                         SEQUENCE LISTING

<110>  RSEM, LIMITED PARTNERSHIP
       Sapieha, Przemyslaw
       Beaulieu, Normand
 
<120>  COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING INFLAMMATION

<130>  765/12810.550

<150>  US 62/046,459
<151>  2014-09-05

<160>  128   

<170>  PatentIn version 3.5

<210>  1
<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        835                 840                 845             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    850                 855                 860                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
865                 870                 875                 880 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                885                 890                 895     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            900                 905                 910         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        915                 920                 925             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    930                 935                 940                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
945                 950                 955                 960 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                965                 970                 975     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            980                 985                 990         


Asp Ile Ala Val Glu Trp Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr 
        995                 1000                 1005             


Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu 
    1010                 1015                 1020             


Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn 
    1025                 1030                 1035             


Val Phe  Ser Cys Ser Val Met  His Glu Ala Leu His  Asn His Tyr 
    1040                 1045                 1050             


Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly Lys 
    1055                 1060                 


<210>  2
<211>  3255
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctgacaaa     2580

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     2640

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     2700

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     2760

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     2820

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     2880

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     2940

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     3000

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     3060

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     3120

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     3180

ttctcatgct ccgtgatgca cgaggctctg cacaaccact acacgcagaa gagcctctcc     3240

ctgtctccgg gtaaa                                                      3255


<210>  3
<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (563)..(837)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        835                 840                 845             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    850                 855                 860                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
865                 870                 875                 880 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                885                 890                 895     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            900                 905                 910         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        915                 920                 925             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    930                 935                 940                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
945                 950                 955                 960 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                965                 970                 975     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            980                 985                 990         


Asp Ile Ala Val Glu Trp Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr 
        995                 1000                 1005             


Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu 
    1010                 1015                 1020             


Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn 
    1025                 1030                 1035             


Val Phe  Ser Cys Ser Val Met  His Glu Ala Leu His  Asn His Tyr 
    1040                 1045                 1050             


Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly Lys 
    1055                 1060                 


<210>  4
<211>  3255
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1750)..(2574)
<223>  n is a, c, g, or t

<400>  4
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1800

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1860

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1920

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1980

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2040

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2100

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2160

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2220

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2280

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2340

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2400

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2460

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2520

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngacaaa     2580

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     2640

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     2700

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     2760

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     2820

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     2880

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     2940

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     3000

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     3060

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     3120

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     3180

ttctcatgct ccgtgatgca cgaggctctg cacaaccact acacgcagaa gagcctctcc     3240

ctgtctccgg gtaaa                                                      3255


<210>  5
<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (404)..(837)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        835                 840                 845             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    850                 855                 860                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
865                 870                 875                 880 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                885                 890                 895     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            900                 905                 910         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        915                 920                 925             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    930                 935                 940                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
945                 950                 955                 960 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                965                 970                 975     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            980                 985                 990         


Asp Ile Ala Val Glu Trp Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr 
        995                 1000                 1005             


Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu 
    1010                 1015                 1020             


Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn 
    1025                 1030                 1035             


Val Phe  Ser Cys Ser Val Met  His Glu Ala Leu His  Asn His Tyr 
    1040                 1045                 1050             


Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly Lys 
    1055                 1060                 


<210>  6
<211>  3255
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1273)..(2574)
<223>  n is a, c, g, or t

<400>  6
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1320

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1380

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1440

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1500

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1560

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1620

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1680

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1740

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1800

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1860

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1920

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1980

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2040

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2100

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2160

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2220

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2280

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2340

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2400

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2460

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2520

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngacaaa     2580

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     2640

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     2700

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     2760

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     2820

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     2880

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     2940

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     3000

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     3060

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     3120

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     3180

ttctcatgct ccgtgatgca cgaggctctg cacaaccact acacgcagaa gagcctctcc     3240

ctgtctccgg gtaaa                                                      3255


<210>  7
<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (245)..(837)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        835                 840                 845             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    850                 855                 860                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
865                 870                 875                 880 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                885                 890                 895     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            900                 905                 910         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        915                 920                 925             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    930                 935                 940                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
945                 950                 955                 960 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                965                 970                 975     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            980                 985                 990         


Asp Ile Ala Val Glu Trp Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr 
        995                 1000                 1005             


Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu 
    1010                 1015                 1020             


Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn 
    1025                 1030                 1035             


Val Phe  Ser Cys Ser Val Met  His Glu Ala Leu His  Asn His Tyr 
    1040                 1045                 1050             


Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly Lys 
    1055                 1060                 


<210>  8
<211>  3255
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (796)..(2574)
<223>  n is a, c, g, or t

<400>  8
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      840

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      900

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      960

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1020

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1080

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1140

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1200

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1260

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1320

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1380

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1440

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1500

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1560

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1620

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1680

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1740

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1800

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1860

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1920

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1980

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2040

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2100

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2160

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2220

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2280

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2340

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2400

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2460

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2520

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngacaaa     2580

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     2640

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     2700

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     2760

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     2820

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     2880

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     2940

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     3000

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     3060

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     3120

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     3180

ttctcatgct ccgtgatgca cgaggctctg cacaaccact acacgcagaa gagcctctcc     3240

ctgtctccgg gtaaa                                                      3255


<210>  9
<211>  791
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                565                 570                 575     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            580                 585                 590         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        595                 600                 605             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    610                 615                 620                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
625                 630                 635                 640 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                645                 650                 655     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            660                 665                 670         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        675                 680                 685             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    690                 695                 700                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
705                 710                 715                 720 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                725                 730                 735     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            740                 745                 750         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        755                 760                 765             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    770                 775                 780                 


Leu Ser Leu Ser Pro Gly Lys 
785                 790     


<210>  10
<211>  2436
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgta gatctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1800

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1860

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1920

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1980

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     2040

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     2100

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     2160

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     2220

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     2280

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     2340

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc acgaggctct gcacaaccac     2400

tacacgcaga agagcctctc cctgtctccg ggtaaa                               2436


<210>  11
<211>  632
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                405                 410                 415     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            420                 425                 430         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        435                 440                 445             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    450                 455                 460                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
465                 470                 475                 480 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                485                 490                 495     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            500                 505                 510         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        515                 520                 525             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    530                 535                 540                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
545                 550                 555                 560 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                565                 570                 575     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            580                 585                 590         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        595                 600                 605             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    610                 615                 620                 


Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630         


<210>  12
<211>  1959
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcagatctga caaaactcac acatgcccac cgtgcccagc acctgaactc     1320

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     1380

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1440

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1500

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1560

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1620

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1680

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1740

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1800

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1860

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac     1920

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1959


<210>  13
<211>  473
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  14
<211>  1482
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgagatc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      840

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      900

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      960

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1020

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1080

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1140

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1200

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1260

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1320

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1380

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcacga ggctctgcac     1440

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1482


<210>  15
<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        835                 840                 845             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    850                 855                 860                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
865                 870                 875                 880 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                885                 890                 895     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            900                 905                 910         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        915                 920                 925             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    930                 935                 940                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
945                 950                 955                 960 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                965                 970                 975     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            980                 985                 990         


Asp Ile Ala Val Glu Trp Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr 
        995                 1000                 1005             


Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu 
    1010                 1015                 1020             


Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn 
    1025                 1030                 1035             


Val Phe  Ser Cys Ser Val Met  His Glu Ala Leu His  Asn His Tyr 
    1040                 1045                 1050             


Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly Lys 
    1055                 1060                 


<210>  16
<211>  3255
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctgacaaa     2580

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     2640

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     2700

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     2760

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     2820

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     2880

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     2940

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     3000

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     3060

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     3120

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     3180

ttctcatgct ccgtgatgca cgaggctctg cacaaccact acacgcagaa gagcctctcc     3240

ctgtctccgg gtaaa                                                      3255


<210>  17
<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (563)..(837)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        835                 840                 845             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    850                 855                 860                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
865                 870                 875                 880 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                885                 890                 895     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            900                 905                 910         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        915                 920                 925             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    930                 935                 940                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
945                 950                 955                 960 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                965                 970                 975     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            980                 985                 990         


Asp Ile Ala Val Glu Trp Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr 
        995                 1000                 1005             


Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu 
    1010                 1015                 1020             


Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn 
    1025                 1030                 1035             


Val Phe  Ser Cys Ser Val Met  His Glu Ala Leu His  Asn His Tyr 
    1040                 1045                 1050             


Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly Lys 
    1055                 1060                 


<210>  18
<211>  3255
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1750)..(2574)
<223>  n is a, c, g, or t

<400>  18
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1800

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1860

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1920

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1980

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2040

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2100

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2160

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2220

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2280

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2340

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2400

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2460

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2520

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngacaaa     2580

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     2640

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     2700

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     2760

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     2820

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     2880

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     2940

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     3000

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     3060

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     3120

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     3180

ttctcatgct ccgtgatgca cgaggctctg cacaaccact acacgcagaa gagcctctcc     3240

ctgtctccgg gtaaa                                                      3255


<210>  19
<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (404)..(837)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        835                 840                 845             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    850                 855                 860                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
865                 870                 875                 880 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                885                 890                 895     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            900                 905                 910         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        915                 920                 925             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    930                 935                 940                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
945                 950                 955                 960 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                965                 970                 975     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            980                 985                 990         


