                         SEQUENCE LISTING

<110>  Tufts University
       Kumar-Singh, Rajendra
       Leaderer, Derek
       Cashman, Siobhan
 
<120>  Compositions, methods and kits for treating complement related 
       disorders

<130>  34724-161

<150>  62/043,084
<151>  2014-08-28

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  2067
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The nucleotide sequence was designed and synthesized

<400>  1
atgggaatcc aaggagggtc tgtcctgttc gggctgctgc tcgtcctggc tgtcttctgc       60

cattcaggtc atagcggatg tgaggagcca ccaacatttg aagctatgga gctcattggt      120

aaaccaaaac cctactatga gattggtgaa cgagtagatt ataagtgtaa aaaaggatac      180

ttctatatac ctcctcttgc cacccatact atttgtgatc ggaatcatac atggctacct      240

gtctcagatg acgcctgtta tagagaaaca tgtccatata tacgggatcc tttaaatggc      300

caagcagtcc ctgcaaatgg gacttacgag tttggttatc agatgcactt tatttgtaat      360

gagggttatt acttaattgg tgaagaaatt ctatattgtg aacttaaagg atcagtagca      420

atttggagcg gtaagccccc aatatgtgaa aaggttttgt gtacaccacc tccaaaaata      480

aaaaatggaa aacacacctt tagtgaagta gaagtatttg agtatcttga tgcagtaact      540

tatagttgtg atcctgcacc tggaccagat ccattttcac ttattggaga gagcacgatt      600

tattgtggtg acaattcagt gtggagtcgt gctgctccag agtgtaaagt ggtcaaatgt      660

cgatttccag tagtcgaaaa tggaaaacag atatcaggat ttggaaaaaa attttactac      720

aaagcaacag ttatgtttga atgcgataag ggtttttacc tcgatggcag cgacacaatt      780

gtctgtgaca gtaacagtac ttgggatccc ccagttccaa agtgtcttaa agtgggaggc      840

ggaggtggag gtgactgtgg ccttccccca gatgtaccta atgcccagcc agctttggaa      900

ggccgtacaa gttttcccga ggatactgta ataacgtaca aatgtgaaga aagctttgtg      960

aaaattcctg gcgagaagga ctcagtgatc tgccttaagg gcagtcaatg gtcagatatt     1020

gaagagttct gcaatcgtag ctgcgaggtg ccaacaaggc taaattctgc atccctcaaa     1080

cagccttata tcactcagaa ttattttcca gtcggtactg ttgtggaata tgagtgccgt     1140

ccaggttaca gaagagaacc ttctctatca ccaaaactaa cttgccttca gaatttaaaa     1200

tggtccacag cagtcgaatt ttgtaaaaag aaatcatgcc ctaatccggg agaaatacga     1260

aatggtcaga ttgatgtacc aggtggcata ttatttggtg caaccatctc cttctcatgt     1320

aacacagggt acaaattatt tggctcgact tctagttttt gtcttatttc aggcagctct     1380

gtccagtgga gtgacccgtt gccagagtgc agagaaattt attgtccagc accaccacaa     1440

attgacaatg gaataattca aggggaacgt gaccattatg gatatagaca gtctgtaacg     1500

tatgcatgta ataaaggatt caccatgatt ggagagcact ctatttattg tactgtgaat     1560

aatgatgaag gagagtggag tggcccacca cctgaatgca gaggaaaatc tctaacttcc     1620

aaggtcccac caacagttca gaaacctacc acagtaaatg ttccaactac agaagtctca     1680

ccaacttctc agaaaaccac cacaaaaacc accacaccaa atgctcaagc aacacggagt     1740

acacctgttt ccaggacaac caagcatttt catgaaacaa ccccaaataa aggaagtgga     1800

accacttcag gtactaccgg cggaggtgga ggtctgcagt gctacaactg tcctaaccca     1860

actgctgact gcaaaacagc cgtcaattgt tcatctgatt ttgatgcgtg tctcattacc     1920

aaagctgggt tacaagtgta taacaagtgt tggaagtttg agcattgcaa tttcaacgac     1980

gtcacaaccc gcttgaggga aaatgagcta acgtactact gctgcaagaa ggacctgtgt     2040

aactttaacg aacagcttga atgatga                                         2067


<210>  2
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid sequence was designed and synthesized

