               SEQUENCE LISTING

<110> Andersson, Roland
      Ansari, Daniel
      Marko-Varga, Gyorgy

<120> METHOD FOR DETERMINING A SUBJECT’S PROBABILITY TO SUFFER FROM PANCREATIC CANCER

<130> W134200001

<150> SE1450991-3
<151> 2014-08-26

<160> 148

<170> BiSSAP 1.3

<210> 1
<211> 10
<212> PRT
<213> human

<400> 1
Leu Leu Val Val Tyr Pro Trp Thr Gln Arg 
1               5                   10  

<210> 2
<211> 17
<212> PRT
<213> human

<400> 2
Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro Glu Asn Phe 
1               5                   10                  15      
Lys 
    

<210> 3
<211> 6
<212> PRT
<213> human

<400> 3
Asp Ile Cys Ala Thr Lys 
1               5       

<210> 4
<211> 4
<212> PRT
<213> human

<400> 4
Asp Leu Leu Lys 
1               

<210> 5
<211> 6
<212> PRT
<213> human

<400> 5
Glu Val Ser Val Met Arg 
1               5       

<210> 6
<211> 15
<212> PRT
<213> human

<400> 6
Lys Gly Ser Ile His Val Ser Ser Ala Ile Thr Glu Asp Gln Lys 
1               5                   10                  15  

<210> 7
<211> 4
<212> PRT
<213> human

<400> 7
Leu Ser Glu Lys 
1               

<210> 8
<211> 16
<212> PRT
<213> human

<400> 8
Asn Val Thr Leu Asp Val Gln Ile Gln His Val Val Glu Gly Lys Arg 
1               5                   10                  15      



<210> 9
<211> 14
<212> PRT
<213> human

<400> 9
Ser Ser Gln Asp Val Ser Leu Asp Ser Asn Ser Asn Ser Lys 
1               5                   10                  

<210> 10
<211> 28
<212> PRT
<213> human

<400> 10
Val Glu Thr Glu Glu Thr His Asn Tyr Val Gly Phe Glu Asp Ile Ile 
1               5                   10                  15      
Asp Ser Leu Gln Asp Asn Val Ala Asp Ile Lys Lys 
            20                  25              

<210> 11
<211> 4
<212> PRT
<213> human

<400> 11
Leu Glu Glu Arg 
1               

<210> 12
<211> 17
<212> PRT
<213> human

<400> 12
Gln Asp Ala Asp Pro Gly Glu Val Pro Gly Gly Ser Lys Glu Ser Ala 
1               5                   10                  15      
Arg 
    

<210> 13
<211> 11
<212> PRT
<213> human

<400> 13
Ser Asn Ser Leu Pro Phe Val Glu Gly Ser Arg 
1               5                   10      

<210> 14
<211> 7
<212> PRT
<213> human

<400> 14
Thr Pro Thr Trp Val Arg Arg 
1               5           

<210> 15
<211> 5
<212> PRT
<213> human

<400> 15
Leu Gln His Leu Lys 
1               5   

<210> 16
<211> 5
<212> PRT
<213> human

<400> 16
Gln Leu Thr Glu Lys 
1               5   

<210> 17
<211> 35
<212> PRT
<213> human

<400> 17
Thr Glu Ala Val Arg Glu Asp Leu Val Pro Ser Glu Ser Asn Ala Phe 
1               5                   10                  15      
Leu Pro Ser Ser Val Leu Trp Leu Ser Pro Ser Thr Ala Leu Ala Ala 
            20                  25                  30          
Asp Phe Arg 
        35  

<210> 18
<211> 22
<212> PRT
<213> human

<400> 18
Val Asn His Val Asp Pro Glu Glu Glu Ile Val Glu His Gly Ala Met 
1               5                   10                  15      
Glu Glu Arg Glu Met Arg 
            20          

<210> 19
<211> 6
<212> PRT
<213> human

<400> 19
Glu Glu Cys Ala Ala Lys 
1               5       

<210> 20
<211> 11
<212> PRT
<213> human

<400> 20
Glu Glu Cys Ala Ala Lys Cys Glu Glu Asp Lys 
1               5                   10      

<210> 21
<211> 11
<212> PRT
<213> human

<400> 21
Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
1               5                   10      

<210> 22
<211> 12
<212> PRT
<213> human

<400> 22
Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg Lys 
1               5                   10          

<210> 23
<211> 8
<212> PRT
<213> human

<400> 23
Lys Gln Leu Gly Ala Gly Ser Arg 
1               5               

<210> 24
<211> 9
<212> PRT
<213> human

<400> 24
Met Arg Asp Ala Val Leu Phe Glu Lys 
1               5                   

<210> 25
<211> 24
<212> PRT
<213> human

<400> 25
Ser Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Pro 
1               5                   10                  15      
Ser Leu Phe Ser Val Thr Lys Lys 
            20                  

<210> 26
<211> 6
<212> PRT
<213> human

<400> 26
Ser Ser Ile Ile Ile Arg 
1               5       

<210> 27
<211> 8
<212> PRT
<213> human

<400> 27
Asp Ser Lys Phe Leu Leu Pro Lys 
1               5               

<210> 28
<211> 4
<212> PRT
<213> human

<400> 28
Leu Glu Glu Lys 
1               

<210> 29
<211> 6
<212> PRT
<213> human

<400> 29
Asp Val Asp Asn Leu Lys 
1               5       

<210> 30
<211> 32
<212> PRT
<213> human

<400> 30
Ala Leu Phe Arg Asn Leu Ser Ser Leu Glu Ser Val Gln Leu Asp His 
1               5                   10                  15      
Asn Gln Leu Glu Thr Leu Pro Gly Asp Val Phe Gly Ala Leu Pro Arg 
            20                  25                  30          



<210> 31
<211> 11
<212> PRT
<213> human

<400> 31
Ala Gln Pro Phe Pro Cys Pro Pro Ala Cys Lys 
1               5                   10      

<210> 32
<211> 15
<212> PRT
<213> human

<400> 32
Met Val Leu Leu Glu Gln Leu Phe Leu Asp His Asn Ala Leu Arg 
1               5                   10                  15  

<210> 33
<211> 9
<212> PRT
<213> human

<400> 33
Ala Val Leu His Gly Asn Leu Glu Lys 
1               5                   

<210> 34
<211> 28
<212> PRT
<213> human

<400> 34
Ala Val Gln Leu Arg Gln Glu Ala Cys Ala Thr Leu Leu Leu Gln Asn 
1               5                   10                  15      
Gly Ala Asn Pro Asn Ile Thr Asp Phe Phe Gly Arg 
            20                  25              

<210> 35
<211> 13
<212> PRT
<213> human

<400> 35
Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys Ser Lys 
1               5                   10              

<210> 36
<211> 9
<212> PRT
<213> human

<400> 36
Arg Cys Glu Leu Asn Leu Cys Asp Arg 
1               5                   

<210> 37
<211> 21
<212> PRT
<213> human

<400> 37
Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met Val His 
1               5                   10                  15      
Leu Leu Val Ser Arg 
            20      

<210> 38
<211> 5
<212> PRT
<213> human

<400> 38
Thr Pro Leu Ile Lys 
1               5   

<210> 39
<211> 7
<212> PRT
<213> human

<400> 39
Trp Pro Thr Leu Met Glu Arg 
1               5           

<210> 40
<211> 11
<212> PRT
<213> human

<400> 40
Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys 
1               5                   10      

<210> 41
<211> 4
<212> PRT
<213> human

<400> 41
Glu Asp Leu Lys 
1               

<210> 42
<211> 6
<212> PRT
<213> human

<400> 42
Glu Glu Phe Tyr Ser Arg 
1               5       

<210> 43
<211> 12
<212> PRT
<213> human

<400> 43
Phe Met Pro Met Asp Asn Leu Ser Gly Gly Glu Lys 
1               5                   10          

<210> 44
<211> 16
<212> PRT
<213> human

<400> 44
Lys Ala Glu Glu Asn Cys Leu Gln Thr Val Asn Glu Leu Met Ala Lys 
1               5                   10                  15      



<210> 45
<211> 12
<212> PRT
<213> human

<400> 45
Leu Lys Tyr Ser Gln Asn Glu Leu Glu Met Ile Lys 
1               5                   10          

<210> 46
<211> 12
<212> PRT
<213> human

<400> 46
Arg Asp Ile Glu Leu Glu Ala Ser Gln Leu Asp Arg 
1               5                   10          

<210> 47
<211> 13
<212> PRT
<213> human

<400> 47
Arg Phe Met Pro Met Asp Asn Leu Ser Gly Gly Glu Lys 
1               5                   10              

<210> 48
<211> 12
<212> PRT
<213> human

<400> 48
Ser Gly Val Ile Ser Gly Gly Ser Ser Asp Leu Lys 
1               5                   10          

<210> 49
<211> 9
<212> PRT
<213> human

<400> 49
Ser Val Glu Thr Leu Leu Asn Gln Lys 
1               5                   

<210> 50
<211> 13
<212> PRT
<213> human

<400> 50
Cys Gln Ile Val Asn Val Ala Ala Glu Ile Phe Leu Lys 
1               5                   10              

<210> 51
<211> 27
<212> PRT
<213> human

<400> 51
Asp Val Asn Thr Ser Leu Gly Glu Val Ala Asn Glu Thr Ser Glu Asn 
1               5                   10                  15      
Glu Thr Leu Gly Asp Phe Ser Glu Gln Ile Lys 
            20                  25          

<210> 52
<211> 4
<212> PRT
<213> human

<400> 52
Glu Asp Leu Arg 
1               

<210> 53
<211> 18
<212> PRT
<213> human

<400> 53
Glu Glu Thr Glu Asn Ala Ser Glu Pro Leu Gly Tyr Glu Ser Met Ala 
1               5                   10                  15      
Ser Lys 
        

<210> 54
<211> 11
<212> PRT
<213> human

<400> 54
Ile Gly Ile Ser Ala Met Tyr Phe Tyr His Lys 
1               5                   10      

<210> 55
<211> 16
<212> PRT
<213> human

<400> 55
Lys Ala Cys Ile Ala Gln Gln Thr Phe Ile Val Pro Asp Leu Val Lys 
1               5                   10                  15      



<210> 56
<211> 22
<212> PRT
<213> human

<400> 56
Leu Asp Ser Asn Ser Asn Cys Leu Ser Ser Val Ser Ala Val Glu Pro 
1               5                   10                  15      
Thr Leu Met Val Ile Lys 
            20          

<210> 57
<211> 4
<212> PRT
<213> human

<400> 57
Leu Gln Met Arg 
1               

<210> 58
<211> 4
<212> PRT
<213> human

<400> 58
Leu Ser Glu Lys 
1               

<210> 59
<211> 4
<212> PRT
<213> human

<400> 59
Leu Trp Leu Lys 
1               

<210> 60
<211> 12
<212> PRT
<213> human

<400> 60
Gln Glu Ile Thr Ala Val Leu Glu Met Lys Ser Arg 
1               5                   10          

<210> 61
<211> 20
<212> PRT
<213> human

<400> 61
Ser Glu Leu Met Leu Gln Glu Asn Gln Met Ile Ala Asp Gly Lys Glu 
1               5                   10                  15      
Ala Glu Thr Lys 
            20  

<210> 62
<211> 5
<212> PRT
<213> human

<400> 62
Ser Leu Ala Glu Lys 
1               5   

<210> 63
<211> 11
<212> PRT
<213> human

<400> 63
Ser Asn Asp Asp Tyr Gln Ala Ala Val Glu Arg 
1               5                   10      

<210> 64
<211> 22
<212> PRT
<213> human

<400> 64
Ser Ser Glu Arg Glu Ala Tyr Ser Pro Leu Glu Leu Leu Asp Asn Leu 
1               5                   10                  15      
Ser Gly Ala Asp Val Arg 
            20          

<210> 65
<211> 9
<212> PRT
<213> human

<400> 65
Thr Trp Pro Tyr Tyr Ser Cys Ala Arg 
1               5                   

<210> 66
<211> 16
<212> PRT
<213> human

<400> 66
Thr Trp Pro Tyr Tyr Ser Cys Ala Arg Ile Ser Ala Trp Cys Trp Lys 
1               5                   10                  15      



<210> 67
<211> 16
<212> PRT
<213> human

<400> 67
Thr Trp Pro Tyr Tyr Ser Cys Ala Arg Ile Ser Ala Trp Cys Trp Lys 
1               5                   10                  15      



<210> 68
<211> 10
<212> PRT
<213> human

<400> 68
Tyr Cys Lys Phe His Phe Asn Thr Leu Arg 
1               5                   10  

<210> 69
<211> 4
<212> PRT
<213> human

<400> 69
Asp Glu Leu Arg 
1               

<210> 70
<211> 15
<212> PRT
<213> human

<400> 70
Glu Glu Asp Glu Glu Gly Glu Asp Val Val Thr Ser Thr Gly Arg 
1               5                   10                  15  

<210> 71
<211> 9
<212> PRT
<213> human

<400> 71
Gly Ser Leu Ser Gln Glu Met Ala Lys 
1               5                   

<210> 72
<211> 12
<212> PRT
<213> human

<400> 72
His Ala Tyr Val His Lys Pro Tyr Leu Tyr Ser Lys 
1               5                   10          

<210> 73
<211> 15
<212> PRT
<213> human

<400> 73
Lys Glu Thr Glu Gly Thr Val Thr Cys Thr Gly Ala Glu Gly Arg 
1               5                   10                  15  

<210> 74
<211> 4
<212> PRT
<213> human

<400> 74
Leu Glu Glu Lys 
1               

<210> 75
<211> 12
<212> PRT
<213> human

<400> 75
Leu Ser Glu Ser Leu His Val Val Asp Glu Asn Lys 
1               5                   10          

<210> 76
<211> 4
<212> PRT
<213> human

<400> 76
Leu Val Leu Lys 
1               

<210> 77
<211> 15
<212> PRT
<213> human

<400> 77
Thr Gly Asp Glu Thr Glu Leu His Ser Ser Glu Lys Gly Leu Lys 
1               5                   10                  15  

<210> 78
<211> 26
<212> PRT
<213> human

<400> 78
Val Glu Asp Leu Ser Asp Ala Ala Ile Ile Ser Thr Ser Thr Ala Glu 
1               5                   10                  15      
Cys Met Pro Ile Ser Ala Ser Ile Asp Arg 
            20                  25      

<210> 79
<211> 7
<212> PRT
<213> human

<400> 79
Val Glu Glu Ala Pro Val Lys 
1               5           

<210> 80
<211> 40
<212> PRT
<213> human

<400> 80
Val Leu Ile Ile Ser Thr Ser Thr Thr Asn Asp Tyr Thr Pro Gln Val 
1               5                   10                  15      
Ser Ala Ile Thr Asp Val Glu Gly Gly Leu Ser Asp Ala Leu Arg Thr 
            20                  25                  30          
Glu Glu Asn Met Glu Gly Thr Arg 
        35                  40  

<210> 81
<211> 25
<212> PRT
<213> human

<400> 81
Val Thr Thr Glu Glu Phe Glu Ala Pro Met Pro Ser Ala Val Ser Gly 
1               5                   10                  15      
Asp Asp Ser Gln Leu Thr Ala Ser Arg 
            20                  25  

<210> 82
<211> 16
<212> PRT
<213> human

<400> 82
Ala Asn Pro Gly Arg Asp Leu Leu Glu Leu Leu Thr Glu Val Asn Arg 
1               5                   10                  15      



<210> 83
<211> 24
<212> PRT
<213> human

<400> 83
Gly Leu Gly Tyr Gly Cys Gly Gly Phe Gly Gly Leu Gly Tyr Gly Tyr 
1               5                   10                  15      
Gly Cys Gly Cys Gly Ser Phe Arg 
            20                  

<210> 84
<211> 15
<212> PRT
<213> human

<400> 84
Gln Thr Ala Leu Ile Ala Ile Pro Met Ser Ser Gln Thr Pro Arg 
1               5                   10                  15  

<210> 85
<211> 17
<212> PRT
<213> human

<400> 85
Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Met Asn Ser 
1               5                   10                  15      
Arg 
    

<210> 86
<211> 6
<212> PRT
<213> human

<400> 86
Gln Glu Val Glu Val Lys 
1               5       

<210> 87
<211> 11
<212> PRT
<213> human

<400> 87
Asp Ser Ala Trp Asp Pro Ser Gln Thr Met Lys 
1               5                   10      

<210> 88
<211> 12
<212> PRT
<213> human

<400> 88
Asp Thr Ser Val Leu Thr Phe Thr Phe Cys Phe Lys 
1               5                   10          

<210> 89
<211> 24
<212> PRT
<213> human

<400> 89
Asn Cys Asp Ala Leu Leu His His Ser Ala Ile Pro Glu Asp Phe Leu 
1               5                   10                  15      
His Ile Phe Leu Leu Leu Gln Lys 
            20                  

<210> 90
<211> 28
<212> PRT
<213> human

<400> 90
Glu Gln Asp Ala Leu Trp Gln Gly Leu Glu Leu Leu Gln His Gly Gln 
1               5                   10                  15      
Ala Trp Phe Glu Asp His Leu Arg Glu Ala Gln Arg 
            20                  25              

<210> 91
<211> 48
<212> PRT
<213> human

<400> 91
Leu Ser Cys Ile Asp Thr Thr Ile Asn Glu Ile Ile Asn Tyr Gly Val 
1               5                   10                  15      
Ser Ser Phe Val Ile Phe Val Pro Ile Gly Leu Ile Phe Ile Ser Tyr 
            20                  25                  30          
Val Leu Val Ile Ser Ser Ile Leu Gln Ile Ala Ser Ala Glu Gly Arg 
        35                  40                  45              



<210> 92
<211> 49
<212> PRT
<213> human

<400> 92
Leu Ser Cys Ile Asp Thr Thr Ile Asn Glu Ile Ile Asn Tyr Gly Val 
1               5                   10                  15      
Ser Ser Phe Val Ile Phe Val Pro Ile Gly Leu Ile Phe Ile Ser Tyr 
            20                  25                  30          
Val Leu Val Ile Ser Ser Ile Leu Gln Ile Ala Ser Ala Glu Gly Arg 
        35                  40                  45              
Lys 
    

<210> 93
<211> 27
<212> PRT
<213> human

<400> 93
Thr Phe Ala Thr Cys Val Ser His Leu Thr Val Val Ile Val His Cys 
1               5                   10                  15      
Gly Cys Ala Ser Ile Ala Tyr Leu Lys Pro Lys 
            20                  25          

<210> 94
<211> 7
<212> PRT
<213> human

<400> 94
Tyr Thr Val Ile Met Ser Lys 
1               5           

<210> 95
<211> 7
<212> PRT
<213> human

<400> 95
Glu Phe Ile Pro Gly Glu Lys 
1               5           

<210> 96
<211> 16
<212> PRT
<213> human

<400> 96
Met Asn Gly Ser Asn Met Ala Asn Thr Ser Pro Ser Val Lys Ser Lys 
1               5                   10                  15      



<210> 97
<211> 12
<212> PRT
<213> human

<400> 97
Glu Ala Phe Thr Pro Glu Gln Leu His Leu Glu Lys 
1               5                   10          

<210> 98
<211> 22
<212> PRT
<213> human

<400> 98
Leu Gly Tyr Gly Gly Gly Tyr Gly Gly Tyr Gly Tyr Gly Ser Gly Phe 
1               5                   10                  15      
Gly Gly Tyr Gly Tyr Arg 
            20          

<210> 99
<211> 6
<212> PRT
<213> human

<400> 99
Asp Glu Ser Leu Tyr Arg 
1               5       

<210> 100
<211> 5
<212> PRT
<213> human

<400> 100
Thr Pro Leu Leu Lys 
1               5   

<210> 101
<211> 12
<212> PRT
<213> human

<400> 101
Val Pro Asn Phe Ile Gly Gln Tyr Tyr Lys Trp Lys 
1               5                   10          

<210> 102
<211> 18
<212> PRT
<213> human

<400> 102
Gly Glu Leu Ala Ala Ser Ala Asn His Gly His Ser Pro Cys Tyr Pro 
1               5                   10                  15      
Glu Arg 
        

<210> 103
<211> 10
<212> PRT
<213> human

<400> 103
Ala Leu Glu Leu Glu Gly Ala Pro Ala Lys 
1               5                   10  

<210> 104
<211> 26
<212> PRT
<213> human

<400> 104
Leu Leu Thr Leu Glu Gln Pro Gln Gly Asp Ser Met Met Thr Cys Glu 
1               5                   10                  15      
Gln Ala Gln Leu Leu Ala Asn Leu Ala Arg 
            20                  25      

<210> 105
<211> 19
<212> PRT
<213> human

<400> 105
Lys Cys Leu Phe Thr His Asn Ile Tyr Leu Gln Asp Val Gln Met Val 
1               5                   10                  15      
His Pro Lys 
            

<210> 106
<211> 4
<212> PRT
<213> human

<400> 106
Glu Leu Asp Lys 
1               

<210> 107
<211> 13
<212> PRT
<213> human

<400> 107
Phe Pro Pro Ser Leu Ser Glu Thr Asn Lys Gly Leu Arg 
1               5                   10              

<210> 108
<211> 17
<212> PRT
<213> human

<400> 108
Gly Leu Ile Pro Ala Gly Thr Gln His Ser Met Ile Ala Thr Thr Gly 
1               5                   10                  15      
Lys 
    

<210> 109
<211> 22
<212> PRT
<213> human

<400> 109
Gly Ser Glu Thr Asp Thr Asp Ser Glu Ile His Glu Ser Ala Ser Asp 
1               5                   10                  15      
Lys Asp Ser Leu Ser Lys 
            20          

<210> 110
<211> 4
<212> PRT
<213> human

<400> 110
Leu Glu Glu Lys 
1               

<210> 111
<211> 5
<212> PRT
<213> human

<400> 111
Met Glu Glu Gln Arg 
1               5   

<210> 112
<211> 30
<212> PRT
<213> human

<400> 112
Asp Ile Gln Met Thr Gln Ser Pro Ser Pro Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Ser Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Arg 
            20                  25                  30  

<210> 113
<211> 16
<212> PRT
<213> human

<400> 113
Phe Leu Ile Tyr Asp Ala Glu Asn Leu Glu Ile Gly Val Pro Ser Arg 
1               5                   10                  15      



<210> 114
<211> 13
<212> PRT
<213> human

<400> 114
Met Ser Tyr Asn Cys Cys Ser Gly Asn Phe Ser Ser Arg 
1               5                   10              

<210> 115
<211> 7
<212> PRT
<213> human

<400> 115
Leu Gly His Asn Glu Leu Lys 
1               5           

<210> 116
<211> 11
<212> PRT
<213> human

<400> 116
Leu Gly His Asn Glu Leu Lys Glu Cys Leu Lys 
1               5                   10      

<210> 117
<211> 147
<212> PRT
<213> human

<400> 117
Met Val His Phe Thr Ala Glu Glu Lys Ala Ala Val Thr Ser Leu Trp 
1               5                   10                  15      
Ser Lys Met Asn Val Glu Glu Ala Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          
Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn 
        35                  40                  45              
Leu Ser Ser Pro Ser Ala Ile Leu Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  
Gly Lys Lys Val Leu Thr Ser Phe Gly Asp Ala Ile Lys Asn Met Asp 
65                  70                  75                  80  
Asn Leu Lys Pro Ala Phe Ala Lys Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      
Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Val Met Val 
            100                 105                 110         
Ile Ile Leu Ala Thr His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             
Ala Ala Trp Gln Lys Leu Val Ser Ala Val Ala Ile Ala Leu Ala His 
    130                 135                 140                 
Lys Tyr His 
145         

