                         SEQUENCE LISTING

<110>  AMGEN INC.
       O'Neill, et al.
 
<120>  VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE 
       (TIMP-3), COMPOSITIONS AND METHODS

<130>  01017/49907

<150>  62/042,574
<151>  2014-08-27

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  633
<212>  DNA
<213>  Homo sapiens

<400>  1
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccc                                   633


<210>  2
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 
1               5                   10                  15      


Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210>  3
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Asn Phe Thr Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Asn Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  4
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Asn Phe Thr Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  5
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  5

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Asn Phe Thr Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  6
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  7
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  8
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  8

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  9
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  9

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  10
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  11
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  12
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  13
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  13

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  14
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Asn Phe Thr Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  15
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  16
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  17
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  18
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  19
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Asn Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  20
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Asn Phe Thr Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  21
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  21

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Asn Phe Thr Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Asn Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  22
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  22

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Asn Phe Thr Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  23
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  23

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Asn Phe Thr Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  24
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  24

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Asn Phe Thr Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Asn Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  25
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  26
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  26

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210>  27
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  27
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaatgtgac ggggaagaag ctggtaaagg aggggaactt caccacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggacaatct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  28
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  28
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaatgtgac ggggaagaag ctggtaaagg aggggaactt caccacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  29
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  29
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaatgtgac ggggaagaag ctggtaaagg aggggaactt caccacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  30
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  30
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaatgtgac ggggaagaag ctggtaaagg aggggcccaa cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  31
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  31
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaatgtgac ggggaagaag ctggtaaagg aggggcccaa cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  32
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  32
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaatgtgac ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc caatgtgacg      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  33
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  33
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaatgtgac ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  34
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  34
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaatgtgac ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  35
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  35
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaatgtgac ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  36
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  36
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccagcgtggt ggggaagaag ctggtaaagg aggggcccaa cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  37
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  37
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccagcgtggt ggggaagaag ctggtaaagg aggggcccaa cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc caatgtgacg      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  38
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  38
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaat ctgacaaagg aggggaactt caccacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  39
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  39
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaat ctgacaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc caatgtgacg      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  40
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  40
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaat ctgacaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  41
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  41
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaat ctgacaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  42
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  42
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaat ctgacaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  43
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  43
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaat ctgacaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggacaatct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  44
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  44
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggaactt caccacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc caatgtgacg      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  45
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  45
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggaactt caccacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggacaatct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  46
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  46
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggaactt caccacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  47
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  47
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggaactt caccacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc caatgtgacg      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  48
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  48
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggaactt caccacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggacaatct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  49
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  49
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc caatgtgacg      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccccaccacc atcaccatca t               651


<210>  50
<211>  2391
<212>  DNA
<213>  Homo sapiens

<400>  50
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc caatgtgacg      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac cccgatgcac acaagagtga ggttgctcat      660