<400>  2

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Gly Cys Glu Glu Pro Pro Thr 
            20                  25                  30          


Phe Glu Ala Met Glu Leu Ile Gly Lys Pro Lys Pro Tyr Tyr Glu Ile 
        35                  40                  45              


Gly Glu Arg Val Asp Tyr Lys Cys Lys Lys Gly Tyr Phe Tyr Ile Pro 
    50                  55                  60                  


Pro Leu Ala Thr His Thr Ile Cys Asp Arg Asn His Thr Trp Leu Pro 
65                  70                  75                  80  


Val Ser Asp Asp Ala Cys Tyr Arg Glu Thr Cys Pro Tyr Ile Arg Asp 
                85                  90                  95      


Pro Leu Asn Gly Gln Ala Val Pro Ala Asn Gly Thr Tyr Glu Phe Gly 
            100                 105                 110         


Tyr Gln Met His Phe Ile Cys Asn Glu Gly Tyr Tyr Leu Ile Gly Glu 
        115                 120                 125             


Glu Ile Leu Tyr Cys Glu Leu Lys Gly Ser Val Ala Ile Trp Ser Gly 
    130                 135                 140                 


Lys Pro Pro Ile Cys Glu Lys Val Leu Cys Thr Pro Pro Pro Lys Ile 
145                 150                 155                 160 


Lys Asn Gly Lys His Thr Phe Ser Glu Val Glu Val Phe Glu Tyr Leu 
                165                 170                 175     


Asp Ala Val Thr Tyr Ser Cys Asp Pro Ala Pro Gly Pro Asp Pro Phe 
            180                 185                 190         


Ser Leu Ile Gly Glu Ser Thr Ile Tyr Cys Gly Asp Asn Ser Val Trp 
        195                 200                 205             


Ser Arg Ala Ala Pro Glu Cys Lys Val Val Lys Cys Arg Phe Pro Val 
    210                 215                 220                 


Val Glu Asn Gly Lys Gln Ile Ser Gly Phe Gly Lys Lys Phe Tyr Tyr 
225                 230                 235                 240 


Lys Ala Thr Val Met Phe Glu Cys Asp Lys Gly Phe Tyr Leu Asp Gly 
                245                 250                 255     


Ser Asp Thr Ile Val Cys Asp Ser Asn Ser Thr Trp Asp Pro Pro Val 
            260                 265                 270         


Pro Lys Cys Leu Lys Val Gly Gly Gly Gly Gly Gly Asp Cys Gly Leu 
        275                 280                 285             


Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser 
    290                 295                 300                 


Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val 
305                 310                 315                 320 


Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln 
                325                 330                 335     


Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Thr 
            340                 345                 350         


Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr 
        355                 360                 365             


Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg 
    370                 375                 380                 


Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys 
385                 390                 395                 400 


Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro 
                405                 410                 415     


Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe 
            420                 425                 430         


Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly 
        435                 440                 445             


Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser 
    450                 455                 460                 


Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln 
465                 470                 475                 480 


Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg 
                485                 490                 495     


Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu 
            500                 505                 510         


His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly 
        515                 520                 525             


Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro 
    530                 535                 540                 


Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser 
545                 550                 555                 560 


Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln 
                565                 570                 575     


Ala Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu 
            580                 585                 590         


Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Gly Gly 
        595                 600                 605             


Gly Gly Gly Leu Gln Cys Tyr Asn Cys Pro Asn Pro Thr Ala Asp Cys 
    610                 615                 620                 


Lys Thr Ala Val Asn Cys Ser Ser Asp Phe Asp Ala Cys Leu Ile Thr 
625                 630                 635                 640 


Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys Trp Lys Phe Glu His Cys 
                645                 650                 655     


Asn Phe Asn Asp Val Thr Thr Arg Leu Arg Glu Asn Glu Leu Thr Tyr 
            660                 665                 670         


Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe Asn Glu Gln Leu Glu 
        675                 680                 685         


<210>  3
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The nucleotide sequence was designed and synthesized

<400>  3
atgggaatcc aaggagggtc tgtcctgttc gggctgctgc tcgtcctggc tgtcttctgc       60

cattcaggtc atagcggagg tgactgtggc cttcccccag atgtacctaa tgcccagcca      120

gctttggaag gccgtacaag ttttcccgag gatactgtaa taacgtacaa atgtgaagaa      180

agctttgtga aaattcctgg cgagaaggac tcagtgatct gccttaaggg cagtcaatgg      240

tcagatattg aagagttctg caatcgtagc tgcgaggtgc caacaaggct aaattctgca      300

tccctcaaac agccttatat cactcagaat tattttccag tcggtactgt tgtggaatat      360

gagtgccgtc caggttacag aagagaacct tctctatcac caaaactaac ttgccttcag      420

aatttaaaat ggtccacagc agtcgaattt tgtaaaaaga aatcatgccc taatccggga      480

gaaatacgaa atggtcagat tgatgtacca ggtggcatat tatttggtgc aaccatctcc      540

ttctcatgta acacagggta caaattattt ggctcgactt ctagtttttg tcttatttca      600

ggcagctctg tccagtggag tgacccgttg ccagagtgca gagaaattta ttgtccagca      660

ccaccacaaa ttgacaatgg aataattcaa ggggaacgtg accattatgg atatagacag      720

tctgtaacgt atgcatgtaa taaaggattc accatgattg gagagcactc tatttattgt      780

actgtgaata atgatgaagg agagtggagt ggcccaccac ctgaatgcag aggaaaatct      840

ctaacttcca aggtcccacc aacagttcag aaacctacca cagtaaatgt tccaactaca      900

gaagtctcac caacttctca gaaaaccacc acaaaaacca ccacaccaaa tgctcaagca      960

acacggagta cacctgtttc caggacaacc aagcattttc atgaaacaac cccaaataaa     1020

ggaagtggaa ccacttcagg tactaccggc ggaggtggag gtctgcagtg ctacaactgt     1080

cctaacccaa ctgctgactg caaaacagcc gtcaattgtt catctgattt tgatgcgtgt     1140

ctcattacca aagctgggtt acaagtgtat aacaagtgtt ggaagtttga gcattgcaat     1200

ttcaacgacg tcacaacccg cttgagggaa aatgagctaa cgtactactg ctgcaagaag     1260

gacctgtgta actttaacga acagcttgaa tgatga                               1296


<210>  4
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid sequence was designed and synthesized

<400>  4

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Gly Gly Asp Cys Gly Leu Pro 
            20                  25                  30          


Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser Phe 
        35                  40                  45              


Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val Lys 
    50                  55                  60                  


Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln Trp 
65                  70                  75                  80  


Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Thr Arg 
                85                  90                  95      


Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr Phe 
            100                 105                 110         


Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg Arg 
        115                 120                 125             


Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys Trp 
    130                 135                 140                 


Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro Gly 
145                 150                 155                 160 


Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe Gly 
                165                 170                 175     


Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly Ser 
            180                 185                 190         


Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser Asp 
        195                 200                 205             


Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln Ile 
    210                 215                 220                 


Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg Gln 
225                 230                 235                 240 


Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu His 
                245                 250                 255     


Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly Pro 
            260                 265                 270         


Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro Thr 
        275                 280                 285             


Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser Pro 
    290                 295                 300                 


Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln Ala 
305                 310                 315                 320 


Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu Thr 
                325                 330                 335     


Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Gly Gly Gly 
            340                 345                 350         


Gly Gly Leu Gln Cys Tyr Asn Cys Pro Asn Pro Thr Ala Asp Cys Lys 
        355                 360                 365             