<210> 118
<211> 3580
<212> PRT
<213> human

<400> 118
Met Glu Ser Asn Phe Asn Gln Glu Gly Val Pro Arg Pro Ser Tyr Val 
1               5                   10                  15      
Phe Ser Ala Asp Pro Ile Ala Arg Pro Ser Glu Ile Asn Phe Asp Gly 
            20                  25                  30          
Ile Lys Leu Asp Leu Ser His Glu Phe Ser Leu Val Ala Pro Asn Thr 
        35                  40                  45              
Glu Ala Asn Ser Phe Glu Ser Lys Asp Tyr Leu Gln Val Cys Leu Arg 
    50                  55                  60                  
Ile Arg Pro Phe Thr Gln Ser Glu Lys Glu Leu Glu Ser Glu Gly Cys 
65                  70                  75                  80  
Val His Ile Leu Asp Ser Gln Thr Val Val Leu Lys Glu Pro Gln Cys 
                85                  90                  95      
Ile Leu Gly Arg Leu Ser Glu Lys Ser Ser Gly Gln Met Ala Gln Lys 
            100                 105                 110         
Phe Ser Phe Ser Lys Val Phe Gly Pro Ala Thr Thr Gln Lys Glu Phe 
        115                 120                 125             
Phe Gln Gly Cys Ile Met Gln Pro Val Lys Asp Leu Leu Lys Gly Gln 
    130                 135                 140                 
Ser Arg Leu Ile Phe Thr Tyr Gly Leu Thr Asn Ser Gly Lys Thr Tyr 
145                 150                 155                 160 
Thr Phe Gln Gly Thr Glu Glu Asn Ile Gly Ile Leu Pro Arg Thr Leu 
                165                 170                 175     
Asn Val Leu Phe Asp Ser Leu Gln Glu Arg Leu Tyr Thr Lys Met Asn 
            180                 185                 190         
Leu Lys Pro His Arg Ser Arg Glu Tyr Leu Arg Leu Ser Ser Glu Gln 
        195                 200                 205             
Glu Lys Glu Glu Ile Ala Ser Lys Ser Ala Leu Leu Arg Gln Ile Lys 
    210                 215                 220                 
Glu Val Thr Val His Asn Asp Ser Asp Asp Thr Leu Tyr Gly Ser Leu 
225                 230                 235                 240 
Thr Asn Ser Leu Asn Ile Ser Glu Phe Glu Glu Ser Ile Lys Asp Tyr 
                245                 250                 255     
Glu Gln Ala Asn Leu Asn Met Ala Asn Ser Ile Lys Phe Ser Val Trp 
            260                 265                 270         
Val Ser Phe Phe Glu Ile Tyr Asn Glu Tyr Ile Tyr Asp Leu Phe Val 
        275                 280                 285             
Pro Val Ser Ser Lys Phe Gln Lys Arg Lys Met Leu Arg Leu Ser Gln 
    290                 295                 300                 
Asp Val Lys Gly Tyr Ser Phe Ile Lys Asp Leu Gln Trp Ile Gln Val 
305                 310                 315                 320 
Ser Asp Ser Lys Glu Ala Tyr Arg Leu Leu Lys Leu Gly Ile Lys His 
                325                 330                 335     
Gln Ser Val Ala Phe Thr Lys Leu Asn Asn Ala Ser Ser Arg Ser His 
            340                 345                 350         
Ser Ile Phe Thr Val Lys Ile Leu Gln Ile Glu Asp Ser Glu Met Ser 
        355                 360                 365             
Arg Val Ile Arg Val Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser 
    370                 375                 380                 
Glu Arg Thr Met Lys Thr Gln Asn Glu Gly Glu Arg Leu Arg Glu Thr 
385                 390                 395                 400 
Gly Asn Ile Asn Thr Ser Leu Leu Thr Leu Gly Lys Cys Ile Asn Val 
                405                 410                 415     
Leu Lys Asn Ser Glu Lys Ser Lys Phe Gln Gln His Val Pro Phe Arg 
            420                 425                 430         
Glu Ser Lys Leu Thr His Tyr Phe Gln Ser Phe Phe Asn Gly Lys Gly 
        435                 440                 445             
Lys Ile Cys Met Ile Val Asn Ile Ser Gln Cys Tyr Leu Ala Tyr Asp 
    450                 455                 460                 
Glu Thr Leu Asn Val Leu Lys Phe Ser Ala Ile Ala Gln Lys Val Cys 
465                 470                 475                 480 
Val Pro Asp Thr Leu Asn Ser Ser Gln Glu Lys Leu Phe Gly Pro Val 
                485                 490                 495     
Lys Ser Ser Gln Asp Val Ser Leu Asp Ser Asn Ser Asn Ser Lys Ile 
            500                 505                 510         
Leu Asn Val Lys Arg Ala Thr Ile Ser Trp Glu Asn Ser Leu Glu Asp 
        515                 520                 525             
Leu Met Glu Asp Glu Asp Leu Val Glu Glu Leu Glu Asn Ala Glu Glu 
    530                 535                 540                 
Thr Gln Asn Val Glu Thr Lys Leu Leu Asp Glu Asp Leu Asp Lys Thr 
545                 550                 555                 560 
Leu Glu Glu Asn Lys Ala Phe Ile Ser His Glu Glu Lys Arg Lys Leu 
                565                 570                 575     
Leu Asp Leu Ile Glu Asp Leu Lys Lys Lys Leu Ile Asn Glu Lys Lys 
            580                 585                 590         
Glu Lys Leu Thr Leu Glu Phe Lys Ile Arg Glu Glu Val Thr Gln Glu 
        595                 600                 605             
Phe Thr Gln Tyr Trp Ala Gln Arg Glu Ala Asp Phe Lys Glu Thr Leu 
    610                 615                 620                 
Leu Gln Glu Arg Glu Ile Leu Glu Glu Asn Ala Glu Arg Arg Leu Ala 
625                 630                 635                 640 
Ile Phe Lys Asp Leu Val Gly Lys Cys Asp Thr Arg Glu Glu Ala Ala 
                645                 650                 655     
Lys Asp Ile Cys Ala Thr Lys Val Glu Thr Glu Glu Thr His Asn Tyr 
            660                 665                 670         
Val Gly Phe Glu Asp Ile Ile Asp Ser Leu Gln Asp Asn Val Ala Asp 
        675                 680                 685             
Ile Lys Lys Gln Ala Glu Ile Ala His Leu Tyr Ile Ala Ser Leu Pro 
    690                 695                 700                 
Asp Pro Gln Glu Ala Thr Ala Cys Leu Glu Leu Lys Phe Asn Gln Ile 
705                 710                 715                 720 
Lys Ala Glu Leu Ala Lys Thr Lys Gly Glu Leu Ile Lys Thr Lys Glu 
                725                 730                 735     
Glu Leu Lys Lys Arg Glu Asn Glu Ser Asp Ser Leu Ile Gln Glu Leu 
            740                 745                 750         
Glu Thr Ser Asn Lys Lys Ile Ile Thr Gln Asn Gln Arg Ile Lys Glu 
        755                 760                 765             
Leu Ile Asn Ile Ile Asp Gln Lys Glu Asp Thr Ile Asn Glu Phe Gln 
    770                 775                 780                 
Asn Leu Lys Ser His Met Glu Asn Thr Phe Lys Cys Asn Asp Lys Ala 
785                 790                 795                 800 
Asp Thr Ser Ser Leu Ile Ile Asn Asn Lys Leu Ile Cys Asn Glu Thr 
                805                 810                 815     
Val Glu Val Pro Lys Asp Ser Lys Ser Lys Ile Cys Ser Glu Arg Lys 
            820                 825                 830         
Arg Val Asn Glu Asn Glu Leu Gln Gln Asp Glu Pro Pro Ala Lys Lys 
        835                 840                 845             
Gly Ser Ile His Val Ser Ser Ala Ile Thr Glu Asp Gln Lys Lys Ser 
    850                 855                 860                 
Glu Glu Val Arg Pro Asn Ile Ala Glu Ile Glu Asp Ile Arg Val Leu 
865                 870                 875                 880 
Gln Glu Asn Asn Glu Gly Leu Arg Ala Phe Leu Leu Thr Ile Glu Asn 
                885                 890                 895     
Glu Leu Lys Asn Glu Lys Glu Glu Lys Ala Glu Leu Asn Lys Gln Ile 
            900                 905                 910         
Val His Phe Gln Gln Glu Leu Ser Leu Ser Glu Lys Lys Asn Leu Thr 
        915                 920                 925             
Leu Ser Lys Glu Val Gln Gln Ile Gln Ser Asn Tyr Asp Ile Ala Ile 
    930                 935                 940                 
Ala Glu Leu His Val Gln Lys Ser Lys Asn Gln Glu Gln Glu Glu Lys 
945                 950                 955                 960 
Ile Met Lys Leu Ser Asn Glu Ile Glu Thr Ala Thr Arg Ser Ile Thr 
                965                 970                 975     
Asn Asn Val Ser Gln Ile Lys Leu Met His Thr Lys Ile Asp Glu Leu 
            980                 985                 990         
Arg Thr Leu Asp Ser Val Ser Gln Ile Ser Asn Ile Asp Leu Leu Asn 
        995                 1000                1005            
Leu Arg Asp Leu Ser Asn Gly Ser Glu Glu Asp Asn Leu Pro Asn Thr 
    1010                1015                1020                
Gln Leu Asp Leu Leu Gly Asn Asp Tyr Leu Val Ser Lys Gln Val Lys 
1025                1030                1035                1040
Glu Tyr Arg Ile Gln Glu Pro Asn Arg Glu Asn Ser Phe His Ser Ser 
                1045                1050                1055    
Ile Glu Ala Ile Trp Glu Glu Cys Lys Glu Ile Val Lys Ala Ser Ser 
            1060                1065                1070        
Lys Lys Ser His Gln Ile Glu Glu Leu Glu Gln Gln Ile Glu Lys Leu 
        1075                1080                1085            
Gln Ala Glu Val Lys Gly Tyr Lys Asp Glu Asn Asn Arg Leu Lys Glu 
    1090                1095                1100                
Lys Glu His Lys Asn Gln Asp Asp Leu Leu Lys Glu Lys Glu Thr Leu 
1105                1110                1115                1120
Ile Gln Gln Leu Lys Glu Glu Leu Gln Glu Lys Asn Val Thr Leu Asp 
                1125                1130                1135    
Val Gln Ile Gln His Val Val Glu Gly Lys Arg Ala Leu Ser Glu Leu 
            1140                1145                1150        
Thr Gln Gly Val Thr Cys Tyr Lys Ala Lys Ile Lys Glu Leu Glu Thr 
        1155                1160                1165            
Ile Leu Glu Thr Gln Lys Val Glu Cys Ser His Ser Ala Lys Leu Glu 
    1170                1175                1180                
Gln Asp Ile Leu Glu Lys Glu Ser Ile Ile Leu Lys Leu Glu Arg Asn 
1185                1190                1195                1200
Leu Lys Glu Phe Gln Glu His Leu Gln Asp Ser Val Lys Asn Thr Lys 
                1205                1210                1215    
Asp Leu Asn Val Lys Glu Leu Lys Leu Lys Glu Glu Ile Thr Gln Leu 
            1220                1225                1230        
Thr Asn Asn Leu Gln Asp Met Lys His Leu Leu Gln Leu Lys Glu Glu 
        1235                1240                1245            
Glu Glu Glu Thr Asn Arg Gln Glu Thr Glu Lys Leu Lys Glu Glu Leu 
    1250                1255                1260                
Ser Ala Ser Ser Ala Arg Thr Gln Asn Leu Lys Ala Asp Leu Gln Arg 
1265                1270                1275                1280
Lys Glu Glu Asp Tyr Ala Asp Leu Lys Glu Lys Leu Thr Asp Ala Lys 
                1285                1290                1295    
Lys Gln Ile Lys Gln Val Gln Lys Glu Val Ser Val Met Arg Asp Glu 
            1300                1305                1310        
Asp Lys Leu Leu Arg Ile Lys Ile Asn Glu Leu Glu Lys Lys Lys Asn 
        1315                1320                1325            
Gln Cys Ser Gln Glu Leu Asp Met Lys Gln Arg Thr Ile Gln Gln Leu 
    1330                1335                1340                
Lys Glu Gln Leu Asn Asn Gln Lys Val Glu Glu Ala Ile Gln Gln Tyr 
1345                1350                1355                1360
Glu Arg Ala Cys Lys Asp Leu Asn Val Lys Glu Lys Ile Ile Glu Asp 
                1365                1370                1375    
Met Arg Met Thr Leu Glu Glu Gln Glu Gln Thr Gln Val Glu Gln Asp 
            1380                1385                1390        
Gln Val Leu Glu Ala Lys Leu Glu Glu Val Glu Arg Leu Ala Thr Glu 
        1395                1400                1405            
Leu Glu Lys Trp Lys Glu Lys Cys Asn Asp Leu Glu Thr Lys Asn Asn 
    1410                1415                1420                
Gln Arg Ser Asn Lys Glu His Glu Asn Asn Thr Asp Val Leu Gly Lys 
1425                1430                1435                1440
Leu Thr Asn Leu Gln Asp Glu Leu Gln Glu Ser Glu Gln Lys Tyr Asn 
                1445                1450                1455    
Ala Asp Arg Lys Lys Trp Leu Glu Glu Lys Met Met Leu Ile Thr Gln 
            1460                1465                1470        
Ala Lys Glu Ala Glu Asn Ile Arg Asn Lys Glu Met Lys Lys Tyr Ala 
        1475                1480                1485            
Glu Asp Arg Glu Arg Phe Phe Lys Gln Gln Asn Glu Met Glu Ile Leu 
    1490                1495                1500                
Thr Ala Gln Leu Thr Glu Lys Asp Ser Asp Leu Gln Lys Trp Arg Glu 
1505                1510                1515                1520
Glu Arg Asp Gln Leu Val Ala Ala Leu Glu Ile Gln Leu Lys Ala Leu 
                1525                1530                1535    
Ile Ser Ser Asn Val Gln Lys Asp Asn Glu Ile Glu Gln Leu Lys Arg 
            1540                1545                1550        
Ile Ile Ser Glu Thr Ser Lys Ile Glu Thr Gln Ile Met Asp Ile Lys 
        1555                1560                1565            
Pro Lys Arg Ile Ser Ser Ala Asp Pro Asp Lys Leu Gln Thr Glu Pro 
    1570                1575                1580                
Leu Ser Thr Ser Phe Glu Ile Ser Arg Asn Lys Ile Glu Asp Gly Ser 
1585                1590                1595                1600
Val Val Leu Asp Ser Cys Glu Val Ser Thr Glu Asn Asp Gln Ser Thr 
                1605                1610                1615    
Arg Phe Pro Lys Pro Glu Leu Glu Ile Gln Phe Thr Pro Leu Gln Pro 
            1620                1625                1630        
Asn Lys Met Ala Val Lys His Pro Gly Cys Thr Thr Pro Val Thr Val 
        1635                1640                1645            
Lys Ile Pro Lys Ala Arg Lys Arg Lys Ser Asn Glu Met Glu Glu Asp 
    1650                1655                1660                
Leu Val Lys Cys Glu Asn Lys Lys Asn Ala Thr Pro Arg Thr Asn Leu 
1665                1670                1675                1680
Lys Phe Pro Ile Ser Asp Asp Arg Asn Ser Ser Val Lys Lys Glu Gln 
                1685                1690                1695    
Lys Val Ala Ile Arg Pro Ser Ser Lys Lys Thr Tyr Ser Leu Arg Ser 
            1700                1705                1710        
Gln Ala Ser Ile Ile Gly Val Asn Leu Ala Thr Lys Lys Lys Glu Gly 
        1715                1720                1725            
Thr Leu Gln Lys Phe Gly Asp Phe Leu Gln His Ser Pro Ser Ile Leu 
    1730                1735                1740                
Gln Ser Lys Ala Lys Lys Ile Ile Glu Thr Met Ser Ser Ser Lys Leu 
1745                1750                1755                1760
Ser Asn Val Glu Ala Ser Lys Glu Asn Val Ser Gln Pro Lys Arg Ala 
                1765                1770                1775    
Lys Arg Lys Leu Tyr Thr Ser Glu Ile Ser Ser Pro Ile Asp Ile Ser 
            1780                1785                1790        
Gly Gln Val Ile Leu Met Asp Gln Lys Met Lys Glu Ser Asp His Gln 
        1795                1800                1805            
Ile Ile Lys Arg Arg Leu Arg Thr Lys Thr Ala Lys Val Cys Leu Arg 
    1810                1815                1820                
Ile Arg Pro Phe Thr Gln Ser Glu Lys Glu Leu Glu Ser Glu Gly Cys 
1825                1830                1835                1840
Val His Ile Leu Asp Ser Gln Thr Val Val Leu Lys Glu Pro Gln Cys 
                1845                1850                1855    
Ile Leu Gly Arg Leu Ser Glu Lys Ser Ser Gly Gln Met Ala Gln Lys 
            1860                1865                1870        
Phe Ser Phe Ser Lys Val Phe Gly Pro Ala Thr Thr Gln Lys Glu Phe 
        1875                1880                1885            
Phe Gln Gly Cys Ile Met Gln Pro Val Lys Asp Leu Leu Lys Gly Gln 
    1890                1895                1900                
Ser Arg Leu Ile Phe Thr Tyr Gly Leu Thr Asn Ser Gly Lys Thr Tyr 
1905                1910                1915                1920
Thr Phe Gln Gly Thr Glu Glu Asn Ile Gly Ile Leu Pro Arg Thr Leu 
                1925                1930                1935    
Asn Val Leu Phe Asp Ser Leu Gln Glu Arg Leu Tyr Thr Lys Met Asn 
            1940                1945                1950        
Leu Lys Pro His Arg Ser Arg Glu Tyr Leu Arg Leu Ser Ser Glu Gln 
        1955                1960                1965            
Glu Lys Glu Glu Ile Ala Ser Lys Ser Ala Leu Leu Arg Gln Ile Lys 
    1970                1975                1980                
Glu Val Thr Val His Asn Asp Ser Asp Asp Thr Leu Tyr Gly Ser Leu 
1985                1990                1995                2000
Thr Asn Ser Leu Asn Ile Ser Glu Phe Glu Glu Ser Ile Lys Asp Tyr 
                2005                2010                2015    
Glu Gln Ala Asn Leu Asn Met Ala Asn Ser Ile Lys Phe Ser Val Trp 
            2020                2025                2030        
Val Ser Phe Phe Glu Ile Tyr Asn Glu Tyr Ile Tyr Asp Leu Phe Val 
        2035                2040                2045            
Pro Val Ser Ser Lys Phe Gln Lys Arg Lys Met Leu Arg Leu Ser Gln 
    2050                2055                2060                
Asp Val Lys Gly Tyr Ser Phe Ile Lys Asp Leu Gln Trp Ile Gln Val 
2065                2070                2075                2080
Ser Asp Ser Lys Glu Ala Tyr Arg Leu Leu Lys Leu Gly Ile Lys His 
                2085                2090                2095    
Gln Ser Val Ala Phe Thr Lys Leu Asn Asn Ala Ser Ser Arg Ser His 
            2100                2105                2110        
Ser Ile Phe Thr Val Lys Ile Leu Gln Ile Glu Asp Ser Glu Met Ser 
        2115                2120                2125            
Arg Val Ile Arg Val Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser 
    2130                2135                2140                
Glu Arg Thr Met Lys Thr Gln Asn Glu Gly Glu Arg Leu Arg Glu Thr 
2145                2150                2155                2160
Gly Asn Ile Asn Thr Ser Leu Leu Thr Leu Gly Lys Cys Ile Asn Val 
                2165                2170                2175    
Leu Lys Asn Ser Glu Lys Ser Lys Phe Gln Gln His Val Pro Phe Arg 
            2180                2185                2190        
Glu Ser Lys Leu Thr His Tyr Phe Gln Ser Phe Phe Asn Gly Lys Gly 
        2195                2200                2205            
Lys Ile Cys Met Ile Val Asn Ile Ser Gln Cys Tyr Leu Ala Tyr Asp 
    2210                2215                2220                
Glu Thr Leu Asn Val Leu Lys Phe Ser Ala Ile Ala Gln Lys Val Cys 
2225                2230                2235                2240
Val Pro Asp Thr Leu Asn Ser Ser Gln Glu Lys Leu Phe Gly Pro Val 
                2245                2250                2255    
Lys Ser Ser Gln Asp Val Ser Leu Asp Ser Asn Ser Asn Ser Lys Ile 
            2260                2265                2270        
Leu Asn Val Lys Arg Ala Thr Ile Ser Trp Glu Asn Ser Leu Glu Asp 
        2275                2280                2285            
Leu Met Glu Asp Glu Asp Leu Val Glu Glu Leu Glu Asn Ala Glu Glu 
    2290                2295                2300                
Thr Gln Asn Val Glu Thr Lys Leu Leu Asp Glu Asp Leu Asp Lys Thr 
2305                2310                2315                2320
Leu Glu Glu Asn Lys Ala Phe Ile Ser His Glu Glu Lys Arg Lys Leu 
                2325                2330                2335    
Leu Asp Leu Ile Glu Asp Leu Lys Lys Lys Leu Ile Asn Glu Lys Lys 
            2340                2345                2350        
Glu Lys Leu Thr Leu Glu Phe Lys Ile Arg Glu Glu Val Thr Gln Glu 
        2355                2360                2365            
Phe Thr Gln Tyr Trp Ala Gln Arg Glu Ala Asp Phe Lys Glu Thr Leu 
    2370                2375                2380                
Leu Gln Glu Arg Glu Ile Leu Glu Glu Asn Ala Glu Arg Arg Leu Ala 
2385                2390                2395                2400
Ile Phe Lys Asp Leu Val Gly Lys Cys Asp Thr Arg Glu Glu Ala Ala 
                2405                2410                2415    
Lys Asp Ile Cys Ala Thr Lys Val Glu Thr Glu Glu Thr His Asn Tyr 
            2420                2425                2430        
Val Gly Phe Glu Asp Ile Ile Asp Ser Leu Gln Asp Asn Val Ala Asp 
        2435                2440                2445            
Ile Lys Lys Gln Ala Glu Ile Ala His Leu Tyr Ile Ala Ser Leu Pro 
    2450                2455                2460                
Asp Pro Gln Glu Ala Thr Ala Cys Leu Glu Leu Lys Phe Asn Gln Ile 
2465                2470                2475                2480
Lys Ala Glu Leu Ala Lys Thr Lys Gly Glu Leu Ile Lys Thr Lys Glu 
                2485                2490                2495    
Glu Leu Lys Lys Arg Glu Asn Glu Ser Asp Ser Leu Ile Gln Glu Leu 
            2500                2505                2510        
Glu Thr Ser Asn Lys Lys Ile Ile Thr Gln Asn Gln Arg Ile Lys Glu 
        2515                2520                2525            
Leu Ile Asn Ile Ile Asp Gln Lys Glu Asp Thr Ile Asn Glu Phe Gln 
    2530                2535                2540                
Asn Leu Lys Ser His Met Glu Asn Thr Phe Lys Cys Asn Asp Lys Ala 
2545                2550                2555                2560
Asp Thr Ser Ser Leu Ile Ile Asn Asn Lys Leu Ile Cys Asn Glu Thr 
                2565                2570                2575    
Val Glu Val Pro Lys Asp Ser Lys Ser Lys Ile Cys Ser Glu Arg Lys 
            2580                2585                2590        
Arg Val Asn Glu Asn Glu Leu Gln Gln Asp Glu Pro Pro Ala Lys Lys 
        2595                2600                2605            
Gly Ser Ile His Val Ser Ser Ala Ile Thr Glu Asp Gln Lys Lys Ser 
    2610                2615                2620                
Glu Glu Val Arg Pro Asn Ile Ala Glu Ile Glu Asp Ile Arg Val Leu 
2625                2630                2635                2640
Gln Glu Asn Asn Glu Gly Leu Arg Ala Phe Leu Leu Thr Ile Glu Asn 
                2645                2650                2655    
Glu Leu Lys Asn Glu Lys Glu Glu Lys Ala Glu Leu Asn Lys Gln Ile 
            2660                2665                2670        
Val His Phe Gln Gln Glu Leu Ser Leu Ser Glu Lys Lys Asn Leu Thr 
        2675                2680                2685            
Leu Ser Lys Glu Val Gln Gln Ile Gln Ser Asn Tyr Asp Ile Ala Ile 
    2690                2695                2700                
Ala Glu Leu His Val Gln Lys Ser Lys Asn Gln Glu Gln Glu Glu Lys 
2705                2710                2715                2720
Ile Met Lys Leu Ser Asn Glu Ile Glu Thr Ala Thr Arg Ser Ile Thr 
                2725                2730                2735    
Asn Asn Val Ser Gln Ile Lys Leu Met His Thr Lys Ile Asp Glu Leu 
            2740                2745                2750        
Arg Thr Leu Asp Ser Val Ser Gln Ile Ser Asn Ile Asp Leu Leu Asn 
        2755                2760                2765            
Leu Arg Asp Leu Ser Asn Gly Ser Glu Glu Asp Asn Leu Pro Asn Thr 
    2770                2775                2780                
Gln Leu Asp Leu Leu Gly Asn Asp Tyr Leu Val Ser Lys Gln Val Lys 
2785                2790                2795                2800
Glu Tyr Arg Ile Gln Glu Pro Asn Arg Glu Asn Ser Phe His Ser Ser 
                2805                2810                2815    
Ile Glu Ala Ile Trp Glu Glu Cys Lys Glu Ile Val Lys Ala Ser Ser 
            2820                2825                2830        
Lys Lys Ser His Gln Ile Glu Glu Leu Glu Gln Gln Ile Glu Lys Leu 
        2835                2840                2845            
Gln Ala Glu Val Lys Gly Tyr Lys Asp Glu Asn Asn Arg Leu Lys Glu 
    2850                2855                2860                
Lys Glu His Lys Asn Gln Asp Asp Leu Leu Lys Glu Lys Glu Thr Leu 
2865                2870                2875                2880
Ile Gln Gln Leu Lys Glu Glu Leu Gln Glu Lys Asn Val Thr Leu Asp 
                2885                2890                2895    
Val Gln Ile Gln His Val Val Glu Gly Lys Arg Ala Leu Ser Glu Leu 
            2900                2905                2910        
Thr Gln Gly Val Thr Cys Tyr Lys Ala Lys Ile Lys Glu Leu Glu Thr 
        2915                2920                2925            
Ile Leu Glu Thr Gln Lys Val Glu Cys Ser His Ser Ala Lys Leu Glu 
    2930                2935                2940                
Gln Asp Ile Leu Glu Lys Glu Ser Ile Ile Leu Lys Leu Glu Arg Asn 
2945                2950                2955                2960
Leu Lys Glu Phe Gln Glu His Leu Gln Asp Ser Val Lys Asn Thr Lys 
                2965                2970                2975    
Asp Leu Asn Val Lys Glu Leu Lys Leu Lys Glu Glu Ile Thr Gln Leu 
            2980                2985                2990        
Thr Asn Asn Leu Gln Asp Met Lys His Leu Leu Gln Leu Lys Glu Glu 
        2995                3000                3005            
Glu Glu Glu Thr Asn Arg Gln Glu Thr Glu Lys Leu Lys Glu Glu Leu 
    3010                3015                3020                
Ser Ala Ser Ser Ala Arg Thr Gln Asn Leu Lys Ala Asp Leu Gln Arg 
3025                3030                3035                3040
Lys Glu Glu Asp Tyr Ala Asp Leu Lys Glu Lys Leu Thr Asp Ala Lys 
                3045                3050                3055    
Lys Gln Ile Lys Gln Val Gln Lys Glu Val Ser Val Met Arg Asp Glu 
            3060                3065                3070        
Asp Lys Leu Leu Arg Ile Lys Ile Asn Glu Leu Glu Lys Lys Lys Asn 
        3075                3080                3085            
Gln Cys Ser Gln Glu Leu Asp Met Lys Gln Arg Thr Ile Gln Gln Leu 
    3090                3095                3100                
Lys Glu Gln Leu Asn Asn Gln Lys Val Glu Glu Ala Ile Gln Gln Tyr 
3105                3110                3115                3120
Glu Arg Ala Cys Lys Asp Leu Asn Val Lys Glu Lys Ile Ile Glu Asp 
                3125                3130                3135    
Met Arg Met Thr Leu Glu Glu Gln Glu Gln Thr Gln Val Glu Gln Asp 
            3140                3145                3150        
Gln Val Leu Glu Ala Lys Leu Glu Glu Val Glu Arg Leu Ala Thr Glu 
        3155                3160                3165            
Leu Glu Lys Trp Lys Glu Lys Cys Asn Asp Leu Glu Thr Lys Asn Asn 
    3170                3175                3180                
Gln Arg Ser Asn Lys Glu His Glu Asn Asn Thr Asp Val Leu Gly Lys 
3185                3190                3195                3200
Leu Thr Asn Leu Gln Asp Glu Leu Gln Glu Ser Glu Gln Lys Tyr Asn 
                3205                3210                3215    
Ala Asp Arg Lys Lys Trp Leu Glu Glu Lys Met Met Leu Ile Thr Gln 
            3220                3225                3230        
Ala Lys Glu Ala Glu Asn Ile Arg Asn Lys Glu Met Lys Lys Tyr Ala 
        3235                3240                3245            
Glu Asp Arg Glu Arg Phe Phe Lys Gln Gln Asn Glu Met Glu Ile Leu 
    3250                3255                3260                
Thr Ala Gln Leu Thr Glu Lys Asp Ser Asp Leu Gln Lys Trp Arg Glu 
3265                3270                3275                3280
Glu Arg Asp Gln Leu Val Ala Ala Leu Glu Ile Gln Leu Lys Ala Leu 
                3285                3290                3295    
Ile Ser Ser Asn Val Gln Lys Asp Asn Glu Ile Glu Gln Leu Lys Arg 
            3300                3305                3310        
Ile Ile Ser Glu Thr Ser Lys Ile Glu Thr Gln Ile Met Asp Ile Lys 
        3315                3320                3325            
Pro Lys Arg Ile Ser Ser Ala Asp Pro Asp Lys Leu Gln Thr Glu Pro 
    3330                3335                3340                
Leu Ser Thr Ser Phe Glu Ile Ser Arg Asn Lys Ile Glu Asp Gly Ser 
3345                3350                3355                3360
Val Val Leu Asp Ser Cys Glu Val Ser Thr Glu Asn Asp Gln Ser Thr 
                3365                3370                3375    
Arg Phe Pro Lys Pro Glu Leu Glu Ile Gln Phe Thr Pro Leu Gln Pro 
            3380                3385                3390        
Asn Lys Met Ala Val Lys His Pro Gly Cys Thr Thr Pro Val Thr Val 
        3395                3400                3405            
Lys Ile Pro Lys Ala Arg Lys Arg Lys Ser Asn Glu Met Glu Glu Asp 
    3410                3415                3420                
Leu Val Lys Cys Glu Asn Lys Lys Asn Ala Thr Pro Arg Thr Asn Leu 
3425                3430                3435                3440
Lys Phe Pro Ile Ser Asp Asp Arg Asn Ser Ser Val Lys Lys Glu Gln 
                3445                3450                3455    
Lys Val Ala Ile Arg Pro Ser Ser Lys Lys Thr Tyr Ser Leu Arg Ser 
            3460                3465                3470        
Gln Ala Ser Ile Ile Gly Val Asn Leu Ala Thr Lys Lys Lys Glu Gly 
        3475                3480                3485            
Thr Leu Gln Lys Phe Gly Asp Phe Leu Gln His Ser Pro Ser Ile Leu 
    3490                3495                3500                
Gln Ser Lys Ala Lys Lys Ile Ile Glu Thr Met Ser Ser Ser Lys Leu 
3505                3510                3515                3520
Ser Asn Val Glu Ala Ser Lys Glu Asn Val Ser Gln Pro Lys Arg Ala 
                3525                3530                3535    
Lys Arg Lys Leu Tyr Thr Ser Glu Ile Ser Ser Pro Ile Asp Ile Ser 
            3540                3545                3550        
Gly Gln Val Ile Leu Met Asp Gln Lys Met Lys Glu Ser Asp His Gln 
        3555                3560                3565            
Ile Ile Lys Arg Arg Leu Arg Thr Lys Thr Ala Lys 
    3570                3575                3580