cgatttaaag atttgggaga agaaaatttc aaagccttgg tgttgattgc ctttgctcag      720

tatcttcagc agtgtccatt tgaagatcat gtaaaattag tgaatgaagt aactgaattt      780

gcaaaaacat gtgttgctga tgagtcagct gaaaattgtg acaaatcact tcataccctt      840

tttggagaca aattatgcac agttgcaact cttcgtgaaa cctatggtga aatggctgac      900

tgctgtgcaa aacaagaacc tgagagaaat gaatgcttct tgcaacacaa agatgacaac      960

ccaaacctcc cccgattggt gagaccagag gttgatgtga tgtgcactgc ttttcatgac     1020

aatgaagaga catttttgaa aaaatactta tatgaaattg ccagaagaca tccttacttt     1080

tatgccccgg aactcctttt ctttgctaaa aggtataaag ctgcttttac agaatgttgc     1140

caagctgctg ataaagctgc ctgcctgttg ccaaagctcg atgaacttcg ggatgaaggg     1200

aaggcttcgt ctgccaaaca gagactcaag tgtgccagtc tccaaaaatt tggagaaaga     1260

gctttcaaag catgggcagt agctcgcctg agccagagat ttcccaaagc tgagtttgca     1320

gaagtttcca agttagtgac agatcttacc aaagtccaca cggaatgctg ccatggagat     1380

ctgcttgaat gtgctgatga cagggcggac cttgccaagt atatctgtga aaatcaagat     1440

tcgatctcca gtaaactgaa ggaatgctgt gaaaaacctc tgttggaaaa atcccactgc     1500

attgccgaag tggaaaatga tgagatgcct gctgacttgc cttcattagc tgctgatttt     1560

gttgaaagta aggatgtttg caaaaactat gctgaggcaa aggatgtctt cctgggcatg     1620

tttttgtatg aatatgcaag aaggcatcct gattactctg tcgtgctgct gctgagactt     1680

gccaagacat atgaaaccac tctagagaag tgctgtgccg ctgcagatcc tcatgaatgc     1740

tatgccaaag tgttcgatga atttaaacct cttgtggaag agcctcagaa tttaatcaaa     1800

caaaattgtg agctttttga gcagcttgga gagtacaaat tccagaatgc gctattagtt     1860

cgttacacca agaaagtacc ccaactgtca actccaactc ttatcgaggt ctcaagaaac     1920

ctaggaaaag tgggcagcaa atgttgtaaa catcctgaag caaaaagaat gccctgtgca     1980

gaagactatc tatccgtggt cctgaaccag ttatgtgtgt tgcatgagaa aacgccagta     2040

agtgacagag tcaccaaatg ctgcacagaa tccttggtga acaggcgacc atgcttttca     2100

gctctggaag tcgatgaaac atacgttccc aaagagttta cagctaacac attcaccttc     2160

catgcagata tatgcacact ttctgagaag gagagacaaa tcaagaaaca aactgtgctt     2220

gttgagctcg tgaaacacaa gcccaaggca acaaaagagc aactgaaagc tgccatggat     2280

gatttcgcag cttttgtaga gaagtgctgc aaggctgacg ataaggagac ctgctttagc     2340

gaggagggta aaaaacttgt tgcggccagt caggccgcct taggcttatg a              2391


<210>  51
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  51

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro Asp Ala His Lys 
            180                 185                 190         


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
        195                 200                 205             


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
    210                 215                 220                 


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
225                 230                 235                 240 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
                245                 250                 255     


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
            260                 265                 270         


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
        275                 280                 285             


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
    290                 295                 300                 


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
305                 310                 315                 320 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
                325                 330                 335     


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
            340                 345                 350         


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
        355                 360                 365             


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
    370                 375                 380                 


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
385                 390                 395                 400 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
                405                 410                 415     


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
            420                 425                 430         


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
        435                 440                 445             


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
    450                 455                 460                 


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
465                 470                 475                 480 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
                485                 490                 495     


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
            500                 505                 510         


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
        515                 520                 525             


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
    530                 535                 540                 


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
545                 550                 555                 560 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
                565                 570                 575     


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
            580                 585                 590         


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Leu Ser Thr 
        595                 600                 605             


Pro Thr Leu Ile Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
    610                 615                 620                 


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
625                 630                 635                 640 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
                645                 650                 655     


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
            660                 665                 670         


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
        675                 680                 685             


Glu Phe Thr Ala Asn Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
    690                 695                 700                 


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Val Leu Val Glu Leu 
705                 710                 715                 720 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Ala Met 
                725                 730                 735     


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
            740                 745                 750         


Glu Thr Cys Phe Ser Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
        755                 760                 765             


Ala Ala Leu Gly Leu 
    770             


<210>  52
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro Gly Gly Gly Gly 
            180                 185                 190         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        195                 200                 205             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        355                 360                 365             


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Lys 
            


<210>  53
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  54
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  54

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro Gln Val Gln Leu 
            180                 185                 190         


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu 
        195                 200                 205             


Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly Asp Tyr Phe Trp 
    210                 215                 220                 


Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp Ile Gly His 
225                 230                 235                 240 


Ile His Asn Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg 
                245                 250                 255     


Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe Ser Leu Arg Leu 
            260                 265                 270         


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
        275                 280                 285             


Arg Gly Gly Asp Tyr Ala Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
    290                 295                 300                 


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
305                 310                 315                 320 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                325                 330                 335     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            340                 345                 350         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        355                 360                 365             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    370                 375                 380                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
385                 390                 395                 400 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
                405                 410                 415     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            420                 425                 430         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        435                 440                 445             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    450                 455                 460                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
465                 470                 475                 480 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                485                 490                 495     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            500                 505                 510         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        515                 520                 525             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    530                 535                 540                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
545                 550                 555                 560 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                565                 570                 575     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            580                 585                 590         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        595                 600                 605             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    610                 615                 620                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630                 635                 640 


<210>  55
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  55

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro Glu Ile Val Leu 
            180                 185                 190         


Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
        195                 200                 205             


Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Arg Ser Glu Leu Ala Trp 
    210                 215                 220                 


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu Ile Tyr Gly Ala 
225                 230                 235                 240 


Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
                245                 250                 255     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 
            260                 265                 270         


Ala Val Tyr Tyr Cys Gln Gln Phe Gly Ser Ser Pro Trp Thr Phe Gly 
        275                 280                 285             


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
    290                 295                 300                 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
305                 310                 315                 320 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
                325                 330                 335     


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
            340                 345                 350         