Asp Ile Ala Val Glu Trp Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr 
        995                 1000                 1005             


Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu 
    1010                 1015                 1020             


Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn 
    1025                 1030                 1035             


Val Phe  Ser Cys Ser Val Met  His Glu Ala Leu His  Asn His Tyr 
    1040                 1045                 1050             


Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly Lys 
    1055                 1060                 


<210>  20
<211>  3255
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1273)..(2574)
<223>  n is a, c, g, or t

<400>  20
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1320

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1380

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1440

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1500

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1560

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1620

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1680

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1740

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1800

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1860

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1920

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1980

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2040

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2100

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2160

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2220

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2280

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2340

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2400

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2460

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2520

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngacaaa     2580

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     2640

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     2700

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     2760

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     2820

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     2880

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     2940

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     3000

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     3060

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     3120

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     3180

ttctcatgct ccgtgatgca cgaggctctg cacaaccact acacgcagaa gagcctctcc     3240

ctgtctccgg gtaaa                                                      3255


<210>  21
<211>  791
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                565                 570                 575     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            580                 585                 590         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        595                 600                 605             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    610                 615                 620                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
625                 630                 635                 640 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                645                 650                 655     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            660                 665                 670         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        675                 680                 685             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    690                 695                 700                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
705                 710                 715                 720 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                725                 730                 735     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            740                 745                 750         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        755                 760                 765             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    770                 775                 780                 


Leu Ser Leu Ser Pro Gly Lys 
785                 790     


<210>  22
<211>  2436
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgta gatctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1800

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1860

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1920

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1980

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     2040

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     2100

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     2160

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     2220

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     2280

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     2340

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc acgaggctct gcacaaccac     2400

tacacgcaga agagcctctc cctgtctccg ggtaaa                               2436


<210>  23
<211>  632
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                405                 410                 415     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            420                 425                 430         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        435                 440                 445             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    450                 455                 460                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
465                 470                 475                 480 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                485                 490                 495     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            500                 505                 510         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        515                 520                 525             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    530                 535                 540                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
545                 550                 555                 560 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                565                 570                 575     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            580                 585                 590         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        595                 600                 605             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    610                 615                 620                 


Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630         


<210>  24
<211>  1962
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcagatctga caaaactcac acatgcccac cgtgcccagc acctgaactc     1320

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     1380

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1440

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1500

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1560

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1620

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1680

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1740

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1800

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1860

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac     1920

cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                        1962


<210>  25
<211>  1065
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys Ile Glu Asn Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly Gly Arg Leu Trp Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Ile Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Gln Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Val Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Lys Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp Trp Ile Ser Leu Lys 
            340                 345                 350         


Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Leu Gly Val Phe Ser Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Val Ser Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ala Ser Asn Gln Ala 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Thr 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr Thr Asn Glu Trp Leu 
    450                 455                 460                 


Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg Gly Val Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Thr Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Ser Pro Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Pro Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Ile Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Ser His Ala Gln Leu Arg Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Ser Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Val Val Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Thr Asp Leu Asp Lys Lys Asn Thr Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Val Ser Ser Thr Met Val Arg Ser Gly Cys Lys Pro Cys 
        835                 840                 845             


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
    850                 855                 860                 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
865                 870                 875                 880 


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
                885                 890                 895     


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
            900                 905                 910         


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
        915                 920                 925             


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
    930                 935                 940                 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
945                 950                 955                 960 


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
                965                 970                 975     


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
            980                 985                 990         


Glu Asp Ile Thr Val Glu Trp Gln  Trp Asn Gly Gln Pro  Ala Glu Asn 
        995                 1000                 1005             


Tyr Lys  Asn Thr Gln Pro Ile  Met Asp Thr Asp Gly  Ser Tyr Phe 
    1010                 1015                 1020             


Val Tyr  Ser Lys Leu Asn Val  Gln Lys Ser Asn Trp  Glu Ala Gly 
    1025                 1030                 1035             


Asn Thr  Phe Thr Cys Ser Val  Leu His Glu Gly Leu  His Asn His 
    1040                 1045                 1050             


His Thr  Glu Lys Ser Leu Ser  His Ser Pro Gly Lys  
    1055                 1060                 1065 


<210>  26
<211>  3261
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
atggagaggg ggctgccgtt gctgtgcgcc acgctcgccc ttgccctcgc cctggcgggc       60

gctttccgca gcgacaaatg tggcgggacc ataaaaatcg aaaacccagg gtacctcaca      120

tctcccggtt accctcattc ttaccatcca agtgagaagt gtgaatggct aatccaagct      180

ccggaaccct accagagaat catgatcaac ttcaacccac atttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtaatc gatggggaga atgaaggcgg ccgcctgtgg      300

gggaagttct gtgggaagat tgcaccttct cctgtggtgt cttcagggcc ctttctcttc      360

atcaaatttg tctctgacta tgagacacat ggggcagggt tttccatccg ctatgaaatc      420

ttcaagagag ggcccgaatg ttctcagaac tatacagcac ctactggagt gataaagtcc      480

cctgggttcc ctgaaaaata ccccaacagc ttggagtgca cctacatcat ctttgcacca      540

aagatgtctg agataatcct ggagtttgaa agttttgacc tggagcaaga ctcgaatcct      600

cccggaggaa tgttctgtcg ctatgaccgg ctggagatct gggatggatt ccctgaagtt      660

ggccctcaca ttgggcgtta ttgtgggcag aaaactcctg gccggatccg ctcctcttca      720

ggcgttctat ccatggtctt ttacactgac agcgcaatag caaaagaagg tttctcagcc      780

aactacagtg tgctacagag cagcatctct gaagatttta agtgtatgga ggctctgggc      840

atggaatctg gagagatcca ttctgatcag atcactgcat cttcacagta tggtaccaac      900

tggtctgtag agcgctcccg cctgaactac cctgaaaatg ggtggactcc aggagaagac      960

tcctacaagg agtggatcca ggtggacttg ggcctcctgc gattcgttac tgctgtaggg     1020

acacagggtg ccatttccaa ggaaaccaag aagaaatatt atgtcaagac ttacagagta     1080

gacatcagct ccaacggaga ggactggatc tccctgaaag agggaaataa agccattatc     1140

tttcagggaa acaccaaccc cacagatgtt gtcttaggag ttttctccaa accactgata     1200

actcgatttg tccgaatcaa acctgtatcc tgggaaactg gtatatctat gagatttgaa     1260

gtttatggct gcaagataac agattatcct tgctctggaa tgttgggcat ggtgtctgga     1320

cttatttcag actcccagat tacagcatcc aatcaagccg acaggaattg gatgccagaa     1380

aacatccgtc tggtgaccag tcgtaccggc tgggcactgc caccctcacc ccacccatac     1440

accaatgaat ggctccaagt ggacctggga gatgagaaga tagtaagagg tgtcatcatt     1500

cagggtggga agcaccgaga aaacaaggtg ttcatgagga agttcaagat cgcctatagt     1560

aacaatggct ctgactggaa aactatcatg gatgacagca agcgcaaggc taagtcgttc     1620

gaaggcaaca acaactatga cacacctgag cttcggacgt tttcacctct ctccacaagg     1680

ttcatcagga tctaccctga gagagccaca cacagtgggc ttgggctgag gatggagcta     1740

ctgggctgtg aagtggaagc acctacagct ggaccaacca cacccaatgg gaacccagtg     1800

gatgagtgtg acgacgacca ggccaactgc cacagtggca caggtgatga cttccagctc     1860

acaggaggca ccactgtcct ggccacagag aagccaacca ttatagacag caccatccaa     1920

tcagagttcc cgacatacgg ttttaactgc gagtttggct ggggctctca caagacattc     1980

tgccactggg agcatgacag ccatgcacag ctcaggtgga gtgtgctgac cagcaagaca     2040

gggccgattc aggaccatac aggagatggc aacttcatct attcccaagc tgatgaaaat     2100

cagaaaggca aagtagcccg cctggtgagc cctgtggtct attcccagag ctctgcccac     2160

tgtatgacct tctggtatca catgtccggc tctcatgtgg gtacactgag ggtcaaacta     2220

cgctaccaga agccagagga atatgatcaa ctggtctgga tggtggttgg gcaccaagga     2280

gaccactgga aagaaggacg tgtcttgctg cacaaatctc tgaaactata tcaggttatt     2340

tttgaaggtg aaatcggaaa aggaaacctt ggtggaattg ctgtggatga tatcagtatt     2400

aacaaccata tttctcagga agactgtgca aaaccaacag acctagataa aaagaacaca     2460

gaaattaaaa ttgatgaaac agggagcact ccaggatatg aaggagaagg ggaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg cttaagaccc tggatcccgt ctcgagcacc     2580

atggttagat ctggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc     2640

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt     2700

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat     2760

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc     2820

tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc     2880

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc     2940

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat     3000

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg     3060

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat     3120

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat     3180

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc     3240

tcccactctc ctggtaaatg a                                               3261


<210>  27
<211>  813
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Thr Leu Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Val Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Lys Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Ser Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Leu Gly Val Phe Ser Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Val Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Ala Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Thr Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Thr 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Ser Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Val Ser Ser Thr Met Val Arg Ser Gly 
            580                 585                 590         