<210> 119
<211> 1677
<212> PRT
<213> human

<400> 119
Met Glu Val Pro Glu Pro Thr Cys Pro Ala Pro Pro Ala Arg Asp Gln 
1               5                   10                  15      
Pro Ala Pro Thr Pro Gly Pro Pro Gly Ala Pro Gly Gly Gln Ala Ser 
            20                  25                  30          
Pro His Leu Thr Leu Gly Pro Val Leu Leu Pro Pro Glu Gln Gly Leu 
        35                  40                  45              
Ala Pro Pro Thr Val Phe Leu Lys Ala Leu Pro Ile Pro Leu Tyr His 
    50                  55                  60                  
Thr Val Pro Pro Gly Gly Leu Gln Pro Arg Ala Pro Leu Val Thr Gly 
65                  70                  75                  80  
Ser Leu Asp Gly Gly Asn Val Pro Phe Ile Leu Ser Pro Val Leu Gln 
                85                  90                  95      
Pro Glu Gly Pro Gly Pro Thr Gln Val Gly Lys Pro Ala Ala Pro Thr 
            100                 105                 110         
Leu Thr Val Asn Ile Val Gly Thr Leu Pro Val Leu Ser Pro Gly Leu 
        115                 120                 125             
Gly Pro Thr Leu Gly Ser Pro Gly Lys Val Arg Asn Ala Gly Lys Tyr 
    130                 135                 140                 
Leu Cys Pro His Cys Gly Arg Asp Cys Leu Lys Pro Ser Val Leu Glu 
145                 150                 155                 160 
Lys His Ile Arg Ser His Thr Gly Glu Arg Pro Phe Pro Cys Ala Thr 
                165                 170                 175     
Cys Gly Ile Ala Phe Lys Thr Gln Ser Asn Leu Tyr Lys His Arg Arg 
            180                 185                 190         
Thr Gln Thr His Leu Asn Asn Ser Arg Leu Ser Ser Glu Ser Glu Gly 
        195                 200                 205             
Ala Gly Gly Gly Leu Leu Glu Glu Gly Asp Lys Ala Gly Glu Pro Pro 
    210                 215                 220                 
Arg Pro Glu Gly Arg Gly Glu Ser Arg Cys Gln Gly Met His Glu Gly 
225                 230                 235                 240 
Ala Ser Glu Arg Pro Leu Ser Pro Gly Ala His Val Pro Leu Leu Ala 
                245                 250                 255     
Lys Asn Leu Asp Val Arg Thr Glu Ala Ala Pro Cys Pro Gly Ser Ala 
            260                 265                 270         
Phe Ala Asp Arg Glu Ala Pro Trp Asp Ser Ala Pro Met Ala Ser Pro 
        275                 280                 285             
Gly Leu Pro Ala Ala Ser Thr Gln Pro Trp Arg Lys Leu Pro Glu Gln 
    290                 295                 300                 
Lys Ser Pro Thr Ala Gly Lys Pro Cys Ala Leu Gln Arg Gln Gln Ala 
305                 310                 315                 320 
Thr Ala Ala Glu Lys Pro Trp Asp Ala Lys Ala Pro Glu Gly Arg Leu 
                325                 330                 335     
Arg Lys Cys Glu Ser Thr Asp Ser Gly Tyr Leu Ser Arg Ser Asp Ser 
            340                 345                 350         
Ala Glu Gln Pro His Ala Pro Cys Ser Pro Leu His Ser Leu Ser Glu 
        355                 360                 365             
His Ser Ala Glu Ser Glu Gly Glu Gly Gly Pro Gly Pro Gly Pro Gly 
    370                 375                 380                 
Val Ala Gly Ala Glu Pro Gly Ala Arg Glu Ala Gly Leu Glu Leu Glu 
385                 390                 395                 400 
Lys Lys Arg Leu Glu Glu Arg Ile Ala Gln Leu Ile Ser His Asn Gln 
                405                 410                 415     
Ala Val Val Asp Asp Ala Gln Leu Asp Asn Val Arg Pro Arg Lys Thr 
            420                 425                 430         
Gly Leu Ser Lys Gln Gly Ser Ile Asp Leu Pro Thr Pro Tyr Thr Tyr 
        435                 440                 445             
Lys Asp Ser Phe His Phe Asp Ile Arg Ala Leu Glu Pro Gly Arg Arg 
    450                 455                 460                 
Arg Ala Pro Gly Pro Val Arg Ser Thr Trp Thr Pro Pro Asp Lys Ser 
465                 470                 475                 480 
Arg Pro Leu Phe Phe His Ser Val Pro Thr Gln Leu Ser Thr Thr Val 
                485                 490                 495     
Glu Cys Val Pro Val Thr Arg Ser Asn Ser Leu Pro Phe Val Glu Gly 
            500                 505                 510         
Ser Arg Thr Trp Leu Glu Pro Arg Glu Pro Arg Asp Pro Trp Ser Arg 
        515                 520                 525             
Thr Gln Lys Pro Leu Ser Pro Arg Pro Gly Pro Ala Arg Leu Gly Cys 
    530                 535                 540                 
Arg Ser Gly Leu Ser Ser Thr Asp Val Pro Ser Gly His Pro Arg Ala 
545                 550                 555                 560 
Leu Val Arg Gln Ala Ala Val Glu Asp Leu Pro Gly Thr Pro Ile Gly 
                565                 570                 575     
Asp Ala Leu Val Pro Ala Glu Asp Thr Asp Ala Lys Arg Thr Ala Ala 
            580                 585                 590         
Arg Glu Ala Met Ala Gly Lys Gly Arg Ala Gly Gly Arg Lys Cys Gly 
        595                 600                 605             
Gln Arg Arg Leu Lys Met Phe Ser Gln Glu Lys Trp Gln Val Tyr Gly 
    610                 615                 620                 
Asp Glu Thr Phe Lys Arg Ile Tyr Gln Lys Met Lys Ala Ser Pro His 
625                 630                 635                 640 
Gly Gly Lys Lys Ala Arg Glu Val Gly Met Gly Ser Gly Ala Glu Leu 
                645                 650                 655     
Gly Phe Pro Leu Gln Lys Glu Ala Ala Gly Ser Ser Gly Thr Val Pro 
            660                 665                 670         
Thr Gln Asp Arg Arg Thr Pro Val His Glu Asp Ile Ser Ala Gly Ala 
        675                 680                 685             
Thr Pro Glu Pro Trp Gly Asn Pro Pro Ala Leu Glu Ala Ser Leu Val 
    690                 695                 700                 
Thr Glu Pro Thr Lys His Gly Glu Thr Val Ala Arg Arg Gly Asp Ser 
705                 710                 715                 720 
Asp Arg Pro Arg Val Glu Glu Ala Val Ser Ser Pro Ala Leu Gly Gly 
                725                 730                 735     
Arg Asp Ser Pro Cys Ser Gly Ser Arg Ser Pro Leu Val Ser Pro Asn 
            740                 745                 750         
Gly Arg Leu Glu Leu Gly Trp Gln Met Pro Pro Ala Pro Gly Pro Leu 
        755                 760                 765             
Lys Gly Gly Asp Val Glu Ala Pro Arg Pro Val Trp Pro Asp Pro Lys 
    770                 775                 780                 
Leu Glu Gly Gly Ala Arg Gly Val Gly Asp Val Gln Glu Thr Cys Leu 
785                 790                 795                 800 
Trp Ala Gln Thr Val Leu Arg Trp Pro Ser Arg Gly Ser Gly Glu Asp 
                805                 810                 815     
Lys Leu Pro Ser Glu Arg Lys Lys Leu Lys Val Glu Asp Leu His Ser 
            820                 825                 830         
Trp Lys Gln Pro Glu Pro Val Ser Ala Glu Thr Pro Gly Gly Pro Thr 
        835                 840                 845             
Gln Pro Ala Ser Leu Ser Ser Gln Lys Gln Asp Ala Asp Pro Gly Glu 
    850                 855                 860                 
Val Pro Gly Gly Ser Lys Glu Ser Ala Arg Gln Val Gly Glu Pro Leu 
865                 870                 875                 880 
Glu Ser Ser Gly Ala Ser Leu Ala Ala Ala Ser Val Ala Leu Lys Arg 
                885                 890                 895     
Val Gly Pro Arg Asp Lys Ala Thr Pro Leu His Pro Ala Ala Pro Ala 
            900                 905                 910         
Pro Ala Glu His Pro Ser Leu Ala Thr Pro Pro Gln Ala Pro Arg Val 
        915                 920                 925             
Leu Ser Ala Leu Ala Asp Asn Ala Phe Ser Pro Lys Tyr Leu Leu Arg 
    930                 935                 940                 
Leu Pro Gln Ala Glu Thr Pro Leu Pro Leu Pro Ile Pro Trp Gly Pro 
945                 950                 955                 960 
Arg His Ser Gln Asp Ser Leu Cys Ser Ser Gly Trp Pro Glu Glu Arg 
                965                 970                 975     
Ala Ser Phe Val Gly Ser Gly Leu Gly Thr Pro Leu Ser Pro Ser Pro 
            980                 985                 990         
Ala Ser Gly Pro Ser Pro Gly Glu Ala Asp Ser Ile Leu Glu Asp Pro 
        995                 1000                1005            
Ser Cys Ser Arg Pro Gln Asp Gly Arg Lys Gly Ala Gln Leu Gly Gly 
    1010                1015                1020                
Asp Lys Gly Asp Arg Met Ala Thr Ser Arg Pro Ala Ala Arg Glu Leu 
1025                1030                1035                1040
Pro Ile Ser Ala Pro Gly Ala Pro Arg Glu Ala Thr Ser Ser Pro Pro 
                1045                1050                1055    
Thr Pro Thr Cys Glu Ala His Leu Val Gln Asp Met Glu Gly Asp Ser 
            1060                1065                1070        
His Arg Ile His Arg Leu Cys Met Gly Ser Thr Leu Ala Arg Ala Arg 
        1075                1080                1085            
Leu Ser Gly Asp Val Leu Asn Pro Trp Val Pro Asn Trp Glu Leu Gly 
    1090                1095                1100                
Glu Pro Pro Gly Asn Ala Pro Glu Asp Pro Ser Ser Gly Pro Leu Val 
1105                1110                1115                1120
Gly Pro Asp Pro Cys Ser Pro Leu Gln Pro Gly Ser Phe Leu Thr Ala 
                1125                1130                1135    
Leu Thr Arg Pro Gln Gly Val Pro Pro Gly Trp Pro Glu Leu Ala Leu 
            1140                1145                1150        
Ser Ser His Ser Gly Thr Ser Arg Ser His Ser Thr Arg Ser Pro His 
        1155                1160                1165            
Ser Thr Gln Asn Pro Phe Pro Ser Leu Lys Ala Glu Pro Arg Leu Thr 
    1170                1175                1180                
Trp Cys Cys Leu Ser Arg Ser Val Pro Leu Pro Ala Glu Gln Lys Ala 
1185                1190                1195                1200
Lys Ala Ala Ser Val Tyr Leu Ala Val His Phe Pro Gly Ser Ser Leu 
                1205                1210                1215    
Arg Asp Glu Gly Pro Asn Gly Pro Pro Gly Ser Asn Gly Gly Trp Thr 
            1220                1225                1230        
Trp Thr Ser Pro Gly Glu Gly Gly Pro Ala Gln Met Ser Lys Phe Ser 
        1235                1240                1245            
Tyr Pro Thr Val Pro Gly Val Met Pro Gln His Gln Val Ser Glu Pro 
    1250                1255                1260                
Glu Trp Lys Lys Gly Leu Pro Trp Arg Ala Lys Met Ser Arg Gly Asn 
1265                1270                1275                1280
Ser Lys Gln Arg Lys Leu Lys Ile Asn Pro Lys Arg Tyr Lys Gly Asn 
                1285                1290                1295    
Phe Leu Gln Ser Cys Val Gln Leu Arg Ala Ser Arg Leu Arg Thr Pro 
            1300                1305                1310        
Thr Trp Val Arg Arg Arg Ser Arg His Pro Pro Ala Leu Glu Gly Leu 
        1315                1320                1325            
Lys Pro Cys Arg Thr Pro Gly Gln Thr Ser Ser Glu Ile Ala Gly Leu 
    1330                1335                1340                
Asn Leu Gln Glu Glu Pro Ser Cys Ala Thr Ser Glu Ser Pro Pro Cys 
1345                1350                1355                1360
Cys Gly Lys Glu Glu Lys Lys Glu Gly Asp Cys Arg Gln Thr Leu Gly 
                1365                1370                1375    
Thr Leu Ser Leu Gly Thr Ser Ser Arg Ile Val Arg Glu Met Asp Lys 
            1380                1385                1390        
Arg Thr Val Lys Asp Ile Ser Pro Ser Ala Gly Glu His Gly Asp Cys 
        1395                1400                1405            
Thr Thr His Ser Thr Ala Ala Thr Ser Gly Leu Ser Leu Gln Ser Asp 
    1410                1415                1420                
Thr Cys Leu Ala Val Val Asn Asp Val Pro Leu Pro Pro Gly Lys Gly 
1425                1430                1435                1440
Leu Asp Leu Gly Leu Leu Glu Thr Gln Leu Leu Ala Ser Gln Asp Ser 
                1445                1450                1455    
Val Ser Thr Asp Pro Lys Pro Tyr Ile Phe Ser Asp Ala Gln Arg Pro 
            1460                1465                1470        
Ser Ser Phe Gly Ser Lys Gly Thr Phe Pro His His Asp Ile Ala Thr 
        1475                1480                1485            
Ser Val Ala Ala Val Cys Ile Ser Leu Pro Val Arg Thr Asp His Ile 
    1490                1495                1500                
Ala Gln Glu Ile His Ser Ala Glu Ser Arg Asp His Ser Gln Thr Ala 
1505                1510                1515                1520
Gly Arg Thr Leu Thr Ser Ser Ser Pro Asp Ser Lys Val Thr Glu Glu 
                1525                1530                1535    
Gly Arg Ala Gln Thr Leu Leu Pro Gly Arg Pro Ser Ser Gly Gln Arg 
            1540                1545                1550        
Ile Ser Asp Ser Val Pro Leu Glu Ser Thr Glu Lys Thr His Leu Glu 
        1555                1560                1565            
Ile Pro Ala Ser Gly Pro Ser Ser Ala Ser Ser His His Lys Glu Gly 
    1570                1575                1580                
Arg His Lys Thr Phe Phe Pro Ser Arg Gly Gln Tyr Gly Cys Gly Glu 
1585                1590                1595                1600
Met Thr Val Pro Cys Pro Ser Leu Gly Ser Asp Gly Arg Lys Arg Gln 
                1605                1610                1615    
Val Ser Gly Leu Ile Thr Arg Lys Asp Ser Val Val Pro Ser Lys Pro 
            1620                1625                1630        
Glu Gln Pro Ile Glu Ile Pro Glu Ala Pro Ser Lys Ser Leu Lys Lys 
        1635                1640                1645            
Arg Ser Leu Glu Gly Met Arg Lys Gln Thr Arg Val Glu Phe Ser Asp 
    1650                1655                1660                
Thr Ser Ser Asp Asp Glu Asp Arg Leu Val Ile Glu Ile 
1665                1670                1675        

<210> 120
<211> 1193
<212> PRT
<213> human

<400> 120
Met Trp Arg Val Lys Lys Leu Ser Leu Ser Leu Ser Pro Ser Pro Gln 
1               5                   10                  15      
Thr Gly Lys Pro Ser Met Arg Thr Pro Leu Arg Glu Leu Thr Leu Gln 
            20                  25                  30          
Pro Gly Ala Leu Thr Asn Ser Gly Lys Arg Ser Pro Ala Cys Ser Ser 
        35                  40                  45              
Leu Thr Pro Ser Leu Cys Lys Leu Gly Leu Gln Glu Gly Ser Asn Asn 
    50                  55                  60                  
Ser Ser Pro Val Asp Phe Val Asn Asn Lys Arg Thr Asp Leu Ser Ser 
65                  70                  75                  80  
Glu His Phe Ser His Ser Ser Lys Trp Leu Glu Thr Cys Gln His Glu 
                85                  90                  95      
Ser Asp Glu Gln Pro Leu Asp Pro Ile Pro Gln Ile Ser Ser Thr Pro 
            100                 105                 110         
Lys Thr Ser Glu Glu Ala Val Asp Pro Leu Gly Asn Tyr Met Val Lys 
        115                 120                 125             
Thr Ile Val Leu Val Pro Ser Pro Leu Gly Gln Gln Gln Asp Met Ile 
    130                 135                 140                 
Phe Glu Ala Arg Leu Asp Thr Met Ala Glu Thr Asn Ser Ile Ser Leu 
145                 150                 155                 160 
Asn Gly Pro Leu Arg Thr Asp Asp Leu Val Arg Glu Glu Val Ala Pro 
                165                 170                 175     
Cys Met Gly Asp Arg Phe Ser Glu Val Ala Ala Val Ser Glu Lys Pro 
            180                 185                 190         
Ile Phe Gln Glu Ser Pro Ser His Leu Leu Glu Glu Ser Pro Pro Asn 
        195                 200                 205             
Pro Cys Ser Glu Gln Leu His Cys Ser Lys Glu Ser Leu Ser Ser Arg 
    210                 215                 220                 
Thr Glu Ala Val Arg Glu Asp Leu Val Pro Ser Glu Ser Asn Ala Phe 
225                 230                 235                 240 
Leu Pro Ser Ser Val Leu Trp Leu Ser Pro Ser Thr Ala Leu Ala Ala 
                245                 250                 255     
Asp Phe Arg Val Asn His Val Asp Pro Glu Glu Glu Ile Val Glu His 
            260                 265                 270         
Gly Ala Met Glu Glu Arg Glu Met Arg Phe Pro Thr His Pro Lys Glu 
        275                 280                 285             
Ser Glu Thr Glu Asp Gln Ala Leu Val Ser Ser Val Glu Asp Ile Leu 
    290                 295                 300                 
Ser Thr Cys Leu Thr Pro Asn Leu Val Glu Met Glu Ser Gln Glu Ala 
305                 310                 315                 320 
Pro Gly Pro Ala Val Glu Asp Val Gly Arg Ile Leu Gly Ser Asp Thr 
                325                 330                 335     
Glu Ser Trp Met Ser Pro Leu Ala Trp Leu Glu Lys Gly Val Asn Thr 
            340                 345                 350         
Ser Val Met Leu Glu Asn Leu Arg Gln Ser Leu Ser Leu Pro Ser Met 
        355                 360                 365             
Leu Arg Asp Ala Ala Ile Gly Thr Thr Pro Phe Ser Thr Cys Ser Val 
    370                 375                 380                 
Gly Thr Trp Phe Thr Pro Ser Ala Pro Gln Glu Lys Ser Thr Asn Thr 
385                 390                 395                 400 
Ser Gln Thr Gly Leu Val Gly Thr Lys His Ser Thr Ser Glu Thr Glu 
                405                 410                 415     
Gln Leu Leu Cys Gly Arg Pro Pro Asp Leu Thr Ala Leu Ser Arg His 
            420                 425                 430         
Asp Leu Glu Asp Asn Leu Leu Ser Ser Leu Val Ile Leu Glu Val Leu 
        435                 440                 445             
Ser Arg Gln Leu Arg Asp Trp Lys Ser Gln Leu Ala Val Pro His Pro 
    450                 455                 460                 
Glu Thr Gln Asp Ser Ser Thr Gln Thr Asp Thr Ser His Ser Gly Ile 
465                 470                 475                 480 
Thr Asn Lys Leu Gln His Leu Lys Glu Ser His Glu Met Gly Gln Ala 
                485                 490                 495     
Leu Gln Gln Ala Arg Asn Val Met Gln Ser Trp Val Leu Ile Ser Lys 
            500                 505                 510         
Glu Leu Ile Ser Leu Leu His Leu Ser Leu Leu His Leu Glu Glu Asp 
        515                 520                 525             
Lys Thr Thr Val Ser Gln Glu Ser Arg Arg Ala Glu Thr Leu Val Cys 
    530                 535                 540                 
Cys Cys Phe Asp Leu Leu Lys Lys Leu Arg Ala Lys Leu Gln Ser Leu 
545                 550                 555                 560 
Lys Ala Glu Arg Glu Glu Ala Arg His Arg Glu Glu Met Ala Leu Arg 
                565                 570                 575     
Gly Lys Asp Ala Ala Glu Ile Val Leu Glu Ala Phe Cys Ala His Ala 
            580                 585                 590         
Ser Gln Arg Ile Ser Gln Leu Glu Gln Asp Leu Ala Ser Met Arg Glu 
        595                 600                 605             
Phe Arg Gly Leu Leu Lys Asp Ala Gln Thr Gln Leu Val Gly Leu His 
    610                 615                 620                 
Ala Lys Gln Glu Glu Leu Val Gln Gln Thr Val Ser Leu Thr Ser Thr 
625                 630                 635                 640 
Leu Gln Gln Asp Trp Arg Ser Met Gln Leu Asp Tyr Thr Thr Trp Thr 
                645                 650                 655     
Ala Leu Leu Ser Arg Ser Arg Gln Leu Thr Glu Lys Leu Thr Val Lys 
            660                 665                 670         
Ser Gln Gln Ala Leu Gln Glu Arg Asp Val Ala Ile Glu Glu Lys Gln 
        675                 680                 685             
Glu Val Ser Arg Val Leu Glu Gln Val Ser Ala Gln Leu Glu Glu Cys 
    690                 695                 700                 
Lys Gly Gln Thr Glu Gln Leu Glu Leu Glu Asn Ser Arg Leu Ala Thr 
705                 710                 715                 720 
Asp Leu Arg Ala Gln Leu Gln Ile Leu Ala Asn Met Asp Ser Gln Leu 
                725                 730                 735     
Lys Glu Leu Gln Ser Gln His Thr His Cys Ala Gln Asp Leu Ala Met 
            740                 745                 750         
Lys Asp Glu Leu Leu Cys Gln Leu Thr Gln Ser Asn Glu Glu Gln Ala 
        755                 760                 765             
Ala Gln Trp Gln Lys Glu Glu Met Ala Leu Lys His Met Gln Ala Glu 
    770                 775                 780                 
Leu Gln Gln Gln Gln Ala Val Leu Ala Lys Glu Val Arg Asp Leu Lys 
785                 790                 795                 800 
Glu Thr Leu Glu Phe Ala Asp Gln Glu Asn Gln Val Ala His Leu Glu 
                805                 810                 815     
Leu Gly Gln Val Glu Cys Gln Leu Lys Thr Thr Leu Glu Val Leu Arg 
            820                 825                 830         
Glu Arg Ser Leu Gln Cys Glu Asn Leu Lys Asp Thr Val Glu Asn Leu 
        835                 840                 845             
Thr Ala Lys Leu Ala Ser Thr Ile Ala Asp Asn Gln Glu Gln Asp Leu 
    850                 855                 860                 
Glu Lys Thr Arg Gln Tyr Ser Gln Lys Leu Gly Leu Leu Thr Glu Gln 
865                 870                 875                 880 
Leu Gln Ser Leu Thr Leu Phe Leu Gln Thr Lys Leu Lys Glu Lys Thr 
                885                 890                 895     
Glu Gln Glu Thr Leu Leu Leu Ser Thr Ala Cys Pro Pro Thr Gln Glu 
            900                 905                 910         
His Pro Leu Pro Asn Asp Arg Thr Phe Leu Gly Ser Ile Leu Thr Ala 
        915                 920                 925             
Val Ala Asp Glu Glu Pro Glu Ser Thr Pro Val Pro Leu Leu Gly Ser 
    930                 935                 940                 
Asp Lys Ser Ala Phe Thr Arg Val Ala Ser Met Val Ser Leu Gln Pro 
945                 950                 955                 960 
Ala Glu Thr Pro Gly Met Glu Glu Ser Leu Ala Glu Met Ser Ile Met 
                965                 970                 975     
Thr Thr Glu Leu Gln Ser Leu Cys Ser Leu Leu Gln Glu Ser Lys Glu 
            980                 985                 990         
Glu Ala Ile Arg Thr Leu Gln Arg Lys Ile Cys Glu Leu Gln Ala Arg 
        995                 1000                1005            
Leu Gln Ala Gln Glu Glu Gln His Gln Glu Val Gln Lys Ala Lys Glu 
    1010                1015                1020                
Ala Asp Ile Glu Lys Leu Asn Gln Ala Leu Cys Leu Arg Tyr Lys Asn 
1025                1030                1035                1040
Glu Lys Glu Leu Gln Glu Val Ile Gln Gln Gln Asn Glu Lys Ile Leu 
                1045                1050                1055    
Glu Gln Ile Asp Lys Ser Gly Glu Leu Ile Ser Leu Arg Glu Glu Val 
            1060                1065                1070        
Thr His Leu Thr Arg Ser Leu Arg Arg Ala Glu Thr Glu Thr Lys Val 
        1075                1080                1085            
Leu Gln Glu Ala Leu Ala Gly Gln Leu Asp Ser Asn Cys Gln Pro Met 
    1090                1095                1100                
Ala Thr Asn Trp Ile Gln Glu Lys Val Trp Leu Ser Gln Glu Val Asp 
1105                1110                1115                1120
Lys Leu Arg Val Met Phe Leu Glu Met Lys Asn Glu Lys Glu Lys Leu 
                1125                1130                1135    
Met Ile Lys Phe Gln Ser His Arg Asn Ile Leu Glu Glu Asn Leu Arg 
            1140                1145                1150        
Arg Ser Asp Lys Glu Leu Glu Lys Leu Asp Asp Ile Val Gln His Ile 
        1155                1160                1165            
Tyr Lys Thr Leu Leu Ser Ile Pro Glu Val Val Arg Gly Cys Lys Glu 
    1170                1175                1180                
Leu Gln Gly Leu Leu Glu Phe Leu Ser 
1185                1190            

<210> 121
<211> 96
<212> PRT
<213> human

<400> 121
Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      
Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Pro Ser 
            20                  25                  30          
Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu Glu 
        35                  40                  45              
Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  
Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  
Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Ala Val Leu Phe Glu Lys 
                85                  90                  95      