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
        355                 360                 365             


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
    370                 375                 380                 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
385                 390                 395                 400 


Gly Glu Cys 
            


<210>  56
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  56

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro Ala Pro Glu Leu 
            180                 185                 190         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        195                 200                 205             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    210                 215                 220                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
225                 230                 235                 240 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                245                 250                 255     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        275                 280                 285             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    290                 295                 300                 


Gln Val Thr Thr Leu Pro Pro Ser Arg Glu Glu Met Asn Lys Thr Gln 
305                 310                 315                 320 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                325                 330                 335     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr 
            340                 345                 350         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu 
        355                 360                 365             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    370                 375                 380                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
385                 390                 395                 400 


Leu Ser Pro Gly Lys 
                405 


<210>  57
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  57

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro Asp Ala His Lys 
            180                 185                 190         


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
        195                 200                 205             


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
    210                 215                 220                 


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
225                 230                 235                 240 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
                245                 250                 255     


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
            260                 265                 270         


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
        275                 280                 285             


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
    290                 295                 300                 


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
305                 310                 315                 320 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
                325                 330                 335     


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
            340                 345                 350         


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
        355                 360                 365             


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
    370                 375                 380                 


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
385                 390                 395                 400 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
                405                 410                 415     


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
            420                 425                 430         


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
        435                 440                 445             


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
    450                 455                 460                 


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
465                 470                 475                 480 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
                485                 490                 495     


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
            500                 505                 510         


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
        515                 520                 525             


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
    530                 535                 540                 


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
545                 550                 555                 560 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
                565                 570                 575     


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
            580                 585                 590         


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
        595                 600                 605             


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
    610                 615                 620                 


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
625                 630                 635                 640 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
                645                 650                 655     


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
            660                 665                 670         


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
        675                 680                 685             


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
    690                 695                 700                 


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
705                 710                 715                 720 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
                725                 730                 735     


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
            740                 745                 750         


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
        755                 760                 765             


Ala Ala Leu Gly Leu His His His His His His 
    770                 775                 


<210>  58
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  58

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro Gly Gly Gly Gly 
            180                 185                 190         


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
        195                 200                 205             


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
    210                 215                 220                 


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
225                 230                 235                 240 


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
                245                 250                 255     


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
            260                 265                 270         


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
        275                 280                 285             


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
    290                 295                 300                 


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
305                 310                 315                 320 


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
                325                 330                 335     


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
            340                 345                 350         


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
        355                 360                 365             


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
    370                 375                 380                 


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
385                 390                 395                 400 


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
                405                 410                 415     


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
            420                 425                 430         


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
        435                 440                 445             


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
    450                 455                 460                 


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
465                 470                 475                 480 


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
                485                 490                 495     


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
            500                 505                 510         


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
        515                 520                 525             


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
    530                 535                 540                 


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
545                 550                 555                 560 


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
                565                 570                 575     


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
            580                 585                 590         


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
        595                 600                 605             


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
    610                 615                 620                 


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
625                 630                 635                 640 


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
                645                 650                 655     


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
            660                 665                 670         


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
        675                 680                 685             


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
    690                 695                 700                 


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
705                 710                 715                 720 


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
                725                 730                 735     


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
            740                 745                 750         


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
        755                 760                 765             


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    770                 775         


<210>  59
<211>  718
<212>  PRT
<213>  Homo sapiens

<400>  59

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Gly Gly Gly Gly Asp Ala His 
        115                 120                 125             


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
    130                 135                 140                 


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
145                 150                 155                 160 


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
                165                 170                 175     


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
            180                 185                 190         


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
        195                 200                 205             


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
    210                 215                 220                 


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
225                 230                 235                 240 


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
                245                 250                 255     


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
            260                 265                 270         


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
        275                 280                 285             


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
    290                 295                 300                 


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
305                 310                 315                 320 


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
                325                 330                 335     


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
            340                 345                 350         


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
        355                 360                 365             


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
    370                 375                 380                 


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
385                 390                 395                 400 


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
                405                 410                 415     


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
            420                 425                 430         


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
        435                 440                 445             


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
    450                 455                 460                 


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
465                 470                 475                 480 


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
                485                 490                 495     


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
            500                 505                 510         


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
        515                 520                 525             


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
    530                 535                 540                 


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
545                 550                 555                 560 


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
                565                 570                 575     


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
            580                 585                 590         


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
        595                 600                 605             


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
    610                 615                 620                 


Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
625                 630                 635                 640 


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
                645                 650                 655     


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
            660                 665                 670         


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
        675                 680                 685             


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
    690                 695                 700                 


Gln Ala Ala Leu Gly Leu Val Asp His His His His His His 
705                 710                 715             