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
        595                 600                 605             


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
    610                 615                 620                 


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
625                 630                 635                 640 


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
                645                 650                 655     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
            660                 665                 670         


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
        675                 680                 685             


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    690                 695                 700                 


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
705                 710                 715                 720 


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
                725                 730                 735     


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
            740                 745                 750         


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
        755                 760                 765             


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
    770                 775                 780                 


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
785                 790                 795                 800 


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
                805                 810             


<210>  28
<211>  2442
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
atggagaggg ggctgccgtt gctgtgcgcc acgctcgccc ttgccctcgc cctggcgggc       60

gctttccgca gcgacaaatg tggcgggacc ataaaaatcg aaaacccagg gtacctcaca      120

tctcccggtt accctcattc ttaccatcca agtgagaagt gtgaatggct aatccaagct      180

ccggaaccct accagagaat catgatcaac ttcaacccac atttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtaatc gatggggaga atgaaggcgg ccgcctgtgg      300

gggaagttct gtgggaagat tgcaccttct cctgtggtgt cttcagggcc ctttctcttc      360

atcaaatttg tctctgacta tgagacacat ggggcagggt tttccatccg ctatgaaatc      420

ttcaagagag ggcccgaatg ttctcagaac tatacagcac ctactggagt gataaagtcc      480

cctgggttcc ctgaaaaata ccccaacagc ttggagtgca cctacatcat ctttgcacca      540

aagatgtctg agataatcct ggagtttgaa agttttgacc tggagcaaga ctcgaatcct      600

cccggaggaa tgttctgtcg ctatgaccgg ctggagatct gggatggatt ccctgaagtt      660

ggccctcaca ttgggcgtta ttgtgggcag aaaactcctg gccggatccg ctcctcttca      720

ggcgttctat ccatggtctt ttacactgac agcgcaatag caaaagaagg tttctcagcc      780

aactacagtg tgctacagag cagcatctct gaagatttta agtgtatgga ggctctgggc      840

atggaatctg gagagatcca ttctgatcag atcactgcat cttcacagta tggtaccaac      900

tggtctgtag agcgctcccg cctgaactac cctgaaaatg ggtggactcc aggagaagac      960

tcctacaagg agtggatcca ggtggacttg ggcctcctgc gattcgttac tgctgtaggg     1020

acacagggtg ccatttccaa ggaaaccaag aagaaatatt atgtcaagac ttacagagta     1080

gacatcagct ccaacggaga ggactggatc tccctgaaag agggaaataa agccattatc     1140

tttcagggaa acaccaaccc cacagatgtt gtcttaggag ttttctccaa accactgata     1200

actcgatttg tccgaatcaa acctgtatcc tgggaaactg gtatatctat gagatttgaa     1260

gtttatggct gcaagataac agattatcct tgctctggaa tgttgggcat ggtgtctgga     1320

cttatttcag actcccagat tacagcatcc aatcaagccg acaggaattg gatgccagaa     1380

aacatccgtc tggtgaccag tcgtaccggc tgggcactgc caccctcacc ccacccatac     1440

accaatgaat ggctccaagt ggacctggga gatgagaaga tagtaagagg tgtcatcatt     1500

cagggtggga agcaccgaga aaacaaggtg ttcatgagga agttcaagat cgcctatagt     1560

aacaatggct ctgactggaa aactatcatg gatgacagca agcgcaaggc taagtcgttc     1620

gaaggcaaca acaactatga cacacctgag cttcggacgt tttcacctct ctccacaagg     1680

ttcatcagga tctaccctga gagagccaca cacagtgggc ttgggctgag gatggagcta     1740

ctgggctgtg tctcgagcac catggttaga tctggttgta agccttgcat atgtacagtc     1800

ccagaagtat catctgtctt catcttcccc ccaaagccca aggatgtgct caccattact     1860

ctgactccta aggtcacgtg tgttgtggta gacatcagca aggatgatcc cgaggtccag     1920

ttcagctggt ttgtagatga tgtggaggtg cacacagctc agacgcaacc ccgggaggag     1980

cagttcaaca gcactttccg ctcagtcagt gaacttccca tcatgcacca ggactggctc     2040

aatggcaagg agttcaaatg cagggtcaac agtgcagctt tccctgcccc catcgagaaa     2100

accatctcca aaaccaaagg cagaccgaag gctccacagg tgtacaccat tccacctccc     2160

aaggagcaga tggccaagga taaagtcagt ctgacctgca tgataacaga cttcttccct     2220

gaagacatta ctgtggagtg gcagtggaat gggcagccag cggagaacta caagaacact     2280

cagcccatca tggacacaga tggctcttac ttcgtctaca gcaagctcaa tgtgcagaag     2340

agcaactggg aggcaggaaa tactttcacc tgctctgtgt tacatgaggg cctgcacaac     2400

caccatactg agaagagcct ctcccactct cctggtaaat ga                        2442


<210>  29
<211>  633
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys Ile Glu Asn Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly Gly Arg Leu Trp Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Ile Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Gln Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Val Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Lys Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp Trp Ile Ser Leu Lys 
            340                 345                 350         


Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Leu Gly Val Phe Ser Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Val Ser Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Val Ser Ser Thr Met Val Arg Ser Gly Cys Lys Pro Cys 
                405                 410                 415     


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
            420                 425                 430         


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
        435                 440                 445             


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
    450                 455                 460                 


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
465                 470                 475                 480 


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
                485                 490                 495     


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
            500                 505                 510         


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
        515                 520                 525             


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
    530                 535                 540                 


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
545                 550                 555                 560 


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
                565                 570                 575     


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
            580                 585                 590         


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
        595                 600                 605             


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
    610                 615                 620                 


Lys Ser Leu Ser His Ser Pro Gly Lys 
625                 630             


<210>  30
<211>  1965
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
atggagaggg ggctgccgtt gctgtgcgcc acgctcgccc ttgccctcgc cctggcgggc       60

gctttccgca gcgacaaatg tggcgggacc ataaaaatcg aaaacccagg gtacctcaca      120

tctcccggtt accctcattc ttaccatcca agtgagaagt gtgaatggct aatccaagct      180

ccggaaccct accagagaat catgatcaac ttcaacccac atttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtaatc gatggggaga atgaaggcgg ccgcctgtgg      300

gggaagttct gtgggaagat tgcaccttct cctgtggtgt cttcagggcc ctttctcttc      360

atcaaatttg tctctgacta tgagacacat ggggcagggt tttccatccg ctatgaaatc      420

ttcaagagag ggcccgaatg ttctcagaac tatacagcac ctactggagt gataaagtcc      480

cctgggttcc ctgaaaaata ccccaacagc ttggagtgca cctacatcat ctttgcacca      540

aagatgtctg agataatcct ggagtttgaa agttttgacc tggagcaaga ctcgaatcct      600

cccggaggaa tgttctgtcg ctatgaccgg ctggagatct gggatggatt ccctgaagtt      660

ggccctcaca ttgggcgtta ttgtgggcag aaaactcctg gccggatccg ctcctcttca      720

ggcgttctat ccatggtctt ttacactgac agcgcaatag caaaagaagg tttctcagcc      780

aactacagtg tgctacagag cagcatctct gaagatttta agtgtatgga ggctctgggc      840

atggaatctg gagagatcca ttctgatcag atcactgcat cttcacagta tggtaccaac      900

tggtctgtag agcgctcccg cctgaactac cctgaaaatg ggtggactcc aggagaagac      960

tcctacaagg agtggatcca ggtggacttg ggcctcctgc gattcgttac tgctgtaggg     1020

acacagggtg ccatttccaa ggaaaccaag aagaaatatt atgtcaagac ttacagagta     1080

gacatcagct ccaacggaga ggactggatc tccctgaaag agggaaataa agccattatc     1140

tttcagggaa acaccaaccc cacagatgtt gtcttaggag ttttctccaa accactgata     1200

actcgatttg tccgaatcaa acctgtatcc tgggaaactg gtatatctat gagatttgaa     1260

gtttatggct gcgtctcgag caccatggtt agatctggtt gtaagccttg catatgtaca     1320

gtcccagaag tatcatctgt cttcatcttc cccccaaagc ccaaggatgt gctcaccatt     1380

actctgactc ctaaggtcac gtgtgttgtg gtagacatca gcaaggatga tcccgaggtc     1440

cagttcagct ggtttgtaga tgatgtggag gtgcacacag ctcagacgca accccgggag     1500

gagcagttca acagcacttt ccgctcagtc agtgaacttc ccatcatgca ccaggactgg     1560

ctcaatggca aggagttcaa atgcagggtc aacagtgcag ctttccctgc ccccatcgag     1620

aaaaccatct ccaaaaccaa aggcagaccg aaggctccac aggtgtacac cattccacct     1680

cccaaggagc agatggccaa ggataaagtc agtctgacct gcatgataac agacttcttc     1740

cctgaagaca ttactgtgga gtggcagtgg aatgggcagc cagcggagaa ctacaagaac     1800

actcagccca tcatggacac agatggctct tacttcgtct acagcaagct caatgtgcag     1860

aagagcaact gggaggcagg aaatactttc acctgctctg tgttacatga gggcctgcac     1920

aaccaccata ctgagaagag cctctcccac tctcctggta aatga                     1965


<210>  31
<211>  911
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val Glu Ala Pro Thr Ala 
                405                 410                 415     


Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp 
            420                 425                 430         


Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly 
        435                 440                 445             


Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr 
    450                 455                 460                 


Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp 
465                 470                 475                 480 


Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln 
                485                 490                 495     


Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His 
            500                 505                 510         


Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys 
        515                 520                 525             


Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser 
    530                 535                 540                 


Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly 
545                 550                 555                 560 


Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln 
                565                 570                 575     


Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly 
            580                 585                 590         


Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu 
        595                 600                 605             


Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile 
    610                 615                 620                 


Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp 
625                 630                 635                 640 


Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr 
                645                 650                 655     


Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys 
            660                 665                 670         


Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser Asp Lys Thr His 
        675                 680                 685             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    690                 695                 700                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
705                 710                 715                 720 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                725                 730                 735     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            740                 745                 750         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        755                 760                 765             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    770                 775                 780                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
785                 790                 795                 800 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                805                 810                 815     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            820                 825                 830         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        835                 840                 845             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    850                 855                 860                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
865                 870                 875                 880 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                885                 890                 895     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            900                 905                 910     


<210>  32
<211>  2799
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct gaagtggaag cccctacagc tggaccgacc     1320

actcccaacg ggaacttggt ggatgaatgt gatgacgacc aggccaactg ccacagtgga     1380

acaggtgatg acttccagct cacaggtggc accactgtgc tggccacaga aaagcccacg     1440

gtcatagaca gcaccataca atcagagttt ccaacatatg gttttaactg tgaatttggc     1500

tggggctctc acaagacctt ctgccactgg gaacatgaca atcacgtgca gctcaagtgg     1560

agtgtgttga ccagcaagac gggacccatt caggatcaca caggagatgg caacttcatc     1620

tattcccaag ctgacgaaaa tcagaagggc aaagtggctc gcctggtgag ccctgtggtt     1680

tattcccaga actctgccca ctgcatgacc ttctggtatc acatgtctgg gtcccacgtc     1740

ggcacactca gggtcaaact gcgctaccag aagccagagg agtacgatca gctggtctgg     1800

atggccattg gacaccaagg tgaccactgg aaggaagggc gtgtcttgct ccacaagtct     1860

ctgaaacttt atcaggtgat tttcgagggc gaaatcggaa aaggaaacct tggtgggatt     1920

gctgtggatg acattagtat taataaccac atttcacaag aagattgtgc aaaaccagca     1980

gacctggata aaaagaaccc agaaattaaa attgatgaaa cagggagcac gccaggatac     2040

gaaggtgaag gagaaggtga caagaacatc tccaggaagc caggcaatgt gttgaagacc     2100

ttagacccca gatctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     2160

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     2220

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     2280

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     2340

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     2400

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     2460

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     2520

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     2580

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     2640

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     2700

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc acgaggctct gcacaaccac     2760

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            2799


<210>  33
<211>  911
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val Glu Ala Pro Thr Ala 
                405                 410                 415     


Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp 
            420                 425                 430         


Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly 
        435                 440                 445             


Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr 
    450                 455                 460                 


Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp 
465                 470                 475                 480 


Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln 
                485                 490                 495     


Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His 
            500                 505                 510         


Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys 
        515                 520                 525             


Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser 
    530                 535                 540                 


Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly 
545                 550                 555                 560 


Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln 
                565                 570                 575     


Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly 
            580                 585                 590         


Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu 
        595                 600                 605             


Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile 
    610                 615                 620                 


Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp 
625                 630                 635                 640 


Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr 
                645                 650                 655     


Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys 
            660                 665                 670         


Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser Asp Lys Thr His 
        675                 680                 685             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    690                 695                 700                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
705                 710                 715                 720 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                725                 730                 735     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            740                 745                 750         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        755                 760                 765             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    770                 775                 780                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
785                 790                 795                 800 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                805                 810                 815     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            820                 825                 830         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        835                 840                 845             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    850                 855                 860                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
865                 870                 875                 880 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                885                 890                 895     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            900                 905                 910     


<210>  34
<211>  2799
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct gaagtggaag cccctacagc tggaccgacc     1320

actcccaacg ggaacttggt ggatgaatgt gatgacgacc aggccaactg ccacagtgga     1380

acaggtgatg acttccagct cacaggtggc accactgtgc tggccacaga aaagcccacg     1440

gtcatagaca gcaccataca atcagagttt ccaacatatg gttttaactg tgaatttggc     1500

tggggctctc acaagacctt ctgccactgg gaacatgaca atcacgtgca gctcaagtgg     1560

agtgtgttga ccagcaagac gggacccatt caggatcaca caggagatgg caacttcatc     1620

tattcccaag ctgacgaaaa tcagaagggc aaagtggctc gcctggtgag ccctgtggtt     1680

tattcccaga actctgccca ctgcatgacc ttctggtatc acatgtctgg gtcccacgtc     1740

ggcacactca gggtcaaact gcgctaccag aagccagagg agtacgatca gctggtctgg     1800

atggccattg gacaccaagg tgaccactgg aaggaagggc gtgtcttgct ccacaagtct     1860

ctgaaacttt atcaggtgat tttcgagggc gaaatcggaa aaggaaacct tggtgggatt     1920

gctgtggatg acattagtat taataaccac atttcacaag aagattgtgc aaaaccagca     1980

gacctggata aaaagaaccc agaaattaaa attgatgaaa cagggagcac gccaggatac     2040

gaaggtgaag gagaaggtga caagaacatc tccaggaagc caggcaatgt gttgaagacc     2100

ttagacccca gatctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     2160

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     2220

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     2280

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     2340

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     2400

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     2460

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     2520

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     2580

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     2640

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     2700

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc acgaggctct gcacaaccac     2760

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            2799


<210>  35
<211>  755
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Glu Val Glu 
                245                 250                 255     


Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu 
            260                 265                 270         


Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe 
        275                 280                 285             


Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val 
    290                 295                 300                 


Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys 
305                 310                 315                 320 


Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp 
                325                 330                 335     


Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro 
            340                 345                 350         


Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp 
        355                 360                 365             


Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr 
    370                 375                 380                 


Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly 
385                 390                 395                 400 


Ser His Val Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu 
                405                 410                 415     


Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His 
            420                 425                 430         


Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln 
        435                 440                 445             


Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala 
    450                 455                 460                 


Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala 
465                 470                 475                 480 


Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu 
                485                 490                 495     


Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn 
            500                 505                 510         


Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser 
        515                 520                 525             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    530                 535                 540                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
545                 550                 555                 560 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                565                 570                 575     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            580                 585                 590         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        595                 600                 605             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    610                 615                 620                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
625                 630                 635                 640 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                645                 650                 655     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            660                 665                 670         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        675                 680                 685             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    690                 695                 700                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
705                 710                 715                 720 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                725                 730                 735     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            740                 745                 750         


Pro Gly Lys 
        755 


<210>  36
<211>  2331
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aagaagtgga agcccctaca      840

gctggaccga ccactcccaa cgggaacttg gtggatgaat gtgatgacga ccaggccaac      900

tgccacagtg gaacaggtga tgacttccag ctcacaggtg gcaccactgt gctggccaca      960

gaaaagccca cggtcataga cagcaccata caatcagagt ttccaacata tggttttaac     1020

tgtgaatttg gctggggctc tcacaagacc ttctgccact gggaacatga caatcacgtg     1080

cagctcaagt ggagtgtgtt gaccagcaag acgggaccca ttcaggatca cacaggagat     1140

ggcaacttca tctattccca agctgacgaa aatcagaagg gcaaagtggc tcgcctggtg     1200

agccctgtgg tttattccca gaactctgcc cactgcatga ccttctggta tcacatgtct     1260

gggtcccacg tcggcacact cagggtcaaa ctgcgctacc agaagccaga ggagtacgat     1320

cagctggtct ggatggccat tggacaccaa ggtgaccact ggaaggaagg gcgtgtcttg     1380

ctccacaagt ctctgaaact ttatcaggtg attttcgagg gcgaaatcgg aaaaggaaac     1440

cttggtggga ttgctgtgga tgacattagt attaataacc acatttcaca agaagattgt     1500

gcaaaaccag cagacctgga taaaaagaac ccagaaatta aaattgatga aacagggagc     1560

acgccaggat acgaaggtga aggagaaggt gacaagaaca tctccaggaa gccaggcaat     1620

gtgttgaaga ccttagaccc cagatctgac aaaactcaca catgcccacc gtgcccagca     1680

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc     1740

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct     1800

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg     1860

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1920

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1980

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     2040

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     2100

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     2160

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     2220

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcacgaggct     2280

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              2331


<210>  37
<211>  227
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  38
<211>  853
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His 
        835                 840                 845             


His His His His His 
    850             


<210>  39
<211>  2625
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggccatcat catcatcatc attga                     2625


<210>  40
<211>  580
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His His 
                565                 570                 575     


