                         SEQUENCE LISTING

<110>  Yale University
       HANSEN, JAMES E.
       WEISBART, RICHARD H.
       NOBLE, PHILIP W.
 
<120>  MULTIVALENT FRAGMENTS OF ANTIBODY 3E10 AND METHODS OF USE THEREOF

<130>  YU 6284

<150>  62/043,228
<151>  2014-08-28

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - heavy chain variable region

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro 
        115         


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  4

Gly Gln Ser Ser Arg Ser Ser 
1               5           


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  5

Gly Gln Ser Ser Arg Ser Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  6

Gly Ser Gly Ser 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  7

Gly Gly Gly Ser 
1               


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  8

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - protein transduction domain

<400>  10

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - protein transduction domain

<400>  11

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - protein transduction domain

<400>  12

Arg Arg Arg Arg Arg Arg Arg 
1               5           


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - protein transduction domain

<400>  13

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  14
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - protein transduction domain

<400>  14

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  15
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - protein transduction domain

<400>  15

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu Ala 
            20                  25                  


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - protein transduction domain

<400>  16

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - nuclear localization signal

<400>  17

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - nuclear localization signal

<400>  18

Gly Lys Lys Arg Ser Lys Val 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - nuclear localization signal

<400>  19

Lys Ser Arg Lys Arg Lys Leu 
1               5           


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide - nuclear localization signal

<400>  20

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Asp Lys 
            


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - nuclear localization signal

<400>  21

Arg Lys Lys Arg Lys Thr Glu Glu Glu Ser Pro Leu Lys Asp Lys Ala 
1               5                   10                  15      


Lys Lys Ser Lys 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - nuclear localization signal

<400>  22

Lys Asp Cys Val Met Asn Lys His His Arg Asn Arg Cys Gln Tyr Cys 
1               5                   10                  15      


Arg Leu Gln Arg 
            20  


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - nuclear localization signal

<400>  23

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - nuclear localization signal

<400>  24

Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210>  25
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - single chain variable fragment

<400>  25

Ala Gly Ile His Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
1               5                   10                  15      


Val Ser Leu Gly Gln Arg Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
            20                  25                  30          


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly 
    50                  55                  60                  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    130                 135                 140                 


Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser 
145                 150                 155                 160 


Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro 
                165                 170                 175     


Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr 
            180                 185                 190         


Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        195                 200                 205             


Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu 
    210                 215                 220                 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Leu Glu Gln Lys Leu 
                245                 250                 255     


Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His His His His His 
            260                 265                 270         


His 
    


<210>  26
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - di-single chain variable fragment

<400>  26

Ala Gly Ile His Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
1               5                   10                  15      


Val Ser Leu Gly Gln Arg Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
            20                  25                  30          


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly 
    50                  55                  60                  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    130                 135                 140                 


Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser 
145                 150                 155                 160 


Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro 
                165                 170                 175     


Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr 
            180                 185                 190         


Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        195                 200                 205             


Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu 
    210                 215                 220                 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
                245                 250                 255     


Pro Ser Val Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile 
            260                 265                 270         


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
        275                 280                 285             


Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser 
    290                 295                 300                 


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
305                 310                 315                 320 


Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
                325                 330                 335     


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu 
            340                 345                 350         


Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro 
        355                 360                 365             


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
    370                 375                 380                 


Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly 
                405                 410                 415     


Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 
            420                 425                 430         


Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp 
        435                 440                 445             


Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr 
    450                 455                 460                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
465                 470                 475                 480 


Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr 
                485                 490                 495     


Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            500                 505                 510         


Leu Thr Val Ser Ser Leu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
        515                 520                 525             


Asn Ser Ala Val Asp His His His His His His 
    530                 535                 


<210>  27
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - tri-single chain variable fragment

<400>  27

Ala Gly Ile His Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
1               5                   10                  15      


Val Ser Leu Gly Gln Arg Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
            20                  25                  30          


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly 
    50                  55                  60                  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    130                 135                 140                 


Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser 
145                 150                 155                 160 


Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro 
                165                 170                 175     


Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr 
            180                 185                 190         


Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        195                 200                 205             


Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu 
    210                 215                 220                 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
                245                 250                 255     


Pro Ser Val Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile 
            260                 265                 270         


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
        275                 280                 285             


Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser 
    290                 295                 300                 


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
305                 310                 315                 320 


Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
                325                 330                 335     


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu 
            340                 345                 350         


Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro 
        355                 360                 365             


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
    370                 375                 380                 


Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly 
                405                 410                 415     


Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 
            420                 425                 430         


Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp 
        435                 440                 445             


Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr 
    450                 455                 460                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
465                 470                 475                 480 


Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr 
                485                 490                 495     


Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            500                 505                 510         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        515                 520                 525             


Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    530                 535                 540                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Thr Ile Ser Cys Arg Ala 
545                 550                 555                 560 


Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln 
                565                 570                 575     


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr 
            580                 585                 590         


Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        595                 600                 605             


Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr 
    610                 615                 620                 


Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly 
625                 630                 635                 640 


Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
            660                 665                 670         


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser 
        675                 680                 685             


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val 
    690                 695                 700                 


Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser 
705                 710                 715                 720 


Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr 
                725                 730                 735     


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Thr Ser 
            740                 745                 750         


Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Leu 
        755                 760                 765             


Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Leu 
    770                 775                 780                 


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His 
785                 790                 795                 800 


His His His His His 
                805 


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  28

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