<210>  60
<211>  718
<212>  PRT
<213>  Homo sapiens

<400>  60

Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Gly Gly Gly Gly Asp Ala His 
        115                 120                 125             


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
    130                 135                 140                 


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
145                 150                 155                 160 


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
                165                 170                 175     


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
            180                 185                 190         


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
        195                 200                 205             


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
    210                 215                 220                 


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
225                 230                 235                 240 


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
                245                 250                 255     


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
            260                 265                 270         


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
        275                 280                 285             


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
    290                 295                 300                 


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
305                 310                 315                 320 


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
                325                 330                 335     


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
            340                 345                 350         


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
        355                 360                 365             


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
    370                 375                 380                 


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
385                 390                 395                 400 


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
                405                 410                 415     


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
            420                 425                 430         


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
        435                 440                 445             


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
    450                 455                 460                 


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
465                 470                 475                 480 


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
                485                 490                 495     


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
            500                 505                 510         


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
        515                 520                 525             


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
    530                 535                 540                 


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
545                 550                 555                 560 


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
                565                 570                 575     


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
            580                 585                 590         


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
        595                 600                 605             


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
    610                 615                 620                 


Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
625                 630                 635                 640 


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
                645                 650                 655     


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
            660                 665                 670         


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
        675                 680                 685             


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
    690                 695                 700                 


Gln Ala Ala Leu Gly Leu Val Asp His His His His His His 
705                 710                 715             


<210>  61
<211>  2391
<212>  DNA
<213>  Homo sapiens

<400>  61
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc caatgtgacg      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac cccgatgcac acaagagtga ggttgctcat      660

cgatttaaag atttgggaga agaaaatttc aaagccttgg tgttgattgc ctttgctcag      720

tatcttcagc agtgtccatt tgaagatcat gtaaaattag tgaatgaagt aactgaattt      780

gcaaaaacat gtgttgctga tgagtcagct gaaaattgtg acaaatcact tcataccctt      840

tttggagaca aattatgcac agttgcaact cttcgtgaaa cctatggtga aatggctgac      900

tgctgtgcaa aacaagaacc tgagagaaat gaatgcttct tgcaacacaa agatgacaac      960

ccaaacctcc cccgattggt gagaccagag gttgatgtga tgtgcactgc ttttcatgac     1020

aatgaagaga catttttgaa aaaatactta tatgaaattg ccagaagaca tccttacttt     1080

tatgccccgg aactcctttt ctttgctaaa aggtataaag ctgcttttac agaatgttgc     1140

caagctgctg ataaagctgc ctgcctgttg ccaaagctcg atgaacttcg ggatgaaggg     1200

aaggcttcgt ctgccaaaca gagactcaag tgtgccagtc tccaaaaatt tggagaaaga     1260

gctttcaaag catgggcagt agctcgcctg agccagagat ttcccaaagc tgagtttgca     1320

gaagtttcca agttagtgac agatcttacc aaagtccaca cggaatgctg ccatggagat     1380

ctgcttgaat gtgctgatga cagggcggac cttgccaagt atatctgtga aaatcaagat     1440

tcgatctcca gtaaactgaa ggaatgctgt gaaaaacctc tgttggaaaa atcccactgc     1500

attgccgaag tggaaaatga tgagatgcct gctgacttgc cttcattagc tgctgatttt     1560

gttgaaagta aggatgtttg caaaaactat gctgaggcaa aggatgtctt cctgggcatg     1620

tttttgtatg aatatgcaag aaggcatcct gattactctg tcgtgctgct gctgagactt     1680

gccaagacat atgaaaccac tctagagaag tgctgtgccg ctgcagatcc tcatgaatgc     1740

tatgccaaag tgttcgatga atttaaacct cttgtggaag agcctcagaa tttaatcaaa     1800

caaaattgtg agctttttga gcagcttgga gagtacaaat tccagaatgc gctattagtt     1860

cgttacacca agaaagtacc ccaactgtca actccaactc ttatcgaggt ctcaagaaac     1920

ctaggaaaag tgggcagcaa atgttgtaaa catcctgaag caaaaagaat gccctgtgca     1980

gaagactatc tatccgtggt cctgaaccag ttatgtgtgt tgcatgagaa aacgccagta     2040

agtgacagag tcaccaaatg ctgcacagaa tccttggtga acaggcgacc atgcttttca     2100

gctctggaag tcgatgaaac atacgttccc aaagagttta cagctaacac attcaccttc     2160

catgcagata tatgcacact ttctgagaag gagagacaaa tcaagaaaca aactgtgctt     2220

gttgagctcg tgaaacacaa gcccaaggca acaaaagagc aactgaaagc tgccatggat     2280

gatttcgcag cttttgtaga gaagtgctgc aaggctgacg ataaggagac ctgctttagc     2340

gaggagggta aaaaacttgt tgcggccagt caggccgcct taggcttatg a              2391


<210>  62
<211>  1326
<212>  DNA
<213>  Homo sapiens

<400>  62
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccagtgtggt ggggaagaag ctggtaaagg aggggcccaa tggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccata cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac cccggtggag gtggagacaa aactcacaca      660

tgtcccccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg agaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatcccgg aaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctga agtccgacgg ctccttcttc     1200

ctctatagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaa                                                                1326