<210> 122
<211> 1265
<212> PRT
<213> human

<400> 122
Met Lys Val Arg Leu Leu Arg Gln Leu Ser Ala Ala Ala Lys Val Lys 
1               5                   10                  15      
Ala Pro Ser Gly Leu Gln Gly Pro Pro Gln Ala His Gln Phe Ile Ser 
            20                  25                  30          
Leu Leu Leu Glu Glu Tyr Gly Ala Leu Cys Gln Ala Ala Arg Ser Ile 
        35                  40                  45              
Ser Thr Phe Leu Gly Thr Leu Glu Asn Glu His Leu Lys Lys Phe Gln 
    50                  55                  60                  
Val Thr Trp Glu Leu His Asn Lys His Leu Phe Glu Asn Leu Val Phe 
65                  70                  75                  80  
Ser Glu Pro Leu Leu Gln Ser Asn Leu Pro Ala Leu Val Ser Gln Ile 
                85                  90                  95      
Arg Leu Gly Thr Thr Thr His Asp Thr Cys Ser Glu Asp Thr Tyr Ser 
            100                 105                 110         
Thr Leu Leu Gln Arg Tyr Gln Arg Ser Glu Glu Glu Leu Arg Arg Val 
        115                 120                 125             
Ala Glu Glu Trp Leu Glu Cys Gln Lys Arg Ile Asp Ala Tyr Val Asp 
    130                 135                 140                 
Glu Gln Met Thr Met Lys Thr Lys Gln Arg Met Leu Thr Glu Asp Trp 
145                 150                 155                 160 
Glu Leu Phe Lys Gln Arg Arg Phe Ile Glu Glu Gln Leu Thr Asn Lys 
                165                 170                 175     
Lys Ala Val Thr Gly Glu Asn Asn Phe Thr Asp Thr Met Arg His Met 
            180                 185                 190         
Leu Ser Ser Arg Leu Ser Met Pro Asp Cys Pro Asn Cys Asn Tyr Arg 
        195                 200                 205             
Arg Arg Cys Ala Cys Asp Asp Cys Ser Leu Ser His Ile Leu Thr Cys 
    210                 215                 220                 
Gly Ile Met Asp Pro Pro Val Thr Asp Asp Ile His Ile His Gln Leu 
225                 230                 235                 240 
Pro Leu Gln Val Asp Pro Ala Pro Asp Tyr Leu Ala Glu Arg Ser Pro 
                245                 250                 255     
Pro Ser Val Ser Ser Ala Ser Ser Gly Ser Gly Ser Ser Ser Pro Ile 
            260                 265                 270         
Thr Ile Gln Gln His Pro Arg Leu Ile Leu Thr Asp Ser Gly Ser Ala 
        275                 280                 285             
Pro Thr Phe Cys Ser Asp Asp Glu Asp Val Ala Pro Leu Ser Ala Lys 
    290                 295                 300                 
Phe Ala Asp Ile Tyr Pro Leu Ser Asn Tyr Asp Asp Thr Glu Val Val 
305                 310                 315                 320 
Ala Asn Met Asn Gly Ile His Ser Glu Leu Asn Gly Gly Gly Glu Asn 
                325                 330                 335     
Met Ala Leu Lys Asp Glu Ser Pro Gln Ile Ser Ser Thr Ser Ser Ser 
            340                 345                 350         
Ser Ser Glu Ala Asp Asp Glu Glu Ala Asp Gly Glu Ser Ser Gly Glu 
        355                 360                 365             
Pro Pro Gly Ala Pro Lys Glu Asp Gly Val Leu Gly Ser Arg Ser Pro 
    370                 375                 380                 
Arg Thr Glu Glu Ser Lys Ala Asp Ser Pro Pro Pro Ser Tyr Pro Thr 
385                 390                 395                 400 
Gln Gln Ala Glu Gln Ala Pro Asn Thr Cys Glu Cys His Val Cys Lys 
                405                 410                 415     
Gln Glu Ala Ser Gly Leu Thr Pro Ser Ala Met Thr Ala Gly Ala Leu 
            420                 425                 430         
Pro Pro Gly His Gln Phe Leu Ser Pro Glu Lys Pro Thr His Pro Ala 
        435                 440                 445             
Leu His Leu Tyr Pro His Ile His Gly His Val Pro Leu His Thr Val 
    450                 455                 460                 
Pro His Leu Pro Arg Pro Leu Ile His Pro Thr Leu Tyr Ala Thr Pro 
465                 470                 475                 480 
Pro Phe Thr His Ser Lys Ala Leu Pro Pro Ala Pro Val Gln Asn His 
                485                 490                 495     
Thr Asn Lys His Gln Val Phe Asn Ala Ser Leu Gln Asp His Ile Tyr 
            500                 505                 510         
Pro Ser Cys Phe Gly Asn Thr Pro Glu Trp Asn Ser Ser Lys Phe Ile 
        515                 520                 525             
Ser Leu Trp Gly Ser Glu Val Met Asn Asp Lys Asn Trp Asn Pro Gly 
    530                 535                 540                 
Thr Phe Leu Pro Asp Thr Ile Ser Gly Ser Glu Ile Leu Gly Pro Thr 
545                 550                 555                 560 
Leu Ser Glu Thr Arg Pro Glu Ala Leu Pro Pro Pro Ser Ser Asn Glu 
                565                 570                 575     
Thr Pro Ala Val Ser Asp Ser Lys Glu Lys Lys Asn Ala Ala Lys Lys 
            580                 585                 590         
Lys Cys Leu Tyr Asn Phe Gln Asp Ala Phe Met Glu Ala Asn Lys Val 
        595                 600                 605             
Val Met Ala Thr Ser Ser Ala Thr Ser Ser Val Ser Cys Thr Ala Thr 
    610                 615                 620                 
Thr Val Gln Ser Ser Asn Ser Gln Phe Arg Val Ser Ser Lys Arg Pro 
625                 630                 635                 640 
Pro Ser Val Gly Asp Val Phe His Gly Ile Ser Lys Glu Asp His Arg 
                645                 650                 655     
His Ser Ala Pro Ala Ala Pro Arg Asn Ser Pro Thr Gly Leu Ala Pro 
            660                 665                 670         
Leu Pro Ala Leu Ser Pro Ala Ala Leu Ser Pro Ala Ala Leu Ser Pro 
        675                 680                 685             
Ala Ser Thr Pro His Leu Ala Asn Leu Ala Ala Pro Ser Phe Pro Lys 
    690                 695                 700                 
Thr Ala Thr Thr Thr Pro Gly Phe Val Asp Thr Arg Lys Ser Phe Cys 
705                 710                 715                 720 
Pro Ala Pro Leu Pro Pro Ala Thr Asp Gly Ser Ile Ser Ala Pro Pro 
                725                 730                 735     
Ser Val Cys Ser Asp Pro Asp Cys Glu Gly His Arg Cys Glu Asn Gly 
            740                 745                 750         
Val Tyr Asp Pro Gln Gln Asp Asp Gly Asp Glu Ser Ala Asp Glu Asp 
        755                 760                 765             
Ser Cys Ser Glu His Ser Ser Ser Thr Ser Thr Ser Thr Asn Gln Lys 
    770                 775                 780                 
Glu Gly Lys Tyr Cys Asp Cys Cys Tyr Cys Glu Phe Phe Gly His Gly 
785                 790                 795                 800 
Gly Pro Pro Ala Ala Pro Thr Ser Arg Asn Tyr Ala Glu Met Arg Glu 
                805                 810                 815     
Lys Leu Arg Leu Arg Leu Thr Lys Arg Lys Glu Glu Gln Pro Lys Lys 
            820                 825                 830         
Met Asp Gln Ile Ser Glu Arg Glu Ser Val Val Asp His Arg Arg Val 
        835                 840                 845             
Glu Asp Leu Leu Gln Phe Ile Asn Ser Ser Glu Thr Lys Pro Val Ser 
    850                 855                 860                 
Ser Thr Arg Ala Ala Lys Arg Ala Arg His Lys Gln Arg Lys Leu Glu 
865                 870                 875                 880 
Glu Lys Ala Arg Leu Glu Ala Glu Ala Arg Ala Arg Glu His Leu His 
                885                 890                 895     
Leu Gln Glu Glu Gln Arg Arg Arg Glu Glu Glu Glu Asp Glu Glu Glu 
            900                 905                 910         
Glu Glu Asp Arg Phe Lys Glu Glu Phe Gln Arg Leu Gln Glu Leu Gln 
        915                 920                 925             
Lys Leu Arg Ala Val Lys Lys Lys Lys Lys Glu Arg Pro Ser Lys Asp 
    930                 935                 940                 
Cys Pro Lys Leu Asp Met Leu Thr Arg Asn Phe Gln Ala Ala Thr Glu 
945                 950                 955                 960 
Ser Val Pro Asn Ser Gly Asn Ile His Asn Gly Ser Leu Glu Gln Thr 
                965                 970                 975     
Glu Glu Pro Glu Thr Ser Ser His Ser Pro Ser Arg His Met Asn His 
            980                 985                 990         
Ser Glu Pro Arg Pro Gly Leu Gly Ala Asp Gly Asp Ala Ala Asp Pro 
        995                 1000                1005            
Val Asp Thr Arg Asp Ser Lys Phe Leu Leu Pro Lys Glu Val Asn Gly 
    1010                1015                1020                
Lys Gln His Glu Pro Leu Ser Phe Phe Phe Asp Ile Met Gln His His 
1025                1030                1035                1040
Lys Glu Gly Asn Gly Lys Gln Lys Leu Arg Gln Thr Ser Lys Ala Ser 
                1045                1050                1055    
Ser Glu Pro Ala Arg Arg Pro Thr Glu Pro Pro Lys Ala Thr Glu Gly 
            1060                1065                1070        
Gln Ser Lys Pro Arg Ala Gln Thr Glu Ser Lys Ala Lys Val Val Asp 
        1075                1080                1085            
Leu Met Ser Ile Thr Glu Gln Lys Arg Glu Glu Arg Lys Val Asn Ser 
    1090                1095                1100                
Asn Asn Asn Asn Lys Lys Gln Leu Asn His Ile Lys Asp Glu Lys Ser 
1105                1110                1115                1120
Asn Pro Thr Pro Met Glu Pro Thr Ser Pro Gly Glu His Gln Gln Asn 
                1125                1130                1135    
Ser Lys Leu Val Leu Ala Glu Ser Pro Gln Pro Lys Gly Lys Asn Lys 
            1140                1145                1150        
Lys Asn Lys Lys Lys Lys Gly Asp Arg Val Asn Asn Ser Ile Asp Gly 
        1155                1160                1165            
Val Ser Leu Leu Leu Pro Ser Leu Gly Tyr Asn Gly Ala Ile Leu Ala 
    1170                1175                1180                
His Cys Asn Leu Arg Leu Pro Gly Ser Ser Asp Cys Ala Ala Ser Ala 
1185                1190                1195                1200
Ser Gln Val Val Gly Ile Thr Asp Asp Val Phe Leu Pro Lys Asp Ile 
                1205                1210                1215    
Asp Leu Asp Ser Val Asp Met Asp Glu Thr Glu Arg Glu Val Glu Tyr 
            1220                1225                1230        
Phe Lys Arg Phe Cys Leu Asp Ser Ala Arg Gln Thr Arg Gln Arg Leu 
        1235                1240                1245            
Ser Ile Asn Trp Ser Asn Phe Ser Leu Lys Lys Ala Thr Phe Ala Ala 
    1250                1255                1260                
His 
1265

<210> 123
<211> 259
<212> PRT
<213> human

<400> 123
Met Lys Asp Val Asp Asn Leu Lys Ser Ile Lys Glu Glu Trp Val Cys 
1               5                   10                  15      
Glu Thr Gly Ser Asp Asn Gln Pro Leu Gly Asn Asn Gln Gln Ser Asn 
            20                  25                  30          
Cys Glu Tyr Phe Val Asp Ser Leu Phe Glu Glu Ala Gln Lys Val Ser 
        35                  40                  45              
Ser Lys Cys Val Ser Pro Ala Glu Gln Lys Lys Gln Val Asp Val Asn 
    50                  55                  60                  
Ile Lys Leu Trp Lys Asn Gly Phe Thr Val Asn Asp Asp Phe Arg Ser 
65                  70                  75                  80  
Tyr Ser Asp Gly Ala Ser Gln Gln Phe Leu Asn Ser Ile Lys Lys Gly 
                85                  90                  95      
Glu Leu Pro Ser Glu Leu Gln Gly Ile Phe Asp Lys Glu Glu Val Asp 
            100                 105                 110         
Val Lys Val Glu Asp Lys Lys Asn Glu Ile Cys Leu Ser Thr Lys Pro 
        115                 120                 125             
Val Phe Gln Pro Phe Ser Gly Gln Gly His Arg Leu Gly Ser Ala Thr 
    130                 135                 140                 
Pro Lys Ile Val Ser Lys Ala Lys Asn Ile Glu Val Glu Asn Lys Asn 
145                 150                 155                 160 
Asn Leu Ser Ala Val Pro Leu Asn Asn Leu Glu Pro Ile Thr Asn Ile 
                165                 170                 175     
Gln Ile Trp Leu Ala Asn Gly Lys Arg Ile Val Gln Lys Phe Asn Ile 
            180                 185                 190         
Thr His Arg Val Ser His Ile Lys Asp Phe Ile Glu Lys Tyr Gln Gly 
        195                 200                 205             
Ser Gln Arg Ser Pro Pro Phe Ser Leu Ala Thr Ala Leu Pro Val Leu 
    210                 215                 220                 
Arg Leu Leu Asp Glu Thr Leu Thr Leu Glu Glu Ala Asp Leu Gln Asn 
225                 230                 235                 240 
Ala Val Ile Ile Gln Arg Leu Gln Lys Thr Ala Ser Phe Arg Glu Leu 
                245                 250                 255     
Ser Glu His 
            

<210> 124
<211> 560
<212> PRT
<213> human

<400> 124
Met Leu Arg Gly Thr Leu Leu Cys Ala Val Leu Gly Leu Leu Arg Ala 
1               5                   10                  15      
Gln Pro Phe Pro Cys Pro Pro Ala Cys Lys Cys Val Phe Arg Asp Ala 
            20                  25                  30          
Ala Gln Cys Ser Gly Gly Asp Val Ala Arg Ile Ser Ala Leu Gly Leu 
        35                  40                  45              
Pro Thr Asn Leu Thr His Ile Leu Leu Phe Gly Met Gly Arg Gly Val 
    50                  55                  60                  
Leu Gln Ser Gln Ser Phe Ser Gly Met Thr Val Leu Gln Arg Leu Met 
65                  70                  75                  80  
Ile Ser Asp Ser His Ile Ser Ala Val Ala Pro Gly Thr Phe Ser Asp 
                85                  90                  95      
Leu Ile Lys Leu Lys Thr Leu Arg Leu Ser Arg Asn Lys Ile Thr His 
            100                 105                 110         
Leu Pro Gly Ala Leu Leu Asp Lys Met Val Leu Leu Glu Gln Leu Phe 
        115                 120                 125             
Leu Asp His Asn Ala Leu Arg Gly Ile Asp Gln Asn Met Phe Gln Lys 
    130                 135                 140                 
Leu Val Asn Leu Gln Glu Leu Ala Leu Asn Gln Asn Gln Leu Asp Phe 
145                 150                 155                 160 
Leu Pro Ala Ser Leu Phe Thr Asn Leu Glu Asn Leu Lys Leu Leu Asp 
                165                 170                 175     
Leu Ser Gly Asn Asn Leu Thr His Leu Pro Lys Gly Leu Leu Gly Ala 
            180                 185                 190         
Gln Ala Lys Leu Glu Arg Leu Leu Leu His Ser Asn Arg Leu Val Ser 
        195                 200                 205             
Leu Asp Ser Gly Leu Leu Asn Ser Leu Gly Ala Leu Thr Glu Leu Gln 
    210                 215                 220                 
Phe His Arg Asn His Ile Arg Ser Ile Ala Pro Gly Ala Phe Asp Arg 
225                 230                 235                 240 
Leu Pro Asn Leu Ser Ser Leu Thr Leu Ser Arg Asn His Leu Ala Phe 
                245                 250                 255     
Leu Pro Ser Ala Leu Phe Leu His Ser His Asn Leu Thr Leu Leu Thr 
            260                 265                 270         
Leu Phe Glu Asn Pro Leu Ala Glu Leu Pro Gly Val Leu Phe Gly Glu 
        275                 280                 285             
Met Gly Gly Leu Gln Glu Leu Trp Leu Asn Arg Thr Gln Leu Arg Thr 
    290                 295                 300                 
Leu Pro Ala Ala Ala Phe Arg Asn Leu Ser Arg Leu Arg Tyr Leu Gly 
305                 310                 315                 320 
Val Thr Leu Ser Pro Arg Leu Ser Ala Leu Pro Gln Gly Ala Phe Gln 
                325                 330                 335     
Gly Leu Gly Glu Leu Gln Val Leu Ala Leu His Ser Asn Gly Leu Thr 
            340                 345                 350         
Ala Leu Pro Asp Gly Leu Leu Arg Gly Leu Gly Lys Leu Arg Gln Val 
        355                 360                 365             
Ser Leu Arg Arg Asn Arg Leu Arg Ala Leu Pro Arg Ala Leu Phe Arg 
    370                 375                 380                 
Asn Leu Ser Ser Leu Glu Ser Val Gln Leu Asp His Asn Gln Leu Glu 
385                 390                 395                 400 
Thr Leu Pro Gly Asp Val Phe Gly Ala Leu Pro Arg Leu Thr Glu Val 
                405                 410                 415     
Leu Leu Gly His Asn Ser Trp Arg Cys Asp Cys Gly Leu Gly Pro Phe 
            420                 425                 430         
Leu Gly Trp Leu Arg Gln His Leu Gly Leu Val Gly Gly Glu Glu Pro 
        435                 440                 445             
Pro Arg Cys Ala Gly Pro Gly Ala His Ala Gly Leu Pro Leu Trp Ala 
    450                 455                 460                 
Leu Pro Gly Gly Asp Ala Glu Cys Pro Gly Pro Arg Gly Pro Pro Pro 
465                 470                 475                 480 
Arg Pro Ala Ala Asp Ser Ser Ser Glu Ala Pro Val His Pro Ala Leu 
                485                 490                 495     
Ala Pro Asn Ser Ser Glu Pro Trp Val Trp Ala Gln Pro Val Thr Thr 
            500                 505                 510         
Gly Lys Gly Gln Asp His Ser Pro Phe Trp Gly Phe Tyr Phe Leu Leu 
        515                 520                 525             
Leu Ala Val Gln Ala Met Ile Thr Val Ile Ile Val Phe Ala Met Ile 
    530                 535                 540                 
Lys Ile Gly Gln Leu Phe Arg Lys Leu Ile Arg Glu Arg Ala Leu Gly 
545                 550                 555                 560 



<210> 125
<211> 1941
<212> PRT
<213> human

<400> 125
Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu 
1               5                   10                  15      
Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His 
            20                  25                  30          
Leu Lys Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu 
        35                  40                  45              
Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys 
    50                  55                  60                  
Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met 
65                  70                  75                  80  
Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg 
                85                  90                  95      
Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala 
            100                 105                 110         
Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asn Pro Asn Ile Thr Asp 
        115                 120                 125             
Phe Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr 
    130                 135                 140                 
Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys 
145                 150                 155                 160 
Ser Lys Cys Glu Tyr Gln Pro Leu Leu Phe Ala Val Ser Arg Arg Lys 
                165                 170                 175     
Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Val Asn Ala 
            180                 185                 190         
Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile His Ala Val Thr Leu Gly 
        195                 200                 205             
Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val Leu 
    210                 215                 220                 
Ser Arg Asp Ala Phe Arg Lys Ile Ala Gly Asp Tyr Ala Ile Glu Ala 
225                 230                 235                 240 
Lys Asn Arg Val Ile Phe Asp Leu Ile Tyr Glu Tyr Glu Arg Lys Arg 
                245                 250                 255     
Tyr Glu Asp Leu Pro Ile Asn Ser Asn Pro Val Ser Ser Gln Lys Gln 
            260                 265                 270         
Pro Ala Leu Lys Ala Thr Ser Gly Lys Glu Asp Ser Ile Ser Asn Ile 
        275                 280                 285             
Ala Thr Glu Ile Lys Asp Gly Gln Lys Ser Gly Thr Val Ser Ser Gln 
    290                 295                 300                 
Lys Gln Pro Ala Leu Lys Asp Thr Ser Asp Lys Asp Asp Ser Val Ser 
305                 310                 315                 320 
Asn Thr Ala Thr Glu Ile Lys Asp Glu Gln Lys Ser Gly Thr Val Leu 
                325                 330                 335     
Pro Ala Val Glu Gln Cys Leu Asn Arg Ser Leu Tyr Arg Pro Asp Ala 
            340                 345                 350         
Val Ala Gln Pro Val Thr Glu Asn Glu Phe Ser Leu Glu Ser Glu Ile 
        355                 360                 365             
Ile Ser Lys Leu Tyr Ile Pro Lys Arg Lys Ile Ile Ser Pro Arg Ser 
    370                 375                 380                 
Ile Lys Asp Val Leu Pro Pro Val Glu Glu Ala Val Asp Arg Cys Leu 
385                 390                 395                 400 
Tyr Leu Leu Asp Arg Phe Ala Gln Pro Val Thr Lys Asp Lys Phe Ala 
                405                 410                 415     
Leu Glu Ser Glu Asn Ile Ser Glu Pro Tyr Phe Thr Asn Arg Arg Thr 
            420                 425                 430         
Ile Ser Gln Gln Ser Ala Glu Asn Leu Asp Ala Ala Cys Gly Ile Asp 
        435                 440                 445             
Lys Thr Glu Asn Gly Asn Met Phe Glu Asp Gln Asn Val Asp Lys Glu 
    450                 455                 460                 
Gly Lys Ala Leu Pro Ala Thr Gly Gln Lys Ala Asn Val Ser Pro Glu 
465                 470                 475                 480 
Gln Pro Pro Leu Phe Thr His Thr Val Lys Asp Arg Asp His Ile Ser 
                485                 490                 495     
Thr Arg Phe Leu Gly Gly Met Asp Ser Leu Thr Ser Ser Glu Glu Ser 
            500                 505                 510         
Ser Glu Arg Pro Pro Leu Ser Thr Leu Thr Leu Lys Glu Ala Asp Pro 
        515                 520                 525             
Ser Ser Lys Ala Ala Met Arg Arg Lys Asp Ser Pro Pro Pro Gly Lys 
    530                 535                 540                 
Val Ser Ser Gln Lys Gln Pro Ala Glu Lys Ala Thr Ser Asp Asp Lys 
545                 550                 555                 560 
Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Glu Gly Pro Ile Ser 
                565                 570                 575     
Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Glu Lys Ala Thr Ser Asp 
            580                 585                 590         
Glu Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Lys Gly Gln 
        595                 600                 605             
Gln Ser Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Trp Lys Val Ile 
    610                 615                 620                 
Phe Lys Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile Met Gly 
625                 630                 635                 640 
Gly Gly Lys Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Ser Lys 
                645                 650                 655     
Ala Thr Ser Asp Lys Thr Asp Ser Ala Leu Asn Ile Ala Thr Glu Ile 
            660                 665                 670         
Lys Asp Gly Leu Gln Cys Gly Thr Val Ser Ser Gln Lys Gln Pro Ala 
        675                 680                 685             
Leu Lys Ala Thr Thr Asp Glu Glu Asp Ser Val Ser Asn Ile Ala Thr 
    690                 695                 700                 
Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser Ser Gln Lys Gln 
705                 710                 715                 720 
Pro Ala Leu Lys Ala Thr Thr Asp Glu Glu Asp Ser Val Ser Asn Ile 
                725                 730                 735     
Ala Thr Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser Ser Gln 
            740                 745                 750         
Lys Gln Pro Ala Leu Lys Ala Thr Thr Asp Glu Lys Asp Ser Val Ser 
        755                 760                 765             
Asn Ile Ala Thr Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser 
    770                 775                 780                 
Ser Gln Lys Pro Pro Ala Leu Thr Ala Thr Ser Asp Glu Glu Gly Ser 
785                 790                 795                 800 
Val Leu Ser Ile Ala Arg Glu Asn Lys Asp Gly Glu Lys Ser Arg Thr 
                805                 810                 815     
Val Ser Ser Arg Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp Glu Lys 
            820                 825                 830         
Asp Ser Phe Ser Asn Ile Thr Arg Gly Lys Lys Asp Gly Glu Ile Ser 
        835                 840                 845             
Arg Lys Val Ser Ser Gln Lys Pro Pro Thr Leu Lys Gly Thr Ser Asp 
    850                 855                 860                 
Glu Glu Asp Ser Val Leu Gly Ile Ala Arg Glu Asn Lys Asp Gly Glu 
865                 870                 875                 880 
Lys Ser Arg Thr Val Ser Ser Glu Lys Pro Pro Gly Leu Lys Ala Ser 
                885                 890                 895     
Ser Ala Glu Lys Asp Ser Val Leu Asn Ile Ala Arg Gly Lys Lys Asp 
            900                 905                 910         
Gly Glu Lys Thr Lys Arg Val Ser Ser Arg Lys Lys Pro Ser Leu Glu 
        915                 920                 925             
Ala Thr Ser Asp Glu Lys Asp Ser Phe Ser Asn Ile Thr Arg Glu Lys 
    930                 935                 940                 
Lys Asp Gly Glu Ile Ser Arg Lys Val Ser Ser Gln Lys Pro Pro Ala 
945                 950                 955                 960 
Leu Lys Gly Thr Ser Asp Glu Glu Asp Ser Val Leu Gly Ile Ala Arg 
                965                 970                 975     
Glu Asn Lys Asp Gly Glu Lys Ser Arg Thr Val Ser Ser Glu Lys Pro 
            980                 985                 990         
Pro Gly Leu Lys Ala Thr Ser Asp Glu Lys Asp Ser Val Leu Asn Ile 
        995                 1000                1005            
Ala Arg Gly Lys Lys Asp Gly Glu Lys Thr Arg Thr Val Ser Ser Gln 
    1010                1015                1020                
Lys Pro Pro Thr Leu Lys Ala Thr Ser Asp Glu Glu Asp Ser Val Leu 
1025                1030                1035                1040
Ser Ile Ala Arg Glu Asn Lys Asp Gly Glu Lys Ser Arg Thr Val Ser 
                1045                1050                1055    
Ser Glu Lys Pro Ser Gly Leu Lys Ala Thr Ser Ala Glu Lys Asp Ser 
            1060                1065                1070        
Val Leu Asn Ile Ala Arg Gly Lys Lys Tyr Gly Glu Lys Thr Lys Arg 
        1075                1080                1085            
Val Ser Ser Arg Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp Glu Lys 
    1090                1095                1100                
Asp Ser Val Leu Tyr Ile Ala Arg Glu Lys Lys Asp Gly Glu Lys Ser 
1105                1110                1115                1120
Arg Thr Val Ser Ser Pro Lys Gln Pro Ala Leu Lys Ala Ile Cys Asp 
                1125                1130                1135    
Lys Glu Asp Ser Val Pro Asn Met Ala Thr Glu Lys Lys Asp Glu Gln 
            1140                1145                1150        
Ile Ser Gly Thr Val Ser Cys Gln Lys Gln Pro Ala Leu Lys Ala Thr 
        1155                1160                1165            
Ser Asp Lys Lys Asp Ser Val Ser Asn Ile Pro Thr Glu Ile Lys Asp 
    1170                1175                1180                
Gly Gln Gln Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Trp Lys 
1185                1190                1195                1200
Ala Thr Ser Val Lys Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile 
                1205                1210                1215    
Lys Asp Gly Gln Ile Arg Gly Thr Gly Ile Leu Glu Tyr Thr Phe Asn 
            1220                1225                1230        
Val Met Phe Asp Gln Ile Glu Glu Lys Phe Thr Ser Leu Asn Lys Ser 
        1235                1240                1245            
Ala Gly Val Ser Pro Gln Lys Gln Ser Ala Gln Lys Val Ile Phe Lys 
    1250                1255                1260                
Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile Thr Gly Gly Trp 
1265                1270                1275                1280
Lys Ser Gly Thr Glu Tyr Pro Glu Asn Leu Pro Thr Leu Lys Ala Thr 
                1285                1290                1295    
Ile Glu Asn Lys Asn Ser Val Leu Asn Thr Ala Thr Lys Met Lys Asp 
            1300                1305                1310        
Val Gln Thr Ser Thr Pro Ala Glu Gln Asp Leu Glu Met Ala Ser Glu 
        1315                1320                1325            
Gly Glu Gln Lys Arg Leu Glu Glu Tyr Glu Asn Asn Gln Pro Gln Val 
    1330                1335                1340                
Lys Asn Gln Ile His Ser Arg Asp Asp Leu Asp Asp Ile Ile Gln Ser 
1345                1350                1355                1360
Ser Gln Thr Val Ser Glu Asp Gly Asp Ser Leu Cys Cys Asn Cys Lys 
                1365                1370                1375    
Asn Val Ile Leu Leu Ile Asp Gln His Glu Met Lys Cys Lys Asp Cys 
            1380                1385                1390        
Val His Leu Leu Lys Ile Lys Asn Thr Phe Cys Leu Trp Lys Arg Leu 
        1395                1400                1405            
Ile Lys Leu Lys Asp Asn His Cys Glu Gln Leu Arg Val Lys Ile Arg 
    1410                1415                1420                
Lys Leu Lys Asn Lys Ala Ser Val Leu Gln Lys Arg Ile Ser Glu Lys 
1425                1430                1435                1440
Glu Glu Ile Lys Ser Gln Leu Lys His Glu Ile Leu Glu Leu Glu Lys 
                1445                1450                1455    
Glu Leu Cys Ser Leu Arg Phe Ala Ile Gln Gln Glu Lys Lys Lys Arg 
            1460                1465                1470        
Arg Asn Val Glu Glu Val His Gln Lys Val Arg Glu Lys Leu Arg Ile 
        1475                1480                1485            
Thr Glu Glu Gln Tyr Arg Ile Glu Ala Asp Val Thr Lys Pro Ile Lys 
    1490                1495                1500                
Pro Ala Leu Lys Ser Ala Glu Val Glu Leu Lys Thr Gly Gly Asn Asn 
1505                1510                1515                1520
Ser Asn Gln Val Ser Glu Thr Asp Glu Lys Glu Asp Leu Leu His Glu 
                1525                1530                1535    
Asn Arg Leu Met Gln Asp Glu Ile Ala Arg Leu Arg Leu Glu Lys Asp 
            1540                1545                1550        
Thr Ile Lys Asn Gln Asn Leu Glu Lys Lys Tyr Leu Lys Asp Phe Glu 
        1555                1560                1565            
Ile Val Lys Arg Lys His Glu Asp Leu Gln Lys Ala Leu Lys Arg Asn 
    1570                1575                1580                
Gly Glu Thr Leu Ala Lys Thr Ile Ala Cys Tyr Ser Gly Gln Leu Ala 
1585                1590                1595                1600
Ala Leu Thr Asp Glu Asn Thr Thr Leu Arg Ser Lys Leu Glu Lys Gln 
                1605                1610                1615    
Arg Glu Ser Arg Gln Arg Leu Glu Thr Glu Met Gln Ser Tyr His Cys 
            1620                1625                1630        
Arg Leu Asn Ala Ala Arg Cys Asp His Asp Gln Ser His Ser Ser Lys 
        1635                1640                1645            
Arg Asp Gln Glu Leu Ala Phe Gln Gly Thr Val Asp Lys Cys Arg His 
    1650                1655                1660                
Leu Gln Glu Asn Leu Asn Ser His Val Leu Ile Leu Ser Leu Gln Leu 
1665                1670                1675                1680
Ser Lys Ala Glu Ser Lys Ser Arg Val Leu Lys Thr Glu Leu His Tyr 
                1685                1690                1695    
Thr Gly Glu Ala Leu Lys Glu Lys Ala Leu Val Phe Glu His Val Gln 
            1700                1705                1710        
Ser Glu Leu Lys Gln Lys Gln Ser Gln Met Lys Asp Ile Glu Lys Met 
        1715                1720                1725            
Tyr Lys Ser Gly Tyr Asn Thr Met Glu Lys Cys Ile Glu Lys Gln Glu 
    1730                1735                1740                
Arg Phe Cys Gln Leu Lys Lys Gln Asn Met Leu Leu Gln Gln Gln Leu 
1745                1750                1755                1760
Asp Asp Ala Arg Asn Lys Ala Asp Asn Gln Glu Lys Ala Ile Leu Asn 
                1765                1770                1775    
Ile Gln Ala Arg Cys Asp Ala Arg Val Gln Asn Leu Gln Ala Glu Cys 
            1780                1785                1790        
Arg Lys His Arg Leu Leu Leu Glu Glu Asp Asn Lys Met Leu Val Asn 
        1795                1800                1805            
Glu Leu Asn His Ser Lys Glu Lys Glu Cys Gln Tyr Glu Lys Glu Lys 
    1810                1815                1820                
Ala Glu Arg Glu Val Ala Val Arg Gln Leu Gln Gln Lys Arg Asp Asp 
1825                1830                1835                1840
Val Leu Asn Lys Gly Ser Ala Thr Lys Ala Leu Leu Asp Ala Ser Ser 
                1845                1850                1855    
Arg His Cys Thr Tyr Leu Glu Asn Gly Met Gln Asp Ser Arg Lys Lys 
            1860                1865                1870        
Leu Asp Gln Met Arg Ser Gln Phe Gln Glu Ile Gln Asp Gln Leu Thr 
        1875                1880                1885            
Ala Thr Ile Arg Cys Thr Lys Glu Met Glu Gly Asp Thr Gln Lys Leu 
    1890                1895                1900                
Glu Val Glu His Val Met Met Arg Lys Ile Ile Lys Lys Gln Asp Asp 
1905                1910                1915                1920
Gln Ile Glu Arg Leu Glu Lys Ile Leu Gln His Ser Ser Leu Met Leu 
                1925                1930                1935    
Gln Val Phe Glu Ser 
            1940    

