               SEQUENCE LISTING

<110> Heptares Therapeutics Limited

<120> Glucagon StaR

<150> GB1415094.0
<151> 2014-08-26

<160> 1

<170> BiSSAP 1.2

<210> 1
<211> 477
<212> PRT
<213> Homo sapiens

<220> 
<223> Glucagon receptor

<400> 1
Met Pro Pro Cys Gln Pro Gln Arg Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      
Leu Ala Cys Gln Pro Gln Val Pro Ser Ala Gln Val Met Asp Phe Leu 
            20                  25                  30          
Phe Glu Lys Trp Lys Leu Tyr Gly Asp Gln Cys His His Asn Leu Ser 
        35                  40                  45              
Leu Leu Pro Pro Pro Thr Glu Leu Val Cys Asn Arg Thr Phe Asp Lys 
    50                  55                  60                  
Tyr Ser Cys Trp Pro Asp Thr Pro Ala Asn Thr Thr Ala Asn Ile Ser 
65                  70                  75                  80  
Cys Pro Trp Tyr Leu Pro Trp His His Lys Val Gln His Arg Phe Val 
                85                  90                  95      
Phe Lys Arg Cys Gly Pro Asp Gly Gln Trp Val Arg Gly Pro Arg Gly 
            100                 105                 110         
Gln Pro Trp Arg Asp Ala Ser Gln Cys Gln Met Asp Gly Glu Glu Ile 
        115                 120                 125             
Glu Val Gln Lys Glu Val Ala Lys Met Tyr Ser Ser Phe Gln Val Met 
    130                 135                 140                 
Tyr Thr Val Gly Tyr Ser Leu Ser Leu Gly Ala Leu Leu Leu Ala Leu 
145                 150                 155                 160 
Ala Ile Leu Gly Gly Leu Ser Lys Leu His Cys Thr Arg Asn Ala Ile 
                165                 170                 175     
His Ala Asn Leu Phe Ala Ser Phe Val Leu Lys Ala Ser Ser Val Leu 
            180                 185                 190         
Val Ile Asp Gly Leu Leu Arg Thr Arg Tyr Ser Gln Lys Ile Gly Asp 
        195                 200                 205             
Asp Leu Ser Val Ser Thr Trp Leu Ser Asp Gly Ala Val Ala Gly Cys 
    210                 215                 220                 
Arg Val Ala Ala Val Phe Met Gln Tyr Gly Ile Val Ala Asn Tyr Cys 
225                 230                 235                 240 
Trp Leu Leu Val Glu Gly Leu Tyr Leu His Asn Leu Leu Gly Leu Ala 
                245                 250                 255     
Thr Leu Pro Glu Arg Ser Phe Phe Ser Leu Tyr Leu Gly Ile Gly Trp 
            260                 265                 270         
Gly Ala Pro Met Leu Phe Val Val Pro Trp Ala Val Val Lys Cys Leu 
        275                 280                 285             
Phe Glu Asn Val Gln Cys Trp Thr Ser Asn Asp Asn Met Gly Phe Trp 
    290                 295                 300                 
Trp Ile Leu Arg Phe Pro Val Phe Leu Ala Ile Leu Ile Asn Phe Phe 
305                 310                 315                 320 
Ile Phe Val Arg Ile Val Gln Leu Leu Val Ala Lys Leu Arg Ala Arg 
                325                 330                 335     
Gln Met His His Thr Asp Tyr Lys Phe Arg Leu Ala Lys Ser Thr Leu 
            340                 345                 350         
Thr Leu Ile Pro Leu Leu Gly Val His Glu Val Val Phe Ala Phe Val 
        355                 360                 365             
Thr Asp Glu His Ala Gln Gly Thr Leu Arg Ser Ala Lys Leu Phe Phe 
    370                 375                 380                 
Asp Leu Phe Leu Ser Ser Phe Gln Gly Leu Leu Val Ala Val Leu Tyr 
385                 390                 395                 400 
Cys Phe Leu Asn Lys Glu Val Gln Ser Glu Leu Arg Arg Arg Trp His 
                405                 410                 415     
Arg Trp Arg Leu Gly Lys Val Leu Trp Glu Glu Arg Asn Thr Ser Asn 
            420                 425                 430         
His Arg Ala Ser Ser Ser Pro Gly His Gly Pro Pro Ser Lys Glu Leu 
        435                 440                 445             
Gln Phe Gly Arg Gly Gly Gly Ser Gln Asp Ser Ser Ala Glu Thr Pro 
    450                 455                 460                 
Leu Ala Gly Gly Leu Pro Arg Leu Ala Glu Ser Pro Phe 
465                 470                 475         