His His His His 
            580 


<210>  41
<211>  1806
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgta gatctggatc caaggaaaac ttgtatttcc agggccatca tcatcatcat     1800

cattga                                                                1806


<210>  42
<211>  421
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His 
                405                 410                 415     


His His His His His 
            420     


<210>  43
<211>  1329
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcagatctgg atccaaggaa aacttgtatt tccagggcca tcatcatcat     1320

catcattga                                                             1329


<210>  44
<211>  262
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
                245                 250                 255     


His His His His His His 
            260         


<210>  45
<211>  852
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgagatc tggatccaag gaaaacttgt atttccaggg ccatcatcat      840

catcatcatt ga                                                          852


<210>  46
<211>  853
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His 
        835                 840                 845             


His His His His His 
    850             


<210>  47
<211>  2625
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggccatcat catcatcatc attga                     2625


<210>  48
<211>  580
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His His 
                565                 570                 575     


His His His His 
            580 


<210>  49
<211>  1806
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgta gatctggatc caaggaaaac ttgtatttcc agggccatca tcatcatcat     1800

cattga                                                                1806


<210>  50
<211>  421
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His 
                405                 410                 415     


His His His His His 
            420     


<210>  51
<211>  1329
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcagatctgg atccaaggaa aacttgtatt tccagggcca tcatcatcat     1320

catcattga                                                             1329


<210>  52
<211>  700
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val Glu Ala Pro Thr Ala 
                405                 410                 415     


Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp 
            420                 425                 430         


Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly 
        435                 440                 445             


Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr 
    450                 455                 460                 


Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp 
465                 470                 475                 480 


Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln 
                485                 490                 495     


Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His 
            500                 505                 510         


Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys 
        515                 520                 525             


Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser 
    530                 535                 540                 


Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly 
545                 550                 555                 560 


Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln 
                565                 570                 575     


Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly 
            580                 585                 590         


Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu 
        595                 600                 605             


Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile 
    610                 615                 620                 


Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp 
625                 630                 635                 640 


Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr 
                645                 650                 655     


Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys 
            660                 665                 670         


Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser Gly Ser Lys Glu 
        675                 680                 685             


Asn Leu Tyr Phe Gln Gly His His His His His His 
    690                 695                 700 


<210>  53
<211>  2166
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  53
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct gaagtggaag cccctacagc tggaccgacc     1320

actcccaacg ggaacttggt ggatgaatgt gatgacgacc aggccaactg ccacagtgga     1380

acaggtgatg acttccagct cacaggtggc accactgtgc tggccacaga aaagcccacg     1440

gtcatagaca gcaccataca atcagagttt ccaacatatg gttttaactg tgaatttggc     1500

tggggctctc acaagacctt ctgccactgg gaacatgaca atcacgtgca gctcaagtgg     1560

agtgtgttga ccagcaagac gggacccatt caggatcaca caggagatgg caacttcatc     1620

tattcccaag ctgacgaaaa tcagaagggc aaagtggctc gcctggtgag ccctgtggtt     1680

tattcccaga actctgccca ctgcatgacc ttctggtatc acatgtctgg gtcccacgtc     1740

ggcacactca gggtcaaact gcgctaccag aagccagagg agtacgatca gctggtctgg     1800

atggccattg gacaccaagg tgaccactgg aaggaagggc gtgtcttgct ccacaagtct     1860

ctgaaacttt atcaggtgat tttcgagggc gaaatcggaa aaggaaacct tggtgggatt     1920

gctgtggatg acattagtat taataaccac atttcacaag aagattgtgc aaaaccagca     1980

gacctggata aaaagaaccc agaaattaaa attgatgaaa cagggagcac gccaggatac     2040

gaaggtgaag gagaaggtga caagaacatc tccaggaagc caggcaatgt gttgaagacc     2100

ttagacccca gatctggatc caaggaaaac ttgtatttcc agggccatca tcatcatcat     2160

cattga                                                                2166


<210>  54
<211>  700
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val Glu Ala Pro Thr Ala 
                405                 410                 415     


Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp 
            420                 425                 430         


Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly 
        435                 440                 445             


Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr 
    450                 455                 460                 


Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp 
465                 470                 475                 480 


Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln 
                485                 490                 495     


Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His 
            500                 505                 510         


Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys 
        515                 520                 525             


Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser 
    530                 535                 540                 


Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly 
545                 550                 555                 560 


Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln 
                565                 570                 575     


Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly 
            580                 585                 590         


Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu 
        595                 600                 605             


Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile 
    610                 615                 620                 


Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp 
625                 630                 635                 640 


Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr 
                645                 650                 655     


Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys 
            660                 665                 670         


Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser Gly Ser Lys Glu 
        675                 680                 685             


Asn Leu Tyr Phe Gln Gly His His His His His His 
    690                 695                 700 


<210>  55
<211>  2166
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  55
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct gaagtggaag cccctacagc tggaccgacc     1320

actcccaacg ggaacttggt ggatgaatgt gatgacgacc aggccaactg ccacagtgga     1380

acaggtgatg acttccagct cacaggtggc accactgtgc tggccacaga aaagcccacg     1440

gtcatagaca gcaccataca atcagagttt ccaacatatg gttttaactg tgaatttggc     1500

tggggctctc acaagacctt ctgccactgg gaacatgaca atcacgtgca gctcaagtgg     1560

agtgtgttga ccagcaagac gggacccatt caggatcaca caggagatgg caacttcatc     1620

tattcccaag ctgacgaaaa tcagaagggc aaagtggctc gcctggtgag ccctgtggtt     1680

tattcccaga actctgccca ctgcatgacc ttctggtatc acatgtctgg gtcccacgtc     1740

ggcacactca gggtcaaact gcgctaccag aagccagagg agtacgatca gctggtctgg     1800

atggccattg gacaccaagg tgaccactgg aaggaagggc gtgtcttgct ccacaagtct     1860

ctgaaacttt atcaggtgat tttcgagggc gaaatcggaa aaggaaacct tggtgggatt     1920

gctgtggatg acattagtat taataaccac atttcacaag aagattgtgc aaaaccagca     1980

gacctggata aaaagaaccc agaaattaaa attgatgaaa cagggagcac gccaggatac     2040

gaaggtgaag gagaaggtga caagaacatc tccaggaagc caggcaatgt gttgaagacc     2100

ttagacccca gatctggatc caaggaaaac ttgtatttcc agggccatca tcatcatcat     2160

cattga                                                                2166


<210>  56
<211>  544
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Glu Val Glu 
                245                 250                 255     


Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu 
            260                 265                 270         


Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe 
        275                 280                 285             


Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val 
    290                 295                 300                 


Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys 
305                 310                 315                 320 


Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp 
                325                 330                 335     


Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro 
            340                 345                 350         


Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp 
        355                 360                 365             


Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr 
    370                 375                 380                 


Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly 
385                 390                 395                 400 


Ser His Val Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu 
                405                 410                 415     


Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His 
            420                 425                 430         


Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln 
        435                 440                 445             


Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala 
    450                 455                 460                 


Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala 
465                 470                 475                 480 


Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu 
                485                 490                 495     


Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn 
            500                 505                 510         


Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser 
        515                 520                 525             


Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His His His His His His 
    530                 535                 540                 


<210>  57
<211>  1698
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  57
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aagaagtgga agcccctaca      840

gctggaccga ccactcccaa cgggaacttg gtggatgaat gtgatgacga ccaggccaac      900

tgccacagtg gaacaggtga tgacttccag ctcacaggtg gcaccactgt gctggccaca      960

gaaaagccca cggtcataga cagcaccata caatcagagt ttccaacata tggttttaac     1020

tgtgaatttg gctggggctc tcacaagacc ttctgccact gggaacatga caatcacgtg     1080

cagctcaagt ggagtgtgtt gaccagcaag acgggaccca ttcaggatca cacaggagat     1140

ggcaacttca tctattccca agctgacgaa aatcagaagg gcaaagtggc tcgcctggtg     1200

agccctgtgg tttattccca gaactctgcc cactgcatga ccttctggta tcacatgtct     1260

gggtcccacg tcggcacact cagggtcaaa ctgcgctacc agaagccaga ggagtacgat     1320

cagctggtct ggatggccat tggacaccaa ggtgaccact ggaaggaagg gcgtgtcttg     1380

ctccacaagt ctctgaaact ttatcaggtg attttcgagg gcgaaatcgg aaaaggaaac     1440

cttggtggga ttgctgtgga tgacattagt attaataacc acatttcaca agaagattgt     1500

gcaaaaccag cagacctgga taaaaagaac ccagaaatta aaattgatga aacagggagc     1560

acgccaggat acgaaggtga aggagaaggt gacaagaaca tctccaggaa gccaggcaat     1620

gtgttgaaga ccttagaccc cagatctgga tccaaggaaa acttgtattt ccagggccat     1680

catcatcatc atcattga                                                   1698


<210>  58
<211>  853
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ala Lys Lys Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His 
        835                 840                 845             


His His His His His 
    850             


<210>  59
<211>  2625
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  59
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccattgccaa aaagaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggccatcat catcatcatc attga                     2625


<210>  60
<211>  853
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Lys Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His 
        835                 840                 845             


His His His His His 
    850             


<210>  61
<211>  2625
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagagaag      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggccatcat catcatcatc attga                     2625