<210> 126
<211> 1235
<212> PRT
<213> human

<400> 126
Met Ala His Leu Glu Leu Leu Leu Val Glu Asn Phe Lys Ser Trp Arg 
1               5                   10                  15      
Gly Arg Gln Val Ile Gly Pro Phe Arg Arg Phe Thr Cys Ile Ile Gly 
            20                  25                  30          
Pro Asn Gly Ser Gly Lys Ser Asn Val Met Asp Ala Leu Ser Phe Val 
        35                  40                  45              
Met Gly Glu Lys Ile Ala Asn Leu Arg Val Lys Asn Ile Gln Glu Leu 
    50                  55                  60                  
Ile His Gly Ala His Ile Gly Lys Pro Ile Ser Ser Ser Ala Ser Val 
65                  70                  75                  80  
Lys Ile Ile Tyr Val Glu Glu Ser Gly Glu Glu Lys Thr Phe Ala Arg 
                85                  90                  95      
Ile Ile Arg Gly Gly Cys Ser Glu Phe Arg Phe Asn Asp Asn Leu Val 
            100                 105                 110         
Ser Arg Ser Val Tyr Ile Ala Glu Leu Glu Lys Ile Gly Ile Ile Val 
        115                 120                 125             
Lys Ala Gln Asn Cys Leu Val Phe Gln Gly Thr Val Glu Ser Ile Ser 
    130                 135                 140                 
Val Lys Lys Pro Lys Glu Arg Thr Gln Phe Phe Glu Glu Ile Ser Thr 
145                 150                 155                 160 
Ser Gly Glu Leu Ile Gly Glu Tyr Glu Glu Lys Lys Arg Lys Leu Gln 
                165                 170                 175     
Lys Ala Glu Glu Asp Ala Gln Phe Asn Phe Asn Lys Lys Lys Asn Ile 
            180                 185                 190         
Ala Ala Glu Arg Arg Gln Ala Lys Leu Glu Lys Glu Glu Ala Glu Arg 
        195                 200                 205             
Tyr Gln Ser Leu Leu Glu Glu Leu Lys Met Asn Lys Ile Gln Leu Gln 
    210                 215                 220                 
Leu Phe Gln Leu Tyr His Asn Glu Lys Lys Ile His Leu Leu Asn Thr 
225                 230                 235                 240 
Lys Leu Glu His Val Asn Arg Asp Leu Ser Val Lys Arg Glu Ser Leu 
                245                 250                 255     
Ser His His Glu Asn Ile Val Lys Ala Arg Lys Lys Glu His Gly Met 
            260                 265                 270         
Leu Thr Arg Gln Leu Gln Gln Thr Glu Lys Glu Leu Lys Ser Val Glu 
        275                 280                 285             
Thr Leu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn 
    290                 295                 300                 
Thr Ser His His Leu Lys Lys Leu Asp Val Ala Lys Lys Ser Ile Lys 
305                 310                 315                 320 
Asp Ser Glu Lys Gln Cys Ser Lys Gln Glu Asp Asp Ile Lys Ala Leu 
                325                 330                 335     
Glu Thr Glu Leu Ala Asp Leu Asp Ala Ala Trp Arg Ser Phe Glu Lys 
            340                 345                 350         
Gln Ile Glu Glu Glu Ile Leu His Lys Lys Arg Asp Ile Glu Leu Glu 
        355                 360                 365             
Ala Ser Gln Leu Asp Arg Tyr Lys Glu Leu Lys Glu Gln Val Arg Lys 
    370                 375                 380                 
Lys Val Ala Thr Met Thr Gln Gln Leu Glu Lys Leu Gln Trp Glu Gln 
385                 390                 395                 400 
Lys Thr Asp Glu Glu Arg Leu Ala Phe Glu Lys Arg Arg His Gly Glu 
                405                 410                 415     
Val Gln Gly Asn Leu Lys Gln Ile Lys Glu Gln Ile Glu Asp His Lys 
            420                 425                 430         
Lys Arg Ile Glu Lys Leu Glu Glu Tyr Thr Lys Thr Cys Met Asp Cys 
        435                 440                 445             
Leu Lys Glu Lys Lys Gln Gln Glu Glu Thr Leu Val Asp Glu Ile Glu 
    450                 455                 460                 
Lys Thr Lys Ser Arg Met Ser Glu Phe Asn Glu Glu Leu Asn Leu Ile 
465                 470                 475                 480 
Arg Ser Glu Leu Gln Asn Ala Gly Ile Asp Thr His Glu Gly Lys Arg 
                485                 490                 495     
Gln Gln Lys Arg Ala Glu Val Leu Glu His Leu Lys Arg Leu Tyr Pro 
            500                 505                 510         
Asp Ser Val Phe Gly Arg Leu Phe Asp Leu Cys His Pro Ile His Lys 
        515                 520                 525             
Lys Tyr Gln Leu Ala Val Thr Lys Val Phe Gly Arg Phe Ile Thr Ala 
    530                 535                 540                 
Ile Val Val Ala Ser Glu Lys Val Ala Lys Asp Cys Ile Arg Phe Leu 
545                 550                 555                 560 
Lys Glu Glu Arg Ala Glu Pro Glu Thr Phe Leu Ala Leu Asp Tyr Leu 
                565                 570                 575     
Asp Ile Lys Pro Ile Asn Glu Arg Leu Arg Glu Leu Lys Gly Cys Lys 
            580                 585                 590         
Met Val Ile Asp Val Ile Lys Thr Gln Phe Pro Gln Leu Lys Lys Val 
        595                 600                 605             
Ile Gln Phe Val Cys Gly Asn Gly Leu Val Cys Glu Thr Met Glu Glu 
    610                 615                 620                 
Ala Arg His Ile Ala Leu Ser Gly Pro Glu Arg Gln Lys Thr Val Ala 
625                 630                 635                 640 
Leu Asp Gly Thr Leu Phe Leu Lys Ser Gly Val Ile Ser Gly Gly Ser 
                645                 650                 655     
Ser Asp Leu Lys Tyr Lys Ala Arg Cys Trp Asp Glu Lys Glu Leu Lys 
            660                 665                 670         
Asn Leu Arg Asp Arg Arg Ser Gln Lys Ile Gln Glu Leu Lys Gly Leu 
        675                 680                 685             
Met Lys Thr Leu Arg Lys Glu Thr Asp Leu Lys Gln Ile Gln Thr Leu 
    690                 695                 700                 
Ile Gln Gly Thr Gln Thr Arg Leu Lys Tyr Ser Gln Asn Glu Leu Glu 
705                 710                 715                 720 
Met Ile Lys Lys Lys His Leu Val Ala Phe Tyr Gln Glu Gln Ser Gln 
                725                 730                 735     
Leu Gln Ser Glu Leu Leu Asn Ile Glu Ser Gln Cys Ile Met Leu Ser 
            740                 745                 750         
Glu Gly Ile Lys Glu Arg Gln Arg Arg Ile Lys Glu Phe Gln Glu Lys 
        755                 760                 765             
Ile Asp Lys Val Glu Asp Asp Ile Phe Gln His Phe Cys Glu Glu Ile 
    770                 775                 780                 
Gly Val Glu Asn Ile Arg Glu Phe Glu Asn Lys His Val Lys Arg Gln 
785                 790                 795                 800 
Gln Glu Ile Asp Gln Lys Arg Tyr Phe Tyr Lys Lys Met Leu Thr Arg 
                805                 810                 815     
Leu Asn Val Gln Leu Glu Tyr Ser Arg Ser His Leu Lys Lys Lys Leu 
            820                 825                 830         
Asn Lys Ile Asn Thr Leu Lys Glu Thr Ile Gln Lys Gly Ser Glu Asp 
        835                 840                 845             
Ile Asp His Leu Lys Lys Ala Glu Glu Asn Cys Leu Gln Thr Val Asn 
    850                 855                 860                 
Glu Leu Met Ala Lys Gln Gln Gln Leu Lys Asp Ile Arg Val Thr Gln 
865                 870                 875                 880 
Asn Ser Ser Ala Glu Lys Val Gln Thr Gln Ile Glu Glu Glu Arg Lys 
                885                 890                 895     
Lys Phe Leu Ala Val Asp Arg Glu Val Gly Lys Leu Gln Lys Glu Val 
            900                 905                 910         
Val Ser Ile Gln Thr Ser Leu Glu Gln Lys Arg Leu Glu Lys His Asn 
        915                 920                 925             
Leu Leu Leu Asp Cys Lys Val Gln Asp Ile Glu Ile Ile Leu Leu Ser 
    930                 935                 940                 
Gly Ser Leu Asp Asp Ile Ile Glu Val Glu Met Gly Thr Glu Ala Glu 
945                 950                 955                 960 
Ser Thr Gln Ala Thr Ile Asp Ile Tyr Glu Lys Glu Glu Ala Phe Glu 
                965                 970                 975     
Ile Asp Tyr Ser Ser Leu Lys Glu Asp Leu Lys Ala Leu Gln Ser Asp 
            980                 985                 990         
Gln Glu Ile Glu Ala His Leu Arg Leu Leu Leu Gln Gln Val Ala Ser 
        995                 1000                1005            
Gln Glu Asp Ile Leu Leu Lys Thr Ala Ala Pro Asn Leu Arg Ala Leu 
    1010                1015                1020                
Glu Asn Leu Lys Thr Val Arg Asp Lys Phe Gln Glu Ser Thr Asp Ala 
1025                1030                1035                1040
Phe Glu Ala Ser Arg Lys Glu Ala Arg Leu Cys Arg Gln Glu Phe Glu 
                1045                1050                1055    
Gln Val Lys Lys Arg Arg Tyr Asp Leu Phe Thr Gln Cys Phe Glu His 
            1060                1065                1070        
Val Ser Ile Ser Ile Asp Gln Ile Tyr Lys Lys Leu Cys Arg Asn Asn 
        1075                1080                1085            
Ser Ala Gln Ala Phe Leu Ser Pro Glu Asn Pro Glu Glu Pro Tyr Leu 
    1090                1095                1100                
Glu Gly Ile Ser Tyr Asn Cys Val Ala Pro Gly Lys Arg Phe Met Pro 
1105                1110                1115                1120
Met Asp Asn Leu Ser Gly Gly Glu Lys Cys Val Ala Ala Leu Ala Leu 
                1125                1130                1135    
Leu Phe Ala Val His Ser Phe Arg Pro Ala Pro Phe Phe Val Leu Asp 
            1140                1145                1150        
Glu Val Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly Lys Val Ser Ser 
        1155                1160                1165            
Tyr Ile Lys Glu Gln Thr Gln Asp Gln Phe Gln Met Ile Val Ile Ser 
    1170                1175                1180                
Leu Lys Glu Glu Phe Tyr Ser Arg Ala Asp Ala Leu Ile Gly Ile Tyr 
1185                1190                1195                1200
Pro Glu Tyr Asp Asp Cys Met Phe Ser Arg Val Leu Thr Leu Asp Leu 
                1205                1210                1215    
Ser Gln Tyr Pro Asp Thr Glu Gly Gln Glu Ser Ser Lys Arg His Gly 
            1220                1225                1230        
Glu Ser Arg 
        1235

<210> 127
<211> 1692
<212> PRT
<213> human

<400> 127
Met Arg Arg Pro Pro Pro Leu Gly Pro Thr Thr Ala Ser Gly Pro Glu 
1               5                   10                  15      
Gly Asn Val Arg Asn Leu Gln Lys Arg Gln Ala Pro Gly Pro Gly Ala 
            20                  25                  30          
Ala Gly Gly Cys Gly Pro Glu Ala Gly Gly Cys Arg Glu Asn Lys Gln 
        35                  40                  45              
Lys Arg Arg Met Val Ala Arg Ala Thr Pro Gly Arg Gly Glu Val Glu 
    50                  55                  60                  
Ser Asp Lys Ser Val Ala Ala Ser Gly Ala Gly Lys Ala Ala Arg Arg 
65                  70                  75                  80  
Gln Val Glu Gly Arg Arg Gly Pro Val Ser Pro Ser Asp Ser Ser Asp 
                85                  90                  95      
Pro Arg Gly Leu Glu Ala Ala Lys Glu Ala Glu Leu Pro Leu Gln Thr 
            100                 105                 110         
Glu Arg His Thr Lys Glu Lys Arg Lys Val Thr Glu Ala Ser Ser Asp 
        115                 120                 125             
Asp Pro Gln Pro Gly Leu Asp Leu Val Arg Lys Glu Ser Leu Thr Ser 
    130                 135                 140                 
Ser Glu Ser Phe Gln Thr Val Glu Cys Leu Gln Ser Leu Gly Lys Glu 
145                 150                 155                 160 
Ser Ile Ile Glu Gly Ile Lys Arg Arg Ile Arg Asn Lys Lys Leu Lys 
                165                 170                 175     
Ser Leu Glu Asn Pro Pro Leu Lys Ile Thr Glu Asn Glu Ala Thr Gln 
            180                 185                 190         
Asn Ile Lys Val Glu Phe Gln Asp Glu Leu Tyr Lys Asn Thr Pro Lys 
        195                 200                 205             
Tyr Ser Cys Asn Ile Leu Ser Pro Glu Val Glu Asn Asn Ser Val Leu 
    210                 215                 220                 
Lys Leu Arg Asp Cys Asn Cys Phe Pro His Ser Lys Gly Cys Asn Asp 
225                 230                 235                 240 
Glu Asn Asn Leu Pro Tyr Lys Pro Asp Gly Gly Cys Met His Val Ala 
                245                 250                 255     
Glu Asn Phe Ser Lys Lys Glu Asn Leu Arg Ser Leu Ala Glu Lys Ser 
            260                 265                 270         
Asp Thr Asn Ser Ile Pro Gln Leu Leu Gln Thr Glu Glu Asn Val Met 
        275                 280                 285             
Gly Val Asn Lys Leu Leu Pro Glu Glu Ser Asp Leu Tyr Gln Ser Lys 
    290                 295                 300                 
Thr Asn Gly Leu Leu Ser Cys Leu Gln His Glu Lys Asn Lys Tyr Ser 
305                 310                 315                 320 
Ile Glu Glu Ser Ser Val Gly Arg Lys Pro Arg Lys Arg Met Lys Leu 
                325                 330                 335     
Ser Glu Lys Ala Asp Glu Thr Val Thr Glu Met Asn Phe Ser Asn Glu 
            340                 345                 350         
Tyr Asn Lys Ser Glu Leu Met Leu Gln Glu Asn Gln Met Ile Ala Asp 
        355                 360                 365             
Gly Lys Glu Ala Glu Thr Lys Ser Pro Leu Asn Val Leu Arg Lys Val 
    370                 375                 380                 
Ser His Asn Thr Val Ser Leu Met Asp His Leu Leu Ser Val Pro Glu 
385                 390                 395                 400 
Thr Val Glu Lys Glu Thr Ser Ser Glu His His Val Asn Ala Val Phe 
                405                 410                 415     
Gln Lys Thr Ile Glu Pro Leu Leu Lys Glu Glu Thr Glu Asn Ala Ser 
            420                 425                 430         
Glu Pro Leu Gly Tyr Glu Ser Met Ala Ser Lys Glu Asp Phe Lys Ser 
        435                 440                 445             
Met Lys Ser Phe Ile Gly Lys Ser Pro Asn Glu Tyr His Ile Glu Arg 
    450                 455                 460                 
Arg Ser Ser Arg Glu Asp Leu Arg Ser Ala Ser Glu Glu Leu Lys Leu 
465                 470                 475                 480 
Ser Cys Gln Arg Thr Ile Pro Met Thr Gly Lys Arg Thr Trp Pro Tyr 
                485                 490                 495     
Tyr Ser Cys Ala Arg Ile Ser Ala Trp Cys Trp Lys Lys Ala Ser Leu 
            500                 505                 510         
Pro Glu Ser Ser Tyr Phe Leu Arg Gly Ser Gln Glu Ser Cys Arg Gln 
        515                 520                 525             
Val Asp Val Pro Lys His Gln Thr Asn Gln Thr His Leu Thr Asp Ser 
    530                 535                 540                 
Lys Leu Leu Leu Gln Ser Ser Leu Thr Glu Thr Asn Thr Glu Ser Ser 
545                 550                 555                 560 
Ser Lys Glu Lys Leu Asp Ser Asn Ser Asn Cys Leu Ser Ser Val Ser 
                565                 570                 575     
Ala Val Glu Pro Thr Leu Met Val Ile Lys Glu Pro Ile Ile Lys Asp 
            580                 585                 590         
Asp Lys Lys Ile Lys Ser Glu Glu Leu Ser Arg Arg Gly Ser Glu Val 
        595                 600                 605             
Ile Ser Asn Thr Thr Glu Asp Thr Gln Leu Thr Ser Glu Thr Gln Ser 
    610                 615                 620                 
Leu Thr Gly Asn Lys Lys Lys Ala Arg Gly Asn Leu Thr Lys Leu Asn 
625                 630                 635                 640 
Leu Thr Ala Thr Ser Lys Asp Gly Gln Glu Ala Asn Asn Ser Ala Gly 
                645                 650                 655     
Lys Thr Ile His Arg Lys Ala Cys Ile Ala Gln Gln Thr Phe Ile Val 
            660                 665                 670         
Pro Asp Leu Val Lys Ile Leu Asn Thr Gly Arg Leu Thr Asn Phe Lys 
        675                 680                 685             
Ile Pro Leu Leu Lys Asn Lys Ser Glu Lys Arg Lys Glu Val Asn Ala 
    690                 695                 700                 
Lys Ser Ser Glu Arg Glu Ala Tyr Ser Pro Leu Glu Leu Leu Asp Asn 
705                 710                 715                 720 
Leu Ser Gly Ala Asp Val Arg Gln Asn Arg Ser Lys Glu Asn Val Ser 
                725                 730                 735     
Met Met Met Leu Gly Pro Gln Thr Leu Ser Ile Arg Asn Ser Val Thr 
            740                 745                 750         
Pro Val Gln Ala Ser Ser Asp Ser Phe Tyr Asn Lys Lys Ser Tyr Ser 
        755                 760                 765             
Ile Ser Pro Ser Phe Thr Lys Gln Gly Asn Asn Ser Lys Pro Ser Asn 
    770                 775                 780                 
His Val Ser Glu Pro Gly Asn Ile Val Ser Asn Lys Glu Val Ala Ser 
785                 790                 795                 800 
Leu Thr Val Glu Asn Asn Ala Phe Ser Cys Asp Pro Gly Tyr Val Glu 
                805                 810                 815     
Lys Ser Pro Ser Phe Cys Cys Asn Glu Gln Glu Thr Phe Arg Pro Val 
            820                 825                 830         
Ser Ser Glu Val Arg Gly Arg Lys Ile Thr Lys Asn Phe Ser Glu Val 
        835                 840                 845             
Gly Phe Pro Asp Ile Leu Lys Ala Tyr Glu Asp Asp Val Leu Leu Ile 
    850                 855                 860                 
Asp Val Ile Gln Asp Asp Pro Asp Leu Phe Gly Val Ser Asn Glu Gly 
865                 870                 875                 880 
Glu Leu Ser Phe Thr Ser Glu Val Pro Lys Ile Ser Gln Glu Pro Asn 
                885                 890                 895     
Val Ala Gly Glu His Gln Ser Thr Asp Ser Lys Tyr Met Glu Thr Pro 
            900                 905                 910         
Val Lys Lys Glu Pro Ser Asp Asp Leu Arg Glu Leu Pro Val Leu Asp 
        915                 920                 925             
Cys Gly Trp Ile Lys Pro Asp Ile Cys Ala Ser Asn Ser Ala Glu Ser 
    930                 935                 940                 
Glu Ile Lys Arg Asp Pro Lys Asp Val Asn Thr Ser Leu Gly Glu Val 
945                 950                 955                 960 
Ala Asn Glu Thr Ser Glu Asn Glu Thr Leu Gly Asp Phe Ser Glu Gln 
                965                 970                 975     
Ile Lys Gly Ser Asp Leu Asp Glu Lys His Arg Phe Thr Asp Lys Val 
            980                 985                 990         
Ile Thr Lys Glu Glu Lys Glu Asn Ile Tyr Glu Val Cys Lys Ser Lys 
        995                 1000                1005            
Asp Ser Arg Asn Ala Asp Phe Met Val Gly Glu Cys Gln Phe Ala Val 
    1010                1015                1020                
Pro Val Pro Lys Pro Leu Cys Leu Leu Val Pro Pro Leu Asn Leu Ser 
1025                1030                1035                1040
Gly Arg Gln Glu Asp Thr Ile Leu Asn Thr Trp Met Asn Asp Phe Arg 
                1045                1050                1055    
Phe Leu Gly Lys His Ser Val Leu Lys Leu Gln Asn Pro Glu Thr Cys 
            1060                1065                1070        
Glu Ile Phe Lys Arg Glu Lys Asn Val Gly Val Phe Gln Lys Ser Leu 
        1075                1080                1085            
Gly Leu Met Ile Pro Tyr Lys Tyr Cys Lys Phe His Phe Asn Thr Leu 
    1090                1095                1100                
Arg Gly Cys Glu Arg Pro Leu Cys Lys Phe Ala His Val Pro Glu Gln 
1105                1110                1115                1120
Gly Asp Glu Lys Val Cys Met Asp Val Phe Lys Lys Tyr Ile Asn Ile 
                1125                1130                1135    
Asn Glu Leu Cys Leu Leu Gln Arg Ala Val Asn Ile Phe Met Glu Tyr 
            1140                1145                1150        
Tyr Arg Lys Phe Pro Pro Gly Val Tyr Phe Asp Leu Gln Val Leu Asn 
        1155                1160                1165            
Asp Leu Leu Asn Ser Leu Leu Lys His Cys Leu Leu Lys Glu Val Phe 
    1170                1175                1180                
Gln Ile Val Asn Leu Ser Ile Met Val Lys Met Leu Pro Ser Leu Lys 
1185                1190                1195                1200
Ile Leu Leu Asn Ile Phe Glu Tyr Val Ala Thr Met Lys Leu Arg Asn 
                1205                1210                1215    
Ala Val Pro Ala Leu Ile Asp Ile Phe Cys Lys Leu Val Glu Ala Gly 
            1220                1225                1230        
Met Val Leu Asp Pro Glu His Phe Asn Tyr Ile Val Lys Leu Leu Tyr 
        1235                1240                1245            
Gln Val Gln Ala Ser Lys Gln Glu Ile Thr Ala Val Leu Glu Met Lys 
    1250                1255                1260                
Ser Arg Leu Gln Met Arg Arg Phe Lys Lys Asn Trp Lys Cys Asp Leu 
1265                1270                1275                1280
Asp Ser Ala Leu Asn Lys Leu Glu His Cys Lys Glu Lys Gly Asp Trp 
                1285                1290                1295    
Thr Lys Leu Gly Lys Leu Tyr Ile Asn Val Lys Met Gly Cys Glu Lys 
            1300                1305                1310        
Phe Ala Asp Phe Gln Thr Phe Cys Ala Cys Ile Ala Glu Thr Leu Thr 
        1315                1320                1325            
Lys Asn Tyr Glu Asp Glu Arg Pro Asp Ile Pro Phe Cys Glu Phe Ala 
    1330                1335                1340                
Glu Thr Val Ser Lys Asp Pro Gln Asn Ser Lys Val Asp Lys Gly Val 
1345                1350                1355                1360
Leu Gly Arg Ile Gly Ile Ser Ala Met Tyr Phe Tyr His Lys Leu Leu 
                1365                1370                1375    
Gln Trp Ser Lys Gly Arg Lys Val Leu Glu Lys Leu Tyr Glu Leu Lys 
            1380                1385                1390        
Ile His Phe Thr Ser Leu Lys Gly Leu Ile Gly Pro Glu Lys Leu Ala 
        1395                1400                1405            
Ser Arg Cys Gln Ile Val Asn Val Ala Ala Glu Ile Phe Leu Lys Ser 
    1410                1415                1420                
Gly Ser Leu Asp Gly Ala Ile Trp Val Met Arg Glu Ser Glu Trp Ile 
1425                1430                1435                1440
Ile Asn Thr Pro Leu Trp Pro Cys Asp Arg Leu Asp Val Leu Asn Arg 
                1445                1450                1455    
His Asn Leu Leu Cys Thr Ile Ala His Glu Ile Leu Ala Lys Ser Leu 
            1460                1465                1470        
Tyr Arg Gln Thr Phe Glu Val Leu Gln Asn Leu Pro Gly Phe Gln Asn 
        1475                1480                1485            
Ser Gln Glu Thr Val Glu Val Ser Gln Tyr Ser Leu Leu Phe Asn Lys 
    1490                1495                1500                
Leu Leu Gly Ser Cys Ile Glu Ser Ser Ser Leu Gly Met Ser Ser Ser 
1505                1510                1515                1520
Val Ala Glu Phe Met Ile Ser Lys Ser Ile Pro Ile Asp Phe Ser Phe 
                1525                1530                1535    
Leu Arg Arg Leu Ile Thr Ser Leu Gly Arg Ser Arg Leu Trp Leu Lys 
            1540                1545                1550        
Ala Arg Ala His Tyr Lys Ser Ala Leu Ser Leu Gly Cys Tyr Pro Pro 
        1555                1560                1565            
Leu Glu Gly Asn Leu Tyr Arg Lys Leu Leu Leu Ile Pro Ser Tyr Leu 
    1570                1575                1580                
Ser Glu Ile Glu Met Leu Leu Ala Ile Glu Ile Phe Met Val Ser Asn 
1585                1590                1595                1600
Ala Ser Ser Ile Gln Ser Pro Gly Thr Ser Thr Gln Ile Leu Gln Ile 
                1605                1610                1615    
Val Leu Lys Arg Cys Glu Asp Asn Gln Ser Arg Ser Asn Asp Asp Tyr 
            1620                1625                1630        
Gln Ala Ala Val Glu Arg Leu Ile Met Ala Ala Arg Ile Ser Asp Pro 
        1635                1640                1645            
Lys Leu Phe Val Lys His Met Thr Val Asn Val Asn Lys Glu Gln Val 
    1650                1655                1660                
Tyr Ser Leu Glu His Cys Ser Ala Leu Lys Trp Leu Lys Glu Asn Met 
1665                1670                1675                1680
Lys Trp Ala Gly Lys Val Trp Leu Phe Ser Asn His 
                1685                1690        