Thr Ala Val Asn Cys Ser Ser Asp Phe Asp Ala Cys Leu Ile Thr Lys 
    370                 375                 380                 


Ala Gly Leu Gln Val Tyr Asn Lys Cys Trp Lys Phe Glu His Cys Asn 
385                 390                 395                 400 


Phe Asn Asp Val Thr Thr Arg Leu Arg Glu Asn Glu Leu Thr Tyr Tyr 
                405                 410                 415     


Cys Cys Lys Lys Asp Leu Cys Asn Phe Asn Glu Gln Leu Glu 
            420                 425                 430 


<210>  5
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid sequence was designed and synthesized

<400>  5

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Gly Gly Gly Gly Gly Cys Glu Glu Pro Pro Thr 
            100                 105                 110         


Phe Glu Ala Met Glu Leu Ile Gly Lys Pro Lys Pro Tyr Tyr Glu Ile 
        115                 120                 125             


Gly Glu Arg Val Asp Tyr Lys Cys Lys Lys Gly Tyr Phe Tyr Ile Pro 
    130                 135                 140                 


Pro Leu Ala Thr His Thr Ile Cys Asp Arg Asn His Thr Trp Leu Pro 
145                 150                 155                 160 


Val Ser Asp Asp Ala Cys Tyr Arg Glu Thr Cys Pro Tyr Ile Arg Asp 
                165                 170                 175     


Pro Leu Asn Gly Gln Ala Val Pro Ala Asn Gly Thr Tyr Glu Phe Gly 
            180                 185                 190         


Tyr Gln Met His Phe Ile Cys Asn Glu Gly Tyr Tyr Leu Ile Gly Glu 
        195                 200                 205             


Glu Ile Leu Tyr Cys Glu Leu Lys Gly Ser Val Ala Ile Trp Ser Gly 
    210                 215                 220                 


Lys Pro Pro Ile Cys Glu Lys Val Leu Cys Thr Pro Pro Pro Lys Ile 
225                 230                 235                 240 


Lys Asn Gly Lys His Thr Phe Ser Glu Val Glu Val Phe Glu Tyr Leu 
                245                 250                 255     


Asp Ala Val Thr Tyr Ser Cys Asp Pro Ala Pro Gly Pro Asp Pro Phe 
            260                 265                 270         


Ser Leu Ile Gly Glu Ser Thr Ile Tyr Cys Gly Asp Asn Ser Val Trp 
        275                 280                 285             


Ser Arg Ala Ala Pro Glu Cys Lys Val Val Lys Cys Arg Phe Pro Val 
    290                 295                 300                 


Val Glu Asn Gly Lys Gln Ile Ser Gly Phe Gly Lys Lys Phe Tyr Tyr 
305                 310                 315                 320 


Lys Ala Thr Val Met Phe Glu Cys Asp Lys Gly Phe Tyr Leu Asp Gly 
                325                 330                 335     


Ser Asp Thr Ile Val Cys Asp Ser Asn Ser Thr Trp Asp Pro Pro Val 
            340                 345                 350         


Pro Lys Cys Leu Lys Val Gly Gly Gly Gly Gly Gly Asp Cys Gly Leu 
        355                 360                 365             


Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser 
    370                 375                 380                 


Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val 
385                 390                 395                 400 


Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln 
                405                 410                 415     


Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Thr 
            420                 425                 430         


Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr 
        435                 440                 445             


Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg 
    450                 455                 460                 


Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys 
465                 470                 475                 480 


Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro 
                485                 490                 495     


Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe 
            500                 505                 510         


Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly 
        515                 520                 525             


Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser 
    530                 535                 540                 


Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln 
545                 550                 555                 560 


Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg 
                565                 570                 575     


Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu 
            580                 585                 590         


His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly 
        595                 600                 605             


Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro 
    610                 615                 620                 


Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser 
625                 630                 635                 640 


Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln 
                645                 650                 655     


Ala Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu 
            660                 665                 670         


Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr 
        675                 680                 685     