<210>  62
<211>  853
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Lys Lys Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly His 
        835                 840                 845             


His His His His His 
    850             


<210>  63
<211>  2625
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggaaagaag      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggccatcat catcatcatc attga                     2625


<210>  64
<211>  771
<212>  PRT
<213>  human

<400>  64

Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      


Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     


Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     


Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         


Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His Asp Asn His His 
                565                 570                 575     


Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser 
            580                 585                 590         


Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp 
        595                 600                 605             


Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp 
    610                 615                 620                 


Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln 
625                 630                 635                 640 


Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe 
                645                 650                 655     


Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His 
            660                 665                 670         


Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr 
        675                 680                 685             


Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg 
    690                 695                 700                 


Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu 
705                 710                 715                 720 


Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg 
                725                 730                 735     


Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu 
            740                 745                 750         


Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro 
        755                 760                 765             


Arg Ser Val 
    770     


<210>  65
<211>  609
<212>  PRT
<213>  human

<400>  65

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Gly Thr Thr Val Leu 
            580                 585                 590         


Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ile 
        595                 600                 605             


Lys 
    


<210>  66
<211>  923
<212>  PRT
<213>  human

<400>  66

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  67
<211>  923
<212>  PRT
<213>  mus musculus

<400>  67

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Thr Leu Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Val Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Lys Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Ser Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Leu Gly Val Phe Ser Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Val Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Ala Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Thr Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Thr 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Ser Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Pro Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Ile Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Ser His Ala Gln Leu Arg 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Ser Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Val Val Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Thr Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Thr Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Pro Gln Ser Asn Tyr Ser Glu Ala 
        915                 920             


<210>  68
<211>  923
<212>  PRT
<213>  ratus norvegicus

<400>  68

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Thr Leu Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Val Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Phe Gly Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Ala Phe Thr Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Val Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Pro Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Ile Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Ser His Ala Gln Leu Arg 
            660                 665                 670         


Trp Arg Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Ser Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu His Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Val Val Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Pro Gln Glu Asp Cys Ala Lys Pro Thr Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Thr Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Glu Glu Gly Lys Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Pro Gln Ser Asn Tyr Ser Glu Ala 
        915                 920             


<210>  69
<211>  923
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (153)..(153)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (177)..(177)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (196)..(196)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (204)..(204)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (219)..(219)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (242)..(242)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (269)..(269)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (298)..(298)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (303)..(303)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (323)..(323)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (359)..(360)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (362)..(362)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (371)..(372)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (378)..(380)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (392)..(393)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (396)..(396)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (409)..(410)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (449)..(449)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (453)..(453)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (469)..(469)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (476)..(476)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (479)..(479)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (481)..(481)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (487)..(487)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (491)..(491)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (498)..(498)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (518)..(518)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (528)..(528)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (553)..(553)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (555)..(556)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (572)..(572)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (587)..(587)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (599)..(599)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (634)..(634)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (667)..(667)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (669)..(669)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (672)..(672)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (674)..(674)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (717)..(717)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (741)..(741)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (755)..(756)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (805)..(805)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (812)..(812)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (819)..(820)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (835)..(835)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (838)..(838)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (916)..(916)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (919)..(919)
<223>  Xaa can be any naturally occurring amino acid

<400>  69

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Xaa Leu Ala Leu Xaa Leu 
1               5                   10                  15      


Ala Xaa Ala Gly Ala Phe Arg Xaa Asp Lys Cys Gly Xaa Thr Ile Lys 
            20                  25                  30          


Ile Glu Xaa Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Xaa Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Xaa Asp Gly Glu Asn Glu Xaa 
                85                  90                  95      


Gly Xaa Xaa Xaa Gly Lys Phe Cys Gly Lys Ile Ala Pro Xaa Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Xaa Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Xaa Pro Xaa Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Xaa Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Xaa Asp Ser Asn Pro Pro Gly Gly Xaa Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Xaa Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Xaa Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Xaa Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Xaa Thr Asn Trp Ser Xaa Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Xaa Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Xaa Xaa Asp Xaa Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Xaa Xaa Lys Glu Gly Asn Lys Xaa Xaa Xaa Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Xaa Xaa Val Phe Xaa Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Xaa Xaa Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Xaa Ser Asn Gln Xaa Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Xaa Gly Trp Ala Leu Pro Pro Xaa Pro His Xaa Tyr 
465                 470                 475                 480 


Xaa Asn Glu Trp Leu Gln Xaa Asp Leu Gly Xaa Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Xaa Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Xaa Tyr Ser Asn Asn Gly Ser Asp Trp Lys Xaa 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Xaa Phe Xaa Xaa Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Xaa Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Xaa Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Xaa Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Xaa Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Xaa His Xaa Gln Leu Xaa 
            660                 665                 670         


Trp Xaa Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Xaa Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Xaa Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Xaa Xaa Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Xaa Gln Glu Asp Cys Ala Lys Xaa Asp Leu Asp Lys 
                805                 810                 815     


Lys Asn Xaa Xaa Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Xaa Glu Gly Xaa Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Xaa Gln Ser Xaa Tyr Ser Glu Ala 
        915                 920             


<210>  70
<211>  21
<212>  PRT
<213>  human

<400>  70

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala 
            20      


<210>  71
<211>  115
<212>  PRT
<213>  human

<400>  71

Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro 
1               5                   10                  15      


Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys Cys Glu Trp Leu Ile 
            20                  25                  30          


Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile Asn Phe Asn Pro His 
        35                  40                  45              


Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe 
    50                  55                  60                  


Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly Lys Phe Cys Gly Lys 
65                  70                  75                  80  


Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro Phe Leu Phe Ile Lys 
                85                  90                  95      


Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly Phe Ser Ile Arg Tyr 
            100                 105                 110         


Glu Leu Phe 
        115 


<210>  72
<211>  119
<212>  PRT
<213>  human

<400>  72

Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly 
1               5                   10                  15      


Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe 
            20                  25                  30          


Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu 
        35                  40                  45              


Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg 
    50                  55                  60                  


Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg 
65                  70                  75                  80  


Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile 
                85                  90                  95      


Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe 
            100                 105                 110         


Ser Ala Asn Tyr Ser Val Leu 
        115                 


<210>  73
<211>  150
<212>  PRT
<213>  human

<400>  73

Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln 
1               5                   10                  15      


Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser 
            20                  25                  30          


Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr 
        35                  40                  45              


Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala 
    50                  55                  60                  


Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr 
65                  70                  75                  80  


Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile 
                85                  90                  95      


Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn 
            100                 105                 110         


Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg 
        115                 120                 125             


Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg 
    130                 135                 140                 


Phe Glu Val Tyr Gly Cys 
145                 150 


<210>  74
<211>  153
<212>  PRT
<213>  human

<400>  74

Cys Ser Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln 
1               5                   10                  15      


Ile Thr Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile 
            20                  25                  30          


Arg Leu Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His 
        35                  40                  45              


Ser Tyr Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile 
    50                  55                  60                  


Val Arg Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val 
65                  70                  75                  80  


Phe Met Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp 
                85                  90                  95      


Lys Met Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly 
            100                 105                 110         


Asn Asn Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser 
        115                 120                 125             


Thr Arg Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu 
    130                 135                 140                 


Gly Leu Arg Met Glu Leu Leu Gly Cys 
145                 150             


<210>  75
<211>  167
<212>  PRT
<213>  human

<400>  75

Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe 
1               5                   10                  15      


Cys His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu 
            20                  25                  30          


Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe 
        35                  40                  45              


Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu 
    50                  55                  60                  


Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe 
65                  70                  75                  80  


Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu 
                85                  90                  95      


Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile 
            100                 105                 110         


Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys 
        115                 120                 125             


Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly 
    130                 135                 140                 


Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile 
145                 150                 155                 160 


Ser Gln Glu Asp Cys Ala Lys 
                165         


<210>  76
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  76

Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
1               5                   10  


<210>  77
<211>  40
<212>  PRT
<213>  human

<400>  77

Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu Glu Asn Tyr 
1               5                   10                  15      


Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp Lys Leu Asn 
            20                  25                  30          


Thr Gln Ser Thr Tyr Ser Glu Ala 
        35                  40  


<210>  78
<211>  127
<212>  PRT
<213>  human

<400>  78

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser 
        115                 120                 125         


<210>  79
<211>  127
<212>  PRT
<213>  human

<400>  79

Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro 
1               5                   10                  15      


Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro 
            20                  25                  30          


Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro 
        35                  40                  45              


Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu 
    50                  55                  60                  


Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys 
65                  70                  75                  80  


Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser 
                85                  90                  95      


Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala 
            100                 105                 110         


Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys 
        115                 120                 125         


<210>  80
<211>  153
<212>  PRT
<213>  human

<400>  80

Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile 
1               5                   10                  15      


Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg 
            20                  25                  30          


Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg 
        35                  40                  45              


Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val 
    50                  55                  60                  


Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val 
65                  70                  75                  80  


Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr 
                85                  90                  95      


Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro 
            100                 105                 110         


Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe 
        115                 120                 125             


Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe 
    130                 135                 140                 


Glu Val Tyr Gly Cys Lys Ile Thr Asp 
145                 150             


<210>  81
<211>  161
<212>  PRT
<213>  human

<400>  81

Tyr Pro Cys Ser Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp 
1               5                   10                  15      


Ser Gln Ile Thr Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu 
            20                  25                  30          