<210> 128
<211> 3051
<212> PRT
<213> human

<400> 128
Met Ala Thr Asn Pro Gln Pro Gln Pro Pro Pro Pro Ala Pro Pro Pro 
1               5                   10                  15      
Pro Pro Pro Gln Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Gly Pro 
            20                  25                  30          
Gly Ala Gly Pro Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala 
        35                  40                  45              
Gly Asp Pro Gln Leu Val Ala Met Ile Val Asn His Leu Lys Ser Gln 
    50                  55                  60                  
Gly Leu Phe Asp Gln Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr 
65                  70                  75                  80  
Lys Pro Ala Tyr Gln Asn Leu Arg Gln Arg Val Asp Asn Phe Val Ala 
                85                  90                  95      
Asn His Leu Ala Thr His Thr Trp Ser Pro His Leu Asn Lys Asn Gln 
            100                 105                 110         
Leu Arg Asn Asn Ile Arg Gln Gln Val Leu Lys Ser Gly Met Leu Glu 
        115                 120                 125             
Ser Gly Ile Asp Arg Ile Ile Ser Gln Val Val Asp Pro Lys Ile Asn 
    130                 135                 140                 
His Thr Phe Arg Pro Gln Val Glu Lys Ala Val His Glu Phe Leu Ala 
145                 150                 155                 160 
Thr Leu Asn His Lys Glu Glu Gly Ser Gly Asn Thr Ala Pro Asp Asp 
                165                 170                 175     
Glu Lys Pro Asp Thr Ser Leu Ile Thr Gln Gly Val Pro Thr Pro Gly 
            180                 185                 190         
Pro Ser Ala Asn Val Ala Asn Asp Ala Met Ser Ile Leu Glu Thr Ile 
        195                 200                 205             
Thr Ser Leu Asn Gln Glu Ala Ser Ala Ala Arg Ala Ser Thr Glu Thr 
    210                 215                 220                 
Ser Asn Ala Lys Thr Ser Glu Arg Ala Ser Lys Lys Leu Pro Ser Gln 
225                 230                 235                 240 
Pro Thr Thr Asp Thr Ser Thr Asp Lys Glu Arg Thr Ser Glu Asp Met 
                245                 250                 255     
Ala Asp Lys Glu Lys Ser Thr Ala Asp Ser Gly Gly Glu Gly Leu Glu 
            260                 265                 270         
Thr Ala Pro Lys Ser Glu Glu Phe Ser Asp Leu Pro Cys Pro Val Glu 
        275                 280                 285             
Glu Ile Lys Asn Tyr Thr Lys Glu His Asn Asn Leu Ile Leu Leu Asn 
    290                 295                 300                 
Lys Asp Val Gln Gln Glu Ser Ser Glu Gln Lys Asn Lys Ser Thr Asp 
305                 310                 315                 320 
Lys Gly Glu Lys Lys Pro Asp Ser Asn Glu Lys Gly Glu Arg Lys Lys 
                325                 330                 335     
Glu Lys Lys Glu Lys Thr Glu Lys Lys Phe Asp His Ser Lys Lys Ser 
            340                 345                 350         
Glu Asp Thr Gln Lys Val Lys Asp Glu Lys Gln Ala Lys Glu Lys Glu 
        355                 360                 365             
Val Glu Ser Leu Lys Leu Pro Ser Glu Lys Asn Ser Asn Lys Ala Lys 
    370                 375                 380                 
Thr Val Glu Gly Thr Lys Glu Asp Phe Ser Leu Ile Asp Ser Asp Val 
385                 390                 395                 400 
Asp Gly Leu Thr Asp Ile Thr Val Ser Ser Val His Thr Ser Asp Leu 
                405                 410                 415     
Ser Ser Phe Glu Glu Asp Thr Glu Glu Glu Val Val Thr Ser Asp Ser 
            420                 425                 430         
Met Glu Glu Gly Glu Ile Thr Ser Asp Asp Glu Glu Lys Asn Lys Gln 
        435                 440                 445             
Asn Lys Thr Lys Thr Gln Thr Ser Asp Ser Ser Glu Gly Lys Thr Lys 
    450                 455                 460                 
Ser Val Arg His Ala Tyr Val His Lys Pro Tyr Leu Tyr Ser Lys Tyr 
465                 470                 475                 480 
Tyr Ser Asp Ser Asp Asp Glu Leu Thr Val Glu Gln Arg Arg Gln Ser 
                485                 490                 495     
Ile Ala Lys Glu Lys Glu Glu Arg Leu Leu Arg Arg Gln Ile Asn Arg 
            500                 505                 510         
Glu Lys Leu Glu Glu Lys Arg Lys Gln Lys Ala Glu Lys Thr Lys Ser 
        515                 520                 525             
Ser Lys Thr Lys Gly Gln Gly Arg Ser Ser Val Asp Leu Glu Glu Ser 
    530                 535                 540                 
Ser Thr Lys Ser Leu Glu Pro Lys Ala Ala Arg Ile Lys Glu Val Leu 
545                 550                 555                 560 
Lys Glu Arg Lys Val Leu Glu Lys Lys Val Ala Leu Ser Lys Lys Arg 
                565                 570                 575     
Lys Lys Asp Ser Arg Asn Val Glu Glu Asn Ser Lys Lys Lys Gln Gln 
            580                 585                 590         
Tyr Glu Glu Asp Ser Lys Glu Thr Leu Lys Thr Ser Glu His Cys Glu 
        595                 600                 605             
Lys Glu Lys Ile Ser Ser Ser Lys Glu Leu Lys His Val His Ala Lys 
    610                 615                 620                 
Ser Glu Pro Ser Lys Pro Ala Arg Arg Leu Ser Glu Ser Leu His Val 
625                 630                 635                 640 
Val Asp Glu Asn Lys Asn Glu Ser Lys Leu Glu Arg Glu His Lys Arg 
                645                 650                 655     
Arg Thr Ser Thr Pro Val Ile Met Glu Gly Val Gln Glu Glu Thr Asp 
            660                 665                 670         
Thr Arg Asp Val Lys Arg Gln Val Glu Arg Ser Glu Ile Cys Thr Glu 
        675                 680                 685             
Glu Pro Gln Lys Gln Lys Ser Thr Leu Lys Asn Glu Lys His Leu Lys 
    690                 695                 700                 
Lys Asp Asp Ser Glu Thr Pro His Leu Lys Ser Leu Leu Lys Lys Glu 
705                 710                 715                 720 
Val Lys Ser Ser Lys Glu Lys Pro Glu Arg Glu Lys Thr Pro Ser Glu 
                725                 730                 735     
Asp Lys Leu Ser Val Lys His Lys Tyr Lys Gly Asp Cys Met His Lys 
            740                 745                 750         
Thr Gly Asp Glu Thr Glu Leu His Ser Ser Glu Lys Gly Leu Lys Val 
        755                 760                 765             
Glu Glu Asn Ile Gln Lys Gln Ser Gln Gln Thr Lys Leu Ser Ser Asp 
    770                 775                 780                 
Asp Lys Thr Glu Arg Lys Ser Lys His Arg Asn Glu Arg Lys Leu Ser 
785                 790                 795                 800 
Val Leu Gly Lys Asp Gly Lys Pro Val Ser Glu Tyr Ile Ile Lys Thr 
                805                 810                 815     
Asp Glu Asn Val Arg Lys Glu Asn Asn Lys Lys Glu Arg Arg Leu Ser 
            820                 825                 830         
Ala Glu Lys Thr Lys Ala Glu His Lys Ser Arg Arg Ser Ser Asp Ser 
        835                 840                 845             
Lys Ile Gln Lys Asp Ser Leu Gly Ser Lys Gln His Gly Ile Thr Leu 
    850                 855                 860                 
Gln Arg Arg Ser Glu Ser Tyr Ser Glu Asp Lys Cys Asp Met Asp Ser 
865                 870                 875                 880 
Thr Asn Met Asp Ser Asn Leu Lys Pro Glu Glu Val Val His Lys Glu 
                885                 890                 895     
Lys Arg Arg Thr Lys Ser Leu Leu Glu Glu Lys Leu Val Leu Lys Ser 
            900                 905                 910         
Lys Ser Lys Thr Gln Gly Lys Gln Val Lys Val Val Glu Thr Glu Leu 
        915                 920                 925             
Gln Glu Gly Ala Thr Lys Gln Ala Thr Thr Pro Lys Pro Asp Lys Glu 
    930                 935                 940                 
Lys Asn Thr Glu Glu Asn Asp Ser Glu Lys Gln Arg Lys Ser Lys Val 
945                 950                 955                 960 
Glu Asp Lys Pro Phe Glu Glu Thr Gly Val Glu Pro Val Leu Glu Thr 
                965                 970                 975     
Ala Ser Ser Ser Ala His Ser Thr Gln Lys Asp Ser Ser His Arg Ala 
            980                 985                 990         
Lys Leu Pro Leu Ala Lys Glu Lys Tyr Lys Ser Asp Lys Asp Ser Thr 
        995                 1000                1005            
Ser Thr Arg Leu Glu Arg Lys Leu Ser Asp Gly His Lys Ser Arg Ser 
    1010                1015                1020                
Leu Lys His Ser Ser Lys Asp Ile Lys Lys Lys Asp Glu Asn Lys Ser 
1025                1030                1035                1040
Asp Asp Lys Asp Gly Lys Glu Val Asp Ser Ser His Glu Lys Ala Arg 
                1045                1050                1055    
Gly Asn Ser Ser Leu Met Glu Lys Lys Leu Ser Arg Arg Leu Cys Glu 
            1060                1065                1070        
Asn Arg Arg Gly Ser Leu Ser Gln Glu Met Ala Lys Gly Glu Glu Lys 
        1075                1080                1085            
Leu Ala Ala Asn Thr Leu Ser Thr Pro Ser Gly Ser Ser Leu Gln Arg 
    1090                1095                1100                
Pro Lys Lys Ser Gly Asp Met Thr Leu Ile Pro Glu Gln Glu Pro Met 
1105                1110                1115                1120
Glu Ile Asp Ser Glu Pro Gly Val Glu Asn Val Phe Glu Val Ser Lys 
                1125                1130                1135    
Thr Gln Asp Asn Arg Asn Asn Asn Ser Gln Gln Asp Ile Asp Ser Glu 
            1140                1145                1150        
Asn Met Lys Gln Lys Thr Ser Ala Thr Val Gln Lys Asp Glu Leu Arg 
        1155                1160                1165            
Thr Cys Thr Ala Asp Ser Lys Ala Thr Ala Pro Ala Tyr Lys Pro Gly 
    1170                1175                1180                
Arg Gly Thr Gly Val Asn Ser Asn Ser Glu Lys His Ala Asp His Arg 
1185                1190                1195                1200
Ser Thr Leu Thr Lys Lys Met His Ile Gln Ser Ala Val Ser Lys Met 
                1205                1210                1215    
Asn Pro Gly Glu Lys Glu Pro Ile His Arg Gly Thr Thr Glu Val Asn 
            1220                1225                1230        
Ile Asp Ser Glu Thr Val His Arg Met Leu Leu Ser Ala Pro Ser Glu 
        1235                1240                1245            
Asn Asp Arg Val Gln Lys Asn Leu Lys Asn Thr Ala Ala Glu Glu His 
    1250                1255                1260                
Val Ala Gln Gly Asp Ala Thr Leu Glu His Ser Thr Asn Leu Asp Ser 
1265                1270                1275                1280
Ser Pro Ser Leu Ser Ser Val Thr Val Val Pro Leu Arg Glu Ser Tyr 
                1285                1290                1295    
Asp Pro Asp Val Ile Pro Leu Phe Asp Lys Arg Thr Val Leu Glu Gly 
            1300                1305                1310        
Ser Thr Ala Ser Thr Ser Pro Ala Asp His Ser Ala Leu Pro Asn Gln 
        1315                1320                1325            
Ser Leu Thr Val Arg Glu Ser Glu Val Leu Lys Thr Ser Asp Ser Lys 
    1330                1335                1340                
Glu Gly Gly Glu Gly Phe Thr Val Asp Thr Pro Ala Lys Ala Ser Ile 
1345                1350                1355                1360
Thr Ser Lys Arg His Ile Pro Glu Ala His Gln Ala Thr Leu Leu Asp 
                1365                1370                1375    
Gly Lys Gln Gly Lys Val Ile Met Pro Leu Gly Ser Lys Leu Thr Gly 
            1380                1385                1390        
Val Ile Val Glu Asn Glu Asn Ile Thr Lys Glu Gly Gly Leu Val Asp 
        1395                1400                1405            
Met Ala Lys Lys Glu Asn Asp Leu Asn Ala Glu Pro Asn Leu Lys Gln 
    1410                1415                1420                
Thr Ile Lys Ala Thr Val Glu Asn Gly Lys Lys Asp Gly Ile Ala Val 
1425                1430                1435                1440
Asp His Val Val Gly Leu Asn Thr Glu Lys Tyr Ala Glu Thr Val Lys 
                1445                1450                1455    
Leu Lys His Lys Arg Ser Pro Gly Lys Val Lys Asp Ile Ser Ile Asp 
            1460                1465                1470        
Val Glu Arg Arg Asn Glu Asn Ser Glu Val Asp Thr Ser Ala Gly Ser 
        1475                1480                1485            
Gly Ser Ala Pro Ser Val Leu His Gln Arg Asn Gly Gln Thr Glu Asp 
    1490                1495                1500                
Val Ala Thr Gly Pro Arg Arg Ala Glu Lys Thr Ser Val Ala Thr Ser 
1505                1510                1515                1520
Thr Glu Gly Lys Asp Lys Asp Val Thr Leu Ser Pro Val Lys Ala Gly 
                1525                1530                1535    
Pro Ala Thr Thr Thr Ser Ser Glu Thr Arg Gln Ser Glu Val Ala Leu 
            1540                1545                1550        
Pro Cys Thr Ser Ile Glu Ala Asp Glu Gly Leu Ile Ile Gly Thr His 
        1555                1560                1565            
Ser Arg Asn Asn Pro Leu His Val Gly Ala Glu Ala Ser Glu Cys Thr 
    1570                1575                1580                
Val Phe Ala Ala Ala Glu Glu Gly Gly Ala Val Val Thr Glu Gly Phe 
1585                1590                1595                1600
Ala Glu Ser Glu Thr Phe Leu Thr Ser Thr Lys Glu Gly Glu Ser Gly 
                1605                1610                1615    
Glu Cys Ala Val Ala Glu Ser Glu Asp Arg Ala Ala Asp Leu Leu Ala 
            1620                1625                1630        
Val His Ala Val Lys Ile Glu Ala Asn Val Asn Ser Val Val Thr Glu 
        1635                1640                1645            
Glu Lys Asp Asp Ala Val Thr Ser Ala Gly Ser Glu Glu Lys Cys Asp 
    1650                1655                1660                
Gly Ser Leu Ser Arg Asp Ser Glu Ile Val Glu Gly Thr Ile Thr Phe 
1665                1670                1675                1680
Ile Ser Glu Val Glu Ser Asp Gly Ala Val Thr Ser Ala Gly Thr Glu 
                1685                1690                1695    
Ile Arg Ala Gly Ser Ile Ser Ser Glu Glu Val Asp Gly Ser Gln Gly 
            1700                1705                1710        
Asn Met Met Arg Met Gly Pro Lys Lys Glu Thr Glu Gly Thr Val Thr 
        1715                1720                1725            
Cys Thr Gly Ala Glu Gly Arg Ser Asp Asn Phe Val Ile Cys Ser Val 
    1730                1735                1740                
Thr Gly Ala Gly Pro Arg Glu Glu Arg Met Val Thr Gly Ala Gly Val 
1745                1750                1755                1760
Val Leu Gly Asp Asn Asp Ala Pro Pro Gly Thr Ser Ala Ser Gln Glu 
                1765                1770                1775    
Gly Asp Gly Ser Val Asn Asp Gly Thr Glu Gly Glu Ser Ala Val Thr 
            1780                1785                1790        
Ser Thr Gly Ile Thr Glu Asp Gly Glu Gly Pro Ala Ser Cys Thr Gly 
        1795                1800                1805            
Ser Glu Asp Ser Ser Glu Gly Phe Ala Ile Ser Ser Glu Ser Glu Glu 
    1810                1815                1820                
Asn Gly Glu Ser Ala Met Asp Ser Thr Val Ala Lys Glu Gly Thr Asn 
1825                1830                1835                1840
Val Pro Leu Val Ala Ala Gly Pro Cys Asp Asp Glu Gly Ile Val Thr 
                1845                1850                1855    
Ser Thr Gly Ala Lys Glu Glu Asp Glu Glu Gly Glu Asp Val Val Thr 
            1860                1865                1870        
Ser Thr Gly Arg Gly Asn Glu Ile Gly His Ala Ser Thr Cys Thr Gly 
        1875                1880                1885            
Leu Gly Glu Glu Ser Glu Gly Val Leu Ile Cys Glu Ser Ala Glu Gly 
    1890                1895                1900                
Asp Ser Gln Ile Gly Thr Val Val Glu His Val Glu Ala Glu Ala Gly 
1905                1910                1915                1920
Ala Ala Ile Met Asn Ala Asn Glu Asn Asn Val Asp Ser Met Ser Gly 
                1925                1930                1935    
Thr Glu Lys Gly Ser Lys Asp Thr Asp Ile Cys Ser Ser Ala Lys Gly 
            1940                1945                1950        
Ile Val Glu Ser Ser Val Thr Ser Ala Val Ser Gly Lys Asp Glu Val 
        1955                1960                1965            
Thr Pro Val Pro Gly Gly Cys Glu Gly Pro Met Thr Ser Ala Ala Ser 
    1970                1975                1980                
Asp Gln Ser Asp Ser Gln Leu Glu Lys Val Glu Asp Thr Thr Ile Ser 
1985                1990                1995                2000
Thr Gly Leu Val Gly Gly Ser Tyr Asp Val Leu Val Ser Gly Glu Val 
                2005                2010                2015    
Pro Glu Cys Glu Val Ala His Thr Ser Pro Ser Glu Lys Glu Asp Glu 
            2020                2025                2030        
Asp Ile Ile Thr Ser Val Glu Asn Glu Glu Cys Asp Gly Leu Met Ala 
        2035                2040                2045            
Thr Thr Ala Ser Gly Asp Ile Thr Asn Gln Asn Ser Leu Ala Gly Gly 
    2050                2055                2060                
Lys Asn Gln Gly Lys Val Leu Ile Ile Ser Thr Ser Thr Thr Asn Asp 
2065                2070                2075                2080
Tyr Thr Pro Gln Val Ser Ala Ile Thr Asp Val Glu Gly Gly Leu Ser 
                2085                2090                2095    
Asp Ala Leu Arg Thr Glu Glu Asn Met Glu Gly Thr Arg Val Thr Thr 
            2100                2105                2110        
Glu Glu Phe Glu Ala Pro Met Pro Ser Ala Val Ser Gly Asp Asp Ser 
        2115                2120                2125            
Gln Leu Thr Ala Ser Arg Ser Glu Glu Lys Asp Glu Cys Ala Met Ile 
    2130                2135                2140                
Ser Thr Ser Ile Gly Glu Glu Phe Glu Leu Pro Ile Ser Ser Ala Thr 
2145                2150                2155                2160
Thr Ile Lys Cys Ala Glu Ser Leu Gln Pro Val Ala Ala Ala Val Glu 
                2165                2170                2175    
Glu Arg Ala Thr Gly Pro Val Leu Ile Ser Thr Ala Asp Phe Glu Gly 
            2180                2185                2190        
Pro Met Pro Ser Ala Pro Pro Glu Ala Glu Ser Pro Leu Ala Ser Thr 
        2195                2200                2205            
Ser Lys Glu Glu Lys Asp Glu Cys Ala Leu Ile Ser Thr Ser Ile Ala 
    2210                2215                2220                
Glu Glu Cys Glu Ala Ser Val Ser Gly Val Val Val Glu Ser Glu Asn 
2225                2230                2235                2240
Glu Arg Ala Gly Thr Val Met Glu Glu Lys Asp Gly Ser Gly Ile Ile 
                2245                2250                2255    
Ser Thr Ser Ser Val Glu Asp Cys Glu Gly Pro Val Ser Ser Ala Val 
            2260                2265                2270        
Pro Gln Glu Glu Gly Asp Pro Ser Val Thr Pro Ala Glu Glu Met Gly 
        2275                2280                2285            
Asp Thr Ala Met Ile Ser Thr Ser Thr Ser Glu Gly Cys Glu Ala Val 
    2290                2295                2300                
Met Ile Gly Ala Val Leu Gln Asp Glu Asp Arg Leu Thr Ile Thr Arg 
2305                2310                2315                2320
Val Glu Asp Leu Ser Asp Ala Ala Ile Ile Ser Thr Ser Thr Ala Glu 
                2325                2330                2335    
Cys Met Pro Ile Ser Ala Ser Ile Asp Arg His Glu Glu Asn Gln Leu 
            2340                2345                2350        
Thr Ala Asp Asn Pro Glu Gly Asn Gly Asp Leu Ser Ala Thr Glu Val 
        2355                2360                2365            
Ser Lys His Lys Val Pro Met Pro Ser Leu Ile Ala Glu Asn Asn Cys 
    2370                2375                2380                
Arg Cys Pro Gly Pro Val Arg Gly Gly Lys Glu Pro Gly Pro Val Leu 
2385                2390                2395                2400
Ala Val Ser Thr Glu Glu Gly His Asn Gly Pro Ser Val His Lys Pro 
                2405                2410                2415    
Ser Ala Gly Gln Gly His Pro Ser Ala Val Cys Ala Glu Lys Glu Glu 
            2420                2425                2430        
Lys His Gly Lys Glu Cys Pro Glu Ile Gly Pro Phe Ala Gly Arg Gly 
        2435                2440                2445            
Gln Lys Glu Ser Thr Leu His Leu Ile Asn Ala Glu Glu Lys Asn Val 
    2450                2455                2460                
Leu Leu Asn Ser Leu Gln Lys Glu Asp Lys Ser Pro Glu Thr Gly Thr 
2465                2470                2475                2480
Ala Gly Gly Ser Ser Thr Ala Ser Tyr Ser Ala Gly Arg Gly Leu Glu 
                2485                2490                2495    
Gly Asn Ala Asn Ser Pro Ala His Leu Arg Gly Pro Glu Gln Thr Ser 
            2500                2505                2510        
Gly Gln Thr Ala Lys Asp Pro Ser Val Ser Ile Arg Tyr Leu Ala Ala 
        2515                2520                2525            
Val Asn Thr Gly Ala Ile Lys Ala Asp Asp Met Pro Pro Val Gln Gly 
    2530                2535                2540                
Thr Val Ala Glu His Ser Phe Leu Pro Ala Glu Gln Gln Gly Ser Glu 
2545                2550                2555                2560
Asp Asn Leu Lys Thr Ser Thr Thr Lys Cys Ile Thr Gly Gln Glu Ser 
                2565                2570                2575    
Lys Ile Ala Pro Ser His Thr Met Ile Pro Pro Ala Thr Tyr Ser Val 
            2580                2585                2590        
Ala Leu Leu Ala Pro Lys Cys Glu Gln Asp Leu Thr Ile Lys Asn Asp 
        2595                2600                2605            
Tyr Ser Gly Lys Trp Thr Asp Gln Ala Ser Ala Glu Lys Thr Gly Asp 
    2610                2615                2620                
Asp Asn Ser Thr Arg Lys Ser Phe Pro Glu Glu Gly Asp Ile Met Val 
2625                2630                2635                2640
Thr Val Ser Ser Glu Glu Asn Val Cys Asp Ile Gly Asn Glu Glu Ser 
                2645                2650                2655    
Pro Leu Asn Val Leu Gly Gly Leu Lys Leu Lys Ala Asn Leu Lys Met 
            2660                2665                2670        
Glu Ala Tyr Val Pro Ser Glu Glu Glu Lys Asn Gly Glu Ile Leu Ala 
        2675                2680                2685            
Pro Pro Glu Ser Leu Cys Gly Gly Lys Pro Ser Gly Ile Ala Glu Leu 
    2690                2695                2700                
Gln Arg Glu Pro Leu Leu Val Asn Glu Ser Leu Asn Val Glu Asn Ser 
2705                2710                2715                2720
Gly Phe Arg Thr Asn Glu Glu Ile His Ser Glu Ser Tyr Asn Lys Gly 
                2725                2730                2735    
Glu Ile Ser Ser Gly Arg Lys Asp Asn Ala Glu Ala Ile Ser Gly His 
            2740                2745                2750        
Ser Val Glu Ala Asp Pro Lys Glu Val Glu Glu Glu Glu Arg His Met 
        2755                2760                2765            
Pro Lys Arg Lys Arg Lys Gln His Tyr Leu Ser Ser Glu Asp Glu Pro 
    2770                2775                2780                
Asp Asp Asn Pro Asp Val Leu Asp Ser Arg Ile Glu Thr Ala Gln Arg 
2785                2790                2795                2800
Gln Cys Pro Glu Thr Glu Pro His Asp Thr Lys Glu Glu Asn Ser Arg 
                2805                2810                2815    
Asp Leu Glu Glu Leu Pro Lys Thr Ser Ser Glu Thr Asn Ser Thr Thr 
            2820                2825                2830        
Ser Arg Val Met Glu Glu Lys Asp Glu Tyr Ser Ser Ser Glu Thr Thr 
        2835                2840                2845            
Gly Glu Lys Pro Glu Gln Asn Asp Asp Asp Thr Ile Lys Ser Gln Glu 
    2850                2855                2860                
Glu Asp Gln Pro Ile Ile Ile Lys Arg Lys Arg Gly Arg Pro Arg Lys 
2865                2870                2875                2880
Tyr Pro Val Glu Thr Thr Leu Lys Met Lys Asp Asp Ser Lys Thr Asp 
                2885                2890                2895    
Thr Gly Ile Val Thr Val Glu Gln Ser Pro Ser Ser Ser Lys Leu Lys 
            2900                2905                2910        
Val Met Gln Thr Asp Glu Ser Asn Lys Glu Thr Ala Asn Leu Gln Glu 
        2915                2920                2925            
Arg Ser Ile Ser Asn Asp Asp Gly Glu Glu Lys Ile Val Thr Ser Val 
    2930                2935                2940                
Arg Arg Arg Gly Arg Lys Pro Lys Arg Ser Leu Thr Val Ser Asp Asp 
2945                2950                2955                2960
Ala Glu Ser Ser Glu Pro Glu Arg Lys Arg Gln Lys Ser Val Ser Asp 
                2965                2970                2975    
Pro Val Glu Asp Lys Lys Glu Gln Glu Ser Asp Glu Glu Glu Glu Glu 
            2980                2985                2990        
Glu Glu Glu Asp Glu Pro Ser Gly Ala Thr Thr Arg Ser Thr Thr Arg 
        2995                3000                3005            
Ser Glu Ala Gln Arg Ser Lys Thr Gln Leu Ser Pro Ser Ile Lys Arg 
    3010                3015                3020                
Lys Arg Glu Val Ser Pro Pro Gly Ala Arg Thr Arg Gly Gln Gln Arg 
3025                3030                3035                3040
Val Glu Glu Ala Pro Val Lys Lys Ala Lys Arg 
                3045                3050    

