaac      240

gtgatcagcg gccccaaggt gctgatgaag cagatcccca tctggctgcc cctgggcgtg      300

gccgaccaga aaacctacag cttcgacagc accaccgccg ccatcatgct ggccagctac      360

accatcaccc acttcggcaa ggccaccaac cccctggtgc gcgtgaacag actgggccct      420

ggcatccccg accaccccct gagactgctg cggatcggca accaggcctt cctgcaggaa      480

ttcgtgctgc cccccgtgca gctgccccag tacttcacct tcgacctgac cgccctgaag      540

ctgatcaccc agcctctgcc tgccgccacc tggaccgatg atacccccac aggcagcaac      600

ggcgccctga ggcccggcat cagcttccac cccaagctga ggcccatcct gctgcccaac      660

aagagcggca agaagggcaa cagcgccgac ctgacctccc ccgagaagat ccaggccatc      720

atgaccagcc tgcaggactt caagatcgtg cccatcgacc ccaccaagaa catcatgggc      780

atcgaggtgc ccgagacact ggtgcacaag ctgaccggca agaaagtgac cagcaagaac      840

ggccagccca tcatccctgt gctgctgcct aagtacatcg gcctggaccc cgtggcccct      900

ggcgacctga ccatggtgat cacacaggac tgcgatacct gccacagccc cgccagcctg      960

cccgccgtga ttgagaagta atag                                             984


<210>  34
<211>  326
<212>  PRT
<213>  ZEBOV-Mayinga

<400>  34

Met Arg Arg Val Ile Leu Pro Thr Ala Pro Pro Glu Tyr Met Glu Ala 
1               5                   10                  15      


Ile Tyr Pro Val Arg Ser Asn Ser Thr Ile Ala Arg Gly Gly Asn Ser 
            20                  25                  30          


Asn Thr Gly Phe Leu Thr Pro Glu Ser Val Asn Gly Asp Thr Pro Ser 
        35                  40                  45              


Asn Pro Leu Arg Pro Ile Ala Asp Asp Thr Ile Asp His Ala Ser His 
    50                  55                  60                  


Thr Pro Gly Ser Val Ser Ser Ala Phe Ile Leu Glu Ala Met Val Asn 
65                  70                  75                  80  


Val Ile Ser Gly Pro Lys Val Leu Met Lys Gln Ile Pro Ile Trp Leu 
                85                  90                  95      


Pro Leu Gly Val Ala Asp Gln Lys Thr Tyr Ser Phe Asp Ser Thr Thr 
            100                 105                 110         


Ala Ala Ile Met Leu Ala Ser Tyr Thr Ile Thr His Phe Gly Lys Ala 
        115                 120                 125             


Thr Asn Pro Leu Val Arg Val Asn Arg Leu Gly Pro Gly Ile Pro Asp 
    130                 135                 140                 


His Pro Leu Arg Leu Leu Arg Ile Gly Asn Gln Ala Phe Leu Gln Glu 
145                 150                 155                 160 


Phe Val Leu Pro Pro Val Gln Leu Pro Gln Tyr Phe Thr Phe Asp Leu 
                165                 170                 175     


Thr Ala Leu Lys Leu Ile Thr Gln Pro Leu Pro Ala Ala Thr Trp Thr 
            180                 185                 190         


Asp Asp Thr Pro Thr Gly Ser Asn Gly Ala Leu Arg Pro Gly Ile Ser 
        195                 200                 205             


Phe His Pro Lys Leu Arg Pro Ile Leu Leu Pro Asn Lys Ser Gly Lys 
    210                 215                 220                 


Lys Gly Asn Ser Ala Asp Leu Thr Ser Pro Glu Lys Ile Gln Ala Ile 
225                 230                 235                 240 


Met Thr Ser Leu Gln Asp Phe Lys Ile Val Pro Ile Asp Pro Thr Lys 
                245                 250                 255     


Asn Ile Met Gly Ile Glu Val Pro Glu Thr Leu Val His Lys Leu Thr 
            260                 265                 270         


Gly Lys Lys Val Thr Ser Lys Asn Gly Gln Pro Ile Ile Pro Val Leu 
        275                 280                 285             


Leu Pro Lys Tyr Ile Gly Leu Asp Pro Val Ala Pro Gly Asp Leu Thr 
    290                 295                 300                 


Met Val Ile Thr Gln Asp Cys Asp Thr Cys His Ser Pro Ala Ser Leu 
305                 310                 315                 320 