<210>  63
<211>  741
<212>  DNA
<213>  Homo sapiens

<400>  63
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt ctgcgctgac       60

aaaactcaca catgtccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      120

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      180

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      240

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      300

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      360

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      420

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      480

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg      540

gagagcaatg ggcagccgga gaacaactac gacaccacgc ctcccgtgct ggactccgac      600

ggctccttct tcctctatag cgacctcacc gtggacaaga gcaggtggca gcaggggaac      660

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      720

tccctgtctc cgggtaaatg a                                                741


<210>  64
<211>  1989
<212>  DNA
<213>  Homo sapiens

<400>  64
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaat ctgacaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggcccct      600

ccggataaaa gcatcatcaa tgccacagac ccccaggtgc agctgcagga gtcgggccca      660

ggactggtga agccttcaca gaccctgtcc ctcacctgca ctgtctctgg tggctccatc      720

agcagtggtg attacttctg gagctggatc cgccagctcc cagggaaggg cctggagtgg      780

attgggcaca tccataacag tgggaccacc tactacaatc cgtccctcaa gagtcgagtt      840

accatatcag tagacacgtc taagaagcag ttctccctga ggctgagttc tgtgactgcc      900

gcggacacgg ccgtatatta ctgtgcgaga gatcgagggg gtgactacgc ttatggtatg      960

gacgtctggg gccaagggac cacggtcacc gtctcctcag cctccaccaa gggcccatcc     1020

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     1080

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     1140

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     1200

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     1260

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac     1320

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     1380

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     1440

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1500

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1560

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1620

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1680

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1740

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1800

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1860

ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1920

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1980

ccgggtaaa                                                             1989


<210>  65
<211>  1278
<212>  DNA
<213>  Homo sapiens

<400>  65
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaat ctgacaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcactt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggcccct      600

ccggataaaa gcatcatcaa tgccacagac cccgaaattg tgttgacgca gtctccaggc      660

accctgtctt tgtctccagg ggaaagagcc accctctcct gcagggccag tcagggtatt      720

agtagaagcg aattagcctg gtaccagcag aaacctggcc aggctcccag cctcctcatc      780

tatggtgcat ccagcagggc cactggcatc ccagacaggt tcagtggcag tgggtctggg      840

acagacttca ctctcaccat cagcagactg gagcctgaag attttgcagt gtattactgt      900

caacaatttg gtagttcacc gtggacgttc ggccaaggga ccaaggtgga aatcaaacga      960

actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     1020

actgctagcg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg     1080

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc     1140

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa     1200

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc     1260

ttcaacaggg gagagtgt                                                   1278


<210>  66
<211>  1284
<212>  DNA
<213>  Homo sapiens

<400>  66
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc caatgtgacg      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta atctgacggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctataat ggcacgatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tacgtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac cccgcacctg aactcctggg gggaccgtca      660

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      720

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      780

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      840

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      900

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      960

aaagggcagc cccgagaacc acaggtgacc accctgcccc catcccggga ggagatgaac     1020

aagacccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1080

gagtgggaga gcaatgggca gccggagaac aactacgaca ccacgcctcc cgtgctggac     1140

tccgacggct ccttcttcct ctatagcgac ctcaccgtgg acaagagcag gtggcagcag     1200

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1260

agcctctccc tgtctccggg taag                                            1284


<210>  67
<211>  2409
<212>  DNA
<213>  Homo sapiens

<400>  67
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccata cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac cccgatgcac acaagagtga ggttgctcat      660