<210> 129
<211> 183
<212> PRT
<213> human

<400> 129
Met Ala His Gly Gly Pro Arg Gly Gln Leu Leu Gly Ala Asp Gly Gln 
1               5                   10                  15      
Glu Val Gln Pro Glu Ala Leu Met Gln Glu Leu Ser Arg Cys Gln Val 
            20                  25                  30          
Leu Gln Gly Arg Pro Lys Ile Phe Leu Leu Gln Ala Cys Arg Gly Gly 
        35                  40                  45              
Asn Arg Asp Ala Gly Val Gly Pro Thr Ala Leu Pro Trp Tyr Trp Ser 
    50                  55                  60                  
Trp Leu Arg Ala Pro Pro Ser Val Pro Ser His Ala Asp Val Leu Gln 
65                  70                  75                  80  
Ile Tyr Ala Glu Ala Gln Gly Ser Ser Cys Arg Gly Thr Pro Pro Gly 
                85                  90                  95      
Ser Ser Asp Gln Ala Asp Ile Leu Thr Val Tyr Ser Ala Ala Glu Gly 
            100                 105                 110         
Tyr Val Ala Tyr Arg Asp Asp Lys Gly Ser Asp Phe Ile Gln Thr Leu 
        115                 120                 125             
Val Glu Val Leu Arg Ala Asn Pro Gly Arg Asp Leu Leu Glu Leu Leu 
    130                 135                 140                 
Thr Glu Val Asn Arg Arg Val Cys Glu Gln Glu Val Leu Gly Pro Asp 
145                 150                 155                 160 
Cys Asp Glu Leu Arg Lys Ala Cys Leu Glu Ile Arg Ser Ser Leu Arg 
                165                 170                 175     
Arg Arg Leu Cys Leu Gln Ala 
            180             

<210> 130
<211> 84
<212> PRT
<213> human

<400> 130
Met Ser Tyr Tyr Gly Ser Tyr Tyr Arg Gly Leu Gly Tyr Gly Cys Gly 
1               5                   10                  15      
Gly Phe Gly Gly Leu Gly Tyr Gly Tyr Gly Cys Gly Cys Gly Ser Phe 
            20                  25                  30          
Arg Arg Leu Gly Tyr Gly Cys Gly Phe Gly Gly Asn Gly Tyr Gly Tyr 
        35                  40                  45              
Cys Arg Pro Ser Cys Tyr Gly Gly Tyr Gly Phe Ser Ile Leu Leu Lys 
    50                  55                  60                  
Ser Tyr Pro Glu Asp Thr Ile Ser Glu Val Ile Arg Arg Ser Phe Asn 
65                  70                  75                  80  
Leu Thr Lys Tyr 
                

<210> 131
<211> 148
<212> PRT
<213> human

<400> 131
Met Pro Gly Gly Asp Thr Thr Pro Glu Glu Ala Ala Ala Pro Ser Cys 
1               5                   10                  15      
Ala Gly Tyr Asn Pro Gly Leu Leu Leu Phe Arg Ala Gln Lys Ala Gln 
            20                  25                  30          
Gly Ala Cys Val Thr Ser Thr Glu Gly Ala Trp Pro Arg Arg Ala Ser 
        35                  40                  45              
Ala Leu Tyr Gly Gly Arg Lys Met Arg Cys Gly Glu Ser Gly Ala Gly 
    50                  55                  60                  
Pro Asp Pro Arg Ser Asn Ser Ala Glu Val Ser Ser Ser Gln Pro Ala 
65                  70                  75                  80  
Leu Ala Ser Lys Ser Gln Ser Lys Trp Gly Pro Thr Ser Asn Asn Pro 
                85                  90                  95      
Arg Gly Ala Leu Thr Thr Thr Glu Phe Glu Met Ala Gly Asn Arg Ser 
            100                 105                 110         
Gln Asn Ile Lys His Lys Gln Thr Ala Leu Ile Ala Ile Pro Met Ser 
        115                 120                 125             
Ser Gln Thr Pro Arg Met Leu Gly Arg Pro Arg Asn Gln Gly Gln Leu 
    130                 135                 140                 
Tyr Pro Gln Pro 
145             

<210> 132
<211> 293
<212> PRT
<213> human

<400> 132
Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Met Asn Ser 
1               5                   10                  15      
Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30          
Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Ala Gly Cys Ser Val 
        35                  40                  45              
His Lys Gly Phe Ala Phe Val Gln Tyr Asp Lys Glu Lys Asn Ala Arg 
    50                  55                  60                  
Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Ser Gln Val Val 
65                  70                  75                  80  
Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Asn Ala Gly 
                85                  90                  95      
Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Ser Phe Asp Leu Asp 
            100                 105                 110         
Tyr Gly Phe Gln Arg Asp Tyr Tyr Asp Gly Met Tyr Ser Phe Pro Ala 
        115                 120                 125             
Arg Val Pro Pro Pro Pro Pro Ile Ala Leu Ala Val Val Pro Ser Lys 
    130                 135                 140                 
Arg Gln Arg Leu Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe 
145                 150                 155                 160 
Asn Ser Lys Ser Gly Lys Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys 
                165                 170                 175     
Gly Asp Asp Leu Gln Ala Ile Lys Gln Glu Leu Thr Gln Ile Lys Gln 
            180                 185                 190         
Lys Val Asp Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln 
        195                 200                 205             
Ser Lys Gln Glu Val Glu Val Lys Asn Ala Lys Ser Glu Glu Glu Gln 
    210                 215                 220                 
Ser Ser Ser Ser Met Lys Lys Asp Glu Thr His Val Lys Met Glu Ser 
225                 230                 235                 240 
Glu Gly Gly Ala Glu Asp Ser Ala Glu Glu Gly Asp Pro Leu Asp Asp 
                245                 250                 255     
Asp Val Asn Glu Asp Gln Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp 
            260                 265                 270         
Asp Glu Lys Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Thr Asn 
        275                 280                 285             
Gly Gln Asp Asp Ser 
    290             

<210> 133
<211> 244
<212> PRT
<213> human

<400> 133
Met Gly Asp Leu Phe Ser Leu Phe Trp Glu Val Asp Pro Pro Pro Ile 
1               5                   10                  15      
Pro Val Asn Cys Ala Ile Pro Asn Gln Asp Tyr Glu Cys Trp Lys Asp 
            20                  25                  30          
Asp Ser Cys Gly Thr Ile Gly Ser Phe Leu Leu Trp Tyr Phe Val Ile 
        35                  40                  45              
Val Phe Val Leu Met Phe Phe Ser Arg Ala Ser Val Trp Met Ser Glu 
    50                  55                  60                  
Asp Lys Lys Asp Glu Gly Ser Gly Thr Ser Thr Ser Val Arg Lys Ala 
65                  70                  75                  80  
Ser Lys Glu Thr Ser Cys Lys Arg Gln Ser Lys Asp Ser Ala Trp Asp 
                85                  90                  95      
Pro Ser Gln Thr Met Lys Lys Pro Lys Gln Asn Gln Leu Thr Pro Val 
            100                 105                 110         
Thr Asn Ser Glu Val Ala Leu Val Asn Ala Tyr Pro Glu Gln Arg Arg 
        115                 120                 125             
Ala Arg Arg Gln Ser Gln Phe Asn Glu Val Asn Gln Asn Gln His Asp 
    130                 135                 140                 
Ser Asp Thr Thr Glu Tyr Gly Ser Glu Glu Ser Asn Ser Glu Ala Ser 
145                 150                 155                 160 
Ser Trp Lys Glu Ser Glu Ser Glu His His Pro Ser Pro Asp Ser Ile 
                165                 170                 175     
Lys Arg Arg Lys Met Ala Gln Arg Gln Arg Asn Leu Gly Ser Tyr Gln 
            180                 185                 190         
Met Ser Glu Arg His Cys Leu His Cys Lys Ala Leu Arg Thr Asn Glu 
        195                 200                 205             
Trp Leu Ala His His Ser Arg Gln Lys Pro Ser Val Thr Pro Pro Met 
    210                 215                 220                 
Lys Arg Asp Ser Gln Glu Glu Ser Ser Ile Ser Asp Ile Asn Lys Lys 
225                 230                 235                 240 
Phe Ser Lys Phe 
                

<210> 134
<211> 136
<212> PRT
<213> human

<400> 134
Met Asn Cys Asp Ala Leu Leu His His Ser Ala Ile Pro Glu Asp Phe 
1               5                   10                  15      
Leu His Ile Phe Leu Leu Leu Gln Lys Ile Ser Val Ser Leu Pro Leu 
            20                  25                  30          
Ser Leu Ser Gln Ser Val Cys Leu Phe Tyr Ser Ile Ser Leu Cys Val 
        35                  40                  45              
Ser Leu Leu Leu His Ile Ser Leu Cys Val Ser Val Tyr Val Ser Leu 
    50                  55                  60                  
Ser Leu Ser Ser Phe Pro Cys Phe Ser Leu Thr His Thr His Thr His 
65                  70                  75                  80  
Ser Gln Leu Ser Lys Asp Thr Ser Val Leu Thr Phe Thr Phe Cys Phe 
                85                  90                  95      
Lys Gln His Thr His Phe Thr Leu Asn Tyr Thr Ser His Ala His Glu 
            100                 105                 110         
Leu Ser Ala Pro Ser Val His Pro Thr Cys Val Phe Thr Phe Lys Ala 
        115                 120                 125             
Ala Pro Ser Pro Arg Pro Ala Thr 
    130                 135     

<210> 135
<211> 148
<212> PRT
<213> human

<400> 135
Met Gly Ser Gln Gly Ser Gly Gly Val Pro Leu Val Gln Ala Pro Tyr 
1               5                   10                  15      
Thr Val Leu Leu Leu Pro Leu Gly Thr Ser Arg Gln Asp Pro Gly Ala 
            20                  25                  30          
Gln Ser Phe Phe Leu Trp Leu Arg Arg Met Gln Ala Leu Glu Arg Glu 
        35                  40                  45              
Gln Asp Ala Leu Trp Gln Gly Leu Glu Leu Leu Gln His Gly Gln Ala 
    50                  55                  60                  
Trp Phe Glu Asp His Leu Arg Glu Ala Gln Arg Gln Gln Leu His Leu 
65                  70                  75                  80  
Gly Ala Leu Gly Glu Asn Phe Leu Thr Asp Leu His Ser Glu Pro Gly 
                85                  90                  95      
Arg Pro Pro Leu Ala Gln Ile Gln Lys Val Asn Ile Cys Leu Gln Asn 
            100                 105                 110         
Leu Ile His Glu Lys Glu Leu Ser Arg Gln Gln Lys Gly Val Thr Gln 
        115                 120                 125             
Pro Lys Glu Glu Met Ala Gln Arg Gly Cys Thr Lys Gly Pro Arg Gly 
    130                 135                 140                 
Pro Thr Arg Val 
145             

<210> 136
<211> 309
<212> PRT
<213> human

<400> 136
Met Lys Arg Lys Asn Phe Thr Glu Val Ser Glu Phe Ile Phe Leu Gly 
1               5                   10                  15      
Phe Ser Ser Phe Gly Lys His Gln Ile Thr Leu Phe Val Val Phe Leu 
            20                  25                  30          
Thr Val Tyr Ile Leu Thr Leu Val Ala Asn Ile Ile Ile Val Thr Ile 
        35                  40                  45              
Ile Cys Ile Asp His His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  
Met Leu Ala Ser Ser Glu Thr Val Tyr Thr Leu Val Ile Val Pro Arg 
65                  70                  75                  80  
Met Leu Leu Ser Leu Ile Phe His Asn Gln Pro Ile Ser Leu Ala Gly 
                85                  90                  95      
Cys Ala Thr Gln Met Phe Phe Phe Val Ile Leu Ala Thr Asn Asn Cys 
            100                 105                 110         
Phe Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Arg 
        115                 120                 125             
Pro Leu Arg Tyr Thr Val Ile Met Ser Lys Gly Leu Cys Ala Gln Leu 
    130                 135                 140                 
Val Cys Gly Ser Phe Gly Ile Gly Leu Thr Met Ala Val Leu His Val 
145                 150                 155                 160 
Thr Ala Met Phe Asn Leu Pro Phe Cys Gly Thr Val Val Asp His Phe 
                165                 170                 175     
Phe Cys Asp Ile Tyr Pro Val Met Lys Leu Ser Cys Ile Asp Thr Thr 
            180                 185                 190         
Ile Asn Glu Ile Ile Asn Tyr Gly Val Ser Ser Phe Val Ile Phe Val 
        195                 200                 205             
Pro Ile Gly Leu Ile Phe Ile Ser Tyr Val Leu Val Ile Ser Ser Ile 
    210                 215                 220                 
Leu Gln Ile Ala Ser Ala Glu Gly Arg Lys Lys Thr Phe Ala Thr Cys 
225                 230                 235                 240 
Val Ser His Leu Thr Val Val Ile Val His Cys Gly Cys Ala Ser Ile 
                245                 250                 255     
Ala Tyr Leu Lys Pro Lys Ser Glu Ser Ser Ile Glu Lys Asp Leu Val 
            260                 265                 270         
Leu Ser Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Val Val 
        275                 280                 285             
Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Cys Arg Val Val 
    290                 295                 300                 
Gly Arg Asn Ile Ser 
305                 

<210> 137
<211> 123
<212> PRT
<213> human

<400> 137
Met Asn Gly Ser Asn Met Ala Asn Thr Ser Pro Ser Val Lys Ser Lys 
1               5                   10                  15      
Glu Asp Gln Gly Leu Ser Gly His Asp Glu Lys Glu Asn Pro Phe Ala 
            20                  25                  30          
Glu Tyr Met Trp Met Glu Asn Glu Glu Asp Phe Asn Arg Gln Val Glu 
        35                  40                  45              
Glu Glu Leu Gln Glu Gln Asp Phe Leu Asp Arg Cys Phe Gln Glu Met 
    50                  55                  60                  
Leu Asp Glu Glu Asp Gln Asp Trp Phe Ile Pro Ser Arg Asp Leu Pro 
65                  70                  75                  80  
Gln Ala Met Gly Gln Leu Gln Gln Gln Leu Asn Gly Leu Ser Val Ser 
                85                  90                  95      
Glu Gly His Asp Ser Glu Asp Ile Leu Ser Lys Ser Asn Leu Asn Pro 
            100                 105                 110         
Asp Ala Lys Glu Phe Ile Pro Gly Glu Lys Tyr 
        115                 120             

<210> 138
<211> 73
<212> PRT
<213> human

<400> 138
Met Gln Phe Ala Asp Trp Leu His Pro Ser Gly Trp Thr Ile Glu Ile 
1               5                   10                  15      
Leu Asn Ala Tyr Gly Met Gly Asp Arg Lys Arg Thr Asn Ser Met Ser 
            20                  25                  30          
Lys Glu Ala Phe Thr Pro Glu Gln Leu His Leu Glu Lys Glu Leu Gly 
        35                  40                  45              
Glu Met Arg Leu Arg Pro Thr Val Leu His Ser Gln Thr Asp His Gln 
    50                  55                  60                  
Gly Phe Arg Pro Ile Pro Met Met Gln 
65                  70              

<210> 139
<211> 72
<212> PRT
<213> human

<400> 139
Met Asn Tyr Tyr Gly Asn Tyr Tyr Gly Gly Leu Gly Tyr Gly Tyr Gly 
1               5                   10                  15      
Gly Phe Asp Asp Leu Gly Tyr Gly Tyr Gly Cys Gly Cys Gly Ser Phe 
            20                  25                  30          
Arg Arg Leu Gly Tyr Gly Gly Gly Tyr Gly Gly Tyr Gly Tyr Gly Ser 
        35                  40                  45              
Gly Phe Gly Gly Tyr Gly Tyr Arg Ser Cys Arg Pro Ser Cys Tyr Gly 
    50                  55                  60                  
Gly Tyr Gly Phe Ser Gly Phe Tyr 
65                  70          

<210> 140
<211> 321
<212> PRT
<213> human

<400> 140
Met His Gly Arg Ala Tyr Leu Leu Leu His Arg Asp Phe Cys Asp Leu 
1               5                   10                  15      
Lys Glu Asn Asn Tyr Lys Gly Ile Thr Ala Lys Pro Val Ser Glu Asp 
            20                  25                  30          
Met Met Glu Trp Glu Val Glu Ile Glu Gly Leu Gln Asn Ser Val Trp 
        35                  40                  45              
Gln Gly Leu Val Phe Gln Leu Thr Ile His Phe Thr Ser Glu Tyr Asn 
    50                  55                  60                  
Tyr Ala Pro Pro Val Val Lys Phe Ile Thr Ile Pro Phe His Pro Asn 
65                  70                  75                  80  
Val Asp Pro His Thr Gly Gln Pro Cys Ile Asp Phe Leu Asp Asn Pro 
                85                  90                  95      
Glu Lys Trp Asn Thr Asn Tyr Thr Leu Ser Ser Ile Leu Leu Ala Leu 
            100                 105                 110         
Gln Val Met Leu Ser Asn Pro Val Leu Glu Asn Pro Val Asn Leu Glu 
        115                 120                 125             
Ala Ala Arg Ile Leu Val Lys Asp Glu Ser Leu Tyr Arg Thr Ile Leu 
    130                 135                 140                 
Arg Leu Phe Asn Arg Pro Leu Gln Met Lys Asp Asp Ser Gln Glu Leu 
145                 150                 155                 160 
Pro Lys Asp Pro Arg Lys Cys Ile Arg Pro Ile Lys Thr Thr Ser Phe 
                165                 170                 175     
Ser Asp Tyr Tyr Gln Thr Trp Ser Arg Ile Ala Thr Ser Lys Ala Thr 
            180                 185                 190         
Glu Tyr Tyr Arg Thr Pro Leu Leu Lys Val Pro Asn Phe Ile Gly Gln 
        195                 200                 205             
Tyr Tyr Lys Trp Lys Lys Met Asp Leu Gln His Gln Lys Glu Trp Asn 
    210                 215                 220                 
Leu Lys Tyr Ser Val Ile Lys Cys Trp Leu Ala Arg Lys Arg Met Pro 
225                 230                 235                 240 
His Glu Val Thr His Ser Met Glu Glu Ile Lys Leu Cys Pro Thr Leu 
                245                 250                 255     
Ile Pro Thr Thr Asp Glu Ile Phe Leu Glu Ser Pro Thr Ala Ile Asn 
            260                 265                 270         
Ser Ile Thr Asp Ile Tyr Glu Thr Glu Glu Glu Gly Trp Lys Ser Asp 
        275                 280                 285             
Thr Ser Leu Tyr Glu Asn Asp Thr Asp Glu Pro Arg Glu Glu Glu Val 
    290                 295                 300                 
Glu Asp Leu Ile Ser Trp Thr Asn Thr Leu Asn Thr Asn Thr Ser Glu 
305                 310                 315                 320 
Asp 
    

<210> 141
<211> 62
<212> PRT
<213> human

<400> 141
Met Gly Glu Leu Ala Ala Ser Ala Asn His Gly His Ser Pro Cys Tyr 
1               5                   10                  15      
Pro Glu Arg Lys Gly Thr Pro Gly Asp Leu Ser Lys Arg Lys Met Leu 
            20                  25                  30          
Val His Phe Tyr Pro Arg Arg His Ser His Pro Arg Ala Thr Gln Gln 
        35                  40                  45              
Trp Ile Leu Lys Asn Lys Thr Leu Cys Arg Arg Ile Lys Glu 
    50                  55                  60          

<210> 142
<211> 188
<212> PRT
<213> human

<400> 142
Met Phe Ser Cys Cys Phe Pro Thr Ser Arg Gly Cys Cys Phe Arg Asn 
1               5                   10                  15      
Gly Gly Ser Glu Ser Leu Phe Arg Arg Cys Arg Arg Arg Leu Ile Pro 
            20                  25                  30          
His Pro Arg Arg Leu Ser Pro Val Val Ile Arg Arg Ile Gln Val Pro 
        35                  40                  45              
Gln Asp Ser Leu Gly Gln Ala Leu Ala Gly Gln Ala Thr Pro Glu Ile 
    50                  55                  60                  
Pro Leu Gly Leu Gln Leu His Thr Val Leu Val Gln Glu Ile Gln Glu 
65                  70                  75                  80  
Leu Ile Glu Ala Gln Thr Leu Ala Pro Gly Pro Cys Ala Glu Val Arg 
                85                  90                  95      
Ala Leu Pro Ala Pro Ala Ala Glu Pro Glu Pro Ala Trp Glu Glu Ala 
            100                 105                 110         
Pro Pro Glu Arg Ala Leu Glu Leu Glu Gly Ala Pro Ala Lys Asp Gln 
        115                 120                 125             
Thr Asn Glu Glu Leu Pro Glu Ile Thr Glu Val Pro Glu Ser Ile Lys 
    130                 135                 140                 
Arg Arg Leu Gly Arg Arg Val Pro Ala Ala Thr Pro Ala Pro Arg Gly 
145                 150                 155                 160 
Asn Leu Leu Leu Gln Ala Trp Met Arg Val His Ser Trp Ala Ser Arg 
                165                 170                 175     
Leu Phe Ala Pro Asn Val Leu Pro Gly Thr Gly Pro 
            180                 185             

<210> 143
<211> 262
<212> PRT
<213> human

<400> 143
Met Thr Gln Pro Val Pro Arg Leu Ser Val Pro Ala Ala Leu Ala Leu 
1               5                   10                  15      
Gly Ser Ala Ala Leu Gly Ala Ala Phe Ala Thr Gly Leu Phe Leu Gly 
            20                  25                  30          
Arg Arg Cys Pro Pro Trp Arg Gly Arg Arg Glu Gln Cys Leu Leu Pro 
        35                  40                  45              
Pro Glu Asp Ser Arg Leu Trp Gln Tyr Leu Leu Ser Arg Ser Met Arg 
    50                  55                  60                  
Glu His Pro Ala Leu Arg Ser Leu Arg Leu Leu Thr Leu Glu Gln Pro 
65                  70                  75                  80  
Gln Gly Asp Ser Met Met Thr Cys Glu Gln Ala Gln Leu Leu Ala Asn 
                85                  90                  95      
Leu Ala Arg Leu Ile Gln Ala Lys Lys Ala Leu Asp Leu Gly Thr Phe 
            100                 105                 110         
Thr Gly Tyr Ser Ala Leu Ala Leu Ala Leu Ala Leu Pro Ala Asp Gly 
        115                 120                 125             
Arg Val Val Thr Cys Glu Val Asp Ala Gln Pro Pro Glu Leu Gly Arg 
    130                 135                 140                 
Pro Leu Trp Arg Gln Ala Glu Ala Glu His Lys Ile Asp Leu Arg Leu 
145                 150                 155                 160 
Lys Pro Ala Leu Glu Thr Leu Asp Glu Leu Leu Ala Ala Gly Glu Ala 
                165                 170                 175     
Gly Thr Phe Asp Val Ala Val Val Asp Ala Asp Lys Glu Asn Cys Ser 
            180                 185                 190         
Ala Tyr Tyr Glu Arg Cys Leu Gln Leu Leu Arg Pro Gly Gly Ile Leu 
        195                 200                 205             
Ala Val Leu Arg Val Leu Trp Arg Gly Lys Val Leu Gln Pro Pro Lys 
    210                 215                 220                 
Gly Asp Val Ala Ala Glu Cys Val Arg Asn Leu Asn Glu Arg Ile Arg 
225                 230                 235                 240 
Arg Asp Val Arg Val Tyr Ile Ser Leu Leu Pro Leu Gly Asp Gly Leu 
                245                 250                 255     
Thr Leu Ala Phe Lys Ile 
            260         

<210> 144
<211> 344
<212> PRT
<213> human

<400> 144
Met Glu Ala Ala Arg Pro Phe Ala Arg Glu Trp Arg Ala Gln Ser Leu 
1               5                   10                  15      
Pro Leu Ala Val Gly Gly Val Leu Lys Leu Arg Leu Cys Glu Leu Trp 
            20                  25                  30          
Leu Leu Leu Leu Gly Ser Ser Leu Asn Ala Arg Phe Leu Pro Asp Glu 
        35                  40                  45              
Glu Asp Val Asp Phe Ile Asn Glu Tyr Val Asn Leu His Asn Glu Leu 
    50                  55                  60                  
Arg Gly Asp Val Ile Pro Arg Gly Ser Asn Leu Arg Phe Met Thr Trp 
65                  70                  75                  80  
Asp Val Ala Leu Ser Arg Thr Ala Arg Ala Trp Gly Lys Lys Cys Leu 
                85                  90                  95      
Phe Thr His Asn Ile Tyr Leu Gln Asp Val Gln Met Val His Pro Lys 
            100                 105                 110         
Phe Tyr Gly Ile Gly Glu Asn Met Trp Val Gly Pro Glu Asn Glu Phe 
        115                 120                 125             
Thr Ala Ser Ile Ala Ile Arg Ser Trp His Ala Glu Lys Lys Met Tyr 
    130                 135                 140                 
Asn Phe Glu Asn Gly Ser Cys Ser Gly Asp Cys Ser Asn Tyr Ile Gln 
145                 150                 155                 160 
Leu Val Trp Asp His Ser Tyr Lys Val Gly Cys Ala Val Thr Pro Cys 
                165                 170                 175     
Ser Lys Ile Gly His Ile Ile His Ala Ala Ile Phe Ile Cys Asn Tyr 
            180                 185                 190         
Ala Pro Gly Gly Thr Leu Thr Arg Arg Pro Tyr Glu Pro Gly Ile Phe 
        195                 200                 205             
Cys Thr Arg Cys Gly Arg Arg Asp Lys Cys Thr Asp Phe Leu Cys Ser 
    210                 215                 220                 
Asn Ala Asp Arg Asp Gln Ala Thr Tyr Tyr Arg Phe Trp Tyr Pro Lys 
225                 230                 235                 240 
Trp Glu Met Pro Arg Pro Val Val Cys Asp Pro Leu Cys Thr Phe Ile 
                245                 250                 255     
Leu Leu Leu Arg Ile Leu Cys Phe Ile Leu Cys Val Ile Thr Val Leu 
            260                 265                 270         
Ile Val Gln Ser Gln Phe Pro Asn Ile Leu Leu Glu Gln Gln Met Ile 
        275                 280                 285             
Phe Thr Pro Glu Glu Ser Glu Ala Gly Asn Glu Glu Glu Glu Lys Glu 
    290                 295                 300                 
Glu Glu Lys Lys Glu Lys Glu Glu Met Glu Met Glu Ile Met Glu Met 
305                 310                 315                 320 
Glu Glu Glu Lys Glu Glu Arg Glu Glu Glu Glu Glu Glu Thr Gln Lys 
                325                 330                 335     
Glu Lys Met Glu Glu Glu Glu Lys 
            340                 