Asn Ile Arg Leu Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala 
        35                  40                  45              


Pro His Ser Tyr Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu 
    50                  55                  60                  


Lys Ile Val Arg Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn 
65                  70                  75                  80  


Lys Val Phe Met Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser 
                85                  90                  95      


Asp Trp Lys Met Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe 
            100                 105                 110         


Glu Gly Asn Asn Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala 
        115                 120                 125             


Leu Ser Thr Arg Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly 
    130                 135                 140                 


Gly Leu Gly Leu Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro 
145                 150                 155                 160 


Thr 
    


<210>  82
<211>  270
<212>  PRT
<213>  human

<400>  82

Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp 
1               5                   10                  15      


Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr 
            20                  25                  30          


Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser 
        35                  40                  45              


Thr Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly 
    50                  55                  60                  


Trp Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val 
65                  70                  75                  80  


Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp 
                85                  90                  95      


His Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln 
            100                 105                 110         


Lys Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn 
        115                 120                 125             


Ser Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val 
    130                 135                 140                 


Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp 
145                 150                 155                 160 


Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu 
                165                 170                 175     


Gly Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe 
            180                 185                 190         


Glu Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp 
        195                 200                 205             


Ile Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala 
    210                 215                 220                 


Asp Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser 
225                 230                 235                 240 


Thr Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg 
                245                 250                 255     


Lys Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile 
            260                 265                 270 


<210>  83
<211>  834
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  83

Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly Tyr 
1               5                   10                  15      


Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys Cys 
            20                  25                  30          


Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile Asn 
        35                  40                  45              


Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp Tyr 
    50                  55                  60                  


Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly Lys 
65                  70                  75                  80  


Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro Phe 
                85                  90                  95      


Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly Phe 
            100                 105                 110         


Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln Asn 
        115                 120                 125             


Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu Lys 
    130                 135                 140                 


Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys Met 
145                 150                 155                 160 


Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp Ser 
                165                 170                 175     


Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile Trp 
            180                 185                 190         


Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly Gln 
        195                 200                 205             


Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met Val 
    210                 215                 220                 


Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn Tyr 
225                 230                 235                 240 


Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu Ala 
                245                 250                 255     


Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala Ser 
            260                 265                 270         


Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn Tyr 
        275                 280                 285             


Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp Ile 
    290                 295                 300                 


Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr Gln 
305                 310                 315                 320 


Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr Tyr 
                325                 330                 335     


Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys Glu 
            340                 345                 350         


Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp Val 
        355                 360                 365             


Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg Ile 
    370                 375                 380                 


Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val Tyr 
385                 390                 395                 400 


Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met Val 
                405                 410                 415     


Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly Asp 
            420                 425                 430         


Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser Gly 
        435                 440                 445             


Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu Gln 
    450                 455                 460                 


Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln Gly 
465                 470                 475                 480 


Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile Gly 
                485                 490                 495     


Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser Lys 
            500                 505                 510         


Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro Glu 
        515                 520                 525             


Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr Pro 
    530                 535                 540                 


Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu Gly 
545                 550                 555                 560 


Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn 
                565                 570                 575     


Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr 
            580                 585                 590         


Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu 
        595                 600                 605             


Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr Tyr 
    610                 615                 620                 


Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys His 
625                 630                 635                 640 


Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser 
                645                 650                 655     


Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile Tyr 
            660                 665                 670         


Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val Ser 
        675                 680                 685             


Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp Tyr 
    690                 695                 700                 


His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg Tyr 
705                 710                 715                 720 


Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly His 
                725                 730                 735     


Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser Leu 
            740                 745                 750         


Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn Leu 
        755                 760                 765             


Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser Gln 
    770                 775                 780                 


Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu Ile 
785                 790                 795                 800 


Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly Glu 
                805                 810                 815     


Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr Leu 
            820                 825                 830         


Asp Pro 
        


<210>  84
<211>  2571
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  84
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagacccctg a              2571


<210>  85
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  85
gacggccagg tcatcactat tg                                                22


<210>  86
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  86
ccacaggatt ccatacccaa ga                                                22


<210>  87
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  87
gctcctgctc cgtagcctgc                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  88
tcggcgttgc tttcggtccc                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  89
gccctgagtc aagaggacag                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  90
ctcctaggcc cctcagaagt                                                   20


<210>  91
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  91
ccctcacact cagatcatct tct                                               23


<210>  92
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  92
gctacgacgt gggctacag                                                    19


<210>  93
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  93
ctggtacatc aggacctcac a                                                 21


<210>  94
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  94
gagctcctta acatgccctg                                                   20


<210>  95
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  95
agacaaagcc agagtccttc agaga                                             25


<210>  96
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  96
gccactcctt ctgtgactcg agc                                               23


<210>  97
<211>  40
<212>  PRT
<213>  human

<400>  97

Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu Glu Asn Tyr 
1               5                   10                  15      


Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp Lys Leu Asn 
            20                  25                  30          


Thr Gln Ser Thr Tyr Ser Glu Ala 
        35                  40  


<210>  98
<211>  64
<212>  PRT
<213>  human

<400>  98

Thr Ile Ile Ala Met Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys 
1               5                   10                  15      


Gly Val Val Leu Tyr Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg 
            20                  25                  30          


Asn Leu Ser Ala Leu Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val 
        35                  40                  45              


Lys Leu Lys Lys Asp Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
    50                  55                  60                  


<210>  99
<211>  19
<212>  PRT
<213>  human

<400>  99

Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser 
1               5                   10                  15      


Gly Ile Lys 
            


<210>  100
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  100

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro 
    850                 855     


<210>  101
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  101

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro 
    850                 855     


<210>  102
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  102

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Lys Lys 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro 
    850                 855     


<210>  103
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  103

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ala Lys Lys Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro 
    850                 855     


<210>  104
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  104

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Lys 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro 
    850                 855     


<210>  105
<211>  583
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  105

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys 
            580             


<210>  106
<211>  583
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  106

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys 
            580             


<210>  107
<211>  424
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  107

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys 
            420                 


<210>  108
<211>  424
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  108

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys 
            420                 


<210>  109
<211>  265
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  109

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu 
            260                 265 


<210>  110
<211>  642
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  110

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val 
            420                 425                 430         


Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp 
        435                 440                 445             


Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp 
    450                 455                 460                 


Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr 
465                 470                 475                 480 


Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn 
                485                 490                 495     


Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys His Trp Glu His 
            500                 505                 510         


Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly 
        515                 520                 525             


Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala 
    530                 535                 540                 


Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val Ser Pro Val Val 
545                 550                 555                 560 


Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp Tyr His Met Ser 
                565                 570                 575     


Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro 
            580                 585                 590         


Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp 
        595                 600                 605             


His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr 
    610                 615                 620                 


Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile 
625                 630                 635                 640 


Ala Val 
        


<210>  111
<211>  703
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  111

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val 
            420                 425                 430         


Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp 
        435                 440                 445             


Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp 
    450                 455                 460                 


Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr 
465                 470                 475                 480 


Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn 
                485                 490                 495     


Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys His Trp Glu His 
            500                 505                 510         


Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly 
        515                 520                 525             


Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala 
    530                 535                 540                 


Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val Ser Pro Val Val 
545                 550                 555                 560 


Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp Tyr His Met Ser 
                565                 570                 575     


Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro 
            580                 585                 590         


Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp 
        595                 600                 605             


His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr 
    610                 615                 620                 


Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile 
625                 630                 635                 640 


Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys 
                645                 650                 655     


Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp 
            660                 665                 670         


Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys 
        675                 680                 685             


Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr Leu Asp Pro 
    690                 695                 700             


<210>  112
<211>  547
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  112

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
        275                 280                 285             


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
    290                 295                 300                 


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
305                 310                 315                 320 


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
                325                 330                 335     


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
            340                 345                 350         


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
        355                 360                 365             


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
    370                 375                 380                 


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
385                 390                 395                 400 


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
                405                 410                 415     


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
            420                 425                 430         


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
        435                 440                 445             


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
    450                 455                 460                 


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
465                 470                 475                 480 


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
                485                 490                 495     


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
            500                 505                 510         


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
        515                 520                 525             


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
    530                 535                 540                 


Leu Asp Pro 
545         


<210>  113
<211>  703
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  113

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val 
            420                 425                 430         


Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp 
        435                 440                 445             


Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp 
    450                 455                 460                 


Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr 
465                 470                 475                 480 


Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn 
                485                 490                 495     


Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys His Trp Glu His 
            500                 505                 510         


Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly 
        515                 520                 525             


Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala 
    530                 535                 540                 


Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val Ser Pro Val Val 
545                 550                 555                 560 


Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp Tyr His Met Ser 
                565                 570                 575     


Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro 
            580                 585                 590         


Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp 
        595                 600                 605             


His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr 
    610                 615                 620                 


Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile 
625                 630                 635                 640 


Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys 
                645                 650                 655     


Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp 
            660                 665                 670         


Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys 
        675                 680                 685             


Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr Leu Asp Pro 
    690                 695                 700             


<210>  114
<211>  1085
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  114

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Arg Ser Asp Lys Thr His Thr Cys 
    850                 855                 860                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
865                 870                 875                 880 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                885                 890                 895     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            900                 905                 910         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        915                 920                 925             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    930                 935                 940                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
945                 950                 955                 960 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                965                 970                 975     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            980                 985                 990         