cggtttaaag atttgggaga agaaaatttc aaagccttgg tgttgattgc ctttgctcag      720

tatcttcagc agtgtccatt tgaagatcat gtaaaattag tgaatgaagt aactgaattt      780

gcaaaaacat gtgttgctga tgagtcagct gaaaattgtg acaaatcact tcataccctt      840

tttggagaca aattatgcac agttgcaact cttcgtgaaa cctatggtga aatggctgac      900

tgctgtgcaa aacaagaacc tgagagaaat gaatgcttct tgcaacacaa agatgacaac      960

ccaaacctcc cccgattggt gagaccagag gttgatgtga tgtgcactgc ttttcatgac     1020

aatgaagaga catttttgaa aaaatactta tatgaaattg ccagaagaca tccttacttt     1080

tatgccccgg aactcctttt ctttgctaaa aggtataaag ctgcttttac agaatgttgc     1140

caagctgctg ataaagctgc ctgcctgttg ccaaagctcg atgaacttcg ggatgaaggg     1200

aaggcttcgt ctgccaaaca gagactcaag tgtgccagtc tccaaaaatt tggagaaaga     1260

gctttcaaag catgggcagt agctcgcctg agccagagat ttcccaaagc tgagtttgca     1320

gaagtttcca agttagtgac agatcttacc aaagtccaca cggaatgctg ccatggagat     1380

ctgcttgaat gtgctgatga cagggcggac cttgccaagt atatctgtga aaatcaagat     1440

tcgatctcca gtaaactgaa ggaatgctgt gaaaaacctc tgttggaaaa atcccactgc     1500

attgccgaag tggaaaatga tgagatgcct gctgacttgc cttcattagc tgctgatttt     1560

gttgaaagta aggatgtttg caaaaactat gctgaggcaa aggatgtctt cctgggcatg     1620

tttttgtatg aatatgcaag aaggcatcct gattactctg tcgtgctgct gctgagactt     1680

gccaagacat atgaaaccac tctagagaag tgctgtgccg ctgcagatcc tcatgaatgc     1740

tatgccaaag tgttcgatga atttaaacct cttgtggaag agcctcagaa tttaatcaaa     1800

caaaattgtg agctttttga gcagcttgga gagtacaaat tccagaatgc gctattagtt     1860

cgttacacca agaaagtacc ccaagtgtca actccaactc ttgtagaggt ctcaagaaac     1920

ctaggaaaag tgggcagcaa atgttgtaaa catcctgaag caaaaagaat gccctgtgca     1980

gaagactatc tatccgtggt cctgaaccag ttatgtgtgt tgcatgagaa aacgccagta     2040

agtgacagag tcaccaaatg ctgcacagaa tccttggtga acaggcgacc atgcttttca     2100

gctctggaag tcgatgaaac atacgttccc aaagagttta atgctgaaac attcaccttc     2160

catgcagata tatgcacact ttctgagaag gagagacaaa tcaagaaaca aactgcactt     2220

gttgagctcg tgaaacacaa gcccaaggca acaaaagagc aactgaaagc tgttatggat     2280

gatttcgcag cttttgtaga gaagtgctgc aaggctgacg ataaggagac ctgctttgcc     2340

gaggagggta aaaaacttgt tgctgcaagt caagctgcct taggcttaca tcatcatcat     2400

catcattga                                                             2409


<210>  68
<211>  2400
<212>  DNA
<213>  Homo sapiens

<400>  68
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccagtgtggt ggggaagaag ctggtaaagg aggggcccaa tggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccata cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac cccggtggag gtggagatgc acacaagagt      660