<210> 145
<211> 2896
<212> PRT
<213> human

<400> 145
Met Ser Glu Lys Ser Gly Gln Ser Thr Lys Ala Lys Asp Gly Lys Lys 
1               5                   10                  15      
Tyr Ala Thr Leu Ser Leu Phe Asn Thr Tyr Lys Gly Lys Ser Leu Glu 
            20                  25                  30          
Thr Gln Lys Thr Thr Ala Arg His Gly Leu Gln Ser Leu Gly Lys Val 
        35                  40                  45              
Gly Ile Ser Arg Arg Met Pro Pro Pro Ala Asn Leu Pro Ser Leu Lys 
    50                  55                  60                  
Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Asn Ile Val Pro Lys Asp 
65                  70                  75                  80  
Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln His Glu Glu Glu Lys Thr 
                85                  90                  95      
Pro Glu Val Pro Pro Ala Gln Pro Lys Pro Gly Val Ala Ala Pro Pro 
            100                 105                 110         
Glu Val Ala Pro Ala Pro Lys Ser Trp Ala Ser Asn Lys Gln Gly Gly 
        115                 120                 125             
Gln Gly Asp Gly Ile Gln Val Asn Ser Gln Phe Gln Gln Glu Phe Pro 
    130                 135                 140                 
Ser Leu Gln Ala Ala Gly Asp Gln Glu Lys Lys Glu Lys Glu Thr Asn 
145                 150                 155                 160 
Asp Asp Asn Tyr Gly Pro Gly Pro Ser Leu Arg Pro Pro Asn Val Ala 
                165                 170                 175     
Cys Trp Arg Asp Gly Gly Lys Ala Ala Gly Ser Pro Ser Ser Ser Asp 
            180                 185                 190         
Gln Asp Glu Lys Leu Pro Gly Gln Asp Glu Ser Thr Ala Gly Thr Ser 
        195                 200                 205             
Glu Gln Asn Asp Ile Leu Lys Val Val Glu Lys Arg Ile Ala Cys Gly 
    210                 215                 220                 
Pro Pro Gln Ala Lys Leu Asn Gly Gln Gln Ala Ala Leu Ala Ser Gln 
225                 230                 235                 240 
Tyr Arg Ala Met Met Pro Pro Tyr Met Phe Gln Gln Tyr Pro Arg Met 
                245                 250                 255     
Thr Tyr Pro Pro Leu His Gly Pro Met Arg Phe Pro Pro Ser Leu Ser 
            260                 265                 270         
Glu Thr Asn Lys Gly Leu Arg Gly Arg Gly Pro Pro Pro Ser Trp Ala 
        275                 280                 285             
Ser Glu Pro Glu Arg Pro Ser Ile Leu Ser Ala Ser Glu Leu Lys Glu 
    290                 295                 300                 
Leu Asp Lys Phe Asp Asn Leu Asp Ala Glu Ala Asp Glu Gly Trp Ala 
305                 310                 315                 320 
Gly Ala Gln Met Glu Val Asp Tyr Thr Glu Gln Leu Asn Phe Ser Asp 
                325                 330                 335     
Asp Asp Glu Gln Gly Ser Asn Ser Pro Lys Glu Asn Asn Ser Glu Asp 
            340                 345                 350         
Gln Gly Ser Lys Ala Ser Glu Asn Asn Glu Asn Lys Lys Glu Thr Asp 
        355                 360                 365             
Glu Val Ser Asn Thr Lys Ser Ser Ser Gln Ile Pro Ala Gln Pro Ser 
    370                 375                 380                 
Val Ala Lys Val Pro Tyr Gly Lys Gly Pro Ser Phe Asn Gln Glu Arg 
385                 390                 395                 400 
Gly Thr Ser Ser His Leu Pro Pro Pro Pro Lys Leu Leu Ala Gln Gln 
                405                 410                 415     
His Pro Pro Pro Asp Arg Gln Ala Val Pro Gly Arg Pro Gly Pro Phe 
            420                 425                 430         
Pro Ser Lys Gln Gln Val Ala Asp Glu Asp Glu Ile Trp Lys Gln Arg 
        435                 440                 445             
Arg Arg Gln Gln Ser Glu Ile Ser Ala Ala Val Glu Arg Ala Arg Lys 
    450                 455                 460                 
Arg Arg Glu Glu Glu Glu Arg Arg Met Glu Glu Gln Arg Lys Ala Ala 
465                 470                 475                 480 
Cys Ala Glu Lys Leu Lys Arg Leu Asp Glu Lys Leu Gly Ile Leu Glu 
                485                 490                 495     
Lys Gln Pro Ser Pro Glu Glu Ile Arg Glu Arg Glu Arg Glu Lys Glu 
            500                 505                 510         
Arg Glu Arg Glu Lys Glu Leu Glu Lys Glu Gln Glu Gln Glu Arg Glu 
        515                 520                 525             
Lys Glu Arg Glu Lys Asp Arg Glu Arg Gln Gln Glu Lys Glu Lys Glu 
    530                 535                 540                 
Leu Glu Lys Glu Gln Glu Lys Gln Arg Glu Met Glu Lys Glu Arg Lys 
545                 550                 555                 560 
Gln Glu Lys Glu Lys Glu Leu Glu Arg Gln Lys Glu Lys Glu Lys Glu 
                565                 570                 575     
Leu Gln Lys Met Lys Glu Gln Glu Lys Glu Cys Glu Leu Glu Lys Glu 
            580                 585                 590         
Arg Glu Lys Leu Glu Glu Lys Ile Glu Pro Arg Glu Pro Asn Leu Glu 
        595                 600                 605             
Pro Met Val Glu Lys Gln Glu Ser Glu Asn Ser Cys Asn Lys Glu Glu 
    610                 615                 620                 
Glu Pro Val Phe Thr Arg Gln Asp Ser Asn Arg Ser Glu Lys Glu Ala 
625                 630                 635                 640 
Thr Pro Val Val His Glu Thr Glu Pro Glu Ser Gly Ser Gln Pro Arg 
                645                 650                 655     
Pro Ala Val Leu Ser Gly Tyr Phe Lys Gln Phe Gln Lys Ser Leu Pro 
            660                 665                 670         
Pro Arg Phe Gln Arg Gln Gln Glu Gln Met Lys Gln Gln Gln Trp Gln 
        675                 680                 685             
Gln Gln Gln Gln Gln Gly Val Leu Pro Gln Thr Val Pro Ser Gln Pro 
    690                 695                 700                 
Ser Ser Ser Thr Val Pro Pro Pro Pro His Arg Pro Leu Tyr Gln Pro 
705                 710                 715                 720 
Met Gln Pro His Pro Gln His Leu Ala Ser Met Gly Phe Asp Pro Arg 
                725                 730                 735     
Trp Leu Met Met Gln Ser Tyr Met Asp Pro Arg Met Met Ser Gly Arg 
            740                 745                 750         
Pro Ala Met Asp Ile Pro Pro Ile His Pro Gly Met Ile Pro Pro Lys 
        755                 760                 765             
Pro Leu Met Arg Arg Asp Gln Met Glu Gly Ser Pro Asn Ser Ser Glu 
    770                 775                 780                 
Ser Phe Glu His Ile Ala Arg Ser Ala Arg Asp His Ala Ile Ser Leu 
785                 790                 795                 800 
Ser Glu Pro Arg Met Leu Trp Gly Ser Asp Pro Tyr Pro His Ala Glu 
                805                 810                 815     
Pro Gln Gln Ala Thr Thr Pro Lys Ala Thr Glu Glu Pro Glu Asp Val 
            820                 825                 830         
Arg Ser Glu Ala Ala Leu Asp Gln Glu Gln Ile Thr Ala Ala Tyr Ser 
        835                 840                 845             
Val Glu His Asn Gln Leu Glu Ala His Pro Lys Ala Asp Phe Ile Arg 
    850                 855                 860                 
Glu Ser Ser Glu Ala Gln Val Gln Lys Phe Leu Ser Arg Ser Val Glu 
865                 870                 875                 880 
Asp Val Arg Pro His His Thr Asp Ala Asn Asn Gln Ser Ala Cys Phe 
                885                 890                 895     
Glu Ala Pro Asp Gln Lys Thr Leu Ser Ala Pro Gln Glu Glu Arg Ile 
            900                 905                 910         
Ser Ala Val Glu Ser Gln Pro Ser Arg Lys Arg Ser Val Ser His Gly 
        915                 920                 925             
Ser Asn His Thr Gln Lys Pro Asp Glu Gln Arg Ser Glu Pro Ser Ala 
    930                 935                 940                 
Gly Ile Pro Lys Val Thr Ser Arg Cys Ile Asp Ser Lys Glu Pro Ile 
945                 950                 955                 960 
Glu Arg Pro Glu Glu Lys Pro Lys Lys Glu Gly Phe Ile Arg Ser Ser 
                965                 970                 975     
Glu Gly Pro Lys Pro Glu Lys Val Tyr Lys Ser Lys Ser Glu Thr Arg 
            980                 985                 990         
Trp Gly Pro Arg Pro Ser Ser Asn Arg Arg Glu Glu Val Asn Asp Arg 
        995                 1000                1005            
Pro Val Arg Arg Ser Gly Pro Ile Lys Lys Pro Val Leu Arg Asp Met 
    1010                1015                1020                
Lys Glu Glu Arg Glu Gln Arg Lys Glu Lys Glu Gly Glu Lys Ala Glu 
1025                1030                1035                1040
Lys Val Thr Glu Lys Val Val Val Lys Pro Glu Lys Thr Glu Lys Lys 
                1045                1050                1055    
Asp Leu Pro Pro Pro Pro Pro Pro Pro Gln Pro Pro Ala Pro Ile Gln 
            1060                1065                1070        
Pro Gln Ser Val Pro Pro Pro Ile Gln Pro Glu Ala Glu Lys Phe Pro 
        1075                1080                1085            
Ser Thr Glu Thr Ala Thr Leu Ala Gln Lys Pro Ser Gln Asp Thr Glu 
    1090                1095                1100                
Lys Pro Leu Glu Pro Val Ser Thr Val Gln Val Glu Pro Ala Val Lys 
1105                1110                1115                1120
Thr Val Asn Gln Gln Thr Met Ala Ala Pro Val Val Lys Glu Glu Lys 
                1125                1130                1135    
Gln Pro Glu Lys Val Ile Ser Lys Asp Leu Val Ile Glu Arg Pro Arg 
            1140                1145                1150        
Pro Asp Ser Arg Pro Ala Val Lys Lys Glu Ser Thr Leu Pro Pro Arg 
        1155                1160                1165            
Thr Tyr Trp Lys Glu Ala Arg Glu Arg Asp Trp Phe Pro Asp Gln Gly 
    1170                1175                1180                
Tyr Arg Gly Arg Gly Arg Gly Glu Tyr Tyr Ser Arg Gly Arg Ser Tyr 
1185                1190                1195                1200
Arg Gly Ser Tyr Gly Gly Arg Gly Arg Gly Gly Arg Gly His Thr Arg 
                1205                1210                1215    
Asp Tyr Pro Gln Tyr Arg Asp Asn Lys Pro Arg Ala Glu His Ile Pro 
            1220                1225                1230        
Ser Gly Pro Leu Arg Gln Arg Glu Glu Ser Glu Thr Arg Ser Glu Ser 
        1235                1240                1245            
Ser Asp Phe Glu Val Val Pro Lys Arg Arg Arg Gln Arg Gly Ser Glu 
    1250                1255                1260                
Thr Asp Thr Asp Ser Glu Ile His Glu Ser Ala Ser Asp Lys Asp Ser 
1265                1270                1275                1280
Leu Ser Lys Gly Lys Leu Pro Lys Arg Glu Glu Arg Pro Glu Asn Lys 
                1285                1290                1295    
Lys Pro Val Lys Pro His Ser Ser Phe Lys Pro Asp Asn His Val Arg 
            1300                1305                1310        
Ile Asp Asn Arg Leu Leu Glu Lys Pro Tyr Val Arg Asp Asp Asp Lys 
        1315                1320                1325            
Ala Lys Pro Gly Phe Leu Pro Lys Gly Glu Pro Thr Arg Arg Gly Arg 
    1330                1335                1340                
Gly Gly Thr Phe Arg Arg Gly Gly Arg Asp Pro Gly Gly Arg Pro Ser 
1345                1350                1355                1360
Arg Pro Ser Thr Leu Arg Arg Pro Ala Tyr Arg Asp Asn Gln Trp Asn 
                1365                1370                1375    
Pro Arg Gln Ser Glu Val Pro Lys Pro Glu Asp Gly Glu Pro Pro Arg 
            1380                1385                1390        
Arg His Glu Gln Phe Ile Pro Ile Ala Ala Asp Lys Arg Pro Pro Lys 
        1395                1400                1405            
Phe Glu Arg Lys Phe Asp Pro Ala Arg Glu Arg Pro Arg Arg Gln Arg 
    1410                1415                1420                
Pro Thr Arg Pro Pro Arg Gln Asp Lys Pro Pro Arg Phe Arg Arg Leu 
1425                1430                1435                1440
Arg Glu Arg Glu Ala Ala Ser Lys Ser Asn Glu Val Val Ala Val Pro 
                1445                1450                1455    
Thr Asn Gly Thr Val Asn Asn Val Ala Gln Glu Pro Val Asn Thr Leu 
            1460                1465                1470        
Gly Asp Ile Ser Gly Asn Lys Thr Pro Asp Leu Ser Asn Gln Asn Ser 
        1475                1480                1485            
Ser Asp Gln Ala Asn Glu Glu Trp Glu Thr Ala Ser Glu Ser Ser Asp 
    1490                1495                1500                
Phe Asn Glu Arg Arg Glu Arg Asp Glu Lys Lys Asn Ala Asp Leu Asn 
1505                1510                1515                1520
Ala Gln Thr Val Val Lys Val Gly Glu Asn Val Leu Pro Pro Lys Arg 
                1525                1530                1535    
Glu Ile Ala Lys Arg Ser Phe Ser Ser Gln Arg Pro Val Asp Arg Gln 
            1540                1545                1550        
Asn Arg Arg Gly Asn Asn Gly Pro Pro Lys Ser Gly Arg Asn Phe Ser 
        1555                1560                1565            
Gly Pro Arg Asn Glu Arg Arg Ser Gly Pro Pro Ser Lys Ser Gly Lys 
    1570                1575                1580                
Arg Gly Pro Phe Asp Asp Gln Pro Ala Gly Thr Thr Gly Val Asp Leu 
1585                1590                1595                1600
Ile Asn Gly Ser Ser Ala His His Gln Glu Gly Val Pro Asn Gly Thr 
                1605                1610                1615    
Gly Gln Lys Asn Ser Lys Asp Ser Thr Gly Lys Lys Arg Glu Asp Pro 
            1620                1625                1630        
Lys Pro Gly Pro Lys Lys Pro Lys Glu Lys Val Asp Ala Leu Ser Gln 
        1635                1640                1645            
Phe Asp Leu Asn Asn Tyr Ala Ser Val Val Ile Ile Asp Asp His Pro 
    1650                1655                1660                
Glu Val Thr Val Ile Glu Asp Pro Gln Ser Asn Leu Asn Asp Asp Gly 
1665                1670                1675                1680
Phe Thr Glu Val Val Ser Lys Lys Gln Gln Lys Arg Leu Gln Asp Glu 
                1685                1690                1695    
Glu Arg Arg Lys Lys Glu Glu Gln Val Ile Gln Val Trp Asn Lys Lys 
            1700                1705                1710        
Asn Ala Asn Glu Lys Gly Arg Ser Gln Thr Ser Lys Leu Pro Pro Arg 
        1715                1720                1725            
Phe Ala Lys Lys Gln Ala Thr Gly Ile Gln Gln Ala Gln Ser Ser Ala 
    1730                1735                1740                
Ser Val Pro Pro Leu Ala Ser Ala Pro Leu Pro Pro Ser Thr Ser Ala 
1745                1750                1755                1760
Ser Val Pro Ala Ser Thr Ser Ala Pro Leu Pro Ala Thr Leu Thr Pro 
                1765                1770                1775    
Val Pro Ala Ser Thr Ser Ala Pro Val Pro Ala Ser Thr Leu Ala Pro 
            1780                1785                1790        
Val Leu Ala Ser Thr Ser Ala Pro Val Pro Ala Ser Pro Leu Ala Pro 
        1795                1800                1805            
Val Ser Ala Ser Ala Ser Val Ser Ala Ser Val Pro Ala Ser Thr Ser 
    1810                1815                1820                
Ala Ala Ala Ile Thr Ser Ser Ser Ala Pro Ala Ser Ala Pro Ala Pro 
1825                1830                1835                1840
Thr Pro Ile Leu Ala Ser Val Ser Thr Pro Ala Ser Val Thr Ile Leu 
                1845                1850                1855    
Ala Ser Ala Ser Ile Pro Ile Leu Ala Ser Ala Leu Ala Ser Thr Ser 
            1860                1865                1870        
Ala Pro Thr Pro Ala Pro Ala Ala Ser Ser Pro Ala Ala Pro Val Ile 
        1875                1880                1885            
Thr Ala Pro Thr Ile Pro Ala Ser Ala Pro Thr Ala Ser Val Pro Leu 
    1890                1895                1900                
Ala Pro Ala Ser Ala Ser Ala Pro Ala Pro Ala Pro Thr Pro Val Ser 
1905                1910                1915                1920
Ala Pro Asn Pro Ala Pro Pro Ala Pro Ala Gln Thr Gln Ala Gln Thr 
                1925                1930                1935    
His Lys Pro Val Gln Asn Pro Leu Gln Thr Thr Ser Gln Ser Ser Lys 
            1940                1945                1950        
Gln Pro Pro Pro Ser Ile Arg Leu Pro Ser Ala Gln Thr Pro Asn Gly 
        1955                1960                1965            
Thr Asp Tyr Val Ala Ser Gly Lys Ser Ile Gln Thr Pro Gln Ser His 
    1970                1975                1980                
Gly Thr Leu Thr Ala Glu Leu Trp Asp Asn Lys Val Ala Pro Pro Ala 
1985                1990                1995                2000
Val Leu Asn Asp Ile Ser Lys Lys Leu Gly Pro Ile Ser Pro Pro Gln 
                2005                2010                2015    
Pro Pro Ser Val Ser Ala Trp Asn Lys Pro Leu Thr Ser Phe Gly Ser 
            2020                2025                2030        
Ala Pro Ser Ser Glu Gly Ala Lys Asn Gly Gln Glu Ser Gly Leu Glu 
        2035                2040                2045            
Ile Gly Thr Asp Thr Ile Gln Phe Gly Ala Pro Ala Ser Asn Gly Asn 
    2050                2055                2060                
Glu Asn Glu Val Val Pro Val Leu Ser Glu Lys Ser Ala Asp Lys Ile 
2065                2070                2075                2080
Pro Glu Pro Lys Glu Gln Arg Gln Lys Gln Pro Arg Ala Gly Pro Ile 
                2085                2090                2095    
Lys Ala Gln Lys Leu Pro Asp Leu Ser Pro Val Glu Asn Lys Glu His 
            2100                2105                2110        
Lys Pro Gly Pro Ile Gly Lys Glu Arg Ser Leu Lys Asn Arg Lys Val 
        2115                2120                2125            
Lys Asp Ala Gln Gln Val Glu Pro Glu Gly Gln Glu Lys Pro Ser Pro 
    2130                2135                2140                
Ala Thr Val Arg Ser Thr Asp Pro Val Thr Thr Lys Glu Thr Lys Ala 
2145                2150                2155                2160
Val Ser Glu Met Ser Thr Glu Ile Gly Thr Met Ile Ser Val Ser Ser 
                2165                2170                2175    
Ala Glu Tyr Gly Thr Asn Ala Lys Glu Ser Val Thr Asp Tyr Thr Thr 
            2180                2185                2190        
Pro Ser Ser Ser Leu Pro Asn Thr Val Ala Thr Asn Asn Thr Lys Met 
        2195                2200                2205            
Glu Asp Thr Leu Val Asn Asn Val Pro Leu Pro Asn Thr Leu Pro Leu 
    2210                2215                2220                
Pro Lys Arg Glu Thr Ile Gln Gln Ser Ser Ser Leu Thr Ser Val Pro 
2225                2230                2235                2240
Pro Thr Thr Phe Ser Leu Thr Phe Lys Met Glu Ser Ala Arg Lys Ala 
                2245                2250                2255    
Trp Glu Asn Ser Pro Asn Val Arg Glu Lys Gly Ser Pro Val Thr Ser 
            2260                2265                2270        
Thr Ala Pro Pro Ile Ala Thr Gly Val Ser Ser Ser Ala Ser Gly Pro 
        2275                2280                2285            
Ser Thr Ala Asn Tyr Asn Ser Phe Ser Ser Ala Ser Met Pro Gln Ile 
    2290                2295                2300                
Pro Val Ala Ser Val Thr Pro Thr Ala Ser Leu Ser Gly Ala Gly Thr 
2305                2310                2315                2320
Tyr Thr Thr Ser Ser Leu Ser Thr Lys Ser Thr Thr Thr Ser Asp Pro 
                2325                2330                2335    
Pro Asn Ile Cys Lys Val Lys Pro Gln Gln Leu Gln Thr Ser Ser Leu 
            2340                2345                2350        
Pro Ser Ala Ser His Phe Ser Gln Leu Ser Cys Met Pro Ser Leu Ile 
        2355                2360                2365            
Ala Gln Gln Gln Gln Asn Pro Gln Val Tyr Val Ser Gln Ser Ala Ala 
    2370                2375                2380                
Ala Gln Ile Pro Ala Phe Tyr Met Asp Thr Ser His Leu Phe Asn Thr 
2385                2390                2395                2400
Gln His Ala Arg Leu Ala Pro Pro Ser Leu Ala Gln Gln Gln Gly Phe 
                2405                2410                2415    
Gln Pro Gly Leu Ser Gln Pro Thr Ser Val Gln Gln Ile Pro Ile Pro 
            2420                2425                2430        
Ile Tyr Ala Pro Leu Gln Gly Gln His Gln Ala Gln Leu Ser Leu Gly 
        2435                2440                2445            
Ala Gly Pro Ala Val Ser Gln Ala Gln Glu Leu Phe Ser Ser Ser Leu 
    2450                2455                2460                
Gln Pro Tyr Arg Ser Gln Pro Ala Phe Met Gln Ser Ser Leu Ser Gln 
2465                2470                2475                2480
Pro Ser Val Val Leu Ser Gly Thr Ala Ile His Asn Phe Pro Thr Val 
                2485                2490                2495    
Gln His Gln Glu Leu Ala Lys Ala Gln Ser Gly Leu Ala Phe Gln Gln 
            2500                2505                2510        
Thr Ser Asn Thr Gln Pro Ile Pro Ile Leu Tyr Glu His Gln Leu Gly 
        2515                2520                2525            
Gln Ala Ser Gly Leu Gly Gly Ser Gln Leu Ile Asp Thr His Leu Leu 
    2530                2535                2540                
Gln Ala Arg Ala Asn Leu Thr Gln Ala Ser Asn Leu Tyr Ser Gly Gln 
2545                2550                2555                2560
Val Gln Gln Pro Gly Gln Thr Asn Phe Tyr Asn Thr Ala Gln Ser Pro 
                2565                2570                2575    
Ser Ala Leu Gln Gln Val Thr Val Pro Leu Pro Ala Ser Gln Leu Ser 
            2580                2585                2590        
Leu Pro Asn Phe Gly Ser Thr Gly Gln Pro Leu Ile Ala Leu Pro Gln 
        2595                2600                2605            
Thr Leu Gln Pro Pro Leu Gln His Thr Thr Pro Gln Ala Gln Ala Gln 
    2610                2615                2620                
Ser Leu Ser Arg Pro Ala Gln Val Ser Gln Pro Phe Arg Gly Leu Ile 
2625                2630                2635                2640
Pro Ala Gly Thr Gln His Ser Met Ile Ala Thr Thr Gly Lys Met Ser 
                2645                2650                2655    
Glu Met Glu Leu Lys Ala Phe Gly Ser Gly Ile Asp Ile Lys Pro Gly 
            2660                2665                2670        
Thr Pro Pro Ile Ala Gly Arg Ser Thr Thr Pro Thr Ser Ser Pro Phe 
        2675                2680                2685            
Arg Ala Thr Ser Thr Ser Pro Asn Ser Gln Ser Ser Lys Met Asn Ser 
    2690                2695                2700                
Ile Val Tyr Gln Lys Gln Phe Gln Ser Ala Pro Ala Thr Val Arg Met 
2705                2710                2715                2720
Thr Gln Pro Phe Pro Thr Gln Phe Ala Pro Gln Ile Leu Ser Gln Pro 
                2725                2730                2735    
Asn Leu Val Pro Pro Leu Val Arg Ala Pro His Thr Asn Thr Phe Pro 
            2740                2745                2750        
Ala Pro Val Gln Arg Pro Pro Met Ala Leu Ala Ser Gln Met Pro Pro 
        2755                2760                2765            
Pro Leu Thr Thr Gly Leu Met Ser His Ala Arg Leu Pro His Val Ala 
    2770                2775                2780                
Arg Gly Pro Cys Gly Ser Leu Ser Gly Val Arg Gly Asn Gln Ala Gln 
2785                2790                2795                2800
Ala Ala Leu Lys Ala Glu Gln Asp Met Lys Ala Lys Gln Arg Ala Glu 
                2805                2810                2815    
Val Leu Gln Ser Thr Gln Arg Phe Phe Ser Glu Gln Gln Gln Ser Lys 
            2820                2825                2830        
Gln Ile Gly Gly Gly Lys Ala Gln Lys Val Asp Ser Asp Ser Ser Lys 
        2835                2840                2845            
Pro Pro Glu Thr Leu Thr Asp Pro Pro Gly Val Cys Gln Glu Lys Val 
    2850                2855                2860                
Glu Glu Lys Pro Pro Pro Ala Pro Ser Ile Ala Thr Lys Pro Val Arg 
2865                2870                2875                2880
Thr Gly Pro Ile Lys Pro Gln Ala Ile Lys Thr Glu Glu Thr Lys Ser 
                2885                2890                2895    



<210> 146
<211> 108
<212> PRT
<213> human

<400> 146
Asp Ile Gln Met Thr Gln Ser Pro Ser Pro Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Ser Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Arg Asn Ser 
            20                  25                  30          
Leu Ile Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              
Tyr Asp Ala Glu Asn Leu Glu Ile Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Ala Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             

<210> 147
<211> 175
<212> PRT
<213> human

<400> 147
Met Ser Tyr Asn Cys Cys Ser Gly Asn Phe Ser Ser Arg Ser Cys Gly 
1               5                   10                  15      
Asp Tyr Leu Arg Tyr Pro Ala Ser Ser Arg Gly Phe Ser Tyr Pro Ser 
            20                  25                  30          
Asn Leu Val Tyr Ser Thr Asp Leu Cys Ser Pro Ser Thr Cys Gln Leu 
        35                  40                  45              
Gly Ser Ser Leu Tyr Arg Gly Cys Gln Glu Ile Cys Trp Glu Pro Thr 
    50                  55                  60                  
Ser Cys Gln Thr Ser Tyr Val Glu Ser Ser Pro Cys Gln Thr Ser Cys 
65                  70                  75                  80  
Tyr Arg Pro Arg Thr Ser Leu Leu Cys Ser Pro Cys Lys Thr Thr Tyr 
                85                  90                  95      
Ser Gly Ser Leu Gly Phe Gly Ser Ser Ser Cys Arg Ser Leu Gly Tyr 
            100                 105                 110         
Gly Ser Arg Ser Cys Tyr Ser Val Gly Cys Gly Ser Ser Gly Val Arg 
        115                 120                 125             
Ser Leu Gly Tyr Gly Ser Cys Gly Phe Pro Ser Leu Gly Tyr Gly Ser 
    130                 135                 140                 
Gly Phe Cys Arg Pro Thr Tyr Leu Ala Ser Arg Ser Cys Gln Ser Pro 
145                 150                 155                 160 
Cys Tyr Arg Pro Ala Tyr Gly Ser Thr Phe Cys Arg Ser Thr Cys 
                165                 170                 175 

<210> 148
<211> 101
<212> PRT
<213> human

<400> 148
Met Asn Lys Leu Gly His Asn Glu Leu Lys Glu Cys Leu Lys Thr Ala 
1               5                   10                  15      
Thr Asp Ser Leu Gln Thr Val Gln Pro Ser Ile Ser Gln Thr Cys Thr 
            20                  25                  30          
Ser Tyr Gly Pro Ala Leu Gly Ala Pro Leu Pro Gly Arg Asn Glu Val 
        35                  40                  45              
Ala Leu Leu Thr Ser Leu Pro Pro Asn Tyr Glu Ile Ser Glu Gly Lys 
    50                  55                  60                  
Pro Arg Ala Ile Ser Ala Tyr Val Arg Ala Gly Lys Gly Asn Val Thr 
65                  70                  75                  80  
Arg Arg Arg Lys Lys Thr His Leu Gly Asn Asp Asp Gly Lys Lys Glu 
                85                  90                  95      
Ala Gln Glu Lys Met 
            100     