Arg Glu Glu Met Thr Lys Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys 
        995                 1000                 1005             


Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly 
    1010                 1015                 1020             


Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser 
    1025                 1030                 1035             


Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser 
    1040                 1045                 1050             


Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys Ser Val  Met His Glu 
    1055                 1060                 1065             


Ala Leu  His Asn His Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro 
    1070                 1075                 1080             


Gly Lys  
    1085 


<210>  115
<211>  1085
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (584)..(858)
<223>  Xaa can be any naturally occurring amino acid

<400>  115

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys 
    850                 855                 860                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
865                 870                 875                 880 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                885                 890                 895     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            900                 905                 910         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        915                 920                 925             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    930                 935                 940                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
945                 950                 955                 960 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                965                 970                 975     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            980                 985                 990         


Arg Glu Glu Met Thr Lys Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys 
        995                 1000                 1005             


Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly 
    1010                 1015                 1020             


Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser 
    1025                 1030                 1035             


Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser 
    1040                 1045                 1050             


Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys Ser Val  Met His Glu 
    1055                 1060                 1065             


Ala Leu  His Asn His Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro 
    1070                 1075                 1080             


Gly Lys  
    1085 


<210>  116
<211>  1085
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (425)..(858)
<223>  Xaa can be any naturally occurring amino acid

<400>  116

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys 
    850                 855                 860                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
865                 870                 875                 880 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                885                 890                 895     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            900                 905                 910         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        915                 920                 925             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    930                 935                 940                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
945                 950                 955                 960 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                965                 970                 975     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            980                 985                 990         


Arg Glu Glu Met Thr Lys Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys 
        995                 1000                 1005             


Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly 
    1010                 1015                 1020             


Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser 
    1025                 1030                 1035             


Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser 
    1040                 1045                 1050             


Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys Ser Val  Met His Glu 
    1055                 1060                 1065             


Ala Leu  His Asn His Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro 
    1070                 1075                 1080             


Gly Lys  
    1085 


<210>  117
<211>  1085
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (266)..(858)
<223>  Xaa can be any naturally occurring amino acid

<400>  117

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys 
    850                 855                 860                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
865                 870                 875                 880 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                885                 890                 895     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            900                 905                 910         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        915                 920                 925             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    930                 935                 940                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
945                 950                 955                 960 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                965                 970                 975     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            980                 985                 990         


Arg Glu Glu Met Thr Lys Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys 
        995                 1000                 1005             


Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly 
    1010                 1015                 1020             


Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser 
    1025                 1030                 1035             


Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser 
    1040                 1045                 1050             


Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys Ser Val  Met His Glu 
    1055                 1060                 1065             


Ala Leu  His Asn His Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro 
    1070                 1075                 1080             


Gly Lys  
    1085 


<210>  118
<211>  812
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  118

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Arg Ser Asp Lys Thr His Thr Cys Pro 
            580                 585                 590         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        595                 600                 605             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    610                 615                 620                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
625                 630                 635                 640 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                645                 650                 655     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            660                 665                 670         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        675                 680                 685             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    690                 695                 700                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
705                 710                 715                 720 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                725                 730                 735     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            740                 745                 750         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        755                 760                 765             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    770                 775                 780                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
785                 790                 795                 800 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                805                 810         


<210>  119
<211>  653
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  119

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Arg Ser Asp Lys Thr His Thr Cys 
            420                 425                 430         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650             


<210>  120
<211>  494
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  120

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Arg Ser Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 


<210>  121
<211>  1085
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  121

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Arg Ser Asp Lys Thr His Thr Cys 
    850                 855                 860                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
865                 870                 875                 880 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                885                 890                 895     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            900                 905                 910         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        915                 920                 925             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    930                 935                 940                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
945                 950                 955                 960 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                965                 970                 975     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            980                 985                 990         


Arg Glu Glu Met Thr Lys Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys 
        995                 1000                 1005             


Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly 
    1010                 1015                 1020             


Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser 
    1025                 1030                 1035             


Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser 
    1040                 1045                 1050             


Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys Ser Val  Met His Glu 
    1055                 1060                 1065             


Ala Leu  His Asn His Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro 
    1070                 1075                 1080             


Gly Lys  
    1085 


<210>  122
<211>  1085
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (584)..(858)
<223>  Xaa can be any naturally occurring amino acid

<400>  122

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys 
    850                 855                 860                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
865                 870                 875                 880 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                885                 890                 895     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            900                 905                 910         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        915                 920                 925             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    930                 935                 940                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
945                 950                 955                 960 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                965                 970                 975     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            980                 985                 990         


Arg Glu Glu Met Thr Lys Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys 
        995                 1000                 1005             


Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly 
    1010                 1015                 1020             


Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser 
    1025                 1030                 1035             


Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser 
    1040                 1045                 1050             


Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys Ser Val  Met His Glu 
    1055                 1060                 1065             


Ala Leu  His Asn His Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro 
    1070                 1075                 1080             


Gly Lys  
    1085 


<210>  123
<211>  1085
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (425)..(858)
<223>  Xaa can be any naturally occurring amino acid

<400>  123

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys 
    850                 855                 860                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
865                 870                 875                 880 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                885                 890                 895     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            900                 905                 910         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        915                 920                 925             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    930                 935                 940                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
945                 950                 955                 960 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                965                 970                 975     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            980                 985                 990         


Arg Glu Glu Met Thr Lys Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys 
        995                 1000                 1005             


Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly 
    1010                 1015                 1020             


Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser 
    1025                 1030                 1035             


Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser 
    1040                 1045                 1050             


Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys Ser Val  Met His Glu 
    1055                 1060                 1065             


Ala Leu  His Asn His Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro 
    1070                 1075                 1080             


Gly Lys  
    1085 


<210>  124
<211>  812
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  124

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Arg Ser Asp Lys Thr His Thr Cys Pro 
            580                 585                 590         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        595                 600                 605             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    610                 615                 620                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
625                 630                 635                 640 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                645                 650                 655     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            660                 665                 670         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        675                 680                 685             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    690                 695                 700                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
705                 710                 715                 720 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                725                 730                 735     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            740                 745                 750         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        755                 760                 765             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    770                 775                 780                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
785                 790                 795                 800 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                805                 810         


<210>  125
<211>  653
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  125

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Arg Ser Asp Lys Thr His Thr Cys 
            420                 425                 430         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650             


<210>  126
<211>  1086
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  126

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Val Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Lys Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Ser Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Leu Gly Val Phe Ser Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Val Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Ala Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Thr Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Thr 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Ser Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Pro Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Ile Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Ser His Ala Gln Leu Arg 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Ser Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Val Val Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Thr Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Thr Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Val Ser Ser Thr Met Val Arg Ser 
    850                 855                 860                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
865                 870                 875                 880 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                885                 890                 895     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            900                 905                 910         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        915                 920                 925             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    930                 935                 940                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
945                 950                 955                 960 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                965                 970                 975     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            980                 985                 990         


Pro Lys Glu Gln Met Ala Lys Asp  Lys Val Ser Leu Thr  Cys Met Ile 
        995                 1000                 1005             


Thr Asp  Phe Phe Pro Glu Asp  Ile Thr Val Glu Trp  Gln Trp Asn 
    1010                 1015                 1020             


Gly Gln  Pro Ala Glu Asn Tyr  Lys Asn Thr Gln Pro  Ile Met Asp 
    1025                 1030                 1035             


Thr Asp  Gly Ser Tyr Phe Val  Tyr Ser Lys Leu Asn  Val Gln Lys 
    1040                 1045                 1050             


Ser Asn  Trp Glu Ala Gly Asn  Thr Phe Thr Cys Ser  Val Leu His 
    1055                 1060                 1065             


Glu Gly  Leu His Asn His His  Thr Glu Lys Ser Leu  Ser His Ser 
    1070                 1075                 1080             


Pro Gly  Lys 
    1085     


<210>  127
<211>  813
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  127

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Val Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Lys Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Ser Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Leu Gly Val Phe Ser Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Val Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Ala Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Thr Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Thr 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Ser Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Val Ser Ser Thr Met Val Arg Ser Gly 
            580                 585                 590         


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
        595                 600                 605             


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
    610                 615                 620                 


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
625                 630                 635                 640 


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
                645                 650                 655     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
            660                 665                 670         


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
        675                 680                 685             


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    690                 695                 700                 


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
705                 710                 715                 720 


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
                725                 730                 735     


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
            740                 745                 750         


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
        755                 760                 765             


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
    770                 775                 780                 


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
785                 790                 795                 800 


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
                805                 810             


<210>  128
<211>  654
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  128

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Val Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Lys Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Ser Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Leu Gly Val Phe Ser Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Val Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Val Ser Ser Thr Met Val Arg Ser 
            420                 425                 430         


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
        435                 440                 445             


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
    450                 455                 460                 


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
465                 470                 475                 480 


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
                485                 490                 495     


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
            500                 505                 510         


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
        515                 520                 525             


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    530                 535                 540                 


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
545                 550                 555                 560 


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
                565                 570                 575     


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
            580                 585                 590         


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
        595                 600                 605             


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
    610                 615                 620                 


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
625                 630                 635                 640 


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
                645                 650                 