Pro Ala Val Ile Glu Lys 
                325     


<210>  35
<211>  124
<212>  DNA
<213>  Artificial sequence

<220>
<223>  promoter sequence

<400>  35
taaaaataga aactataatc atataatagt gtaggttggt agtattgctc ttgtgactag       60

agactttagt taaggtactg taaaaataga aactataatc atataatagt gtaggttggt      120

agta                                                                   124


<210>  36
<211>  2046
<212>  DNA
<213>  Artificial sequence

<220>
<223>  codon-optimzed DNA sequence GP-MARV-Angola

<400>  36
atgaagacga cctgcctgct gatctcgctg attctgattc agggagtgaa aacccttccc       60

attctcgaga ttgcctctaa tatccagcca caaaatgtcg acagtgtgtg ttccggaacc      120

ctccagaaga cagaggatgt tcacctcatg ggattcactc tgtctggaca gaaagtcgca      180

gactctcctc tcgaggctag caaaagatgg gctttccggg caggtgtccc accaaaaaac      240

gtcgagtata ctgaaggcga agaagctaag acttgttata acatttccgt caccgatccc      300

agtggaaaat ccctccttct ggatccacca actaacatta gggattaccc gaaatgtaag      360

acaattcatc acattcaagg acagaaccct catgcccaag ggattgccct ccatctctgg      420

ggtgcattct ttctgtacga caggatcgca tctacaacaa tgtatagagg caaagtcttc      480

acggaaggga acatagctgc tatgatagtt aacaaaacag ttcacaaaat gattttcagt      540

cggcaagggc agggataccg ccatatgaat ttgacctcga ctaacaaata ctggacatcc      600

tcgaacggaa cccaaacaaa cgatactggc tgtttcggga cactccagga gtacaactct      660

acaaagaacc aaacgtgcgc tccctctaag aagccactgc ctcttcccac cgcccaccct      720

gaagtgaagc tcacatctac cagcacagat gccactaagc tcaacacgac agaccctaat      780

tctgatgacg aggatctcac cacatccggc tccgggagcg gcgagcaaga accctacacc      840

acatctgacg cagccacaaa gcaagggctg tccagcacta tgccacctac tcctagccca      900

caacccagta cacctcaaca gggagggaac aatacaaatc attctcaggg cgtggtcaca      960

gagcccggca agaccaacac aactgctcag ccttctatgc ctcctcacaa taccacaacg     1020

atttcgacga ataacacgag caaacacaat ctgagcacac ccagcgtgcc catccagaac     1080

gccacaaatt acaatacaca gtctacagct ccagagaatg aacagacatc cgctcccagc     1140

aagaccacgc tgctgcctac cgagaatcca acaaccgcta aatccaccaa tagcaccaag     1200

tctcccacca ccaccgtgcc taacaccaca aacaagtaca gcacctctcc cagccctaca     1260

cctaactcca ccgctcagca tctcgtgtat tttcgccgca agagaaacat cctctggaga     1320

gagggagata tgtttccatt tctcgacggg ctcattaatg cgcctatcga ttttgatccg     1380

gttccgaaca caaagacgat ctttgatgag tctagctcta gcggagcctc agcagaggaa     1440

gaccaacatg ctagtcctaa tatttccctc accctgtcct atttccctaa agtgaatgaa     1500

aataccgctc actctggaga aaacgaaaat gactgtgacg ctgaactccg gatttggtcc     1560

gttcaggagg atgatctcgc cgcaggactc tcttggattc ccttctttgg accagggatc     1620

gaaggactgt atacagctgg actcatcaaa aatcagaaca atctcgtgtg tcggctcagg     1680

cggctcgcta accaaactgc caaaagcctt gagctccttc tgcgggtcac cacagaggaa     1740

agaacatttt ctctgattaa tcgccacgct atagactttc ttctcgctcg gtggggtgga     1800

acctgcaaag tcctcggacc tgattgctgt atcggaattg aagatctgtc gcggaatatc     1860

tccgagcaaa tcgatcagat taagaaagat gagcaaaagg aaggtacagg gtggggattg     1920

ggtggaaaat ggtggacttc cgattggggt gtcctcacta atctcgggat cctcctcctg     1980

ctctccattg ccgtcctgat cgctctgtca tgtatttgca gaatctttac aaagtatatt     2040

gggtga                                                                2046


<210>  37
<211>  681
<212>  PRT
<213>  MARV-Angola

<400>  37

Met Lys Thr Thr Cys Leu Leu Ile Ser Leu Ile Leu Ile Gln Gly Val 
1               5                   10                  15      


Lys Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Ile Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Ala Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Thr Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Lys Pro Leu Pro Leu Pro Thr Ala His Pro 
225                 230                 235                 240 


Glu Val Lys Leu Thr Ser Thr Ser Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Ala Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Gly Val Val Thr 
305                 310                 315                 320 


Glu Pro Gly Lys Thr Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Leu Ser 
            340                 345                 350         


Thr Pro Ser Val Pro Ile Gln Asn Ala Thr Asn Tyr Asn Thr Gln Ser 
        355                 360                 365             


Thr Ala Pro Glu Asn Glu Gln Thr Ser Ala Pro Ser Lys Thr Thr Leu 
    370                 375                 380                 


Leu Pro Thr Glu Asn Pro Thr Thr Ala Lys Ser Thr Asn Ser Thr Lys 
385                 390                 395                 400 


Ser Pro Thr Thr Thr Val Pro Asn Thr Thr Asn Lys Tyr Ser Thr Ser 
                405                 410                 415     


Pro Ser Pro Thr Pro Asn Ser Thr Ala Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Asn Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Pro Asn Ile Ser Leu Thr Leu Ser Tyr Phe Pro 
                485                 490                 495     


Lys Val Asn Glu Asn Thr Ala His Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Ala Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