gaggttgctc atcggtttaa agatttggga gaagaaaatt tcaaagcctt ggtgttgatt      720

gcctttgctc agtatcttca gcagtgtcca tttgaagatc atgtaaaatt agtgaatgaa      780

gtaactgaat ttgcaaaaac atgtgttgct gatgagtcag ctgaaaattg tgacaaatca      840

cttcataccc tttttggaga caaattatgc acagttgcaa ctcttcgtga aacctatggt      900

gaaatggctg actgctgtgc aaaacaagaa cctgagagaa atgaatgctt cttgcaacac      960

aaagatgaca acccaaacct cccccgattg gtgagaccag aggttgatgt gatgtgcact     1020

gcttttcatg acaatgaaga gacatttttg aaaaaatact tatatgaaat tgccagaaga     1080

catccttact tttatgcccc ggaactcctt ttctttgcta aaaggtataa agctgctttt     1140

acagaatgtt gccaagctgc tgataaagct gcctgcctgt tgccaaagct cgatgaactt     1200

cgggatgaag ggaaggcttc gtctgccaaa cagagactca agtgtgccag tctccaaaaa     1260

tttggagaaa gagctttcaa agcatgggca gtagctcgcc tgagccagag atttcccaaa     1320

gctgagtttg cagaagtttc caagttagtg acagatctta ccaaagtcca cacggaatgc     1380

tgccatggag atctgcttga atgtgctgat gacagggcgg accttgccaa gtatatctgt     1440

gaaaatcaag attcgatctc cagtaaactg aaggaatgct gtgaaaaacc tctgttggaa     1500

aaatcccact gcattgccga agtggaaaat gatgagatgc ctgctgactt gccttcatta     1560

gctgctgatt ttgttgaaag taaggatgtt tgcaaaaact atgctgaggc aaaggatgtc     1620

ttcctgggca tgtttttgta tgaatatgca agaaggcatc ctgattactc tgtcgtgctg     1680

ctgctgagac ttgccaagac atatgaaacc actctagaga agtgctgtgc cgctgcagat     1740

cctcatgaat gctatgccaa agtgttcgat gaatttaaac ctcttgtgga agagcctcag     1800

aatttaatca aacaaaattg tgagcttttt gagcagcttg gagagtacaa attccagaat     1860

gcgctattag ttcgttacac caagaaagta ccccaagtgt caactccaac tcttgtagag     1920

gtctcaagaa acctaggaaa agtgggcagc aaatgttgta aacatcctga agcaaaaaga     1980

atgccctgtg cagaagacta tctatccgtg gtcctgaacc agttatgtgt gttgcatgag     2040

aaaacgccag taagtgacag agtcaccaaa tgctgcacag aatccttggt gaacaggcga     2100

ccatgctttt cagctctgga agtcgatgaa acatacgttc ccaaagagtt taatgctgaa     2160

acattcacct tccatgcaga tatatgcaca ctttctgaga aggagagaca aatcaagaaa     2220

caaactgcac ttgttgagct cgtgaaacac aagcccaagg caacaaaaga gcaactgaaa     2280

gctgttatgg atgatttcgc agcttttgta gagaagtgct gcaaggctga cgataaggag     2340

acctgctttg ccgaggaggg taaaaaactt gttgctgcaa gtcaagctgc cttaggctta     2400


<210>  69
<211>  2223
<212>  DNA
<213>  Homo sapiens

<400>  69
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta acggtggagg tggagatgca cacaagagtg aggttgctca tcgatttaaa      480

gatttgggag aagaaaattt caaagccttg gtgttgattg cctttgctca gtatcttcag      540

cagtgtccat ttgaagatca tgtaaaatta gtgaatgaag taactgaatt tgcaaaaaca      600

tgtgttgctg atgagtcagc tgaaaattgt gacaaatcac ttcataccct ttttggagac      660

aaattatgca cagttgcaac tcttcgtgaa acctatggtg aaatggctga ctgctgtgca      720

aaacaagaac ctgagagaaa tgaatgcttc ttgcaacaca aagatgacaa cccaaacctc      780

ccccgattgg tgagaccaga ggttgatgtg atgtgcactg cttttcatga caatgaagag      840

acatttttga aaaaatactt atatgaaatt gccagaagac atccttactt ttatgccccg      900

gaactccttt tctttgctaa aaggtataaa gctgctttta cagaatgttg ccaagctgct      960

gataaagctg cctgcctgtt gccaaagctc gatgaacttc gggatgaagg gaaggcttcg     1020

tctgccaaac agagactcaa gtgtgccagt ctccaaaaat ttggagaaag agctttcaaa     1080

gcatgggcag tagctcgcct gagccagaga tttcccaaag ctgagtttgc agaagtttcc     1140

aagttagtga cagatcttac caaagtccac acggaatgct gccatggaga tctgcttgaa     1200

tgtgctgatg acagggcgga ccttgccaag tatatctgtg aaaatcaaga ttcgatctcc     1260

agtaaactga aggaatgctg tgaaaaacct ctgttggaaa aatcccactg cattgccgaa     1320

gtggaaaatg atgagatgcc tgctgacttg ccttcattag ctgctgattt tgttgaaagt     1380

aaggatgttt gcaaaaacta tgctgaggca aaggatgtct tcctgggcat gtttttgtat     1440

gaatatgcaa gaaggcatcc tgattactct gtcgtgctgc tgctgagact tgccaagaca     1500

tatgaaacca ctctagagaa gtgctgtgcc gctgcagatc ctcatgaatg ctatgccaaa     1560

gtgttcgatg aatttaaacc tcttgtggaa gagcctcaga atttaatcaa acaaaattgt     1620

gagctttttg agcagcttgg agagtacaaa ttccagaatg cgctattagt tcgttacacc     1680

aagaaagtac cccaagtgtc aactccaact cttgtagagg tctcaagaaa cctaggaaaa     1740

gtgggcagca aatgttgtaa acatcctgaa gcaaaaagaa tgccctgtgc agaagactat     1800

ctatccgtgg tcctgaacca gttatgtgtg ttgcatgaga aaacgccagt aagtgacaga     1860

gtcaccaaat gctgcacaga atccttggtg aacaggcgac catgcttttc agctctggaa     1920

gtcgatgaaa catacgttcc caaagagttt aatgctgaaa cattcacctt ccatgcagat     1980

atatgcacac tttctgagaa ggagagacaa atcaagaaac aaactgcact tgttgagctc     2040

gtgaaacaca agcccaaggc aacaaaagag caactgaaag ctgttatgga tgatttcgca     2100

gcttttgtag agaagtgctg caaggctgac gataaggaga cctgctttgc cgaggagggt     2160

aaaaaacttg ttgcggccag tcaggccgcc ttaggcttag tcgaccatca tcatcatcat     2220

cat                                                                   2223


<210>  70
<211>  2223
<212>  DNA
<213>  Homo sapiens

<400>  70
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccagtgtggt ggggaagaag ctggtaaagg aggggcccaa tggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccata cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta acggtggagg tggagatgca cacaagagtg aggttgctca tcgatttaaa      480

gatttgggag aagaaaattt caaagccttg gtgttgattg cctttgctca gtatcttcag      540

cagtgtccat ttgaagatca tgtaaaatta gtgaatgaag taactgaatt tgcaaaaaca      600

tgtgttgctg atgagtcagc tgaaaattgt gacaaatcac ttcataccct ttttggagac      660

aaattatgca cagttgcaac tcttcgtgaa acctatggtg aaatggctga ctgctgtgca      720

aaacaagaac ctgagagaaa tgaatgcttc ttgcaacaca aagatgacaa cccaaacctc      780

ccccgattgg tgagaccaga ggttgatgtg atgtgcactg cttttcatga caatgaagag      840

acatttttga aaaaatactt atatgaaatt gccagaagac atccttactt ttatgccccg      900

gaactccttt tctttgctaa aaggtataaa gctgctttta cagaatgttg ccaagctgct      960

gataaagctg cctgcctgtt gccaaagctc gatgaacttc gggatgaagg gaaggcttcg     1020

tctgccaaac agagactcaa gtgtgccagt ctccaaaaat ttggagaaag agctttcaaa     1080

gcatgggcag tagctcgcct gagccagaga tttcccaaag ctgagtttgc agaagtttcc     1140

aagttagtga cagatcttac caaagtccac acggaatgct gccatggaga tctgcttgaa     1200

tgtgctgatg acagggcgga ccttgccaag tatatctgtg aaaatcaaga ttcgatctcc     1260

agtaaactga aggaatgctg tgaaaaacct ctgttggaaa aatcccactg cattgccgaa     1320

gtggaaaatg atgagatgcc tgctgacttg ccttcattag ctgctgattt tgttgaaagt     1380

aaggatgttt gcaaaaacta tgctgaggca aaggatgtct tcctgggcat gtttttgtat     1440

gaatatgcaa gaaggcatcc tgattactct gtcgtgctgc tgctgagact tgccaagaca     1500

tatgaaacca ctctagagaa gtgctgtgcc gctgcagatc ctcatgaatg ctatgccaaa     1560

gtgttcgatg aatttaaacc tcttgtggaa gagcctcaga atttaatcaa acaaaattgt     1620

gagctttttg agcagcttgg agagtacaaa ttccagaatg cgctattagt tcgttacacc     1680

aagaaagtac cccaagtgtc aactccaact cttgtagagg tctcaagaaa cctaggaaaa     1740

gtgggcagca aatgttgtaa acatcctgaa gcaaaaagaa tgccctgtgc agaagactat     1800

ctatccgtgg tcctgaacca gttatgtgtg ttgcatgaga aaacgccagt aagtgacaga     1860

gtcaccaaat gctgcacaga atccttggtg aacaggcgac catgcttttc agctctggaa     1920

gtcgatgaaa catacgttcc caaagagttt aatgctgaaa cattcacctt ccatgcagat     1980

atatgcacac tttctgagaa ggagagacaa atcaagaaac aaactgcact tgttgagctc     2040

gtgaaacaca agcccaaggc aacaaaagag caactgaaag ctgttatgga tgatttcgca     2100

gcttttgtag agaagtgctg caaggctgac gataaggaga cctgctttgc cgaggagggt     2160

aaaaaacttg ttgcggccag tcaggccgcc ttaggcttag tcgaccatca tcatcatcat     2220

cat                                                                   2223


<210>  71
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  72
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  72

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  73
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  73

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Thr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Asn Lys Thr Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  74
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  74

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Thr Thr Leu Pro Pro Ser Arg Glu Glu Met Asn Lys Thr Gln Val 
        115                 120                 125             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    130                 135                 140                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro 
145                 150                 155                 160 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr 
                165                 170                 175     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            180                 185                 190         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        195                 200                 205             


Ser Pro Gly Lys 
    210         


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  75

Glu Pro Lys Ser Ser 
1               5   
